Detailed information for compound 158887

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 426.939 | Formula: C23H27ClN4O2
  • H donors: 2 H acceptors: 2 LogP: 3.76 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1CCCC(C1)NCc1n[nH]c(c1)/C=C/c1cn(c2c1cc(Cl)cc2)C
  • InChi: 1S/C23H27ClN4O2/c1-28-14-16(21-11-17(24)7-9-22(21)28)6-8-19-12-20(27-26-19)13-25-18-5-3-4-15(10-18)23(29)30-2/h6-9,11-12,14-15,18,25H,3-5,10,13H2,1-2H3,(H,26,27)/b8-6+
  • InChiKey: SITXHAVZQRLLMP-SOFGYWHQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli DNA gyrase (type II topoisomerase), subunit A Starlite/ChEMBL References
Escherichia coli DNA gyrase, subunit B References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Babesia bovis DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium vivax DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Leishmania infantum mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium falciparum DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) Get druggable targets OG5_128755 All targets in OG5_128755
Babesia bovis DNA gyrase A subunit, putative Get druggable targets OG5_129568 All targets in OG5_129568
Treponema pallidum DNA gyrase, subunit B (gyrB) Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium knowlesi DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium yoelii DNA gyrase subunit a-related Get druggable targets OG5_129568 All targets in OG5_129568
Trypanosoma brucei DNA topoisomerase ii Get druggable targets OG5_128755 All targets in OG5_128755
Mycobacterium ulcerans DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium falciparum DNA gyrase subunit B Get druggable targets OG5_128755 All targets in OG5_128755
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) Get druggable targets OG5_128755 All targets in OG5_128755
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium yoelii DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania braziliensis mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Chlamydia trachomatis DNA gyrase subunit B Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania major mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Chlamydia trachomatis DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium berghei DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium knowlesi DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Neospora caninum hypothetical protein Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium berghei DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Neospora caninum DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium vivax DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) Get druggable targets OG5_129568 All targets in OG5_129568
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania donovani mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Theileria parva DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania mexicana mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Treponema pallidum DNA gyrase, subunit A (gyrA) Get druggable targets OG5_129568 All targets in OG5_129568
Trypanosoma congolense DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Mycobacterium ulcerans DNA gyrase subunit B Get druggable targets OG5_128755 All targets in OG5_128755
Theileria parva DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma brucei gambiense DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0125 0.0698 0.2591
Brugia malayi AMP-binding enzyme family protein 0.0042 0.019 0.0233
Onchocerca volvulus 0.0015 0.0021 0.0015
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0144 0.0817 0.0832
Echinococcus granulosus neuropeptide receptor A26 0.0366 0.2182 0.4174
Brugia malayi Carboxylesterase family protein 0.0275 0.162 0.1996
Brugia malayi hypothetical protein 0.0052 0.0251 0.0309
Brugia malayi endonuclease G, mitochondrial precursor 0.002 0.005 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0129 0.0989
Brugia malayi cytoplasmic intermediate filament protein 0.0013 0.0008 0.0008
Toxoplasma gondii cytochrome c, putative 0.0033 0.0134 0.0482
Loa Loa (eye worm) pax transcription factor protein 2 0.1329 0.8109 1
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0027 0.0177
Loa Loa (eye worm) hypothetical protein 0.0024 0.0074 0.0091
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0027 0.0052
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0065 0.033 0.0631
Loa Loa (eye worm) hypothetical protein 0.01 0.0543 0.067
Onchocerca volvulus 0.0071 0.0364 0.0359
Leishmania major cathepsin L-like protease 0.0057 0.0279 0.1025
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0027 0.0118
Brugia malayi Thioredoxin reductase 0.0046 0.0214 0.0262
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0129 0.0246
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0021 0.0122
Loa Loa (eye worm) glutathione reductase 0.0046 0.0214 0.0264
Loa Loa (eye worm) cytochrome c type-1 0.0099 0.0537 0.0662
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0033 0.0054
Echinococcus granulosus cathepsin L cysteine proteinase 0.0015 0.0021 0.0039
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0033 0.0064
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0054 0.0262 0.0502
Schistosoma mansoni smad1 5 8 and 0.0033 0.0129 0.0236
Trichomonas vaginalis inositol monophosphatase, putative 0.0026 0.0089 0.0666
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0015 0.0021 0.0025
Loa Loa (eye worm) inositol-1 0.0026 0.0089 0.011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0021 0.0122
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0125 0.0698 0.2591
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0652 0.3444
Onchocerca volvulus 0.0015 0.0021 0.0015
Echinococcus multilocularis GPCR, family 2 0.01 0.0543 0.0553
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0077 0.0402 0.0768
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0028 0.0098 0.0188
Trypanosoma brucei trypanothione reductase 0.0046 0.0214 0.0781
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0279 0.1025
Plasmodium falciparum DNA gyrase subunit B 0.0153 0.0869 0.3231
Loa Loa (eye worm) hypothetical protein 0.0025 0.0081 0.01
Echinococcus multilocularis carboxylesterase 5A 0.0275 0.162 0.1649
Onchocerca volvulus 0.0024 0.0077 0.0072
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0089 0.0313
Brugia malayi glutathione reductase 0.0046 0.0214 0.0262
