TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 452.591 | Formula: C29H32N4O
H donors: 1 H acceptors: 2 LogP: 4.84 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)Nc1cccc(c1)C1CCN(CC1)CCCn1c(nc2c1cccc2)c1ccccc1
InChi: 1S/C29H32N4O/c1-22(34)30-26-12-7-11-25(21-26)23-15-19-32(20-16-23)17-8-18-33-28-14-6-5-13-27(28)31-29(33)24-9-3-2-4-10-24/h2-7,9-14,21,23H,8,15-20H2,1H3,(H,30,34)
InChiKey: MJQUPICMGWTPHB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	melanin-concentrating hormone receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	kinesin light chain, putative	0.0053	0.0052	0.0337
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0068	0.0093	0.0542
Echinococcus granulosus	integrin linked protein kinase	0.0038	0.001	0.0003
Loa Loa (eye worm)	TK/ROR protein kinase	0.0038	0.001	0.0003
Trichomonas vaginalis	protein transport protein sec7, putative	0.0053	0.0052	0.0337
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.001	0.0003
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0112	0.0219	0.1423
Echinococcus granulosus	oxysterol binding protein 1	0.0053	0.0052	0.0054
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.058	0.1539	1
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Entamoeba histolytica	protein kinase, putative	0.0068	0.0093	0.0542
Schistosoma mansoni	hypothetical protein	0.0256	0.0626	0.0617
Trichomonas vaginalis	centaurin alpha, putative	0.0053	0.0052	0.0337
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0068	0.0093	0.9068
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Trypanosoma cruzi	hypothetical protein	0.0053	0.0052	0.4617
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0053	0.0052	0.0311
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0038	0.001	0.0003
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0068	0.0093	0.9068
Echinococcus multilocularis	regulator of G protein signaling	0.058	0.1539	0.1834
Plasmodium vivax	hypothetical protein, conserved	0.0053	0.0052	0.4617
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Brugia malayi	Sema domain containing protein	0.0256	0.0626	0.062
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0068	0.0093	0.9068
Loa Loa (eye worm)	hypothetical protein	0.058	0.1539	0.1533
Echinococcus multilocularis	tyrosine kinase	0.0038	0.001	0.0003
Echinococcus multilocularis	tyrosine protein kinase csk	0.0038	0.001	0.0003
Schistosoma mansoni	regulator of G protein signaling	0.058	0.1539	0.1531
Echinococcus granulosus	tyrosine kinase	0.0038	0.001	0.0003
Echinococcus granulosus	epidermal growth factor receptor	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Echinococcus granulosus	Regulator of G protein signaling 20	0.058	0.1539	0.1834
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0062	0.0078	0.0085
Entamoeba histolytica	protein kinase, putative	0.0068	0.0093	0.0542
Trichomonas vaginalis	TK family protein kinase	0.0038	0.001	0.0063
Loa Loa (eye worm)	AUR protein kinase	0.0071	0.0101	0.0094
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0053	0.0052	0.0054
Echinococcus multilocularis	pdz domain containing protein	0.0053	0.0052	0.0054
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0038	0.001	0.0003
Echinococcus multilocularis	dynamin 1	0.0053	0.0052	0.0054
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Plasmodium vivax	PH domain containing protein	0.0053	0.0052	0.4617
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0052	0.0045
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0053	0.0052	0.0276
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Plasmodium falciparum	PH domain-containing protein, putative	0.0053	0.0052	0.4617
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0038	0.001	0.0003
Schistosoma mansoni	hypothetical protein	0.0112	0.0219	0.021
Schistosoma mansoni	regulator of G protein signaling	0.058	0.1539	0.1531
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0053	0.0052	0.4617
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Trichomonas vaginalis	conserved hypothetical protein	0.058	0.1539	1
Schistosoma mansoni	goodpasture antigen-binding protein	0.0053	0.0052	0.0042
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Brugia malayi	integrin-linked kinase	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.058	0.1539	0.1834
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0053	0.0052	0.4617
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0038	0.001	0.0003
Loa Loa (eye worm)	oxysterol binding protein	0.0053	0.0052	0.0045
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Echinococcus granulosus	axis inhibition protein axin	0.058	0.1539	0.1834
Onchocerca volvulus		0.0038	0.001	0.0047
Loa Loa (eye worm)	TK protein kinase	0.0038	0.001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0626	0.062
Loa Loa (eye worm)	hypothetical protein	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Brugia malayi	Raf kinase	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Schistosoma mansoni	hypothetical protein	0.0053	0.0052	0.0042
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0038	0.001	0.0003
Echinococcus granulosus	tyrosine protein kinase shark	0.0038	0.001	0.0003
Echinococcus granulosus	aurora kinase A	0.0071	0.0101	0.0113
Echinococcus granulosus	activated cdc42 kinase 1	0.0038	0.001	0.0003
Schistosoma mansoni	hypothetical protein	0.0053	0.0052	0.0042
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0053	0.0052	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0078	0.0071
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0038	0.001	0.0003
Schistosoma mansoni	hypothetical protein	0.0053	0.0052	0.0042
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0053	0.0052	0.4617
Giardia lamblia	Aurora kinase	0.0071	0.0101	1
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Echinococcus granulosus	transcription factor collier	0.0112	0.0219	0.0254
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0053	0.005	0.0052
Brugia malayi	PH domain containing protein	0.0053	0.0052	0.0045
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0038	0.001	0.0003
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0038	0.001	0.0003
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Brugia malayi	serine/threonine-protein kinase 6	0.0071	0.0101	0.0094
Schistosoma mansoni	oxysterol-binding protein 1	0.0053	0.0052	0.0042
Brugia malayi	Dynamin	0.0053	0.0052	0.0045
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0053	0.0052	0.0045
Echinococcus multilocularis	actin binding protein anillin	0.0053	0.0052	0.0054
