TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 242.101 | Formula: C13H11BO2S
H donors: 1 H acceptors: 1 LogP: 3 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: OB1OCc2c1cc(cc2)Sc1ccccc1
InChi: 1S/C13H11BO2S/c15-14-13-8-12(7-6-10(13)9-16-14)17-11-4-2-1-3-5-11/h1-8,15H,9H2
InChiKey: ZMFMGJUEAIXARG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Enterobacter cloacae	Beta-lactamase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	exocyst complex component 2	0.0065	0.011	0.0127
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0044	0.0042	0.0045
Onchocerca volvulus		0.0044	0.0042	0.0032
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0044	0.0042	0.0045
Schistosoma mansoni	myotubularin-related protein	0.0044	0.0042	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0039	0.0039
Echinococcus multilocularis	pdz domain containing protein	0.0044	0.0042	0.0045
Trypanosoma cruzi	NIMA-related kinase, putative	0.0057	0.0083	0.6886
Toxoplasma gondii	ABC1 family protein	0.0043	0.0039	0.3019
Brugia malayi	PXA domain containing protein	0.0484	0.1531	0.1517
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0067	0.0119	0.0137
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0057	0.0083	0.6886
Trichomonas vaginalis	protein transport protein sec7, putative	0.0044	0.0042	0.0224
Schistosoma mansoni	axis inhibition protein axin	0.0484	0.1531	0.1527
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0042	0.0224
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0039	0.0034
Schistosoma mansoni	regulator of G protein signaling	0.0484	0.1531	0.1527
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Trypanosoma cruzi	PH domain containing protein, putative	0.0044	0.0042	0.33
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0044	0.0042	0.0247
Toxoplasma gondii	AtPH1 family protein	0.0044	0.0042	0.33
Entamoeba histolytica	protein kinase , putative	0.0067	0.0119	0.0748
Loa Loa (eye worm)	hypothetical protein	0.034	0.1043	0.1043
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Brugia malayi	PH domain containing protein	0.0044	0.0042	0.0026
Echinococcus granulosus	semaphorin 5B	0.0147	0.0391	0.0462
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0057	0.0083	0.6886
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0039	0.0039
Echinococcus multilocularis	rac serine:threonine kinase	0.0057	0.0083	0.0094
Brugia malayi	regulator of G-protein signaling rgs-7	0.0484	0.1531	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0042	0.0042
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0042	0.0224
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0057	0.0083	0.6886
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0391	0.0391
Echinococcus multilocularis	axis inhibition protein axin	0.0484	0.1531	0.1826
Loa Loa (eye worm)	hypothetical protein	0.0484	0.1531	0.1531
Brugia malayi	Plexin repeat family protein	0.034	0.1043	0.1029
Echinococcus granulosus	serine/threonine protein kinase	0.0057	0.0083	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0042	0.0042
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0057	0.0083	0.6886
Entamoeba histolytica	hypothetical protein	0.0065	0.011	0.0693
Echinococcus granulosus	oxysterol binding protein 9	0.0044	0.0042	0.0045
Onchocerca volvulus		0.0044	0.0042	0.0032
Leishmania major	protein kinase, putative	0.0057	0.0083	0.6886
Trypanosoma cruzi	hypothetical protein	0.0044	0.0042	0.33
Trichomonas vaginalis	centaurin/arf, putative	0.0044	0.0042	0.0224
Trichomonas vaginalis	conserved hypothetical protein	0.0484	0.1531	1
Entamoeba histolytica	hypothetical protein, conserved	0.0044	0.0042	0.0247
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0028	0.0023
Brugia malayi	Protein kinase domain containing protein	0.0269	0.0801	0.0786
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0044	0.0042	0.0045
Schistosoma mansoni	plexin	0.0193	0.0545	0.054
Schistosoma mansoni	plexin	0.034	0.1043	0.1039
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0057	0.0083	0.0515
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0044	0.0042	0.0224
Echinococcus granulosus	DCC interacting protein 13 beta	0.0044	0.0042	0.0045
Schistosoma mansoni	dynamin	0.0044	0.0042	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.011	0.0671
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0042	0.0042
