TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 493.502 | Formula: C22H22F3N5O3S
H donors: 1 H acceptors: 5 LogP: 0.94 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: N[C@H](Cc1cc(F)c(cc1F)F)CC(=O)N1CCn2c(C1)c(nn2)c1ccc(cc1)S(=O)(=O)C
InChi: 1S/C22H22F3N5O3S/c1-34(32,33)16-4-2-13(3-5-16)22-20-12-29(6-7-30(20)28-27-22)21(31)10-15(26)8-14-9-18(24)19(25)11-17(14)23/h2-5,9,11,15H,6-8,10,12,26H2,1H3/t15-/m1/s1
InChiKey: QXTFVDWIAWZYFH-OAHLLOKOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0062	0.0062	0.0375
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0062	0.0402
Brugia malayi	PH domain containing protein	0.0062	0.0062	0.0058
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0073	0.009	0.0103
Entamoeba histolytica	protein kinase, putative	0.0078	0.0103	0.0637
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0078	0.0103	0.0664
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0062	0.0062	0.0375
Echinococcus granulosus	pleckstrin y domain containing family A	0.0062	0.0062	0.0069
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Brugia malayi	Uncoordinated protein 104	0.0062	0.0062	0.0058
Brugia malayi	MAX-1A	0.0062	0.0062	0.0058
Loa Loa (eye worm)	cytohesin 3	0.0062	0.0062	0.0058
Giardia lamblia	Aurora kinase	0.0073	0.009	1
Plasmodium falciparum	oxysterol-binding protein, putative	0.0062	0.0062	0.5883
Onchocerca volvulus	outspread protein homolog	0.0062	0.0062	0.0407
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Schistosoma mansoni	myotubularin-related protein	0.0062	0.0062	0.0058
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0062	0.0062	0.0069
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0055	0.0045	0.4117
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Echinococcus granulosus	aurora kinase A	0.0073	0.009	0.0103
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0673	0.1548	0.1544
Trichomonas vaginalis	alpha chimerin, putative	0.0062	0.0062	0.0402
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0062	0.0062	0.0375
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0062	0.0062	0.0069
Echinococcus granulosus	Oxysterol binding protein 11	0.0062	0.0062	0.0069
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0062	0.0062	0.0069
Entamoeba histolytica	protein kinase domain containing protein	0.0073	0.009	0.0556
Echinococcus multilocularis	Oxysterol binding protein 11	0.0062	0.0062	0.0069
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0062	0.0062	0.0069
Trichomonas vaginalis	protein transport protein sec7, putative	0.0062	0.0062	0.0402
Brugia malayi	hypothetical protein	0.0265	0.0557	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0195	0.019
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0073	0.009	0.8728
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0195	0.019
Brugia malayi	Sema domain containing protein	0.0265	0.0557	0.0553
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Schistosoma mansoni	regulator of G protein signaling	0.0673	0.1548	0.1544
Onchocerca volvulus		0.0622	0.1424	1
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0195	0.1257
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0062	0.0062	0.0069
Trichomonas vaginalis	conserved hypothetical protein	0.0673	0.1548	1
Echinococcus multilocularis	regulator of G protein signaling 3	0.0673	0.1548	0.1846
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0062	0.0062	0.0069
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0062	0.0062	0.0375
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0078	0.0103	0.0637
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0078	0.0103	1
Toxoplasma gondii	hypothetical protein	0.0062	0.0062	0.5883
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0062	0.0058
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Brugia malayi	regulator of G-protein signaling rgs-7	0.0673	0.1548	0.1544
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0265	0.0557	0.0553
Trypanosoma cruzi	hypothetical protein	0.0062	0.0062	0.5883
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0062	0.0058
Brugia malayi	PH domain containing protein	0.0062	0.0062	0.0058
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0116	0.0195	0.1257
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trypanosoma cruzi	PH domain containing protein, putative	0.0062	0.0062	0.5883
Brugia malayi	Sema domain containing protein	0.0265	0.0557	0.0553
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0062	0.0062	0.0069
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0062	0.0062	0.0058
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0062	0.0402
Echinococcus granulosus	oxysterol binding protein 1	0.0062	0.0062	0.0069
Echinococcus granulosus	cytohesin 1	0.0062	0.0062	0.0069
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0062	0.0062	0.0058
