Detailed information for compound 1451291

Basic information

Technical information
  • TDR Targets ID: 1451291
  • Name: 5-amino-1-(3-methylphenyl)-2-phenyl-2H-pyrrol e-3,3,4-tricarbonitrile
  • MW: 325.367 | Formula: C20H15N5
  • H donors: 1 H acceptors: 3 LogP: 3.13 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(N)N(C(C1(C#N)C#N)c1ccccc1)c1cccc(c1)C
  • InChi: 1S/C20H15N5/c1-14-6-5-9-16(10-14)25-18(15-7-3-2-4-8-15)20(12-22,13-23)17(11-21)19(25)24/h2-10,18H,24H2,1H3
  • InChiKey: SNTJIIZCJXPGLE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-amino-1-(3-methylphenyl)-2-phenyl-2-pyrroline-3,3,4-tricarbonitrile
  • MLS000079569
  • Oprea1_007466
  • STOCK3S-22485
  • SMR000041622

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0094 0.0596 0.0919
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.002 0.0071 0.0071
Trichomonas vaginalis protein transport protein sec7, putative 0.002 0.0071 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0079 0.0314
Loa Loa (eye worm) hypothetical protein 0.0095 0.0598 0.0923
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0038 0.0038
Echinococcus granulosus Protein Wnt-11b 0.0015 0.0031 0.0031
Leishmania major protein kinase, putative 0.0023 0.0087 0.0383
Brugia malayi regulator of G-protein signaling rgs-7 0.0095 0.0598 0.2589
Loa Loa (eye worm) hypothetical protein 0.0029 0.0133 0.0196
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0113 0.0806
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Echinococcus granulosus dnaJ subfamily B 0.0404 0.2784 0.2784
Echinococcus multilocularis WNT 0.0015 0.0031 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0598 0.2802
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.014 0.014
Entamoeba histolytica hypothetical protein 0.0095 0.0598 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1376 0.6445
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0333
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0276 0.1175
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0097 0.0614 0.0948
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0095 0.0598 0.2802
Loa Loa (eye worm) AGC/AKT protein kinase 0.0023 0.0087 0.0124
Schistosoma mansoni zinc finger protein 0.002 0.0071 0.0071
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1376 0.6445
Echinococcus granulosus regulator of G protein signaling 7 0.0095 0.0598 0.0598
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0095 0.0598 0.0598
Echinococcus granulosus cpg binding protein 0.003 0.014 0.014
Entamoeba histolytica ARF GTPase activating protein, putative 0.002 0.0071 0.00000016572
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Echinococcus granulosus snurportin 1 0.031 0.2124 0.2124
Schistosoma mansoni ran 0.0021 0.0079 0.0079
Brugia malayi Dynamin 0.002 0.0071 0.0278
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0821 0.5736 0.5736
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0099
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0079 0.0054
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0596 1
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0614 0.0614
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.002 0.0071 0.0071
Echinococcus multilocularis zinc finger transcription factor gli2 0.0334 0.2288 0.2288
Onchocerca volvulus 0.003 0.014 0.0458
Onchocerca volvulus 0.006 0.035 0.1842
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0099
Onchocerca volvulus Huntingtin homolog 0.0128 0.0831 0.5014
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.002 0.0071 0.0333
Brugia malayi Variant SH3 domain containing protein 0.002 0.0071 0.0278
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0079 0.0079
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0113 0.1006
Echinococcus multilocularis tumor protein p63 0.0408 0.2815 0.2815
Loa Loa (eye worm) syntrophin-1 0.002 0.0071 0.0099
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.002 0.0071 0.0071
Brugia malayi Probable ClpP-like protease 0.0094 0.0596 0.2579
Echinococcus granulosus regulator of G protein signaling 3 0.0095 0.0598 0.0598
Toxoplasma gondii protein kinase domain-containing protein 0.0023 0.0087 0.0307
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0366 0.0366
Onchocerca volvulus Huntingtin homolog 0.0128 0.0831 0.5014
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0038 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0333
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0042
Schistosoma mansoni hypothetical protein 0.002 0.0071 0.0071
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0235 0.0235
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0133 0.1479
Loa Loa (eye worm) hypothetical protein 0.0318 0.2178 0.3391
Brugia malayi PH domain containing protein 0.002 0.0071 0.0278
Leishmania major hypothetical protein, conserved 0.0026 0.0113 0.1006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0038 0.0047
Leishmania major serine/threonine-protein kinase a, putative 0.0023 0.0087 0.0383
Loa Loa (eye worm) rho-GTPase-activating 0.002 0.0071 0.0099
Loa Loa (eye worm) hypothetical protein 0.0128 0.0831 0.1286