Brugia malayi	Variant SH3 domain containing protein	0.0044	0.0042	0.0026
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0044	0.0042	0.0247
Trichomonas vaginalis	AGC family protein kinase	0.0067	0.0119	0.0727
Entamoeba histolytica	hypothetical protein	0.0065	0.011	0.0693
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0039	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0044	0.0042	0.0038
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Echinococcus granulosus	Oxysterol binding protein 11	0.0044	0.0042	0.0045
Trichomonas vaginalis	AGC family protein kinase	0.0067	0.0119	0.0727
Schistosoma mansoni	z-protein (S1r protein)	0.0484	0.1531	0.1527
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0039	0.0203
Brugia malayi	PXA domain containing protein	0.0484	0.1531	0.1517
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.011	0.0671
Echinococcus granulosus	twitchin	0.0043	0.0038	0.004
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0391	0.0391
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0039	0.3019
Entamoeba histolytica	hypothetical protein	0.0057	0.0083	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0391	0.0391
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0484	0.1531	0.1826
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Brugia malayi	PH domain containing protein	0.0044	0.0042	0.0026
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0484	0.1531	0.1527
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0042	0.0224
Schistosoma mansoni	hypothetical protein	0.0193	0.0545	0.054
Entamoeba histolytica	hypothetical protein	0.0044	0.0042	0.0247
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.2289	0.764	0.764
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0044	0.0042	0.0224
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0039	0.5
Onchocerca volvulus	Protein melted homolog	0.0044	0.0042	0.0032
Brugia malayi	hypothetical protein	0.0484	0.1531	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0218	0.0629	0.0629
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Schistosoma mansoni	hypothetical protein	0.0147	0.0391	0.0386
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.1805	0.6001	0.7176
Echinococcus granulosus	Regulator of G protein signaling 20	0.0484	0.1531	0.1826
Brugia malayi	beta-lactamase family protein	0.0043	0.0039	0.0023
Echinococcus granulosus	plexin a4	0.0405	0.1262	0.1504
Toxoplasma gondii	aurora kinase	0.0067	0.0119	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0039	0.0034
Plasmodium vivax	PH domain containing protein	0.0044	0.0042	0.0403
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0042	0.0224
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0057	0.0083	0.6886
Brugia malayi	PH domain containing protein	0.0044	0.0042	0.0026
Echinococcus multilocularis	myotubularin protein 13	0.0044	0.0042	0.0045
Entamoeba histolytica	hypothetical protein	0.0484	0.1531	1
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.011	0.0671
Loa Loa (eye worm)	plexin A	0.0405	0.1262	0.1262
Loa Loa (eye worm)	TK/ALK protein kinase	0.0269	0.0801	0.0801
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0057	0.0083	0.6886
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0044	0.0042	0.0247
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0484	0.1531	0.1826
Entamoeba histolytica	p21-activated kinase	0.0057	0.0083	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0042	0.0042
Echinococcus granulosus	transcription factor collier	0.0065	0.011	0.0127
Loa Loa (eye worm)	sema domain-containing protein	0.0147	0.0391	0.0391
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0044	0.0042	0.0224
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0044	0.0042	0.0038
Schistosoma mansoni	oxysterol-binding protein 1	0.0044	0.0042	0.0038
Trypanosoma cruzi	PH domain containing protein, putative	0.0044	0.0042	0.33
Trichomonas vaginalis	conserved hypothetical protein	0.0484	0.1531	1
Onchocerca volvulus		0.0147	0.0391	0.3499
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0044	0.0042	0.0045
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0039	0.0039
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0039	0.5
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0057	0.0083	0.6886
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.011	0.0671
