Detailed information for compound 1596419

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 441.479 | Formula: C26H23N3O4
  • H donors: 4 H acceptors: 4 LogP: 4.99 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)[C@H](NC(=O)c1ccccc1NC(=O)c1cc2c([nH]1)cccc2)CCc1ccccc1
  • InChi: 1S/C26H23N3O4/c30-24(29-22(26(32)33)15-14-17-8-2-1-3-9-17)19-11-5-7-13-21(19)28-25(31)23-16-18-10-4-6-12-20(18)27-23/h1-13,16,22,27H,14-15H2,(H,28,31)(H,29,30)(H,32,33)/t22-/m1/s1
  • InChiKey: XLWHWNHGNRPPBH-JOCHJYFZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cholecystokinin A receptor Starlite/ChEMBL References
Homo sapiens cholecystokinin B receptor Starlite/ChEMBL References
Rattus norvegicus Cholecystokinin A receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi hypothetical protein Get druggable targets OG5_132882 All targets in OG5_132882
Brugia malayi sulfakinin receptor protein Get druggable targets OG5_132882 All targets in OG5_132882
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132882 All targets in OG5_132882
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Cholecystokinin A receptor   444 aa 385 aa 28.6 %
Echinococcus multilocularis g protein coupled receptor Cholecystokinin A receptor   444 aa 396 aa 23.2 %
Schistosoma mansoni rhodopsin-like orphan GPCR Cholecystokinin A receptor   444 aa 380 aa 24.2 %
Schistosoma japonicum FMRFamide receptor, putative Cholecystokinin A receptor   444 aa 363 aa 21.2 %
Echinococcus multilocularis neuropeptides capa receptor Cholecystokinin A receptor   444 aa 400 aa 21.0 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Cholecystokinin A receptor   444 aa 374 aa 24.6 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Cholecystokinin A receptor   444 aa 364 aa 28.6 %
Echinococcus granulosus g protein coupled receptor Cholecystokinin A receptor   444 aa 399 aa 23.3 %
Echinococcus granulosus orexin receptor type 2 Cholecystokinin A receptor   444 aa 366 aa 23.5 %
Echinococcus granulosus rhodopsin orphan GPCR cholecystokinin A receptor 428 aa 373 aa 19.6 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Cholecystokinin A receptor   444 aa 383 aa 21.7 %
Echinococcus multilocularis serotonin receptor Cholecystokinin A receptor   444 aa 468 aa 22.4 %
Schistosoma mansoni biogenic amine (5HT) receptor Cholecystokinin A receptor   444 aa 362 aa 28.2 %
Echinococcus multilocularis orexin receptor type 2 Cholecystokinin A receptor   444 aa 362 aa 22.4 %
Echinococcus granulosus g protein coupled receptor Cholecystokinin A receptor   444 aa 396 aa 23.5 %
Echinococcus granulosus rhodopsin orphan GPCR Cholecystokinin A receptor   444 aa 363 aa 19.6 %
Schistosoma mansoni amine GPCR Cholecystokinin A receptor   444 aa 412 aa 26.2 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Cholecystokinin A receptor   444 aa 395 aa 24.6 %
Echinococcus multilocularis g protein coupled receptor Cholecystokinin A receptor   444 aa 403 aa 24.1 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Cholecystokinin A receptor   444 aa 379 aa 24.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lysine specific demethylase 5A 0.0067 0.0351 0.0324
Loa Loa (eye worm) histone methyltransferase 0.0036 0.0133 0.0105
Brugia malayi Cytochrome P450 family protein 0.005 0.0233 0.0656
Trichomonas vaginalis aldo/keto reductase, putative 0.0102 0.0594 0.3358
Trichomonas vaginalis diacylglycerol kinase, putative 0.0057 0.0279 0.1518
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0057 0.0279 0.1324
Trichomonas vaginalis sphingosine kinase, putative 0.0057 0.0279 0.1518
Brugia malayi Ceramide kinase 0.0057 0.0279 0.0786
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0226 0.3074
Entamoeba histolytica hypothetical protein 0.0037 0.014 0.0111
Schistosoma mansoni apoferritin-2 0.0026 0.0064 0.0064
Echinococcus multilocularis sphingosine kinase 1 0.1452 1 1
Trichomonas vaginalis sphingosine kinase, putative 0.0057 0.0279 0.1518
Trichomonas vaginalis aldo-keto reductase, putative 0.0029 0.009 0.0414
Schistosoma mansoni hypothetical protein 0.0057 0.0279 0.0279
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0177 0.092
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0094 0.0066
Onchocerca volvulus 0.0102 0.0594 0.8318
Echinococcus multilocularis Niemann Pick C1 protein 0.0144 0.0889 0.0863
Plasmodium vivax heat shock protein 86, putative 0.0031 0.0104 0.1835
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0084 0.0084
Trichomonas vaginalis aldo/keto reductase, putative 0.0102 0.0594 0.3358
Plasmodium falciparum diacylglycerol kinase, putative 0.0057 0.0279 0.6128
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0629 1
Schistosoma mansoni smad1 5 8 and 0.0024 0.0056 0.0056
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0094 0.1191
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0102 0.0594 0.2985
Onchocerca volvulus 0.0115 0.0686 0.9629
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.006 0.0556
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0102 0.0594 0.1676
Plasmodium vivax aldehyde reductase, putative 0.0029 0.009 0.1496
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.0877 0.0877
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0102 0.0594 0.3358
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.011 0.0581
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0226 0.0226
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0094 0.0066
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0086 0.0389
Echinococcus multilocularis aldo keto reductase 0.0102 0.0594 0.0567
Plasmodium vivax diacylglycerol kinase, putative 0.0057 0.0279 0.6047
Echinococcus granulosus lamin dm0 0.0028 0.0078 0.0049
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0137 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0067 0.0274
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0629 0.3172
Echinococcus granulosus expressed conserved protein 0.0095 0.0545 0.0518
Schistosoma mansoni patched 1 0.0043 0.0187 0.0187
Brugia malayi MH1 domain containing protein 0.0024 0.0056 0.0154
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.013 0.0363
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0111 0.066 0.0634
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0036 0.0133 0.0105
Brugia malayi mbt repeat family protein 0.0049 0.0226 0.0636
Brugia malayi steroid hormone receptor 0.003 0.0094 0.0262
