Detailed information for compound 1452123

Basic information

Technical information
  • TDR Targets ID: 1452123
  • Name: N-[2-[3-[2-[(5-methyl-1,2-oxazol-3-yl)amino]- 2-oxoethyl]sulfanylindol-1-yl]ethyl]benzamide
  • MW: 434.511 | Formula: C23H22N4O3S
  • H donors: 2 H acceptors: 3 LogP: 3.5 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1noc(c1)C)CSc1cn(c2c1cccc2)CCNC(=O)c1ccccc1
  • InChi: 1S/C23H22N4O3S/c1-16-13-21(26-30-16)25-22(28)15-31-20-14-27(19-10-6-5-9-18(19)20)12-11-24-23(29)17-7-3-2-4-8-17/h2-10,13-14H,11-12,15H2,1H3,(H,24,29)(H,25,26,28)
  • InChiKey: GKVMLTINPUPYKT-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[2-[3-[2-[(5-methylisoxazol-3-yl)amino]-2-oxo-ethyl]sulfanylindol-1-yl]ethyl]benzamide
  • N-[2-[3-[[2-[(5-methyl-3-isoxazolyl)amino]-2-oxoethyl]thio]-1-indolyl]ethyl]benzamide
  • N-[2-[3-[[2-keto-2-[(5-methylisoxazol-3-yl)amino]ethyl]thio]indol-1-yl]ethyl]benzamide
  • N-[2-[3-[2-[(5-methyl-1,2-oxazol-3-yl)amino]-2-oxo-ethyl]sulfanylindol-1-yl]ethyl]benzamide
  • MLS000100993
  • SMR000017510
  • Oprea1_102572

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphatidylinositol-5-phosphate 4-kinase, type II, alpha Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Trypanosoma brucei phosphoglycerate kinase Starlite/ChEMBL No references
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references
Trypanosoma brucei gambiense phosphoglycerate kinase, putative No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma congolense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum Phosphoglycerate kinase (EC 2.7.2.3), related Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Onchocerca volvulus Get druggable targets OG5_131617 All targets in OG5_131617
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii phosphoglycerate kinase PGKII Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Pip kinase protein 2 Get druggable targets OG5_131617 All targets in OG5_131617
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) pip kinase 2 Get druggable targets OG5_131617 All targets in OG5_131617
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
Entamoeba histolytica phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium falciparum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Giardia lamblia Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 Get druggable targets OG5_131617 All targets in OG5_131617
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K00889 1-phosphatidylinositol-4-phosphate 5-kinase [EC2.7.1.68], putative Get druggable targets OG5_131617 All targets in OG5_131617
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Treponema pallidum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Chlamydia trachomatis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis PGKC, phosphoglycerate kinase C Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii phosphoglycerate kinase PGKI Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II Get druggable targets OG5_131617 All targets in OG5_131617
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania infantum phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium berghei phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131617 All targets in OG5_131617
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 Get druggable targets OG5_131617 All targets in OG5_131617
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium hominis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II Get druggable targets OG5_131617 All targets in OG5_131617
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative Get druggable targets OG5_126776 All targets in OG5_126776
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium yoelii phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 406 aa 341 aa 32.0 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.00000000028822 0.00000000029463
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0029 0.0479 0.0711
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.3268 0.3341
Schistosoma mansoni hypothetical protein 0.0032 0.0569 0.0569
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.2549 0.4239
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1842 0.1722
Echinococcus multilocularis dna polymerase eta 0.0095 0.2507 0.2507
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1033 0.1056
Trypanosoma brucei chrX additional, unordered contigs 0.002 0.0189 0.0218
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0016 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0052 0.1182 0.1209
Loa Loa (eye worm) hypothetical protein 0.0166 0.4722 0.4827
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.046 0.0282
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0044 0.0929 0.0771
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.1141 0.1839
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0236 0.0048
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0206 0.593 0.6434
Echinococcus multilocularis geminin 0.0337 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0236 0.0241
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0515 0.0869
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.593 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.046 0.0282
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0515 0.0869
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0569 0.0569
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1842 0.1842
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.2549 0.4239
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.2549 0.4239
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.00000000028822 0.00000000029463