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0484	0.1531	0.1527
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0039	0.5
Echinococcus multilocularis	axis inhibition protein axin	0.0484	0.1531	0.1826
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0044	0.0042	0.0032
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0037	0.0016	0.0014
Brugia malayi	Protein kinase domain containing protein	0.0057	0.0083	0.0067
Echinococcus granulosus	beta-adrenergic receptor kinase	0.2289	0.764	0.9137
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0039	0.3019
Entamoeba histolytica	hypothetical protein	0.0484	0.1531	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0042	0.0042
Trypanosoma cruzi	aurora B kinase, putative	0.0067	0.0119	1
Echinococcus multilocularis	semaphorin 5B	0.0147	0.0391	0.0462
Echinococcus multilocularis	oxysterol binding protein 1	0.0044	0.0042	0.0045
Schistosoma mansoni	hypothetical protein	0.0044	0.0042	0.0038
Plasmodium falciparum	oxysterol-binding protein, putative	0.0044	0.0042	0.33
Trypanosoma cruzi	PH domain containing protein, putative	0.0044	0.0042	0.33
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0039	0.5
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0057	0.0083	0.0083
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0044	0.0042	0.0403
Leishmania major	hypothetical protein, conserved	0.0044	0.0042	0.33
Entamoeba histolytica	protein kinase, putative	0.0057	0.0083	0.0515
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0484	0.1531	0.1527
Echinococcus multilocularis	aurora kinase A	0.0067	0.0119	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Plasmodium vivax	hypothetical protein, conserved	0.0044	0.0042	0.0403
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0044	0.0042	0.0247
Schistosoma mansoni	axis inhibition protein axin	0.0484	0.1531	0.1527
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0042	0.0042
Schistosoma mansoni	regulator of G protein signaling	0.0484	0.1531	0.1527
Brugia malayi	hypothetical protein	0.0484	0.1531	0.1517
Echinococcus granulosus	Pleckstrin y	0.0044	0.0042	0.0045
Echinococcus granulosus	semaphorin 1A	0.0147	0.0391	0.0462
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Entamoeba histolytica	PH domain containing protein	0.0044	0.0042	0.0247
Echinococcus granulosus	dynamin 1	0.0044	0.0042	0.0045
Loa Loa (eye worm)	RGS-3 protein	0.0484	0.1531	0.1531
Brugia malayi	regulator of G-protein signaling egl-10	0.0484	0.1531	0.1517
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0067	0.0119	1
Schistosoma mansoni	syntrophin	0.0044	0.0042	0.0038
Entamoeba histolytica	protein kinase, putative	0.0057	0.0083	0.0515
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0044	0.0042	0.0224
Brugia malayi	Probable exocyst complex component Sec5	0.0065	0.011	0.0094
Brugia malayi	serine/threonine-protein kinase 6	0.0067	0.0119	0.0103
Leishmania major	serine/threonine-protein kinase a, putative	0.0057	0.0083	0.6886
Trypanosoma cruzi	hypothetical protein	0.0044	0.0042	0.33
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0039	0.0041
Echinococcus multilocularis	cytohesin 1	0.0044	0.0042	0.0045
Schistosoma mansoni	hypothetical protein	0.0147	0.0391	0.0386
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0057	0.0083	0.6886
Schistosoma mansoni	regulator of G protein signaling	0.0484	0.1531	0.1527
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0042	0.0224
Trichomonas vaginalis	alpha chimerin, putative	0.0044	0.0042	0.0224
Schistosoma mansoni	hypothetical protein	0.0044	0.0042	0.0038
Echinococcus multilocularis	actin binding protein anillin	0.0044	0.0042	0.0045
Echinococcus granulosus	regulator of G protein signaling 7	0.0484	0.1531	0.1826
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0037	0.0016	0.0014
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.011	0.0671
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0044	0.0042	0.0247
Entamoeba histolytica	cell surface protease gp63, putative	0.0065	0.011	0.0693
Schistosoma mansoni	semaphorin 5-related	0.0147	0.0391	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0042	0.0042
Onchocerca volvulus		0.0044	0.0042	0.0032
Leishmania major	protein kinase, putative	0.0057	0.0083	0.6886
Schistosoma mansoni	goodpasture antigen-binding protein	0.0044	0.0042	0.0038
