Detailed information for compound 1510192

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 258.101 | Formula: C13H11BO3S
  • H donors: 2 H acceptors: 2 LogP: 2.53 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][S+](c1ccc2c(c1)B(O)OC2)c1ccccc1
  • InChi: 1S/C13H11BO3S/c15-14-13-8-12(7-6-10(13)9-17-14)18(16)11-4-2-1-3-5-11/h1-8,15H,9H2
  • InChiKey: GUIBVAKSFMFXJA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi PH domain containing protein, putative 0.0055 0.0057 0.3626
Entamoeba histolytica cell surface protease gp63, putative 0.0097 0.0171 0.0917
Loa Loa (eye worm) hypothetical protein 0.0055 0.0057 0.0051
Schistosoma mansoni regulator of G protein signaling 0.0602 0.1543 0.1543
Toxoplasma gondii Oxysterol-binding protein 0.0055 0.0057 0.3626
Entamoeba histolytica hypothetical protein 0.0602 0.1543 1
Echinococcus granulosus G protein coupled receptor kinase 1 0.2245 0.6007 0.7181
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0057 0.0352
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0055 0.0057 0.0062
Loa Loa (eye worm) hypothetical protein 0.0519 0.1318 0.1313
Brugia malayi Plexin repeat family protein 0.0519 0.1318 0.1313
Brugia malayi PH domain containing protein 0.0055 0.0057 0.0051
Entamoeba histolytica hypothetical protein 0.0097 0.0171 0.0917
Trypanosoma cruzi rac serine-threonine kinase, putative 0.007 0.0098 0.9749
Loa Loa (eye worm) hypothetical protein 0.0055 0.0057 0.0051
Brugia malayi Sema domain containing protein 0.0222 0.0511 0.0505
Schistosoma mansoni regulator of G protein signaling 0.0602 0.1543 0.1543
Brugia malayi A-kinase anchor protein 10, precursor 0.0602 0.1543 0.1538
Echinococcus multilocularis exocyst complex component 2 0.0097 0.0171 0.0199
Loa Loa (eye worm) hypothetical protein 0.0602 0.1543 0.1538
Loa Loa (eye worm) TK/ALK protein kinase 0.0286 0.0683 0.0677
Schistosoma mansoni serine/threonine-protein kinase 0.007 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0055 0.0057 0.0051
Loa Loa (eye worm) hypothetical protein 0.0055 0.0057 0.0051
Brugia malayi Protein kinase domain containing protein 0.0286 0.0683 0.0678
Schistosoma mansoni axis inhibition protein axin 0.0602 0.1543 0.1543
Loa Loa (eye worm) oxysterol binding protein 0.0055 0.0057 0.0051
Loa Loa (eye worm) hypothetical protein 0.0224 0.0515 0.0509
Echinococcus granulosus cytohesin 1 0.0055 0.0057 0.0062
Leishmania major hypothetical protein, conserved 0.0055 0.0057 0.3626
Echinococcus multilocularis Pleckstrin y 0.0055 0.0057 0.0062
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0055 0.0057 0.0051
Entamoeba histolytica PH domain containing protein kinase, putative 0.007 0.0098 0.0428
Schistosoma mansoni vav2 0.0055 0.0057 0.0057
Echinococcus multilocularis transcription factor collier 0.0097 0.0171 0.0199
Echinococcus granulosus axis inhibition protein axin 0.0602 0.1543 0.184
Loa Loa (eye worm) cytohesin 3 0.0055 0.0057 0.0051
Echinococcus multilocularis pleckstrin y domain containing family A 0.0055 0.0057 0.0062
Echinococcus multilocularis oxysterol binding protein 1 0.0055 0.0057 0.0062
Echinococcus granulosus DCC interacting protein 13 beta 0.0055 0.0057 0.0062
Schistosoma mansoni fibrocystin l 0.0097 0.0171 0.0171
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Entamoeba histolytica hypothetical protein 0.0055 0.0057 0.0159
Schistosoma mansoni hypothetical protein 0.0222 0.0511 0.0511
Loa Loa (eye worm) AUR protein kinase 0.0071 0.0099 0.0093
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.007 0.0098 0.9749
Entamoeba histolytica protein kinase, putative 0.007 0.0098 0.0428
Loa Loa (eye worm) rho-GTPase-activating 0.0055 0.0057 0.0051
Entamoeba histolytica protein kinase, putative 0.0071 0.0099 0.0439
Entamoeba histolytica p21-activated kinase 0.007 0.0098 0.0428
Echinococcus multilocularis roundabout 2 0.0037 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0055 0.0057 0.0051
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.007 0.0098 0.9749
Schistosoma mansoni dynamin 0.0055 0.0057 0.0057
Trypanosoma cruzi rac serine-threonine kinase, putative 0.007 0.0098 0.9749
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0055 0.0057 0.0062
