Detailed information for compound 1511802

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 317.77 | Formula: C16H16ClN3O2
  • H donors: 0 H acceptors: 2 LogP: 2.9 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)COC(c1ccco1)CCn1cncn1
  • InChi: 1S/C16H16ClN3O2/c17-14-4-1-3-13(9-14)10-22-16(15-5-2-8-21-15)6-7-20-12-18-11-19-20/h1-5,8-9,11-12,16H,6-7,10H2
  • InChiKey: CFDZATSTCMVYSC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.0163
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0104 0.0671
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.001 0.0005 0.0036
Brugia malayi Patched family protein 0.0013 0.0018 0.0057
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0179 0.0801 1
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.014 0.0966
Loa Loa (eye worm) hypothetical protein 0.0108 0.0469 0.1774
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.015 0.103
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0003 0.0003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0114 0.0424
Leishmania major DNA polymerase kappa, putative 0.0013 0.0018 0.0123
Onchocerca volvulus 0.0273 0.1242 1
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0103 0.0382
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0022 0.0117
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0075 0.016
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0011 0.0033
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0104 0.127
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0003 0.0003
Brugia malayi indoleamine 2,3-dioxygenase 0.0568 0.2631 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0285 0.1963
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0089 0.0544
Loa Loa (eye worm) DR-78 0.001 0.0006 0.0011
Schistosoma mansoni coup transcription factor 0.0021 0.0058 0.0056
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.0568 0.2631 0.2631
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.0375 0.2893
Brugia malayi hypothetical protein 0.0013 0.0018 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0058 0.0212
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.001
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0104 0.0773
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0058 0.0212
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.015 0.1076
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0148 0.0148
Schistosoma mansoni ap endonuclease 0.0039 0.014 0.0137
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0018 0.0123
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0058 0.0058
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0018 0.016
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0318 0.1453 1
Schistosoma mansoni alpha glucosidase 0.0074 0.0307 0.0305
Chlamydia trachomatis phosphoglycerate kinase 0.0179 0.0801 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0103 0.1257
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0198 0.1361
Echinococcus granulosus lysosomal alpha glucosidase 0.0334 0.153 0.153
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0497 0.5232
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0497 0.1879
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0198 0.0198
Onchocerca volvulus 0.0035 0.0123 0.0972
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.014 0.0464
Mycobacterium ulcerans hypothetical protein 0.0025 0.0075 0.0466
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0179 0.0801 0.5511
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0058 0.0212
Brugia malayi Patched family protein 0.0013 0.0018 0.0057
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0307 0.2337
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0078 0.0078
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0114 0.0114
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0003 0.0003
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0198 0.1361
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0198 0.1361
Brugia malayi PHD-finger family protein 0.0012 0.0014 0.0043
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0179 0.0801 0.3037
Echinococcus granulosus Niemann Pick C1 protein 0.0295 0.1346 0.1346
Echinococcus multilocularis tumor protein p63 0.0388 0.1785 0.1785
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0018 0.0015
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0075 0.0583
Mycobacterium ulcerans lipase LipD 0.0074 0.0306 0.2352
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0075 0.0275
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0006 0.004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0212
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0006 0.0006
Brugia malayi hypothetical protein 0.0011 0.0011 0.0033
Toxoplasma gondii hypothetical protein 0.0013 0.0018 0.0186
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0074 0.0307 0.2337
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0133 0.0133
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0306 0.2352
Schistosoma mansoni hypothetical protein 0.0033 0.0114 0.0112
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0097 0.036
Loa Loa (eye worm) hypothetical protein 0.0127 0.0557 0.2108
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0012 0.0015 0.0116
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0313 0.0311
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0285 0.0285
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0039 0.0424
Schistosoma mansoni DNA helicase recq5 0.001 0.0008 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.015 0.103
Mycobacterium tuberculosis Conserved protein 0.0074 0.0306 0.1241
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.029
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0089 0.0609
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0104 0.0671
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0058 0.0056
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0022 0.0152
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.001 0.0006 0.0003
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.001 0.0005 0.0003
Echinococcus granulosus expressed conserved protein 0.0194 0.087 0.087
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0006 0.0006
Toxoplasma gondii exonuclease III APE 0.0039 0.014 0.1721
Schistosoma mansoni intermediate filament proteins 0.0055 0.0218 0.0215
Onchocerca volvulus 0.0021 0.0058 0.0449