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0038	0.0004	0.0028
Trypanosoma brucei	protein kinase, putative	0.0078	0.0103	1
Trypanosoma brucei	PH domain containing protein, putative	0.0062	0.0062	0.5883
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0062	0.0058
Leishmania major	protein kinase, putative	0.0073	0.009	0.8728
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0078	0.0103	1
Loa Loa (eye worm)	Plekhf2 protein	0.0062	0.0062	0.0058
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Schistosoma mansoni	hypothetical protein	0.0116	0.0195	0.019
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0062	0.0062	0.0407
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0062	0.0062	0.5883
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0004	0.0028
Loa Loa (eye worm)	PH domain-containing protein	0.0062	0.0062	0.0058
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Leishmania major	hypothetical protein, conserved	0.0062	0.0062	0.5883
Echinococcus multilocularis	regulator of G protein signaling 3	0.0673	0.1548	0.1846
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0078	0.0103	1
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Entamoeba histolytica	hypothetical protein	0.0062	0.0062	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0062	0.0058
Echinococcus multilocularis	expressed protein	0.0673	0.1548	0.1846
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0062	0.0062	0.0069
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0004	0.0028
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Onchocerca volvulus		0.0062	0.0062	0.0407
Trichomonas vaginalis	centaurin gamma, putative	0.0062	0.0062	0.0402
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Leishmania major	serine/threonine-protein kinase a, putative	0.0078	0.0103	1
Echinococcus granulosus	Pleckstrin y	0.0062	0.0062	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0062	0.0058
Brugia malayi	Protein kinase domain containing protein	0.0078	0.0103	0.0098
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Entamoeba histolytica	cell surface protease gp63, putative	0.0116	0.0195	0.1233
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Schistosoma mansoni	vesicular amine transporter	0.005	0.0033	0.0029
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trypanosoma cruzi	Protein kinase B	0.0078	0.0103	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0078	0.0103	1
Entamoeba histolytica	hypothetical protein	0.0062	0.0062	0.0375
Trichomonas vaginalis	AGC family protein kinase	0.0073	0.009	0.0583
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0673	0.1548	0.1544
Brugia malayi	Plekhf2 protein	0.0062	0.0062	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0062	0.0058
Leishmania major	folate/biopterin transporter, putative	0.0078	0.0103	1
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0062	0.0062	0.5883
Echinococcus multilocularis	myotubularin protein 13	0.0062	0.0062	0.0069
Schistosoma mansoni	protein kinase	0.0073	0.009	0.0086
Schistosoma mansoni	zinc finger protein	0.0062	0.0062	0.0058
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0038	0.0004	0.0028
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0052	0.0039	0.0034
Brugia malayi	Dynamin	0.0062	0.0062	0.0058
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0015	0.001
Trypanosoma cruzi	PH domain containing protein, putative	0.0062	0.0062	0.5883
Plasmodium vivax	hypothetical protein, conserved	0.0062	0.0062	0.5883
Echinococcus multilocularis	oxysterol binding protein 1	0.0062	0.0062	0.0069
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0116	0.0195	0.1257
Echinococcus granulosus	beta-adrenergic receptor kinase	0.3179	0.7645	0.9139
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0062	0.0062	0.5883
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0078	0.0103	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0038	0.0004	0.0028
Toxoplasma gondii	hypothetical protein	0.0062	0.0062	0.5883
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0062	0.0062	0.0069
Schistosoma mansoni	regulator of G protein signaling	0.0673	0.1548	0.1544
Schistosoma mansoni	hypothetical protein	0.0062	0.0062	0.0058
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0062	0.0402
Echinococcus granulosus	dynamin 1	0.0062	0.0062	0.0069
Toxoplasma gondii	Oxysterol-binding protein	0.0062	0.0062	0.5883
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0027	0.0023
Entamoeba histolytica	protein kinase, putative	0.0078	0.0103	0.0637
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0062	0.0062	0.0058
Echinococcus granulosus	axis inhibition protein axin	0.0673	0.1548	0.1846
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0062	0.0058
