Detailed information for compound 1644994

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 365.386 | Formula: C19H19N5O3
  • H donors: 0 H acceptors: 3 LogP: 0.51 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCCn1/c(=N/C(=O)C)/c(C#N)cc2c1nc1c(C)cccn1c2=O
  • InChi: 1S/C19H19N5O3/c1-12-6-4-7-24-16(12)22-18-15(19(24)26)10-14(11-20)17(21-13(2)25)23(18)8-5-9-27-3/h4,6-7,10H,5,8-9H2,1-3H3/b21-17+
  • InChiKey: PNXHMGMTACKGTL-HEHNFIMWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0947 0.1868 0.1862
Brugia malayi RNA, U transporter 1 0.0099 0.017 0.0169
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0142 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.011 0.0109
Brugia malayi hypothetical protein 0.0039 0.005 0.0049
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0084 0.1336
Schistosoma mansoni peptidase Clp (S14 family) 0.0085 0.0142 0.0141
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.003 0.0475
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0112 0.0195 0.0195
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0596 0.0595
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0323 0.0619 0.0619
Loa Loa (eye worm) hypothetical protein 0.1021 0.2015 0.2015
Echinococcus multilocularis snurportin 1 0.0372 0.0716 0.0716
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0023 0.0022
Brugia malayi Muscleblind-like protein 0.018 0.0333 0.0332
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0008 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0624 0.1221 0.122
Trichomonas vaginalis PIKK family atypical protein kinase 0.2704 0.5387 0.5386
Trichomonas vaginalis PIKK family atypical protein kinase 0.3725 0.743 0.743
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0947 0.1868 0.1867
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0323 0.0619 0.0831
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0323 0.0619 0.0618
Loa Loa (eye worm) hypothetical protein 0.0054 0.008 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.3984 0.7948 0.7948
Trichomonas vaginalis PIKK family atypical protein kinase 0.4276 0.8534 0.8533
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0023 0.0022
Loa Loa (eye worm) phosphatidylinositol 3 0.0323 0.0619 0.0619
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0007
Schistosoma mansoni immunophilin 0.0058 0.0087 0.0086
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0544 0.0543
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0043 0.0671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0323 0.0619 0.0618
Echinococcus multilocularis lamin dm0 0.0029 0.0031 0.0031
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0016 0.0016
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0323 0.0619 0.0619
Schistosoma mansoni tar DNA-binding protein 0.0069 0.011 0.0109
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0015 0.0001 0.0001
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0323 0.0619 0.0611
Leishmania major GTP-binding protein, putative 0.0026 0.0023 0.0022
Entamoeba histolytica hypothetical protein 0.0323 0.0619 0.0611
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0403 0.0402
Echinococcus multilocularis Zinc finger, PHD finger 0.0323 0.0619 0.0619
Echinococcus granulosus serine/threonine protein kinase 0.0023 0.0018 0.0018
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0323 0.0619 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.2963 0.5904 0.5904
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0323 0.0619 0.0611
Onchocerca volvulus 0.0286 0.0544 0.8797
Echinococcus multilocularis nervana 2 0.0021 0.0013 0.0013
Giardia lamblia Kinase, AGC PKA 0.0021 0.0014 0.0013
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0058 0.0087 0.0086
Onchocerca volvulus 0.0054 0.008 0.1272
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.005 0.0071 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.2993 0.5964 0.5963
Trichomonas vaginalis conserved hypothetical protein 0.0732 0.1438 0.1437
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0234 0.0233
Brugia malayi Importin beta-1 subunit 0.0035 0.0041 0.004
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0323 0.0619 0.0618
Loa Loa (eye worm) hypothetical protein 0.003 0.0032 0.0032
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0058 0.0087 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.5008 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0381 0.038
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.0111 0.011
Leishmania major phosphatidylinositol 3-kinase, putative 0.0323 0.0619 0.0618
Loa Loa (eye worm) hypothetical protein 0.0947 0.1868 0.1868
Echinococcus granulosus snurportin 1 0.0372 0.0716 0.0716
Leishmania major phosphatidylinositol 3-kinase, putative 0.168 0.3335 0.3334
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0947 0.1868 0.1867
Trichomonas vaginalis PIKK family atypical protein kinase 0.5008 1 1
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0008 0.0114
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0084 0.0084
Leishmania major cathepsin L-like protease 0.0018 0.0008 0.0007
Entamoeba histolytica hypothetical protein 0.0947 0.1868 0.1862
Entamoeba histolytica hypothetical protein 0.0039 0.005 0.0042
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0085 0.0142 0.0142
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0323 0.0619 0.0618
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0085 0.0142 0.0142
Schistosoma mansoni hypothetical protein 0.0039 0.005 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0111 0.011
Echinococcus multilocularis hyperpolarization activated cyclic 0.0022 0.0016 0.0016
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0028 0.0027
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0015 0.0002 0.0001
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1055 0.2085 0.2805
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.0234 0.3778
Loa Loa (eye worm) hypothetical protein 0.018 0.0333 0.0333
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0381 0.038
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0031 0.0031
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0323 0.0619 0.0619
Leishmania major phosphatidylinositol kinase related protein, putative 0.0323 0.0619 0.0618
