Detailed information for compound 1402560

Basic information

Technical information
  • TDR Targets ID: 1402560
  • Name: (4S,6S)-4-(1-benzothiophen-3-yl)-6-(4-hydroxy butoxy)-N-(phenylmethyl)-5,6-dihydro-4H-pyran -2-carboxamide
  • MW: 437.551 | Formula: C25H27NO4S
  • H donors: 2 H acceptors: 2 LogP: 4.66 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCCCO[C@H]1OC(=C[C@H](C1)c1csc2c1cccc2)C(=O)NCc1ccccc1
  • InChi: 1S/C25H27NO4S/c27-12-6-7-13-29-24-15-19(21-17-31-23-11-5-4-10-20(21)23)14-22(30-24)25(28)26-16-18-8-2-1-3-9-18/h1-5,8-11,14,17,19,24,27H,6-7,12-13,15-16H2,(H,26,28)/t19-,24+/m1/s1
  • InChiKey: VTBDOHYDJABJRC-DVECYGJZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4S,6S)-4-(benzothiophen-3-yl)-6-(4-hydroxybutoxy)-N-(phenylmethyl)-5,6-dihydro-4H-pyran-2-carboxamide
  • (4S,6S)-4-(3-benzothiophenyl)-6-(4-hydroxybutoxy)-N-(phenylmethyl)-5,6-dihydro-4H-pyran-2-carboxamide
  • (4S,6S)-4-(benzothiophen-3-yl)-N-(benzyl)-6-(4-hydroxybutoxy)-5,6-dihydro-4H-pyran-2-carboxamide
  • SMR000442078
  • MLS000834568

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0053 0.0172 0.0449
Loa Loa (eye worm) tubulin alpha 2 0.004 0.0116 0.0304
Plasmodium vivax tubulin epsilon chain, putative 0.0028 0.0064 0.0177
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0119 0.0971
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0042 0.0085
Schistosoma mansoni alpha tubulin 0.0053 0.017 0.0174
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0153 0.0157
Trypanosoma cruzi UDP-galactopyranose mutase 0.0062 0.0212 0.0789
Leishmania major hypothetical protein, conserved 0.0034 0.0088 0.0327
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0696 0.1597
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0053 0.0172 0.058
Echinococcus multilocularis tubulin epsilon chain 0.0028 0.0064 0.0065
Trichomonas vaginalis tubulin alpha chain, putative 0.0028 0.0064 0.0147
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0045 0.0137 0.0189
Loa Loa (eye worm) hypothetical protein 0.0053 0.017 0.0444
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0083 0.0248
Echinococcus granulosus lysine specific histone demethylase 1A 0.0062 0.0212 0.0217
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0083 0.0076
Brugia malayi Tubulin alpha-2 chain 0.0053 0.017 0.0234
Echinococcus granulosus tubulin gamma 1 chain 0.0028 0.0064 0.0065
Brugia malayi hypothetical protein 0.0062 0.0212 0.0293
Onchocerca volvulus 0.0031 0.0076 0.0076
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0248 0.0648
Schistosoma mansoni hypothetical protein 0.004 0.0115 0.0118
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0119 0.0971
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0042 0.0068
Echinococcus multilocularis neural cadherin 0.0028 0.0063 0.0064
Echinococcus multilocularis cpg binding protein 0.0031 0.0074 0.0076
Giardia lamblia Alpha-tubulin 0.0053 0.017 0.0407
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0208 0.0775
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0073 0.0272
Loa Loa (eye worm) hypothetical protein 0.0027 0.0058 0.0153
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0034 0.0088 0.0095
Loa Loa (eye worm) alpha-tubulin 0.0053 0.017 0.0444
Loa Loa (eye worm) hypothetical protein 0.0023 0.0042 0.011
Onchocerca volvulus Neurogenic locus notch homolog 0.0028 0.0063 0.0063
Leishmania major gamma-tubulin 0.0028 0.0064 0.0238
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0466 0.3795
Leishmania major beta tubulin 0.0028 0.0064 0.0238
Onchocerca volvulus Arrow homolog 0.0074 0.0261 0.0261
Echinococcus granulosus delta-like protein 1 0.0028 0.0063 0.0064
Brugia malayi beta-tubulin, identical 0.0028 0.0064 0.0088
Brugia malayi hypothetical protein 0.0041 0.0118 0.0162
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0034 0.0088 0.0095
Schistosoma mansoni amine oxidase 0.0062 0.0212 0.0217
Schistosoma mansoni notch 0.0028 0.0063 0.0064
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0067 0.0233 0.0239
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0083 0.019
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0369 0.0378
Toxoplasma gondii kringle domain-containing protein 0.0097 0.0363 0.1143
Trichomonas vaginalis tubulin gamma chain, putative 0.0028 0.0064 0.0147
Schistosoma mansoni cpg binding protein 0.0031 0.0074 0.0076
Schistosoma mansoni tubulin subunit gamma 0.0028 0.0064 0.0065
Brugia malayi jmjC domain containing protein 0.0034 0.0088 0.0121
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0073 0.0272
Schistosoma mansoni jumonji domain containing protein 0.0127 0.0493 0.0505
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0062 0.0212 0.0732
Plasmodium vivax telomerase reverse transcriptase, putative 0.0631 0.2688 1
Echinococcus granulosus phd:f box containing protein 0.0034 0.0088 0.009
Echinococcus multilocularis slit 2 protein 0.0028 0.0063 0.0064
Leishmania major beta tubulin 0.0028 0.0064 0.0238
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0658 0.1509
Echinococcus multilocularis tubulin alpha 1C chain 0.0053 0.017 0.0174
Trypanosoma brucei beta tubulin 0.0028 0.0064 0.0238
Echinococcus multilocularis Mastin 0.0027 0.0058 0.006
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0027 0.0058 0.006
Echinococcus multilocularis muscleblind protein 1 0.0489 0.2067 0.2119
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.1229 0.2819
Loa Loa (eye worm) tyrosinase 1 0.0184 0.0739 0.1934
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0208 0.0775
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0083 0.019
Schistosoma mansoni notch 0.0028 0.0063 0.0064
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0053 0.0172 0.058
Echinococcus granulosus Mastin 0.0027 0.0058 0.006
Schistosoma mansoni tubulin subunit beta 0.0028 0.0064 0.0065
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Echinococcus multilocularis enteropeptidase 0.0027 0.0058 0.006
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0153 0.0211
Echinococcus multilocularis glycoprotein Antigen 5 0.0027 0.0058 0.006
Schistosoma mansoni microtubule-associated protein tau 0.2255 0.9755 1
Echinococcus multilocularis beta tubulin 0.0028 0.0064 0.0065
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0034 0.0088 0.0327
Leishmania major epsilon tubulin, putative 0.0028 0.0064 0.0238
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0074 0.0261 0.036
Echinococcus granulosus lysine specific histone demethylase 1A 0.0062 0.0212 0.0217
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.05 0.0513
Brugia malayi Kringle domain containing protein 0.0097 0.0363 0.05
Loa Loa (eye worm) BEN-1 protein 0.0028 0.0064 0.0167
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0153 0.0157
Loa Loa (eye worm) tubulin alpha chain 0.0053 0.017 0.0444
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0028 0.0063 0.0064
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0028 0.0063 0.0063
Loa Loa (eye worm) tubulin beta chain 0.0028 0.0064 0.0167
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0042 0.0157
Schistosoma mansoni hypothetical protein 0.0028 0.0063 0.0064
Echinococcus granulosus tubulin alpha 3 chain 0.0053 0.017 0.0174
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0466 0.107
Brugia malayi hypothetical protein 0.003 0.0073 0.0101