Schistosoma mansoni	voltage-gated potassium channel	0.0041	0.0017	0.0007
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0053	0.0052	0.0276
Echinococcus granulosus	pleckstrin y domain containing family A	0.0053	0.0052	0.0054
Schistosoma mansoni	z-protein (S1r protein)	0.058	0.1539	0.1531
Schistosoma mansoni	hypothetical protein	0.0345	0.0875	0.0866
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0068	0.0093	0.0542
Loa Loa (eye worm)	TK/ALK protein kinase	0.0296	0.0739	0.0732
Loa Loa (eye worm)	sema domain-containing protein	0.0256	0.0626	0.062
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.2161	0.6005	0.7178
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0038	0.001	0.0003
Loa Loa (eye worm)	TK protein kinase	0.0038	0.001	0.0003
Brugia malayi	PXA domain containing protein	0.058	0.1539	0.1533
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0053	0.005	0.4451
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Entamoeba histolytica	hypothetical protein	0.058	0.1539	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0038	0.001	0.0003
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Echinococcus granulosus	oxysterol binding protein 9	0.0053	0.0052	0.0054
Brugia malayi	IPT/TIG domain containing protein	0.0112	0.0219	0.0212
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0053	0.0052	0.0054
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0038	0.001	0.0003
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0038	0.001	0.0063
Brugia malayi	Variant SH3 domain containing protein	0.0053	0.0052	0.0045
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0038	0.001	0.0003
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0053	0.0052	0.0045
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0052	0.0045
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Echinococcus multilocularis	axis inhibition protein axin	0.058	0.1539	0.1834
Entamoeba histolytica	protein kinase, putative	0.0068	0.0093	0.0542
Echinococcus granulosus	regulator of G protein signaling 3	0.058	0.1539	0.1834
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.0219	0.1423
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0052	0.0045
Trypanosoma brucei	protein kinase, putative	0.0053	0.005	0.4451
Loa Loa (eye worm)	plexin A	0.0714	0.1917	0.1911
Echinococcus granulosus	tyrosine protein kinase Blk	0.0038	0.001	0.0003
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0038	0.001	0.0003
Leishmania major	protein kinase, putative	0.0071	0.0101	1
Echinococcus granulosus	Pleckstrin y	0.0053	0.0052	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0038	0.001	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.001	0.0063
Echinococcus multilocularis	semaphorin 5B	0.0256	0.0626	0.0741
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0068	0.0093	0.0542
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0053	0.0052	0.0276
Echinococcus granulosus	Pleckstrin y	0.0053	0.0052	0.0054
Brugia malayi	regulator of G-protein signaling rgs-7	0.058	0.1539	0.1533
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0626	0.062
Trichomonas vaginalis	conserved hypothetical protein	0.058	0.1539	1
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0071	0.0101	0.0598
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0062	0.0078	0.0085
Brugia malayi	Protein kinase domain containing protein	0.0296	0.0739	0.0732
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0053	0.0052	0.0042
Entamoeba histolytica	PH domain containing protein	0.0053	0.0052	0.0276
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0053	0.0052	0.0054
Schistosoma mansoni	serine/threonine protein kinase	0.2741	0.7642	0.764
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0052	0.0045
Echinococcus multilocularis	Regulator of G protein signaling 20	0.058	0.1539	0.1834
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Entamoeba histolytica	PH domain containing protein	0.0053	0.0052	0.0276
Echinococcus multilocularis	protein kinase	0.0038	0.001	0.0003
Trypanosoma cruzi	Protein kinase B	0.0068	0.0093	0.9068
Echinococcus multilocularis	FL cytokine receptor	0.0038	0.001	0.0003
Entamoeba histolytica	hypothetical protein	0.0053	0.0052	0.0276
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.0101	0.0091
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.001	0.0063
Echinococcus granulosus	expressed protein	0.058	0.1539	0.1834
Entamoeba histolytica	hypothetical protein, conserved	0.0053	0.0052	0.0276
Schistosoma mansoni	axis inhibition protein axin	0.058	0.1539	0.1531
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Schistosoma mansoni	serine/threonine-protein kinase	0.0068	0.0093	0.0083
Echinococcus granulosus	c src tyrosine kinase	0.0038	0.001	0.0003
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0068	0.0093	0.9068
Trichomonas vaginalis	centaurin/arf, putative	0.0053	0.0052	0.0337
Trypanosoma cruzi	PH domain containing protein, putative	0.0053	0.0052	0.4617
Plasmodium falciparum	oxysterol-binding protein, putative	0.0053	0.0052	0.4617
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.2741	0.7642	0.7641
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0043	0.0023	0.0019
Trichomonas vaginalis	conserved hypothetical protein	0.058	0.1539	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0038	0.001	0.0003
Onchocerca volvulus		0.0038	0.001	0.0047
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0038	0.001	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0038	0.001	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0052	0.0337
Echinococcus granulosus	semaphorin 1A	0.0256	0.0626	0.0741
Brugia malayi	Probable exocyst complex component Sec5	0.0112	0.0219	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0052	0.0045
Onchocerca volvulus		0.0038	0.001	0.0047
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0038	0.001	0.0003
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Loa Loa (eye worm)	AUR protein kinase	0.0071	0.0101	0.0094
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Entamoeba histolytica	hypothetical protein	0.058	0.1539	1
Loa Loa (eye worm)	hypothetical protein	0.0345	0.0875	0.0869
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0038	0.001	0.0003
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0053	0.0052	0.0054
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Entamoeba histolytica	hypothetical protein	0.0068	0.0093	0.0542
Brugia malayi	Plexin repeat family protein	0.0601	0.1599	0.1594
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0038	0.001	0.0047
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0053	0.0052	0.0045
