Detailed information for compound 1589846

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 441.479 | Formula: C26H23N3O4
  • H donors: 4 H acceptors: 4 LogP: 4.99 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(NC(=O)c1ccccc1NC(=O)c1cc2c([nH]1)cccc2)CCc1ccccc1
  • InChi: 1S/C26H23N3O4/c30-24(29-22(26(32)33)15-14-17-8-2-1-3-9-17)19-11-5-7-13-21(19)28-25(31)23-16-18-10-4-6-12-20(18)27-23/h1-13,16,22,27H,14-15H2,(H,28,31)(H,29,30)(H,32,33)
  • InChiKey: XLWHWNHGNRPPBH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cholecystokinin A receptor Starlite/ChEMBL References
Homo sapiens cholecystokinin B receptor Starlite/ChEMBL References
Rattus norvegicus Cholecystokinin A receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132882 All targets in OG5_132882
Brugia malayi sulfakinin receptor protein Get druggable targets OG5_132882 All targets in OG5_132882
Brugia malayi hypothetical protein Get druggable targets OG5_132882 All targets in OG5_132882
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum FMRFamide receptor, putative Cholecystokinin A receptor   444 aa 363 aa 21.2 %
Echinococcus multilocularis neuropeptides capa receptor Cholecystokinin A receptor   444 aa 400 aa 21.0 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Cholecystokinin A receptor   444 aa 374 aa 24.6 %
Schistosoma mansoni rhodopsin-like orphan GPCR Cholecystokinin A receptor   444 aa 380 aa 24.2 %
Echinococcus multilocularis g protein coupled receptor Cholecystokinin A receptor   444 aa 396 aa 23.2 %
Onchocerca volvulus Cholecystokinin A receptor   444 aa 385 aa 28.6 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Cholecystokinin A receptor   444 aa 364 aa 28.6 %
Echinococcus granulosus g protein coupled receptor Cholecystokinin A receptor   444 aa 399 aa 23.3 %
Echinococcus granulosus rhodopsin orphan GPCR cholecystokinin A receptor 428 aa 373 aa 19.6 %
Echinococcus granulosus orexin receptor type 2 Cholecystokinin A receptor   444 aa 366 aa 23.5 %
Echinococcus multilocularis serotonin receptor Cholecystokinin A receptor   444 aa 468 aa 22.4 %
Schistosoma mansoni biogenic amine (5HT) receptor Cholecystokinin A receptor   444 aa 362 aa 28.2 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Cholecystokinin A receptor   444 aa 383 aa 21.7 %
Echinococcus granulosus rhodopsin orphan GPCR Cholecystokinin A receptor   444 aa 363 aa 19.6 %
Echinococcus granulosus g protein coupled receptor Cholecystokinin A receptor   444 aa 396 aa 23.5 %
Echinococcus multilocularis orexin receptor type 2 Cholecystokinin A receptor   444 aa 362 aa 22.4 %
Schistosoma mansoni amine GPCR Cholecystokinin A receptor   444 aa 412 aa 26.2 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Cholecystokinin A receptor   444 aa 379 aa 24.8 %
Echinococcus multilocularis g protein coupled receptor Cholecystokinin A receptor   444 aa 403 aa 24.1 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Cholecystokinin A receptor   444 aa 395 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear hormone receptor 0.003 0.0094 0.0262
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0028 0.0072
Schistosoma mansoni hypothetical protein 0.0346 0.2292 0.2292
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0094 0.0262
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0229 0.0645
Mycobacterium tuberculosis Diacylglycerol kinase 0.0057 0.0279 0.0221
Loa Loa (eye worm) hypothetical protein 0.003 0.0094 0.0066
Loa Loa (eye worm) oxidoreductase 0.0102 0.0594 0.0567
Trypanosoma brucei heat shock protein, putative 0.0031 0.0104 0.0402
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0067 0.0274
Schistosoma mansoni importin beta-1 0.0028 0.008 0.008
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0629 0.0603
Brugia malayi jmjC domain containing protein 0.006 0.0305 0.086
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0629 0.0603
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.011 0.1959
Echinococcus multilocularis neuropeptide s receptor 0.0909 0.6216 0.6206
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0065 0.0262
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0222 0.0624
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0064 0.0004
Echinococcus granulosus aldo keto reductase 0.0102 0.0594 0.0567
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0067 0.0274
Schistosoma mansoni smad 0.0024 0.0056 0.0056
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0078 0.0216
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.011 0.005
Onchocerca volvulus 0.0102 0.0594 0.8318
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0222 0.0163
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0226 0.0198
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0094 0.0066
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0094 0.0094
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0222 0.0163
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0443 0.0416
Echinococcus granulosus smad 0.0024 0.0056 0.0027
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0102 0.0594 0.1676
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.011 0.0429
Schistosoma mansoni heat shock protein 0.0031 0.0104 0.0104
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.0104 0.1346
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0198 0.0556
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0094 0.0066
Schistosoma mansoni intermediate filament proteins 0.0028 0.0078 0.0078
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0222 0.0624
Echinococcus multilocularis voltage gated potassium channel subunit 0.0029 0.009 0.0062
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0111 0.066 0.0634
Brugia malayi CHE-14 protein 0.0043 0.0187 0.0524
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.011 0.0498
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0187 0.0159
Loa Loa (eye worm) hypothetical protein 0.0036 0.0137 0.0109
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0029 0.009 0.0444
Brugia malayi 6-phosphofructokinase 0.0107 0.0629 0.1776
Brugia malayi MH2 domain containing protein 0.0024 0.0056 0.0154
Schistosoma mansoni smad1 5 8 and 0.0024 0.0056 0.0056
Echinococcus multilocularis geminin 0.0346 0.2292 0.227
Schistosoma mansoni hypothetical protein 0.0111 0.066 0.066