Plasmodium vivax hypothetical protein 0.0323 0.0619 1
Echinococcus multilocularis geminin 0.0205 0.0381 0.0381
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0041 0.004
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.168 0.3335 0.3334
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0947 0.1868 0.1867
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0022 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0007
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0732 0.1438 0.1438
Leishmania major fk506-binding protein 1-like protein 0.0058 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0029
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0043 0.2931
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0028 0.0027
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0381 0.038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0111 0.011
Schistosoma mansoni tar DNA-binding protein 0.0069 0.011 0.0109
Plasmodium vivax vivapain-2 0.0018 0.0008 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.2993 0.5964 0.5963
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.27 0.5378 0.5378
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0032 0.0508
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.168 0.3335 0.3335
Loa Loa (eye worm) phosphatidylinositol 3 0.0323 0.0619 0.0619
Echinococcus multilocularis cysteine protease 0.0018 0.0008 0.0008
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.0043 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.3725 0.743 0.743
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0015 0.0002 0.0002
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0018 0.001
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0008 0.0008
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0234 0.0233
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0234 0.0233
Leishmania major phosphatidylinositol kinase, putative 0.0323 0.0619 0.0618
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0111 0.011
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.005 0.005
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0018 0.001
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0032 0.0035 0.0035
Echinococcus multilocularis fk506 binding protein 0.0058 0.0087 0.0087
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0058 0.0087 0.0086
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0596 0.0595
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0032 0.0031
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0023 0.0352
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5008 1 1
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0234 0.0226
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0032 0.0042
Entamoeba histolytica protein kinase, putative 0.0032 0.0035 0.0027
Loa Loa (eye worm) AGC/PKG protein kinase 0.0015 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0044 0.0044
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0023 0.0023
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0111 0.011
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0043 0.0041
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0021 0.0013 0.0013
Loa Loa (eye worm) FKBP5 protein 0.0058 0.0087 0.0087
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0058 0.0087 0.0086
Brugia malayi hypothetical protein 0.003 0.0032 0.0031
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5008 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0323 0.0619 0.0611
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0142 0.019
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.0596 0.0595
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0008 0.0007
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0058 0.0087 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0007
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0323 0.0619 1
Plasmodium vivax SET domain protein, putative 0.0036 0.0044 0.069
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0142 0.6061
Echinococcus granulosus serine threonine protein kinase nrc 0.0021 0.0014 0.0014
Loa Loa (eye worm) AGC/AKT protein kinase 0.0034 0.0039 0.0039
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.011 0.0109
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0323 0.0619 0.0618
Echinococcus multilocularis musashi 0.0029 0.0031 0.0031
Loa Loa (eye worm) fibroinase 0.0018 0.0008 0.0008
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5008 1 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.168 0.3335 0.3334
Loa Loa (eye worm) phosphatidylinositol 3 0.0323 0.0619 0.0619
Loa Loa (eye worm) hypothetical protein 0.0624 0.1221 0.1221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0007
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0043 0.0041
Echinococcus granulosus intermediate filament protein 0.0029 0.0031 0.0031
Schistosoma mansoni immunophilin 0.005 0.0071 0.007
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.0099 0.0098
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0234 0.0226
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.208 0.4137 0.4136
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0031 0.0029
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0323 0.0619 0.0619
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0039 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.5008 1 1
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0323 0.0619 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0032 0.0036 0.0036
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.003 0.1258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0007
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0041 0.004
Echinococcus granulosus importin subunit beta 1 0.0035 0.0041 0.0041
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.0234 1
Loa Loa (eye worm) hypothetical protein 0.0323 0.0619 0.0619
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0044 0.0057
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0323 0.0619 0.0618
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0015 0.0002 0.0002
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.003 0.0475
Brugia malayi TAR-binding protein 0.0069 0.011 0.0109