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Trypanosoma cruzi	aurora B kinase, putative	0.0071	0.0101	1
Toxoplasma gondii	hypothetical protein	0.0053	0.0052	0.4617
Toxoplasma gondii	hypothetical protein	0.0053	0.0052	0.4617
Loa Loa (eye worm)	hypothetical protein	0.0227	0.0543	0.0537
Schistosoma mansoni	zinc finger protein	0.0053	0.0052	0.0042
Echinococcus multilocularis	regulator of G protein signaling 7	0.058	0.1539	0.1834
Onchocerca volvulus		0.0038	0.001	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0052	0.0045
Onchocerca volvulus	Putative zinc finger protein	0.0053	0.0052	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0626	0.062
Entamoeba histolytica	protein kinase, putative	0.0068	0.0093	0.0542
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0038	0.001	0.0003
Brugia malayi	Furin-like cysteine rich region family protein	0.0038	0.001	0.0003
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Onchocerca volvulus		0.0038	0.001	0.0047
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0068	0.0093	0.0602
Schistosoma mansoni	centaurin alpha	0.0053	0.0052	0.0042
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0053	0.0052	0.0054
Loa Loa (eye worm)	hypothetical protein	0.058	0.1539	0.1533
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.0219	0.1423
Loa Loa (eye worm)	hypothetical protein	0.058	0.1539	0.1533
Echinococcus granulosus	tyrosine protein kinase HCK	0.0038	0.001	0.0003
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0068	0.0093	0.9068
Brugia malayi	TBC domain containing protein	0.0053	0.0052	0.0045
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0053	0.005	0.0052
Brugia malayi	SRC-1	0.0038	0.001	0.0003
Entamoeba histolytica	protein kinase, putative	0.0071	0.0101	0.0598
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0038	0.001	0.0003
Echinococcus granulosus	exocyst complex component 2	0.0112	0.0219	0.0254
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.001	0.0063
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0068	0.0093	0.0602
Schistosoma mansoni	oxysterol-binding protein 1	0.0053	0.0052	0.0042
Brugia malayi	hypothetical protein	0.0038	0.001	0.0003
Schistosoma mansoni	growth factor receptor-bound protein	0.0053	0.0052	0.0042
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0053	0.0052	0.0054
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0053	0.0052	0.4617
Onchocerca volvulus		0.0053	0.0052	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0052	0.0045
Trypanosoma brucei	protein kinase, putative	0.0068	0.0093	0.9068
Loa Loa (eye worm)	PXA domain-containing protein	0.058	0.1539	0.1533
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0112	0.0219	0.1423
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0068	0.0093	0.9068
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Echinococcus granulosus	tyrosine kinase	0.0038	0.001	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.001	0.0063
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0038	0.001	0.0003
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Brugia malayi	PH domain containing protein	0.0053	0.0052	0.0045
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0053	0.0052	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0038	0.001	0.0003
Echinococcus granulosus	axis inhibition protein axin	0.058	0.1539	0.1834
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.001	0.0003
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0053	0.0052	0.4617
Trichomonas vaginalis	conserved hypothetical protein	0.058	0.1539	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0038	0.001	0.0003
Echinococcus granulosus	tyrosine protein kinase Srms	0.0038	0.001	0.0003
Echinococcus multilocularis	regulator of G protein signaling 7	0.058	0.1539	0.1834
Loa Loa (eye worm)	TK protein kinase	0.0038	0.001	0.0003
Echinococcus granulosus	natriuretic peptide receptor 1	0.0038	0.001	0.0003
Echinococcus granulosus	myotubularin protein 13	0.0053	0.0052	0.0054
Onchocerca volvulus		0.0256	0.0626	0.3905
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0053	0.005	0.4451
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0038	0.001	0.0003
Entamoeba histolytica	protein kinase, putative	0.0068	0.0093	0.0542
Loa Loa (eye worm)	hypothetical protein	0.058	0.1539	0.1533
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0068	0.0093	0.0542
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.0219	0.1423
Echinococcus multilocularis	plexin a4	0.0714	0.1917	0.2286
Echinococcus granulosus	ephrin type A receptor 4 A	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Brugia malayi	PH domain containing protein	0.0053	0.0052	0.0045
Onchocerca volvulus		0.0053	0.0052	0.0311
Onchocerca volvulus		0.0601	0.1599	1
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0112	0.0219	0.1423
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0068	0.0093	0.9068
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0078	0.0071
Echinococcus multilocularis	tyrosine protein kinase	0.0038	0.001	0.0003
Brugia malayi	hypothetical protein	0.058	0.1539	0.1533
Loa Loa (eye worm)	TK protein kinase	0.0038	0.001	0.0003
Schistosoma mansoni	voltage-gated potassium channel	0.0041	0.0017	0.0007
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.2996	0.8363	0.8362
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Echinococcus granulosus	protein tyrosine kinase	0.0038	0.001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0052	0.0045
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0038	0.001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0091	0.0084
Echinococcus multilocularis	exocyst complex component 2	0.0112	0.0219	0.0254
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0053	0.0052	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0052	0.0045
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0053	0.0052	0.4617
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0038	0.001	0.0003
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0053	0.0052	0.0276
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0038	0.001	0.0003
Brugia malayi	hypothetical protein	0.0256	0.0626	0.062
Echinococcus granulosus	regulator of G protein signaling 7	0.058	0.1539	0.1834
Brugia malayi	Syntrophin-1	0.0053	0.0052	0.0045
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Schistosoma mansoni	hypothetical protein	0.0053	0.0052	0.0042
Loa Loa (eye worm)	uncoordinated protein 104	0.0053	0.0052	0.0045
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.058	0.1539	0.1533