Schistosoma mansoni microtubule-associated protein tau 0.0668 0.454 0.454
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0443 0.6732
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0086 0.0414
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0222 0.0163
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0102 0.0594 0.1676
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0023 0.0043 0.0015
Schistosoma mansoni hypothetical protein 0.0042 0.0176 0.0176
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0057 0.0279 0.1387
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0594 0.0567
Loa Loa (eye worm) hypothetical protein 0.0048 0.0222 0.0194
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0629 0.3221
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0067 0.0274
Toxoplasma gondii aldose reductase, putative 0.0102 0.0594 0.4045
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Trypanosoma brucei heat shock protein, putative 0.0031 0.0104 0.0402
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0067 0.0274
Echinococcus granulosus dnaJ subfamily B 0.1218 0.8366 0.8362
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0086 0.1571
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0094 0.0066
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0251 0.3356
Loa Loa (eye worm) hypothetical protein 0.0524 0.3536 0.3518
Entamoeba histolytica alcohol dehydrogenase, putative 0.0029 0.009 0.0062
Schistosoma mansoni thyroid hormone receptor 0.003 0.0094 0.0094
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0443 0.0386
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0137 0.2615
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0065 0.0884
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Loa Loa (eye worm) oxidoreductase 0.0102 0.0594 0.0567
Onchocerca volvulus 0.0048 0.0222 0.3016
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0273 0.0246
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0094 0.0066
Echinococcus granulosus neuropeptide receptor A26 0.0909 0.6216 0.6206
Echinococcus granulosus aldo keto reductase 0.0102 0.0594 0.0567
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0094 0.0066
Schistosoma mansoni hypothetical protein 0.0111 0.066 0.066
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0064 0.0069
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0273 0.0273
Echinococcus multilocularis smad 0.0024 0.0056 0.0027
Schistosoma mansoni endoplasmin 0.0031 0.0104 0.0104
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0102 0.0594 0.3358
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0198 0.0198
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0111 0.066 0.0634
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0029 0.009 0.0444
Echinococcus granulosus voltage gated potassium channel subunit 0.0029 0.009 0.0062
Schistosoma mansoni hypothetical protein 0.0042 0.0176 0.0176
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0094 0.0262
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0064 0.0069
Onchocerca volvulus 0.0028 0.0078 0.0957
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0104 0.0402
Brugia malayi hypothetical protein 0.0026 0.0065 0.018
Brugia malayi ecdysteroid receptor 0.003 0.0094 0.0262
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0251 0.0223
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0104 0.0471
Echinococcus granulosus intermediate filament protein 0.0028 0.0078 0.0049
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0351 0.0324
Onchocerca volvulus Huntingtin homolog 0.0119 0.0712 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0279 0.0252
Brugia malayi hypothetical protein 0.0242 0.1572 0.4444
Echinococcus multilocularis ferritin 0.0026 0.0064 0.0035
Echinococcus multilocularis Smad4 0.0024 0.0056 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0094 0.0262
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0222 0.0163
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0057 0.0279 0.0252
Schistosoma mansoni potassium channel beta 0.0029 0.009 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0094 0.0066
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0057 0.0279 0.1518
Brugia malayi 6-phosphofructokinase 0.0107 0.0629 0.1776
Entamoeba histolytica hypothetical protein 0.0023 0.0043 0.0015
Echinococcus granulosus importin subunit beta 1 0.0028 0.008 0.0051
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0111 0.066 0.0634
Echinococcus granulosus heat shock protein 90 0.0025 0.006 0.0032
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0187 0.0159
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.0588 0.1659
Loa Loa (eye worm) glutaminase 0.0265 0.1729 0.1706
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0629 0.3565
Loa Loa (eye worm) hypothetical protein 0.003 0.0094 0.0066
Echinococcus granulosus geminin 0.0346 0.2292 0.227
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0064 0.0004
Schistosoma mansoni glutaminase 0.0265 0.1729 0.1729
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0629 0.0629
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Trypanosoma brucei aldo-keto reductase, putative 0.0102 0.0594 0.2985
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0351 0.0351
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.011 0.0081
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0057 0.0279 0.0252
Echinococcus granulosus lamin 0.0028 0.0078 0.0049
Echinococcus granulosus heat shock protein 90 0.0031 0.0104 0.0076
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0222 0.0194
Echinococcus granulosus GPCR family 2 0.0111 0.066 0.0634
Echinococcus multilocularis musashi 0.0028 0.0078 0.0049
Echinococcus granulosus expressed protein 0.0026 0.0064 0.0035
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.003 0.0094 0.0066
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.008 0.0271
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.011 0.0081
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0029 0.009 0.0414
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0056 0.0027
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0029 0.0084 0.0056
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0172 0.0757
Onchocerca volvulus 0.0057 0.0279 0.3832
Schistosoma mansoni ferritin light chain 0.0026 0.0064 0.0064