Echinococcus granulosus	axis inhibition protein axin	0.0484	0.1531	0.1826
Trichomonas vaginalis	AGC family protein kinase	0.0067	0.0119	0.0727
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Echinococcus granulosus	expressed protein	0.0484	0.1531	0.1826
Trichomonas vaginalis	centaurin alpha, putative	0.0044	0.0042	0.0224
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0044	0.0042	0.0045
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0484	0.1531	0.1826
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0057	0.0083	0.6886
Leishmania major	protein kinase, putative	0.0067	0.0119	1
Loa Loa (eye worm)	hypothetical protein	0.0484	0.1531	0.1531
Brugia malayi	Plekhf2 protein	0.0044	0.0042	0.0026
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.2502	0.8361	1
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0044	0.0042	0.0045
Echinococcus granulosus	Pleckstrin y	0.0044	0.0042	0.0045
Brugia malayi	Dynamin	0.0044	0.0042	0.0026
Loa Loa (eye worm)	AUR protein kinase	0.0067	0.0119	0.0119
Onchocerca volvulus		0.0044	0.0042	0.0032
Entamoeba histolytica	hypothetical protein	0.0065	0.011	0.0693
Brugia malayi	hypothetical protein	0.0044	0.0042	0.0026
Brugia malayi	MAX-1A	0.0044	0.0042	0.0026
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0044	0.0042	0.0045
Loa Loa (eye worm)	oxysterol binding protein	0.0044	0.0042	0.0042
Echinococcus granulosus	myotubularin protein 13	0.0044	0.0042	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0042	0.0042
Trichomonas vaginalis	conserved hypothetical protein	0.0484	0.1531	1
Loa Loa (eye worm)	hypothetical protein	0.0484	0.1531	0.1531
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0044	0.0042	0.0045
Plasmodium falciparum	PH domain-containing protein, putative	0.0044	0.0042	0.33
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0044	0.0042	0.0247
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0057	0.0083	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0193	0.0545	0.0545
Echinococcus granulosus	exocyst complex component 2	0.0065	0.011	0.0127
Echinococcus granulosus	beta 1 syntrophin	0.0044	0.0042	0.0045
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0057	0.0083	0.6886
Onchocerca volvulus		0.0044	0.0042	0.0032
Entamoeba histolytica	protein kinase, putative	0.0067	0.0119	0.0748
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0042	0.0224
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.0832	1
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0067	0.0119	1
Brugia malayi	PH domain containing protein	0.0044	0.0042	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0484	0.1531	0.1531
Entamoeba histolytica	protein kinase, putative	0.0057	0.0083	0.0515
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0044	0.0042	0.0247
Onchocerca volvulus		0.0044	0.0042	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0042	0.0224
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0044	0.0042	0.0247
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0057	0.0083	0.6886
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0042	0.0042
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0044	0.0042	0.0038
Brugia malayi	Pleckstrin Homology Domain	0.0044	0.0042	0.0026
Giardia lamblia	Aurora kinase	0.0067	0.0119	0.5
Entamoeba histolytica	hypothetical protein	0.0484	0.1531	1
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0044	0.0042	0.0045
Brugia malayi	Oxysterol-binding protein	0.0044	0.0042	0.0026
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0044	0.0042	0.0247
Entamoeba histolytica	tyrosin kinase, putative	0.0086	0.0182	0.1163
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0044	0.0042	0.0247
Echinococcus multilocularis	plexin a4	0.0405	0.1262	0.1504
Entamoeba histolytica	PH domain containing protein	0.0044	0.0042	0.0247
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0057	0.0083	0.6886
Brugia malayi	beta-lactamase family protein	0.0043	0.0039	0.0023
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0057	0.0083	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0039	0.0039
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0044	0.0042	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0039	0.0039
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0052	0.0069	0.0069
Trypanosoma cruzi	hypothetical protein	0.0044	0.0042	0.33
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0391	0.0391