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0038	0.001	0.0003
Echinococcus granulosus	defective proboscis extension response	0.0062	0.0078	0.0085
Echinococcus multilocularis	aurora kinase A	0.0071	0.0101	0.0113
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0053	0.0052	0.0276
Loa Loa (eye worm)	TK/INSR protein kinase	0.0038	0.001	0.0003
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0071	0.0101	0.0598
Echinococcus granulosus	oxysterol binding protein 3	0.0053	0.0052	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0091	0.0084
Loa Loa (eye worm)	TK/ACK protein kinase	0.0038	0.001	0.0003
Brugia malayi	Sema domain containing protein	0.0256	0.0626	0.062
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0053	0.0052	0.0054
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0038	0.001	0.0003
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Schistosoma mansoni	protein kinase	0.0053	0.005	0.0041
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0038	0.001	0.0003
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.001	0.0003
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0112	0.0219	0.1423
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0052	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0219	0.0212
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0038	0.001	0.0003
Schistosoma mansoni	plexin	0.0345	0.0875	0.0866
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0038	0.001	0.0003
Echinococcus granulosus	plexin a4	0.0714	0.1917	0.2286
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0052	0.0337
Echinococcus granulosus	serine/threonine protein kinase	0.0068	0.0093	0.0103
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Brugia malayi	Tyrosine-protein kinase abl-1	0.0038	0.001	0.0003
Trichomonas vaginalis	protein transport protein sec7, putative	0.0053	0.0052	0.0337
Leishmania major	hypothetical protein, conserved	0.0053	0.0052	0.4617
Brugia malayi	Uncoordinated protein 104	0.0053	0.0052	0.0045
Echinococcus granulosus	DCC interacting protein 13 beta	0.0053	0.0052	0.0054
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0053	0.0052	0.0045
Trichomonas vaginalis	STE family protein kinase	0.0038	0.001	0.0063
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0067	0.0091	0.0084
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0053	0.0052	0.0337
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0071	0.0101	0.0113
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0038	0.001	0.0003
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0053	0.0052	0.0045
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0052	0.0337
Echinococcus granulosus	activin receptor type	0.0053	0.005	0.0052
Trichomonas vaginalis	centaurin gamma, putative	0.0053	0.0052	0.0337
Brugia malayi	A-kinase anchor protein 10, precursor	0.058	0.1539	0.1533
Loa Loa (eye worm)	hypothetical protein	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Brugia malayi	PXA domain containing protein	0.058	0.1539	0.1533
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0053	0.0052	0.0054
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0053	0.0052	0.0054
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0068	0.0093	0.0542
Schistosoma mansoni	vav2	0.0053	0.0052	0.0042
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0038	0.001	0.0047
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0038	0.001	0.0003
Loa Loa (eye worm)	sema domain-containing protein	0.0256	0.0626	0.062
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0101	0.0657
Echinococcus multilocularis	transfer RNA-Thr	0.0038	0.001	0.0003
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0038	0.001	0.0063
Echinococcus multilocularis	Oxysterol binding protein 11	0.0053	0.0052	0.0054
Loa Loa (eye worm)	TK/ABL protein kinase	0.0038	0.001	0.0003
Loa Loa (eye worm)	TK protein kinase	0.0038	0.001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0052	0.0045
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0053	0.0052	0.0276
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0068	0.0093	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0052	0.0045
Entamoeba histolytica	hypothetical protein	0.0053	0.0052	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0626	0.062
Echinococcus granulosus	cytohesin 1	0.0053	0.0052	0.0054
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Echinococcus multilocularis	oxysterol binding protein 1	0.0053	0.0052	0.0054
Echinococcus granulosus	Pleckstrin y	0.0053	0.0052	0.0054
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0052	0.0337
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.001	0.0063
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.2996	0.8363	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0038	0.001	0.0003
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0068	0.0093	0.9068
Schistosoma mansoni	dynamin	0.0053	0.0052	0.0042
Echinococcus granulosus	Immunoglobulin	0.0062	0.0078	0.0085
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0038	0.001	0.0003
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0053	0.0052	0.0311
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Echinococcus multilocularis	transcription factor collier	0.0112	0.0219	0.0254
Loa Loa (eye worm)	RGS-3 protein	0.058	0.1539	0.1533
Brugia malayi	Receptor family ligand binding region containing protein	0.0038	0.001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0052	0.0045
Entamoeba histolytica	hypothetical protein	0.0112	0.0219	0.1369
Loa Loa (eye worm)	hypothetical protein	0.0038	0.001	0.0003
Entamoeba histolytica	hypothetical protein	0.0053	0.0052	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0052	0.0045
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0068	0.0093	0.9068
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0038	0.001	0.0003
Brugia malayi	PH domain containing protein	0.0053	0.0052	0.0045
Schistosoma mansoni	protein kinase	0.0053	0.005	0.0041
Schistosoma mansoni	regulator of G protein signaling	0.058	0.1539	0.1531
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Trypanosoma cruzi	hypothetical protein	0.0053	0.0052	0.4617
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0038	0.001	0.0003
Echinococcus multilocularis	rac serine:threonine kinase	0.0068	0.0093	0.0103
Trypanosoma cruzi	PH domain containing protein, putative	0.0053	0.0052	0.4617
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Loa Loa (eye worm)	TK protein kinase	0.0038	0.001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0038	0.001	0.0003
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0053	0.0052	0.0054
