Detailed information for compound 157716

Basic information

Technical information
  • TDR Targets ID: 157716
  • Name: 1,6-dibenzyl-N-(2,2-dimethylpropyl)-2,3-dihyd roindene-1-carboxamide
  • MW: 411.578 | Formula: C29H33NO
  • H donors: 1 H acceptors: 1 LogP: 6.99 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1(CCc2c1cc(cc2)Cc1ccccc1)Cc1ccccc1)NCC(C)(C)C
  • InChi: 1S/C29H33NO/c1-28(2,3)21-30-27(31)29(20-23-12-8-5-9-13-23)17-16-25-15-14-24(19-26(25)29)18-22-10-6-4-7-11-22/h4-15,19H,16-18,20-21H2,1-3H3,(H,30,31)
  • InChiKey: JYGMGOJJQFYGHI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,6-dibenzyl-N-(2,2-dimethylpropyl)indane-1-carboxamide
  • 1,6-dibenzyl-N-(2,2-dimethylpropyl)-1-indanecarboxamide
  • N-(2,2-dimethylpropyl)-1,6-bis(phenylmethyl)-2,3-dihydroindene-1-carboxamide
  • 1,6-dibenzyl-N-neopentyl-indane-1-carboxamide
  • N-(2,2-dimethylpropyl)-1,6-bis(phenylmethyl)indane-1-carboxamide
  • N-(2,2-dimethylpropyl)-1,6-bis(phenylmethyl)-1-indanecarboxamide
  • 1,6-bis(benzyl)-N-neopentyl-indane-1-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tachykinin receptor 3 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tachykinin peptides receptor 99D Get druggable targets OG5_131969 All targets in OG5_131969
Echinococcus multilocularis tachykinin peptides receptor 99D Get druggable targets OG5_131969 All targets in OG5_131969
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.6752 1 1
Trypanosoma brucei heat shock protein 90, putative 0.0051 0.0054 0.0054
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0021 0.0009 0.0009
Echinococcus granulosus serine protein kinase ATM 0.1277 0.1873 0.1873
Schistosoma mansoni 60S ribosomal protein L21 0.0024 0.0014 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.2264 0.3339 0.3339
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1277 0.1873 0.1873
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0436 0.0624 0.0624
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0062 0.007 1
Toxoplasma gondii heat shock protein 90, putative 0.0051 0.0054 0.0062
Echinococcus granulosus Glutaredoxin protein 5 0.0062 0.007 0.0069
Echinococcus multilocularis rac serine:threonine kinase 0.0069 0.008 0.008
Echinococcus multilocularis protein kinase c epsilon type 0.0032 0.0026 0.0026
Echinococcus multilocularis kelch ECH associated protein 1 0.0075 0.0089 0.0088
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.002 0.0008 0.0007
Giardia lamblia Kinase, PLK 0.0075 0.009 0.0089
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0436 0.0624 0.0624
Schistosoma mansoni similar to Protein C20orf152 homolog 0.002 0.0008 0.0007
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0436 0.0624 0.0624
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0153 0.0204 0.0204
Brugia malayi heat shock protein 90 0.0051 0.0054 0.0054
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0053 0.0056 0.0056
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.003 0.0023 0.0022
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0032 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.1423 0.209 0.209
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0008 0.0007
Schistosoma mansoni immunophilin 0.0046 0.0046 0.0045
Loa Loa (eye worm) transcription factor SMAD2 0.0094 0.0118 0.0117
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.003 0.0023 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.2264 0.3339 0.3339
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.003 0.0023 0.0022
Schistosoma mansoni hypothetical protein 0.0436 0.0624 0.0624
Trichomonas vaginalis AGC family protein kinase 0.01 0.0127 0.0126
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0436 0.0624 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.3994 0.5907 0.5907
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0029 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0029 0.0021 0.0021
Entamoeba histolytica protein kinase, putative 0.01 0.0127 0.0126
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0436 0.0624 0.0831
Trichomonas vaginalis PIKK family atypical protein kinase 0.4034 0.5966 0.5966
Trypanosoma brucei heat shock protein, putative 0.0051 0.0054 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0841 0.1227 0.1226
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0056 0.0056
Leishmania major heat shock protein 83-1 0.0051 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0436 0.0624 0.0624
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0034 0.0033
Echinococcus multilocularis Kelch repeat type 1 0.0075 0.0089 0.0088
Echinococcus multilocularis voltage gated potassium channel 0.0044 0.0043 0.0043
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.002 0.0008 0.0007
Echinococcus multilocularis serine protein kinase ATM 0.1277 0.1873 0.1873
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0436 0.0624 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0053 0.0056 0.8107
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.6752 1 1
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0055 0.0059 0.0059
Trypanosoma brucei polo-like protein kinase 0.0075 0.009 0.009
Leishmania major hypothetical protein, conserved 0.0436 0.0624 0.0624
Mycobacterium ulcerans hypothetical protein 0.002 0.0008 0.1057
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1277 0.1873 0.1873
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0436 0.0624 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.3646 0.5389 0.5389
Trichomonas vaginalis PIKK family atypical protein kinase 0.5022 0.7432 0.7432
Loa Loa (eye worm) phosphatidylinositol 3 0.0436 0.0624 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.537 0.7949 0.7949
Trypanosoma brucei heat shock protein, putative 0.0051 0.0054 0.0054
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0436 0.0624 0.0624
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0436 0.0624 0.0624
Trypanosoma brucei Heat shock protein 83, putative 0.0051 0.0054 0.0054
Plasmodium falciparum endoplasmin, putative 0.0032 0.0025 0.0273
