TDR Targets

Basic information

Technical information

TDR Targets ID: 1405398
Name: 2-(4-ethoxy-3-methoxyphenyl)-1-(4-methoxyphen yl)-4-oxo-6-sulfanyl-2,3-dihydropyrimidine-5- carbonitrile
MW: 411.474 | Formula: C21H21N3O4S
H donors: 1 H acceptors: 2 LogP: 3.43 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1OC)C1NC(=O)C(=C(N1c1ccc(cc1)OC)S)C#N
InChi: 1S/C21H21N3O4S/c1-4-28-17-10-5-13(11-18(17)27-3)19-23-20(25)16(12-22)21(29)24(19)14-6-8-15(26-2)9-7-14/h5-11,19,29H,4H2,1-3H3,(H,23,25)
InChiKey: NJLLDFWHGQSEIE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(4-ethoxy-3-methoxy-phenyl)-1-(4-methoxyphenyl)-4-oxo-6-sulfanyl-2,3-dihydropyrimidine-5-carbonitrile
2-(4-ethoxy-3-methoxyphenyl)-6-mercapto-1-(4-methoxyphenyl)-4-oxo-2,3-dihydropyrimidine-5-carbonitrile
2-(4-ethoxy-3-methoxy-phenyl)-4-keto-6-mercapto-1-(4-methoxyphenyl)-2,3-dihydropyrimidine-5-carbonitrile
2-(4-Ethoxy-3-methoxy-phenyl)-6-mercapto-1-(4-methoxy-phenyl)-4-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile
MLS000529408
SMR000121883
BAS 09637027
ST5140025

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	huntingtin	Starlite/ChEMBL	No references
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references
Giardia intestinalis	Putative fructose-1,6-bisphosphate aldolase	Starlite/ChEMBL	No references
Homo sapiens	neuropeptide S receptor 1	Starlite/ChEMBL	No references
Homo sapiens	multiple endocrine neoplasia I		No references
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references
Homo sapiens	bromodomain adjacent to zinc finger domain, 2B	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Onchocerca volvulus	Huntingtin homolog	Get druggable targets OG5_132837	All targets in OG5_132837
Schistosoma japonicum	Menin, putative	Get druggable targets OG5_133913	All targets in OG5_133913
Echinococcus multilocularis	neuropeptide s receptor	Get druggable targets OG5_136011	All targets in OG5_136011
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Onchocerca volvulus	Huntingtin homolog	Get druggable targets OG5_132837	All targets in OG5_132837
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Echinococcus multilocularis	neuropeptide receptor A26	Get druggable targets OG5_136011	All targets in OG5_136011
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_133913	All targets in OG5_133913
Echinococcus granulosus	neuropeptide s receptor	Get druggable targets OG5_136011	All targets in OG5_136011
Echinococcus multilocularis	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Giardia lamblia	Fructose-bisphosphate aldolase	Get druggable targets OG5_129214	All targets in OG5_129214
Echinococcus granulosus	neuropeptide receptor A26	Get druggable targets OG5_136011	All targets in OG5_136011
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	Cleft lip and palate transmembrane protein 1-like protein, putative	Get druggable targets OG5_131570	All targets in OG5_131570
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Get druggable targets OG5_136011	All targets in OG5_136011
Schistosoma japonicum	ko:K01549 ATP synthase [EC3.6.3.14], putative	Get druggable targets OG5_131570	All targets in OG5_131570
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Brugia malayi	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Schistosoma japonicum	Conserved hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131570	All targets in OG5_131570
Treponema pallidum	fructose-bisphosphate aldolase	Get druggable targets OG5_129214	All targets in OG5_129214
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	25.5 %
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	25.8 %
Candida albicans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	358 aa	22.6 %
Candida albicans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	358 aa	22.6 %
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %
Mycobacterium ulcerans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	26.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0276	0.0941
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0141	0.2803
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0182	0.0399
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0057	0.0052
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0007	0.001
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.003	0.0141	0.1322
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0343	0.6932
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0137	0.2718
Echinococcus granulosus	MAM	0.0016	0.0053	0.0106
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0057	0.0181
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0182	0.1268
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0005	0.001
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0137	0.0291
Schistosoma mansoni	serine/threonine protein kinase	0.0734	0.4568	1
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0182	0.1268
Echinococcus multilocularis	snurportin 1	0.0309	0.1898	0.1895
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0023	0.0051
Echinococcus multilocularis	RUN	0.0019	0.0075	0.007
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0057	0.0181