Trichomonas vaginalis	conserved hypothetical protein	0.0673	0.1548	1
Onchocerca volvulus		0.0062	0.0062	0.0407
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0078	0.0103	1
Echinococcus multilocularis	regulator of G protein signaling 7	0.0673	0.1548	0.1846
Brugia malayi	Oxysterol binding protein	0.0062	0.0062	0.0058
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Brugia malayi	probable spectrin beta chain	0.0062	0.0062	0.0058
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0085	0.0119	0.0115
Entamoeba histolytica	protein kinase, putative	0.0073	0.009	0.0556
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0062	0.0402
Brugia malayi	A-kinase anchor protein 10, precursor	0.0673	0.1548	0.1544
Loa Loa (eye worm)	AUR protein kinase	0.0073	0.009	0.0086
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0055	0.0045	0.4117
Schistosoma mansoni	hypothetical protein	0.0357	0.0779	0.0775
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trichomonas vaginalis	centaurin/arf, putative	0.0062	0.0062	0.0402
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0673	0.1548	1
Entamoeba histolytica	protein kinase, putative	0.0078	0.0103	0.0637
Echinococcus granulosus	neuroglian	0.0047	0.0027	0.0027
Brugia malayi	PH domain containing protein	0.0062	0.0062	0.0058
Entamoeba histolytica	hypothetical protein	0.0116	0.0195	0.1233
Echinococcus multilocularis	semaphorin 5B	0.0265	0.0557	0.0661
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0085	0.0119	0.0115
Echinococcus multilocularis	dynamin 1	0.0062	0.0062	0.0069
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0062	0.0062	0.0375
Trichomonas vaginalis	conserved hypothetical protein	0.0673	0.1548	1
Entamoeba histolytica	hypothetical protein	0.0673	0.1548	1
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Schistosoma mansoni	growth factor receptor-bound protein	0.0062	0.0062	0.0058
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0195	0.1257
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0004	0.0028
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0062	0.0058
Echinococcus granulosus	defective proboscis extension response	0.0047	0.0027	0.0027
Brugia malayi	PH domain containing protein	0.0062	0.0062	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0265	0.0557	0.0553
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0073	0.009	0.8728
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0015	0.001
Trichomonas vaginalis	centaurin alpha, putative	0.0062	0.0062	0.0402
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0062	0.0402
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.3179	0.7645	0.7644
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0078	0.0103	1
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0078	0.0103	0.0664
Schistosoma mansoni	z-protein (S1r protein)	0.0673	0.1548	0.1544
Schistosoma mansoni	protein kinase	0.0055	0.0045	0.004
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0062	0.0062	0.0058
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0062	0.0062	0.0375
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0062	0.0062	0.0375
Trypanosoma cruzi	hypothetical protein	0.0062	0.0062	0.5883
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0062	0.0058
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0062	0.0062	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0265	0.0557	0.0553
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Echinococcus granulosus	GRB2 associated binding protein 3	0.0062	0.0062	0.0069
Entamoeba histolytica	hypothetical protein	0.0062	0.0062	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0062	0.0058
Trypanosoma cruzi	hypothetical protein	0.0062	0.0062	0.5883
Echinococcus granulosus	G protein coupled receptor kinase 1	0.2507	0.6009	0.7183
Schistosoma mansoni	regulator of G protein signaling	0.0673	0.1548	0.1544
Trypanosoma brucei	protein kinase, putative	0.0055	0.0045	0.4117
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0078	0.0103	0.0637
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0055	0.0045	0.0048
Trichomonas vaginalis	conserved hypothetical protein	0.0673	0.1548	1
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.3475	0.8364	0.8364
Brugia malayi	hypothetical protein	0.0673	0.1548	0.1544
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0062	0.0062	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0062	0.0058
Loa Loa (eye worm)	AUR protein kinase	0.0073	0.009	0.0086
Echinococcus multilocularis	Pleckstrin y	0.0062	0.0062	0.0069
Schistosoma mansoni	axis inhibition protein axin	0.0673	0.1548	0.1544
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0673	0.1548	0.1846
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0062	0.0062	0.0407
Echinococcus granulosus	semaphorin 5B	0.0265	0.0557	0.0661
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0004	0.0028