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0129 0.0159
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0113 0.0574
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0026 0.0089 0.0666
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0251 0.0921
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.013 0.0249
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.002 0.005 0.0166
Toxoplasma gondii hypothetical protein 0.0043 0.0194 0.0705
Schistosoma mansoni troponin t invertebrate 0.0144 0.0817 0.1555
Onchocerca volvulus Cathepsin L homolog 0.0015 0.0021 0.0015
Schistosoma mansoni smad1 5 8 and 0.0033 0.0129 0.0236
Trypanosoma cruzi cruzipain precursor, putative 0.0057 0.0279 0.1025
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.002 0.005 0.0166
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0214 0.04
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0037 0.0046
Loa Loa (eye worm) hypothetical protein 0.0038 0.0165 0.0203
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0048
Mycobacterium tuberculosis Carboxylesterase LipT 0.0046 0.0214 0.1112
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0062 0.0312 0.0318
Echinococcus granulosus ectonucleotide 0.0028 0.0098 0.0188
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0026 0.0089 0.0331
Echinococcus multilocularis cathepsin L cysteine protease 0.0015 0.0021 0.0021
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0027 0.0028
Loa Loa (eye worm) hypothetical protein 0.0046 0.0214 0.0264
Brugia malayi MH1 domain containing protein 0.0018 0.0039 0.0047
Trypanosoma cruzi major cysteine proteinase, putative 0.0045 0.0204 0.0744
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0073 0.0075
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0021 0.0142
Loa Loa (eye worm) carboxylesterase 0.0046 0.0214 0.0264
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0021 0.0024
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0065 0.033 0.1215
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0082 0.0433 0.2276
Schistosoma mansoni cathepsin F (C01 family) 0.0015 0.0021 0.0029
Loa Loa (eye worm) cysteine protease 0.0015 0.0021 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0113 0.0574
Echinococcus multilocularis lamin 0.0024 0.0077 0.0078
Leishmania major trypanothione reductase 0.0046 0.0214 0.0781
Brugia malayi MH1 domain containing protein 0.0018 0.0039 0.0047
Trypanosoma cruzi DNA topoisomerase II, putative 0.0058 0.0284 0.1043
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0033 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0021 0.0122
Brugia malayi Troponin T 0.0069 0.0353 0.0435
Loa Loa (eye worm) hypothetical protein 0.0071 0.0364 0.0448
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0067 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.0083
Brugia malayi Cytochrome c type-1 0.0099 0.0537 0.0661
Plasmodium falciparum glutathione reductase 0.0046 0.0214 0.0781
Loa Loa (eye worm) hypothetical protein 0.0024 0.0077 0.0095
Trypanosoma brucei telomerase reverse transcriptase 0.0447 0.2679 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0021 0.0122
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0027 0.0083
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0214 0.0218
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.002 0.005 0.0166
Leishmania major cytochrome c, putative 0.0099 0.0537 0.1988
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0021 0.0122
Chlamydia trachomatis DNA gyrase subunit A 0.0033 0.0132 0.0561
Echinococcus granulosus BC026374 protein S09 family 0.0046 0.0214 0.041
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0214 0.04
Echinococcus multilocularis Smad4 0.0033 0.0129 0.0131
Plasmodium falciparum thioredoxin reductase 0.0016 0.0027 0.0083
Brugia malayi 'Paired box' domain containing protein 0.0025 0.0085 0.0104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0021 0.0122
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.0018 0.0018
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0027 0.0083
Plasmodium falciparum cytochrome c, putative 0.0033 0.0134 0.0482
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0318 0.1884 0.7028
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.0083
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0105
Echinococcus granulosus paired box gene 3/7 (eyeless, eyegone, twin of eyeless) 0.0025 0.0085 0.0163
Loa Loa (eye worm) hypothetical protein 0.0043 0.0191 0.0235
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0033 0.013 0.0239
Trypanosoma cruzi DNA topoisomerase II, putative 0.0058 0.0284 0.1043
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.013 0.0132
Leishmania major cathepsin L-like protease 0.0015 0.0021 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0021 0.0122
Loa Loa (eye worm) TOPoisomerase family member 0.0069 0.0351 0.0433
Echinococcus granulosus chromobox protein 1 0.0058 0.0287 0.0549
Echinococcus granulosus para nitrobenzyl esterase 0.0046 0.0214 0.041
Brugia malayi Cathepsin L-like precursor 0.0015 0.0021 0.0024
Loa Loa (eye worm) heterochromatin protein 1 0.0058 0.0287 0.0354
Loa Loa (eye worm) hypothetical protein 0.0032 0.0124 0.0153
Echinococcus multilocularis chromobox protein 1 0.0058 0.0287 0.0292
Toxoplasma gondii aldehyde dehydrogenase 0.0054 0.0262 0.0962
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0035 0.0145 0.014
Leishmania major cathepsin L-like protease 0.0057 0.0279 0.1025
Onchocerca volvulus 0.0015 0.0021 0.0015
Loa Loa (eye worm) acetylcholinesterase 1 0.0275 0.162 0.1997
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0021 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0071 0.0522
Brugia malayi Probable ClpP-like protease 0.0125 0.0698 0.086
Plasmodium vivax vivapain-2 0.0015 0.0021 0.0057
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0015 0.0021 0.0021
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.013 0.0249
Echinococcus granulosus troponin i 0.0116 0.0645 0.1234
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0065 0.033 0.1215
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0015 0.0021 0.0122
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.058 0.3057
Brugia malayi AMP-binding enzyme family protein 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0032 0.0124 0.0153
Loa Loa (eye worm) hypothetical protein 0.0046 0.0214 0.0264