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.1228 0.1203
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0094 0.0262
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0251 0.0223
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0067 0.0274
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0443 1
Toxoplasma gondii diacylglycerol kinase, putative 0.0057 0.0279 0.1795
Loa Loa (eye worm) oxidoreductase 0.0102 0.0594 0.0567
Loa Loa (eye worm) glutaminase 2 0.0265 0.1729 0.1706
Trichomonas vaginalis glutaminase, putative 0.0265 0.1729 1
Echinococcus granulosus cpg binding protein 0.0121 0.0731 0.0705
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0029 0.009 0.0328
Entamoeba histolytica hypothetical protein 0.0037 0.014 0.0111
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.008 0.0271
Loa Loa (eye worm) hypothetical protein 0.0048 0.0222 0.0194
Echinococcus multilocularis aldehyde reductase 0.0072 0.0388 0.0361
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0094 0.0066
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0067 0.0274
Trichomonas vaginalis heat shock protein, putative 0.0025 0.006 0.0235
Giardia lamblia Aldose reductase 0.0102 0.0594 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0086 0.0389
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0086 0.0389
Leishmania major hypothetical protein, conserved 0.0057 0.0279 0.1324
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0226 0.0198
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.011 0.0429
Trichomonas vaginalis aldo-keto reductase, putative 0.0029 0.009 0.0414
Echinococcus multilocularis heat shock protein 0.0031 0.0104 0.0076
Trichomonas vaginalis bmru protein, putative 0.0057 0.0279 0.1518
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0057 0.0279 0.1387
Echinococcus granulosus aldehyde reductase 0.0072 0.0388 0.0361
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0086 0.0414
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0177 0.092
Onchocerca volvulus 0.0102 0.0594 0.8318
Schistosoma mansoni lamin 0.0028 0.0078 0.0078
Trypanosoma brucei prostaglandin f synthase 0.0102 0.0594 0.2985
Trypanosoma brucei Heat shock protein 83, putative 0.0031 0.0104 0.0402
Loa Loa (eye worm) Smad1 0.0024 0.0056 0.0027
Brugia malayi mbt repeat family protein 0.0049 0.0226 0.0636
Schistosoma mansoni nuclear hormone receptor 0.003 0.0094 0.0094
Schistosoma mansoni diacylglycerol kinase theta 0.0057 0.0279 0.0279
Brugia malayi Probable ClpP-like protease 0.008 0.0443 0.125
Entamoeba histolytica aldose reductase, putative 0.0102 0.0594 0.0567
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0086 0.0389
Trypanosoma cruzi diacylglycerol kinase, putative 0.0057 0.0279 0.1387
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0084 0.0056
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.011 0.0429
Schistosoma mansoni sphingoid long chain base kinase 0.1452 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0067 0.0274
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0594 0.0567
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.011 0.0081
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Brugia malayi NADH-dependent xylose reductase 0.0029 0.009 0.0252
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0153 0.2198
Trypanosoma brucei hypothetical protein, conserved 0.0057 0.0279 0.1324
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.014 0.014
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0086 0.0389
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0078 0.0049
Echinococcus multilocularis importin subunit beta 1 0.0028 0.008 0.0051
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0104 0.0471
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0028 0.0072
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0222 0.0163
Echinococcus granulosus Diacylglycerol kinase theta 0.0057 0.0279 0.0252
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0629 0.3565
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Loa Loa (eye worm) transcription factor SMAD2 0.0359 0.2386 0.2365
Echinococcus granulosus heat shock protein 0.0031 0.0104 0.0076
Entamoeba histolytica hypothetical protein 0.0037 0.014 0.0111
Loa Loa (eye worm) hypothetical protein 0.0036 0.0137 0.0109
Entamoeba histolytica hypothetical protein, conserved 0.1452 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0094 0.0262
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0594 0.0567
Echinococcus multilocularis aldo keto reductase 0.0102 0.0594 0.0567
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0094 0.0066
Mycobacterium ulcerans hypothetical protein 0.0154 0.0958 0.0904
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0057 0.0279 0.0279
Brugia malayi MH2 domain containing protein 0.0359 0.2386 0.6747
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0594 0.0567
Mycobacterium ulcerans oxidoreductase 0.0102 0.0594 0.0537
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0629 0.0573
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0094 0.1191
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0094 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0094 0.0066
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0123 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0094 0.0262
Trichomonas vaginalis diacylglycerol kinase, putative 0.0057 0.0279 0.1518
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0443 0.0416
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0226 0.0198
Leishmania major sphingosine kinase A, B, putative 0.0057 0.0279 0.1324
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0123 0.0064
Trichomonas vaginalis helicase, putative 0.0026 0.0067 0.0274
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0305 0.0278
Brugia malayi nuclear receptor NHR-88 0.003 0.0094 0.0262
Entamoeba histolytica diacylglycerol kinase, putative 0.0057 0.0279 0.0252
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.0588 0.0561
Mycobacterium ulcerans hypothetical protein 0.1452 1 1
Schistosoma mansoni lamin 0.0028 0.0078 0.0078
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0629 0.3565
Trypanosoma brucei Sphingosine kinase 0.0057 0.0279 0.1324
Toxoplasma gondii hypothetical protein 0.0047 0.0214 0.1327
Brugia malayi MH2 domain containing protein 0.0024 0.0056 0.0154