Trypanosoma cruzi heat shock protein 90, putative 0.003 0.0023 0.0022
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0025 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.5765 0.8535 0.8534
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.002 0.0008 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0436 0.0624 0.0624
Trypanosoma brucei rac serine-threonine kinase, putative 0.01 0.0127 0.0127
Echinococcus multilocularis heat shock protein 0.0051 0.0054 0.0054
Trichomonas vaginalis endoplasmin, putative 0.0032 0.0025 0.0024
Mycobacterium leprae conserved hypothetical protein 0.0436 0.0624 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0436 0.0624 0.0624
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0053 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.002 0.0008 0.0007
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0436 0.0624 0.0624
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0053 0.0056 0.0056
Leishmania major hypothetical protein, unknown function 0.002 0.0008 0.0007
Brugia malayi Endoplasmin precursor 0.0051 0.0054 0.0054
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1277 0.1873 0.1873
Schistosoma mansoni peptidase Clp (S14 family) 0.0062 0.007 0.0069
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0062 0.007 0.0083
Trypanosoma brucei heat shock protein, putative 0.0051 0.0054 0.0054
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0062 0.007 1
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0063 0.0071 0.1025
Trichomonas vaginalis AGC family protein kinase 0.01 0.0127 0.0126
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.1376 0.202 0.202
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0436 0.0624 0.0624
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0075 0.009 0.0089
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0032 0.0026 0.0026
Echinococcus multilocularis expressed conserved protein 0.0021 0.0009 0.0009
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0436 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0841 0.1227 0.1226
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.6752 1 1
Toxoplasma gondii hypothetical protein 0.0021 0.0009 0.0002
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2264 0.3339 0.3339
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0436 0.0624 0.0624
Trypanosoma brucei heat shock protein, putative 0.0051 0.0054 0.0054
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0056 0.0056
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0021 0.0009 0.0027
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0045 0.0045 0.0716
Mycobacterium ulcerans transmembrane transport protein 0.002 0.0008 0.1057
Echinococcus multilocularis protein kinase c iota type 0.0032 0.0026 0.0026
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2804 0.4141 0.4141
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.009 0.0089
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0436 0.0624 1
Trypanosoma cruzi heat shock protein 85, putative 0.0041 0.0038 0.0038
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0032 0.0026 0.0026
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.002 0.0008 0.0007
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0055 0.0059 0.0059
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.002 0.0008 0.0007
Trypanosoma brucei heat shock protein 90, putative 0.0051 0.0054 0.0054
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0032 0.0026 0.0026
Schistosoma mansoni tsg101-related 0.0037 0.0033 0.0033
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.6752 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0436 0.0624 0.0624
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0062 0.007 0.1002
Echinococcus granulosus ubiquitin specific protease 41 0.0029 0.0021 0.0021
Plasmodium falciparum heat shock protein 90 0.0051 0.0054 0.0751
Plasmodium vivax endoplasmin, putative 0.0051 0.0054 0.0751
Schistosoma mansoni immunophilin 0.0053 0.0056 0.0056
Leishmania major heat shock protein 83-1 0.0051 0.0054 0.0054
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0062 0.007 0.0069
Trichomonas vaginalis AGC family protein kinase 0.01 0.0127 0.0126
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.002 0.0008 0.0117
Echinococcus multilocularis heat shock protein 90 0.0051 0.0054 0.0054
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0008 0.0117
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0436 0.0624 0.0831
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0053 0.0056 0.0056
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0153 0.0204 0.0204
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.002 0.0008 0.0007
Brugia malayi Protein kinase domain containing protein 0.0032 0.0026 0.0026
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0029 0.0021 0.0021
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0041 0.0038 0.0601
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0045 0.0045 0.0045
Toxoplasma gondii target of rapamycin (TOR), putative 0.5022 0.7432 1
Trypanosoma cruzi cAMP response protein 1 0.002 0.0008 0.0007
Echinococcus granulosus protein kinase c epsilon type 0.0032 0.0026 0.0026
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.002 0.0008 0.0008
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0436 0.0624 0.0624
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.002 0.0008 0.0007
Entamoeba histolytica hypothetical protein 0.0028 0.002 0.002
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.009 0.0089
Echinococcus granulosus kelch ECH associated protein 1 like 0.0075 0.0089 0.0088
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0052 0.0055 0.0055
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0143 0.019 0.0189
Leishmania major heat shock protein 83-1 0.0051 0.0054 0.0054
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0056 0.0056
Toxoplasma gondii heat shock protein HSP90 0.0051 0.0054 0.0062
Schistosoma mansoni serine/threonine kinase 0.0032 0.0026 0.0026
Treponema pallidum heat shock protein 90 0.0041 0.0038 0.4982