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0018 0.0021
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0129 0.0236
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0162
Schistosoma mansoni chromobox protein 0.0058 0.0287 0.0539
Plasmodium vivax DNA topoisomerase II, putative 0.0069 0.0351 0.1295
Loa Loa (eye worm) hypothetical protein 0.0033 0.0129 0.016
Brugia malayi AMP-binding enzyme family protein 0.0042 0.019 0.0233
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0026 0.0089 0.0445
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0077 0.0402 0.0409
Echinococcus multilocularis paired box protein pax 6 0.0025 0.0085 0.0087
Echinococcus granulosus cytochrome c 0.0099 0.0537 0.1027
Schistosoma mansoni lamin 0.0024 0.0077 0.0137
Echinococcus granulosus GPCR family 2 0.01 0.0543 0.1039
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0501 0.3946
Brugia malayi Carboxylesterase family protein 0.0046 0.0214 0.0263
Leishmania major endonuclease G, putative 0.002 0.005 0.0166
Loa Loa (eye worm) hypothetical protein 0.0015 0.0018 0.0022
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0188 0.1085 0.2074
Loa Loa (eye worm) nuclear factor I 0.0018 0.0039 0.0048
Echinococcus granulosus lamin dm0 0.0024 0.0077 0.0147
Loa Loa (eye worm) hypothetical protein 0.0046 0.0214 0.0264
Echinococcus multilocularis smad 0.0033 0.0129 0.0131
Schistosoma mansoni neuroligin 3 (S09 family) 0.0046 0.0214 0.04
Brugia malayi Carboxylesterase family protein 0.0046 0.0214 0.0263
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.058 0.3057
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0042 0.019 0.0983
Brugia malayi vab-3 gene. 0.0025 0.0085 0.0104
Echinococcus multilocularis cathepsin L cysteine protease 0.0015 0.0021 0.0021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.019 0.0983
Brugia malayi Troponin T 0.0069 0.0353 0.0435
Trichomonas vaginalis spcc417.12 protein, putative 0.0046 0.0214 0.1664
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0447 0.2679 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0214 0.04
Schistosoma mansoni endonuclease related 0.002 0.005 0.0085
Echinococcus granulosus carboxylesterase 5A 0.0275 0.162 0.3098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0006
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0027 0.0083
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0125 0.0698 0.3687
Brugia malayi hypothetical protein 0.0613 0.3699 0.4561
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0153 0.0869 0.4533
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0033 0.013 0.0239
Echinococcus multilocularis troponin i 0.0116 0.0645 0.0657
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0279 0.1025
Schistosoma mansoni hypothetical protein 0.0062 0.0312 0.0588
Entamoeba histolytica hypothetical protein 0.0062 0.0312 0.2847
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.01 0.0543 0.0669
Leishmania major cathepsin L-like protease 0.0015 0.0021 0.0057
Brugia malayi Bromodomain containing protein 0.0038 0.0164 0.0201
Echinococcus granulosus inositol monophosphatase 1 0.0026 0.0089 0.017
Entamoeba histolytica cysteine protease, putative 0.0015 0.0021 0.0142
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.058 0.3057
Echinococcus granulosus chromobox protein 1 0.0058 0.0287 0.0549
Echinococcus granulosus neuroligin 0.0046 0.0214 0.041
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0105
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0054 0.0262 0.0267
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0033 0.0054
Loa Loa (eye worm) carboxylesterase 0.0046 0.0214 0.0264
Onchocerca volvulus 0.1329 0.8109 0.8108
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0065 0.033 0.1729
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0027 0.0083
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1608 0.9822 1
Onchocerca volvulus 0.0033 0.013 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0021 0.0122
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0088 0.0472 0.1746
Schistosoma mansoni Smad4 0.0015 0.0018 0.0024
Echinococcus multilocularis lamin dm0 0.0024 0.0077 0.0078
Onchocerca volvulus Cathepsin F homolog 0.0015 0.0021 0.0015
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0062 0.0312 0.0598
Echinococcus multilocularis inositol monophosphatase 1 0.0026 0.0089 0.009
Schistosoma mansoni acetylcholinesterase 0.0046 0.0214 0.04
Echinococcus multilocularis neuropeptide s receptor 0.0366 0.2182 0.2222
Toxoplasma gondii isocitrate dehydrogenase 0.0065 0.033 0.1215
Leishmania major telomerase reverse transcriptase, putative 0.0447 0.2679 1
Echinococcus granulosus cathepsin l1 0.0015 0.0021 0.0039
Onchocerca volvulus 0.0015 0.0021 0.0015
Schistosoma mansoni hypothetical protein 0.01 0.0543 0.103
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.002 0.005 0.0166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0021 0.0122
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0105
Brugia malayi Troponin family protein 0.0116 0.0645 0.0794
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0027 0.0083
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0021 0.0122
Brugia malayi Thrombospondin type 1 domain containing protein 0.0071 0.0364 0.0447
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0058 0.0287 0.2612
Brugia malayi Calcitonin receptor-like protein seb-1 0.0316 0.1872 0.2307
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.0018 0.0018
Brugia malayi Cathepsin L-like precursor 0.0015 0.0021 0.0024
Echinococcus multilocularis acetylcholinesterase 0.0275 0.162 0.1649
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0125 0.0698 0.0711
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0188 0.1085 0.4036
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0027 0.0118
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0188 0.1085 0.1104
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0125 0.0698 0.3612
Leishmania major 4-coumarate:coa ligase-like protein 0.0042 0.019 0.0691
Onchocerca volvulus Troponin I homolog 0.0116 0.0645 0.064
Echinococcus multilocularis zinc finger protein 0.002 0.0049 0.005
Plasmodium falciparum acyl-CoA synthetase 0.0032 0.0124 0.0443
Schistosoma mansoni BC026374 protein (S09 family) 0.0046 0.0214 0.04
Trypanosoma cruzi polo-like protein kinase, putative 0.0188 0.1085 0.4036
Schistosoma mansoni paired box protein pax-6 0.0025 0.0085 0.0153