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.0219	0.1423
Schistosoma mansoni	dynamin	0.0053	0.0052	0.0042
Echinococcus granulosus	regulator of G protein signaling 7	0.058	0.1539	0.1834
Plasmodium falciparum	protein kinase, putative	0.0053	0.005	0.4451
Echinococcus multilocularis	myotubularin protein 13	0.0053	0.0052	0.0054
Echinococcus multilocularis	activin receptor type	0.0053	0.005	0.0052
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0062	0.0078	0.0068
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.001	0.0003
Entamoeba histolytica	p21-activated kinase	0.0068	0.0093	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0078	0.0071
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0052	0.0337
Onchocerca volvulus		0.0038	0.001	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0038	0.001	0.0003
Echinococcus multilocularis	regulator of G protein signaling 3	0.058	0.1539	0.1834
Schistosoma mansoni	cell adhesion molecule	0.0067	0.0091	0.0082
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0068	0.0093	0.9068
Trichomonas vaginalis	protein kinase atn1, putative	0.0038	0.001	0.0063
Echinococcus multilocularis	epidermal growth factor receptor	0.0038	0.001	0.0003
Schistosoma mansoni	semaphorin 5-related	0.0256	0.0626	0.0617
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0038	0.001	0.0003
Echinococcus multilocularis	axis inhibition protein axin	0.058	0.1539	0.1834
Schistosoma mansoni	regulator of G protein signaling	0.058	0.1539	0.1531
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Echinococcus granulosus	semaphorin 5B	0.0256	0.0626	0.0741
Trichomonas vaginalis	conserved hypothetical protein	0.058	0.1539	1
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0071	0.0101	0.0598
Brugia malayi	hypothetical protein	0.0256	0.0626	0.062
Onchocerca volvulus		0.0038	0.001	0.0047
Echinococcus multilocularis	Immunoglobulin	0.0062	0.0078	0.0085
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0068	0.0093	0.9068
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0219	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0219	0.0212
Brugia malayi	probable spectrin beta chain	0.0053	0.0052	0.0045
Entamoeba histolytica	protein kinase, putative	0.0068	0.0093	0.0542
Brugia malayi	hypothetical protein	0.0038	0.001	0.0003
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0038	0.001	0.0003
Loa Loa (eye worm)	Plekhf2 protein	0.0053	0.0052	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0078	0.0071
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0053	0.0052	0.0276
Entamoeba histolytica	tyrosin kinase, putative	0.0151	0.0327	0.2075
Brugia malayi	Cytohesin 3	0.0053	0.0052	0.0045
Loa Loa (eye worm)	hypothetical protein	0.058	0.1539	0.1533
Brugia malayi	plexin A	0.0714	0.1917	0.1911
Schistosoma mansoni	rho gtpase activating protein	0.0053	0.0052	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0052	0.0045
Brugia malayi	Guanylyl cyclase protein 23	0.0038	0.001	0.0003
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.2996	0.8363	0.8362
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0052	0.0337
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0053	0.005	0.4451
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.2996	0.8363	1
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0068	0.0093	0.9068
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Onchocerca volvulus	Tyrosine kinase homolog	0.0038	0.001	0.0047
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0053	0.0052	0.0054
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Onchocerca volvulus		0.0038	0.001	0.0047
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0038	0.001	0.0003
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0071	0.0101	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0068	0.0093	0.9068
Trypanosoma cruzi	PH domain containing protein, putative	0.0053	0.0052	0.4617
Echinococcus granulosus	calcium dependent secretion activator 1	0.0053	0.0052	0.0054
Brugia malayi	Tyrosine-protein kinase PR2	0.0038	0.001	0.0003
Echinococcus multilocularis	roundabout 2	0.0067	0.0091	0.0101
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0038	0.001	0.0003
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0101	0.0186	0.0179
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0038	0.001	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0052	0.0337
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0038	0.001	0.0003
Echinococcus multilocularis	tyrosine protein kinase shark	0.0038	0.001	0.0003
Schistosoma mansoni	plexin	0.0601	0.1599	0.1591
Onchocerca volvulus		0.0038	0.001	0.0047
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0071	0.0101	1
Trypanosoma cruzi	hypothetical protein	0.0053	0.0052	0.4617
Entamoeba histolytica	cell surface protease gp63, putative	0.0112	0.0219	0.1369
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0038	0.001	0.0003
Loa Loa (eye worm)	TK protein kinase	0.0038	0.001	0.0003
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0038	0.001	0.0003
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0038	0.001	0.0003
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0053	0.0052	0.0054
Trypanosoma brucei	PH domain containing protein, putative	0.0053	0.0052	0.4617
Echinococcus granulosus	kinase suppressor of Ras 1	0.0038	0.001	0.0003
Brugia malayi	Regulator of G protein signaling domain containing protein	0.058	0.1539	0.1533
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Loa Loa (eye worm)	TK/CSK protein kinase	0.0038	0.001	0.0003
Echinococcus multilocularis	oxysterol binding protein 3	0.0053	0.0052	0.0054
Brugia malayi	Oxysterol-binding protein	0.0053	0.0052	0.0045
Schistosoma mansoni	axis inhibition protein axin	0.058	0.1539	0.1531
Loa Loa (eye worm)	hypothetical protein	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Brugia malayi	serine/threonine kinase 12	0.0071	0.0101	0.0094
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Echinococcus granulosus	roundabout 2	0.0067	0.0091	0.0101
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0053	0.0052	0.0276
Echinococcus multilocularis	cytohesin 1	0.0053	0.0052	0.0054
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0068	0.0093	0.0542
Echinococcus granulosus	dynamin 1	0.0053	0.0052	0.0054
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0052	0.0337
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0053	0.0052	0.0054
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.0219	0.1423
Echinococcus granulosus	tyrosine protein kinase csk	0.0038	0.001	0.0003