Loa Loa (eye worm) hypothetical protein 0.0028 0.0078 0.0049
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0029 0.009 0.0062
Brugia malayi heat shock protein 90 0.0031 0.0104 0.0292
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0222 0.0163
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0036 0.0133 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0094 0.0262
Echinococcus multilocularis microtubule associated protein 2 0.0668 0.454 0.4525
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0077 0.0309
Schistosoma mansoni hypothetical protein 0.0297 0.1957 0.1957
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0067 0.0274
Schistosoma mansoni ran 0.0021 0.0028 0.0028
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0043 0.0136
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0077 0.1363
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.014 0.0111
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0094 0.0066
Trypanosoma cruzi diacylglycerol kinase, putative 0.0057 0.0279 0.1387
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0029 0.009 0.1496
Mycobacterium ulcerans diacylglycerol kinase 0.0057 0.0279 0.0221
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0305 0.0278
Loa Loa (eye worm) hypothetical protein 0.0049 0.0226 0.0198
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0094 0.0262
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0067 0.0274
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0094 0.0066
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.1962 0.1939
Mycobacterium ulcerans glutaminase 0.0265 0.1729 0.1679
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.0598 0.0598
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.1572 0.1548
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0065 0.0264
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0065 0.0194
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0629 0.0603
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0226 0.0226
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0086 0.1571
Onchocerca volvulus Huntingtin homolog 0.0119 0.0712 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0094 0.0066
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0172 0.0823
Trypanosoma brucei heat shock protein, putative 0.0031 0.0104 0.0402
Loa Loa (eye worm) hypothetical protein 0.0056 0.0273 0.0246
Echinococcus multilocularis Diacylglycerol kinase theta 0.0057 0.0279 0.0252
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0273 0.0246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0094 0.0066
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.011 0.011
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0187 0.0159
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0443 0.6732
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0222 0.1022
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0222 0.1022
Schistosoma mansoni ferritin light chain 0.0026 0.0064 0.0064
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0043 0.0136
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Trypanosoma brucei heat shock protein, putative 0.0031 0.0104 0.0402
Echinococcus multilocularis neuropeptide receptor A26 0.0909 0.6216 0.6206
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0057 0.0279 0.0252
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.011 0.0081
Loa Loa (eye worm) heat shock protein 90 0.0031 0.0104 0.0076
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0086 0.0389
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0094 0.0066
Echinococcus multilocularis lamin dm0 0.0028 0.0078 0.0049
Brugia malayi Calcitonin receptor-like protein seb-1 0.0352 0.2335 0.6601
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0137 0.1418
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0094 0.0094
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0057 0.0279 0.0252
Leishmania major hypothetical protein, conserved 0.0057 0.0279 0.1324
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0594 0.0567
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0064 0.0004
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0028 0.0205
Mycobacterium leprae Possible oxidoreductase 0.0029 0.009 0.0538
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0443 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0102 0.0594 0.1676
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0222 0.2848
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0086 0.0414
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0057 0.0279 0.1387
Schistosoma mansoni hypothetical protein 0.0042 0.0176 0.0176
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0043 0.0148
Trichomonas vaginalis heat shock protein, putative 0.0025 0.006 0.0235
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.011 0.0498
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0094 0.0094
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0443 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0254 0.0227
Brugia malayi Endoplasmin precursor 0.0031 0.0104 0.0292
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0086 0.0464
Onchocerca volvulus 0.0028 0.0078 0.0957
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.006 0.0166
Schistosoma mansoni hypothetical protein 0.0042 0.0176 0.0176
Trypanosoma brucei heat shock protein, putative 0.0031 0.0104 0.0402
Brugia malayi diacylglycerol kinase 0.0057 0.0279 0.0786
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0056 0.0027
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0172 0.0823
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0094 0.0262
Schistosoma mansoni survival motor neuron protein 0.0049 0.0229 0.0229
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0222 0.0194
Schistosoma mansoni hypothetical protein 0.1218 0.8366 0.8366
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0104 0.0496
Brugia malayi Eye-specific diacylglycerol kinase 0.0057 0.0279 0.0786
Trichomonas vaginalis aldo/keto reductase, putative 0.0102 0.0594 0.3358
Echinococcus granulosus Diacylglycerol kinase zeta 0.0057 0.0279 0.0252
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.1572 0.1548
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0028 0.0077
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0046