Schistosoma mansoni tubulin subunit epsilon 0.0028 0.0064 0.0065
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0073 0.0212
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0208 0.0478
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.002 0.0045
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0153 0.0157
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0109 0.0112
Schistosoma mansoni hypothetical protein 0.004 0.0115 0.0118
Echinococcus multilocularis Tubulin beta 2C chain 0.0028 0.0064 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0658 0.1509
Onchocerca volvulus 0.0028 0.0063 0.0063
Brugia malayi MH2 domain containing protein 0.0144 0.0568 0.0783
Echinococcus multilocularis neurogenic locus notch protein 4 0.0028 0.0063 0.0064
Brugia malayi jmjC domain containing protein 0.0128 0.05 0.0689
Echinococcus granulosus protein jagged 1 0.0028 0.0063 0.0064
Mycobacterium ulcerans 6-phosphofructokinase 0.0121 0.0466 0.119
Brugia malayi hypothetical protein 0.0041 0.0118 0.0162
Schistosoma mansoni notch 0.0028 0.0063 0.0064
Loa Loa (eye worm) ShTK domain-containing protein 0.0184 0.0739 0.1934
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0062 0.0212 0.0732
Loa Loa (eye worm) hypothetical protein 0.0062 0.0212 0.0555
Brugia malayi jmjC domain containing protein 0.0034 0.0088 0.0121
Loa Loa (eye worm) tubulin alpha 2 0.004 0.0116 0.0304
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.1229 0.2819
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0037 0.01 0.0229
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0544 0.0557
Loa Loa (eye worm) hypothetical protein 0.0074 0.0261 0.0682
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0045 0.0137 0.0189
Giardia lamblia Beta tubulin 0.0028 0.0064 0.0004
Leishmania major beta tubulin 0.0028 0.0064 0.0238
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.0526 0.0539
Onchocerca volvulus 0.0027 0.0058 0.0058
Echinococcus multilocularis protein patched 0.0042 0.0122 0.0125
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0208 0.0555
Echinococcus multilocularis beta tubulin 0.0028 0.0064 0.0065
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0045 0.0137 0.0189
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0053 0.0172 0.0414
Brugia malayi Protein kinase domain containing protein 0.0097 0.0363 0.05
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.023 0.0235
Loa Loa (eye worm) alpha-tubulin isotype 2 0.004 0.0116 0.0304
Entamoeba histolytica tubulin family protein 0.0028 0.0064 0.052
Leishmania major alpha tubulin 0.0053 0.017 0.0631
Echinococcus multilocularis tubulin subunit TubB 0.0053 0.017 0.0174
Entamoeba histolytica hypothetical protein 0.0035 0.0095 0.0771
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0042 0.0068
Loa Loa (eye worm) phosphofructokinase 0.0121 0.0466 0.122
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0123 0.0477 0.0489
Loa Loa (eye worm) trypsin family protein 0.0027 0.0058 0.0153
Loa Loa (eye worm) hypothetical protein 0.0034 0.0088 0.023
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0121 0.0466 0.8037
Loa Loa (eye worm) jmjC domain-containing protein 0.0128 0.05 0.1307
Leishmania major UDP-galactopyranose mutase 0.0062 0.0212 0.0789
Echinococcus multilocularis Tubulin beta 2C chain 0.0028 0.0064 0.0065
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0027 0.0058 0.006
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0083 0.019
Echinococcus multilocularis tar DNA binding protein 0.0262 0.108 0.1107
Leishmania major alpha tubulin 0.0053 0.017 0.0631
Giardia lamblia Alpha-tubulin 0.0053 0.017 0.0407
Loa Loa (eye worm) hypothetical protein 0.0034 0.0088 0.023
Schistosoma mansoni cpg binding protein 0.0031 0.0074 0.0076
Echinococcus multilocularis tubulin alpha chain 0.0053 0.017 0.0174
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0201 0.0526
Brugia malayi Trypsin family protein 0.0027 0.0058 0.0081
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0134 0.0526 0.0725
Echinococcus multilocularis tubulin alpha 1C chain 0.0053 0.017 0.0174
Echinococcus multilocularis jumonji domain containing 1A 0.0034 0.0088 0.009
Echinococcus multilocularis tubulin alpha chain 0.0053 0.017 0.0174
Loa Loa (eye worm) tubulin beta-2A chain 0.0028 0.0064 0.0167
Toxoplasma gondii calcium binding egf domain-containing protein 0.0074 0.0261 0.0754
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Echinococcus multilocularis expressed protein 0.0053 0.0172 0.0176
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0027 0.0058 0.006
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0208 0.0775
Echinococcus multilocularis muscleblind protein 0.0489 0.2067 0.2119
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.1229 0.2819
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0083 0.019
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Leishmania major beta tubulin 0.0028 0.0064 0.0238
Echinococcus multilocularis transmembrane protease serine 3 0.0027 0.0058 0.006
Loa Loa (eye worm) hypothetical protein 0.0154 0.0611 0.1598
Trichomonas vaginalis tubulin beta chain, putative 0.0016 0.001 0.0024
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0153 0.04
Loa Loa (eye worm) hypothetical protein 0.0184 0.0739 0.1934
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0886 0.3796 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0232 0.0862
Onchocerca volvulus Huntingtin homolog 0.014 0.055 0.055
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0208 0.0478
Loa Loa (eye worm) hypothetical protein 0.0055 0.018 0.047
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0042 0.0058
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0083 0.0248
Echinococcus granulosus tubulin alpha chain 0.0053 0.017 0.0174
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.002 0.0045
Schistosoma mansoni jumonji/arid domain-containing protein 0.0128 0.05 0.0512
Trypanosoma cruzi epsilon tubulin, putative 0.0028 0.0064 0.0238
Giardia lamblia Beta tubulin 0.0028 0.0064 0.0004
Loa Loa (eye worm) hypothetical protein 0.0062 0.0212 0.0555
Echinococcus granulosus neurogenic locus notch protein 4 0.0028 0.0063 0.0064
Echinococcus granulosus tubulin subunit TubB 0.0053 0.017 0.0174
Echinococcus granulosus tubulin alpha 3 chain 0.0053 0.017 0.0174
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0043
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0035 0.0095 0.0097
Leishmania major beta tubulin 0.0028 0.0064 0.0238
Brugia malayi EGF-like domain containing protein 0.0028 0.0063 0.0087
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0004 0.001
Leishmania major beta tubulin 0.0028 0.0064 0.0238
Schistosoma mansoni hypothetical protein 0.0049 0.0153 0.0157
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0316 0.1317 0.4867
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Trypanosoma brucei glucosidase, putative 0.0037 0.01 0.0372
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.01 0.0229
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0073 0.0272
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0045 0.0137 0.0282
Trichomonas vaginalis tubulin beta chain, putative 0.0053 0.017 0.0389
Echinococcus multilocularis sentrin specific protease 8 0.0067 0.0233 0.0239
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0053 0.0172 0.0237
Echinococcus granulosus fibropellin Ia 0.0028 0.0063 0.0064