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0044	0.0042	0.0247
Trypanosoma cruzi	hypothetical protein	0.0044	0.0042	0.33
Brugia malayi	beta-lactamase	0.0043	0.0039	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0042	0.0042
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.2502	0.8361	1
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.011	0.0671
Brugia malayi	Sema domain containing protein	0.0147	0.0391	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0042	0.0042
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0057	0.0083	0.0493
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Trichomonas vaginalis	AGC family protein kinase	0.0067	0.0119	0.0727
Echinococcus granulosus	aurora kinase A	0.0067	0.0119	0.0137
Entamoeba histolytica	hypothetical protein	0.0044	0.0042	0.0247
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0044	0.0042	0.0042
Echinococcus multilocularis	Pleckstrin y	0.0044	0.0042	0.0045
Trichomonas vaginalis	centaurin gamma, putative	0.0044	0.0042	0.0224
Entamoeba histolytica	protein kinase domain containing protein	0.0086	0.0182	0.1163
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0039	0.0041
Brugia malayi	A-kinase anchor protein 10, precursor	0.0484	0.1531	0.1517
Loa Loa (eye worm)	PXA domain-containing protein	0.0484	0.1531	0.1531
Schistosoma mansoni	zinc finger protein	0.0044	0.0042	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0042	0.0224
Entamoeba histolytica	protein kinase, putative	0.0067	0.0119	0.0748
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0044	0.0042	0.0038
Loa Loa (eye worm)	syntrophin-1	0.0044	0.0042	0.0042
Echinococcus multilocularis	regulator of G protein signaling 3	0.0484	0.1531	0.1826
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0039	0.0203
Loa Loa (eye worm)	uncoordinated protein 104	0.0044	0.0042	0.0042
Echinococcus multilocularis	beta 1 syntrophin	0.0044	0.0042	0.0045
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Brugia malayi	PH domain containing protein	0.0044	0.0042	0.0026
Brugia malayi	PH domain containing protein	0.0044	0.0042	0.0026
Echinococcus multilocularis	dynamin 1	0.0044	0.0042	0.0045
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0057	0.0083	0.6886
Loa Loa (eye worm)	hypothetical protein	0.0484	0.1531	0.1531
Echinococcus multilocularis	hypothetical protein	0.0147	0.0391	0.0462
Echinococcus granulosus	axis inhibition protein axin	0.0484	0.1531	0.1826
Brugia malayi	plexin A	0.0405	0.1262	0.1247
Loa Loa (eye worm)	sema domain-containing protein	0.0147	0.0391	0.0391
Echinococcus multilocularis	expressed protein	0.0484	0.1531	0.1826
Echinococcus multilocularis	regulator of G protein signaling 3	0.0484	0.1531	0.1826
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0065	0.011	0.0671
Loa Loa (eye worm)	AUR protein kinase	0.0067	0.0119	0.0119
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0039	0.0203
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0044	0.0042	0.0045
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0044	0.0042	0.0224
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0484	0.1531	0.1517
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.2502	0.8361	0.8361
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0044	0.0042	0.0045
Toxoplasma gondii	hypothetical protein	0.0044	0.0042	0.33
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0039	0.0203
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.2502	0.8361	0.8361
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0057	0.0083	0.6886
Echinococcus granulosus	Rho GTPase activating protein 24	0.0044	0.0042	0.0045
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0065	0.011	0.0671
Toxoplasma gondii	protein kinase domain-containing protein	0.0057	0.0083	0.6886
Trichomonas vaginalis	centaurin beta, putative	0.0044	0.0042	0.0224
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0044	0.0042	0.0038
Trypanosoma brucei	PH domain containing protein, putative	0.0044	0.0042	0.33
Schistosoma mansoni	hypothetical protein	0.0065	0.011	0.0106
Trypanosoma cruzi	hypothetical protein	0.0044	0.0042	0.33
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0044	0.0042	0.33
Loa Loa (eye worm)	hypothetical protein	0.0065	0.011	0.011
Brugia malayi	TBC domain containing protein	0.0044	0.0042	0.0026