Loa Loa (eye worm) hypothetical protein 0.0085 0.0142 0.0142
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0007
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.0381 0.6157
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0323 0.0619 0.0618
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0021 0.0014 0.0207
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0323 0.0619 0.0618
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0007
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0032 0.0036 0.0035
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0043 0.0041
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5008 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0323 0.0619 0.0611
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0022 0.0016 0.0016
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0323 0.0619 0.0618
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0016 0.0015
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.168 0.3335 0.3334
Loa Loa (eye worm) hypothetical protein 0.0097 0.0166 0.0166
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0031
Plasmodium falciparum cGMP-dependent protein kinase 0.0015 0.0002 0.0008
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0058 0.0087 0.0087
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0032 0.0031
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0323 0.0619 0.0619
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0234 0.0233
Giardia lamblia Phosphatidylinositol 4-kinase 0.0323 0.0619 0.0618
Loa Loa (eye worm) hypothetical protein 0.0035 0.0041 0.0041
Trichomonas vaginalis ran, putative 0.0026 0.0023 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.3984 0.7948 0.7948
Trypanosoma cruzi Protein kinase B 0.0023 0.0018 0.0017
Brugia malayi Protein kinase domain containing protein 0.0034 0.0039 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0111 0.011
Onchocerca volvulus 0.0323 0.0619 1
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0058 0.0087 0.0086
Brugia malayi 6-phosphofructokinase 0.0131 0.0234 0.0233
Mycobacterium leprae conserved hypothetical protein 0.0323 0.0619 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3984 0.7948 0.7948
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0323 0.0619 1
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0021 0.0014 0.0207
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0323 0.0619 0.0619
Plasmodium vivax vivapain-2 0.0018 0.0008 0.0114
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0008 0.0114
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0015 0.0001 0.0001
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0323 0.0619 0.0618
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0043 0.0041
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0216 0.0215
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0016 0.0016
Brugia malayi Cathepsin L-like precursor 0.0018 0.0008 0.0007
Schistosoma mansoni hypothetical protein 0.0205 0.0381 0.038
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0234 0.0226
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0039 0.0038
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5008 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0111 0.011
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0323 0.0619 0.0618
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0381 0.038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0016 0.0016
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0323 0.0619 0.0611
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0003 0.0002
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0142 0.229
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0081 0.008
Echinococcus granulosus cGMP dependent protein kinase 1 0.0015 0.0002 0.0002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0028 0.0027
Leishmania major cathepsin L-like protease 0.0018 0.0008 0.0007
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0022 0.0016 0.0016
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5008 1 1
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0058 0.0087 0.3688
Schistosoma mansoni importin beta-1 0.0035 0.0041 0.004
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0015 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.2993 0.5964 0.5963
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0323 0.0619 0.0619
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0015 0.0001 0.0001
Echinococcus granulosus geminin 0.0205 0.0381 0.0381
Echinococcus multilocularis tumor protein p63 0.0369 0.071 0.071
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0039 0.0038
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0084 0.0084
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5008 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0016 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.3725 0.743 0.743
Echinococcus multilocularis Glutaredoxin protein 5 0.0021 0.0013 0.0013
Echinococcus multilocularis 0.0323 0.0619 0.0619
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0085 0.0142 0.229
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0022 0.0016 0.0016
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0058 0.0087 0.0087
Echinococcus granulosus lamin dm0 0.0029 0.0031 0.0031
Toxoplasma gondii AGC kinase 0.0032 0.0035 0.0046
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0323 0.0619 0.0618
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0023 0.0022
Leishmania major importin beta-1 subunit, putative 0.0028 0.0028 0.0027
Entamoeba histolytica hypothetical protein 0.0039 0.005 0.0042
Echinococcus granulosus Glutaredoxin protein 5 0.0021 0.0013 0.0013
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0058 0.0087 0.0086
Schistosoma mansoni microtubule-associated protein tau 0.0753 0.148 0.1479
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0007
Entamoeba histolytica hypothetical protein 0.0039 0.005 0.0042
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0323 0.0619 0.0611
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0015 0.0001 0.0001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0323 0.0619 0.0618
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0032 0.0036 0.0036