Echinococcus granulosus regulator of G protein signaling 7 0.0095 0.0598 0.0598
Echinococcus multilocularis oxysterol binding protein 9 0.002 0.0071 0.0071
Loa Loa (eye worm) uncoordinated protein 104 0.002 0.0071 0.0099
Trichomonas vaginalis centaurin/arf, putative 0.002 0.0071 0.0333
Schistosoma mansoni hypothetical protein 0.0012 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0598 0.2802
Brugia malayi steroid hormone receptor 0.0021 0.0079 0.0314
Brugia malayi PH domain containing protein 0.002 0.0071 0.0278
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0099
Schistosoma mansoni cpg binding protein 0.003 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0095 0.0598 0.0923
Echinococcus granulosus Regulator of G protein signaling 20 0.0095 0.0598 0.0598
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0318 0.1363
Echinococcus granulosus Protein Wnt-111 0.0015 0.0031 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0333
Schistosoma mansoni rho gtpase activating protein 0.002 0.0071 0.0071
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0011 0.0011
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0492 0.0492
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0133 0.1185
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0079 0.0079
Echinococcus granulosus lamin dm0 0.0033 0.0158 0.0158
Echinococcus granulosus zinc finger transcription factor gli2 0.0334 0.2288 0.2288
Echinococcus multilocularis cpg binding protein 0.003 0.014 0.014
Brugia malayi hypothetical protein 0.0017 0.0048 0.0175
Schistosoma mansoni hypothetical protein 0.0205 0.1376 0.1376
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.1454 0.681
Schistosoma mansoni rhogef and pleckstrin domain protein 0.002 0.0071 0.0071
Onchocerca volvulus 0.0033 0.0158 0.0574
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0598 0.2802
Echinococcus multilocularis regulator of G protein signaling 7 0.0095 0.0598 0.0598
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.014 0.014
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Schistosoma mansoni regulator of G protein signaling 0.0095 0.0598 0.0598
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0133 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0598 0.2802
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0079 0.0112
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0113 0.1006
Brugia malayi Pre-SET motif family protein 0.003 0.014 0.0582
Loa Loa (eye worm) hypothetical protein 0.0021 0.0079 0.0112
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0095 0.0598 0.0923
Loa Loa (eye worm) Plekhf2 protein 0.002 0.0071 0.0099
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0087 0.0306
Schistosoma mansoni hypothetical protein 0.0043 0.0235 0.0235
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2135 1
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0023 0.0087 0.0383
Brugia malayi PH domain containing protein 0.002 0.0071 0.0278
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0113 0.0806
Brugia malayi Pleckstrin Homology Domain 0.002 0.0071 0.0278
Brugia malayi Regulator of G protein signaling domain containing protein 0.0095 0.0598 0.2589
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1385 0.2153
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0158 0.0659
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0079 0.0314
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0333
Echinococcus multilocularis rac serine:threonine kinase 0.0023 0.0087 0.0087
Echinococcus multilocularis Oxysterol binding protein 11 0.002 0.0071 0.0071
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0235 0.0235
Brugia malayi PH domain containing protein 0.002 0.0071 0.0278
Echinococcus multilocularis cytohesin 1 0.002 0.0071 0.0071
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1376 0.6445
Loa Loa (eye worm) PXA domain-containing protein 0.0095 0.0598 0.0923
Echinococcus granulosus oxysterol binding protein 9 0.002 0.0071 0.0071
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0079 0.0112
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0276 0.1175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0079 0.0112
Echinococcus granulosus pleckstrin y domain containing family A 0.002 0.0071 0.0071
Loa Loa (eye worm) oxysterol binding protein 0.002 0.0071 0.0099
Loa Loa (eye worm) variant SH3 domain-containing protein 0.002 0.0071 0.0099
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0099
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0079 0.0079
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0596 0.5
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0492 1
Brugia malayi ecdysteroid receptor 0.0021 0.0079 0.0314
Echinococcus granulosus oxysterol binding protein 1 0.002 0.0071 0.0071
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0318 0.0318
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Echinococcus granulosus beta 1 syntrophin 0.002 0.0071 0.0071
Brugia malayi Oxysterol binding protein 0.002 0.0071 0.0278
Brugia malayi Variant SH3 domain containing protein 0.002 0.0071 0.0278