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0056 0.0027
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0137 0.2766
Onchocerca volvulus 0.003 0.0094 0.1191
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0086 0.0058
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0153 0.3139
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0078 0.0049
Entamoeba histolytica aldose reductase, putative 0.0102 0.0594 0.0567
Loa Loa (eye worm) oxidoreductase 0.0102 0.0594 0.0567
Trichomonas vaginalis heat shock protein, putative 0.0025 0.006 0.0235
Mycobacterium tuberculosis Conserved protein 0.1452 1 1
Echinococcus multilocularis lamin 0.0028 0.0078 0.0049
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.1228 0.1203
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0177 0.0149
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0222 0.0163
Echinococcus granulosus Smad4 0.0024 0.0056 0.0027
Trypanosoma brucei aldo/keto reductase, putative 0.0029 0.009 0.0328
Echinococcus multilocularis aldo keto reductase 0.0102 0.0594 0.0567
Loa Loa (eye worm) hypothetical protein 0.0036 0.0137 0.0109
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.011 0.0081
Trypanosoma brucei heat shock protein, putative 0.0031 0.0104 0.0402
Brugia malayi intermediate filament protein 0.0028 0.0078 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0137 0.0109
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0057 0.0279 0.1518
Echinococcus multilocularis expressed conserved protein 0.0095 0.0545 0.0518
Loa Loa (eye worm) latrophilin receptor protein 2 0.0111 0.066 0.0634
Plasmodium falciparum aldo-keto reductase, putative 0.0029 0.009 0.167
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0226 0.0198
Loa Loa (eye worm) hypothetical protein 0.003 0.0094 0.0066
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.0877 0.0851
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0198 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0279 0.1518
Brugia malayi hypothetical protein 0.0037 0.014 0.0391
Echinococcus multilocularis expressed protein 0.0026 0.0064 0.0035
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.1923 1
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0094 0.0066
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.011 0.0081
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0094 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0094 0.0262
Echinococcus multilocularis heat shock protein 90 0.0031 0.0104 0.0076
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.008 0.0367
Echinococcus multilocularis heat shock protein 90 0.0025 0.006 0.0032
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Schistosoma mansoni ferritin 0.0026 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0094 0.0262
Echinococcus granulosus mixed lineage leukemia protein mll 0.0029 0.0084 0.0056
Loa Loa (eye worm) hypothetical protein 0.0057 0.0279 0.0252
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0094 0.0066
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0094 0.0066
Trichomonas vaginalis bmru protein, putative 0.0057 0.0279 0.1518
Onchocerca volvulus 0.0029 0.009 0.114
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0222 0.0624
Loa Loa (eye worm) hypothetical protein 0.0111 0.066 0.0634
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0177 0.3582
Trypanosoma cruzi aldo/keto reductase, putative 0.0029 0.009 0.0397
Onchocerca volvulus 0.0049 0.0229 0.3121
Mycobacterium ulcerans hypothetical protein 0.0029 0.009 0.0031
Echinococcus multilocularis protein patched 0.0043 0.0187 0.0159
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0629 0.0629
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.011 0.0581
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0067 0.0274
Echinococcus granulosus aldo keto reductase 0.0102 0.0594 0.0567
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0086 0.1394
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0064 0.0004
Loa Loa (eye worm) MH2 domain-containing protein 0.0359 0.2386 0.2365
Loa Loa (eye worm) oxidoreductase 0.0102 0.0594 0.0567
Brugia malayi Smad1 0.0024 0.0056 0.0154
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0123 0.0064
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0273 0.0769
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0273 0.0246
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0226 0.0198
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0233 0.0205
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0029 0.009 0.0062
Echinococcus granulosus endoplasmin 0.0025 0.006 0.0032
Schistosoma mansoni pol-related 0.0102 0.0594 0.0594
Brugia malayi Latrophilin receptor protein 2 0.0111 0.066 0.1864
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0443 1
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0629 0.0603
Schistosoma mansoni diacylglycerol kinase theta 0.0057 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.003 0.0094 0.0066
Onchocerca volvulus 0.0102 0.0594 0.8318
Loa Loa (eye worm) hypothetical protein 0.0119 0.0712 0.0685
Trypanosoma cruzi aldo/keto reductase, putative 0.0102 0.0594 0.3035
Echinococcus multilocularis snurportin 1 0.0298 0.1962 0.1939
Echinococcus granulosus snurportin 1 0.0298 0.1962 0.1939
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0443 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.011 0.2123
Echinococcus multilocularis dnaJ subfamily B 0.1218 0.8366 0.8362
Echinococcus multilocularis endoplasmin 0.0025 0.006 0.0032
Loa Loa (eye worm) hypothetical protein 0.003 0.0094 0.0066
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.011 0.0081
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0077 0.0309
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0629 0.0603
Schistosoma mansoni ferritin 0.0026 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0094 0.0262
Echinococcus multilocularis cpg binding protein 0.0121 0.0731 0.0705
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0094 0.0066
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0273 0.0246
Onchocerca volvulus Ceramide kinase 1 homolog 0.0057 0.0279 0.3832
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0849 0.4375
Schistosoma mansoni hypothetical protein 0.0111 0.066 0.066
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0094 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.009 0.0414