Onchocerca volvulus 0.0196 0.5644 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.00000000028822 0.00000000029463
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0037 0.0719 0.1213
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0273 0.0279
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.1556 0.1523
Schistosoma mansoni hypothetical protein 0.0032 0.0569 0.0569
Echinococcus granulosus phosphoglycerate kinase 1 0.0206 0.593 0.593
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0792 0.1336
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0273 0.0461
Echinococcus multilocularis ornithine aminotransferase 0.0044 0.0929 0.0929
Leishmania major DNA polymerase kappa, putative 0.002 0.0189 0.0218
Giardia lamblia Sgs1 DNA helicase, putative 0.0023 0.0273 0.0361
Schistosoma mansoni hypothetical protein 0.0032 0.0569 0.0569
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.593 0.593
Onchocerca volvulus 0.0037 0.0718 0.1271
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.00000000028822 0.00000000029463
Schistosoma mansoni DNA helicase recq1 0.0023 0.0273 0.0273
Brugia malayi hypothetical protein 0.002 0.0182 0.0186
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.00000000028822 0.00000000029463
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.1187 0.1919
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0061 0.0103
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.046 0.0282
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.2549 0.4239
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.2549 0.4239
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.1556 0.1591
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0515 0.0869
Trypanosoma brucei unspecified product 0.0088 0.2303 0.3819
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0515 0.0774
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0308 0.9106 1
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0044 0.0929 0.0543
Echinococcus granulosus bloom syndrome protein 0.0055 0.1267 0.1267
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0028 0.0436 0.0735
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0569 0.0581
Mycobacterium ulcerans phosphoglycerate kinase 0.0206 0.593 0.5984
Trypanosoma brucei unspecified product 0.0044 0.0941 0.1499
Brugia malayi Pip kinase protein 1 0.0016 0.0061 0.0063
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.593 1
Brugia malayi Associated with TFs and helicases family protein 0.0014 0.00000000028822 0.00000000029463
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.593 0.6062
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0064 0.1556 0.1556
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0016 0.0061 0.0061
Mycobacterium ulcerans L-lysine aminotransferase 0.0044 0.0929 0.0771
Trypanosoma brucei DNA polymerase IV, putative 0.0088 0.2303 0.3819
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.3268 0.3341
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0029 0.0479 0.0711
Echinococcus granulosus chromobox protein 1 0.0084 0.2176 0.2176
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0044 0.0929 0.0819
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0037 0.0706 0.119
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.1187 0.1919
Trypanosoma cruzi DNA polymerase eta, putative 0.0095 0.2507 0.4168
Giardia lamblia Phosphoglycerate kinase 0.0206 0.593 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.046 0.0292
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0236 0.0041
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0189 0.0218
Brugia malayi CHD4 protein 0.0014 0.00000000028822 0.00000000029463
Echinococcus granulosus ornithine aminotransferase 0.0044 0.0929 0.0929
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0792 0.1336
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0016 0.0061 0.0103
Schistosoma mansoni hypothetical protein 0.0069 0.1723 0.1723
Loa Loa (eye worm) hypothetical protein 0.0037 0.0718 0.0733
Brugia malayi AMP-binding enzyme family protein 0.0029 0.046 0.047
Plasmodium vivax DNA repair protein REV1, putative 0.002 0.0189 0.0319
Echinococcus multilocularis chromobox protein 1 0.0084 0.2176 0.2176
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0308 0.9106 1
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 0.5644 0.5644
Loa Loa (eye worm) hypothetical protein 0.0032 0.0569 0.0581
Plasmodium vivax hypothetical protein, conserved 0.0014 0.00000000028822 0.00000000048606
Mycobacterium ulcerans glutaminase 0.033 0.9782 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1033 0.1056
Schistosoma mansoni chromobox protein 0.0084 0.2176 0.2176
Brugia malayi MH2 domain containing protein 0.0119 0.3268 0.3341
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0064 0.1556 0.1556
Trypanosoma brucei DNA polymerase kappa, putative 0.0072 0.1802 0.2967
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0061 0.0103
Trichomonas vaginalis DNA helicase recq, putative 0.0055 0.1267 0.1296
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.046 0.0282
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0821 0.084
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.046 0.0775
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0569 0.0581
Entamoeba histolytica phosphoglycerate kinase, putative 0.0206 0.593 1
Entamoeba histolytica phosphoinositide kinase, putative 0.0016 0.0061 0.0103
Schistosoma mansoni glutaminase 0.033 0.9782 0.9782
Echinococcus granulosus dna polymerase kappa 0.0096 0.2549 0.2549
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0016 0.0061 0.0103
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0236 0.0397