Echinococcus granulosus regulator of G protein signaling 3 0.0095 0.0598 0.0598
Schistosoma mansoni axis inhibition protein axin 0.0095 0.0598 0.0598
Brugia malayi PH domain containing protein 0.002 0.0071 0.0278
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0038 0.0038
Brugia malayi nuclear hormone receptor 0.0021 0.0079 0.0314
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0037
Entamoeba histolytica hypothetical protein 0.0043 0.0235 0.3111
Echinococcus multilocularis Pleckstrin y 0.002 0.0071 0.0071
Trypanosoma cruzi NIMA-related kinase, putative 0.0023 0.0087 0.0383
Onchocerca volvulus 0.0033 0.0158 0.0574
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0099
Brugia malayi hypothetical protein 0.0128 0.0831 0.361
Schistosoma mansoni syntrophin 0.002 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.002 0.0071 0.0071
Entamoeba histolytica hypothetical protein 0.0095 0.0598 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0079 0.0314
Echinococcus granulosus intermediate filament protein 0.0033 0.0158 0.0158
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0492 0.0492
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0038
Schistosoma mansoni coup transcription factor 0.0021 0.0079 0.0079
Echinococcus granulosus DCC interacting protein 13 beta 0.002 0.0071 0.0071
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.2784 0.2784
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0079 0.0079
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0095 0.0598 0.0598
Echinococcus granulosus axis inhibition protein axin 0.0095 0.0598 0.0598
Schistosoma mansoni goodpasture antigen-binding protein 0.002 0.0071 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0079 0.0314
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0079 0.0079
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.002 0.0071 0.0071
Brugia malayi probable spectrin beta chain 0.002 0.0071 0.0278
Entamoeba histolytica hypothetical protein 0.0043 0.0235 0.3111
Echinococcus multilocularis wingless type MMTV integration site family 0.0015 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0033 0.0158 0.0235
Echinococcus multilocularis dynamin 1 0.002 0.0071 0.0071
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Echinococcus multilocularis axis inhibition protein axin 0.0095 0.0598 0.0598
Echinococcus granulosus expressed protein 0.0095 0.0598 0.0598
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0079 0.0079
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0158 0.1652
Schistosoma mansoni zinc finger protein 0.002 0.0071 0.0071
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0366 0.0366
Brugia malayi PH domain containing protein 0.002 0.0071 0.0278
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0079 0.0079
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0079 0.0079
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0079 0.0079
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Loa Loa (eye worm) hypothetical protein 0.0021 0.0079 0.0112
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.002 0.0071 0.0071
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0366 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0079 0.0112
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0023 0.0087 0.0409
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2135 1
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0079 0.0079
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0079 0.0187
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1376 0.6445
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0099
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0079 0.0079
Schistosoma mansoni axis inhibition protein axin 0.0095 0.0598 0.0598
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0079 0.0079
Echinococcus multilocularis wnt family member wnt11 2 0.0015 0.0031 0.0031
Echinococcus multilocularis beta adrenergic receptor kinase 0.0916 0.6407 0.6407
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0023 0.0087 0.0383
Echinococcus multilocularis protein Wnt 2 0.0015 0.0031 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0333
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0079 0.0079
Schistosoma mansoni dynamin 0.002 0.0071 0.0071
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.0087 0.0383
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0333
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0094 0.0554
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.002 0.0071 0.0071
Schistosoma mansoni lamin 0.0033 0.0158 0.0158
Brugia malayi Oxysterol-binding protein 0.002 0.0071 0.0278
Echinococcus granulosus protein Wnt 2 0.0015 0.0031 0.0031
Entamoeba histolytica protein kinase, putative 0.0023 0.0087 0.0306
Trichomonas vaginalis centaurin gamma, putative 0.002 0.0071 0.0333
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.0158 0.2648
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.002 0.0071 0.0071
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0079 0.0187
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Echinococcus multilocularis expressed protein 0.0095 0.0598 0.0598