Onchocerca volvulus		0.0467	0.2894	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0008	0.0007	0.0007
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.018	0.0606
Schistosoma mansoni	glutamate synthase	0.0008	0.0005	0.001
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0057	0.0123
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0137	0.2724
Plasmodium falciparum	thioredoxin reductase	0.003	0.0141	0.2803
Trichomonas vaginalis	ran, putative	0.0021	0.0089	0.0293
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0182	0.039
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0411	0.2538	0.5556
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0182	0.1719
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0008	0.0007	0.0016
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0071	0.04	0.8102
Schistosoma mansoni	hypothetical protein	0.0008	0.0005	0.001
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0007	0.0069
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0043	0.0228	0.049
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0057	0.0181
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.0734	0.4568	1
Onchocerca volvulus	Huntingtin homolog	0.0148	0.0885	0.3058
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0008	0.0007	0.0061
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0141	0.2803
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0343	0.6929
Echinococcus granulosus	cathepsin l1	0.0011	0.0023	0.0041
Brugia malayi	F/Y-rich N-terminus family protein	0.0015	0.005	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0075	0.0164
Schistosoma mansoni	lozenge	0.0054	0.0293	0.0641
Brugia malayi	Pre-SET motif family protein	0.0411	0.2538	0.5556
Schistosoma mansoni	sulfide quinone reductase	0.0008	0.0005	0.001
Leishmania major	cathepsin L-like protease	0.0016	0.0057	0.1072
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.003	0.0141	0.2803
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0343	0.6932
Leishmania major	cathepsin L-like protease	0.0062	0.0343	0.6929
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0057	0.0241
Schistosoma mansoni	microtubule-associated protein tau	0.0667	0.4147	0.9079
Leishmania major	cathepsin L-like protease	0.0016	0.0057	0.1072
Echinococcus multilocularis	cysteine protease	0.0016	0.0057	0.0052
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.003	0.0141	0.2803
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0023	0.0065
Onchocerca volvulus		0.0016	0.0057	0.0195
Echinococcus multilocularis	mitogen activated protein kinase	0.0051	0.0276	0.0272
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0182	0.0399
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0276	0.0941
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0182	0.0616
Echinococcus multilocularis	cathepsin L	0.0008	0.0007	0.0003
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0036	0.018	0.0393
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0137	0.03
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0057	0.0181
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0023	0.0018
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0089	0.1733
Schistosoma mansoni	cpg binding protein	0.0035	0.0173	0.0379
Schistosoma mansoni	cathepsin F (C01 family)	0.0011	0.0023	0.0051
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.003	0.0141	0.2803
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.003	0.0141	0.0137
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0036	0.018	0.3591
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0089	0.1733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0057	0.0181
Trypanosoma cruzi	ISWI complex protein	0.0018	0.0071	0.1368
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0182	0.1355
Plasmodium vivax	glutathione reductase, putative	0.0085	0.0492	1
Leishmania major	cathepsin L-like protease	0.0016	0.0057	0.1072
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0051	0.0276	0.5573
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0011	0.0023	0.005
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0008	0.0005	0.0000061793
Schistosoma mansoni	ran	0.0021	0.0089	0.0195
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.008	0.0459	0.1005
Echinococcus multilocularis	geminin	0.017	0.1025	0.1021
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0195	0.1181	0.8385
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0182	0.0616
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0182	0.1268
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0217	0.1318	1
Schistosoma mansoni	zinc finger protein	0.0026	0.0116	0.0254
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0057	0.0181
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0057	0.0181
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0057	0.0124
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.2174	0.7509
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.0416	0.8436
Onchocerca volvulus		0.0016	0.0053	0.0181
Trichomonas vaginalis	apoptosis inducing factor, putative	0.0008	0.0005	0.0000061793
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0182	0.0399
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0057	0.0115