Entamoeba histolytica hypothetical protein 0.0055 0.0057 0.0159
Brugia malayi IPT/TIG domain containing protein 0.0097 0.0171 0.0165
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0055 0.0057 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0057 0.0352
Schistosoma mansoni hypothetical protein 0.0097 0.0171 0.0171
Echinococcus granulosus dynamin 1 0.0055 0.0057 0.0062
Brugia malayi Oxysterol binding protein 0.0055 0.0057 0.0051
Entamoeba histolytica protein kinase, putative 0.007 0.0098 0.0428
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0055 0.0057 0.0159
Schistosoma mansoni hypothetical protein 0.0297 0.0714 0.0714
Trypanosoma cruzi Protein kinase B 0.007 0.0098 0.9749
Toxoplasma gondii AtPH1 family protein 0.0055 0.0057 0.3626
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0057 0.0352
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0055 0.0057 0.0352
Entamoeba histolytica hypothetical protein 0.007 0.0098 0.0428
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0055 0.0057 0.0159
Loa Loa (eye worm) hypothetical protein 0.0055 0.0057 0.0051
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0071 0.0099 0.0439
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0055 0.0057 0.0352
Entamoeba histolytica protein kinase, putative 0.007 0.0098 0.0428
Echinococcus granulosus serine/threonine protein kinase 0.007 0.0098 0.0111
Entamoeba histolytica tyrosin kinase, putative 0.0129 0.0257 0.1483
Loa Loa (eye worm) AUR protein kinase 0.0071 0.0099 0.0093
Brugia malayi serine/threonine-protein kinase 6 0.0071 0.0099 0.0093
Brugia malayi Plekhf2 protein 0.0055 0.0057 0.0051
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0055 0.0057 0.0062
Trypanosoma cruzi NIMA-related kinase, putative 0.007 0.0098 0.9749
Trichomonas vaginalis centaurin/arf, putative 0.0055 0.0057 0.0352
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0055 0.0057 0.0159
Brugia malayi regulator of G-protein signaling egl-10 0.0602 0.1543 0.1538
Schistosoma mansoni oxysterol-binding protein 1 0.0055 0.0057 0.0057
Schistosoma mansoni myotubularin-related protein 0.0055 0.0057 0.0057
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Echinococcus multilocularis beta 1 syntrophin 0.0055 0.0057 0.0062
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0055 0.0057 0.0414
Loa Loa (eye worm) hypothetical protein 0.0097 0.0171 0.0165
Brugia malayi PH domain containing protein 0.0055 0.0057 0.0051
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.3112 0.8364 0.8363
Brugia malayi PH domain containing protein 0.0055 0.0057 0.0051
Schistosoma mansoni plexin 0.0297 0.0714 0.0714
Echinococcus multilocularis Rho GTPase activating protein 24 0.0055 0.0057 0.0062
Echinococcus granulosus Pleckstrin y 0.0055 0.0057 0.0062
Entamoeba histolytica protein kinase, putative 0.007 0.0098 0.0428
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.007 0.0098 0.9749
Entamoeba histolytica hypothetical protein, conserved 0.0055 0.0057 0.0159
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.007 0.0098 0.0616
Echinococcus multilocularis myotubularin protein 13 0.0055 0.0057 0.0062
Schistosoma mansoni ephrin receptor 0.0036 0.0005 0.0005
Loa Loa (eye worm) plexin A 0.0617 0.1582 0.1577
Loa Loa (eye worm) hypothetical protein 0.0055 0.0057 0.0051
Trypanosoma brucei aurora B kinase 0.0071 0.0099 1
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0055 0.0057 0.0057
Trypanosoma brucei PH domain containing protein, putative 0.0055 0.0057 0.3626
Onchocerca volvulus 0.0055 0.0057 0.0414
Leishmania major hypothetical protein, conserved 0.0055 0.0057 0.3626
Entamoeba histolytica protein kinase domain containing protein 0.0071 0.0099 0.0439
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0057 0.0352
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0055 0.0057 0.3626
Echinococcus multilocularis axis inhibition protein axin 0.0602 0.1543 0.184
Echinococcus granulosus semaphorin 5B 0.0222 0.0511 0.0605
Echinococcus granulosus regulator of G protein signaling 3 0.0602 0.1543 0.184
Entamoeba histolytica ARF GTPase activating protein, putative 0.0055 0.0057 0.0159