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0251 0.0921
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0024 0.0077 0.0095
Schistosoma mansoni chromobox protein 0.0058 0.0287 0.0539
Toxoplasma gondii isocitrate dehydrogenase 0.0065 0.033 0.1215
Brugia malayi Carboxylesterase family protein 0.0046 0.0214 0.0263
Loa Loa (eye worm) intermediate filament protein 0.0024 0.0077 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0279 0.1025
Loa Loa (eye worm) hypothetical protein 0.0033 0.013 0.016
Loa Loa (eye worm) isocitrate dehydrogenase 0.0065 0.033 0.0407
Trypanosoma brucei ISWI complex protein 0.0015 0.0023 0.0065
Plasmodium vivax vivapain-2 0.0015 0.0021 0.0057
Schistosoma mansoni troponin I 0.0116 0.0645 0.1225
Loa Loa (eye worm) hypothetical protein 0.0116 0.0645 0.0795
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0058 0.0287 0.2612
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0018 0.0022
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0043 0.0194 0.0895
Loa Loa (eye worm) hypothetical protein 0.0025 0.0081 0.01
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0125 0.0698 0.3612
Schistosoma mansoni smad 0.0033 0.0129 0.0236
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.0083
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0113 0.0574
Plasmodium falciparum DNA gyrase subunit A 0.0318 0.1884 0.7028
Loa Loa (eye worm) hypothetical protein 0.0483 0.2901 0.3577
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0152 0.0861 1
Echinococcus multilocularis cytochrome c 0.0099 0.0537 0.0547
Echinococcus multilocularis Endonuclease G 0.002 0.005 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0279 0.1025
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0065 0.033 0.1215
Leishmania major cathepsin L-like protease 0.0015 0.0021 0.0057
Brugia malayi isocitrate dehydrogenase 0.0065 0.033 0.0406
Brugia malayi Cathepsin L-like precursor 0.0015 0.0021 0.0024
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0065 0.033 0.1215
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0077 0.0402 0.0759
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0214 0.1112
Schistosoma mansoni kinase 0.0095 0.0516 0.0978
Schistosoma mansoni hypothetical protein 0.0071 0.0364 0.0686
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0027 0.0083
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0214 0.0264
Giardia lamblia DNA topoisomerase II 0.0064 0.0322 0.111
Leishmania major cytochrome c, putative 0.0099 0.0537 0.1988
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0027 0.0083
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0251 0.0921
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0214 0.1112
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0012 0.0005 0.0005
Onchocerca volvulus Cathepsin L homolog 0.0015 0.0021 0.0015
Schistosoma mansoni hypothetical protein 0.0024 0.0073 0.013
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.013 0.0132
Schistosoma mansoni hypothetical protein 0.0861 0.5229 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0065 0.033 0.1215
Echinococcus granulosus geminin 0.0861 0.5229 1
Brugia malayi Troponin I 0.0116 0.0645 0.0794
Schistosoma mansoni hypothetical protein 0.0216 0.1257 0.2396
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.019 0.0983
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.01 0.0543 0.1039
Onchocerca volvulus 0.0015 0.0021 0.0015
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0027 0.0083
Brugia malayi Carboxylesterase family protein 0.0046 0.0214 0.0263
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.0021 0.0057
Mycobacterium ulcerans aldehyde dehydrogenase 0.0054 0.0262 0.1369
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0121 0.0675 0.2506
Schistosoma mansoni aldehyde dehydrogenase 0.0054 0.0262 0.0492
Toxoplasma gondii thioredoxin reductase 0.0046 0.0214 0.0781
Schistosoma mansoni hypothetical protein 0.0861 0.5229 1
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0214 0.0781
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0027 0.0032
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0015 0.0021 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.1085 0.8596
Onchocerca volvulus 0.0042 0.019 0.0185
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.0083
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0027 0.0083
Brugia malayi MH2 domain containing protein 0.0033 0.0129 0.0157
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0214 0.0409
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0055 0.0068
Echinococcus granulosus neuropeptide s receptor 0.0366 0.2182 0.4174
Loa Loa (eye worm) latrophilin receptor protein 2 0.01 0.0543 0.067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0021 0.0122
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0129 0.0131
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0023 0.0072 0.0781
Brugia malayi AMP-binding enzyme family protein 0.0012 0.0005 0.0005
Toxoplasma gondii cathepsin CPL 0.0015 0.0021 0.0057
Loa Loa (eye worm) hypothetical protein 0.0275 0.162 0.1997
Mycobacterium leprae Probable Ubiquinol-cytochrome C reductase QcrC (cytochrome C subunit) 0.0033 0.0134 0.1506
Brugia malayi Cathepsin L-like precursor 0.0015 0.0021 0.0024
Brugia malayi AMP-binding enzyme family protein 0.0042 0.019 0.0233
Loa Loa (eye worm) hypothetical protein 0.0041 0.0179 0.0221
Entamoeba histolytica hypothetical protein 0.0062 0.0312 0.2847
Brugia malayi MH2 domain containing protein 0.0015 0.0018 0.0021
Plasmodium falciparum glutathione reductase 0.0016 0.0027 0.0083
Schistosoma mansoni inositol monophosphatase 0.0026 0.0089 0.016
Trichomonas vaginalis chromobox protein, putative 0.0058 0.0287 0.2243
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0043 0.0194 0.2202
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0065 0.033 0.0336
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.1085 0.8596
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0043 0.0194 0.0705
Onchocerca volvulus Retinal homeobox protein Rx homolog 0.0025 0.0085 0.008
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0054 0.0262 0.0962
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0069 0.0351 0.0672
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.013 0.0249
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0125 0.0698 0.3612
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0279 0.1025