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.009 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.0034 0.0033
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0041 0.0038 0.0038
Trypanosoma brucei DNA polymerase eta, putative 0.0035 0.003 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0026 0.0026
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.6752 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0008 0.0117
Schistosoma mansoni fkbp-rapamycin associated protein 0.1277 0.1873 0.1873
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0023 0.0022
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0841 0.1227 0.1226
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0052 0.0055 0.0055
Brugia malayi protein kinase C II. 0.0032 0.0026 0.0026
Echinococcus granulosus kelch ECH associated protein 1 0.0075 0.0089 0.0088
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0053 0.0056 0.0056
Leishmania major heat shock protein 83-1 0.0051 0.0054 0.0054
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0032 0.0026 0.0026
Brugia malayi Cyclic-nucleotide gated cation channel 0.003 0.0023 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.4034 0.5966 0.5966
Echinococcus multilocularis patatin phospholipase domain containing protein 0.002 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.364 0.5381 0.5381
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0056 0.0056
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0029 0.0021 0.0021
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0018 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.003
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2264 0.3339 0.3339
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0436 0.0624 0.0624
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0008 0.0007
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.002 0.0008 0.0007
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0436 0.0624 0.0624
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0009 0.0009
Brugia malayi p70 ribosomal S6 kinase beta 0.0094 0.0118 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.009 0.0089
Schistosoma mansoni tsg101-related 0.0046 0.0046 0.0045
Echinococcus multilocularis hyperpolarization activated cyclic 0.003 0.0023 0.0022
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0063 0.0071 0.1025
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0436 0.0624 0.0624
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0008 0.0007
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0062 0.007 0.0069
Trypanosoma brucei heat shock protein, putative 0.0051 0.0054 0.0054
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.002 0.0008 0.0007
Trichomonas vaginalis heat shock protein, putative 0.0041 0.0038 0.0038
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.6752 1 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.007 0.0069
Leishmania major phosphatidylinositol 3-kinase, putative 0.0436 0.0624 0.0624
Leishmania major cyclic nucleotide-binding protein-like protein 0.002 0.0008 0.0007
Echinococcus granulosus cyclic nucleotide gated cation channel 0.003 0.0023 0.0022
Loa Loa (eye worm) MH2 domain-containing protein 0.0094 0.0118 0.0117
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.002 0.0008 0.0007
Leishmania major hypothetical protein, conserved 0.002 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.4034 0.5966 0.5966
Brugia malayi Hr1 repeat family protein 0.0032 0.0026 0.0026
Loa Loa (eye worm) AGC/PKG protein kinase 0.0021 0.0009 0.0009
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.003 0.0023 0.0022
Loa Loa (eye worm) phosphatidylinositol 3 0.6752 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0043 0.0043
Entamoeba histolytica heat shock protein 90, putative 0.0051 0.0054 0.0054
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0153 0.0204 0.0204
Trypanosoma cruzi heat shock protein 90, putative 0.0041 0.0038 0.0038
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.003 0.0023 0.0022
Brugia malayi Probable ClpP-like protease 0.0062 0.007 0.0069
Brugia malayi serine/threonine-protein kinase plk-2 0.0075 0.009 0.0089
Leishmania major fk506-binding protein 1-like protein 0.0053 0.0056 0.0056
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0436 0.0624 0.0624
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0436 0.0624 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.537 0.7949 0.7949
Plasmodium falciparum heat shock protein 90, putative 0.0021 0.0009 0.0021
Brugia malayi hypothetical protein 0.0028 0.002 0.002
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0029 0.0021 0.0021
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0436 0.0624 1
Entamoeba histolytica hypothetical protein 0.0436 0.0624 0.0624
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.003 0.0023 0.0022
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.0043 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.6752 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2264 0.3339 0.3339
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.003 0.0023 0.0022
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0062 0.007 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0436 0.0624 0.0624
Echinococcus multilocularis serine:threonine protein kinase N2 0.0032 0.0026 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0008 0.0007
Leishmania major heat shock protein 83-1 0.0051 0.0054 0.0054
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0037 0.0033 0.0033
Mycobacterium ulcerans transcriptional regulatory protein 0.002 0.0008 0.1057
Trypanosoma brucei heat shock protein 84, putative 0.0021 0.0009 0.0009
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0436 0.0624 0.0624
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0046 0.0046 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0026 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.537 0.7949 0.7949
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0436 0.0624 0.0624