Echinococcus multilocularis tissue type plasminogen activator 0.0097 0.0363 0.0372
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0063 0.0143
Onchocerca volvulus Putative cubilin 0.0028 0.0063 0.0063
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0064 0.022 0.0598
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0208 0.0775
Echinococcus granulosus protein jagged 2 0.0028 0.0063 0.0064
Plasmodium vivax tubulin beta chain, putative 0.0028 0.0064 0.0177
Echinococcus granulosus sentrin specific protease 8 0.0067 0.0233 0.0239
Schistosoma mansoni patched 1 0.0042 0.0122 0.0125
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0232 0.0237
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0209 0.0778
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.1229 0.2819
Schistosoma mansoni hypothetical protein 0.0028 0.0063 0.0064
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0028 0.0064 0.0065
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0208 0.0478
Brugia malayi Tubulin alpha chain 0.0053 0.017 0.0234
Brugia malayi jmjC domain containing protein 0.0034 0.0088 0.0121
Echinococcus granulosus Tubulin beta 2C chain 0.0028 0.0064 0.0065
Schistosoma mansoni tubulin subunit beta 0.0028 0.0064 0.0065
Schistosoma mansoni tubulin subunit beta 0.0028 0.0064 0.0065
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0659 0.0675
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0027 0.0058 0.006
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0058 0.006
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Mycobacterium ulcerans hypothetical protein 0.0023 0.0042 0.0068
Leishmania major beta tubulin 0.0028 0.0064 0.0238
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Echinococcus multilocularis tubulin gamma 1 chain 0.0028 0.0064 0.0065
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0027 0.0058 0.006
Schistosoma mansoni hypothetical protein 0.0105 0.0399 0.0409
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0232 0.0862
Treponema pallidum fructose-bisphosphate aldolase 0.0296 0.1229 1
Brugia malayi EGF-like domain containing protein 0.0028 0.0063 0.0087
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0696 0.1597
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.1229 0.2819
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.1034 0.237
Echinococcus granulosus beta tubulin 0.0028 0.0064 0.0065
Schistosoma mansoni tar DNA-binding protein 0.0262 0.108 0.1107
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0658 0.1509
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0058 0.006
Schistosoma mansoni alpha-glucosidase 0.0142 0.0559 0.0573
Leishmania major alpha tubulin 0.0053 0.017 0.0631
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0083 0.0248
Loa Loa (eye worm) hypothetical protein 0.0042 0.0122 0.0318
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0043
Echinococcus granulosus tubulin alpha 1C chain 0.0053 0.017 0.0174
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0208 0.0775
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.01 0.0229
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.1034 0.237
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Schistosoma mansoni phosphatidylserine receptor 0.0034 0.0088 0.009
Echinococcus multilocularis protoporphyrinogen oxidase 0.0062 0.0212 0.0217
Echinococcus granulosus Tubulin alpha 1 chain 0.0053 0.017 0.0174
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0088 0.023
Echinococcus multilocularis fibrillin 1 0.0074 0.0261 0.0267
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0208 0.0775
Schistosoma mansoni alpha tubulin 0.0053 0.017 0.0174
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0074 0.0261 0.0267
Onchocerca volvulus 0.0028 0.0063 0.0063
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0544 0.0557
Leishmania major beta tubulin 0.0028 0.0064 0.0238
Onchocerca volvulus Huntingtin homolog 0.014 0.055 0.055
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0067 0.0233 0.0535
Echinococcus multilocularis tubulin alpha 3 chain 0.0053 0.017 0.0174
Echinococcus multilocularis neurogenic locus protein delta 0.0028 0.0063 0.0064
Schistosoma mansoni hypothetical protein 0.0049 0.0153 0.0157
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.0658 0.0658
Loa Loa (eye worm) tubulin alpha-3 chain 0.0037 0.01 0.0261
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0027 0.0058 0.006
Trichomonas vaginalis tubulin alpha chain, putative 0.0016 0.001 0.0024
Brugia malayi CXXC zinc finger family protein 0.0029 0.0067 0.0093
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0119 0.0971
Leishmania major telomerase reverse transcriptase, putative 0.0631 0.2688 1
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0316 0.1317 0.3441
Schistosoma mansoni tyrosinase precursor 0.0184 0.0739 0.0758
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0127 0.0493 0.0505
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0043
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0209 0.0214
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0083 0.0076
Brugia malayi Fibulin-1 precursor 0.0074 0.0261 0.036
Loa Loa (eye worm) hypothetical protein 0.0074 0.0261 0.0682
Plasmodium falciparum tubulin beta chain 0.0028 0.0064 0.0177
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0232 0.0237
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0042 0.0058
Plasmodium vivax SET domain protein, putative 0.0129 0.05 0.181
Trypanosoma brucei tubulin gamma chain 0.0028 0.0064 0.0238
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0113 0.0113
Leishmania major alpha tubulin 0.0053 0.017 0.0631
Brugia malayi EGF-like domain containing protein 0.0028 0.0063 0.0087
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.0526 0.0539
Trichomonas vaginalis Sentrin-specific protease, putative 0.0067 0.0233 0.0535
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.018 0.0184
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0027 0.0058 0.0081
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.01 0.0142
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0062 0.0212 0.0217
Echinococcus granulosus microtubule associated protein 2 0.2255 0.9755 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0073 0.0191
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0208 0.0214
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0074 0.0261 0.0682
Schistosoma mansoni cpg binding protein 0.0029 0.0067 0.0069
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.002 0.0045
Echinococcus multilocularis microtubule associated protein 2 0.2255 0.9755 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0042 0.0344
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.0466 0.0478
Plasmodium falciparum alpha tubulin 2 0.0053 0.017 0.0573
Onchocerca volvulus 0.0028 0.0063 0.0063
Echinococcus granulosus neurogenic locus notch protein 0.0028 0.0063 0.0064
Loa Loa (eye worm) hypothetical protein 0.0023 0.0042 0.011
Loa Loa (eye worm) beta-tubulin 0.0028 0.0064 0.0167
Echinococcus granulosus chromobox protein 1 0.0071 0.0248 0.0254
Plasmodium falciparum JmjC domain-containing protein, putative 0.0034 0.0088 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0113 0.0259
Onchocerca volvulus 0.0055 0.018 0.018
Echinococcus multilocularis tumor protein p63 0.0376 0.1575 0.1615