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0079 0.0079
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0095 0.0598 0.0923
Schistosoma mansoni ran 0.0021 0.0079 0.0079
Echinococcus multilocularis lamin dm0 0.0033 0.0158 0.0158
Brugia malayi RNA, U transporter 1 0.0083 0.0513 0.2214
Loa Loa (eye worm) CWN-2 protein 0.0015 0.0031 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1376 0.6445
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0023 0.0087 0.0383
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0079 0.0079
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0596 0.0596
Schistosoma mansoni lamin 0.0033 0.0158 0.0158
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0318 0.0318
Brugia malayi nuclear receptor NHR-88 0.0021 0.0079 0.0314
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.2135 0.9326
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0011 0.0011
Schistosoma mansoni cpg binding protein 0.0028 0.0128 0.0128
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0099
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0158 0.2648
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2135 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0596 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.0831 0.1286
Entamoeba histolytica protein kinase, putative 0.0023 0.0087 0.0306
Brugia malayi Plekhf2 protein 0.002 0.0071 0.0278
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0037
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0079 0.0079
Schistosoma mansoni z-protein (S1r protein) 0.0095 0.0598 0.0598
Echinococcus granulosus pdz domain containing protein 0.002 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0095 0.0598 0.0923
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2135 1
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.002 0.0071 0.0071
Entamoeba histolytica hypothetical protein 0.0024 0.0094 0.0442
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0079 0.0314
Leishmania major GTP-binding protein, putative 0.0021 0.0079 0.0187
Echinococcus granulosus dynamin 1 0.002 0.0071 0.0071
Schistosoma mansoni wnt related 0.0015 0.0031 0.0031
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.002 0.0071 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0079 0.0314
Echinococcus multilocularis GPCR, family 2 0.0016 0.0038 0.0038
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0158 0.1652
Echinococcus multilocularis geminin 0.0205 0.1376 0.1376
Echinococcus granulosus Protein Wnt-04 0.0015 0.0031 0.0031
Echinococcus multilocularis Regulator of G protein signaling 20 0.0095 0.0598 0.0598
Schistosoma mansoni cpg binding protein 0.003 0.014 0.014
Schistosoma mansoni hypothetical protein 0.0034 0.0166 0.0166
Echinococcus multilocularis regulator of G protein signaling 3 0.0095 0.0598 0.0598
Onchocerca volvulus 0.0234 0.1586 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0008 0.0008
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0087 0.0306
Trichomonas vaginalis centaurin beta, putative 0.002 0.0071 0.0333
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0023 0.0087 0.0383
Loa Loa (eye worm) hypothetical protein 0.0318 0.2178 0.3391
Trichomonas vaginalis ran, putative 0.0021 0.0079 0.037
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0596 0.5
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.002 0.0071 0.0333
Schistosoma mansoni serine/threonine protein kinase 0.0916 0.6407 0.6407
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.002 0.0071 0.0071
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0023 0.0087 0.0383
Loa Loa (eye worm) hypothetical protein 0.0032 0.0154 0.0228
Echinococcus multilocularis calcium dependent secretion activator 1 0.002 0.0071 0.0071
Echinococcus multilocularis muscleblind protein 1 0.0318 0.2178 0.2178
Loa Loa (eye worm) zinc finger protein 0.0334 0.2288 0.3564
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0596 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0099
Loa Loa (eye worm) hypothetical protein 0.0049 0.0276 0.0419
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0318 0.0486
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0099
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0023 0.0087 0.0307
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.002 0.0071 0.0071
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Trichomonas vaginalis protein transport protein sec7, putative 0.002 0.0071 0.0333
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1586 0.7431
Brugia malayi wnt family protein 0.0015 0.0031 0.0103
Entamoeba histolytica hypothetical protein 0.0095 0.0598 1
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0094 0.0442
Echinococcus multilocularis Rho GTPase activating protein 24 0.002 0.0071 0.0071
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0095 0.0598 0.0598
Brugia malayi Wnt-2 protein precursor 0.0015 0.0031 0.0103
Brugia malayi hypothetical protein 0.002 0.0071 0.0278
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0023 0.0087 0.0383