Echinococcus granulosus kelch ECH associated protein 1 like 0.0075 0.0089 0.0088
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0436 0.0624 0.0624
Mycobacterium ulcerans heat shock protein 90 0.0041 0.0038 0.5512
Giardia lamblia GTOR 0.6752 1 1
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0018 0.0004 0.0003
Plasmodium falciparum heat shock protein 90, putative 0.0021 0.0009 0.0021
Echinococcus granulosus heat shock protein 90 0.0051 0.0054 0.0054
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.009 0.0089
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0045 0.0045 0.0045
Echinococcus multilocularis serine threonine protein kinase 0.0032 0.0026 0.0026
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0436 0.0624 0.0624
Trypanosoma cruzi Heat shock protein 83, putative 0.0051 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0436 0.0624 0.0624
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.002 0.0008 0.0007
Echinococcus granulosus nervana 2 0.0062 0.007 0.0069
Loa Loa (eye worm) heat shock protein 75 0.0021 0.0009 0.0009
Echinococcus multilocularis ubiquitin specific protease 41 0.0029 0.0021 0.0021
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0436 0.0624 0.0624
Trypanosoma cruzi polo-like protein kinase, putative 0.0075 0.009 0.0089
Schistosoma mansoni voltage-gated potassium channel 0.0167 0.0225 0.0225
Trypanosoma cruzi heat shock protein, putative 0.0021 0.0009 0.0009
Echinococcus granulosus endoplasmin 0.0041 0.0038 0.0038
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0032 0.0026 0.0026
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0053 0.0056 0.0056
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0075 0.009 0.0089
Brugia malayi Egg laying defective protein 4 0.0021 0.0009 0.0009
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0063 0.0071 0.007
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0032 0.0026 0.0026
Echinococcus granulosus nervana 2 0.0062 0.007 0.0069
Trichomonas vaginalis AGC family protein kinase 0.01 0.0127 0.0126
Leishmania major heat shock protein, putative 0.0021 0.0009 0.0009
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0053 0.0056 0.079
Schistosoma mansoni kinase 0.0039 0.0035 0.0035
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0021 0.0009 0.0027
Trichomonas vaginalis AGC family protein kinase 0.01 0.0127 0.0126
Leishmania major heat shock protein 83-1 0.0051 0.0054 0.0054
Schistosoma mansoni tsg101-related 0.0046 0.0046 0.0045
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1277 0.1873 0.1873
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.002 0.0008 0.0007
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.002 0.0008 0.0007
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0436 0.0624 1
Loa Loa (eye worm) AGC/NDR protein kinase 0.0032 0.0026 0.0026
Echinococcus granulosus cGMP dependent protein kinase 1 0.0021 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0028 0.002 0.002
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0053 0.0056 0.0056
Trypanosoma cruzi DNA polymerase eta, putative 0.0025 0.0015 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.2264 0.3339 0.3339
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1277 0.1873 0.1873
Trichomonas vaginalis PIKK family atypical protein kinase 0.364 0.5381 0.5381
Trichomonas vaginalis PIKK family atypical protein kinase 0.3646 0.5389 0.5389
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0436 0.0624 0.0624
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0062 0.007 0.0083
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0143 0.019 0.0189
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0044 0.0043 0.0043
Plasmodium vivax heat shock protein 86, putative 0.0051 0.0054 0.0751
Giardia lamblia Heat shock protein HSP 90-alpha 0.0041 0.0038 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.5022 0.7432 0.7432
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0021 0.0009 0.0009
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0436 0.0624 0.0831
Leishmania major heat shock protein 83-1 0.0051 0.0054 0.0054
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0029 0.0021 0.0021
Echinococcus multilocularis endoplasmin 0.0041 0.0038 0.0038
Giardia lamblia Phosphatidylinositol 4-kinase 0.0436 0.0624 0.0624
Echinococcus granulosus NDR protein kinase 0.0032 0.0026 0.0026
Brugia malayi Protein kinase domain containing protein 0.0032 0.0026 0.0026
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.002 0.0008 0.0007
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0987 0.1443 0.1443
Schistosoma mansoni heat shock protein 0.0051 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0007
Loa Loa (eye worm) endoplasmin 0.0051 0.0054 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0008 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0035 0.0035
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0436 0.0624 0.0624
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0436 0.0624 0.0624
Mycobacterium ulcerans hypothetical protein 0.002 0.0008 0.1057
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0029 0.0021 0.0021
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.003 0.0023 0.0022
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0052 0.0055 0.0055
Trichomonas vaginalis AGC family protein kinase 0.01 0.0127 0.0126
Giardia lamblia Heat shock protein HSP 90-alpha 0.0051 0.0054 0.0054
Leishmania major heat shock protein 83-1 0.0051 0.0054 0.0054
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0436 0.0624 0.0624
Echinococcus granulosus heat shock protein 90 0.0041 0.0038 0.0038
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0436 0.0624 0.0624
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.002 0.0008 0.0007
Entamoeba histolytica protein kinase, putative 0.0094 0.0118 0.0117
Leishmania major heat shock protein 83-1 0.0051 0.0054 0.0054
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.6752 1 1
Mycobacterium ulcerans hypothetical protein 0.002 0.0008 0.1057
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0023 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.5022 0.7432 0.7432