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.0849 0.4335
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0104 0.0471
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0177 0.1063
Schistosoma mansoni Smad4 0.0024 0.0056 0.0056
Schistosoma mansoni ferritin 0.0026 0.0064 0.0064
Trichomonas vaginalis ferritin, putative 0.0026 0.0064 0.0258
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0037
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0172 0.0823
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.0588 0.0561
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0104 0.0402
Brugia malayi diacylglycerol kinase 0.0057 0.0279 0.0786
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Loa Loa (eye worm) MBCTL1 0.0056 0.0273 0.0246
Entamoeba histolytica diacylglycerol kinase, putative 0.0057 0.0279 0.0252
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0086 0.0389
Loa Loa (eye worm) hypothetical protein 0.0352 0.2335 0.2313
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Loa Loa (eye worm) endoplasmin 0.0031 0.0104 0.0076
Giardia lamblia Aldose reductase 0.0102 0.0594 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0102 0.0594 0.0537
Trypanosoma brucei heat shock protein, putative 0.0031 0.0104 0.0402
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0198 0.0198
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0594 0.0567
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0094 0.0066
Schistosoma mansoni hypothetical protein 0.0346 0.2292 0.2292
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0056 0.0027
Giardia lamblia Grp94/Hsp90 0.0025 0.006 0.0556
Echinococcus granulosus ceramide kinase 0.0057 0.0279 0.0252
Leishmania major prostaglandin f synthase, putative 0.0102 0.0594 0.2985
Loa Loa (eye worm) hypothetical protein 0.0242 0.1572 0.1548
Trichomonas vaginalis aldo-keto reductase, putative 0.0029 0.009 0.0414
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0094 0.0066
Schistosoma mansoni hypothetical protein 0.024 0.156 0.156
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0629 0.3565
Schistosoma mansoni aldo-keto reductase 0.0102 0.0594 0.0594
Loa Loa (eye worm) acetyltransferase 0.0142 0.0877 0.0851
Schistosoma mansoni endoplasmin 0.0031 0.0104 0.0104
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0056 0.0027
Plasmodium falciparum importin beta, putative 0.0028 0.008 0.1417
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0352 0.2335 0.6601
Schistosoma mansoni thyroid hormone receptor 0.003 0.0094 0.0094
Trypanosoma brucei heat shock protein, putative 0.0031 0.0104 0.0402
Loa Loa (eye worm) hypothetical protein 0.003 0.0094 0.0066
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Echinococcus granulosus hypothetical protein 0.0102 0.0594 0.0567
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0177 0.1063
Schistosoma mansoni ferritin 0.0026 0.0064 0.0064
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0029 0.009 0.0252
Brugia malayi isocitrate dehydrogenase 0.0032 0.011 0.0306
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0443 0.0386
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0222 0.0163
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0086 0.1023
Loa Loa (eye worm) hypothetical protein 0.024 0.156 0.1536
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0094 0.0262
Loa Loa (eye worm) hypothetical protein 0.0036 0.0137 0.0109
Leishmania major diacylglycerol kinase, putative 0.0057 0.0279 0.1324
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.006 0.0237
Leishmania major hypothetical protein, conserved 0.0026 0.0065 0.0194
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0222 0.0194
Brugia malayi hypothetical protein 0.0524 0.3536 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0094 0.0066
Brugia malayi Importin beta-1 subunit 0.0028 0.008 0.0222
Onchocerca volvulus 0.0102 0.0594 0.8318
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0094 0.0094
Plasmodium vivax diacylglycerol kinase, putative 0.0057 0.0279 0.6047
Leishmania major aldo-keto reductase-like protein 0.0102 0.0594 0.2985
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0067 0.0274
Loa Loa (eye worm) hypothetical protein 0.008 0.0443 0.0416
Echinococcus multilocularis ceramide kinase 0.0057 0.0279 0.0252
Schistosoma mansoni apoferritin-2 0.0026 0.0064 0.0064
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0094 0.0094
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0102 0.0594 0.2985
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0111 0.066 0.1864
Schistosoma mansoni cpg binding protein 0.0115 0.0686 0.0686
Brugia malayi glutaminase DH11.1 0.0265 0.1729 0.4888
Entamoeba histolytica diacylglycerol kinase, putative 0.0057 0.0279 0.0252
Trypanosoma cruzi aldo-keto reductase 0.0102 0.0594 0.3035
Schistosoma mansoni ran 0.0021 0.0028 0.0028
Loa Loa (eye worm) CXXC zinc finger family protein 0.0115 0.0686 0.0659
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0222 0.1022
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Schistosoma mansoni aldo-keto reductase 0.0102 0.0594 0.0594
Echinococcus multilocularis aldo keto reductase 0.0102 0.0594 0.0567
Trichomonas vaginalis ran, putative 0.0021 0.0028 0.0051
Loa Loa (eye worm) hypothetical protein 0.0119 0.0712 0.0685
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0102 0.0594 0.3358
Schistosoma mansoni coup transcription factor 0.003 0.0094 0.0094
Loa Loa (eye worm) ceramide kinase 0.0057 0.0279 0.0252
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0077 0.1183
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0244 0.1583 0.1583
Plasmodium falciparum aldehyde reductase, putative 0.0029 0.009 0.167
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0123 0.0064
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0057 0.0279 0.1518
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.014 0.0111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0198 0.017
Brugia malayi MH1 domain containing protein 0.0024 0.0056 0.0154
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0222 0.2848
Loa Loa (eye worm) hypothetical protein 0.1452 1 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0086 0.1394
Schistosoma mansoni smad1 5 8 and 0.0024 0.0056 0.0056
Leishmania major diacylglycerol kinase-like protein 0.0057 0.0279 0.1324