Schistosoma mansoni	glutamate synthase	0.0008	0.0005	0.001
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0011	0.0023	0.0018
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.008	0.0458	0.1002
Leishmania major	cathepsin L-like protease	0.0016	0.0057	0.1072
Onchocerca volvulus		0.0019	0.0075	0.0257
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.018	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0053	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0246	0.0539
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0008	0.0005	0.0000061793
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0075	0.007
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0008	0.0005	0.0000061793
Brugia malayi	beta-lactamase	0.0036	0.0182	0.0398
Schistosoma mansoni	polycystin 1-related	0.0019	0.0075	0.0164
Trypanosoma brucei	ISWI complex protein	0.0018	0.0071	0.1375
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0416	0.0911
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0057	0.0181
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0416	0.3978
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0182	0.1268
Echinococcus multilocularis	neuropeptide s receptor	0.0558	0.3466	0.3463
Trypanosoma cruzi	ISWI complex protein	0.0018	0.0071	0.1368
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.0008	0.0005	0.0008
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.2174	0.7509
Schistosoma mansoni	lipoxygenase	0.0019	0.0075	0.0164
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0137	0.2724
Trichomonas vaginalis	esterase, putative	0.0036	0.0182	0.0616
Brugia malayi	glutamate synthase	0.0008	0.0005	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0023	0.0051
Schistosoma mansoni	glutamate synthase	0.0008	0.0005	0.001
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0057	0.0123
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.0734	0.4568	0.4565
Leishmania major	trypanothione reductase	0.0085	0.0492	1
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0172	0.1039	0.7376
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.008	0.0459	0.1005
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.003	0.0141	0.2809
Schistosoma mansoni	cpg binding protein	0.0039	0.02	0.0438
Loa Loa (eye worm)	cysteine protease	0.0016	0.0057	0.0124
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0137	0.2718
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0182	0.1268
Brugia malayi	cathepsin L-like precursor	0.0011	0.0023	0.005
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0173	0.0378
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.003	0.0141	1
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0036	0.018	0.0807
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0343	0.6932
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0276	0.5573
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0008	0.0005	0.0000061793
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0089	0.174
Trypanosoma cruzi	cysteine peptidase, putative	0.0016	0.0057	0.1072
Plasmodium vivax	thioredoxin reductase, putative	0.0085	0.0492	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0023	0.0065
Toxoplasma gondii	ABC1 family protein	0.0036	0.0182	0.3646
Echinococcus multilocularis	cysteine protease	0.0016	0.0057	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0885	0.1938
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0007	0.0069
Leishmania major	cathepsin L-like protease	0.0062	0.0343	0.6929
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0007	0.0014
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0008	0.0005	0.0000061793
Trichomonas vaginalis	glutamate synthase, putative	0.0008	0.0005	0.0000061793
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0043	0.0228	0.0224
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0231	0.1407	1
Leishmania major	hypothetical protein, conserved	0.0036	0.0182	0.3646
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0343	0.6932
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0182	0.3646
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0057	0.0124
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0309	0.1898	0.4156
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.008	0.0458	0.0994
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0075	0.0154
Loa Loa (eye worm)	fibroinase	0.0016	0.0057	0.0124
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0182	0.0399
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0057	0.0123
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0057	0.0181
Toxoplasma gondii	NADPH-glutathione reductase	0.003	0.0141	0.2803
Schistosoma mansoni	apoptosis regulator bax	0.008	0.0458	0.1003
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.0416	0.2934
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0089	0.1733
Echinococcus multilocularis	zinc finger protein	0.0026	0.0116	0.0112
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0182	0.1268
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0182	0.1268
Echinococcus granulosus	dnaJ subfamily B	0.0494	0.3061	0.6698