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0023 0.0087 0.0383
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0166 0.0692
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.002 0.0071 0.0278
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0097 0.0614 0.2659
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Echinococcus multilocularis regulator of G protein signaling 0.0095 0.0598 0.0598
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.014 0.014
Echinococcus multilocularis Pleckstrin y 0.002 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0099
Entamoeba histolytica protein kinase, putative 0.0023 0.0087 0.0306
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0079 0.0079
Brugia malayi hypothetical protein 0.0043 0.0235 0.0997
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0079 0.015
Brugia malayi hypothetical protein 0.0095 0.0598 0.2589
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0128 0.0188
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0315 0.4652
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0333
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0333
Echinococcus granulosus muscleblind protein 0.0318 0.2178 0.2178
Entamoeba histolytica protein kinase, putative 0.0023 0.0087 0.0306
Entamoeba histolytica hypothetical protein 0.0043 0.0235 0.3111
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0079 0.0314
Onchocerca volvulus 0.0028 0.0128 0.0376
Brugia malayi Dynamin 0.002 0.0071 0.0278
Echinococcus granulosus myotubularin protein 13 0.002 0.0071 0.0071
Echinococcus multilocularis snurportin 1 0.031 0.2124 0.2124
Entamoeba histolytica protein kinase, putative 0.0023 0.0087 0.0306
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0333
Schistosoma mansoni hypothetical protein 0.002 0.0071 0.0071
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0361 0.0361
Echinococcus multilocularis pleckstrin y domain containing family A 0.002 0.0071 0.0071
Brugia malayi A-kinase anchor protein 10, precursor 0.0095 0.0598 0.2589
Echinococcus granulosus Oxysterol binding protein 11 0.002 0.0071 0.0071
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0094 0.0442
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0079 0.0314
Echinococcus multilocularis lamin 0.0033 0.0158 0.0158
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0276 0.0419
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0023 0.0087 0.0383
Entamoeba histolytica hypothetical protein 0.0043 0.0235 0.3111
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0133 0.1479
Echinococcus granulosus G protein coupled receptor kinase 1 0.0821 0.5736 0.5736
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0079 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0333
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0099
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0023 0.0087 0.0383
Brugia malayi Protein kinase domain containing protein 0.0023 0.0087 0.0349
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0039 0.0039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0318 0.0318
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0596 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0916 0.6407 1
Plasmodium vivax importin-beta 2, putative 0.0029 0.0133 0.1185
Schistosoma mansoni regulator of G protein signaling 0.0095 0.0598 0.0598
Entamoeba histolytica p21-activated kinase 0.0023 0.0087 0.0306
Brugia malayi wnt family protein 0.0015 0.0031 0.0103
Leishmania major protein kinase, putative 0.0023 0.0087 0.0383
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0038 0.0132
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0008 0.0008
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0492 0.2122
Brugia malayi regulator of G-protein signaling egl-10 0.0095 0.0598 0.2589
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0079 0.0054
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0021 0.0079 0.0112
Schistosoma mansoni regulator of G protein signaling 0.0095 0.0598 0.0598
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0038 0.0038
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0087 0.0087
Echinococcus multilocularis WNT 0.0015 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0079 0.0314
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0023 0.0087 0.0409
Schistosoma mansoni serine/threonine protein kinase 0.0916 0.6407 0.6407
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0079 0.0079
Schistosoma mansoni myotubularin-related protein 0.002 0.0071 0.0071
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0366 1
Brugia malayi wnt family protein 0.0015 0.0031 0.0103
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.2135 0.3324
Echinococcus granulosus serine/threonine protein kinase 0.0023 0.0087 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0333
Echinococcus granulosus calcium dependent secretion activator 1 0.002 0.0071 0.0071
Brugia malayi wnt family protein 0.0015 0.0031 0.0103
Brugia malayi hypothetical protein 0.0026 0.0113 0.0464
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0079 0.0314
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0099