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0594 0.0567
Brugia malayi Isocitrate dehydrogenase 0.0032 0.011 0.0306
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0067 0.0274
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.0877 0.2478
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0084 0.0056
Echinococcus granulosus neuropeptide s receptor 0.0909 0.6216 0.6206
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0629 0.0603
Mycobacterium tuberculosis Conserved protein 0.0029 0.009 0.0031
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Entamoeba histolytica hypothetical protein 0.0037 0.014 0.0111
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0065 0.1071
Onchocerca volvulus 0.0049 0.0226 0.3074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0198 0.017
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0443 0.2968
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0057 0.0279 0.1795
Plasmodium falciparum heat shock protein 90 0.0031 0.0104 0.2002
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0629 0.0603
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0104 0.0076
Brugia malayi Diacylglycerol kinase protein 2 0.0057 0.0279 0.0786
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0849 0.0823
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0629 0.0573
Entamoeba histolytica alcohol dehydrogenase, putative 0.0029 0.009 0.0062
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0279 0.1387
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.006 0.0237
Schistosoma mansoni cpg binding protein 0.0121 0.0731 0.0731
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0057 0.0279 0.1795
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0065 0.1071
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0234 0.1152
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0187 0.0159
Loa Loa (eye worm) hypothetical protein 0.0048 0.0222 0.0194
Trypanosoma cruzi Sphingosine kinase 0.0057 0.0279 0.1387
Echinococcus granulosus microtubule associated protein 2 0.0668 0.454 0.4525
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0104 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0067 0.0274
Brugia malayi RNA, U transporter 1 0.0079 0.0438 0.1236
Mycobacterium ulcerans hypothetical protein 0.0048 0.0222 0.0163
Toxoplasma gondii aldo-keto reductase 0.0029 0.009 0.0444
Onchocerca volvulus 0.0102 0.0594 0.8318
Trypanosoma cruzi Heat shock protein 83, putative 0.0031 0.0104 0.0471
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0153 0.0125
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0094 0.0262
Brugia malayi phosphofructokinase 0.0107 0.0629 0.1776
Echinococcus granulosus ferritin 0.0026 0.0064 0.0035
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Loa Loa (eye worm) hypothetical protein 0.0028 0.008 0.0051
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0251 0.0192
Toxoplasma gondii heat shock protein 90, putative 0.0031 0.0104 0.0545
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0056 0.0056
Entamoeba histolytica aldose reductase, putative 0.0102 0.0594 0.0567
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0352 0.2335 0.2313
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0629 1
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.1923 1
Schistosoma mansoni cpg binding protein 0.0121 0.0731 0.0731
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0067 0.0274
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.006 0.0032
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0198 0.0198
Brugia malayi sulfakinin receptor protein 0.0524 0.3536 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.0588 0.0561
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0137 0.0077
Loa Loa (eye worm) hypothetical protein 0.0057 0.0279 0.0252
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0064 0.0103
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0594 0.0567
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Echinococcus multilocularis protein dispatched 1 0.0049 0.0229 0.0201
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0057 0.0279 0.0279
Schistosoma mansoni jumonji domain containing protein 0.006 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0101 0.0588 0.0561
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0831 0.5671 0.5658
Schistosoma mansoni hypothetical protein 0.0111 0.066 0.066
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0067 0.0274
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0629 0.3172
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0629 0.0603
Mycobacterium leprae Conserved hypothetical protein 0.0072 0.0388 0.5772
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0102 0.0594 0.9376
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0056 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0094 0.0262
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0094 0.1191
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0094 0.0094
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0443 0.2968
Loa Loa (eye worm) hypothetical protein 0.0102 0.0594 0.0567
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.1923 1
Schistosoma mansoni hypothetical protein 0.0049 0.0229 0.0229
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0198 0.017
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.1923 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0198 0.017
Echinococcus multilocularis GPCR, family 2 0.0111 0.066 0.0634
Echinococcus granulosus FTZ F1 alpha 0.003 0.0094 0.0066
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0251 0.0192
Loa Loa (eye worm) hypothetical protein 0.0043 0.0187 0.0159
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0849 0.4335
Toxoplasma gondii hypothetical protein 0.0028 0.0077 0.0351
Schistosoma mansoni heat shock protein 0.0031 0.0104 0.0104
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0305 0.0278
Loa Loa (eye worm) diacylglycerol kinase 2 0.0057 0.0279 0.0252
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0065 0.0264
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0104 0.0471
Brugia malayi hypothetical protein 0.0057 0.0279 0.0786
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0443 0.0443
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0067 0.0274