Echinococcus multilocularis	oxysterol binding protein 9	0.0053	0.0052	0.0054
Entamoeba histolytica	hypothetical protein	0.0112	0.0219	0.1369
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Trichomonas vaginalis	AGC family protein kinase	0.0038	0.001	0.0063
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0053	0.0052	0.4617
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0101	0.0657
Onchocerca volvulus		0.0038	0.001	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0091	0.0084
Trichomonas vaginalis	centaurin beta, putative	0.0053	0.0052	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0219	0.0212
Echinococcus granulosus	tyrosine protein kinase	0.0038	0.001	0.0003
Brugia malayi	C-terminal src kinase protein 1	0.0038	0.001	0.0003
Echinococcus granulosus	GRB2 associated binding protein 3	0.0053	0.0052	0.0054
Brugia malayi	Oxysterol binding protein	0.0053	0.0052	0.0045
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Loa Loa (eye worm)	TK/RYK protein kinase	0.0038	0.001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0038	0.001	0.0003
Leishmania major	protein kinase, putative	0.0068	0.0093	0.9068
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0053	0.0052	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0078	0.0071
Trypanosoma cruzi	hypothetical protein	0.0053	0.0052	0.4617
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0038	0.001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.058	0.1539	0.1533
Leishmania major	protein kinase, putative	0.0068	0.0093	0.9068
Echinococcus granulosus	beta-adrenergic receptor kinase	0.2741	0.7642	0.9138
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0038	0.001	0.0003
Brugia malayi	DNA-binding protein LAG-1	0.0112	0.0219	0.0212
Loa Loa (eye worm)	TK/EPH protein kinase	0.0038	0.001	0.0003
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.058	0.1539	0.1834
Onchocerca volvulus		0.0053	0.0052	0.0311
Brugia malayi	serine/threonine protein kinase 6	0.0071	0.0101	0.0094
Loa Loa (eye worm)	syntrophin-1	0.0053	0.0052	0.0045
Echinococcus multilocularis	activated cdc42 kinase 1	0.0038	0.001	0.0003
Entamoeba histolytica	hypothetical protein	0.0112	0.0219	0.1369
Trichomonas vaginalis	centaurin/arf, putative	0.0053	0.0052	0.0337
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0038	0.001	0.0003
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0038	0.001	0.0003
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0068	0.0093	0.9068
Trypanosoma brucei	aurora B kinase	0.0071	0.0101	1
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0052	0.0337
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0068	0.0093	0.9068
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0068	0.0093	0.9068
Echinococcus multilocularis	Pleckstrin y	0.0053	0.0052	0.0054
Echinococcus multilocularis	integrin linked protein kinase	0.0038	0.001	0.0003
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0053	0.0052	0.0276
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0052	0.0337
Entamoeba histolytica	protein kinase, putative	0.0071	0.0101	0.0598
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0038	0.001	0.0003
Echinococcus granulosus	activated cdc42 kinase 1	0.0038	0.001	0.0003
Schistosoma mansoni	hypothetical protein	0.0053	0.0052	0.0042
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0043	0.0023	0.0019
Schistosoma mansoni	serine/threonine protein kinase	0.2741	0.7642	0.764
Onchocerca volvulus		0.0038	0.001	0.0047
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0038	0.001	0.0003
Echinococcus multilocularis	tyrosine protein kinase csk	0.0038	0.001	0.0003
Schistosoma mansoni	regulator of G protein signaling	0.058	0.1539	0.1531
Brugia malayi	PH domain containing protein	0.0053	0.0052	0.0045
Onchocerca volvulus		0.0053	0.0052	0.0311
Echinococcus granulosus	epidermal growth factor receptor	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0068	0.0093	0.9068
Schistosoma mansoni	zinc finger protein	0.0053	0.0052	0.0042
Echinococcus multilocularis	insulin receptor	0.0038	0.001	0.0003
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.001	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.058	0.1539	1
Trypanosoma cruzi	hypothetical protein	0.0053	0.0052	0.4617
Brugia malayi	Fibronectin type III domain containing protein	0.0067	0.0091	0.0084
Loa Loa (eye worm)	rho-GTPase-activating	0.0053	0.0052	0.0045
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0068	0.0093	0.9068
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0052	0.0045
Echinococcus multilocularis	protein kinase	0.0038	0.001	0.0003
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Loa Loa (eye worm)	cytohesin 3	0.0053	0.0052	0.0045
Echinococcus granulosus	regulator of G protein signaling 3	0.058	0.1539	0.1834
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0053	0.0052	0.0276
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0053	0.0052	0.0054
Echinococcus multilocularis	beta adrenergic receptor kinase	0.2741	0.7642	0.9138
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0038	0.001	0.0003
Brugia malayi	PH domain containing protein	0.0053	0.0052	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0052	0.0045
Onchocerca volvulus		0.0038	0.001	0.0047
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.001	0.0003
Brugia malayi	PH domain containing protein	0.0053	0.0052	0.0045
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Echinococcus multilocularis	expressed protein	0.058	0.1539	0.1834
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Toxoplasma gondii	aurora kinase	0.0071	0.0101	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0053	0.005	0.0052
Onchocerca volvulus		0.0038	0.001	0.0047
Loa Loa (eye worm)	PH domain-containing protein	0.0053	0.0052	0.0045
Onchocerca volvulus		0.0038	0.001	0.0047
Trichomonas vaginalis	hypothetical protein	0.0053	0.0052	0.0337
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0093	0.0086
Loa Loa (eye worm)	serine/threonine protein kinase	0.0038	0.001	0.0003
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0053	0.0052	0.0054
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0038	0.001	0.0003
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0053	0.0052	0.0045
Leishmania major	protein kinase, putative	0.0053	0.005	0.4451
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0038	0.001	0.0003
Onchocerca volvulus		0.0053	0.0052	0.0311
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.001	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0052	0.0337
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0053	0.0052	0.0054