Onchocerca volvulus 0.0027 0.0058 0.0058
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0074 0.0261 0.0682
Schistosoma mansoni tubulin subunit beta 0.0028 0.0064 0.0065
Onchocerca volvulus 0.0027 0.0058 0.0058
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0631 0.2688 1
Trypanosoma brucei epsilon tubulin 0.0028 0.0064 0.0238
Leishmania major beta tubulin 0.0028 0.0064 0.0238
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0129 0.05 0.0513
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0083 0.019
Echinococcus granulosus Tubulin beta 2C chain 0.0028 0.0064 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.014 0.055 0.0564
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.01 0.0102
Onchocerca volvulus 0.0029 0.0067 0.0067
Echinococcus multilocularis notch 0.0028 0.0063 0.0064
Onchocerca volvulus 0.0027 0.0058 0.0058
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0053 0.017 0.0389
Echinococcus multilocularis expressed conserved protein 0.0091 0.0337 0.0345
Plasmodium vivax tubulin alpha chain, putative 0.0053 0.017 0.0573
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.01 0.0262
Brugia malayi MAP kinase sur-1 0.0062 0.0208 0.0287
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.0659 0.0675
Toxoplasma gondii histone lysine-specific demethylase 0.0062 0.0212 0.0569
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0042 0.0344
Loa Loa (eye worm) hypothetical protein 0.0027 0.0058 0.0153
Echinococcus granulosus chromobox protein 1 0.0071 0.0248 0.0254
Brugia malayi Trypsin-like protease protein 5 0.0027 0.0058 0.0081
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0121 0.0466 0.3348
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0658 0.1509
Entamoeba histolytica tubulin alpha chain, putative 0.0053 0.017 0.1381
Echinococcus granulosus jumonji domain containing 1A 0.0034 0.0088 0.009
Loa Loa (eye worm) hypothetical protein 0.0489 0.2067 0.5407
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0045 0.0137 0.045
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0006 0.0014
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0209 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0006 0.0014
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.0466 0.0478
Brugia malayi Trypsin family protein 0.0027 0.0058 0.0081
Brugia malayi EGF-like domain containing protein 0.0028 0.0063 0.0087
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.0466 0.122
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0232 0.0319
Echinococcus granulosus transmembrane protease serine 3 0.0027 0.0058 0.006
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0119 0.0971
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0042 0.0058
Echinococcus multilocularis chromobox protein 1 0.0071 0.0248 0.0254
Echinococcus granulosus tubulin alpha chain 0.0053 0.017 0.0174
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0083 0.0673
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.01 0.0814
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0062 0.0212 0.0732
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0316 0.1317 0.3441
Brugia malayi Cadherin domain containing protein 0.0028 0.0063 0.0087
Brugia malayi chromobox protein homolog 3 0.004 0.0113 0.0156
Echinococcus granulosus lysine specific demethylase 6a 0.0034 0.0088 0.009
Schistosoma mansoni jumonji/arid domain-containing protein 0.0128 0.05 0.0512
Mycobacterium tuberculosis Possible oxidoreductase 0.0062 0.0212 0.0569
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0067 0.0233 0.1899
Schistosoma mansoni hypothetical protein 0.004 0.0115 0.0118
Echinococcus multilocularis neurogenic locus notch protein 0.0028 0.0063 0.0064
Echinococcus multilocularis Tubulin beta 2C chain 0.0028 0.0064 0.0065
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.0611 0.0843
Brugia malayi 6-phosphofructokinase 0.0121 0.0466 0.0643
Echinococcus multilocularis protein jagged 2 0.0028 0.0063 0.0064
Echinococcus granulosus laminin 0.0074 0.0261 0.0267
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.0399 0.055
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0466 0.107
Loa Loa (eye worm) hypothetical protein 0.0062 0.0212 0.0555
Echinococcus granulosus alpha tubulin 0.0053 0.017 0.0174
Brugia malayi EGF-like domain containing protein 0.0028 0.0063 0.0087
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0248 0.0568
Leishmania major beta tubulin 0.0028 0.0064 0.0238
Trichomonas vaginalis tubulin alpha chain, putative 0.0016 0.001 0.0024
Brugia malayi jmjC domain containing protein 0.0127 0.0493 0.0679
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0062 0.0212 0.0217
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0062 0.0212 0.3219
Trichomonas vaginalis tubulin gamma chain, putative 0.0028 0.0064 0.0147
Plasmodium falciparum tubulin gamma chain 0.0028 0.0064 0.0177
Trichomonas vaginalis tubulin alpha chain, putative 0.0016 0.001 0.0024
Echinococcus granulosus cpg binding protein 0.0031 0.0074 0.0076
Brugia malayi Pre-SET motif family protein 0.0892 0.3824 0.5273
Brugia malayi Tubulin alpha-2 chain 0.0053 0.017 0.0234
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0088 0.0327
Toxoplasma gondii beta-1 tubulin, putative 0.0028 0.0064 0.0004
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.4203 0.4308
Toxoplasma gondii calcium binding egf domain-containing protein 0.0074 0.0261 0.0754
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.0526 0.0539
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Brugia malayi Pre-SET motif family protein 0.0129 0.05 0.0689
Schistosoma mansoni tar DNA-binding protein 0.0262 0.108 0.1107
Echinococcus granulosus tubulin alpha chain 0.0053 0.017 0.0174
Echinococcus multilocularis neurogenic locus notch protein 0.0028 0.0063 0.0064
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0027 0.0058 0.006
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0042 0.0157
Echinococcus granulosus tubulin epsilon chain 0.0028 0.0064 0.0065
Loa Loa (eye worm) hypothetical protein 0.0062 0.0212 0.0555
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.057 0.1588
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0027 0.0058 0.006
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0208 0.0478
Schistosoma mansoni hypothetical protein 0.0028 0.0063 0.0064
Trichomonas vaginalis tubulin beta chain, putative 0.0053 0.017 0.0389
Trichomonas vaginalis set domain proteins, putative 0.1015 0.436 1
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0208 0.0214
Trichomonas vaginalis tubulin beta chain, putative 0.0053 0.017 0.0389
Echinococcus multilocularis geminin 0.0205 0.0831 0.0852
Echinococcus granulosus tubulin alpha 0.0028 0.0064 0.0065
Loa Loa (eye worm) tubulin beta-4 chain 0.0028 0.0064 0.0167
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0208 0.0214
Echinococcus multilocularis protein jagged 1 0.0028 0.0063 0.0064
Trypanosoma cruzi tubulin gamma chain 0.0028 0.0064 0.0238
Echinococcus multilocularis phd:f box containing protein 0.0034 0.0088 0.009
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0208 0.0775
Schistosoma mansoni hypothetical protein 0.0049 0.0153 0.0157
Loa Loa (eye worm) hypothetical protein 0.0129 0.05 0.1308
Echinococcus granulosus tubulin beta 1 chain 0.0028 0.0064 0.0065
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0316 0.1317 1