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0058 0.0087 0.0086
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0021 0.0014 0.0014
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0022 0.0016 0.0016
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0058 0.0087 0.0086
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.0596 0.0596
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0058 0.0087 0.0086
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.168 0.3335 0.3335
Toxoplasma gondii FATC domain-containing protein 0.0947 0.1868 0.2513
Loa Loa (eye worm) RNA binding protein 0.0069 0.011 0.011
Onchocerca volvulus 0.0018 0.0008 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.2704 0.5387 0.5386
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0323 0.0619 0.0618
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0111 0.011
Leishmania major hypothetical protein, conserved 0.0323 0.0619 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.27 0.5378 0.5378
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.005 0.0049
Echinococcus granulosus voltage gated potassium channel 0.0032 0.0036 0.0036
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0041 0.0054
Onchocerca volvulus 0.0018 0.0008 0.0114
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0716 0.0716
Trichomonas vaginalis PIKK family atypical protein kinase 0.3725 0.743 0.743
Echinococcus granulosus muscleblind protein 0.018 0.0333 0.0333
Leishmania major cathepsin L-like protease 0.0018 0.0008 0.0007
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0058 0.0087 0.1393
Echinococcus multilocularis voltage gated potassium channel 0.0032 0.0036 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0007
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0112 0.0195 0.0195
Schistosoma mansoni lamin 0.0029 0.0031 0.0029
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0142 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0475 0.0475
Leishmania major cathepsin L-like protease 0.0018 0.0008 0.0007
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.0043 0.0034
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0008 0.0008
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0947 0.1868 0.1868
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Brugia malayi Pre-SET motif family protein 0.0251 0.0475 0.0474
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0084 0.1336
Schistosoma mansoni 60S ribosomal protein L21 0.0018 0.0007 0.0006
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0323 0.0619 0.0619
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.003 0.0475
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0007
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0036 0.0035
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0023 0.0023
Plasmodium falciparum importin beta, putative 0.0035 0.0041 0.065
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0015 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0044 0.0043
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0058 0.0087 0.1393
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0323 0.0619 0.0618
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0007
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0043 0.0671
Schistosoma mansoni tar DNA-binding protein 0.0069 0.011 0.0109
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0016 0.0015
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.005 0.0071 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.1344 0.2662 0.2661
Brugia malayi Probable ClpP-like protease 0.0085 0.0142 0.0141
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0043 0.0041
Brugia malayi Cathepsin L-like precursor 0.0018 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.2963 0.5904 0.5904
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0142 0.6061
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0323 0.0619 0.0618
Loa Loa (eye worm) hypothetical protein 0.0732 0.1438 0.1438
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0007
Echinococcus granulosus cGMP dependent protein kinase 1 0.0015 0.0002 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0039 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0008 0.0007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0007
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0043 0.0671
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0111 0.011
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0058 0.0087 0.0079
Echinococcus multilocularis microtubule associated protein 2 0.0753 0.148 0.148
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0015 0.0001 0.0001
Leishmania major peptidylprolyl isomerase-like protein 0.0058 0.0087 0.0086
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0016 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0007
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0003 0.0003
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0043 0.0041
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0323 0.0619 0.0619
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0323 0.0619 0.0618
Echinococcus multilocularis expressed conserved protein 0.0015 0.0002 0.0002
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5008 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0323 0.0619 0.0619
Trichomonas vaginalis PIKK family atypical protein kinase 0.168 0.3335 0.3334
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0043 0.0671
Echinococcus granulosus nervana 2 0.0021 0.0013 0.0013
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0323 0.0619 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.27 0.5378 0.5378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0624 0.1221 0.122
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0018 0.0017
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0085 0.0142 0.229
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0015 0.0001 0.0001
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0323 0.0619 0.0618
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0732 0.1438 0.1438
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.005 0.005
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0323 0.0619 0.0619
Echinococcus granulosus tumor protein p63 0.0369 0.071 0.071