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0094 0.0066
Plasmodium vivax importin-beta 2, putative 0.0028 0.008 0.1238
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Toxoplasma gondii histone lysine methyltransferase SET1 0.0221 0.1426 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0043 0.0136
Trypanosoma brucei diacylglycerol kinase, putative 0.0057 0.0279 0.1324
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.0958 0.0904
Plasmodium falciparum diacylglycerol kinase, putative 0.0057 0.0279 0.6128
Plasmodium vivax endoplasmin, putative 0.0031 0.0104 0.1835
Schistosoma mansoni hypothetical protein 0.0298 0.1962 0.1962
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Toxoplasma gondii heat shock protein HSP90 0.0031 0.0104 0.0545
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0023 0.0043 0.0015
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Mycobacterium tuberculosis Conserved protein 0.0029 0.009 0.0031
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0065 0.1071
Entamoeba histolytica hypothetical protein 0.0037 0.014 0.0111
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0198 0.017
Onchocerca volvulus 0.0049 0.0226 0.3074
Echinococcus granulosus neuropeptide s receptor 0.0909 0.6216 0.6206
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0084 0.0056
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.0877 0.2478
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0629 0.0603
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0046
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0028 0.0077
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0594 0.0567
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0067 0.0274
Brugia malayi Isocitrate dehydrogenase 0.0032 0.011 0.0306
Echinococcus granulosus Diacylglycerol kinase zeta 0.0057 0.0279 0.0252
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.1572 0.1548
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0172 0.0823
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0094 0.0262
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0222 0.0194
Schistosoma mansoni survival motor neuron protein 0.0049 0.0229 0.0229
Schistosoma mansoni hypothetical protein 0.1218 0.8366 0.8366
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0104 0.0496
Trichomonas vaginalis aldo/keto reductase, putative 0.0102 0.0594 0.3358
Brugia malayi Eye-specific diacylglycerol kinase 0.0057 0.0279 0.0786
Onchocerca volvulus 0.0028 0.0078 0.0957
Schistosoma mansoni hypothetical protein 0.0042 0.0176 0.0176
Trypanosoma brucei heat shock protein, putative 0.0031 0.0104 0.0402
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.006 0.0166
Brugia malayi diacylglycerol kinase 0.0057 0.0279 0.0786
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0056 0.0027
Trichomonas vaginalis heat shock protein, putative 0.0025 0.006 0.0235
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0043 0.0148
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0094 0.0094
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.011 0.0498
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0443 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0254 0.0227
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0086 0.0464
Brugia malayi Endoplasmin precursor 0.0031 0.0104 0.0292
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0443 1
Mycobacterium leprae Possible oxidoreductase 0.0029 0.009 0.0538
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0028 0.0205
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0222 0.2848
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0086 0.0414
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0102 0.0594 0.1676
Schistosoma mansoni hypothetical protein 0.0042 0.0176 0.0176
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0057 0.0279 0.1387
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0094 0.0094
Leishmania major hypothetical protein, conserved 0.0057 0.0279 0.1324
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0057 0.0279 0.0252
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0594 0.0567
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0064 0.0004
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0086 0.0389
Echinococcus multilocularis lamin dm0 0.0028 0.0078 0.0049
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0137 0.1418
Brugia malayi Calcitonin receptor-like protein seb-1 0.0352 0.2335 0.6601
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0094 0.0066
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Trypanosoma brucei heat shock protein, putative 0.0031 0.0104 0.0402
Echinococcus multilocularis neuropeptide receptor A26 0.0909 0.6216 0.6206
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0057 0.0279 0.0252
Loa Loa (eye worm) heat shock protein 90 0.0031 0.0104 0.0076
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.011 0.0081
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0273 0.0246
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0187 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0094 0.0066
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.011 0.011
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0222 0.1022
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0222 0.1022
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0443 0.6732
Schistosoma mansoni ferritin light chain 0.0026 0.0064 0.0064
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0043 0.0136
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0172 0.0823
Trypanosoma brucei heat shock protein, putative 0.0031 0.0104 0.0402
Echinococcus multilocularis Diacylglycerol kinase theta 0.0057 0.0279 0.0252
Loa Loa (eye worm) hypothetical protein 0.0056 0.0273 0.0246
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0086 0.1571
Onchocerca volvulus Huntingtin homolog 0.0119 0.0712 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0094 0.0066
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0629 0.0603
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0226 0.0226
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.1572 0.1548
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.0598 0.0598
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0065 0.0264
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0065 0.0194