Echinococcus granulosus geminin 0.0205 0.1376 0.1376
Loa Loa (eye worm) RGS-3 protein 0.0095 0.0598 0.0923
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0079 0.0314
Brugia malayi CXXC zinc finger family protein 0.0028 0.0128 0.0528
Brugia malayi Uncoordinated protein 104 0.002 0.0071 0.0278
Loa Loa (eye worm) hypothetical protein 0.0016 0.0039 0.0049
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0158 0.0235
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.1454 0.681
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0095 0.0598 0.0598
Brugia malayi PXA domain containing protein 0.0095 0.0598 0.2589
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0598 0.2802
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1376 0.6445
Loa Loa (eye worm) hypothetical protein 0.0095 0.0598 0.0923
Echinococcus granulosus protein Wnt 1 0.0015 0.0031 0.0031
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.002 0.0071 0.0071
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.002 0.0071 0.0333
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0596 0.0596
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0079 0.0079
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0087 0.0306
Schistosoma mansoni growth factor receptor-bound protein 0.002 0.0071 0.0071
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0079 0.0314
Trichomonas vaginalis kinesin light chain, putative 0.002 0.0071 0.0333
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.014 0.014
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Brugia malayi Regulator of G protein signaling domain containing protein 0.0095 0.0598 0.2589
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.002 0.0071 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0079 0.0112
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0079 0.0187
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0596 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0596 1
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0079 0.0079
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.014 0.014
Schistosoma mansoni hypothetical protein 0.0404 0.2784 0.2784
Schistosoma mansoni hypothetical protein 0.031 0.2124 0.2124
Echinococcus multilocularis Pleckstrin y 0.002 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0038
Echinococcus multilocularis regulator of G protein signaling 3 0.0095 0.0598 0.0598
Echinococcus multilocularis myotubularin protein 13 0.002 0.0071 0.0071
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.002 0.0071 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0318 0.0318
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0095 0.0598 0.0598
Plasmodium falciparum importin beta, putative 0.0029 0.0133 0.1185
Plasmodium vivax SET domain protein, putative 0.003 0.014 0.1321
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0087 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0333
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0079 0.0313
Echinococcus granulosus Pleckstrin domain containing protein family B 0.002 0.0071 0.0071
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0008 0.0008
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0492 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0113 0.1006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0079 0.0112
Entamoeba histolytica protein kinase, putative 0.0023 0.0087 0.0306
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0492 0.0756
Echinococcus multilocularis microtubule associated protein 2 0.1423 1 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0039 0.0039
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.014 0.1321
Schistosoma mansoni microtubule-associated protein tau 0.1423 1 1
Leishmania major folate/biopterin transporter, putative 0.0023 0.0087 0.0383
Schistosoma mansoni guanyl-nucleotide exchange factor 0.002 0.0071 0.0071
Entamoeba histolytica hypothetical protein 0.0023 0.0087 0.0306
Echinococcus multilocularis GRB2 associated binding protein 3 0.002 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0037
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0113 0.0806
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0333
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0254 0.0254
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0099
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2135 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0079 0.0112
Echinococcus multilocularis beta 1 syntrophin 0.002 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.003 0.014 0.0207
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0099
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0492 1
Schistosoma mansoni wnt-5 0.0015 0.0031 0.0031
Echinococcus multilocularis muscleblind protein 0.0318 0.2178 0.2178
Echinococcus granulosus GPCR family 2 0.0016 0.0038 0.0038
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0596 0.0596
Brugia malayi GTP-ase activating protein for Arf containing protein 0.002 0.0071 0.0278
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0492 0.0492