Schistosoma mansoni alpha-glucosidase 0.0287 0.1311 0.1309
Onchocerca volvulus 0.0057 0.0226 0.1802
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0104 0.045 0.1702
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0169 0.1162
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0307 0.2337
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.0666 0.4583
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0018 0.0088
Loa Loa (eye worm) hypothetical protein 0.0074 0.0306 0.1154
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0382
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.024 0.1087 0.4124
Mycobacterium ulcerans hypothetical protein 0.0167 0.0746 0.5948
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0011 0.0009 0.0079
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0011 0.0009 0.0061
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.045 0.1702
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.015 0.0147
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.014 0.0963
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0306 0.1241
Trypanosoma brucei phosphoglycerate kinase 0.0179 0.0801 0.5495
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0169 0.113
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0006 0.0011
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0318 0.1453 1
Leishmania major phosphoglycerate kinase C, glycosomal 0.0179 0.0801 0.5511
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0215 0.1478
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.015 0.0997
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0471 0.2177 1
Brugia malayi Nuclear hormone receptor E75 0.001 0.0006 0.0011
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.014 0.014
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0006 0.0003
Mycobacterium ulcerans phosphoglycerate kinase 0.0179 0.0801 0.6398
Echinococcus multilocularis jumonji domain containing 1A 0.001 0.0005 0.0005
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0074 0.0307 0.2337
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0179 0.0801 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0009 0.0009
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0018 0.0123
Echinococcus granulosus lamin dm0 0.0055 0.0218 0.0218
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0497 0.5232
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0058 0.0449
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0212
Brugia malayi Patched family protein 0.0013 0.0018 0.0057
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.0497 0.2134
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.015 0.0997
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Brugia malayi Patched family protein 0.0013 0.0018 0.0057
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0006 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.015 0.0997
Echinococcus granulosus jumonji domain containing 1A 0.001 0.0005 0.0005
Schistosoma mansoni patched 1 0.0089 0.0375 0.0373
Brugia malayi Patched related family protein 4 0.0013 0.0018 0.0057
Loa Loa (eye worm) hypothetical protein 0.0067 0.0276 0.1039
Schistosoma mansoni DNA polymerase eta 0.0067 0.0276 0.0273
Trichomonas vaginalis maltase-glucoamylase, putative 0.0074 0.0307 0.2337
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0058 0.0056
Brugia malayi hypothetical protein 0.0011 0.0011 0.0033
Brugia malayi beta-lactamase family protein 0.0074 0.0306 0.1154
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0306 0.1154
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0198 0.1361
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.0275
Schistosoma mansoni phd/f-box containing protein 0.001 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Entamoeba histolytica hypothetical protein 0.0075 0.0313 0.321
Echinococcus multilocularis dnaJ subfamily B 0.043 0.1983 0.1983
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0018 0.016
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.001 0.0005 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0058 0.0212
Brugia malayi conserved hypotetical protein 0.001 0.0006 0.0011
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0011 0.0033
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0058 0.0058
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.0568 0.2631 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0104 0.0671
Plasmodium falciparum phosphoglycerate kinase 0.0179 0.0801 1
Echinococcus multilocularis lamin 0.0055 0.0218 0.0218
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0063 0.0726
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0089 0.0544
Brugia malayi Patched family protein 0.0013 0.0018 0.0057
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0009 0.0061
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.012 0.108
Toxoplasma gondii patched family protein 0.0013 0.0018 0.0186
Trypanosoma cruzi DNA polymerase eta, putative 0.0067 0.0276 0.1897
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0005 0.001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0058 0.0058
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.014 0.0963
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0104 0.1241
Brugia malayi nuclear receptor NHR-67 0.001 0.0006 0.0011
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0144 0.0991
Loa Loa (eye worm) patched family protein 0.0013 0.0018 0.0057
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0114 0.0424
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0058 0.0212
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0074 0.0307 0.1159
Plasmodium vivax SET domain protein, putative 0.0035 0.0123 0.1481
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0075 0.0466
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0307 0.2337
Brugia malayi tailless protein 0.001 0.0006 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.015 0.0997
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0075 0.0275
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0179 0.0801 0.6384
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.019 0.0852 0.3232
Schistosoma mansoni hypothetical protein 0.0075 0.0313 0.0311
Loa Loa (eye worm) hypothetical protein 0.0074 0.0306 0.1154
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0212
Brugia malayi PHD-finger family protein 0.0031 0.0103 0.0382
Brugia malayi nuclear hormone receptor 0.0021 0.0058 0.0212