Trypanosoma cruzi	hypothetical protein	0.0062	0.0062	0.5883
Onchocerca volvulus		0.0062	0.0062	0.0407
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0078	0.0103	0.0098
Schistosoma mansoni	dynamin	0.0062	0.0062	0.0058
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0062	0.0062	0.0375
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0062	0.0062	0.0375
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Leishmania major	protein kinase, putative	0.0055	0.0045	0.4117
Echinococcus multilocularis	neuroglian	0.0047	0.0027	0.0027
Trypanosoma cruzi	hypothetical protein	0.0062	0.0062	0.5883
Schistosoma mansoni	semaphorin 5-related	0.0265	0.0557	0.0553
Echinococcus multilocularis	cytohesin 1	0.0062	0.0062	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0195	0.019
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0055	0.0045	0.0048
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0039	0.0006	0.0002
Schistosoma mansoni	hypothetical protein	0.0265	0.0557	0.0553
Echinococcus multilocularis	pdz domain containing protein	0.0062	0.0062	0.0069
Brugia malayi	PXA domain containing protein	0.0673	0.1548	0.1544
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0062	0.0402
Brugia malayi	PH domain containing protein	0.0062	0.0062	0.0058
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0062	0.0402
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0062	0.0058
Entamoeba histolytica	protein kinase domain containing protein	0.0154	0.0287	0.183
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0039	0.0034
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0062	0.0062	0.5883
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0062	0.0402
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0062	0.0402
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0062	0.0062	0.0375
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0116	0.0195	0.1257
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0073	0.009	0.0556
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0078	0.0103	1
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0004	0.0028
Entamoeba histolytica	hypothetical protein	0.0116	0.0195	0.1233
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0062	0.0402
Echinococcus granulosus	roundabout 2	0.0052	0.0039	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0229	0.0469	0.0465
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0062	0.0062	0.5883
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0038	0.0004	0.0028
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0078	0.0103	1
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Echinococcus granulosus	serine/threonine protein kinase	0.0078	0.0103	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0673	0.1548	0.1544
Entamoeba histolytica	hypothetical protein	0.0116	0.0195	0.1233
Schistosoma mansoni	ephrin receptor	0.0043	0.0016	0.0012
Echinococcus granulosus	Pleckstrin y	0.0062	0.0062	0.0069
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0195	0.1257
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Schistosoma mansoni	dynamin	0.0062	0.0062	0.0058
Schistosoma mansoni	zinc finger protein	0.0062	0.0062	0.0058
Entamoeba histolytica	hypothetical protein	0.0062	0.0062	0.0375
Schistosoma mansoni	axis inhibition protein axin	0.0673	0.1548	0.1544
Plasmodium falciparum	protein kinase, putative	0.0055	0.0045	0.4117
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0062	0.0062	0.0058
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0078	0.0103	1
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0078	0.0103	1
Loa Loa (eye worm)	rho-GTPase-activating	0.0062	0.0062	0.0058
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Echinococcus granulosus	oxysterol binding protein 9	0.0062	0.0062	0.0069
Echinococcus granulosus	myotubularin protein 13	0.0062	0.0062	0.0069
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0039	0.0006	0.0002
Entamoeba histolytica	protein kinase, putative	0.0078	0.0103	0.0637
Loa Loa (eye worm)	hypothetical protein	0.0265	0.0557	0.0553
Schistosoma mansoni	protein kinase	0.0055	0.0045	0.004
Brugia malayi	Syntrophin-1	0.0062	0.0062	0.0058
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0265	0.0557	0.0553
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0062	0.0062	0.0069
Echinococcus multilocularis	aurora kinase A	0.0073	0.009	0.0103
Trypanosoma brucei	aurora B kinase	0.0073	0.009	0.8728
Schistosoma mansoni	serine/threonine-protein kinase	0.0078	0.0103	0.0098
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Schistosoma mansoni	serine/threonine-protein kinase	0.0078	0.0103	0.0098
Brugia malayi	PH domain containing protein	0.0062	0.0062	0.0058
Entamoeba histolytica	PH domain containing protein	0.0062	0.0062	0.0375