Schistosoma mansoni notch 0.0028 0.0063 0.0064
Echinococcus granulosus JmjC domain containing protein 4 0.0034 0.0088 0.009
Leishmania major alpha tubulin 0.0053 0.017 0.0631
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0042 0.0085
Schistosoma mansoni hypothetical protein 0.0028 0.0063 0.0064
Leishmania major beta tubulin 0.0028 0.0064 0.0238
Echinococcus multilocularis Tubulin alpha 1 chain 0.0053 0.017 0.0174
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0045 0.0137 0.045
Loa Loa (eye worm) glutaminase 0.0277 0.1146 0.2996
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0053 0.0172 0.0176
Leishmania major beta tubulin 0.0028 0.0064 0.0238
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0067 0.0233 0.0535
Schistosoma mansoni notch 0.0028 0.0063 0.0064
Echinococcus granulosus protein jagged 1 0.0028 0.0063 0.0064
Schistosoma mansoni chromobox protein 0.0071 0.0248 0.0254
Echinococcus multilocularis tubulin alpha chain 0.0053 0.017 0.0174
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0232 0.0862
Schistosoma mansoni alpha glucosidase 0.0037 0.01 0.0102
Brugia malayi TAR-binding protein 0.0262 0.108 0.1489
Leishmania major alpha tubulin 0.0053 0.017 0.0631
Leishmania major beta tubulin 0.0028 0.0064 0.0238
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0042 0.0344
Onchocerca volvulus 0.0027 0.0058 0.0058
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0127 0.0493 0.0505
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0027 0.0058 0.006
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0363 0.295
Loa Loa (eye worm) tubulin alpha 2 0.0024 0.0046 0.0121
Loa Loa (eye worm) hypothetical protein 0.0027 0.0058 0.0153
Onchocerca volvulus 0.014 0.055 0.055
Brugia malayi Tubulin beta-1 chain 0.0028 0.0064 0.0088
Brugia malayi tubulin alpha chain - mouse 0.0053 0.017 0.0234
Onchocerca volvulus 0.0023 0.0042 0.0042
Trypanosoma brucei beta tubulin 0.0028 0.0064 0.0238
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0248 0.0568
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.002 0.0045
Brugia malayi SET domain containing protein 0.0017 0.0014 0.002
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0316 0.1317 0.4867
Echinococcus multilocularis Tubulin alpha 1 chain 0.0053 0.017 0.0174
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0017 0.0012
Leishmania major beta tubulin 0.0028 0.0064 0.0238
Echinococcus granulosus tumor protein p63 0.0376 0.1575 0.1615
Loa Loa (eye worm) hypothetical protein 0.014 0.055 0.1439
Brugia malayi CHE-14 protein 0.0042 0.0122 0.0168
Loa Loa (eye worm) hypothetical protein 0.0097 0.0363 0.0948
Echinococcus multilocularis protein dispatched 1 0.0047 0.0147 0.0151
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Schistosoma mansoni hypothetical protein 0.0027 0.0058 0.006
Leishmania major alpha tubulin 0.0053 0.017 0.0631
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0209 0.051
Onchocerca volvulus 0.0016 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0058 0.0153
Schistosoma mansoni tar DNA-binding protein 0.0262 0.108 0.1107
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Schistosoma mansoni hypothetical protein 0.0028 0.0063 0.0064
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0316 0.1317 0.3715
Loa Loa (eye worm) notch protein 0.0028 0.0063 0.0164
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0058 0.006
Brugia malayi Cadherin domain containing protein 0.0028 0.0063 0.0087
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.1034 0.237
Toxoplasma gondii TIM10 family protein, putative 0.0053 0.0172 0.0414
Onchocerca volvulus 0.0184 0.0739 0.0739
Echinococcus multilocularis peroxisome assembly protein 26 0.0053 0.017 0.0174
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0119 0.0971
Echinococcus multilocularis tubulin subunit beta 0.0028 0.0064 0.0065
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0126 0.0289
Trypanosoma cruzi hypothetical protein 0.0067 0.0233 0.0868
Echinococcus granulosus tubulin alpha 1C chain 0.0053 0.017 0.0174
Trichomonas vaginalis tubulin beta chain, putative 0.0053 0.017 0.0389
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.01 0.0229
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0058 0.006
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0568 0.1486
Echinococcus granulosus Tolloid protein 1 0.0074 0.0261 0.0267
Echinococcus granulosus beta tubulin 0.0028 0.0064 0.0065
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0363 0.05
Mycobacterium ulcerans glutaminase 0.0277 0.1146 0.2988
Leishmania major beta tubulin 0.0028 0.0064 0.0238
Echinococcus multilocularis Tubulin beta 2C chain 0.0028 0.0064 0.0065
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Plasmodium falciparum telomerase reverse transcriptase 0.0631 0.2688 1
Echinococcus multilocularis GPCR, family 2 0.0049 0.0153 0.0157
Chlamydia trachomatis protoporphyrinogen oxidase 0.0062 0.0212 0.1504
Trypanosoma brucei epsilon tubulin 0.0028 0.0064 0.0238
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.1229 0.2819
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0212 0.0732
Leishmania major ATP-dependent phosphofructokinase 0.0121 0.0466 0.1735
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.057 1
Echinococcus multilocularis protein jagged 1 0.0028 0.0063 0.0064
Loa Loa (eye worm) hypothetical protein 0.0062 0.0212 0.0555
Brugia malayi Trypsin family protein 0.0027 0.0058 0.0081
Leishmania major beta tubulin 0.0028 0.0064 0.0238
Mycobacterium ulcerans hypothetical protein 0.0027 0.0058 0.0111
Onchocerca volvulus 0.1015 0.436 0.436
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0083 0.0509
Echinococcus multilocularis lysine specific demethylase 6a 0.0034 0.0088 0.009
Trypanosoma brucei alpha tubulin 0.0053 0.017 0.0631
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0067 0.0233 0.0322
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0526 0.0539
Echinococcus granulosus muscleblind protein 0.0489 0.2067 0.2119
Trypanosoma cruzi hypothetical protein, conserved 0.0097 0.0363 0.135
Echinococcus granulosus GPCR family 2 0.0049 0.0153 0.0157
Onchocerca volvulus 0.0028 0.0063 0.0063
Schistosoma mansoni egf-like domain protein 0.0074 0.0261 0.0267
Schistosoma mansoni alpha-glucosidase 0.0142 0.0559 0.0573
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0042 0.0068
Schistosoma mansoni slit 0.0028 0.0063 0.0064
Trypanosoma brucei telomerase reverse transcriptase 0.0631 0.2688 1
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0208 0.0555
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0088 0.0327
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.1229 1
Mycobacterium ulcerans oxidoreductase 0.0062 0.0212 0.0518
Brugia malayi EGF-like domain containing protein 0.0028 0.0063 0.0087
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0122 0.0125
Echinococcus multilocularis lysine specific demethylase 5A 0.0127 0.0493 0.0505
Schistosoma mansoni septate junction protein 0.0028 0.0063 0.0064
Toxoplasma gondii alpha tubulin TUBA1 0.0053 0.017 0.0407
Entamoeba histolytica hypothetical protein 0.0035 0.0095 0.0771
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0466 0.107
Loa Loa (eye worm) BEN-1 protein 0.0028 0.0064 0.0167
Loa Loa (eye worm) hypothetical protein 0.0051 0.0162 0.0425
Loa Loa (eye worm) hypothetical protein 0.0184 0.0739 0.1934