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0023 0.0022
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0436 0.0624 0.0624
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0062 0.007 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0053 0.0056 0.0056
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0032 0.0026 0.0026
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0029 0.0021 0.0021
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0032 0.0026 0.0026
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.002 0.0008 0.0007
Brugia malayi MH2 domain containing protein 0.0094 0.0118 0.0117
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0436 0.0624 0.0624
Leishmania major protein kinase A regulatory subunit, putative 0.002 0.0008 0.0007
Echinococcus granulosus protein kinase C gamma type 0.0032 0.0026 0.0026
Plasmodium vivax heat shock protein, putative 0.0021 0.0009 0.0021
Schistosoma mansoni immunophilin 0.0053 0.0056 0.0056
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.003 0.0023 0.0022
Leishmania major hypothetical protein, conserved 0.002 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0987 0.1443 0.1443
Trypanosoma brucei protein kinase A regulatory subunit 0.002 0.0008 0.0008
Schistosoma mansoni heat shock protein 0.0051 0.0054 0.0054
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.002 0.0008 0.0007
Leishmania major DNA polymerase eta, putative 0.0025 0.0015 0.0014
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0009 0.0009
Schistosoma mansoni serine/threonine-protein kinase 0.0069 0.008 0.008
Trichomonas vaginalis heat shock protein, putative 0.0051 0.0054 0.0054
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2264 0.3339 0.3339
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0028 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.1277 0.1873 0.1873
Echinococcus multilocularis kelch ECH associated protein 1 0.0075 0.0089 0.0088
Schistosoma mansoni atypical protein kinase C 0.0032 0.0026 0.0026
Loa Loa (eye worm) phosphatidylinositol 3 0.0436 0.0624 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.364 0.5381 0.5381
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0436 0.0624 0.0624
Brugia malayi FAT domain containing protein 0.0987 0.1443 0.1443
Trypanosoma cruzi heat shock protein 85, putative 0.0051 0.0054 0.0054
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0436 0.0624 0.0624
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0062 0.007 0.0069
Plasmodium vivax hypothetical protein 0.0436 0.0624 1
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.002 0.0008 0.0007
Trypanosoma cruzi cAMP response protein 1, putative 0.002 0.0008 0.0007
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0032 0.0026 0.0026
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0436 0.0624 0.0624
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0436 0.0624 0.0624
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0094 0.0118 0.0117
Entamoeba histolytica hypothetical protein 0.0436 0.0624 0.0624
Onchocerca volvulus Serine\/threonine kinase homolog 0.0075 0.009 0.1328
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0041 0.0038 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.3646 0.5389 0.5389
Trichomonas vaginalis PIKK family atypical protein kinase 0.5022 0.7432 0.7432
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0021 0.0009 0.0009
Leishmania major heat shock protein 83-1 0.0051 0.0054 0.0054
Brugia malayi hypothetical protein 0.0055 0.0059 0.0059
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0008 0.0007
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0041 0.0038 0.0499
Echinococcus granulosus cGMP dependent protein kinase 0.0021 0.0009 0.0009
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.002 0.0008 0.0007
Leishmania major hypothetical protein, conserved 0.0018 0.0004 0.0003
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0052 0.0055 0.0055
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0023 0.0022
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0052 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0987 0.1443 0.1443
Trichomonas vaginalis PIKK family atypical protein kinase 0.6752 1 1
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.002 0.0008 0.0007
Entamoeba histolytica hypothetical protein 0.0436 0.0624 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.2264 0.3339 0.3339
Leishmania major heat shock protein 83-1 0.0051 0.0054 0.0054
Trypanosoma brucei Flagellar Member 6 0.002 0.0008 0.0008
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.002 0.0008 0.0007
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0436 0.0624 0.0624
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0436 0.0624 0.0624
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0045 0.0045 0.6463
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0029 0.0021 0.0021
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0045 0.0045 0.6463
Trypanosoma cruzi cAMP binding protein, putative 0.002 0.0008 0.0007
Giardia lamblia Grp94/Hsp90 0.0041 0.0038 0.0038
Entamoeba histolytica protein kinase, putative 0.0032 0.0026 0.0026
Entamoeba histolytica heat shock protein 90, putative 0.0051 0.0054 0.0054
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.002 0.0008 0.0117
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0436 0.0624 0.0624
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0043 0.0043
Leishmania major heat shock protein 83-1 0.0051 0.0054 0.0054
Echinococcus granulosus hyperpolarization activated cyclic 0.003 0.0023 0.0022
Trypanosoma brucei heat shock protein, putative 0.0051 0.0054 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.1812 0.2667 0.2667
Echinococcus multilocularis nervana 2 0.0062 0.007 0.0069
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.002 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0046 0.0046 0.0045
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0014 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.3994 0.5907 0.5907