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0596 1
Brugia malayi Importin beta-1 subunit 0.0029 0.0133 0.0551
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.002 0.0071 0.0099
Loa Loa (eye worm) RhoGEF domain-containing protein 0.002 0.0071 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0333
Trypanosoma cruzi NIMA-related kinase, putative 0.0023 0.0087 0.0383
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0333
Loa Loa (eye worm) hypothetical protein 0.0034 0.0166 0.0247
Echinococcus multilocularis actin binding protein anillin 0.002 0.0071 0.0071
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0079 0.0079
Entamoeba histolytica Ran family GTPase 0.0021 0.0079 0.015
Schistosoma mansoni intermediate filament proteins 0.0033 0.0158 0.0158
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Echinococcus granulosus GRB2 associated binding protein 3 0.002 0.0071 0.0071
Trypanosoma brucei protein kinase, putative 0.0023 0.0087 0.0383
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0254 0.0254
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0366 0.6136
Brugia malayi PH domain containing protein 0.002 0.0071 0.0278
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0021 0.0079 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0079 0.0314
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0079 0.5
Schistosoma mansoni oxysterol-binding protein 1 0.002 0.0071 0.0071
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0099
Loa Loa (eye worm) hypothetical protein 0.0095 0.0598 0.0923
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0099
Loa Loa (eye worm) hypothetical protein 0.0021 0.0079 0.0112
Onchocerca volvulus 0.0021 0.0079 0.0054
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.002 0.0071 0.0333
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0492 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0079 0.0111
Brugia malayi Muscleblind-like protein 0.0318 0.2178 0.9516
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0023 0.0087 0.0383
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0165
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0596 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0087 0.0306
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.002 0.0071 0.0071
Echinococcus granulosus axis inhibition protein axin 0.0095 0.0598 0.0598
Echinococcus granulosus tumor protein p63 0.0408 0.2815 0.2815
Echinococcus multilocularis regulator of G protein signaling 7 0.0095 0.0598 0.0598
Brugia malayi Pre-SET motif family protein 0.0206 0.1385 0.6041
Echinococcus granulosus Protein Wnt-5 0.0015 0.0031 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0333
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0023 0.0087 0.0383
Schistosoma mansoni centaurin alpha 0.002 0.0071 0.0071
Loa Loa (eye worm) Wnt2 protein 0.0015 0.0031 0.0037
Loa Loa (eye worm) hypothetical protein 0.006 0.035 0.0535
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0071 0.0333
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0079 0.0314
Schistosoma mansoni vav2 0.002 0.0071 0.0071
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0038 0.0047
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0021 0.0079 0.0112
Echinococcus multilocularis Ras associated and pleckstrin y 0.002 0.0071 0.0071
Echinococcus granulosus Pleckstrin y 0.002 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0099
Echinococcus multilocularis oxysterol binding protein 3 0.002 0.0071 0.0071
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.2124 0.3307
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0037
Echinococcus granulosus lamin 0.0033 0.0158 0.0158
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0079 0.0079
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0094 0.0442
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0099
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0079 0.0079
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0087 0.0306
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0023 0.0087 0.0383
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.1376 0.861
Loa Loa (eye worm) hypothetical protein 0.0015 0.0035 0.0042
Entamoeba histolytica protein kinase, putative 0.0023 0.0087 0.0306
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0079 0.0079
Entamoeba histolytica hypothetical protein 0.0023 0.0087 0.0306
Leishmania major importin beta-1 subunit, putative 0.0024 0.0094 0.0554
Echinococcus granulosus Pleckstrin y 0.002 0.0071 0.0071
Echinococcus multilocularis protein Wnt 1 0.0015 0.0031 0.0031
Brugia malayi hypothetical protein 0.0095 0.0598 0.2589
Trichomonas vaginalis centaurin alpha, putative 0.002 0.0071 0.0333
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.002 0.0071 0.0071
Trypanosoma cruzi Protein kinase B 0.0023 0.0087 0.0383
Brugia malayi Cadps2 protein 0.002 0.0071 0.0278
Echinococcus granulosus Rho GTPase activating protein 24 0.002 0.0071 0.0071
Echinococcus granulosus oxysterol binding protein 3 0.002 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0021 0.0079 0.0112
Trichomonas vaginalis hypothetical protein 0.002 0.0071 0.0333