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0008 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.015 0.0997
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0313 0.0313
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0124 0.0462
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0285 0.0283
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0033
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0123 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0058 0.0212
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0318 0.1453 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0084 0.0308
Loa Loa (eye worm) hypothetical protein 0.0057 0.0226 0.085
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0006 0.0006
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0497 0.3889
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0198 0.144
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0058
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0206 0.0929 0.3525
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0003 0.0003
Giardia lamblia Phosphoglycerate kinase 0.0179 0.0801 1
Trypanosoma brucei unspecified product 0.0028 0.009 0.0588
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0018 0.0088
Schistosoma mansoni hypothetical protein 0.0033 0.0114 0.0112
Loa Loa (eye worm) hypothetical protein 0.0074 0.0306 0.1154
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.012 0.0826
Brugia malayi Nuclear hormone receptor E75 0.001 0.0006 0.0011
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1655 0.7745 0.7745
Brugia malayi nuclear receptor NHR-88 0.0021 0.0058 0.0212
Onchocerca volvulus 0.0025 0.0075 0.0584
Brugia malayi hypothetical protein 0.0013 0.0018 0.0057
Echinococcus multilocularis Niemann Pick C1 protein 0.0295 0.1346 0.1346
Brugia malayi Patched family protein 0.0013 0.0018 0.0057
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0006 0.0006
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.015 0.0997
Loa Loa (eye worm) hypothetical protein 0.0055 0.0218 0.0818
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0011 0.0009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0058 0.0212
Echinococcus multilocularis geminin 0.0524 0.2424 0.2424
Schistosoma mansoni nuclear receptor 0.001 0.0006 0.0003
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0295 0.1111
Schistosoma mansoni DNA helicase recq1 0.001 0.0008 0.0005
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0078 0.0454
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0306 0.1241
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0011 0.0011
Schistosoma mansoni survival motor neuron protein 0.0051 0.0197 0.0195
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0066 0.0268 0.1843
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0306 0.1241
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0058 0.0056
Echinococcus multilocularis JmjC domain containing protein 4 0.001 0.0005 0.0005
Echinococcus granulosus peregrin 0.0031 0.0103 0.0103
Onchocerca volvulus 0.0013 0.0018 0.012
Echinococcus granulosus sterol regulatory element binding protein 0.0089 0.0375 0.0375
Toxoplasma gondii histone lysine demethylase JMJD6a 0.001 0.0005 0.0033
Leishmania major phosphoglycerate kinase B, cytosolic 0.0179 0.0801 0.5511
Onchocerca volvulus 0.0013 0.0018 0.012
Onchocerca volvulus 0.0074 0.0306 0.2446
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0266 0.0264
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0306 0.2326
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.015 0.0997
Schistosoma mansoni nuclear hormone receptor 0.001 0.0006 0.0003
Treponema pallidum phosphoglycerate kinase 0.0179 0.0801 1
Brugia malayi hypothetical protein 0.0249 0.1129 0.4285
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0497 0.0494
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0306 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0058 0.0212
Leishmania major DNA polymerase eta, putative 0.0039 0.0144 0.0991
Trypanosoma brucei glycosyl hydrolase-like protein 0.0028 0.0089 0.0575
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0306 0.2326
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0066 0.0268 0.1843
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.015 0.015
Mycobacterium ulcerans glutaminase 0.0273 0.1242 1
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0497 0.3889
Schistosoma mansoni rotamase 0.0035 0.0124 0.0121
Schistosoma mansoni hypothetical protein 0.0085 0.036 0.0358
Loa Loa (eye worm) hypothetical protein 0.0249 0.1129 0.4285
Leishmania major alpha glucosidase II subunit, putative 0.0074 0.0307 0.2114
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0198 0.0198
Trypanosoma brucei DNA polymerase eta, putative 0.0067 0.0276 0.1868
Echinococcus granulosus lysine specific demethylase 6a 0.001 0.0005 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0306 0.2326
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0075 0.0516
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0198 0.0195
Brugia malayi jmjC domain containing protein 0.01 0.0431 0.1631
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0018 0.0088
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0074 0.0306 0.1154
Entamoeba histolytica phosphoglycerate kinase, putative 0.0179 0.0801 0.8588
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0058 0.0058
Brugia malayi phosphofructokinase 0.0114 0.0497 0.1879
Loa Loa (eye worm) patched family protein 0.0013 0.0018 0.0057
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.0666 0.4563
Echinococcus granulosus tumor protein p63 0.0388 0.1785 0.1785
Schistosoma mansoni hypothetical protein 0.0524 0.2424 0.2422
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0003 0.0003
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0104 0.1241
Schistosoma mansoni cpg binding protein 0.0032 0.0109 0.0106
Toxoplasma gondii patched family protein 0.0013 0.0018 0.0186
Toxoplasma gondii hypothetical protein 0.0051 0.02 0.2469
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0212
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.014 0.0931
Loa Loa (eye worm) beta-lactamase 0.0074 0.0306 0.1154
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0285 0.0285
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0285 0.2902
Schistosoma mansoni hypothetical protein 0.043 0.1983 0.1981