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0065 0.033 0.0336
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0042 0.019 0.2158
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0125 0.0698 0.2591
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0082 0.0433 0.4999
Brugia malayi Intermediate filament tail domain containing protein 0.0024 0.0077 0.0093
Toxoplasma gondii RNA-directed DNA polymerase 0.0447 0.2679 1
Trypanosoma cruzi cysteine peptidase, putative 0.0057 0.0279 0.1025
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0033 0.013 0.0239
Plasmodium falciparum cytochrome c, putative 0.0099 0.0537 0.1988
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0082 0.0433 0.2276
Brugia malayi Heterochromatin protein 1 0.0058 0.0287 0.0352
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0113 0.0574
Trypanosoma brucei endonuclease G, putative 0.002 0.005 0.0166
Schistosoma mansoni gliotactin 0.0046 0.0214 0.04
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0065 0.033 0.0336
Brugia malayi Gooseberry protein 0.0025 0.0085 0.0104
Leishmania major cathepsin L-like protease 0.0057 0.0279 0.1025
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0318 0.1884 1
Loa Loa (eye worm) oxidoreductase 0.0012 0.0005 0.0006
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0089 0.0313
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.01 0.0543 0.0553
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0073 0.014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0054 0.0262 0.1369
Leishmania major DNA topoisomerase ii 0.0058 0.0284 0.1043
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0026 0.0089 0.0313
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.0018 0.0034
Echinococcus granulosus cathepsin l cysteine peptidase 0.0015 0.0021 0.0039
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0121 0.0675 0.2506
Plasmodium vivax telomerase reverse transcriptase, putative 0.0447 0.2679 1
Onchocerca volvulus 0.0046 0.0214 0.0209
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0129 0.0246
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0279 0.1025
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0316 0.1872 0.2308
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0021 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0077 0.0402 0.0759
Trypanosoma brucei DNA topoisomerase ii 0.0121 0.0675 0.2506
Schistosoma mansoni cathepsin F (C01 family) 0.0015 0.0021 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0021 0.0122
Onchocerca volvulus 0.0046 0.0214 0.0209
Brugia malayi Telomerase reverse transcriptase 0.119 0.7249 0.8939
Echinococcus granulosus Endonuclease G 0.002 0.005 0.0095
Onchocerca volvulus 0.0024 0.0077 0.0072
Mycobacterium tuberculosis Probable reductase 0.0106 0.058 0.3057
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0058 0.0284 0.1043
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0129 0.0131
Plasmodium falciparum telomerase reverse transcriptase 0.0447 0.2679 1
Plasmodium vivax cytochrome c, putative 0.0033 0.0134 0.0482
Schistosoma mansoni zinc finger protein 0.0015 0.0023 0.0033
Schistosoma mansoni DNA topoisomerase II 0.0069 0.0351 0.0663
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0069 0.0351 0.0432
Loa Loa (eye worm) hypothetical protein 0.0116 0.0645 0.0795
Loa Loa (eye worm) MH2 domain-containing protein 0.0478 0.2867 0.3536
Plasmodium vivax DNA gyrase subunit A, putative 0.0318 0.1884 0.7028
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0067 0.0128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0279 0.1025
Loa Loa (eye worm) hypothetical protein 0.0032 0.0124 0.0153
Plasmodium falciparum thioredoxin reductase 0.0046 0.0214 0.0781
Echinococcus granulosus smad 0.0033 0.0129 0.0246
Trypanosoma brucei cytochrome c 0.0099 0.0537 0.1988
Trypanosoma cruzi cytochrome c, putative 0.0099 0.0537 0.1988
Onchocerca volvulus 0.0025 0.0085 0.008
Brugia malayi MH1 domain containing protein 0.0033 0.0129 0.0157
Trichomonas vaginalis chromobox protein, putative 0.0058 0.0287 0.2243
Plasmodium vivax DNA gyrase subunit B, putative 0.0153 0.0869 0.3231
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0027 0.0118
Echinococcus multilocularis neuroligin 0.0046 0.0214 0.0218
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0046 0.0214 0.1664
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0015 0.0021 0.0057
Schistosoma mansoni inositol monophosphatase 0.0026 0.0089 0.016
Mycobacterium ulcerans DNA gyrase subunit B 0.0153 0.0869 0.4598
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0021 0.0122
Loa Loa (eye worm) hypothetical protein 0.0216 0.1257 0.155
Schistosoma mansoni Smad4 0.0033 0.0129 0.0236
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0077 0.0402 0.0768
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0042 0.019 0.0983
Schistosoma mansoni smad 0.0015 0.0018 0.0024
Toxoplasma gondii cytochrome c, putative 0.0099 0.0537 0.1988
Toxoplasma gondii DNA topoisomerase 2, putative 0.0069 0.0351 0.1295
Schistosoma mansoni troponin I 0.0116 0.0645 0.1225
Brugia malayi hypothetical protein 0.0034 0.0137 0.0168
Onchocerca volvulus 0.0015 0.0021 0.0015
Schistosoma mansoni bromodomain containing protein 0.0063 0.0318 0.0598
Mycobacterium ulcerans DNA gyrase subunit A 0.0318 0.1884 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0042 0.019 0.1711
Brugia malayi Cathepsin L-like precursor 0.0015 0.0021 0.0024
Schistosoma mansoni troponin I 0.0116 0.0645 0.1225
Echinococcus multilocularis neuropeptide receptor A26 0.0366 0.2182 0.2222
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0069 0.0351 0.0346
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0032 0.0124 0.0631
Trichomonas vaginalis chromobox protein, putative 0.0035 0.0145 0.111
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0027 0.0083
Brugia malayi MH1 domain containing protein 0.0033 0.0129 0.0157
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0053 0.0252 0.2888
Loa Loa (eye worm) glutaminase 2 0.0217 0.1261 0.1555
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0318 0.1884 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0018 0.0022
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0021 0.0142
Giardia lamblia Kinase, PLK 0.0188 0.1085 0.3986
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0153 0.0869 0.4598
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.013 0.0132