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.002 0.0045
Loa Loa (eye worm) Ulp1 protease 0.0067 0.0233 0.061
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Trypanosoma brucei alpha tubulin, putative 0.0016 0.001 0.0039
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Onchocerca volvulus 0.0027 0.0058 0.0058
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0209 0.051
Brugia malayi Muscle positioning protein 4 0.0028 0.0063 0.0087
Mycobacterium ulcerans monoamine oxidase 0.0062 0.0212 0.0518
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0109 0.0112
Onchocerca volvulus 0.0184 0.0739 0.0739
Echinococcus granulosus tubulin subunit beta 0.0028 0.0064 0.0065
Brugia malayi phosphofructokinase 0.0121 0.0466 0.0643
Brugia malayi RNA binding protein 0.0262 0.108 0.1489
Schistosoma mansoni hypothetical protein 0.0045 0.0137 0.014
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0058 0.006
Toxoplasma gondii beta-tubulin, putative 0.0028 0.0064 0.0004
Schistosoma mansoni cell polarity protein 0.0028 0.0063 0.0064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.0611 0.0843
Schistosoma mansoni hypothetical protein 0.0205 0.0831 0.0852
Loa Loa (eye worm) tubulin alpha-2 chain 0.0053 0.017 0.0444
Toxoplasma gondii RNA-directed DNA polymerase 0.0631 0.2688 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.0466 0.122
Entamoeba histolytica tubulin family protein 0.0028 0.0064 0.052
Schistosoma mansoni tubulin subunit alpha 0.0053 0.017 0.0174
Loa Loa (eye worm) hypothetical protein 0.004 0.0116 0.0304
Leishmania major alpha tubulin 0.0053 0.017 0.0631
Echinococcus granulosus peroxisome assembly protein 26 0.0053 0.017 0.0174
Echinococcus multilocularis JmjC domain containing protein 4 0.0034 0.0088 0.009
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0113 0.0259
Loa Loa (eye worm) hypothetical protein 0.0105 0.0399 0.1043
Echinococcus multilocularis tubulin beta 1 chain 0.0028 0.0064 0.0065
Toxoplasma gondii beta tubulin 0.0028 0.0064 0.0004
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.057 0.1464
Brugia malayi GCC2 and GCC3 family protein 0.0028 0.0063 0.0087
Schistosoma mansoni amine oxidase 0.0062 0.0212 0.0217
Schistosoma mansoni notch 0.0028 0.0063 0.0064
Giardia lamblia Gamma tubulin 0.0028 0.0064 0.0004
Loa Loa (eye worm) hypothetical protein 0.0034 0.0088 0.023
Leishmania major alpha tubulin 0.0053 0.017 0.0631
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0097 0.0363 0.1297
Trichomonas vaginalis tubulin, putative 0.0016 0.001 0.0024
Echinococcus granulosus enteropeptidase 0.0027 0.0058 0.006
Onchocerca volvulus 0.0184 0.0739 0.0739
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0073 0.0039
Trichomonas vaginalis tubulin epsilon chain, putative 0.0053 0.017 0.0389
Trypanosoma brucei epsilon tubulin 0.0028 0.0064 0.0238
Brugia malayi Calcium binding EGF domain containing protein 0.0028 0.0063 0.0087
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0129 0.05 0.1665
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Echinococcus granulosus tubulin beta 4A class IVa 0.0028 0.0064 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.05 0.0513
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0067 0.0233 0.0535
Loa Loa (eye worm) alpha-tubulin 0.0053 0.017 0.0444
Brugia malayi hypothetical protein 0.0027 0.0058 0.0081
Schistosoma mansoni hypothetical protein 0.0049 0.0153 0.0157
Trichomonas vaginalis tubulin beta chain, putative 0.0053 0.017 0.0389
Leishmania major alpha tubulin 0.0053 0.017 0.0631
Brugia malayi tubulin alpha-2 chain 0.0053 0.017 0.0234
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0062 0.0212 0.0518
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0083 0.0076
Loa Loa (eye worm) glutaminase 2 0.0277 0.1146 0.2996
Brugia malayi alpha-tubulin 0.0053 0.017 0.0234
Trichomonas vaginalis tubulin epsilon chain, putative 0.0053 0.017 0.0389
Brugia malayi Muscleblind-like protein 0.0489 0.2067 0.2851
Echinococcus multilocularis fat cadherin tumor suppressor 0.0028 0.0063 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0658 0.1509
Schistosoma mansoni tubulin subunit alpha 0.0053 0.017 0.0174
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.01 0.0102
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0209 0.0214
Schistosoma mansoni hypothetical protein 0.0028 0.0063 0.0064
Trypanosoma cruzi epsilon tubulin, putative 0.0028 0.0064 0.0238
Brugia malayi Telomerase reverse transcriptase 0.168 0.7252 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0028 0.0064 0.0147
Echinococcus multilocularis tubulin alpha chain 0.0053 0.017 0.0174
Echinococcus granulosus tubulin alpha chain 0.0053 0.017 0.0174
Echinococcus granulosus glycoprotein Antigen 5 0.0027 0.0058 0.006
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0232 0.0237
Schistosoma mansoni hypothetical protein 0.0035 0.0095 0.0097
Trypanosoma brucei beta tubulin 0.0028 0.0064 0.0238
Entamoeba histolytica hypothetical protein 0.0035 0.0095 0.0771
Mycobacterium ulcerans dehydrogenase 0.0062 0.0212 0.0518
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.01 0.0229
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0058 0.006
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Brugia malayi hypothetical protein 0.002 0.0026 0.0036
Entamoeba histolytica hypothetical protein 0.0035 0.0095 0.0771
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.002 0.0045
Leishmania major hypothetical protein, conserved 0.0097 0.0363 0.135
Mycobacterium tuberculosis Conserved hypothetical protein 0.0062 0.0212 0.0569
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0122 0.0125
Schistosoma mansoni hypothetical protein 0.0097 0.0363 0.0372
Trypanosoma cruzi UDP-galactopyranose mutase 0.0062 0.0212 0.0789
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0058 0.006
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0088 0.023
Loa Loa (eye worm) hypothetical protein 0.0062 0.0212 0.0555
Echinococcus multilocularis tubulin alpha 0.0028 0.0064 0.0065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0526 0.0539
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.1229 0.2819
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.1034 0.237
Leishmania major alpha tubulin 0.0053 0.017 0.0631
Onchocerca volvulus Slit protein homolog 0.0028 0.0063 0.0063
Trypanosoma brucei alpha tubulin 0.0053 0.017 0.0631
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0363 0.0372
Echinococcus multilocularis 0.0062 0.0212 0.0217
Echinococcus granulosus Tubulin alpha 1 chain 0.0053 0.017 0.0174
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.0659 0.0908
Brugia malayi Calcium binding EGF domain containing protein 0.0028 0.0063 0.0087
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0363 0.0372
Brugia malayi ShTK domain containing protein 0.0184 0.0739 0.1019
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0064 0.0147
Plasmodium vivax JmjC domain containing protein 0.0034 0.0088 0.0267
Giardia lamblia Fructose-bisphosphate aldolase 0.0296 0.1229 0.4442
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0073 0.0212
Brugia malayi glutaminase DH11.1 0.0277 0.1146 0.158
Echinococcus granulosus Tubulin beta 2C chain 0.0028 0.0064 0.0065
Trichomonas vaginalis tubulin epsilon chain, putative 0.0028 0.0064 0.0147
Onchocerca volvulus 0.0095 0.0356 0.0356