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0006 0.004
Echinococcus multilocularis GPCR, family 2 0.0033 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Toxoplasma gondii patched family protein 0.0013 0.0018 0.0186
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0179 0.0801 0.3559
Brugia malayi Patched related family protein 12 0.0013 0.0018 0.0057
Leishmania major glycosyl hydrolase-like protein 0.0028 0.0089 0.0609
Onchocerca volvulus Alhambra homolog 0.0031 0.0103 0.0809
Brugia malayi Niemann-Pick C1 protein precursor 0.0206 0.0929 0.3525
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.014 0.1694
Schistosoma mansoni hypothetical protein 0.0568 0.2631 0.2629
Echinococcus granulosus lamin 0.0055 0.0218 0.0218
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0197 0.0741
Brugia malayi MAP kinase sur-1 0.0051 0.0198 0.0743
Brugia malayi polk-prov protein 0.0013 0.0018 0.0058
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.015 0.0559
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0009 0.0009
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.015 0.051
Schistosoma mansoni ap endonuclease 0.0039 0.014 0.0137
Echinococcus multilocularis protein dispatched 1 0.0101 0.0434 0.0434
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0058 0.0056
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.0497 0.3417
Brugia malayi jmjC domain containing protein 0.001 0.0005 0.001
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0006 0.0024
Echinococcus granulosus dnaJ subfamily B 0.043 0.1983 0.1983
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0103 0.1228
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0075 0.0516
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0033
Schistosoma mansoni lamin 0.0055 0.0218 0.0215
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0206 0.0929 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Brugia malayi Glycosyl hydrolases family 31 protein 0.0334 0.153 0.581
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.0497 0.5808
Echinococcus granulosus intermediate filament protein 0.0055 0.0218 0.0218
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0089 0.0544
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.014 0.1694
Brugia malayi jmjC domain containing protein 0.001 0.0005 0.001
Echinococcus multilocularis dna polymerase kappa 0.0041 0.015 0.015
Schistosoma mansoni hypothetical protein 0.0051 0.0197 0.0195
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0198 0.0198
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0012 0.0013 0.0013
Brugia malayi Pre-SET motif family protein 0.0035 0.0123 0.0458
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0123 0.0121
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0058 0.0058
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0006 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0123 0.0121
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0058 0.0056
Brugia malayi beta-lactamase 0.0074 0.0306 0.1154
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0285 0.1934
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0058 0.0212
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0058 0.0058
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0198 0.1361
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0003 0.0003
Brugia malayi nuclear hormone receptor 0.001 0.0006 0.0011
Brugia malayi nuclear receptor RXR 0.0011 0.0011 0.0033
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0075 0.0466
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0009 0.0025
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0058 0.0056
Brugia malayi Patched family protein 0.0013 0.0018 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0058 0.0212
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0058 0.0212
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0058 0.0056
Echinococcus granulosus JmjC domain containing protein 4 0.001 0.0005 0.0005
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0046 0.0507
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0058 0.0212
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.0163
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0179 0.0801 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0123 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0124 0.0835
Loa Loa (eye worm) patched family protein 0.0013 0.0018 0.0057
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.014 0.1655
Loa Loa (eye worm) patched family protein 0.0013 0.0018 0.0057
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0075 0.0466
Onchocerca volvulus 0.0074 0.0306 0.2446
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Loa Loa (eye worm) hypothetical protein 0.0026 0.0079 0.029
Schistosoma mansoni cpg binding protein 0.0032 0.0109 0.0106
Loa Loa (eye worm) glutaminase 0.0273 0.1242 0.4715
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0058 0.0212
Brugia malayi Pre-SET motif family protein 0.024 0.1087 0.4124
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.015 0.015
Brugia malayi MH2 domain containing protein 0.0119 0.0518 0.1962
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.001
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.0497 0.5633
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0518 0.1962
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0089 0.0375 0.1417
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0306 0.0303
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0198 0.2397
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0011 0.0009
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0104 0.1241
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0058 0.0056
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0075 0.016
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0103 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0058 0.0212
Schistosoma mansoni nuclear receptor 0.001 0.0006 0.0003
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0285 0.1076
Trichomonas vaginalis rotamase, putative 0.0035 0.0124 0.0835
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0169 0.1162
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.014 0.1668
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0006 0.0006
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0104 0.0903
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.015 0.0147