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0056 0.0056
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.002 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0841 0.1227 0.1226
Echinococcus multilocularis Glutaredoxin protein 5 0.0062 0.007 0.0069
Echinococcus granulosus tachykinin peptides receptor 99D 0.036 0.0512 0.0512
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0046 0.0046 0.0045
Leishmania major peptidylprolyl isomerase-like protein 0.0053 0.0056 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.009 0.0089
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0062 0.007 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0062 0.007 0.1002
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.003 0.003
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0062 0.007 1
Toxoplasma gondii AGC kinase 0.0094 0.0118 0.0148
Echinococcus granulosus voltage gated potassium channel 0.0044 0.0043 0.0043
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0056 0.0056
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0436 0.0624 0.0624
Leishmania major protein kinase, putative 0.0021 0.0009 0.0009
Entamoeba histolytica hypothetical protein 0.0436 0.0624 0.0624
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0436 0.0624 0.0624
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0032 0.0025 0.0024
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2264 0.3339 0.3339
Trypanosoma cruzi heat shock protein 90, putative 0.0051 0.0054 0.0054
Schistosoma mansoni transcription factor LCR-F1 0.0028 0.002 0.002
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.6752 1 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0062 0.007 0.1002
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0069 0.008 0.008
Trypanosoma brucei cAMP response protein 1, putative 0.002 0.0008 0.0008
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0436 0.0624 0.0624
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2264 0.3339 0.3339
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0436 0.0624 0.0624
Echinococcus granulosus peptidase Clp S14 family 0.0041 0.0038 0.0037
Leishmania major phosphatidylinositol kinase related protein, putative 0.0436 0.0624 0.0624
Loa Loa (eye worm) phosphatidylinositol 3 0.0436 0.0624 0.0624
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1277 0.1873 0.1873
Plasmodium vivax heat shock protein 90, putative 0.0021 0.0009 0.0021
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0028 0.002 0.002
Giardia lamblia Kinase, AGC PKA 0.0063 0.0071 0.007
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0436 0.0624 0.0624
Trypanosoma cruzi heat shock protein 85, putative 0.0051 0.0054 0.0054
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.0043 0.0043
Mycobacterium ulcerans hypothetical protein 0.002 0.0008 0.1057
Schistosoma mansoni DNA polymerase eta 0.0035 0.003 0.003
Plasmodium vivax hypothetical protein, conserved 0.0436 0.0624 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.036 0.0512 0.0512
Onchocerca volvulus 0.0436 0.0624 1
Trypanosoma cruzi Flagellar Member 6 0.002 0.0008 0.0007
Entamoeba histolytica protein kinase 2, putative 0.0063 0.0071 0.007
Echinococcus multilocularis dna polymerase eta 0.0035 0.003 0.003
Loa Loa (eye worm) FKBP5 protein 0.0053 0.0056 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0021 0.0021
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0009 0.0009
Leishmania major heat shock protein 83-1 0.0051 0.0054 0.0054
Loa Loa (eye worm) heat shock protein 90 0.0051 0.0054 0.0054
Onchocerca volvulus 0.0436 0.0624 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5376 0.7958 0.7958
Brugia malayi Protein kinase domain containing protein 0.01 0.0127 0.0126
Mycobacterium tuberculosis Conserved protein 0.002 0.0008 0.0117
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0042 0.0041 0.004
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1277 0.1873 0.1873
Entamoeba histolytica hypothetical protein 0.0028 0.002 0.002
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0045 0.0045 0.0045
Trichomonas vaginalis fk506-binding protein, putative 0.0053 0.0056 0.0056
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.6752 1 1
Brugia malayi Hsp90 protein 0.0021 0.0009 0.0009
Entamoeba histolytica hypothetical protein 0.0028 0.002 0.002
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0053 0.0056 0.0056
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0032 0.0026 0.0026
Loa Loa (eye worm) phosphatidylinositol 3 0.0436 0.0624 0.0624
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0436 0.0624 0.0831
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0052 0.0055 0.0055
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0436 0.0624 0.0624
Mycobacterium tuberculosis Conserved hypothetical protein 0.0436 0.0624 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0062 0.007 0.0069
Leishmania major DNA polymerase eta, putative 0.0035 0.003 0.003
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0436 0.0624 0.0624
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0052 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0044 0.0043 0.0043
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.0008 0.0007
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0021 0.0009 0.0002
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0029 0.0021 0.0021
Trichomonas vaginalis AGC family protein kinase 0.01 0.0127 0.0126
Trypanosoma cruzi target of rapamycin kinase 3 0.5376 0.7958 0.7958
Echinococcus granulosus serine:threonine protein kinase N2 0.0032 0.0026 0.0026
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0436 0.0624 0.0624
Trypanosoma brucei heat shock protein, putative 0.0051 0.0054 0.0054
Echinococcus multilocularis fk506 binding protein 0.0053 0.0056 0.0056
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0053 0.0056 0.7883
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0436 0.0624 0.0624
Echinococcus multilocularis Zinc finger, PHD finger 0.0436 0.0624 0.0624