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0071 0.0099 0.0113
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0099 0.0626
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0055 0.0057 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0057 0.0352
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0055 0.0057 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.0171 0.1095
Entamoeba histolytica protein kinase, putative 0.007 0.0098 0.0428
Schistosoma mansoni semaphorin 5-related 0.0222 0.0511 0.0511
Trichomonas vaginalis hypothetical protein 0.0055 0.0057 0.0352
Brugia malayi PH domain containing protein 0.0055 0.0057 0.0051
Schistosoma mansoni regulator of G protein signaling 0.0602 0.1543 0.1543
Schistosoma mansoni syntrophin 0.0055 0.0057 0.0057
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Brugia malayi serine/threonine kinase 12 0.0071 0.0099 0.0093
Plasmodium falciparum serine/threonine protein kinase, putative 0.0071 0.0099 1
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0055 0.0057 0.3626
Loa Loa (eye worm) hypothetical protein 0.0055 0.0057 0.0051
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0055 0.0057 0.0352
Brugia malayi Pleckstrin Homology Domain 0.0055 0.0057 0.0051
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0055 0.0057 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.0171 0.1095
Echinococcus multilocularis beta adrenergic receptor kinase 0.2847 0.7643 0.9139
Brugia malayi Probable exocyst complex component Sec5 0.0097 0.0171 0.0165
Trichomonas vaginalis centaurin gamma, putative 0.0055 0.0057 0.0352
Brugia malayi probable spectrin beta chain 0.0055 0.0057 0.0051
Echinococcus granulosus Pleckstrin y 0.0055 0.0057 0.0062
Entamoeba histolytica hypothetical protein 0.0055 0.0057 0.0159
Trichomonas vaginalis protein transport protein sec7, putative 0.0055 0.0057 0.0352
Trypanosoma cruzi serine/threonine protein kinase, putative 0.007 0.0098 0.9749
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.3112 0.8364 1
Brugia malayi Variant SH3 domain containing protein 0.0055 0.0057 0.0051
Brugia malayi Dynamin 0.0055 0.0057 0.0051
Loa Loa (eye worm) PH domain-containing protein 0.0055 0.0057 0.0051
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.2847 0.7643 0.7642
Trypanosoma cruzi NIMA-related kinase, putative 0.007 0.0098 0.9749
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0055 0.0057 0.0159
Echinococcus granulosus tyrosine protein kinase Lyn 0.0046 0.0033 0.0033
Brugia malayi regulator of G-protein signaling rgs-7 0.0602 0.1543 0.1538
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0055 0.0057 0.0159
Entamoeba histolytica PH domain containing protein 0.0055 0.0057 0.0159
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0099 0.0626
Onchocerca volvulus Putative zinc finger protein 0.0055 0.0057 0.0414
Schistosoma mansoni centaurin alpha 0.0055 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0097 0.0171 0.0165
Echinococcus multilocularis oxysterol binding protein 3 0.0055 0.0057 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0602 0.1543 1
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0055 0.0057 0.0159
Brugia malayi Regulator of G protein signaling domain containing protein 0.0602 0.1543 0.1538
Brugia malayi hypothetical protein 0.0222 0.0511 0.0505
Loa Loa (eye worm) hypothetical protein 0.0055 0.0057 0.0051
Echinococcus multilocularis regulator of G protein signaling 3 0.0602 0.1543 0.184
Schistosoma mansoni growth factor receptor-bound protein 0.0055 0.0057 0.0057
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0019 0.0019
Trypanosoma cruzi PH domain containing protein, putative 0.0055 0.0057 0.3626
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0063 0.0079 0.0073
Echinococcus multilocularis regulator of G protein signaling 7 0.0602 0.1543 0.184
Echinococcus multilocularis aurora kinase A 0.0071 0.0099 0.0113
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0055 0.0057 0.0159
Entamoeba histolytica protein kinase, putative 0.007 0.0098 0.0428
Loa Loa (eye worm) hypothetical protein 0.0602 0.1543 0.1538
Entamoeba histolytica hypothetical protein 0.0097 0.0171 0.0917