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0142 0.0139
Schistosoma mansoni hypothetical protein 0.0085 0.036 0.0358
Schistosoma mansoni hypothetical protein 0.0524 0.2424 0.2422
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.0163
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0012 0.0013 0.0013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0058 0.0212
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.015 0.0997
Brugia malayi Myosin head containing protein 0.0013 0.0018 0.0057
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0022 0.0152
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0142 0.0142
Schistosoma mansoni jumonji domain containing protein 0.001 0.0005 0.0003
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.1129 0.1129
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0006 0.0003
Brugia malayi Patched family protein 0.0013 0.0018 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0123 0.0121
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.015 0.103
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0307 0.2337
Echinococcus multilocularis lysine specific demethylase 6a 0.001 0.0005 0.0005
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0074 0.0307 0.3144
Echinococcus granulosus transcription factor Dp 1 0.004 0.0148 0.0148
Schistosoma mansoni lamin 0.0055 0.0218 0.0215
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0307 0.2114
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0097 0.036
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0046 0.0507
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0313 0.0313
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0008 0.0019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0058 0.0212
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0003 0.0003
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0055 0.02
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0306 0.2352
Brugia malayi protein C24B5.3 0.0013 0.0018 0.0057
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.0497 0.5232
Echinococcus multilocularis lysosomal alpha glucosidase 0.0334 0.153 0.153
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0058 0.0058
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0257 0.0966
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Entamoeba histolytica hypothetical protein 0.0075 0.0313 0.321
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0058 0.0212
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0104 0.1241
Echinococcus granulosus phosphoglycerate kinase 1 0.0179 0.0801 0.0801
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0104 0.127
Leishmania major mitochondrial DNA polymerase beta 0.0318 0.1453 1
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0005 0.001
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0006 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Brugia malayi hypothetical protein 0.001 0.0006 0.0011
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0066 0.0268 0.1843
Loa Loa (eye worm) hypothetical protein 0.0054 0.0213 0.08
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0075 0.0466
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0074 0.0307 0.3144
Schistosoma mansoni nuclear hormone receptor 0.001 0.0006 0.0003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0234 0.2897
Brugia malayi Phosphoglycerate kinase 0.0179 0.0801 0.3037
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Brugia malayi ecdysone receptor 0.001 0.0006 0.0011
Plasmodium falciparum phd finger protein, putative 0.0031 0.0103 0.1228
Brugia malayi hypothetical protein 0.0075 0.0313 0.1182
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.0163
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0006 0.0011
Onchocerca volvulus 0.0055 0.0218 0.1734
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0018 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0018 0.0088
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0179 0.0801 0.5511
Brugia malayi jmjC domain containing protein 0.0039 0.0142 0.0528
Leishmania major hypothetical protein, conserved 0.0074 0.0306 0.2104
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0218 0.0818
Brugia malayi Patched protein homolog 1 0.0013 0.0018 0.0057
Toxoplasma gondii patched family protein 0.0013 0.0018 0.0186
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0101 0.0373
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.012 0.0826
Trichomonas vaginalis esterase, putative 0.0074 0.0306 0.2326
Brugia malayi intermediate filament protein 0.0055 0.0218 0.0818
Brugia malayi jmjC domain containing protein 0.001 0.0005 0.001
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.019 0.0852 0.6854
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0209 0.0944 0.0942
Schistosoma mansoni hypothetical protein 0.0031 0.0103 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.015 0.0997
Entamoeba histolytica hypothetical protein 0.0075 0.0313 0.321
Brugia malayi steroid hormone receptor 0.0021 0.0058 0.0212
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.015 0.103
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0089 0.0732
Echinococcus multilocularis expressed conserved protein 0.0194 0.087 0.087
Trypanosoma brucei phosphoglycerate kinase, putative 0.0066 0.0268 0.1814
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0058 0.0058
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.0746 0.3301
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.009 0.0588
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0169 0.1162
Echinococcus multilocularis dna polymerase eta 0.0067 0.0276 0.0276
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0198 0.144
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0019
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0198 0.2445
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0123 0.0121
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.012 0.1471
Brugia malayi 6-phosphofructokinase 0.0114 0.0497 0.1879
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0058 0.0058
Trichomonas vaginalis set domain proteins, putative 0.0273 0.1242 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0285 0.1076
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.045 0.1702
Echinococcus multilocularis protein patched 0.0089 0.0375 0.0375
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0006 0.0006
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0089 0.0544