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0043 0.0194 0.0705
Schistosoma mansoni smad1 5 8 and 0.0033 0.0129 0.0236
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0027 0.0083
Echinococcus multilocularis ectonucleotide 0.0028 0.0098 0.01
Echinococcus multilocularis para nitrobenzyl esterase 0.0046 0.0214 0.0218
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0042 0.019 0.2158
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0296 0.0566
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0089 0.0313
Trypanosoma cruzi ISWI complex protein 0.0015 0.0023 0.0065
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0065 0.033 0.1215
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0652 0.3444
Echinococcus multilocularis acetylcholinesterase 0.0275 0.162 0.1649
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0071 0.0364 0.0449
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0012 0.0005 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.0083
Schistosoma mansoni hypothetical protein 0.0015 0.0023 0.0033
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0125 0.0698 0.1335
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.015 0.0152
Echinococcus multilocularis paired box protein pax 6 0.0025 0.0085 0.0087
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0027 0.0118
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0214 0.1111
Brugia malayi Pax transcription factor protein 2 0.1329 0.8109 1
Trypanosoma cruzi ISWI complex protein 0.0015 0.0023 0.0065
Echinococcus multilocularis BC026374 protein (S09 family) 0.0046 0.0214 0.0218
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0042 0.019 0.0983
Echinococcus multilocularis chromobox protein 1 0.0058 0.0287 0.0292
Brugia malayi PHD-finger family protein 0.0025 0.0082 0.0099
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0046 0.0214 0.041
Echinococcus multilocularis paired box protein pax 1 0.0025 0.0085 0.0087
Brugia malayi Inositol-1 0.0026 0.0089 0.0108
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0027 0.0083
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0105
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0069 0.0351 0.0346
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0032 0.0124 0.0631
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0279 0.1025
Plasmodium falciparum DNA topoisomerase 2 0.0069 0.0351 0.1295
Echinococcus granulosus lamin 0.0024 0.0077 0.0147
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0251 0.0921
Onchocerca volvulus 0.0046 0.0214 0.0209
Loa Loa (eye worm) hypothetical protein 0.0275 0.162 0.1997
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.058 0.3057
Leishmania major cathepsin L-like protease 0.0015 0.0021 0.0057
Loa Loa (eye worm) troponin T 0.0069 0.0353 0.0436
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0015 0.0018 0.0013
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0188 0.1085 0.1337
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.013 0.0132
Loa Loa (eye worm) hypothetical protein 0.0033 0.013 0.016
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0125 0.0698 0.8099
Entamoeba histolytica acyl-CoA synthetase, putative 0.0042 0.019 0.1711
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0251 0.0921
Leishmania major mitochondrial DNA topoisomerase II 0.0121 0.0675 0.2506
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.1085 0.8596
Mycobacterium ulcerans carboxylesterase, LipT 0.0046 0.0214 0.1112
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0483 0.2901 0.3576
Echinococcus granulosus peptidase Clp S14 family 0.0082 0.0433 0.0828
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0033 0.013 0.016
Onchocerca volvulus 0.0026 0.0086 0.0081
Mycobacterium ulcerans ubiquinol-cytochrome C reductase QcrC 0.0033 0.0134 0.0686
Loa Loa (eye worm) hypothetical protein 0.0042 0.019 0.0234
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0067 0.0068
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0028 0.0098 0.01
Brugia malayi Bromodomain containing protein 0.0075 0.039 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0021 0.0122
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0652 0.3444
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0279 0.1025
Echinococcus granulosus intermediate filament protein 0.0024 0.0077 0.0147
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0013 0.0008 0.001
Brugia malayi hypothetical protein 0.0069 0.0353 0.0435
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0033 0.0129 0.0124
Loa Loa (eye worm) hypothetical protein 0.0188 0.1083 0.1335
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0021 0.0122
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0021 0.0122
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0033 0.0054
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.019 0.0983
Schistosoma mansoni hypothetical protein 0.01 0.0543 0.103
Loa Loa (eye worm) hypothetical protein 0.0058 0.0287 0.0354
Brugia malayi hypothetical protein 0.0046 0.0214 0.0263
Schistosoma mansoni Smad4 0.0015 0.0018 0.0024
Schistosoma mansoni hypothetical protein 0.01 0.0543 0.103
Brugia malayi Smad1 0.0033 0.0129 0.0157
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0214 0.0781
Mycobacterium ulcerans hypothetical protein 0.0042 0.019 0.0983
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0052 0.0249 0.0911
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.015 0.0286
Trypanosoma brucei endonuclease G, putative 0.002 0.005 0.0166
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0275 0.162 0.3091
Leishmania major 4-coumarate:coa ligase-like protein 0.0042 0.019 0.0691
Trichomonas vaginalis chromobox protein, putative 0.0035 0.0145 0.111
Echinococcus multilocularis cysteine protease 0.0015 0.0021 0.0021
Giardia lamblia Telomerase catalytic subunit 0.0447 0.2679 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0279 0.1025
Trypanosoma cruzi cytochrome c, putative 0.0099 0.0537 0.1988
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0042 0.019 0.0983
Loa Loa (eye worm) hypothetical protein 0.0028 0.0098 0.0121
Chlamydia trachomatis DNA gyrase subunit B 0.01 0.0545 0.2789
Schistosoma mansoni troponin I 0.0116 0.0645 0.1225
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0005 0.0005
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0129 0.0159