Brugia malayi jmjC domain containing protein 0.0067 0.0351 0.0989
Schistosoma mansoni hypothetical protein 0.0037 0.014 0.014
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0094 0.0094
Leishmania major importin beta-1 subunit, putative 0.0023 0.0043 0.0077
Echinococcus granulosus Niemann Pick C1 protein 0.0144 0.0889 0.0863
Brugia malayi latrophilin 2 splice variant baaae 0.024 0.156 0.4408
Brugia malayi CXXC zinc finger family protein 0.0115 0.0686 0.1936
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0094 0.0066
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0222 0.0163
Schistosoma mansoni sphingosine kinase A B 0.1452 1 1
Brugia malayi hypothetical protein 0.0119 0.0712 0.201
Loa Loa (eye worm) hypothetical protein 0.003 0.0094 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0187 0.0977
Entamoeba histolytica diacylglycerol kinase, putative 0.0057 0.0279 0.0252
Trypanosoma cruzi Sphingosine kinase 0.0057 0.0279 0.1387
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0594 0.0567
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0594 0.0567
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0094 0.0066
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0056 0.0027
Schistosoma mansoni hypothetical protein 0.0346 0.2292 0.2292
Echinococcus granulosus ceramide kinase 0.0057 0.0279 0.0252
Leishmania major prostaglandin f synthase, putative 0.0102 0.0594 0.2985
Giardia lamblia Grp94/Hsp90 0.0025 0.006 0.0556
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0086 0.0389
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Loa Loa (eye worm) hypothetical protein 0.0352 0.2335 0.2313
Giardia lamblia Aldose reductase 0.0102 0.0594 1
Trypanosoma brucei heat shock protein, putative 0.0031 0.0104 0.0402
Mycobacterium tuberculosis Probable oxidoreductase 0.0102 0.0594 0.0537
Loa Loa (eye worm) endoplasmin 0.0031 0.0104 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0198 0.0198
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.0588 0.0561
Loa Loa (eye worm) MBCTL1 0.0056 0.0273 0.0246
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0104 0.0402
Brugia malayi diacylglycerol kinase 0.0057 0.0279 0.0786
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Entamoeba histolytica diacylglycerol kinase, putative 0.0057 0.0279 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.009 0.0414
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0104 0.0471
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.0849 0.4335
Trichomonas vaginalis ferritin, putative 0.0026 0.0064 0.0258
Schistosoma mansoni ferritin 0.0026 0.0064 0.0064
Schistosoma mansoni Smad4 0.0024 0.0056 0.0056
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0177 0.1063
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0172 0.0823
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0037
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0351 0.0351
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0629 0.0603
Schistosoma mansoni ferritin 0.0026 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0094 0.0262
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Echinococcus multilocularis cpg binding protein 0.0121 0.0731 0.0705
Onchocerca volvulus Ceramide kinase 1 homolog 0.0057 0.0279 0.3832
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0849 0.4375
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0273 0.0246
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0094 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0094 0.0262
Schistosoma mansoni hypothetical protein 0.0111 0.066 0.066
Echinococcus multilocularis dnaJ subfamily B 0.1218 0.8366 0.8362
Echinococcus multilocularis endoplasmin 0.0025 0.006 0.0032
Loa Loa (eye worm) hypothetical protein 0.003 0.0094 0.0066
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.011 0.0081
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0077 0.0309
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.011 0.2123
Echinococcus granulosus snurportin 1 0.0298 0.1962 0.1939
Echinococcus multilocularis snurportin 1 0.0298 0.1962 0.1939
Trypanosoma cruzi aldo/keto reductase, putative 0.0102 0.0594 0.3035
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0443 1
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0629 0.0603
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0443 1
Onchocerca volvulus 0.0102 0.0594 0.8318
Schistosoma mansoni diacylglycerol kinase theta 0.0057 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.003 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0119 0.0712 0.0685
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0029 0.009 0.0062
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0226 0.0198
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0233 0.0205
Schistosoma mansoni pol-related 0.0102 0.0594 0.0594
Echinococcus granulosus endoplasmin 0.0025 0.006 0.0032
Brugia malayi Latrophilin receptor protein 2 0.0111 0.066 0.1864
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0273 0.0246
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0064 0.0004
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0086 0.1394
Echinococcus granulosus aldo keto reductase 0.0102 0.0594 0.0567
Loa Loa (eye worm) MH2 domain-containing protein 0.0359 0.2386 0.2365
Brugia malayi Smad1 0.0024 0.0056 0.0154
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0273 0.0769
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0123 0.0064
Loa Loa (eye worm) oxidoreductase 0.0102 0.0594 0.0567
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0177 0.3582
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0222 0.0624
Loa Loa (eye worm) hypothetical protein 0.0111 0.066 0.0634
Onchocerca volvulus 0.0049 0.0229 0.3121
Mycobacterium ulcerans hypothetical protein 0.0029 0.009 0.0031
Trypanosoma cruzi aldo/keto reductase, putative 0.0029 0.009 0.0397
Echinococcus multilocularis protein patched 0.0043 0.0187 0.0159
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0629 0.0629
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0067 0.0274
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.011 0.0581
Loa Loa (eye worm) hypothetical protein 0.0057 0.0279 0.0252
Echinococcus granulosus mixed lineage leukemia protein mll 0.0029 0.0084 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0094 0.0066