Loa Loa (eye worm) hypothetical protein 0.0053 0.0206 0.0774
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Onchocerca volvulus 0.001 0.0006 0.0024
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.0431 0.0431
Trichomonas vaginalis rotamase, putative 0.0034 0.012 0.0803
Onchocerca volvulus 0.0193 0.0867 0.6977
Loa Loa (eye worm) glutaminase 2 0.0273 0.1242 0.4715
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0179 0.0801 0.6384
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Onchocerca volvulus 0.0013 0.0018 0.012
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0058 0.0058
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0104 0.0773
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.014 0.13
Brugia malayi Bromodomain containing protein 0.0031 0.0103 0.0382
Brugia malayi Phosphoglycerate kinase 0.0066 0.0268 0.1009
Loa Loa (eye worm) hypothetical protein 0.0028 0.0089 0.0327
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.012 0.0793
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0008 0.0008
Mycobacterium tuberculosis Conserved protein 0.0074 0.0306 0.1241
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.015 0.1046
Trypanosoma brucei phosphoglycerate kinase 0.0066 0.0268 0.1814
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0074 0.0307 0.3816
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0104 0.0671
Brugia malayi CXXC zinc finger family protein 0.003 0.0101 0.0373
Echinococcus multilocularis neutral alpha glucosidase AB 0.0074 0.0307 0.0307
Onchocerca volvulus 0.0055 0.0218 0.1734
Echinococcus multilocularis cpg binding protein 0.0032 0.0109 0.0109
Trypanosoma brucei protein kinase, putative 0.0051 0.0198 0.133
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0142 0.0528
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0008 0.0064
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0058 0.0056
Leishmania major hypothetical protein, conserved 0.001 0.0005 0.0036
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0075 0.0466
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0008 0.0019
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.016 0.016
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0058 0.0058
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0066 0.0268 0.1843
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.015 0.1076
Onchocerca volvulus 0.0074 0.0306 0.2446
Echinococcus granulosus cpg binding protein 0.0032 0.0109 0.0109
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0058 0.0058
Leishmania major DNA polymerase kappa, putative 0.0041 0.015 0.103
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0212
Loa Loa (eye worm) hypothetical protein 0.0074 0.0306 0.1154
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0058 0.0449
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.015 0.051
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.045 0.1702
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0114 0.0114
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0218 0.0818
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0306 0.1241
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0089 0.0609
Brugia malayi jmjC domain containing protein 0.001 0.0005 0.001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0306 0.1154
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0033
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0104 0.0671
Trichomonas vaginalis glutaminase, putative 0.0273 0.1242 0.9998
Brugia malayi nuclear receptor RXR 0.001 0.0006 0.0011
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0006 0.0003
Schistosoma mansoni alpha-glucosidase 0.0287 0.1311 0.1309
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Brugia malayi Patched related family protein 10 0.0013 0.0018 0.0057
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0306 0.318
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0053 0.005
Mycobacterium leprae Probable lipase LipE 0.0074 0.0306 0.318
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0103 0.01
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0058 0.0056
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0198 0.0198
Schistosoma mansoni hypothetical protein 0.0033 0.0114 0.0112
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0018 0.0192
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0005 0.001
Echinococcus granulosus Protein patched homolog 1 0.0089 0.0375 0.0375
Giardia lamblia DNA damage repair protein 0.0013 0.0018 0.0129
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0104 0.0671
Echinococcus granulosus dna polymerase kappa 0.0041 0.015 0.015
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0011 0.0011
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0497 0.3889
Brugia malayi beta-lactamase family protein 0.0074 0.0306 0.1154
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0003 0.0003
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.0497 0.0497
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0018 0.0088
Brugia malayi Patched family protein 0.0013 0.0018 0.0057
Giardia lamblia PHD finger protein 15 0.0031 0.0103 0.1201
Echinococcus granulosus expressed protein 0.0035 0.0124 0.0124
Echinococcus multilocularis expressed protein 0.0035 0.0124 0.0124
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.015 0.0997
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0033
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.014 0.0523
Brugia malayi Patched family protein 0.0013 0.0018 0.0057
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0018 0.0088
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0123 0.1509
Schistosoma mansoni protein phosphatase 2C 0.001 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0046 0.0022
Brugia malayi Glycosyl hydrolases family 31 protein 0.0074 0.0307 0.1159
Brugia malayi ImpB/MucB/SamB family protein 0.0067 0.0276 0.1039
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0226 0.0223
Schistosoma mansoni hypothetical protein 0.0085 0.036 0.0358
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0043
Brugia malayi protein C24B5.3 0.0013 0.0018 0.0057
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0078 0.0454
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0497 0.3393
Echinococcus multilocularis sterol regulatory element binding protein 0.0089 0.0375 0.0375
Echinococcus multilocularis musashi 0.0055 0.0218 0.0218