Trypanosoma brucei endonuclease G, putative 0.002 0.005 0.0166
Trypanosoma cruzi cysteine peptidase, putative 0.0057 0.0279 0.1025
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0033 0.013 0.0159
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0089 0.0313
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0027 0.0083
Leishmania major 4-coumarate:coa ligase-like protein 0.0042 0.019 0.0691
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0027 0.0042
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0188 0.1083 0.1078
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0033 0.0034
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0033 0.0054
Entamoeba histolytica serine/threonine protein kinase, putative 0.0188 0.1085 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0124 0.0153
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0077 0.0402 0.0759
Leishmania major cysteine peptidase A (CPA) 0.0015 0.0021 0.0057
Entamoeba histolytica DNA topoisomerase II, putative 0.0069 0.0351 0.3207
Onchocerca volvulus 0.0046 0.0214 0.0209
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0042 0.019 0.0983
Trypanosoma brucei polo-like protein kinase 0.0188 0.1085 0.4036
Loa Loa (eye worm) paired box protein 0.0025 0.0085 0.0105
Schistosoma mansoni lamin 0.0024 0.0077 0.0137
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.013 0.0132
Trichomonas vaginalis glutaminase, putative 0.0217 0.1261 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0027 0.0083
Brugia malayi Latrophilin receptor protein 2 0.01 0.0543 0.0669
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0069 0.0351 0.0346
Loa Loa (eye worm) hypothetical protein 0.0032 0.0124 0.0153
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0162
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0153 0.0869 0.4533
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0012 0.0005 0.001
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0069 0.0353 0.0348
Schistosoma mansoni intermediate filament proteins 0.0024 0.0077 0.0137
Echinococcus granulosus acetylcholinesterase 0.0275 0.162 0.3098
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0267 0.1572 0.3007
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0027 0.0177
Loa Loa (eye worm) fibroinase 0.0015 0.0021 0.0025
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.0018 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.0279 0.1025
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0069 0.0351 0.0358
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0015 0.0021 0.0021
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.1085 0.8596
Mycobacterium ulcerans aldehyde dehydrogenase 0.0054 0.0262 0.1369
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0652 0.7564
Trypanosoma cruzi endonuclease G, putative 0.002 0.005 0.0166
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.013 0.0132
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0065 0.033 0.0622
Plasmodium vivax glutathione reductase, putative 0.0046 0.0214 0.0781
Loa Loa (eye worm) hypothetical protein 0.0046 0.0214 0.0264
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0125 0.0698 0.2591
Entamoeba histolytica hypothetical protein 0.0062 0.0312 0.2847
Echinococcus multilocularis isocitrate dehydrogenase 0.0065 0.033 0.0336
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.1085 0.8596
Loa Loa (eye worm) ctsf protein 0.0015 0.0021 0.0025
Brugia malayi 'Paired box' domain containing protein 0.0025 0.0085 0.0104
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0296 0.0301
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.013 0.0249
Leishmania major hypothetical protein, conserved 0.0052 0.0251 0.0921
Chlamydia trachomatis DNA gyrase subunit A 0.0318 0.1884 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0077 0.0402 0.0495
Echinococcus granulosus paired box protein pax 1 0.0025 0.0085 0.0163
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0077 0.0402 0.0494
Schistosoma mansoni aldehyde dehydrogenase 0.0054 0.0262 0.0492
Onchocerca volvulus 0.0025 0.0085 0.008
Loa Loa (eye worm) hypothetical protein 0.0042 0.019 0.0234
Trichomonas vaginalis DNA topoisomerase II, putative 0.0069 0.0351 0.2757
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0021 0.0122
Loa Loa (eye worm) hypothetical protein 0.0125 0.0698 0.0861
Echinococcus granulosus acetylcholinesterase 0.0275 0.162 0.3098
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.1085 0.8596
Plasmodium vivax acyl-CoA synthetase, putative 0.0032 0.0124 0.0443
Echinococcus multilocularis cysteine protease 0.0015 0.0021 0.0021
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0267 0.1572 0.1601
Trypanosoma cruzi endonuclease G, putative 0.002 0.005 0.0166
Schistosoma mansoni paired box protein pax-1-related 0.0025 0.0085 0.0153
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0026 0.0089 0.0775
Loa Loa (eye worm) hypothetical protein 0.0046 0.0214 0.0264
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0021 0.0122
Wolbachia endosymbiont of Brugia malayi cytochrome c2 0.0099 0.0537 0.2743
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0046 0.0214 0.0218
Brugia malayi MH2 domain containing protein 0.0033 0.0129 0.0157
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0033 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0086 0.0106
Onchocerca volvulus 0.0613 0.3699 0.3696
Echinococcus multilocularis musashi 0.0024 0.0077 0.0078
Brugia malayi hypothetical protein 0.0062 0.0312 0.0384
Loa Loa (eye worm) vab-3 0.0025 0.0085 0.0105
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.019 0.0983
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0071 0.0522
Brugia malayi glutaminase DH11.1 0.0217 0.1261 0.1554
Trypanosoma cruzi cysteine peptidase, putative 0.0057 0.0279 0.1025
Loa Loa (eye worm) hypothetical protein 0.0052 0.0251 0.031
Schistosoma mansoni peptidase Clp (S14 family) 0.0125 0.0698 0.1327
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.058 0.6714
Echinococcus multilocularis peptidase Clp (S14 family) 0.0082 0.0433 0.0441
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0027 0.0083
Brugia malayi paired box protein 0.0025 0.0085 0.0104
Brugia malayi paired box pox-meso protein 0.0025 0.0085 0.0104
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0012 0.0005 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.0083
Mycobacterium ulcerans glutaminase 0.0217 0.1261 0.6682