Loa Loa (eye worm) wnt-4 protein 0.0015 0.0031 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0079 0.0112
Schistosoma mansoni regulator of G protein signaling 0.0095 0.0598 0.0598
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.002 0.0071 0.0333
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0113 0.0806
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0023 0.0087 0.0307
Trichomonas vaginalis centaurin/arf, putative 0.002 0.0071 0.0333
Brugia malayi Syntrophin-1 0.002 0.0071 0.0278
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0079 0.0054
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.002 0.0071 0.0333
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0079 0.0112
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0079 0.0079
Brugia malayi MAX-1A 0.002 0.0071 0.0278
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0023 0.0087 0.0383
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0051 0.019
Echinococcus granulosus Pleckstrin y 0.002 0.0071 0.0071
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.002 0.0071 0.0071
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0235 0.0235
Schistosoma mansoni importin beta-1 0.0029 0.0133 0.0133
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0079 0.015
Schistosoma mansoni goodpasture antigen-binding protein 0.002 0.0071 0.0071
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0087 0.0306
Brugia malayi GTP-ase activating protein for Arf containing protein 0.002 0.0071 0.0278
Plasmodium falciparum calcium-dependent protein kinase 7 0.0023 0.0087 0.0307
Echinococcus multilocularis oxysterol binding protein 1 0.002 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0099
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0051 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0318 0.0318
Trichomonas vaginalis alpha chimerin, putative 0.002 0.0071 0.0333
Brugia malayi intermediate filament protein 0.0033 0.0158 0.0659
Toxoplasma gondii hypothetical protein 0.0033 0.0158 0.1652
Schistosoma mansoni wnt related 0.0015 0.0031 0.0031
Brugia malayi Cytohesin 3 0.002 0.0071 0.0278
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0038 0.0038
Brugia malayi Zinc finger, C2H2 type family protein 0.0334 0.2288 1
Schistosoma mansoni dynamin 0.002 0.0071 0.0071
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.0087 0.0383
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Schistosoma mansoni hypothetical protein 0.002 0.0071 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0598 0.2802
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1376 0.6445
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2135 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0008 0.0008
Brugia malayi PXA domain containing protein 0.0095 0.0598 0.2589
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0079 0.0314
Echinococcus granulosus beta-adrenergic receptor kinase 0.0916 0.6407 0.6407
Brugia malayi PH domain containing protein 0.002 0.0071 0.0278
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0079 0.0079
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0492 0.7982
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0158 0.0235
Schistosoma mansoni wnt related 0.0015 0.0031 0.0031
Echinococcus granulosus importin subunit beta 1 0.0029 0.0133 0.0133
Schistosoma mansoni oxysterol-binding protein 1 0.002 0.0071 0.0071
Brugia malayi Wnt-4 protein precursor 0.0015 0.0031 0.0103
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0079 0.015
Schistosoma mansoni wnt related 0.0015 0.0031 0.0031
Brugia malayi TBC domain containing protein 0.002 0.0071 0.0278
Loa Loa (eye worm) cytohesin 3 0.002 0.0071 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0071 0.0099
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0318 0.0318
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0079 0.0314
Echinococcus multilocularis axis inhibition protein axin 0.0095 0.0598 0.0598
Loa Loa (eye worm) PH domain-containing protein 0.002 0.0071 0.0099
Brugia malayi PH domain containing protein 0.002 0.0071 0.0278
Schistosoma mansoni hypothetical protein 0.002 0.0071 0.0071
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Schistosoma mansoni cellular tumor antigen P53 0.006 0.035 0.035
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0596 1
Echinococcus multilocularis pdz domain containing protein 0.002 0.0071 0.0071
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.002 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0205 0.1376 0.1376
Echinococcus granulosus cytohesin 1 0.002 0.0071 0.0071
Schistosoma mansoni regulator of G protein signaling 0.0095 0.0598 0.0598
Trichomonas vaginalis AGC family protein kinase 0.0023 0.0087 0.0409
Trypanosoma brucei rac serine-threonine kinase, putative 0.0023 0.0087 0.0383
Echinococcus multilocularis DCC interacting protein 13 beta 0.002 0.0071 0.0071
Echinococcus multilocularis musashi 0.0033 0.0158 0.0158

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.6511 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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