Entamoeba histolytica	hypothetical protein	0.0078	0.0103	0.0637
Schistosoma mansoni	goodpasture antigen-binding protein	0.0062	0.0062	0.0058
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0673	0.1548	0.1544
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0062	0.0062	0.0375
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0078	0.0103	1
Echinococcus granulosus	Regulator of G protein signaling 20	0.0673	0.1548	0.1846
Schistosoma mansoni	serine/threonine protein kinase	0.0073	0.009	0.0086
Entamoeba histolytica	hypothetical protein, conserved	0.0062	0.0062	0.0375
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0062	0.0062	0.0375
Loa Loa (eye worm)	AUR protein kinase	0.0073	0.009	0.0086
Trichomonas vaginalis	centaurin beta, putative	0.0062	0.0062	0.0402
Trypanosoma cruzi	PH domain containing protein, putative	0.0062	0.0062	0.5883
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Echinococcus multilocularis	Immunoglobulin	0.0047	0.0027	0.0027
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0039	0.0006	0.0002
Onchocerca volvulus		0.0062	0.0062	0.0407
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0038	0.0004	0.0028
Trichomonas vaginalis	AGC family protein kinase	0.0038	0.0004	0.0028
Entamoeba histolytica	tyrosin kinase, putative	0.0154	0.0287	0.183
Entamoeba histolytica	hypothetical protein	0.0078	0.0103	0.0637
Schistosoma mansoni	plexin	0.0357	0.0779	0.0775
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Onchocerca volvulus		0.0062	0.0062	0.0407
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0116	0.0195	0.1257
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0062	0.0402
Echinococcus granulosus	exocyst complex component 2	0.0116	0.0195	0.0228
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0043	0.0016	0.0014
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0073	0.009	0.0556
Trichomonas vaginalis	AGC family protein kinase	0.0073	0.009	0.0583
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Echinococcus multilocularis	oxysterol binding protein 3	0.0062	0.0062	0.0069
Leishmania major	protein kinase, putative	0.0078	0.0103	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0078	0.0103	0.0637
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Entamoeba histolytica	protein kinase, putative	0.0078	0.0103	0.0637
Brugia malayi	PH domain containing protein	0.0062	0.0062	0.0058
Loa Loa (eye worm)	sema domain-containing protein	0.0265	0.0557	0.0553
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0078	0.0103	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0062	0.0058
Trichomonas vaginalis	kinesin light chain, putative	0.0062	0.0062	0.0402
Schistosoma mansoni	hypothetical protein	0.0116	0.0195	0.019
Trichomonas vaginalis	hypothetical protein	0.0062	0.0062	0.0402
Toxoplasma gondii	protein kinase domain-containing protein	0.0078	0.0103	1
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0062	0.0062	0.5883
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0195	0.1257
Brugia malayi	PXA domain containing protein	0.0673	0.1548	0.1544
Loa Loa (eye worm)	TK/ALK protein kinase	0.0298	0.0637	0.0633
Echinococcus multilocularis	axis inhibition protein axin	0.0673	0.1548	0.1846
Brugia malayi	Protein kinase domain containing protein	0.0298	0.0637	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0062	0.0058
Loa Loa (eye worm)	RGS-3 protein	0.0673	0.1548	0.1544
Brugia malayi	Plexin repeat family protein	0.0622	0.1424	0.142
Schistosoma mansoni	hypothetical protein	0.0062	0.0062	0.0058
Trichomonas vaginalis	centaurin/arf, putative	0.0062	0.0062	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0062	0.0058
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.2507	0.6009	0.7183
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0039	0.0034
Echinococcus granulosus	Rho GTPase activating protein 24	0.0062	0.0062	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0027	0.0023
Trypanosoma cruzi	hypothetical protein	0.0062	0.0062	0.5883
Plasmodium vivax	PH domain containing protein	0.0062	0.0062	0.5883
Schistosoma mansoni	nephrin	0.0052	0.0039	0.0034
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0062	0.0402
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0078	0.0103	1
Trichomonas vaginalis	conserved hypothetical protein	0.0673	0.1548	1
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Entamoeba histolytica	hypothetical protein	0.0673	0.1548	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0038	0.0004	0.0028
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0078	0.0103	0.0637
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0027	0.0023
Brugia malayi	TBC domain containing protein	0.0062	0.0062	0.0058
Brugia malayi	plexin A	0.0738	0.1707	0.1703
Leishmania major	protein kinase, putative	0.0078	0.0103	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0055	0.0045	0.4117