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0323 0.0619 0.0618
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0381 0.038
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0323 0.0619 0.0618
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0039 0.0038
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.0234 0.0233
Echinococcus granulosus lamin 0.0029 0.0031 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.3725 0.743 0.743
Trichomonas vaginalis PIKK family atypical protein kinase 0.2704 0.5387 0.5386
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0323 0.0619 0.0618
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0023 0.0029
Onchocerca volvulus 0.0018 0.0008 0.0114
Echinococcus granulosus tar DNA binding protein 0.0069 0.011 0.011
Schistosoma mansoni lamin 0.0029 0.0031 0.0029
Echinococcus granulosus patatin phospholipase domain containing protein 0.0015 0.0001 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0381 0.038
Brugia malayi FAT domain containing protein 0.0732 0.1438 0.1437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0007
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0008 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0044 0.0043
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0016 0.0015
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0234 0.0234
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0058 0.0087 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0007
Brugia malayi Cathepsin L-like precursor 0.0018 0.0008 0.0007
Schistosoma mansoni fkbp-rapamycin associated protein 0.0947 0.1868 0.1867
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0234 0.0233
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.168 0.3335 0.3334
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0008 0.0008
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.0043 0.1777
Trichomonas vaginalis PIKK family atypical protein kinase 0.0323 0.0619 0.0618
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0031 0.0031
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0058 0.0087 0.0086
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3988 0.7956 0.7956
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0008 0.0007
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0021 0.0013 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0596 0.0595
Entamoeba histolytica hypothetical protein 0.0028 0.0028 0.002
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0323 0.0619 0.0618
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.008 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0111 0.011
Entamoeba histolytica hypothetical protein 0.0323 0.0619 0.0611
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0323 0.0619 0.0618
Loa Loa (eye worm) phosphatidylinositol 3 0.5008 1 1
Echinococcus multilocularis rac serine:threonine kinase 0.0023 0.0018 0.0018
Toxoplasma gondii cathepsin CPL 0.0018 0.0008 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0947 0.1868 0.1867
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0111 0.011
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0058 0.0087 0.0086
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0323 0.0619 0.0831
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0044 0.0044
Echinococcus multilocularis serine protein kinase ATM 0.0947 0.1868 0.1868
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0043 0.0041
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0008 0.0007
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0041 0.0041
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0058 0.0087 0.3688
Trypanosoma cruzi target of rapamycin kinase 3 0.3988 0.7956 0.7956
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0596 0.0595
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0007
Entamoeba histolytica Ran family GTPase 0.0026 0.0023 0.0015
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5008 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0008 0.0007
Leishmania major cathepsin L-like protease 0.007 0.0111 0.011
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0007 0.0006
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0142 0.6061
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0323 0.0619 0.0618
Trichomonas vaginalis immunophilin, putative 0.0058 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.0323 0.0619 0.0619
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0323 0.0619 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0323 0.0619 0.0618
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0323 0.0619 0.0618
Echinococcus granulosus serine protein kinase ATM 0.0947 0.1868 0.1868
Leishmania major phosphatidylinositol 4-kinase, putative 0.0323 0.0619 0.0618
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0008 0.0114
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.168 0.3335 0.3334
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0323 0.0619 1
Entamoeba histolytica protein kinase, putative 0.0034 0.0039 0.0031
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0112 0.0195 0.0195
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0624 0.1221 0.122
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0008 0.0008
Plasmodium vivax importin-beta 2, putative 0.0035 0.0041 0.065
Schistosoma mansoni hypothetical protein 0.0372 0.0716 0.0715
Leishmania major hypothetical protein, conserved 0.003 0.0032 0.0031
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0323 0.0619 0.0618
Brugia malayi Pre-SET motif family protein 0.0036 0.0044 0.0043
Loa Loa (eye worm) TAR-binding protein 0.0069 0.011 0.011
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0021 0.0014 0.0014
Loa Loa (eye worm) ctsf protein 0.0018 0.0008 0.0008
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0323 0.0619 0.0618
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0104 0.0181 0.018
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0032 0.0508
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0085 0.0142 0.5
Schistosoma mansoni hypothetical protein 0.0205 0.0381 0.038
Schistosoma mansoni tar DNA-binding protein 0.0069 0.011 0.0109
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0043 0.0056
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0381 0.038