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0209 0.056
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0251 0.1034 0.1425
Leishmania major beta tubulin 0.0028 0.0064 0.0238
Trypanosoma brucei alpha tubulin 0.0053 0.017 0.0631
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0058 0.006
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0083 0.0076
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0568 0.1486
Onchocerca volvulus 0.0062 0.0212 0.0212
Brugia malayi Calcium binding EGF domain containing protein 0.0028 0.0063 0.0087
Trichomonas vaginalis tubulin beta chain, putative 0.0053 0.017 0.0389
Loa Loa (eye worm) hypothetical protein 0.0074 0.0261 0.0682
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0658 0.1509
Echinococcus multilocularis chromobox protein 1 0.0071 0.0248 0.0254
Loa Loa (eye worm) tubulin alpha chain 0.0053 0.017 0.0444
Echinococcus granulosus geminin 0.0205 0.0831 0.0852
Loa Loa (eye worm) hypothetical protein 0.0074 0.0261 0.0682
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0095 0.0097
Echinococcus multilocularis neurogenic locus protein delta 0.0028 0.0063 0.0064
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0232 0.1885
Loa Loa (eye worm) hypothetical protein 0.0045 0.0137 0.0358
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.0466 0.1735
Loa Loa (eye worm) hypothetical protein 0.0027 0.0058 0.0153
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0316 0.1317 0.5
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0209 0.0558
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.0466 0.1735
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0042 0.0157
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.01 0.0229
Brugia malayi hypothetical protein 0.0035 0.0095 0.0131
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0208 0.0214
Loa Loa (eye worm) hypothetical protein 0.0097 0.0363 0.0949
Schistosoma mansoni alpha tubulin 0.0053 0.017 0.0174
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.1229 0.2819
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.0611 0.1598
Schistosoma mansoni laminin gamma-3 chain 0.0028 0.0063 0.0064
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0043
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0122 0.0125
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0262 0.108 0.2823
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.01 0.0138
Echinococcus granulosus notch 0.0028 0.0063 0.0064
Schistosoma mansoni glutaminase 0.0277 0.1146 0.1174
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0083 0.0248
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0042 0.0068
Echinococcus granulosus neural cadherin 0.0028 0.0063 0.0064
Brugia malayi amine oxidase, flavin-containing family protein 0.0062 0.0212 0.0293
Loa Loa (eye worm) hypothetical protein 0.004 0.0113 0.0295
Brugia malayi 6-phosphofructokinase 0.0121 0.0466 0.0643
Echinococcus granulosus neurogenic locus notch protein 0.0028 0.0063 0.0064
Echinococcus multilocularis Tubulin alpha 1 chain 0.0053 0.017 0.0174
Brugia malayi Delta serrate ligand family protein 0.0028 0.0063 0.0087
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0126 0.0126
Leishmania major hypothetical protein, conserved 0.003 0.0073 0.0272
Plasmodium falciparum protoporphyrinogen oxidase 0.0062 0.0212 0.0732
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.004 0.0116 0.0266
Trichomonas vaginalis tubulin alpha chain, putative 0.0028 0.0064 0.0147
Echinococcus multilocularis hypothetical protein 0.0053 0.017 0.0174
Echinococcus granulosus 6 phosphofructokinase 0.0121 0.0466 0.0478
Loa Loa (eye worm) tubulin gamma chain 0.0028 0.0064 0.0167
Loa Loa (eye worm) hypothetical protein 0.014 0.055 0.1439
Echinococcus granulosus histone lysine methyltransferase setb 0.0129 0.05 0.0513
Trypanosoma brucei protein kinase, putative 0.0062 0.0208 0.0775
Leishmania major alpha tubulin 0.0053 0.017 0.0631
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0083 0.0509
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0027 0.0058 0.006
Loa Loa (eye worm) hypothetical protein 0.0049 0.0153 0.04
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.01 0.0229
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0043
Trichomonas vaginalis tubulin gamma chain, putative 0.0028 0.0064 0.0147
Trypanosoma cruzi beta tubulin, putative 0.0028 0.0064 0.0238
Brugia malayi Trypsin family protein 0.0027 0.0058 0.0081
Echinococcus granulosus Tubulin beta 2C chain 0.0028 0.0064 0.0065
Entamoeba histolytica tubulin alpha-1 chain 0.0053 0.017 0.1381
Loa Loa (eye worm) hypothetical protein 0.0023 0.0042 0.011
Loa Loa (eye worm) Notch2 0.0028 0.0063 0.0164
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0073 0.0212
Brugia malayi Common central domain of tyrosinase family protein 0.0184 0.0739 0.1019
Loa Loa (eye worm) hypothetical protein 0.0031 0.0076 0.0198
Schistosoma mansoni hypothetical protein 0.0205 0.0831 0.0852
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0122 0.0279
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0027 0.0058 0.006
Brugia malayi EGF-like domain containing protein 0.0028 0.0063 0.0087
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0042 0.0068
Onchocerca volvulus 0.0028 0.0063 0.0063
Echinococcus multilocularis 6 phosphofructokinase 0.0121 0.0466 0.0478
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0058 0.006
Onchocerca volvulus 0.0097 0.0363 0.0363
Trichomonas vaginalis tubulin, putative 0.0016 0.001 0.0024
Brugia malayi SWIRM domain containing protein 0.0062 0.0212 0.0293
Echinococcus granulosus tubulin alpha chain 0.0053 0.017 0.0174
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.002 0.0045
Loa Loa (eye worm) ShTK domain-containing protein 0.0184 0.0739 0.1934
Toxoplasma gondii alpha-tubulin I, putative 0.0053 0.017 0.0407
Schistosoma mansoni tar DNA-binding protein 0.0262 0.108 0.1107
Schistosoma mansoni protein phosphatase 2C 0.0034 0.0088 0.009
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0095 0.0097
Echinococcus granulosus neurogenic locus protein delta 0.0028 0.0063 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.05 0.0513
Plasmodium falciparum cysteine repeat modular protein 1 0.0097 0.0363 0.1297
Trypanosoma brucei alpha tubulin 0.0053 0.017 0.0631
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0122 0.0318
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.002 0.0045
Echinococcus multilocularis Tubulin beta 2C chain 0.0028 0.0064 0.0065
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0028 0.0064 0.0004
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0251 0.1034 0.2703
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0058 0.006
Leishmania major beta tubulin 0.0028 0.0064 0.0238
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0045 0.0137 0.014
Echinococcus multilocularis tubulin alpha chain 0.0053 0.017 0.0174
Echinococcus multilocularis fibropellin Ia 0.0028 0.0063 0.0064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.0526 0.0539
Schistosoma mansoni hypothetical protein 0.0027 0.0058 0.006
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0261
Schistosoma mansoni tubulin subunit beta 0.0028 0.0064 0.0065
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0209 0.051
Plasmodium falciparum tubulin epsilon chain, putative 0.0028 0.0064 0.0177
Brugia malayi Heterochromatin protein 1 0.0071 0.0248 0.0342