Echinococcus granulosus Protein kinase C brain isozyme 0.0032 0.0026 0.0026
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.6752 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0021 0.0021
Toxoplasma gondii FATC domain-containing protein 0.1277 0.1873 0.2513
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0026 0.0026
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2264 0.3339 0.3339
Entamoeba histolytica hypothetical protein 0.0028 0.002 0.002
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.002 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.537 0.7949 0.7949
Trichomonas vaginalis hypothetical protein 0.0027 0.0018 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0026 0.0026
Echinococcus multilocularis transcription factor Dp 1 0.003 0.0023 0.0022
Leishmania major phosphatidylinositol 3-kinase, putative 0.2264 0.3339 0.3339
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0436 0.0624 0.0624
Leishmania major phosphatidylinositol 4-kinase, putative 0.0436 0.0624 0.0624
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2264 0.3339 0.3339
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0021 0.0009 0.0269
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0045 0.0045 0.0045
Entamoeba histolytica PH domain containing protein kinase, putative 0.0069 0.008 0.008
Schistosoma mansoni voltage-gated potassium channel 0.0167 0.0225 0.0225
Loa Loa (eye worm) phosphatidylinositol 3 0.2264 0.3339 0.3339
Toxoplasma gondii Hsp90 domain-containing protein 0.0021 0.0009 0.0002
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0052 0.0055 0.0055
Echinococcus granulosus hyperpolarization activated cyclic 0.003 0.0023 0.0022
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0436 0.0624 0.0831
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0436 0.0624 1
Leishmania major heat shock protein 83-1 0.0051 0.0054 0.0054
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.002 0.0008 0.0007
Echinococcus multilocularis heat shock protein 90 0.0041 0.0038 0.0038
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.0008 0.0007
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0029 0.0021 0.0021
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0063 0.0071 0.007
Loa Loa (eye worm) phosphatidylinositol 3 0.0436 0.0624 0.0624
Leishmania major phosphatidylinositol kinase, putative 0.0436 0.0624 0.0624
Echinococcus granulosus heat shock protein 0.0051 0.0054 0.0054
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.003 0.0023 0.0022
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5376 0.7958 0.7958
Trypanosoma cruzi protein kinase A regulatory subunit 0.002 0.0008 0.0007
Entamoeba histolytica protein kinase rad3, putative 0.1277 0.1873 0.1873
Loa Loa (eye worm) hypothetical protein 0.1277 0.1873 0.1873
Schistosoma mansoni serine/threonine-protein kinase 0.0069 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0007
Loa Loa (eye worm) phosphatidylinositol kinase 0.0436 0.0624 0.0624
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0029 0.0021 0.0021
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0436 0.0624 0.0624
Leishmania major regulatory subunit of protein kinase a-like protein 0.002 0.0008 0.0007
Loa Loa (eye worm) AGC/AKT protein kinase 0.01 0.0127 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.1277 0.1873 0.1873
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0436 0.0624 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0029 0.0021 0.0021
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0052 0.0055 0.0055
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0436 0.0624 0.0624
Echinococcus multilocularis 0.0436 0.0624 0.0624
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0436 0.0624 0.0624
Trypanosoma cruzi Protein kinase B 0.0069 0.008 0.008
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0436 0.0624 0.0624
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1277 0.1873 0.1873
Trichomonas vaginalis PIKK family atypical protein kinase 0.3646 0.5389 0.5389
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0009 0.0009
Trichomonas vaginalis heat shock protein, putative 0.0041 0.0038 0.0038
Echinococcus granulosus serine threonine protein kinase nrc 0.0063 0.0071 0.007
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3193 0.4717 0.4717
Entamoeba histolytica serine/threonine protein kinase, putative 0.0075 0.009 0.0089
Leishmania major hypothetical protein, conserved 0.002 0.0008 0.0007
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.002 0.0008 0.0007
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2264 0.3339 0.3339
Loa Loa (eye worm) hypothetical protein 0.0032 0.0026 0.0026
Trypanosoma cruzi polo-like protein kinase, putative 0.0075 0.009 0.0089
Entamoeba histolytica PH domain containing protein kinase, putative 0.0069 0.008 0.008
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0021 0.0009 0.0021
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0052 0.0055 0.0055
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.6752 1 1
Echinococcus granulosus cGMP dependent protein kinase 1 0.0021 0.0009 0.0009
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0045 0.0045 0.0045
Trypanosoma brucei heat shock protein, putative 0.0051 0.0054 0.0054
Echinococcus multilocularis serine:threonine protein kinase 38 0.0032 0.0026 0.0026
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0026 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.4383 0.6484 0.6484
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0436 0.0624 0.0624
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2264 0.3339 0.3339
Echinococcus granulosus serine/threonine protein kinase 0.0069 0.008 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.003 0.0023 0.0022
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0436 0.0624 0.0624
Brugia malayi N-terminal motif family protein 0.002 0.0008 0.0007
Echinococcus multilocularis peptidase Clp (S14 family) 0.0041 0.0038 0.0037
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0029 0.0021 0.0021