Loa Loa (eye worm) hypothetical protein 0.0055 0.0057 0.0051
Echinococcus granulosus transcription factor collier 0.0097 0.0171 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0602 0.1543 1
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0057 0.0352
Trypanosoma cruzi hypothetical protein 0.0055 0.0057 0.3626
Loa Loa (eye worm) hypothetical protein 0.0055 0.0057 0.0051
Toxoplasma gondii hypothetical protein 0.0055 0.0057 0.3626
Toxoplasma gondii hypothetical protein 0.0055 0.0057 0.3626
Echinococcus multilocularis DCC interacting protein 13 beta 0.0055 0.0057 0.0062
Brugia malayi Syntrophin-1 0.0055 0.0057 0.0051
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.007 0.0098 0.0616
Giardia lamblia Aurora kinase 0.0071 0.0099 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.0057 0.0051
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0055 0.0057 0.0051
Entamoeba histolytica hypothetical protein 0.0055 0.0057 0.0159
Toxoplasma gondii phosphatidylinositol transfer protein 0.0055 0.0057 0.3626
Echinococcus multilocularis regulator of G protein signaling 3 0.0602 0.1543 0.184
Loa Loa (eye worm) hypothetical protein 0.0297 0.0714 0.0708
Brugia malayi plexin A 0.0617 0.1582 0.1577
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0019 0.0019
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0071 0.0099 0.0439
Brugia malayi Immunoglobulin I-set domain containing protein 0.0063 0.0079 0.0073
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0009 0.0005
Loa Loa (eye worm) Plekhf2 protein 0.0055 0.0057 0.0051
Echinococcus granulosus Regulator of G protein signaling 20 0.0602 0.1543 0.184
Loa Loa (eye worm) hypothetical protein 0.0055 0.0057 0.0051
Brugia malayi hypothetical protein 0.0602 0.1543 0.1538
Onchocerca volvulus 0.0055 0.0057 0.0414
Leishmania major protein kinase, putative 0.007 0.0098 0.9749
Entamoeba histolytica hypothetical protein 0.0602 0.1543 1
Echinococcus granulosus roundabout 2 0.0037 0.0006 0.0001
Brugia malayi TBC domain containing protein 0.0055 0.0057 0.0051
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0055 0.0057 0.0352
Entamoeba histolytica protein kinase, putative 0.0071 0.0099 0.0439
Leishmania major protein kinase, putative 0.0071 0.0099 1
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0602 0.1543 1
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0055 0.0057 0.0352
Loa Loa (eye worm) hypothetical protein 0.0602 0.1543 0.1538
Schistosoma mansoni oxysterol-binding protein 1 0.0055 0.0057 0.0057
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0602 0.1543 0.1538
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0055 0.0057 0.0414
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0099 0.0626
Trypanosoma cruzi aurora B kinase, putative 0.0071 0.0099 1
Schistosoma mansoni z-protein (S1r protein) 0.0602 0.1543 0.1543
Echinococcus multilocularis GRB2 associated binding protein 3 0.0055 0.0057 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0057 0.0352
Loa Loa (eye worm) hypothetical protein 0.0602 0.1543 0.1538
Echinococcus multilocularis actin binding protein anillin 0.0055 0.0057 0.0062
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0055 0.0057 0.0159
Echinococcus granulosus pleckstrin y domain containing family A 0.0055 0.0057 0.0062
Brugia malayi Cytohesin 3 0.0055 0.0057 0.0051
Trichomonas vaginalis centaurin beta, putative 0.0055 0.0057 0.0352
Echinococcus multilocularis rac serine:threonine kinase 0.007 0.0098 0.0111
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0071 0.0099 0.0439
Echinococcus multilocularis dynamin 1 0.0055 0.0057 0.0062
Onchocerca volvulus outspread protein homolog 0.0055 0.0057 0.0414
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0055 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0055 0.0057 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0602 0.1543 1
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.007 0.0098 0.9749
Echinococcus granulosus pdz domain containing protein 0.0055 0.0057 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0057 0.0352
Schistosoma mansoni dynamin 0.0055 0.0057 0.0057
Loa Loa (eye worm) AUR protein kinase 0.0071 0.0099 0.0093