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0.005	0.0266
Toxoplasma gondii	AtPH1 family protein	0.0053	0.0052	0.4617
Echinococcus granulosus	pdz domain containing protein	0.0053	0.0052	0.0054
Schistosoma mansoni	goodpasture antigen-binding protein	0.0053	0.0052	0.0042
Echinococcus granulosus	insulin receptor	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Trypanosoma cruzi	hypothetical protein	0.0053	0.0052	0.4617
Schistosoma mansoni	hypothetical protein	0.0256	0.0626	0.0617
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0052	0.0337
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0038	0.001	0.0003
Brugia malayi	PH domain containing protein	0.0053	0.0052	0.0045
Echinococcus granulosus	receptor type guanylyl cyclase	0.0038	0.001	0.0003
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0038	0.001	0.0003
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0038	0.001	0.0003
Loa Loa (eye worm)	TK/FAK protein kinase	0.0038	0.001	0.0003
Trypanosoma cruzi	NIMA-related kinase, putative	0.0068	0.0093	0.9068
Loa Loa (eye worm)	SRC-1	0.0038	0.001	0.0003
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Echinococcus multilocularis	epidermal growth factor receptor	0.0038	0.001	0.0003
Entamoeba histolytica	protein kinase , putative	0.0071	0.0101	0.0598
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0038	0.001	0.0003
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0601	0.1599	0.1594
Onchocerca volvulus		0.0053	0.0052	0.0311
Brugia malayi	protein-tyrosine kinase	0.0038	0.001	0.0003
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0038	0.001	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0052	0.0337
Loa Loa (eye worm)	TK/DDR protein kinase	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0038	0.001	0.0063
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Echinococcus granulosus	raf serine:threonine protein kinase	0.0038	0.001	0.0003
Leishmania major	hypothetical protein, conserved	0.0053	0.0052	0.4617
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0053	0.0052	0.4617
Schistosoma mansoni	vesicular amine transporter	0.0065	0.0085	0.0075
Loa Loa (eye worm)	TK protein kinase	0.0038	0.001	0.0003
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0053	0.0052	0.0276
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.001	0.0003
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0038	0.001	0.0003
Onchocerca volvulus		0.0053	0.0052	0.0311
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0071	0.0101	0.0113
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Echinococcus multilocularis	tyrosine protein kinase csk	0.0038	0.001	0.0003
Leishmania major	serine/threonine-protein kinase a, putative	0.0068	0.0093	0.9068
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0038	0.001	0.0003
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0038	0.001	0.0003
Brugia malayi	Plekhf2 protein	0.0053	0.0052	0.0045
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Trichomonas vaginalis	alpha chimerin, putative	0.0053	0.0052	0.0337
Loa Loa (eye worm)	TK protein kinase	0.0038	0.001	0.0003
Echinococcus multilocularis	c src tyrosine kinase	0.0038	0.001	0.0003
Brugia malayi	ephrin receptor 1 precursor	0.0038	0.001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0038	0.001	0.0003
Entamoeba histolytica	protein kinase domain containing protein	0.0151	0.0327	0.2075
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0053	0.0052	0.0337
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0053	0.0052	0.0276
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.058	0.1539	0.1531
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0626	0.062
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.058	0.1539	0.1531
Echinococcus granulosus	tyrosine kinase	0.0038	0.001	0.0003
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Echinococcus granulosus	beta 1 syntrophin	0.0053	0.0052	0.0054
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.2996	0.8363	0.8362
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0038	0.001	0.0003
Brugia malayi	hypothetical protein	0.0053	0.0052	0.0045
Echinococcus multilocularis	heat shock protein 70	0.0038	0.001	0.0003
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.0112	0.0219	0.1423
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0101	0.0657
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Schistosoma mansoni	myotubularin-related protein	0.0053	0.0052	0.0042
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0068	0.0093	0.9068
Brugia malayi	Regulator of G protein signaling domain containing protein	0.058	0.1539	0.1533
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0053	0.0052	0.4617
Entamoeba histolytica	hypothetical protein	0.0053	0.0052	0.0276
Entamoeba histolytica	PH domain containing protein	0.0053	0.0052	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0052	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0626	0.062
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0062	0.0078	0.0068
Loa Loa (eye worm)	AUR protein kinase	0.0071	0.0101	0.0094
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0038	0.001	0.0003
Echinococcus multilocularis	beta 1 syntrophin	0.0053	0.0052	0.0054
Onchocerca volvulus		0.0038	0.001	0.0047
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.001	0.0003
Echinococcus granulosus	tyrosine protein kinase pr2	0.0038	0.001	0.0003
Toxoplasma gondii	Oxysterol-binding protein	0.0053	0.0052	0.4617
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0053	0.0052	0.0276
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0053	0.0052	0.0337
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0038	0.001	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.0219	0.1423
Echinococcus granulosus	Rho GTPase activating protein 24	0.0053	0.0052	0.0054
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Echinococcus granulosus	neuroglian	0.0062	0.0078	0.0085
Entamoeba histolytica	protein kinase, putative	0.0068	0.0093	0.0542
Brugia malayi	PH domain containing protein	0.0053	0.0052	0.0045
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Trypanosoma cruzi	hypothetical protein	0.0053	0.0052	0.4617
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0053	0.0052	0.0054
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0053	0.0052	0.0042
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0053	0.005	0.4451
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Schistosoma mansoni	ephrin receptor	0.0043	0.0023	0.0013
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.001	0.0003