Toxoplasma gondii	thioredoxin reductase	0.0085	0.0492	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0353	0.2174	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0074	0.0421	0.0416
Mycobacterium tuberculosis	Probable oxidoreductase	0.0217	0.1318	0.936
Echinococcus granulosus	mitogen activated protein kinase 3	0.0051	0.0276	0.0596
Loa Loa (eye worm)	hypothetical protein	0.0428	0.2646	0.5792
Plasmodium vivax	vivapain-2	0.0016	0.0057	0.1072
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.018	0.0175
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0011	0.0023	0.004
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.006	0.033	0.0325
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0057	0.0052
Trypanosoma cruzi	cysteine peptidase, putative	0.0008	0.0007	0.0061
Trichomonas vaginalis	set domain proteins, putative	0.0467	0.2894	1
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0007	0.0014
Brugia malayi	beta-lactamase family protein	0.0036	0.0182	0.0398
Brugia malayi	hypothetical protein	0.0019	0.0075	0.0163
Schistosoma mansoni	lipoxygenase	0.0053	0.029	0.0636
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0007	0.0014
Brugia malayi	MAP kinase sur-1	0.0051	0.0276	0.0604
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0416	0.3978
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0276	0.5573
Schistosoma mansoni	ran	0.0021	0.0089	0.0195
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0021	0.0085	0.0175
Loa Loa (eye worm)	ctsf protein	0.0016	0.0057	0.0124
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.003	0.0141	0.2809
Brugia malayi	glutathione reductase	0.0085	0.0492	0.1077
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.003	0.0141	0.2803
Schistosoma mansoni	zinc finger protein	0.0018	0.0071	0.0156
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0029	0.0139	0.0304
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.018	0.3596
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.003	0.0141	0.1322
Brugia malayi	SEA domain containing protein	0.0014	0.0046	0.01
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0007	0.0014
Brugia malayi	PHD-finger family protein	0.0032	0.0157	0.0342
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.0416	0.0902
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0492	0.1077
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.0343	0.6929
Schistosoma mansoni	bromodomain containing protein	0.0078	0.0448	0.0981
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0885	0.1938
Echinococcus granulosus	neuropeptide s receptor	0.0558	0.3466	0.7586
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.006	0.033	0.0722
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0089	0.1733
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0057	0.0124
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0023	0.004
Echinococcus multilocularis	MAM	0.0016	0.0053	0.0048
Mycobacterium tuberculosis	Probable reductase	0.0195	0.1181	0.8385
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0141	0.2803
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.006	0.033	0.0722
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0057	0.0181
Onchocerca volvulus		0.0014	0.0046	0.0158
Loa Loa (eye worm)	PHD-finger family protein	0.0025	0.0112	0.0245
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0007	0.0014
Onchocerca volvulus	Cathepsin F homolog	0.0016	0.0057	0.0195
Echinococcus multilocularis	microtubule associated protein 2	0.0667	0.4147	0.4144
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0053	0.0116
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.003	0.0141	0.2809
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0276	0.0941
Brugia malayi	NADPH:adrenodoxin oxidoreductase, mitochondrial precursor	0.0008	0.0005	0.0009
Schistosoma mansoni	hypothetical protein	0.0016	0.0053	0.0116
Entamoeba histolytica	Ran family GTPase	0.0021	0.0089	0.039
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0075	0.0154
Schistosoma mansoni	importin beta-1	0.0029	0.0137	0.03
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0016	0.0057	0.1072
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.018	0.3591
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0182	0.0399
Onchocerca volvulus		0.0019	0.0075	0.0257
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0089	0.039
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0182	0.0616
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0011	0.0023	0.005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0057	0.0181
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0008	0.0005	0.0009
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0008	0.0007	0.0016
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.2174	0.7509
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0057	0.0181
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.018	0.0606
Entamoeba histolytica	cysteine proteinase 2	0.0008	0.0007	0.0014
Plasmodium falciparum	glutathione reductase	0.003	0.0141	0.2803
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.003	0.0141	0.0308
Schistosoma mansoni	rab6-interacting	0.0019	0.0075	0.0164
Leishmania major	hypothetical protein, conserved	0.0018	0.0071	0.1368