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Echinococcus granulosus semaphorin 1A 0.0222 0.0511 0.0605
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0055 0.0057 0.0062
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0055 0.0057 0.3626
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0071 0.0099 0.0113
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0055 0.0057 0.0051
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0055 0.0057 0.0062
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0009 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0057 0.0352
Echinococcus granulosus expressed protein 0.0602 0.1543 0.184
Entamoeba histolytica protein kinase, putative 0.007 0.0098 0.0428
Entamoeba histolytica PH domain containing protein kinase, putative 0.007 0.0098 0.0428
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0055 0.0057 0.0062
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0055 0.0057 0.0159
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0602 0.1543 0.184
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.3112 0.8364 0.8363
Loa Loa (eye worm) hypothetical protein 0.0602 0.1543 0.1538
Schistosoma mansoni hypothetical protein 0.0055 0.0057 0.0057
Echinococcus multilocularis Ras associated and pleckstrin y 0.0055 0.0057 0.0062
Brugia malayi Oxysterol-binding protein 0.0055 0.0057 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.2847 0.7643 0.7643
Trypanosoma cruzi PH domain containing protein, putative 0.0055 0.0057 0.3626
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.007 0.0098 0.9749
Loa Loa (eye worm) sema domain-containing protein 0.0222 0.0511 0.0505
Trypanosoma cruzi hypothetical protein 0.0055 0.0057 0.3626
Loa Loa (eye worm) hypothetical protein 0.0055 0.0057 0.0051
Entamoeba histolytica PH domain containing protein 0.0055 0.0057 0.0159
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.007 0.0098 0.9749
Echinococcus granulosus plexin a4 0.0617 0.1582 0.1887
Brugia malayi PH domain containing protein 0.0055 0.0057 0.0051
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Loa Loa (eye worm) uncoordinated protein 104 0.0055 0.0057 0.0051
Entamoeba histolytica PH domain containing protein kinase, putative 0.007 0.0098 0.0428
Schistosoma mansoni regulator of G protein signaling 0.0602 0.1543 0.1543
Loa Loa (eye worm) hypothetical protein 0.0097 0.0171 0.0165
Loa Loa (eye worm) hypothetical protein 0.0097 0.0171 0.0165
Echinococcus granulosus regulator of G protein signaling 7 0.0602 0.1543 0.184
Echinococcus granulosus Pleckstrin y 0.0055 0.0057 0.0062
Loa Loa (eye worm) PXA domain-containing protein 0.0602 0.1543 0.1538
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Schistosoma mansoni hypothetical protein 0.0055 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0057 0.0352
Brugia malayi serine/threonine protein kinase 6 0.0071 0.0099 0.0093
Loa Loa (eye worm) hypothetical protein 0.0055 0.0057 0.0051
Schistosoma mansoni protein kinase 0.0046 0.0033 0.0033
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0055 0.0057 0.0159
Echinococcus multilocularis plexin a4 0.0617 0.1582 0.1887
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0055 0.0057 0.0062
Loa Loa (eye worm) RGS-3 protein 0.0602 0.1543 0.1538
Schistosoma mansoni hypothetical protein 0.0222 0.0511 0.0511
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0097 0.0171 0.1095
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.0171 0.1095
Loa Loa (eye worm) hypothetical protein 0.0222 0.0511 0.0505
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0055 0.0057 0.0159
Echinococcus multilocularis axis inhibition protein axin 0.0602 0.1543 0.184
Loa Loa (eye worm) syntrophin-1 0.0055 0.0057 0.0051
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0055 0.0057 0.0062
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0071 0.0099 1
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0055 0.0057 0.0057
Schistosoma mansoni protein kinase 0.0046 0.0033 0.0033
Schistosoma mansoni goodpasture antigen-binding protein 0.0055 0.0057 0.0057
Entamoeba histolytica hypothetical protein 0.0055 0.0057 0.0159
Brugia malayi hypothetical protein 0.0222 0.0511 0.0505