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0075 0.0583
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0008 0.0031
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0306 0.0306
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0047 0.0044
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0058 0.0056
Brugia malayi Patched family protein 0.0013 0.0018 0.0057
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0009 0.0023
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0114 0.0114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0058 0.0212
Loa Loa (eye worm) hypothetical protein 0.0089 0.0375 0.1417
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.012 0.0826
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.0431 0.0431
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0306 0.1241
Echinococcus multilocularis Niemann Pick C1 protein 0.0206 0.0929 0.0929
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0058 0.0449
Schistosoma mansoni hypothetical protein 0.0071 0.0295 0.0292
Echinococcus granulosus neutral alpha glucosidase AB 0.0074 0.0307 0.0307
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0075 0.0516
Schistosoma mansoni hypothetical protein 0.0085 0.036 0.0358
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0198 0.144
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0104 0.127
Echinococcus multilocularis lamin dm0 0.0055 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0009 0.0061
Brugia malayi nuclear receptor NHR-88 0.001 0.0006 0.0011
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.1129 0.1129
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.0666 0.4583
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.015 0.103
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0198 0.133
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.0497 0.0494
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Trypanosoma brucei unspecified product 0.0041 0.015 0.0997
Mycobacterium tuberculosis Conserved protein 0.0074 0.0306 0.1241
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0084 0.0084
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.014 0.0517
Loa Loa (eye worm) hypothetical protein 0.0018 0.0046 0.0163
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0075 0.0466
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.014 0.0963
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0334 0.153 0.581
Trichomonas vaginalis sucrase-isomaltase, putative 0.0074 0.0307 0.2337
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0028 0.0089 0.0693
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0104 0.0671
Trypanosoma brucei glucosidase, putative 0.0074 0.0307 0.2086
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0066 0.0268 0.1843
Onchocerca volvulus 0.0013 0.0018 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0306 0.2104
Echinococcus granulosus dna polymerase eta 0.0067 0.0276 0.0276
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.015 0.1406
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0006 0.0006
Brugia malayi 6-phosphofructokinase 0.0114 0.0497 0.1879
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0066 0.0268 0.1843
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.0089 0.0327
Entamoeba histolytica hypothetical protein 0.0075 0.0313 0.321
Schistosoma mansoni phosphoglycerate kinase 0.0179 0.0801 0.0799
Loa Loa (eye worm) hypothetical protein 0.0033 0.0114 0.0424
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0046 0.0226
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0006 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0006 0.0006
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0089 0.0544
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.009 0.0588
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0084 0.0084
Leishmania major DNA polymerase eta, putative 0.0067 0.0276 0.1897
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0011 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0212
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0306 0.2104
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0058 0.0212
Schistosoma mansoni hypothetical protein 0.0033 0.0114 0.0112
Brugia malayi AF-10 protein 0.001 0.0006 0.0012
Schistosoma mansoni cpg binding protein 0.003 0.0101 0.0098
Echinococcus granulosus bloom syndrome protein 0.0025 0.0078 0.0078
Echinococcus multilocularis lysosomal alpha glucosidase 0.0334 0.153 0.153
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0142 0.0139
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0039 0.0144 0.1771
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0058 0.0212
Leishmania major DNA damage repair protein, putative 0.0013 0.0018 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.015 0.0997
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0306 0.2326
Mycobacterium ulcerans beta-lactamase 0.0074 0.0306 0.2352
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0124 0.0462
Onchocerca volvulus Protein patched homolog 0.0013 0.0018 0.012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0123 0.0458
Onchocerca volvulus 0.0013 0.0018 0.012
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0008 0.0064
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0018 0.0088
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0074 0.0306 0.1154
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.0497 0.1879
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0075 0.0275
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0306 0.2076
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0103 0.1257
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0058 0.0058
Brugia malayi ecdysteroid receptor 0.0021 0.0058 0.0212
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0198 0.144
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0307 0.2337
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Brugia malayi Patched family protein 0.0013 0.0018 0.0057
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.0568 0.2631 0.2631
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0018 0.0192
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.014 0.0523
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0058 0.0212
Giardia lamblia DINP protein human, muc B family 0.0041 0.015 0.179
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0285 0.1963
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0058 0.0058