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.00000000028822 0.00000000028822
Echinococcus granulosus GPCR family 2 0.0032 0.0569 0.0569
Trichomonas vaginalis chromobox protein, putative 0.0084 0.2176 0.2224
Entamoeba histolytica recQ family helicase, putative 0.0029 0.0479 0.0807
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0016 0.0061 0.0103
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0014 0.00000000028822 0.00000000028822
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.2549 0.4239
Mycobacterium ulcerans hypothetical protein 0.0029 0.046 0.0282
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0014 0.00000000028822 0.00000000028822
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0096 0.2549 0.2606
Loa Loa (eye worm) hypothetical protein 0.0029 0.046 0.047
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0206 0.593 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.2549 0.4239
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.00000000028822 0.00000000029463
Loa Loa (eye worm) glutaminase 0.033 0.9782 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.00000000028822 0.00000000028822
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.046 0.0678
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0048 0.1062 0.1791
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0016 0.0061 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.2549 0.4239
Onchocerca volvulus 0.0029 0.046 0.0814
Loa Loa (eye worm) hypothetical protein 0.0029 0.046 0.047
Plasmodium vivax ornithine aminotransferase, putative 0.0044 0.0929 0.1567
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.1907 0.3145
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1842 0.3034
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0189 0.0218
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0016 0.0061 0.0061
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.2718 0.2778
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1842 0.1842
Brugia malayi ImpB/MucB/SamB family protein 0.0095 0.2507 0.2563
Echinococcus granulosus dna polymerase eta 0.0095 0.2507 0.2507
Leishmania major DNA damage repair protein, putative 0.002 0.0189 0.0218
Trypanosoma brucei phosphoglycerate kinase, putative 0.0075 0.1907 0.3145
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0016 0.0061 0.0103
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0273 0.0273
Brugia malayi glutaminase DH11.1 0.033 0.9782 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.00000000028822 0.00000000028822
Echinococcus granulosus Aminotransferase class III 0.0044 0.0929 0.0929
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0821 0.084
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0273 0.0273
Schistosoma mansoni chromobox protein 0.0084 0.2176 0.2176
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0044 0.0929 0.0819
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0014 0.00000000028822 0.00000000029463
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.2549 0.4239
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0515 0.0774
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.1907 0.3145
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0016 0.0061 0.0063
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 0.5644 0.5644
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0569 0.0569
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.2176 0.2224
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0014 0.00000000028822 0.00000000048606
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0044 0.0929 0.0543
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0189 0.0319
Trypanosoma brucei unspecified product 0.0044 0.0941 0.1499
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0273 0.0273
Plasmodium falciparum ornithine aminotransferase 0.0044 0.0929 0.1567
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0061 0.0103
Brugia malayi polk-prov protein 0.0052 0.1182 0.1209
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.2549 0.4239
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.00000000028822 0.00000000029463
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.00000000028822 0.00000000048606
Schistosoma mansoni rotamase 0.004 0.0821 0.0821
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0569 0.0569
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.00000000028822 0.00000000029463
Mycobacterium ulcerans DNA polymerase IV 0.0096 0.2549 0.246
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0206 0.593 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.046 0.0775
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0044 0.0929 0.095
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0236 0.0397
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.046 0.0775
Loa Loa (eye worm) hypothetical protein 0.0095 0.2507 0.2563
Echinococcus multilocularis phosphoglycerate kinase 1 0.0206 0.593 0.593
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.1907 0.3145
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.046 0.0282
Echinococcus granulosus chromobox protein 1 0.0084 0.2176 0.2176
Treponema pallidum phosphoglycerate kinase 0.0206 0.593 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0607 0.062
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1842 0.1722
Schistosoma mansoni phosphoglycerate kinase 0.0206 0.593 0.593
Loa Loa (eye worm) pip kinase 2 0.0196 0.5644 0.577
Loa Loa (eye worm) hypothetical protein 0.0023 0.0273 0.0279
Leishmania major DNA polymerase kappa, putative 0.0072 0.1802 0.2967
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.00000000028822 0.00000000029463
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.1033 0.183