Onchocerca volvulus 0.0029 0.009 0.114
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0094 0.0066
Trichomonas vaginalis bmru protein, putative 0.0057 0.0279 0.1518
Echinococcus multilocularis heat shock protein 90 0.0025 0.006 0.0032
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0094 0.0262
Schistosoma mansoni ferritin 0.0026 0.0064 0.0064
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0094 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0094 0.0262
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.011 0.0081
Echinococcus multilocularis heat shock protein 90 0.0031 0.0104 0.0076
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.008 0.0367
Toxoplasma gondii heat shock protein HSP90 0.0031 0.0104 0.0545
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0023 0.0043 0.0015
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.0958 0.0904
Plasmodium vivax endoplasmin, putative 0.0031 0.0104 0.1835
Plasmodium falciparum diacylglycerol kinase, putative 0.0057 0.0279 0.6128
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Schistosoma mansoni hypothetical protein 0.0298 0.1962 0.1962
Leishmania major diacylglycerol kinase-like protein 0.0057 0.0279 0.1324
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0094 0.0066
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0043 0.0136
Plasmodium vivax importin-beta 2, putative 0.0028 0.008 0.1238
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Toxoplasma gondii histone lysine methyltransferase SET1 0.0221 0.1426 1
Trypanosoma brucei diacylglycerol kinase, putative 0.0057 0.0279 0.1324
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.014 0.0111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0198 0.017
Loa Loa (eye worm) hypothetical protein 0.1452 1 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0222 0.2848
Brugia malayi MH1 domain containing protein 0.0024 0.0056 0.0154
Schistosoma mansoni smad1 5 8 and 0.0024 0.0056 0.0056
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0086 0.1394
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0057 0.0279 0.1518
Plasmodium falciparum aldehyde reductase, putative 0.0029 0.009 0.167
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0123 0.0064
Loa Loa (eye worm) ceramide kinase 0.0057 0.0279 0.0252
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0077 0.1183
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0244 0.1583 0.1583
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0222 0.1022
Echinococcus multilocularis aldo keto reductase 0.0102 0.0594 0.0567
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Schistosoma mansoni aldo-keto reductase 0.0102 0.0594 0.0594
Trichomonas vaginalis ran, putative 0.0021 0.0028 0.0051
Schistosoma mansoni coup transcription factor 0.003 0.0094 0.0094
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0102 0.0594 0.3358
Loa Loa (eye worm) hypothetical protein 0.0119 0.0712 0.0685
Brugia malayi glutaminase DH11.1 0.0265 0.1729 0.4888
Entamoeba histolytica diacylglycerol kinase, putative 0.0057 0.0279 0.0252
Loa Loa (eye worm) CXXC zinc finger family protein 0.0115 0.0686 0.0659
Schistosoma mansoni ran 0.0021 0.0028 0.0028
Trypanosoma cruzi aldo-keto reductase 0.0102 0.0594 0.3035
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0111 0.066 0.1864
Schistosoma mansoni cpg binding protein 0.0115 0.0686 0.0686
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Loa Loa (eye worm) hypothetical protein 0.008 0.0443 0.0416
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0067 0.0274
Echinococcus multilocularis ceramide kinase 0.0057 0.0279 0.0252
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0102 0.0594 0.2985
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0094 0.0094
Schistosoma mansoni apoferritin-2 0.0026 0.0064 0.0064
Plasmodium vivax diacylglycerol kinase, putative 0.0057 0.0279 0.6047
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0094 0.0094
Leishmania major aldo-keto reductase-like protein 0.0102 0.0594 0.2985
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0222 0.0194
Brugia malayi Importin beta-1 subunit 0.0028 0.008 0.0222
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0094 0.0066
Brugia malayi hypothetical protein 0.0524 0.3536 1
Onchocerca volvulus 0.0102 0.0594 0.8318
Leishmania major diacylglycerol kinase, putative 0.0057 0.0279 0.1324
Loa Loa (eye worm) hypothetical protein 0.0036 0.0137 0.0109
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.006 0.0237
Leishmania major hypothetical protein, conserved 0.0026 0.0065 0.0194
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Brugia malayi isocitrate dehydrogenase 0.0032 0.011 0.0306
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0029 0.009 0.0252
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0177 0.1063
Schistosoma mansoni ferritin 0.0026 0.0064 0.0064
Echinococcus granulosus hypothetical protein 0.0102 0.0594 0.0567
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0443 0.0386
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0094 0.0262
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0222 0.0163
Loa Loa (eye worm) hypothetical protein 0.024 0.156 0.1536
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0086 0.1023
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0056 0.0027
Loa Loa (eye worm) acetyltransferase 0.0142 0.0877 0.0851
Schistosoma mansoni endoplasmin 0.0031 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.003 0.0094 0.0066
Trypanosoma brucei heat shock protein, putative 0.0031 0.0104 0.0402
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0352 0.2335 0.6601
Schistosoma mansoni thyroid hormone receptor 0.003 0.0094 0.0094
Plasmodium falciparum importin beta, putative 0.0028 0.008 0.1417
Trichomonas vaginalis aldo-keto reductase, putative 0.0029 0.009 0.0414
Loa Loa (eye worm) hypothetical protein 0.0242 0.1572 0.1548
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0094 0.0066
Schistosoma mansoni aldo-keto reductase 0.0102 0.0594 0.0594
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0629 0.3565
Schistosoma mansoni hypothetical protein 0.024 0.156 0.156
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0102 0.0594 0.3358
Schistosoma mansoni endoplasmin 0.0031 0.0104 0.0104
Echinococcus multilocularis smad 0.0024 0.0056 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0198 0.0198