Echinococcus granulosus calcium dependent secretion activator 1 0.0055 0.0057 0.0062
Echinococcus granulosus oxysterol binding protein 1 0.0055 0.0057 0.0062
Schistosoma mansoni nephrin 0.0037 0.0006 0.0006
Trichomonas vaginalis alpha chimerin, putative 0.0055 0.0057 0.0352
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Leishmania major serine/threonine-protein kinase a, putative 0.007 0.0098 0.9749
Brugia malayi Variant SH3 domain containing protein 0.0055 0.0057 0.0051
Loa Loa (eye worm) hypothetical protein 0.0055 0.0057 0.0051
Loa Loa (eye worm) hypothetical protein 0.0222 0.0511 0.0505
Trypanosoma brucei protein kinase, putative 0.007 0.0098 0.9749
Brugia malayi Dynamin 0.0055 0.0057 0.0051
Brugia malayi PH domain containing protein 0.0055 0.0057 0.0051
Echinococcus multilocularis pdz domain containing protein 0.0055 0.0057 0.0062
Echinococcus multilocularis Regulator of G protein signaling 20 0.0602 0.1543 0.184
Trichomonas vaginalis conserved hypothetical protein 0.0602 0.1543 1
Onchocerca volvulus 0.0055 0.0057 0.0414
Loa Loa (eye worm) hypothetical protein 0.0055 0.0057 0.0051
Trypanosoma cruzi hypothetical protein 0.0055 0.0057 0.3626
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.007 0.0098 0.9607
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Echinococcus multilocularis G protein coupled receptor kinase 6 0.3112 0.8364 1
Schistosoma mansoni rho gtpase activating protein 0.0055 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0602 0.1543 0.1538
Brugia malayi MAX-1A 0.0055 0.0057 0.0051
Onchocerca volvulus 0.0055 0.0057 0.0414
Trypanosoma cruzi hypothetical protein 0.0055 0.0057 0.3626
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0602 0.1543 0.1543
Onchocerca volvulus 0.0055 0.0057 0.0414
Onchocerca volvulus 0.0055 0.0057 0.0414
Echinococcus multilocularis hypothetical protein 0.0222 0.0511 0.0605
Entamoeba histolytica hypothetical protein 0.0097 0.0171 0.0917
Echinococcus multilocularis activin receptor type 0.0046 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0222 0.0511 0.0505
Echinococcus granulosus aurora kinase A 0.0071 0.0099 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.0171 0.1095
Echinococcus granulosus twitchin 0.0047 0.0034 0.0034
Echinococcus granulosus regulator of G protein signaling 3 0.0602 0.1543 0.184
Echinococcus granulosus activin receptor type 0.0046 0.0033 0.0033
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.007 0.0098 0.9749
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0055 0.0057 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0057 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0602 0.1543 1
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0057 0.0352
Echinococcus multilocularis G protein coupled receptor kinase 1 0.2245 0.6007 0.7181
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0055 0.0057 0.0159
Brugia malayi PXA domain containing protein 0.0602 0.1543 0.1538
Trypanosoma cruzi hypothetical protein 0.0055 0.0057 0.3626
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0055 0.0057 0.3626
Echinococcus granulosus oxysterol binding protein 3 0.0055 0.0057 0.0062
Schistosoma mansoni zinc finger protein 0.0055 0.0057 0.0057
Echinococcus multilocularis semaphorin 5B 0.0222 0.0511 0.0605
Entamoeba histolytica hypothetical protein 0.007 0.0098 0.0428
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0057 0.0352
Brugia malayi Uncoordinated protein 104 0.0055 0.0057 0.0051
Echinococcus granulosus myotubularin protein 13 0.0055 0.0057 0.0062
Plasmodium falciparum PH domain-containing protein, putative 0.0055 0.0057 0.3626
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0057 0.0352
Echinococcus granulosus beta 1 syntrophin 0.0055 0.0057 0.0062
Echinococcus granulosus regulator of G protein signaling 7 0.0602 0.1543 0.184
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0097 0.0171 0.1095
Brugia malayi Cadps2 protein 0.0055 0.0057 0.0051
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0097 0.0171 0.1095
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Trypanosoma cruzi hypothetical protein 0.0055 0.0057 0.3626
Schistosoma mansoni plexin 0.0519 0.1318 0.1318