Echinococcus granulosus transcription factor Dp 1 0.003 0.0023 0.0022
Echinococcus multilocularis serine:threonine protein kinase N2 0.0032 0.0026 0.0026
Trypanosoma cruzi heat shock protein 85, putative 0.0051 0.0054 0.0054
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0436 0.0624 0.0624
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0041 0.0038 0.0038
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0987 0.1443 0.1443
Leishmania major heat shock protein 83-1 0.0051 0.0054 0.0054
Schistosoma mansoni endoplasmin 0.0051 0.0054 0.0054
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0021 0.0009 0.0009
Plasmodium falciparum cGMP-dependent protein kinase 0.0021 0.0009 0.0023
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0053 0.0056 0.0056
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.0015 0.0009
Echinococcus multilocularis nervana 2 0.0062 0.007 0.0069
Echinococcus granulosus cyclic nucleotide gated cation channel 0.003 0.0023 0.0022
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.002 0.0008 0.0117
Trypanosoma brucei cAMP binding protein, putative 0.002 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0075 0.0089 0.0088
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0053 0.0056 0.0056
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0436 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0055 0.0059 0.0059
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0041 0.0038 0.0601
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0026 0.0026
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0436 0.0624 0.0624
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.0008 0.0007
Toxoplasma gondii heat shock protein 75, putative 0.0021 0.0009 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.537 0.7949 0.7949
Trichomonas vaginalis PIKK family atypical protein kinase 0.1277 0.1873 0.1873
Loa Loa (eye worm) hypothetical protein 0.0133 0.0175 0.0174
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0436 0.0624 0.0624
Schistosoma mansoni heat shock protein 0.0021 0.0009 0.0009
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0075 0.009 0.0089
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0436 0.0624 0.0624
Entamoeba histolytica hypothetical protein 0.1277 0.1873 0.1873
Trichomonas vaginalis immunophilin, putative 0.0053 0.0056 0.0056
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0053 0.0056 0.0056
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.002 0.0008 0.0117
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0436 0.0624 0.0624
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0041 0.0038 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.4529 0.67 0.67
Trichomonas vaginalis PIKK family atypical protein kinase 0.5022 0.7432 0.7432
Giardia lamblia Hypothetical protein 0.0436 0.0624 0.0624
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0153 0.0204 0.0204
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0029 0.0021 0.0021
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0063 0.0071 0.007
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1423 0.209 0.2805
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0053 0.0056 0.079
Trichomonas vaginalis conserved hypothetical protein 0.0987 0.1443 0.1443
Echinococcus multilocularis hyperpolarization activated cyclic 0.003 0.0023 0.0022
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0436 0.0624 0.0624
Echinococcus granulosus protein kinase c iota type 0.0032 0.0026 0.0026
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0436 0.0624 0.0624
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1277 0.1873 0.1873
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0021 0.0009 0.0009
Trichomonas vaginalis heat shock protein, putative 0.0041 0.0038 0.0038
Echinococcus granulosus patatin phospholipase domain containing protein 0.002 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.6752 1 1
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0026 0.0026
Leishmania major hypothetical protein, unknown function 0.0436 0.0624 0.0624
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.009 0.0089
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0053 0.0056 0.0056
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0075 0.009 0.0089
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0436 0.0624 0.0624
Leishmania major heat shock protein 83-1 0.0051 0.0054 0.0054
Mycobacterium ulcerans regulatory protein 0.002 0.0008 0.1057
Entamoeba histolytica protein kinase, putative 0.01 0.0127 0.0126
Leishmania major heat shock protein 83-1 0.0051 0.0054 0.0054
Leishmania major protein kinase, putative 0.0021 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.1423 0.209 0.209
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0026 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.5022 0.7432 0.7432
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.009 0.0089
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0436 0.0624 0.0624
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0436 0.0624 0.0624
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.003 0.0023 0.0022
Loa Loa (eye worm) AGC/PKN protein kinase 0.0032 0.0026 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0026 0.0026
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0436 0.0624 0.0624
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0436 0.0624 0.0624
Schistosoma mansoni endoplasmin 0.0051 0.0054 0.0054
Echinococcus granulosus dna polymerase eta 0.0035 0.003 0.003
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0021 0.0009 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.5022 0.7432 0.7432
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0436 0.0624 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.2 uM Inhibition of [125I]-[MePhe]-NKB binding to human Tachykinin receptor 3 in CHO cells ChEMBL. No reference
IC50 (binding) = 5.2 uM Inhibition of [125I]-[MePhe]-NKB binding to human Tachykinin receptor 3 in CHO cells ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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