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.1034 0.237
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0074 0.0261 0.0682
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0062 0.0212 0.0732
Schistosoma mansoni tubulin subunit beta 0.0028 0.0064 0.0065
Echinococcus multilocularis laminin 0.0074 0.0261 0.0267
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0184 0.0739 0.1019
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0823 0.3524 1
Loa Loa (eye worm) tubulin beta-1 chain 0.0028 0.0064 0.0167
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0184 0.0739 0.1019
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.01 0.0814
Trichomonas vaginalis glutaminase, putative 0.0277 0.1146 0.2628
Plasmodium vivax tubulin gamma chain, putative 0.0028 0.0064 0.0177
Loa Loa (eye worm) TK/ROR protein kinase 0.0097 0.0363 0.0949
Schistosoma mansoni hypothetical protein 0.004 0.0115 0.0118
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0659 0.0675
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0184 0.0739 0.1019
Loa Loa (eye worm) RNA binding protein 0.0262 0.108 0.2823
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0466 0.3795
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0232 0.0606
Onchocerca volvulus 0.0184 0.0739 0.0739
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.1229 1
Schistosoma mansoni tubulin subunit alpha 0.0053 0.017 0.0174
Plasmodium vivax tubulin alpha chain, putative 0.0053 0.017 0.0573
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0892 0.3824 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.01 0.0372
Trypanosoma cruzi alpha tubulin, putative 0.0053 0.017 0.0631
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0316 0.1317 0.3441
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0208 0.0214
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0042 0.0068
Echinococcus granulosus expressed conserved protein 0.0091 0.0337 0.0345
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.01 0.0229
Giardia lamblia Telomerase catalytic subunit 0.0631 0.2688 1
Schistosoma mansoni hypothetical protein 0.0028 0.0063 0.0064
Echinococcus granulosus expressed protein 0.0053 0.0172 0.0176
Brugia malayi RNA recognition motif domain containing protein 0.0262 0.108 0.1489
Brugia malayi hypothetical protein 0.014 0.055 0.0759
Echinococcus granulosus protein jagged 2 0.0028 0.0063 0.0064
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.01 0.0229
Echinococcus granulosus lysine specific demethylase 5A 0.0128 0.05 0.0512
Loa Loa (eye worm) hypothetical protein 0.0027 0.0058 0.0153
Brugia malayi Tubulin beta chain 0.0016 0.001 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0042 0.0068
Brugia malayi jmjC domain containing protein 0.0034 0.0088 0.0121
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0886 0.3796 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.01 0.0229
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0035 0.0095 0.0097
Echinococcus multilocularis tubulin alpha 3 chain 0.0053 0.017 0.0174
Schistosoma mansoni chromobox protein 0.0071 0.0248 0.0254
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0027 0.0058 0.006
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0088 0.023
Loa Loa (eye worm) TAR-binding protein 0.0262 0.108 0.2823
Loa Loa (eye worm) hypothetical protein 0.0027 0.0058 0.0153
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0062 0.0212 0.0217
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0058 0.006
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0212 0.0732
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0526 0.0539
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.0659 0.1723
Echinococcus granulosus slit 2 protein 0.0028 0.0063 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.01 0.0372
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0466 0.3795
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0067 0.0176
Trichomonas vaginalis tubulin, putative 0.0028 0.0064 0.0147
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0095 0.0097
Echinococcus granulosus tar DNA binding protein 0.0262 0.108 0.1107
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0028 0.0063 0.0087
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0129 0.05 0.0513
Brugia malayi Tubulin gamma chain 0.0028 0.0064 0.0088
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0232 0.0862
Loa Loa (eye worm) hypothetical protein 0.0489 0.2067 0.5407
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.01 0.0372
Brugia malayi Calcium binding EGF domain containing protein 0.0074 0.0261 0.036
Brugia malayi notch-like transmembrane receptor 0.0028 0.0063 0.0087
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0016 0.001 0.0024
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0126 0.0289
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0658 0.1509
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0153 0.0157
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0153 0.0211
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0083 0.019
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0208 0.0545
Schistosoma mansoni tar DNA-binding protein 0.0262 0.108 0.1107
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0083 0.019
Schistosoma mansoni jumonji domain containing protein 0.0034 0.0088 0.009
Echinococcus multilocularis Tolloid protein 1 0.0074 0.0261 0.0267
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0184 0.0739 0.1019
Echinococcus granulosus Tubulin alpha 1 chain 0.0053 0.017 0.0174
Trypanosoma brucei beta tubulin 0.0028 0.0064 0.0238
Giardia lamblia Beta tubulin 0.0028 0.0064 0.0004
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0466 0.107
Schistosoma mansoni phd/f-box containing protein 0.0034 0.0088 0.009
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0164
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0034 0.0088 0.009
Schistosoma mansoni tyrosinase precursor 0.0184 0.0739 0.0758
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.1034 0.237
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0063 0.0143
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0631 0.2688 1
Echinococcus granulosus tissue type plasminogen activator 0.0097 0.0363 0.0372
Loa Loa (eye worm) hypothetical protein 0.0074 0.0261 0.0682
Entamoeba histolytica tubulin gamma chain 0.0028 0.0064 0.052
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0121 0.0466 0.1293
Plasmodium falciparum alpha tubulin 1 0.0053 0.017 0.0573
Echinococcus granulosus Tubulin beta 2C chain 0.0028 0.0064 0.0065
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0134 0.0526 0.1375
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0209 0.0214
Trypanosoma brucei beta tubulin 0.0028 0.0064 0.0238

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 22.803 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 35.775 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to BJeLR RAS-Dependent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
EC50 (functional) > 150 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT-LT-ST RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
Potency (functional) 1.3115 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 5.0119 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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