Entamoeba histolytica	protein kinase domain containing protein	0.0071	0.0101	0.0598
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0053	0.0052	0.0054
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0101	0.0657
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0093	0.0602
Brugia malayi	Dynamin	0.0053	0.0052	0.0045
Leishmania major	folate/biopterin transporter, putative	0.0068	0.0093	0.9068
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.0219	0.1423
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0038	0.001	0.0063
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0101	0.0186	0.0179
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0038	0.001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0052	0.0045
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0038	0.001	0.0003
Schistosoma mansoni	protein kinase	0.0053	0.005	0.0041
Brugia malayi	Pleckstrin Homology Domain	0.0053	0.0052	0.0045
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.001	0.0063
Entamoeba histolytica	hypothetical protein	0.0068	0.0093	0.0542
Brugia malayi	hypothetical protein	0.058	0.1539	0.1533
Onchocerca volvulus	outspread protein homolog	0.0053	0.0052	0.0311
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.001	0.0003
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0053	0.0052	0.0337
Loa Loa (eye worm)	TK protein kinase	0.0038	0.001	0.0003
Schistosoma mansoni	hypothetical protein	0.0112	0.0219	0.021
Echinococcus granulosus	tyrosine protein kinase csk	0.0038	0.001	0.0003
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0038	0.001	0.0003
Echinococcus granulosus	protein kinase	0.0038	0.001	0.0003
Echinococcus multilocularis	regulator of G protein signaling 3	0.058	0.1539	0.1834
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0038	0.001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0078	0.0071
Schistosoma mansoni	fibrocystin l	0.0112	0.0219	0.021
Schistosoma mansoni	serine/threonine-protein kinase	0.0068	0.0093	0.0083
Echinococcus multilocularis	hypothetical protein	0.0256	0.0626	0.0741
Echinococcus granulosus	G protein coupled receptor kinase 1	0.2161	0.6005	0.7178
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0053	0.0052	0.4617
Entamoeba histolytica	hypothetical protein	0.058	0.1539	1
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Brugia malayi	SH2 domain containing protein	0.0038	0.001	0.0003
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0038	0.001	0.0003
Echinococcus multilocularis	Pleckstrin y	0.0053	0.0052	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0052	0.0045
Brugia malayi	SH2 domain containing protein	0.0038	0.001	0.0003
Brugia malayi	hypothetical protein	0.0038	0.001	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0052	0.0337
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0053	0.0052	0.0042
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0052	0.0337
Trypanosoma cruzi	PH domain containing protein, putative	0.0053	0.0052	0.4617
Echinococcus granulosus	twitchin	0.0077	0.0119	0.0134
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0053	0.0052	0.0054
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0038	0.001	0.0003
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.001	0.0003
Brugia malayi	Variant SH3 domain containing protein	0.0053	0.0052	0.0045
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.058	0.1539	0.1531
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0038	0.001	0.0003
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0038	0.001	0.0003
Entamoeba histolytica	hypothetical protein	0.0053	0.0052	0.0276
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0053	0.0052	0.0276
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.001	0.0003
Onchocerca volvulus	Protein melted homolog	0.0053	0.0052	0.0311
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0052	0.0337
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.001	0.0003
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0038	0.001	0.0003
Schistosoma mansoni	protein kinase	0.0071	0.0101	0.0091
Brugia malayi	Cadps2 protein	0.0053	0.0052	0.0045
Echinococcus multilocularis	Pleckstrin y	0.0053	0.0052	0.0054
Echinococcus granulosus	Oxysterol binding protein 11	0.0053	0.0052	0.0054
Echinococcus multilocularis	tyrosine kinase	0.0038	0.001	0.0003
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0053	0.0052	0.0276
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0053	0.0052	0.0042
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0053	0.0052	0.0054
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0052	0.0337
Brugia malayi	regulator of G-protein signaling egl-10	0.058	0.1539	0.1533
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.001	0.0063
Echinococcus multilocularis	Immunoglobulin	0.0062	0.0078	0.0085
Echinococcus multilocularis	tyrosine protein kinase csk	0.0038	0.001	0.0003
Brugia malayi	hypothetical protein	0.0067	0.0091	0.0084
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Brugia malayi	Protein kinase domain containing protein	0.0038	0.001	0.0003
Loa Loa (eye worm)	TK/Met protein kinase	0.0038	0.001	0.0003
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Trichomonas vaginalis	CAMK family protein kinase	0.0038	0.001	0.0063
Echinococcus multilocularis	protein tyrosine kinase	0.0038	0.001	0.0003
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.001	0.0003
Entamoeba histolytica	hypothetical protein	0.0112	0.0219	0.1369
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0053	0.0052	0.0337
Trypanosoma cruzi	NIMA-related kinase, putative	0.0068	0.0093	0.9068
Brugia malayi	MAX-1A	0.0053	0.0052	0.0045
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0038	0.001	0.0003
Echinococcus granulosus	tyrosine protein kinase csk	0.0038	0.001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0038	0.001	0.0003
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0068	0.0093	0.9068
Schistosoma mansoni	syntrophin	0.0053	0.0052	0.0042
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0053	0.0052	0.0276
Echinococcus multilocularis	neuroglian	0.0062	0.0078	0.0085
Trichomonas vaginalis	TKL family protein kinase	0.0038	0.001	0.0063
Schistosoma mansoni	nephrin	0.0067	0.0091	0.0082
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0038	0.001	0.0003

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2 nM	Displacement of Eu-labeled MCH from human MCH-R1 expressed in CHO by time-resolved fluorometric assay	ChEMBL.	21420863

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1761098

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1510194