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0182	0.1719
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0103	0.2012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0057	0.0181
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0007	0.0014
Toxoplasma gondii	cathepsin CPL	0.0016	0.0057	0.1072
Trichomonas vaginalis	mercuric reductase, putative	0.003	0.0141	0.0473
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0057	0.0181
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0057	0.0123
Onchocerca volvulus		0.0014	0.0046	0.0158
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0007	0.0014
Schistosoma mansoni	hypothetical protein	0.0494	0.3061	0.6701
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.0075	0.0154
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.008	0.0458	0.0994
Loa Loa (eye worm)	glutathione reductase	0.0085	0.0492	0.1078
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0007	0.0014
Schistosoma mansoni	hypothetical protein	0.0014	0.0046	0.0101
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0022	0.0092	0.02
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0182	0.1268
Schistosoma mansoni	hypothetical protein	0.0016	0.0053	0.0116
Entamoeba histolytica	cysteine proteinase, putative	0.0011	0.0023	0.0086
Echinococcus granulosus	snurportin 1	0.0309	0.1898	0.415
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0007	0.001
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0195	0.1181	0.8385
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0021	0.0085	0.008
Plasmodium vivax	unspecified product	0.0008	0.0007	0.0061
Loa Loa (eye worm)	DOMON domain-containing protein	0.0014	0.0046	0.0101
Mycobacterium tuberculosis	Probable dehydrogenase	0.0195	0.1181	0.8385
Brugia malayi	Pre-SET motif family protein	0.006	0.033	0.0721
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0007	0.0014
Brugia malayi	Bromodomain containing protein	0.0093	0.0537	0.1175
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0008	0.0005	0.0000061793
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.2174	1
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0008	0.0005	0.0000061793
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0053	0.029	0.0286
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0172	0.1039	0.788
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0343	0.6932
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0172	0.1039	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.003	0.0141	1
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0057	0.0123
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0036	0.018	0.0807
Loa Loa (eye worm)	programmed cell death 8	0.0008	0.0005	0.001
Schistosoma mansoni	hypothetical protein	0.017	0.1025	0.2244
Schistosoma mansoni	rab6-interacting	0.0019	0.0075	0.0164
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0343	0.6932
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0057	0.0181
Onchocerca volvulus		0.0016	0.0057	0.0195
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0343	0.6932
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.003	0.0141	0.2803
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0008	0.0007	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0036	0.018	0.0393
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0053	0.029	0.0627
Loa Loa (eye worm)	doublecortin family protein	0.0019	0.0075	0.0164
Schistosoma mansoni	sulfide quinone reductase	0.0008	0.0005	0.001
Onchocerca volvulus		0.0428	0.2646	0.9141
Loa Loa (eye worm)	apoptosis regulator protein	0.008	0.0458	0.1003
Schistosoma mansoni	hypothetical protein	0.008	0.0458	0.1003
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.003	0.0141	1
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0036	0.018	0.0175
Trypanosoma brucei	hypothetical protein, conserved	0.0008	0.0005	0.0008
Echinococcus multilocularis	Protein lozenge	0.0054	0.0293	0.0288
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0036	0.018	0.0393
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0051	0.0276	0.5573
Trypanosoma brucei	2,4-dienoyl-coa reductase-like protein	0.0008	0.0005	0.0008
Plasmodium falciparum	thioredoxin reductase	0.0085	0.0492	1
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.0075	0.1442
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0056	0.0309	0.624
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0343	0.6929
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0051	0.0276	0.5576
Trichomonas vaginalis	glutathione reductase, putative	0.003	0.0141	0.0473
Brugia malayi	RNA, U transporter 1	0.0082	0.0473	0.1034
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0182	0.0399
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0217	0.1318	0.936
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.003	0.0141	0.2803
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0057	0.0181
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0195	0.1181	0.8385
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0173	0.0379
Schistosoma mansoni	hypothetical protein	0.017	0.1025	0.2244
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0013	0.0036	0.0032