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0044 0.0929 0.0929
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0016 0.0061 0.0063
Trichomonas vaginalis chromobox protein, putative 0.0084 0.2176 0.2224
Leishmania major DNA polymerase eta, putative 0.0095 0.2507 0.4168
Loa Loa (eye worm) FYVE zinc finger family protein 0.0016 0.0061 0.0063
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0016 0.0061 0.0061
Brugia malayi AMP-binding enzyme family protein 0.0029 0.046 0.047
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1842 0.1842
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0044 0.0929 0.0771
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.00000000028822 0.00000000029463
Trichomonas vaginalis DNA polymerase eta, putative 0.0096 0.2549 0.2606
Schistosoma mansoni hypothetical protein 0.0032 0.0569 0.0569
Schistosoma mansoni hypothetical protein 0.0014 0.00000000028822 0.00000000028822
Trypanosoma brucei phosphoglycerate kinase 0.0075 0.1907 0.3145
Echinococcus multilocularis Chromo domain 0.0014 0.00000000028822 0.00000000028822
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0016 0.0061 0.0061
Leishmania major phosphoglycerate kinase B, cytosolic 0.0206 0.593 1
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.00000000028822 0.00000000029463
Leishmania major phosphoglycerate kinase C, glycosomal 0.0206 0.593 1
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0016 0.0061 0.0061
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0569 0.0581
Leishmania major DNA polymerase eta, putative 0.0051 0.1141 0.1839
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0029 0.0479 0.0711
Brugia malayi Phosphoglycerate kinase 0.0206 0.593 0.6062
Entamoeba histolytica hypothetical protein 0.0014 0.00000000028822 0.00000000048606
Plasmodium falciparum phosphoglycerate kinase 0.0206 0.593 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.2549 0.4239
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0206 0.593 1
Echinococcus multilocularis expressed protein 0.004 0.0821 0.0821
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1842 0.1842
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.00000000028822 0.00000000048606
Schistosoma mansoni terminal deoxycytidyl transferase 0.0064 0.1556 0.1556
Mycobacterium ulcerans hypothetical protein 0.0308 0.9106 0.9295
Echinococcus multilocularis GPCR, family 2 0.0032 0.0569 0.0569
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.2549 0.4239
Giardia lamblia DNA damage repair protein 0.002 0.0189 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.1182 0.191
Loa Loa (eye worm) hypothetical protein 0.0014 0.00000000028822 0.00000000029463
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.2718 0.2778
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.046 0.0678
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0016 0.0061 0.0063
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0308 0.9106 0.9308
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0075 0.1907 0.3145
Echinococcus granulosus Chromo domain 0.0014 0.00000000028822 0.00000000028822
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0075 0.1907 0.3145
Loa Loa (eye worm) glutaminase 2 0.033 0.9782 1
Schistosoma mansoni DNA polymerase eta 0.0095 0.2507 0.2507
Brugia malayi Heterochromatin protein 1 0.0084 0.2176 0.2224
Brugia malayi Phosphoglycerate kinase 0.0075 0.1907 0.195
Echinococcus multilocularis chromobox protein 1 0.0084 0.2176 0.2176
Schistosoma mansoni DNA helicase recq5 0.0023 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0069 0.1723 0.1761
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0072 0.1802 0.2967
Leishmania major hypothetical protein, conserved 0.003 0.0515 0.0774
Brugia malayi Pip kinase protein 2 0.0196 0.5644 0.577
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.046 0.0292
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.046 0.0678
Trypanosoma brucei DNA polymerase eta, putative 0.0095 0.2507 0.4168
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1842 0.1844
Trypanosoma brucei phosphoglycerate kinase 0.0206 0.593 1
Schistosoma mansoni hypothetical protein 0.0337 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.2549 0.4239
Loa Loa (eye worm) hypothetical protein 0.0021 0.0236 0.0241
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0016 0.0061 0.0061
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0792 0.1245
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0064 0.1556 0.1556
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.1143 0.2026
Echinococcus multilocularis bloom syndrome protein 0.0055 0.1267 0.1267
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0821 0.084
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0515 0.0774
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0014 0.00000000028822 0.00000000048606
Loa Loa (eye worm) hypothetical protein 0.003 0.0515 0.0527
Loa Loa (eye worm) hypothetical protein 0.0196 0.5644 0.577
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1842 0.3106
Echinococcus multilocularis dna polymerase kappa 0.0096 0.2549 0.2549
Plasmodium vivax phosphoglycerate kinase, putative 0.0206 0.593 1
Trichomonas vaginalis chromobox protein, putative 0.0051 0.1143 0.1169
Loa Loa (eye worm) hypothetical protein 0.0021 0.0236 0.0241
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.00000000028822 0.00000000029463
Mycobacterium ulcerans acetylornithine aminotransferase 0.0044 0.0929 0.0771
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0189 0.0218
Loa Loa (eye worm) hypothetical protein 0.0029 0.046 0.047
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0206 0.593 0.6327