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0047	0.0027	0.0023
Echinococcus multilocularis	roundabout 2	0.0052	0.0039	0.0041
Entamoeba histolytica	PH domain containing protein	0.0062	0.0062	0.0375
Onchocerca volvulus		0.0062	0.0062	0.0407
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.3475	0.8364	0.8364
Brugia malayi	Pleckstrin Homology Domain	0.0062	0.0062	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0357	0.0779	0.0775
Toxoplasma gondii	AtPH1 family protein	0.0062	0.0062	0.5883
Trichomonas vaginalis	STE family protein kinase	0.0038	0.0004	0.0028
Schistosoma mansoni	oxysterol-binding protein 1	0.0062	0.0062	0.0058
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0062	0.0062	0.0069
Toxoplasma gondii	aurora kinase	0.0073	0.009	0.8728
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0062	0.0062	0.0069
Brugia malayi	Oxysterol-binding protein	0.0062	0.0062	0.0058
Echinococcus multilocularis	Immunoglobulin	0.0047	0.0027	0.0027
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Schistosoma mansoni	vav2	0.0062	0.0062	0.0058
Loa Loa (eye worm)	oxysterol binding protein	0.0062	0.0062	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0195	0.019
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0062	0.0058
Brugia malayi	regulator of G-protein signaling egl-10	0.0673	0.1548	0.1544
Echinococcus granulosus	axis inhibition protein axin	0.0673	0.1548	0.1846
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0062	0.0062	0.0058
Schistosoma mansoni	regulator of G protein signaling	0.0673	0.1548	0.1544
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0673	0.1548	1
Entamoeba histolytica	protein kinase domain containing protein	0.0055	0.0045	0.0262
Schistosoma mansoni	syntrophin	0.0062	0.0062	0.0058
Echinococcus granulosus	DCC interacting protein 13 beta	0.0062	0.0062	0.0069
Echinococcus multilocularis	oxysterol binding protein 9	0.0062	0.0062	0.0069
Brugia malayi	hypothetical protein	0.0265	0.0557	0.0553
Schistosoma mansoni	hypothetical protein	0.0062	0.0062	0.0058
Brugia malayi	Probable exocyst complex component Sec5	0.0116	0.0195	0.019
Onchocerca volvulus		0.0062	0.0062	0.0407
Entamoeba histolytica	hypothetical protein	0.0673	0.1548	1
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0062	0.0062	0.5883
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Schistosoma mansoni	protein kinase	0.0055	0.0045	0.004
Brugia malayi	Variant SH3 domain containing protein	0.0062	0.0062	0.0058
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0673	0.1548	0.1846
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0062	0.0062	0.5883
Schistosoma mansoni	serine/threonine protein kinase	0.3179	0.7645	0.7644
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0062	0.0062	0.0375
Brugia malayi	PH domain containing protein	0.0062	0.0062	0.0058
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.3475	0.8364	0.8364
Brugia malayi	serine/threonine-protein kinase 6	0.0073	0.009	0.0086
Brugia malayi	DNA-binding protein LAG-1	0.0116	0.0195	0.019
Schistosoma mansoni	hypothetical protein	0.0265	0.0557	0.0553
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0062	0.0062	0.0402
Trypanosoma cruzi	hypothetical protein	0.0062	0.0062	0.5883
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0078	0.0103	0.0637
Schistosoma mansoni	centaurin alpha	0.0062	0.0062	0.0058
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Echinococcus multilocularis	Pleckstrin y	0.0062	0.0062	0.0069
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0062	0.0402
Entamoeba histolytica	protein kinase, putative	0.0078	0.0103	0.0637
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0078	0.0103	0.0637
Trichomonas vaginalis	AGC family protein kinase	0.0073	0.009	0.0583
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Brugia malayi	Variant SH3 domain containing protein	0.0062	0.0062	0.0058
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0062	0.0402
Echinococcus multilocularis	regulator of G protein signaling 7	0.0673	0.1548	0.1846
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0062	0.0402
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0062	0.0062	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0673	0.1548	0.1544
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0055	0.0045	0.4117
Entamoeba histolytica	PH domain containing protein	0.0062	0.0062	0.0375
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0047	0.0027	0.0023
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0078	0.0103	1
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Echinococcus multilocularis	regulator of G protein signaling	0.0673	0.1548	0.1846
Echinococcus granulosus	regulator of G protein signaling 7	0.0673	0.1548	0.1846