Echinococcus granulosus oxysterol binding protein 9 0.0055 0.0057 0.0062
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.3112 0.8364 0.8363
Leishmania major folate/biopterin transporter, putative 0.007 0.0098 0.9749
Schistosoma mansoni protein kinase 0.0071 0.0099 0.0099
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0055 0.0057 0.3626
Schistosoma mansoni axis inhibition protein axin 0.0602 0.1543 0.1543
Toxoplasma gondii protein kinase domain-containing protein 0.007 0.0098 0.9749
Brugia malayi PH domain containing protein 0.0055 0.0057 0.0051
Brugia malayi PXA domain containing protein 0.0602 0.1543 0.1538
Schistosoma mansoni hypothetical protein 0.0055 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.0171 0.1095
Echinococcus granulosus axis inhibition protein axin 0.0602 0.1543 0.184
Echinococcus multilocularis Pleckstrin y 0.0055 0.0057 0.0062
Echinococcus granulosus Rho GTPase activating protein 24 0.0055 0.0057 0.0062
Loa Loa (eye worm) sema domain-containing protein 0.0222 0.0511 0.0505
Trichomonas vaginalis centaurin alpha, putative 0.0055 0.0057 0.0352
Echinococcus granulosus exocyst complex component 2 0.0097 0.0171 0.0199
Onchocerca volvulus Protein melted homolog 0.0055 0.0057 0.0414
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0055 0.0057 0.0062
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Echinococcus multilocularis Pleckstrin y 0.0055 0.0057 0.0062
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.007 0.0098 0.9749
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.0171 0.1095
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0046 0.0033 0.0033
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0055 0.0057 0.0051
Trichomonas vaginalis AGC family protein kinase 0.0071 0.0099 0.0626
Brugia malayi Protein kinase domain containing protein 0.007 0.0098 0.0091
Trypanosoma cruzi hypothetical protein 0.0055 0.0057 0.3626
Echinococcus granulosus GRB2 associated binding protein 3 0.0055 0.0057 0.0062
Brugia malayi PH domain containing protein 0.0055 0.0057 0.0051
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.007 0.0098 0.9749
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0097 0.0171 0.1095
Trichomonas vaginalis centaurin/arf, putative 0.0055 0.0057 0.0352
Loa Loa (eye worm) hypothetical protein 0.0055 0.0057 0.0051
Entamoeba histolytica protein kinase domain containing protein 0.0129 0.0257 0.1483
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0046 0.0033 0.0033
Echinococcus multilocularis Oxysterol binding protein 11 0.0055 0.0057 0.0062
Entamoeba histolytica PH domain containing protein kinase, putative 0.007 0.0098 0.0428
Loa Loa (eye worm) AGC/AKT protein kinase 0.007 0.0098 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0057 0.0352
Onchocerca volvulus 0.0055 0.0057 0.0414
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0057 0.0352
Trichomonas vaginalis kinesin light chain, putative 0.0055 0.0057 0.0352
Loa Loa (eye worm) hypothetical protein 0.0222 0.0511 0.0505
Schistosoma mansoni zinc finger protein 0.0055 0.0057 0.0057
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.007 0.0098 0.9749
Schistosoma mansoni serine/threonine protein kinase 0.2847 0.7643 0.7643
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0602 0.1543 0.184
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0009 0.0003
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0055 0.0057 0.0062
Echinococcus multilocularis regulator of G protein signaling 7 0.0602 0.1543 0.184
Echinococcus multilocularis calcium dependent secretion activator 1 0.0055 0.0057 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.0171 0.1095
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0055 0.0057 0.0062
Schistosoma mansoni hypothetical protein 0.0055 0.0057 0.0057
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.007 0.0098 0.9749
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0099 0.0099
Echinococcus granulosus Oxysterol binding protein 11 0.0055 0.0057 0.0062
Entamoeba histolytica PH domain containing protein 0.0055 0.0057 0.0159
Schistosoma mansoni serine/threonine-protein kinase 0.007 0.0098 0.0098