Onchocerca volvulus		0.0035	0.0173	0.0597
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.003	0.0141	0.2803
Brugia malayi	map kinase activated protein kinase protein 2	0.0734	0.4568	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0075	0.0164
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0057	0.0052
Echinococcus granulosus	cathepsin l1	0.0016	0.0057	0.0115
Onchocerca volvulus		0.0014	0.0046	0.0158
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0008	0.0007	0.0061
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0051	0.0276	0.0272
Giardia lamblia	Fructose-bisphosphate aldolase	0.0353	0.2174	1
Onchocerca volvulus	Huntingtin homolog	0.0148	0.0885	0.3058
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0007	0.0014
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.003	0.0141	0.1322
Loa Loa (eye worm)	pyridine nucleotide-disufhide oxidoreductase	0.0008	0.0005	0.001
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0276	0.0941
Trichomonas vaginalis	dihydrolipoamide dehydrogenase, putative	0.0008	0.0005	0.0000061793
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase family protein	0.0008	0.0005	0.0009
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0057	0.0181
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0013	0.0036	0.0069
Onchocerca volvulus		0.0016	0.0057	0.0195
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0057	0.0241
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0343	0.6932
Onchocerca volvulus		0.0016	0.0057	0.0195
Schistosoma mansoni	hypothetical protein	0.0018	0.0071	0.0156
Schistosoma mansoni	hypothetical protein	0.008	0.0458	0.1003
Loa Loa (eye worm)	bromodomain containing protein	0.0021	0.0089	0.0195
Echinococcus granulosus	cathepsin L	0.0008	0.0007	0.0007
Echinococcus granulosus	zinc finger protein	0.0026	0.0116	0.0245
Giardia lamblia	NADH oxidase lateral transfer candidate	0.003	0.0141	0.063
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0103	0.034
Echinococcus multilocularis	cpg binding protein	0.0039	0.02	0.0196
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0103	0.2012
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0053	0.0115
Onchocerca volvulus		0.0011	0.0023	0.0079
Echinococcus granulosus	ubiquitin specific protease 41	0.0036	0.018	0.0384
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.2174	0.7509
Trypanosoma brucei	trypanothione reductase	0.0085	0.0492	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0343	0.6932
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0182	0.1719
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0343	0.6932
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0182	0.1268
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.008	0.0458	0.1003
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0021	0.0085	0.0185
Echinococcus granulosus	RUN	0.0019	0.0075	0.0154
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0057	0.0311	0.0672
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0057	0.0181
Echinococcus multilocularis	ubiquitin specific protease 41	0.0036	0.018	0.0175
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.2174	0.7509
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.2174	0.7509
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0182	0.0616
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0103	0.034
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.003	0.0141	0.2803
Loa Loa (eye worm)	thioredoxin reductase	0.0085	0.0492	0.1078
Trypanosoma cruzi	cysteine proteinase, putative	0.0008	0.0007	0.0061
Plasmodium vivax	vivapain-3	0.0008	0.0007	0.0061
Echinococcus granulosus	histone lysine methyltransferase setb	0.008	0.0459	0.0996
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0416	0.3978
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0007	0.0014
Onchocerca volvulus		0.0036	0.0182	0.0629
Brugia malayi	Thioredoxin reductase	0.0085	0.0492	0.1077
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0057	0.0181
Echinococcus multilocularis	neuropeptide receptor A26	0.0558	0.3466	0.3463
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0022	0.0092	0.02
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0023	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0182	0.0399
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.003	0.0141	0.2803
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0141	0.2803
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.018	0.0384
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0016	0.0057	0.1072
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0057	0.0124
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0182	0.3646
Entamoeba histolytica	cysteine proteinase 1, putative	0.0008	0.0007	0.0014
Trypanosoma cruzi	trypanothione reductase, putative	0.0085	0.0492	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.2174	0.7509
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0182	0.1719
Treponema pallidum	NADH oxidase	0.003	0.0141	0.063
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0036	0.018	0.0393
Brugia malayi	Papain family cysteine protease containing protein	0.0008	0.0007	0.0016
Brugia malayi	Papain family cysteine protease containing protein	0.0008	0.0007	0.0016