Loa Loa (eye worm) hypothetical protein 0.0049 0.0226 0.0198
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0094 0.0262
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.1962 0.1939
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0094 0.0066
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0067 0.0274
Mycobacterium ulcerans glutaminase 0.0265 0.1729 0.1679
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0187 0.0977
Entamoeba histolytica diacylglycerol kinase, putative 0.0057 0.0279 0.0252
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0594 0.0567
Trypanosoma cruzi Sphingosine kinase 0.0057 0.0279 0.1387
Brugia malayi latrophilin 2 splice variant baaae 0.024 0.156 0.4408
Brugia malayi CXXC zinc finger family protein 0.0115 0.0686 0.1936
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0094 0.0066
Schistosoma mansoni sphingosine kinase A B 0.1452 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0222 0.0163
Brugia malayi hypothetical protein 0.0119 0.0712 0.201
Loa Loa (eye worm) hypothetical protein 0.003 0.0094 0.0066
Brugia malayi jmjC domain containing protein 0.0067 0.0351 0.0989
Schistosoma mansoni hypothetical protein 0.0037 0.014 0.014
Leishmania major importin beta-1 subunit, putative 0.0023 0.0043 0.0077
Echinococcus granulosus Niemann Pick C1 protein 0.0144 0.0889 0.0863
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0043 0.0187 0.0159
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0251 0.0192
Echinococcus granulosus FTZ F1 alpha 0.003 0.0094 0.0066
Schistosoma mansoni heat shock protein 0.0031 0.0104 0.0104
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0849 0.4335
Toxoplasma gondii hypothetical protein 0.0028 0.0077 0.0351
Brugia malayi hypothetical protein 0.0057 0.0279 0.0786
Loa Loa (eye worm) diacylglycerol kinase 2 0.0057 0.0279 0.0252
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0305 0.0278
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0104 0.0471
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0065 0.0264
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0067 0.0274
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0443 0.0443
Schistosoma mansoni hypothetical protein 0.0049 0.0229 0.0229
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0198 0.017
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.1923 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0198 0.017
Echinococcus multilocularis GPCR, family 2 0.0111 0.066 0.0634
Mycobacterium leprae Conserved hypothetical protein 0.0072 0.0388 0.5772
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0629 0.0603
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0094 0.0262
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0056 0.0027
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0102 0.0594 0.9376
Loa Loa (eye worm) hypothetical protein 0.0102 0.0594 0.0567
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0443 0.2968
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.1923 1
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0094 0.1191
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0094 0.0094
Echinococcus multilocularis protein dispatched 1 0.0049 0.0229 0.0201
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0831 0.5671 0.5658
Loa Loa (eye worm) hypothetical protein 0.0101 0.0588 0.0561
Schistosoma mansoni jumonji domain containing protein 0.006 0.0305 0.0305
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0057 0.0279 0.0279
Schistosoma mansoni hypothetical protein 0.0111 0.066 0.066
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0067 0.0274
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0629 0.3172
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0064 0.0103
Loa Loa (eye worm) hypothetical protein 0.0057 0.0279 0.0252
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0137 0.0077
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0594 0.0567
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.0588 0.0561
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Brugia malayi sulfakinin receptor protein 0.0524 0.3536 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0198 0.0198
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0629 1
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.1923 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0352 0.2335 0.2313
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.006 0.0032
Schistosoma mansoni cpg binding protein 0.0121 0.0731 0.0731
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0067 0.0274
Brugia malayi phosphofructokinase 0.0107 0.0629 0.1776
Echinococcus granulosus ferritin 0.0026 0.0064 0.0035
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0251 0.0192
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Loa Loa (eye worm) hypothetical protein 0.0028 0.008 0.0051
Toxoplasma gondii heat shock protein 90, putative 0.0031 0.0104 0.0545
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0056 0.0056
Entamoeba histolytica aldose reductase, putative 0.0102 0.0594 0.0567
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0104 0.0076
Echinococcus granulosus microtubule associated protein 2 0.0668 0.454 0.4525
Onchocerca volvulus 0.0102 0.0594 0.8318
Toxoplasma gondii aldo-keto reductase 0.0029 0.009 0.0444
Brugia malayi RNA, U transporter 1 0.0079 0.0438 0.1236
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0067 0.0274
Mycobacterium ulcerans hypothetical protein 0.0048 0.0222 0.0163
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0153 0.0125
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Trypanosoma cruzi Heat shock protein 83, putative 0.0031 0.0104 0.0471
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0094 0.0262
Loa Loa (eye worm) hypothetical protein 0.0048 0.0222 0.0194
Trypanosoma cruzi Sphingosine kinase 0.0057 0.0279 0.1387
Schistosoma mansoni cpg binding protein 0.0121 0.0731 0.0731
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.006 0.0237
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0279 0.1387
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0057 0.0279 0.1795
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0065 0.1071
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0234 0.1152
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0187 0.0159
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0629 0.0603