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0044	0.0042	0.33
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0067	0.0119	0.0137
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0042	0.0224
Schistosoma mansoni	centaurin alpha	0.0044	0.0042	0.0038
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0042	0.0042
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0039	0.0039
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0484	0.1531	0.1531
Schistosoma mansoni	rho gtpase activating protein	0.0044	0.0042	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0042	0.0224
Trichomonas vaginalis	conserved hypothetical protein	0.0484	0.1531	1
Echinococcus multilocularis	transcription factor collier	0.0065	0.011	0.0127
Brugia malayi	Syntrophin-1	0.0044	0.0042	0.0026
Entamoeba histolytica	protein kinase, putative	0.0057	0.0083	0.0515
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Onchocerca volvulus	Putative zinc finger protein	0.0044	0.0042	0.0032
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0039	0.3019
Toxoplasma gondii	Oxysterol-binding protein	0.0044	0.0042	0.33
Brugia malayi	PH domain containing protein	0.0044	0.0042	0.0026
Brugia malayi	Cytohesin 3	0.0044	0.0042	0.0026
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0067	0.0119	0.0748
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0057	0.0083	0.6886
Entamoeba histolytica	protein kinase domain containing protein	0.0067	0.0119	0.0748
Echinococcus granulosus	pleckstrin y domain containing family A	0.0044	0.0042	0.0045
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0057	0.0083	0.0493
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0044	0.0042	0.0045
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0042	0.0224
Trichomonas vaginalis	conserved hypothetical protein	0.0484	0.1531	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0057	0.0083	0.0079
Echinococcus granulosus	oxysterol binding protein 3	0.0044	0.0042	0.0045
Echinococcus granulosus	regulator of G protein signaling 3	0.0484	0.1531	0.1826
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0044	0.0042	0.0042
Loa Loa (eye worm)	PH domain-containing protein	0.0044	0.0042	0.0042
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0057	0.0083	0.6886
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0039	0.0023
Onchocerca volvulus		0.034	0.1043	1
Echinococcus granulosus	cytohesin 1	0.0044	0.0042	0.0045
Trypanosoma cruzi	hypothetical protein	0.0044	0.0042	0.33
Echinococcus multilocularis	beta adrenergic receptor kinase	0.2289	0.764	0.9137
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0042	0.0224
Brugia malayi	Cadps2 protein	0.0044	0.0042	0.0026
Echinococcus multilocularis	Pleckstrin y	0.0044	0.0042	0.0045
Trichomonas vaginalis	kinesin light chain, putative	0.0044	0.0042	0.0224
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0044	0.0042	0.0247
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0065	0.011	0.0671
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0484	0.1531	0.1517
Schistosoma mansoni	serine/threonine protein kinase	0.2289	0.764	0.7639
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Loa Loa (eye worm)	AUR protein kinase	0.0067	0.0119	0.0119
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.011	0.0671
Echinococcus granulosus	regulator of G protein signaling 7	0.0484	0.1531	0.1826
Echinococcus granulosus	oxysterol binding protein 1	0.0044	0.0042	0.0045
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0042	0.0224
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0067	0.0119	0.0748
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0044	0.0042	0.33
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0057	0.0083	0.0515
Echinococcus multilocularis	Oxysterol binding protein 11	0.0044	0.0042	0.0045
Entamoeba histolytica	protein kinase, putative	0.0057	0.0083	0.0515
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0057	0.0083	0.0515
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Echinococcus multilocularis	Pleckstrin y	0.0044	0.0042	0.0045
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0044	0.0042	0.0045
Trypanosoma cruzi	hypothetical protein	0.0044	0.0042	0.33
Brugia malayi	IPT/TIG domain containing protein	0.0065	0.011	0.0094
Schistosoma mansoni	serine/threonine protein kinase	0.2289	0.764	0.7639
Entamoeba histolytica	PH domain containing protein	0.0044	0.0042	0.0247