Echinococcus multilocularis Aminotransferase class III 0.0044 0.0929 0.0929
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0569 0.0569
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0308 0.9106 0.9295
Loa Loa (eye worm) hypothetical protein 0.0021 0.0236 0.0241
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.046 0.0282
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.1723 0.1761
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0044 0.0929 0.0771
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0273 0.0279
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0273 0.0279
Mycobacterium tuberculosis Probable aminotransferase 0.0308 0.9106 1
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0044 0.0929 0.0543
Schistosoma mansoni hypothetical protein 0.0337 1 1
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0044 0.0929 0.0819
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0189 0.0218
Chlamydia trachomatis phosphoglycerate kinase 0.0206 0.593 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0273 0.0273
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.2549 0.4239
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.1182 0.191
Brugia malayi chromobox protein homolog 3 0.0047 0.1033 0.1056
Brugia malayi hypothetical protein 0.003 0.0515 0.0527
Loa Loa (eye worm) hypothetical protein 0.0047 0.1033 0.1056
Loa Loa (eye worm) RecQ helicase 0.0055 0.1267 0.1296
Entamoeba histolytica deoxycytidyl transferase, putative 0.0064 0.1556 0.2624
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0189 0.0218
Trichomonas vaginalis glutaminase, putative 0.033 0.9782 1
Trichomonas vaginalis chromobox protein, putative 0.0051 0.1143 0.1169
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.00000000028822 0.00000000028822
Trichomonas vaginalis rotamase, putative 0.004 0.0821 0.084
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 0.5644 0.5644
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1842 0.1722
Loa Loa (eye worm) hypothetical protein 0.0206 0.593 0.6062
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0075 0.1907 0.3145
Plasmodium falciparum DNA repair protein REV1, putative 0.002 0.0189 0.0319
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 0.5644 0.5644
Giardia lamblia DINP protein human, muc B family 0.0072 0.1802 0.2967
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0051 0.1141 0.1923
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0044 0.0929 0.0819
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0792 0.1245
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0044 0.0929 0.0771
Loa Loa (eye worm) hypothetical protein 0.0102 0.2718 0.2778
Trichomonas vaginalis DNA helicase recq1, putative 0.0055 0.1267 0.1296
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.2718 0.2778
Echinococcus granulosus expressed protein 0.004 0.0821 0.0821
Brugia malayi Bloom's syndrome protein homolog 0.0055 0.1267 0.1296
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0206 0.593 0.6062
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0016 0.0061 0.0063
Schistosoma mansoni DNA polymerase IV / kappa 0.002 0.0189 0.0189
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0515 0.0869
Loa Loa (eye worm) hypothetical protein 0.0021 0.0236 0.0241
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0044 0.0929 0.1567
Mycobacterium ulcerans DNA polymerase IV 0.0096 0.2549 0.246
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.00000000028822 0.00000000048606
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.2549 0.4239
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.1187 0.1919
Trichomonas vaginalis rotamase, putative 0.0039 0.0792 0.081
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0792 0.1245
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0044 0.0929 0.1218
Schistosoma mansoni blooms syndrome DNA helicase 0.0043 0.0911 0.0911
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0607 0.062
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0792 0.1245
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0273 0.0461
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0273 0.0461
Brugia malayi AMP-binding enzyme family protein 0.0029 0.046 0.047
Loa Loa (eye worm) pip kinase 1 0.0016 0.0061 0.0063
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0206 0.593 1
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0189 0.0218
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.00000000028822 0.00000000029463
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0189 0.0218
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0072 0.1802 0.18
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0189 0.0218
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.046 0.0282
Echinococcus multilocularis ornithine aminotransferase 0.0044 0.0929 0.0929
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.00000000028822 0.00000000029463
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0479 0.0489
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0064 0.1556 0.1591

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.157 uM PubChem BioAssay. qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2643 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.4111 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.4368 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.691 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 12.1031 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds.. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Inhibitors of PI5P4K: Confirmation in Primary Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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