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0849 0.0823
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0629 0.0573
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0104 0.0076
Brugia malayi Diacylglycerol kinase protein 2 0.0057 0.0279 0.0786
Entamoeba histolytica alcohol dehydrogenase, putative 0.0029 0.009 0.0062
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0057 0.0279 0.1795
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0443 0.2968
Plasmodium falciparum heat shock protein 90 0.0031 0.0104 0.2002
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0226 0.0198
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.011 0.0429
Trichomonas vaginalis aldo-keto reductase, putative 0.0029 0.009 0.0414
Trichomonas vaginalis bmru protein, putative 0.0057 0.0279 0.1518
Echinococcus multilocularis heat shock protein 0.0031 0.0104 0.0076
Echinococcus granulosus aldehyde reductase 0.0072 0.0388 0.0361
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0086 0.0414
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0057 0.0279 0.1387
Leishmania major hypothetical protein, conserved 0.0057 0.0279 0.1324
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0086 0.0389
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0067 0.0274
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0094 0.0066
Giardia lamblia Aldose reductase 0.0102 0.0594 1
Trichomonas vaginalis heat shock protein, putative 0.0025 0.006 0.0235
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0086 0.0389
Entamoeba histolytica hypothetical protein 0.0037 0.014 0.0111
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0029 0.009 0.0328
Echinococcus granulosus cpg binding protein 0.0121 0.0731 0.0705
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.008 0.0271
Echinococcus multilocularis aldehyde reductase 0.0072 0.0388 0.0361
Loa Loa (eye worm) hypothetical protein 0.0048 0.0222 0.0194
Loa Loa (eye worm) oxidoreductase 0.0102 0.0594 0.0567
Toxoplasma gondii diacylglycerol kinase, putative 0.0057 0.0279 0.1795
Loa Loa (eye worm) glutaminase 2 0.0265 0.1729 0.1706
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0443 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0067 0.0274
Trichomonas vaginalis glutaminase, putative 0.0265 0.1729 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.1228 0.1203
Schistosoma mansoni hypothetical protein 0.0111 0.066 0.066
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0251 0.0223
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0094 0.0262
Brugia malayi 6-phosphofructokinase 0.0107 0.0629 0.1776
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0029 0.009 0.0444
Brugia malayi MH2 domain containing protein 0.0024 0.0056 0.0154
Echinococcus multilocularis geminin 0.0346 0.2292 0.227
Schistosoma mansoni smad1 5 8 and 0.0024 0.0056 0.0056
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0187 0.0159
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.011 0.0498
Loa Loa (eye worm) hypothetical protein 0.0036 0.0137 0.0109
Schistosoma mansoni intermediate filament proteins 0.0028 0.0078 0.0078
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0222 0.0624
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0111 0.066 0.0634
Echinococcus multilocularis voltage gated potassium channel subunit 0.0029 0.009 0.0062
Brugia malayi CHE-14 protein 0.0043 0.0187 0.0524
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.011 0.0429
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0102 0.0594 0.1676
Schistosoma mansoni heat shock protein 0.0031 0.0104 0.0104
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.0104 0.1346
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0198 0.0556
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0094 0.0066
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0222 0.0163
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0094 0.0094
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0094 0.0066
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0226 0.0198
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0443 0.0416
Echinococcus granulosus smad 0.0024 0.0056 0.0027
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0222 0.0163
Schistosoma mansoni smad 0.0024 0.0056 0.0056
Echinococcus granulosus aldo keto reductase 0.0102 0.0594 0.0567
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0067 0.0274
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0078 0.0216
Onchocerca volvulus 0.0102 0.0594 0.8318
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.011 0.005
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0222 0.0624
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0065 0.0262
Echinococcus multilocularis neuropeptide s receptor 0.0909 0.6216 0.6206
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0064 0.0004
Schistosoma mansoni importin beta-1 0.0028 0.008 0.008
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0629 0.0603
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0067 0.0274
Brugia malayi jmjC domain containing protein 0.006 0.0305 0.086
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0629 0.0603
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.011 0.1959
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0094 0.0262
Loa Loa (eye worm) hypothetical protein 0.003 0.0094 0.0066
Loa Loa (eye worm) oxidoreductase 0.0102 0.0594 0.0567
Mycobacterium tuberculosis Diacylglycerol kinase 0.0057 0.0279 0.0221
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0229 0.0645
Trypanosoma brucei heat shock protein, putative 0.0031 0.0104 0.0402
Brugia malayi nuclear hormone receptor 0.003 0.0094 0.0262
Schistosoma mansoni hypothetical protein 0.0346 0.2292 0.2292
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0028 0.0072
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.014 0.0111
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0094 0.0066
Trypanosoma cruzi diacylglycerol kinase, putative 0.0057 0.0279 0.1387
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0029 0.009 0.1496
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0305 0.0278
Mycobacterium ulcerans diacylglycerol kinase 0.0057 0.0279 0.0221
Schistosoma mansoni ran 0.0021 0.0028 0.0028
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0077 0.1363
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0043 0.0136