Loa Loa (eye worm)	runx1	0.0054	0.0293	0.0641
Giardia lamblia	Kinase, CMGC MAPK	0.0051	0.0276	0.1253
Loa Loa (eye worm)	histone methyltransferase	0.0013	0.0036	0.0079
Loa Loa (eye worm)	TK/ALK protein kinase	0.0016	0.0053	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0046	0.0101
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.2174	0.7509
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.0276	0.0605
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0023	0.005
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.018	0.3591
Trichomonas vaginalis	glutamate synthase, putative	0.0008	0.0005	0.0000061793
Onchocerca volvulus		0.0036	0.0182	0.0629
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0021	0.0085	0.0185
Plasmodium vivax	vivapain-1	0.0008	0.0007	0.0061
Loa Loa (eye worm)	hypothetical protein	0.008	0.0459	0.1005
Onchocerca volvulus		0.0016	0.0057	0.0195
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0075	0.007
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.003	0.0141	0.2803
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0195	0.1181	0.8958
Schistosoma mansoni	disulfide oxidoreductase	0.0008	0.0005	0.001
Trypanosoma cruzi	trypanothione reductase, putative	0.003	0.0141	0.2803
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0085	0.0492	0.3478
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0007	0.0014
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0195	0.1181	0.8385
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0182	0.0399
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0074	0.0421	0.0912
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.008	0.0458	0.0454
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0051	0.0276	0.5573
Onchocerca volvulus		0.0016	0.0053	0.0181
Brugia malayi	Importin beta-1 subunit	0.0029	0.0137	0.0299
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0416	0.0911
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0023	0.005
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0343	0.6929
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.0416	0.8436
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0057	0.0181
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.003	0.0141	0.03
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0182	0.3651
Mycobacterium ulcerans	lipase LipD	0.0036	0.0182	0.1719
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0217	0.1318	0.936
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.2174	1
Leishmania major	cathepsin L-like protease	0.0016	0.0057	0.1072
Schistosoma mansoni	hypothetical protein	0.0025	0.0112	0.0245
Brugia malayi	hypothetical protein	0.0016	0.0053	0.0115
Trypanosoma cruzi	cysteine protease, putative	0.0008	0.0007	0.0061
Schistosoma mansoni	loxhd1	0.0019	0.0075	0.0164
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.0075	0.007
Schistosoma mansoni	hypothetical protein	0.008	0.0458	0.1003
Echinococcus granulosus	microtubule associated protein 2	0.0667	0.4147	0.9078
Echinococcus granulosus	geminin	0.017	0.1025	0.2236
Plasmodium vivax	SET domain protein, putative	0.006	0.033	0.6664
Leishmania major	cysteine peptidase A (CPA)	0.0016	0.0057	0.1072
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0036	0.018	0.0384
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0051	0.0276	0.5573
Onchocerca volvulus		0.0016	0.0057	0.0195
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0007	0.0014
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0057	0.0123
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0057	0.0115
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0007	0.0014
Schistosoma mansoni	hypothetical protein	0.0019	0.0075	0.0164
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0057	0.0181
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.006	0.033	0.6664
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0057	0.0195
Echinococcus granulosus	thioredoxin glutathione reductase	0.0086	0.0496	0.1076
Plasmodium vivax	vivapain-2	0.0016	0.0057	0.1072
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0137	0.0133
Echinococcus granulosus	cysteine protease	0.0008	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0309	0.1898	0.4156
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0057	0.0052
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0089	0.0185
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.008	0.0458	0.0454
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0182	0.1268
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.003	0.0141	0.2803
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0057	0.0124
Leishmania major	GTP-binding protein, putative	0.0021	0.0089	0.1733
Plasmodium falciparum	importin beta, putative	0.0029	0.0137	0.2718
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0182	0.0398
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0029	0.0139	0.0134
Echinococcus granulosus	fetal alzheimer antigen falz	0.0029	0.0139	0.0294
Onchocerca volvulus		0.0014	0.0046	0.0158
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0182	0.3646
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0264	0.0579