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0062	0.0062	0.0069
Echinococcus multilocularis	actin binding protein anillin	0.0062	0.0062	0.0069
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0043	0.0016	0.0014
Brugia malayi	hypothetical protein	0.0052	0.0039	0.0034
Trypanosoma cruzi	NIMA-related kinase, putative	0.0078	0.0103	1
Echinococcus granulosus	activin receptor type	0.0055	0.0045	0.0048
Echinococcus granulosus	plexin a4	0.0738	0.1707	0.2036
Schistosoma mansoni	goodpasture antigen-binding protein	0.0062	0.0062	0.0058
Onchocerca volvulus	Putative zinc finger protein	0.0062	0.0062	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0062	0.0058
Trichomonas vaginalis	TK family protein kinase	0.0038	0.0004	0.0028
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0062	0.0062	0.0402
Onchocerca volvulus		0.0265	0.0557	0.3891
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0195	0.1257
Echinococcus granulosus	regulator of G protein signaling 3	0.0673	0.1548	0.1846
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0062	0.0062	0.0402
Brugia malayi	Fibronectin type III domain containing protein	0.0052	0.0039	0.0034
Echinococcus multilocularis	plexin a4	0.0738	0.1707	0.2036
Brugia malayi	Cytohesin 3	0.0062	0.0062	0.0058
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0062	0.0062	0.0375
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0062	0.0062	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0673	0.1548	0.1544
Echinococcus multilocularis	exocyst complex component 2	0.0116	0.0195	0.0228
Brugia malayi	serine/threonine kinase 12	0.0073	0.009	0.0086
Loa Loa (eye worm)	plexin A	0.0738	0.1707	0.1703
Schistosoma mansoni	hypothetical protein	0.0062	0.0062	0.0058
Trichomonas vaginalis	AGC family protein kinase	0.0073	0.009	0.0583
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0027	0.0023
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0062	0.0062	0.0069
Plasmodium falciparum	PH domain-containing protein, putative	0.0062	0.0062	0.5883
Brugia malayi	hypothetical protein	0.0062	0.0062	0.0058
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.3475	0.8364	1
Schistosoma mansoni	rho gtpase activating protein	0.0062	0.0062	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0673	0.1548	0.1544
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0062	0.0402
Leishmania major	hypothetical protein, conserved	0.0062	0.0062	0.5883
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0004	0.0028
Echinococcus granulosus	regulator of G protein signaling 3	0.0673	0.1548	0.1846
Loa Loa (eye worm)	uncoordinated protein 104	0.0062	0.0062	0.0058
Trichomonas vaginalis	protein transport protein sec7, putative	0.0062	0.0062	0.0402
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0062	0.0062	0.0069
Loa Loa (eye worm)	PXA domain-containing protein	0.0673	0.1548	0.1544
Echinococcus granulosus	Immunoglobulin	0.0047	0.0027	0.0027
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Schistosoma mansoni	hypothetical protein	0.0062	0.0062	0.0058
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0062	0.0062	0.0069
Brugia malayi	hypothetical protein	0.0673	0.1548	0.1544
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0062	0.0062	0.0402
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0062	0.0062	0.5883
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0673	0.1548	0.1544
Brugia malayi	Cadps2 protein	0.0062	0.0062	0.0058
Entamoeba histolytica	hypothetical protein	0.0062	0.0062	0.0375
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Brugia malayi	IPT/TIG domain containing protein	0.0116	0.0195	0.019
Loa Loa (eye worm)	sema domain-containing protein	0.0265	0.0557	0.0553
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0116	0.0195	0.1257
Loa Loa (eye worm)	hypothetical protein	0.0265	0.0557	0.0553
Echinococcus granulosus	pdz domain containing protein	0.0062	0.0062	0.0069
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0062	0.0062	0.0069
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0062	0.0062	0.0069
Onchocerca volvulus	Protein melted homolog	0.0062	0.0062	0.0407
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0062	0.0062	0.0058
Echinococcus granulosus	Pleckstrin y	0.0062	0.0062	0.0069
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Echinococcus granulosus	beta 1 syntrophin	0.0062	0.0062	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0062	0.0058
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0073	0.009	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0027	0.0023
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0047	0.0027	0.0027
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0047	0.0027	0.0027
Trichomonas vaginalis	CAMK family protein kinase	0.0038	0.0004	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0039	0.0034