Entamoeba histolytica	protein kinase, putative	0.0057	0.0083	0.0515
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0057	0.0083	0.0515
Brugia malayi	DNA-binding protein LAG-1	0.0065	0.011	0.0094
Trichomonas vaginalis	conserved hypothetical protein	0.0484	0.1531	1
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0044	0.0042	0.0045
Brugia malayi	probable spectrin beta chain	0.0044	0.0042	0.0026
Trypanosoma cruzi	NIMA-related kinase, putative	0.0057	0.0083	0.6886
Trypanosoma brucei	protein kinase, putative	0.0057	0.0083	0.6886
Trichomonas vaginalis	centaurin/arf, putative	0.0044	0.0042	0.0224
Loa Loa (eye worm)	Plekhf2 protein	0.0044	0.0042	0.0042
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0044	0.0042	0.0045
Echinococcus granulosus	Pleckstrin y	0.0044	0.0042	0.0045
Brugia malayi	Dynamin	0.0044	0.0042	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0042	0.0224
Schistosoma mansoni	serine/threonine-protein kinase	0.0057	0.0083	0.0079
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0044	0.0042	0.0045
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0039	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0042	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0042	0.0042
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0044	0.0042	0.0042
Schistosoma mansoni	zinc finger protein	0.0044	0.0042	0.0038
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0044	0.0042	0.33
Leishmania major	hypothetical protein, conserved	0.0043	0.0039	0.3019
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0044	0.0042	0.0032
Echinococcus granulosus	GRB2 associated binding protein 3	0.0044	0.0042	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0391	0.0391
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0044	0.0042	0.0026
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0044	0.0042	0.0224
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.0119	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0065	0.011	0.011
Echinococcus granulosus	calcium dependent secretion activator 1	0.0044	0.0042	0.0045
Trypanosoma cruzi	Protein kinase B	0.0057	0.0083	0.6886
Entamoeba histolytica	hypothetical protein	0.0044	0.0042	0.0247
Trichomonas vaginalis	esterase, putative	0.0043	0.0039	0.0203
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0484	0.1531	1
Brugia malayi	Sema domain containing protein	0.0147	0.0391	0.0375
Brugia malayi	Oxysterol binding protein	0.0044	0.0042	0.0026
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0044	0.0042	0.33
Loa Loa (eye worm)	hypothetical protein	0.0065	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0042	0.0042
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0042	0.0224
Mycobacterium ulcerans	lipase LipD	0.0043	0.0039	0.5
Trichomonas vaginalis	hypothetical protein	0.0044	0.0042	0.0224
Trypanosoma brucei	aurora B kinase	0.0067	0.0119	1
Schistosoma mansoni	hypothetical protein	0.0044	0.0042	0.0038
Entamoeba histolytica	hypothetical protein	0.0057	0.0083	0.0515
Brugia malayi	Variant SH3 domain containing protein	0.0044	0.0042	0.0026
Entamoeba histolytica	hypothetical protein	0.0065	0.011	0.0693
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0042	0.0042
Trichomonas vaginalis	protein transport protein sec7, putative	0.0044	0.0042	0.0224
Brugia malayi	hypothetical protein	0.0147	0.0391	0.0375
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0044	0.0042	0.0045
Loa Loa (eye worm)	cytohesin 3	0.0044	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0391	0.0391
Echinococcus granulosus	regulator of G protein signaling 3	0.0484	0.1531	0.1826
Schistosoma mansoni	regulator of G protein signaling	0.0484	0.1531	0.1527
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0044	0.0042	0.0247
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.2502	0.8361	0.8358
Schistosoma mansoni	dynamin	0.0044	0.0042	0.0038
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0057	0.0083	0.5539
Brugia malayi	Uncoordinated protein 104	0.0044	0.0042	0.0026
Echinococcus multilocularis	oxysterol binding protein 3	0.0044	0.0042	0.0045
Echinococcus multilocularis	regulator of G protein signaling 7	0.0484	0.1531	0.1826
Schistosoma mansoni	protein kinase	0.0067	0.0119	0.0114
Echinococcus multilocularis	regulator of G protein signaling	0.0484	0.1531	0.1826