Echinococcus granulosus neuropeptide receptor A26 0.0909 0.6216 0.6206
Echinococcus granulosus aldo keto reductase 0.0102 0.0594 0.0567
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0094 0.0066
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0273 0.0246
Schistosoma mansoni hypothetical protein 0.0111 0.066 0.066
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0094 0.0066
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0064 0.0069
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0273 0.0273
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0137 0.2615
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0065 0.0884
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Loa Loa (eye worm) oxidoreductase 0.0102 0.0594 0.0567
Onchocerca volvulus 0.0048 0.0222 0.3016
Loa Loa (eye worm) hypothetical protein 0.0524 0.3536 0.3518
Schistosoma mansoni thyroid hormone receptor 0.003 0.0094 0.0094
Entamoeba histolytica alcohol dehydrogenase, putative 0.0029 0.009 0.0062
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0443 0.0386
Trypanosoma brucei heat shock protein, putative 0.0031 0.0104 0.0402
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0067 0.0274
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0086 0.1571
Echinococcus granulosus dnaJ subfamily B 0.1218 0.8366 0.8362
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0251 0.3356
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0094 0.0066
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0057 0.0279 0.1387
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0594 0.0567
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0067 0.0274
Toxoplasma gondii aldose reductase, putative 0.0102 0.0594 0.4045
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0629 0.3221
Loa Loa (eye worm) hypothetical protein 0.0048 0.0222 0.0194
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0102 0.0594 0.1676
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0222 0.0163
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0023 0.0043 0.0015
Schistosoma mansoni hypothetical protein 0.0042 0.0176 0.0176
Brugia malayi mbt repeat family protein 0.0049 0.0226 0.0636
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0036 0.0133 0.0105
Brugia malayi steroid hormone receptor 0.003 0.0094 0.0262
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0111 0.066 0.0634
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.013 0.0363
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0443 0.6732
Schistosoma mansoni microtubule-associated protein tau 0.0668 0.454 0.454
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0086 0.0414
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0137 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0067 0.0274
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Echinococcus granulosus expressed conserved protein 0.0095 0.0545 0.0518
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0629 0.3172
Brugia malayi MH1 domain containing protein 0.0024 0.0056 0.0154
Schistosoma mansoni patched 1 0.0043 0.0187 0.0187
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0226 0.0226
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0086 0.0389
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0094 0.0066
Plasmodium vivax diacylglycerol kinase, putative 0.0057 0.0279 0.6047
Echinococcus granulosus lamin dm0 0.0028 0.0078 0.0049
Echinococcus multilocularis aldo keto reductase 0.0102 0.0594 0.0567
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0102 0.0594 0.1676
Onchocerca volvulus 0.0115 0.0686 0.9629
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.006 0.0556
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0102 0.0594 0.2985
Plasmodium vivax aldehyde reductase, putative 0.0029 0.009 0.1496
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0102 0.0594 0.3358
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.0877 0.0877
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.011 0.0581
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0629 1
Plasmodium falciparum diacylglycerol kinase, putative 0.0057 0.0279 0.6128
Schistosoma mansoni smad1 5 8 and 0.0024 0.0056 0.0056
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0094 0.1191
Echinococcus multilocularis Niemann Pick C1 protein 0.0144 0.0889 0.0863
Plasmodium vivax heat shock protein 86, putative 0.0031 0.0104 0.1835
Onchocerca volvulus 0.0102 0.0594 0.8318
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0084 0.0084
Trichomonas vaginalis aldo/keto reductase, putative 0.0102 0.0594 0.3358
Echinococcus multilocularis sphingosine kinase 1 0.1452 1 1
Trichomonas vaginalis sphingosine kinase, putative 0.0057 0.0279 0.1518
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Trichomonas vaginalis aldo-keto reductase, putative 0.0029 0.009 0.0414
Schistosoma mansoni hypothetical protein 0.0057 0.0279 0.0279
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0094 0.0066
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0177 0.092
Trichomonas vaginalis sphingosine kinase, putative 0.0057 0.0279 0.1518
Brugia malayi Ceramide kinase 0.0057 0.0279 0.0786
Entamoeba histolytica hypothetical protein 0.0037 0.014 0.0111
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0226 0.3074
Schistosoma mansoni apoferritin-2 0.0026 0.0064 0.0064
Echinococcus granulosus lysine specific demethylase 5A 0.0067 0.0351 0.0324
Brugia malayi Cytochrome P450 family protein 0.005 0.0233 0.0656
Trichomonas vaginalis aldo/keto reductase, putative 0.0102 0.0594 0.3358
Loa Loa (eye worm) histone methyltransferase 0.0036 0.0133 0.0105
Trichomonas vaginalis diacylglycerol kinase, putative 0.0057 0.0279 0.1518
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0057 0.0279 0.1324
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0226 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0279 0.1518
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.0877 0.0851
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0198 0.017
Loa Loa (eye worm) hypothetical protein 0.003 0.0094 0.0066
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0094 0.0066
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.1923 1
Brugia malayi hypothetical protein 0.0037 0.014 0.0391