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0062	0.0402
Echinococcus multilocularis	axis inhibition protein axin	0.0673	0.1548	0.1846
Schistosoma mansoni	cell adhesion molecule	0.0052	0.0039	0.0034
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Echinococcus multilocularis	beta adrenergic receptor kinase	0.3179	0.7645	0.9139
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0039	0.0006	0.0002
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0062	0.0062	0.0402
Entamoeba histolytica	protein kinase , putative	0.0073	0.009	0.0556
Echinococcus multilocularis	Pleckstrin y	0.0062	0.0062	0.0069
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0078	0.0103	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0055	0.0045	0.0048
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0195	0.1257
Brugia malayi	Dynamin	0.0062	0.0062	0.0058
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0078	0.0103	1
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Entamoeba histolytica	protein kinase, putative	0.0073	0.009	0.0556
Echinococcus granulosus	calcium dependent secretion activator 1	0.0062	0.0062	0.0069
Trypanosoma cruzi	NIMA-related kinase, putative	0.0078	0.0103	1
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0062	0.0062	0.0069
Loa Loa (eye worm)	syntrophin-1	0.0062	0.0062	0.0058
Echinococcus granulosus	twitchin	0.0064	0.0067	0.0075
Echinococcus multilocularis	transcription factor collier	0.0116	0.0195	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0062	0.0058
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0673	0.1548	0.1846
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0062	0.0062	0.5883
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Echinococcus granulosus	regulator of G protein signaling 7	0.0673	0.1548	0.1846
Schistosoma mansoni	oxysterol-binding protein 1	0.0062	0.0062	0.0058
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.3475	0.8364	1
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Echinococcus granulosus	oxysterol binding protein 3	0.0062	0.0062	0.0069
Trypanosoma cruzi	PH domain containing protein, putative	0.0062	0.0062	0.5883
Entamoeba histolytica	protein kinase, putative	0.0078	0.0103	0.0637
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0062	0.0062	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0622	0.1424	0.142
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0062	0.0062	0.0069
Entamoeba histolytica	hypothetical protein	0.0116	0.0195	0.1233
Schistosoma mansoni	regulator of G protein signaling	0.0673	0.1548	0.1544
Trichomonas vaginalis	conserved hypothetical protein	0.0116	0.0195	0.1257
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0062	0.0058
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0004	0.0028
Schistosoma mansoni	fibrocystin l	0.0116	0.0195	0.019
Echinococcus multilocularis	activin receptor type	0.0055	0.0045	0.0048
Echinococcus multilocularis	beta 1 syntrophin	0.0062	0.0062	0.0069
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0673	0.1548	0.1544
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0062	0.0062	0.0069
Brugia malayi	serine/threonine protein kinase 6	0.0073	0.009	0.0086
Echinococcus multilocularis	rac serine:threonine kinase	0.0078	0.0103	0.0118
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.0004	0.0028
Schistosoma mansoni	plexin	0.0622	0.1424	0.142
Entamoeba histolytica	p21-activated kinase	0.0078	0.0103	0.0637
Brugia malayi	PH domain containing protein	0.0062	0.0062	0.0058
Echinococcus multilocularis	hypothetical protein	0.0265	0.0557	0.0661
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0673	0.1548	0.1544
Schistosoma mansoni	serine/threonine protein kinase	0.3179	0.7645	0.7644
Echinococcus granulosus	semaphorin 1A	0.0265	0.0557	0.0661
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0062	0.0062	0.0058
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0078	0.0103	1
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0073	0.009	0.0556
Echinococcus granulosus	expressed protein	0.0673	0.1548	0.1846
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0673	0.1548	0.1544
Loa Loa (eye worm)	hypothetical protein	0.0673	0.1548	0.1544
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0027	0.0023
Trichomonas vaginalis	AGC family protein kinase	0.0078	0.0103	0.0664
Echinococcus granulosus	transcription factor collier	0.0116	0.0195	0.0228
Trypanosoma cruzi	aurora B kinase, putative	0.0073	0.009	0.8728
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0078	0.0103	1
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0062	0.0062	0.0375
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0062	0.0062	0.0058

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1739483

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1509297