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0044	0.0042	0.0026
Brugia malayi	serine/threonine kinase 12	0.0067	0.0119	0.0103
Schistosoma mansoni	oxysterol-binding protein 1	0.0044	0.0042	0.0038
Brugia malayi	hypothetical protein	0.0147	0.0391	0.0375
Echinococcus granulosus	G protein coupled receptor kinase 1	0.1805	0.6001	0.7176
Echinococcus multilocularis	regulator of G protein signaling 7	0.0484	0.1531	0.1826
Brugia malayi	PH domain containing protein	0.0044	0.0042	0.0026
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0044	0.0042	0.33
Entamoeba histolytica	hypothetical protein	0.0044	0.0042	0.0247
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0044	0.0042	0.0045
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0044	0.0042	0.33
Schistosoma mansoni	vesicular amine transporter	0.0034	0.0006	0.0001
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0065	0.011	0.0671
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0042	0.0224
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0057	0.0083	0.6886
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0044	0.0042	0.0026
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0044	0.0042	0.0045
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0028	0.0023
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0057	0.0083	0.6886
Schistosoma mansoni	vav2	0.0044	0.0042	0.0038
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0044	0.0042	0.0045
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0044	0.0042	0.0247
Schistosoma mansoni	fibrocystin l	0.0065	0.011	0.0106
Trypanosoma cruzi	PH domain containing protein, putative	0.0044	0.0042	0.33
Schistosoma mansoni	hypothetical protein	0.0065	0.011	0.0106
Entamoeba histolytica	protein kinase, putative	0.0057	0.0083	0.0515
Brugia malayi	serine/threonine protein kinase 6	0.0067	0.0119	0.0103
Trichomonas vaginalis	AGC family protein kinase	0.0057	0.0083	0.0493
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0044	0.0042	0.33
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0065	0.011	0.0671
Onchocerca volvulus	outspread protein homolog	0.0044	0.0042	0.0032
Echinococcus multilocularis	oxysterol binding protein 9	0.0044	0.0042	0.0045
Schistosoma mansoni	goodpasture antigen-binding protein	0.0044	0.0042	0.0038
Schistosoma mansoni	hypothetical protein	0.0044	0.0042	0.0038
Schistosoma mansoni	regulator of G protein signaling	0.0484	0.1531	0.1527
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0042	0.0042
Entamoeba histolytica	hypothetical protein	0.0044	0.0042	0.0247
Toxoplasma gondii	hypothetical protein	0.0044	0.0042	0.33
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0042	0.0042
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0067	0.0119	0.0748
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0044	0.0042	0.0403
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0052	0.0069	0.0053
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0044	0.0042	0.0042
Leishmania major	folate/biopterin transporter, putative	0.0057	0.0083	0.6886
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0044	0.0042	0.0247
Brugia malayi	PH domain containing protein	0.0044	0.0042	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0042	0.0042
Loa Loa (eye worm)	rho-GTPase-activating	0.0044	0.0042	0.0042
Schistosoma mansoni	hypothetical protein	0.0044	0.0042	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0484	0.1531	0.1531
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0039	0.0039
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0039	0.0203
Onchocerca volvulus		0.0044	0.0042	0.0032
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0044	0.0042	0.0045
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0044	0.0042	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0065	0.011	0.011
Leishmania major	hypothetical protein, conserved	0.0044	0.0042	0.33
Echinococcus granulosus	pdz domain containing protein	0.0044	0.0042	0.0045
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0037	0.0016	0.0016

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 9.09 uM	Inhibition of Enterobacter cloacae P99 beta-lactamase AmpC P99 using nitrocefin as substrate after 30 mins by spectrophotometric analysis	ChEMBL.	21392987

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1761092

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1510191