Trichomonas vaginalis aldo-keto reductase, putative 0.0102 0.0594 0.3358
Brugia malayi heat shock protein 90 0.0031 0.0104 0.0292
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0029 0.009 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0094 0.0262
Echinococcus multilocularis microtubule associated protein 2 0.0668 0.454 0.4525
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0036 0.0133 0.0105
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0222 0.0163
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0077 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0067 0.0274
Schistosoma mansoni hypothetical protein 0.0297 0.1957 0.1957
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0123 0.0064
Mycobacterium ulcerans hypothetical protein 0.1452 1 1
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.0588 0.0561
Entamoeba histolytica diacylglycerol kinase, putative 0.0057 0.0279 0.0252
Brugia malayi nuclear receptor NHR-88 0.003 0.0094 0.0262
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0305 0.0278
Trichomonas vaginalis helicase, putative 0.0026 0.0067 0.0274
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0629 0.3565
Schistosoma mansoni lamin 0.0028 0.0078 0.0078
Trypanosoma brucei Sphingosine kinase 0.0057 0.0279 0.1324
Loa Loa (eye worm) hypothetical protein 0.0028 0.0078 0.0049
Toxoplasma gondii hypothetical protein 0.0047 0.0214 0.1327
Brugia malayi MH2 domain containing protein 0.0024 0.0056 0.0154
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0226 0.0198
Leishmania major sphingosine kinase A, B, putative 0.0057 0.0279 0.1324
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0123 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0094 0.0262
Trichomonas vaginalis diacylglycerol kinase, putative 0.0057 0.0279 0.1518
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0443 0.0416
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0094 0.1191
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0629 0.0573
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0094 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0094 0.0066
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0594 0.0567
Brugia malayi MH2 domain containing protein 0.0359 0.2386 0.6747
Mycobacterium ulcerans oxidoreductase 0.0102 0.0594 0.0537
Echinococcus multilocularis aldo keto reductase 0.0102 0.0594 0.0567
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0094 0.0066
Mycobacterium ulcerans hypothetical protein 0.0154 0.0958 0.0904
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0057 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0036 0.0137 0.0109
Entamoeba histolytica hypothetical protein, conserved 0.1452 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0594 0.0567
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0094 0.0262
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0629 0.3565
Echinococcus granulosus Diacylglycerol kinase theta 0.0057 0.0279 0.0252
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0102 0.0594 0.0567
Echinococcus granulosus heat shock protein 0.0031 0.0104 0.0076
Entamoeba histolytica hypothetical protein 0.0037 0.014 0.0111
Loa Loa (eye worm) transcription factor SMAD2 0.0359 0.2386 0.2365
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0078 0.0049
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0086 0.0389
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0104 0.0471
Echinococcus multilocularis importin subunit beta 1 0.0028 0.008 0.0051
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0222 0.0163
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0028 0.0072
Leishmania major heat shock protein 83-1 0.0031 0.0104 0.0402
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0153 0.2198
Brugia malayi NADH-dependent xylose reductase 0.0029 0.009 0.0252
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.014 0.014
Trypanosoma brucei hypothetical protein, conserved 0.0057 0.0279 0.1324
Schistosoma mansoni sphingoid long chain base kinase 0.1452 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0067 0.0274
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0102 0.0594 0.0567
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.011 0.0081
Trypanosoma brucei Heat shock protein 83, putative 0.0031 0.0104 0.0402
Loa Loa (eye worm) Smad1 0.0024 0.0056 0.0027
Brugia malayi mbt repeat family protein 0.0049 0.0226 0.0636
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0086 0.0389
Trypanosoma cruzi diacylglycerol kinase, putative 0.0057 0.0279 0.1387
Entamoeba histolytica aldose reductase, putative 0.0102 0.0594 0.0567
Schistosoma mansoni nuclear hormone receptor 0.003 0.0094 0.0094
Schistosoma mansoni diacylglycerol kinase theta 0.0057 0.0279 0.0279
Brugia malayi Probable ClpP-like protease 0.008 0.0443 0.125
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.011 0.0429
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0084 0.0056
Onchocerca volvulus 0.0102 0.0594 0.8318
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0177 0.092
Trypanosoma brucei prostaglandin f synthase 0.0102 0.0594 0.2985
Schistosoma mansoni lamin 0.0028 0.0078 0.0078

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.0095 uM Displacement of [125I]-BH-CCK8 from CCK1 receptor in Sprague-Dawley rat pancreatic acini after 120 hrs by gamma-counting ChEMBL. 21728335
Inhibition (functional) Antagonist activity at human CCK1 receptor expressed in COS7 cells assessed as inhibition of (Thr,Nle)-CCK9-induced inositol phosphate production using myo-2-[3H]inositol after 60 mins by scintillation counting ChEMBL. 21728335
Ki (binding) = 0.32 nM Displacement of [125I]-BH-JMV-179 from wild type human CCK1 receptor expressed in COS7 cells after 60 mins by gamma counting ChEMBL. 21728335
Ki (binding) = 2.3 nM Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK1 receptor expressed in COS-7 cells after 60 mins by gamma counting ChEMBL. 21728335
Ki (binding) = 5.8 nM Displacement of [3H]-SR-27897 from wild type human CCK1 receptor expressed in COS7 cells after 60 mins by gamma counting ChEMBL. 21728335
Ki (binding) = 1 uM Displacement of [125I]BH-(Thr,-Nle)-CCK-9 from human CCK2 receptor expressed in COS-7 cells after 60 mins by gamma counting ChEMBL. 21728335

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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