Echinococcus multilocularis expressed protein 0.0026 0.0064 0.0035
Echinococcus multilocularis expressed conserved protein 0.0095 0.0545 0.0518
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0057 0.0279 0.1518
Loa Loa (eye worm) latrophilin receptor protein 2 0.0111 0.066 0.0634
Plasmodium falciparum aldo-keto reductase, putative 0.0029 0.009 0.167
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.011 0.0081
Trypanosoma brucei heat shock protein, putative 0.0031 0.0104 0.0402
Loa Loa (eye worm) hypothetical protein 0.0036 0.0137 0.0109
Brugia malayi intermediate filament protein 0.0028 0.0078 0.0216
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0177 0.0149
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0222 0.0163
Echinococcus granulosus Smad4 0.0024 0.0056 0.0027
Loa Loa (eye worm) hypothetical protein 0.0036 0.0137 0.0109
Echinococcus multilocularis aldo keto reductase 0.0102 0.0594 0.0567
Trypanosoma brucei aldo/keto reductase, putative 0.0029 0.009 0.0328
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0078 0.0049
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0153 0.3139
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0086 0.0058
Loa Loa (eye worm) oxidoreductase 0.0102 0.0594 0.0567
Trichomonas vaginalis heat shock protein, putative 0.0025 0.006 0.0235
Entamoeba histolytica aldose reductase, putative 0.0102 0.0594 0.0567
Echinococcus multilocularis lamin 0.0028 0.0078 0.0049
Mycobacterium tuberculosis Conserved protein 0.1452 1 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.1228 0.1203
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0056 0.0027
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0137 0.2766
Schistosoma mansoni ferritin light chain 0.0026 0.0064 0.0064
Onchocerca volvulus 0.003 0.0094 0.1191
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.011 0.0081
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0029 0.009 0.0414
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.008 0.0271
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0029 0.0084 0.0056
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0056 0.0027
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0172 0.0757
Onchocerca volvulus 0.0057 0.0279 0.3832
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0222 0.0194
Echinococcus granulosus GPCR family 2 0.0111 0.066 0.0634
Echinococcus multilocularis musashi 0.0028 0.0078 0.0049
Loa Loa (eye worm) hypothetical protein 0.003 0.0094 0.0066
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0226 0.0226
Echinococcus granulosus expressed protein 0.0026 0.0064 0.0035
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0629 0.0629
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.011 0.0081
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0057 0.0279 0.0252
Trypanosoma brucei aldo-keto reductase, putative 0.0102 0.0594 0.2985
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0351 0.0351
Echinococcus granulosus heat shock protein 90 0.0031 0.0104 0.0076
Echinococcus granulosus lamin 0.0028 0.0078 0.0049
Echinococcus granulosus geminin 0.0346 0.2292 0.227
Schistosoma mansoni glutaminase 0.0265 0.1729 0.1729
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0064 0.0004
Loa Loa (eye worm) glutaminase 0.0265 0.1729 0.1706
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.0588 0.1659
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0629 0.3565
Loa Loa (eye worm) hypothetical protein 0.003 0.0094 0.0066
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0057 0.0279 0.1518
Brugia malayi 6-phosphofructokinase 0.0107 0.0629 0.1776
Entamoeba histolytica hypothetical protein 0.0023 0.0043 0.0015
Echinococcus granulosus importin subunit beta 1 0.0028 0.008 0.0051
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0111 0.066 0.0634
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Echinococcus granulosus heat shock protein 90 0.0025 0.006 0.0032
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0187 0.0159
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0057 0.0279 0.0252
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0222 0.0163
Schistosoma mansoni potassium channel beta 0.0029 0.009 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0094 0.0066
Loa Loa (eye worm) hypothetical protein 0.0057 0.0279 0.0252
Onchocerca volvulus Huntingtin homolog 0.0119 0.0712 1
Echinococcus multilocularis ferritin 0.0026 0.0064 0.0035
Brugia malayi hypothetical protein 0.0242 0.1572 0.4444
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0094 0.0262
Echinococcus multilocularis Smad4 0.0024 0.0056 0.0027
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0104 0.0402
Onchocerca volvulus 0.0028 0.0078 0.0957
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0251 0.0223
Brugia malayi ecdysteroid receptor 0.003 0.0094 0.0262
Brugia malayi hypothetical protein 0.0026 0.0065 0.018
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0104 0.0471
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0351 0.0324
Echinococcus granulosus intermediate filament protein 0.0028 0.0078 0.0049
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0029 0.009 0.0444
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0111 0.066 0.0634
Echinococcus granulosus voltage gated potassium channel subunit 0.0029 0.009 0.0062
Schistosoma mansoni hypothetical protein 0.0042 0.0176 0.0176
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0064 0.0069
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0094 0.0262

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.0157 uM Displacement of [125I]-BH-CCK8 from CCK1 receptor in Sprague-Dawley rat pancreatic acini after 120 hrs by gamma-counting ChEMBL. 21728335
Inhibition (functional) Antagonist activity at human CCK1 receptor expressed in COS7 cells assessed as inhibition of (Thr,Nle)-CCK9-induced inositol phosphate production using myo-2-[3H]inositol after 60 mins by scintillation counting ChEMBL. 21728335
Ki (binding) = 3.9 nM Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK1 receptor expressed in COS-7 cells after 60 mins by gamma counting ChEMBL. 21728335
Ki (binding) = 15.3 uM Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting ChEMBL. 21728335

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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