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0055 0.0057 0.0062
Brugia malayi hypothetical protein 0.0055 0.0057 0.0051
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Entamoeba histolytica hypothetical protein 0.0097 0.0171 0.0917
Trichomonas vaginalis conserved hypothetical protein 0.0602 0.1543 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.007 0.0098 0.9749
Schistosoma mansoni regulator of G protein signaling 0.0602 0.1543 0.1543
Brugia malayi hypothetical protein 0.0602 0.1543 0.1538
Entamoeba histolytica protein kinase , putative 0.0071 0.0099 0.0439
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0055 0.0057 0.0062
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.007 0.0098 0.9749
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0055 0.0057 0.0159
Entamoeba histolytica hypothetical protein 0.0602 0.1543 1
Echinococcus multilocularis regulator of G protein signaling 0.0602 0.1543 0.184
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0055 0.0057 0.0062
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0055 0.0057 0.0057
Toxoplasma gondii aurora kinase 0.0071 0.0099 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0057 0.0051
Loa Loa (eye worm) hypothetical protein 0.0222 0.0511 0.0505
Leishmania major protein kinase, putative 0.007 0.0098 0.9749
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Plasmodium falciparum calcium-dependent protein kinase 7 0.007 0.0098 0.9749
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0055 0.0057 0.0062
Loa Loa (eye worm) hypothetical protein 0.0222 0.0511 0.0505
Brugia malayi Regulator of G protein signaling domain containing protein 0.0602 0.1543 0.1538
Echinococcus granulosus beta-adrenergic receptor kinase 0.2847 0.7643 0.9139
Onchocerca volvulus 0.0222 0.0511 0.3864
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Brugia malayi Sema domain containing protein 0.0222 0.0511 0.0505
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0055 0.0057 0.3626
Entamoeba histolytica PH domain containing protein kinase, putative 0.007 0.0098 0.0428
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0009 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0057 0.0352
Entamoeba histolytica PH domain containing protein kinase, putative 0.007 0.0098 0.0428
Plasmodium falciparum oxysterol-binding protein, putative 0.0055 0.0057 0.3626
Onchocerca volvulus 0.0519 0.1318 1
Trypanosoma cruzi PH domain containing protein, putative 0.0055 0.0057 0.3626
Echinococcus multilocularis oxysterol binding protein 9 0.0055 0.0057 0.0062
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0055 0.0057 0.0051
Schistosoma mansoni protein kinase 0.0046 0.0033 0.0033
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0055 0.0057 0.0051
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Echinococcus multilocularis expressed protein 0.0602 0.1543 0.184
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.007 0.0098 0.9749
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0097 0.0171 0.1095
Trichomonas vaginalis AGC family protein kinase 0.007 0.0098 0.0616
Echinococcus multilocularis cytohesin 1 0.0055 0.0057 0.0062
Brugia malayi PH domain containing protein 0.0055 0.0057 0.0051
Schistosoma mansoni goodpasture antigen-binding protein 0.0055 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0055 0.0057 0.0057
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0055 0.0057 0.3626
Brugia malayi DNA-binding protein LAG-1 0.0097 0.0171 0.0165
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0602 0.1543 0.1543
Trichomonas vaginalis protein transport protein sec7, putative 0.0055 0.0057 0.0352
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0602 0.1543 0.1543
Schistosoma mansoni hypothetical protein 0.0097 0.0171 0.0171
Schistosoma mansoni cell adhesion molecule 0.0037 0.0006 0.0006

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 57.98 uM Inhibition of Enterobacter cloacae P99 beta-lactamase AmpC P99 using nitrocefin as substrate after 30 mins by spectrophotometric analysis ChEMBL. 21392987

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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