Loa Loa (eye worm) phosphofructokinase 0.0114 0.0497 0.1879
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0212
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0114 0.0424
Schistosoma mansoni phosphatidylserine receptor 0.001 0.0005 0.0003
Mycobacterium ulcerans hypothetical protein 0.0074 0.0306 0.2352
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0306 0.1241
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Plasmodium falciparum lipid/sterol:H+ symporter 0.0013 0.0018 0.0154
Plasmodium vivax patched family protein, putative 0.0013 0.0018 0.0154
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.0275
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0198 0.0743
Trypanosoma brucei phosphoglycerate kinase 0.0179 0.0801 0.5495
Brugia malayi Patched family protein 0.0013 0.0018 0.0057
Toxoplasma gondii ABC1 family protein 0.0074 0.0306 0.3798
Schistosoma mansoni phosphoglycerate kinase 0.0179 0.0801 0.0799
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0058 0.0058
Onchocerca volvulus 0.0013 0.0018 0.012
Onchocerca volvulus Protein patched homolog 0.0013 0.0018 0.012
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.0275
Brugia malayi CHE-14 protein 0.0089 0.0375 0.1417
Loa Loa (eye worm) patched family protein 0.0013 0.0018 0.0057
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0103 0.0103
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0058 0.0212
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.015 0.1046
Echinococcus granulosus phd:f box containing protein 0.001 0.0005 0.0005
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0078 0.0285
Schistosoma mansoni jumonji domain containing protein 0.008 0.0334 0.0332
Brugia malayi hypothetical protein 0.0013 0.0018 0.0057
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0015 0.0116
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.0497 0.3889
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.0497 0.0497
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0018 0.0123
Brugia malayi hypothetical protein 0.0013 0.0018 0.0057
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.014 0.0966
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.001 0.0005 0.0033
Onchocerca volvulus 0.0013 0.0018 0.012
Echinococcus multilocularis phosphoglycerate kinase 1 0.0179 0.0801 0.0801
Brugia malayi N-terminal motif family protein 0.019 0.0852 0.3232
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0306 0.1241
Brugia malayi Patched family protein 0.0013 0.0018 0.0057
Echinococcus multilocularis phd:f box containing protein 0.001 0.0005 0.0005
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0198 0.1361
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0306 0.2326
Schistosoma mansoni hypothetical protein 0.0568 0.2631 0.2629
Brugia malayi glutaminase DH11.1 0.0273 0.1242 0.4715
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0179 0.0801 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0008 0.0019
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0218 0.0818
Schistosoma mansoni glutaminase 0.0273 0.1242 0.124
Onchocerca volvulus 0.0051 0.0197 0.1571
Echinococcus granulosus Niemann Pick C1 protein 0.0206 0.0929 0.0929
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0285 0.1963
Echinococcus granulosus jumonji domain containing protein 0.0043 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0071 0.0295 0.1111
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.014 0.0997
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.015 0.0997
Brugia malayi hypothetical protein 0.001 0.0006 0.0011
Brugia malayi Patched family protein 0.0013 0.0018 0.0057
Echinococcus granulosus GPCR family 2 0.0033 0.0114 0.0114
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0518 0.1962
Echinococcus multilocularis peregrin 0.0031 0.0103 0.0103
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.0497 0.3417
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0058 0.0212
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0089 0.0544
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0058 0.0058
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.0089 0.0544
Loa Loa (eye worm) RecQ helicase 0.0025 0.0078 0.0285
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0058 0.0212
Trypanosoma brucei unspecified product 0.0028 0.009 0.0588
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0006 0.0004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0114 0.0114
Onchocerca volvulus 0.003 0.0101 0.0792
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.009 0.0588
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.015 0.0559
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0089 0.0544
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0123 0.0123
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.0497 0.3911
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0307 0.2114
Loa Loa (eye worm) hypothetical protein 0.0013 0.0018 0.0057
Plasmodium vivax phosphoglycerate kinase, putative 0.0179 0.0801 1
Echinococcus granulosus geminin 0.0524 0.2424 0.2424
Schistosoma mansoni zinc finger protein 0.001 0.0006 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.015 0.0997
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0104 0.1214
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0306 0.3778
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0075 0.0466
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0033
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0075 0.0583
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0038 0.0444
Onchocerca volvulus 0.001 0.0006 0.0024

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 18.56 uM Cytotoxicity against mouse J774A1 cells assessed as cell viability after 72 hrs by MTT assay ChEMBL. 21385661
IC50 (functional) = 7.36 uM Antiamastigote activity against Leishmania donovani MHOM/IN/80/Dd8 amastigotes infected in mouse macrophage after 72 hrs by luciferase reporter gene assay ChEMBL. 21385661
Inhibition (functional) = 97.5 % Antipromastigote activity against Leishmania donovani MHOM/IN/80/Dd8 promastigotes assessed as luciferase activity of viable cells at 20 uM after 72 hrs by luminometry ChEMBL. 21385661

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Leishmania donovani ChEMBL23 21385661

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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