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0089	0.0085
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0057	0.0181
Brugia malayi	Bromodomain containing protein	0.0046	0.0246	0.0538
Trypanosoma brucei	pyridine nucleotide-disulphide oxidoreductase, putative	0.0008	0.0005	0.0008
Brugia malayi	hypothetical protein	0.0148	0.0885	0.1937
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0291	0.0638
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0016	0.0057	0.1072
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.003	0.0141	0.0975
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.0734	0.4568	1
Echinococcus granulosus	mitogen activated protein kinase	0.0051	0.0276	0.0596
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0141	0.2803
Onchocerca volvulus		0.0036	0.0182	0.0629
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0086	0.0496	0.0491
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0057	0.0123
Plasmodium falciparum	glutathione reductase	0.0085	0.0492	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0182	0.0399
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0182	0.0399
Trypanosoma brucei	NADPH:adrenodoxin oxidoreductase, mitochondrial, putative	0.0008	0.0005	0.0008
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0076	0.0431	0.0944
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.003	0.0141	0.2803
Onchocerca volvulus		0.0016	0.0057	0.0195
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0057	0.0181
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.0416	0.0412
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0182	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0046	0.0101
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0051	0.0276	0.5573
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.003	0.0141	0.2809
Onchocerca volvulus		0.0014	0.0046	0.0158
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0089	0.1733
Trypanosoma cruzi	cysteine proteinase, putative	0.0008	0.0007	0.0061
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0057	0.0195
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0182	0.0616
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.0075	0.1442
Brugia malayi	beta-lactamase family protein	0.0036	0.0182	0.0398
Brugia malayi	hypothetical protein	0.0428	0.2646	0.5792
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0057	0.0181
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0008	0.0005	0.0000061793
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0089	0.0194
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0057	0.0181
Loa Loa (eye worm)	hypothetical protein	0.008	0.0458	0.1003
Echinococcus granulosus	neuropeptide receptor A26	0.0558	0.3466	0.7586
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0008	0.0005	0.0000061793
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0089	0.0195
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0007	0.0014
Schistosoma mansoni	cpg binding protein	0.0039	0.02	0.0438
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0051	0.0276	0.0605
Leishmania major	cathepsin L-like protease	0.0062	0.0343	0.6929
Brugia malayi	Doublecortin family protein	0.0019	0.0075	0.0163
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0343	0.6932
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.003	0.0141	0.0309
Brugia malayi	Muscle positioning protein 4	0.0014	0.0046	0.01
Echinococcus granulosus	cpg binding protein	0.0039	0.02	0.0429
Brugia malayi	hypothetical protein	0.0019	0.0075	0.0163
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0057	0.0241
Trypanosoma brucei	NADH dehydrogenase	0.0008	0.0005	0.0008
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0182	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0428	0.2646	0.5792
Trypanosoma brucei	protein kinase, putative	0.0051	0.0276	0.5576
Onchocerca volvulus		0.0008	0.0005	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0053	0.0116
Entamoeba histolytica	hypothetical protein	0.0023	0.0103	0.0453
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0007	0.0014
Onchocerca volvulus		0.006	0.033	0.1138
Echinococcus multilocularis	dnaJ subfamily B	0.0494	0.3061	0.3058
Trypanosoma cruzi	major cysteine proteinase, putative	0.0048	0.026	0.5229
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0103	0.034
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.008	0.0459	0.0455
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0007	0.0014

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	133.68 uM	PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.7079 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	= 5.6234 um	PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ]	ChEMBL.	No reference
Potency (functional)	= 5.6234 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 9.9763 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	21.3313 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 24.9271 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	26.6795 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference
Potency (binding)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1561726

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1405398