Schistosoma mansoni hypothetical protein 0.01 0.0543 0.103
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.0083
Schistosoma mansoni transcription factor LCR-F1 0.0062 0.0312 0.0588
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0447 0.2679 1
Brugia malayi 'Paired box' domain containing protein 0.0025 0.0085 0.0104
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0065 0.033 0.0336
Brugia malayi AMP-binding enzyme family protein 0.0012 0.0005 0.0005
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0032 0.0124 0.0519
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0033 0.013 0.0239
Brugia malayi chromobox protein homolog 3 0.0033 0.0129 0.0158
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0125 0.0698 0.3687
Loa Loa (eye worm) glutaminase 0.0217 0.1261 0.1555
Onchocerca volvulus 0.0046 0.0214 0.0209
Echinococcus granulosus zinc finger protein 0.002 0.0049 0.0093
Brugia malayi Troponin T 0.0069 0.0353 0.0435
Schistosoma mansoni hypothetical protein 0.0021 0.0055 0.0096
Schistosoma mansoni zinc finger protein 0.002 0.0049 0.0084
Loa Loa (eye worm) hypothetical protein 0.0046 0.0214 0.0264
Echinococcus granulosus oncosphere protein Tso22e 0.0144 0.0817 0.1563
Leishmania major hypothetical protein, conserved 0.0015 0.0023 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0021 0.0122
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0023 0.0072 0.0356
Onchocerca volvulus 0.0015 0.0021 0.0015
Brugia malayi intermediate filament protein 0.0024 0.0077 0.0093
Plasmodium vivax cytochrome c, putative 0.0099 0.0537 0.1988
Onchocerca volvulus Serine\/threonine kinase homolog 0.0188 0.1085 0.108
Schistosoma mansoni serine/threonine protein kinase 0.0188 0.1085 0.2066
Loa Loa (eye worm) troponin 0.0069 0.0353 0.0436
Loa Loa (eye worm) transcription factor SMAD2 0.0478 0.2867 0.3536
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0077 0.0402 0.0409
Loa Loa (eye worm) Smad1 0.0033 0.0129 0.0159
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0065 0.033 0.1215
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0012 0.0005 0.0006
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.058 0.3057
Leishmania major cathepsin L-like protease 0.0015 0.0021 0.0057
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0251 0.0921
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0027 0.0083
Trypanosoma cruzi polo-like protein kinase, putative 0.0188 0.1085 0.4036
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0015 0.0021 0.0025
Loa Loa (eye worm) hypothetical protein 0.0042 0.019 0.0234
Brugia malayi Cathepsin L-like precursor 0.0015 0.0021 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0129 0.0989
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0021 0.0122
Schistosoma mansoni paired box protein pax-6 0.0025 0.0085 0.0153
Loa Loa (eye worm) troponin I 0.0116 0.0645 0.0795
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0251 0.0921
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0021 0.0122
Entamoeba histolytica hypothetical protein 0.0062 0.0312 0.2847
Brugia malayi Isocitrate dehydrogenase 0.0065 0.033 0.0406
Brugia malayi N-terminal motif family protein 0.0188 0.1083 0.1334
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0015 0.0021 0.0122
Loa Loa (eye worm) hypothetical protein 0.0046 0.0214 0.0264
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0069 0.0351 0.0432
Trichomonas vaginalis CAMK family protein kinase 0.0188 0.1085 0.8596
Loa Loa (eye worm) hypothetical protein 0.0613 0.3699 0.4561
Chlamydia trachomatis DNA gyrase subunit B 0.0153 0.0869 0.4533
Plasmodium falciparum cysteine proteinase falcipain 3 0.0015 0.0021 0.0057
Echinococcus granulosus paired box protein pax 6 0.0025 0.0085 0.0163
Brugia malayi Carboxylesterase family protein 0.0275 0.162 0.1996
Brugia malayi Probable DNA topoisomerase II 0.0069 0.0351 0.0432
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0026 0.0089 0.0666
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0125 0.0698 0.3612
Brugia malayi serine/threonine-protein kinase plk-2 0.0188 0.1085 0.1336
Loa Loa (eye worm) carboxylesterase 0.0275 0.162 0.1997
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0033 0.013 0.0249
Schistosoma mansoni glutaminase 0.0217 0.1261 0.2404
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0144 0.0817 0.0813
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0058 0.0284 0.1043
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.0501 0.3946
Echinococcus multilocularis paired box protein pax 6 0.0025 0.0085 0.0087
Echinococcus multilocularis geminin 0.0861 0.5229 0.5324
Echinococcus granulosus Smad4 0.0033 0.0129 0.0246
Onchocerca volvulus 0.0033 0.013 0.0125
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0318 0.1884 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0054 0.0262 0.1369
Loa Loa (eye worm) hypothetical protein 0.0069 0.0353 0.0436
Schistosoma mansoni paired box protein pax-6 0.0025 0.0085 0.0153
Brugia malayi MH2 domain containing protein 0.0478 0.2867 0.3535
Schistosoma mansoni hypothetical protein 0.0116 0.0645 0.1225
Brugia malayi latrophilin 2 splice variant baaae 0.0216 0.1257 0.1549
Entamoeba histolytica acyl-CoA synthetase, putative 0.0042 0.019 0.1711
Echinococcus granulosus paired box protein pax 6 0.0025 0.0085 0.0163
Schistosoma mansoni cytochrome c 0.0099 0.0537 0.1018

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1 ug ml-1 Inhibitory activity against E. coli DNA gyrase ChEMBL. 15125947
IC50 (binding) = 1 ug ml-1 Inhibitory activity against E. coli DNA gyrase ChEMBL. 15125947
MIC (functional) = 8 ug ml-1 Inhibitory activity against Staphylococcus aureus FDA 209P ChEMBL. 15125947
MIC (functional) = 8 ug ml-1 Inhibitory activity against Staphylococcus aureus KMP9 ChEMBL. 15125947
MIC (functional) = 16 ug ml-1 Inhibitory activity against Staphylococcus aureus FDA 209P ChEMBL. 15125947
MIC (functional) = 16 ug ml-1 Inhibitory activity against Staphylococcus aureus KMP9 ChEMBL. 15125947
MIC (functional) = 32 ug ml-1 Inhibitory activity against Enterococcus faecalis KU 1777 ChEMBL. 15125947
MIC (functional) = 32 ug ml-1 Inhibitory activity against Enterococcus faecalis ATCC 29212 ChEMBL. 15125947
MIC (functional) = 64 ug ml-1 Inhibitory activity against Enterococcus faecalis ATCC 29212 ChEMBL. 15125947

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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