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0043 0.0056
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.011 0.011
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0323 0.0619 0.0611
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0111 0.011
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0032 0.0031
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0142 0.019
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0323 0.0619 0.0618
Loa Loa (eye worm) phosphatidylinositol 3 0.168 0.3335 0.3335
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0023 0.0022
Loa Loa (eye worm) cysteine protease 0.0018 0.0008 0.0008
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0323 0.0619 0.0611
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5008 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0104 0.0181 0.018
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0323 0.0619 0.0619
Echinococcus granulosus cathepsin l1 0.0018 0.0008 0.0008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0044 0.0044
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0234 0.0233
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0008 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.168 0.3335 0.3334
Onchocerca volvulus 0.0029 0.0031 0.0476
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0015 0.0001 0.0001
Echinococcus multilocularis muscleblind protein 1 0.018 0.0333 0.0333
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0043 0.0056
Loa Loa (eye worm) hypothetical protein 0.005 0.0071 0.0071
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0058 0.0087 0.0087
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5008 1 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0008 0.0007
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0023 0.0022
Brugia malayi intermediate filament protein 0.0029 0.0031 0.0029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.168 0.3335 0.3334
Brugia malayi 6-phosphofructokinase 0.0131 0.0234 0.0233
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.3251 0.6482 0.6481
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0323 0.0619 0.0618
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0058 0.0087 0.0086
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0323 0.0619 0.0619
Schistosoma mansoni hypothetical protein 0.0323 0.0619 0.0618
Entamoeba histolytica hypothetical protein 0.0323 0.0619 0.0611
Entamoeba histolytica protein kinase rad3, putative 0.0947 0.1868 0.1862
Entamoeba histolytica hypothetical protein 0.0323 0.0619 0.0611
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0021 0.0014 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.2704 0.5387 0.5386
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.0234 0.3778
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0323 0.0619 0.0618
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0947 0.1868 0.1867
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0007
Entamoeba histolytica protein kinase, putative 0.0034 0.0039 0.0031
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0234 0.0233
Echinococcus multilocularis muscleblind protein 0.018 0.0333 0.0333
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2369 0.4714 0.4714
Brugia malayi hypothetical protein 0.002 0.0011 0.001
Schistosoma mansoni voltage-gated potassium channel 0.0122 0.0216 0.0215
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0323 0.0619 0.0618
Trichomonas vaginalis fk506-binding protein, putative 0.0058 0.0087 0.0086
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3988 0.7956 0.7956
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0018 0.0017
Echinococcus granulosus cGMP dependent protein kinase 0.0015 0.0002 0.0002
Giardia lamblia Hypothetical protein 0.0323 0.0619 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0947 0.1868 0.1867
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0947 0.1868 0.1868
Loa Loa (eye worm) phosphatidylinositol kinase 0.0323 0.0619 0.0619
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0596 0.0595
Brugia malayi phosphofructokinase 0.0131 0.0234 0.0233
Entamoeba histolytica protein kinase 2, putative 0.0021 0.0014 0.0006
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0323 0.0619 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.168 0.3335 0.3334
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0028 0.0027
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0015 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.3984 0.7948 0.7948
Echinococcus multilocularis cysteine protease 0.0018 0.0008 0.0008
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0008 0.0114
Schistosoma mansoni ran 0.0026 0.0023 0.0022
Leishmania major phosphatidylinositol 3-related kinase, putative 0.168 0.3335 0.3334
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0007
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0022 0.0016 0.0016
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.168 0.3335 0.3334
Loa Loa (eye worm) phosphatidylinositol 3 0.0323 0.0619 0.0619
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0323 0.0619 0.0618
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0041 0.0041
Loa Loa (eye worm) phosphofructokinase 0.0131 0.0234 0.0234
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0323 0.0619 0.0618
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0323 0.0619 0.0618
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0036 0.0035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0044 0.0043
Mycobacterium tuberculosis Conserved hypothetical protein 0.0323 0.0619 1
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0058 0.0087 0.0086
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.168 0.3335 0.3334
Brugia malayi Cathepsin L-like precursor 0.0018 0.0008 0.0007
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0016 0.0015
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0323 0.0619 0.0618
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0323 0.0619 0.0619
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.0234 0.0234
Onchocerca volvulus 0.0029 0.0031 0.0476
Leishmania major cathepsin L-like protease 0.007 0.0111 0.011
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.0234 0.0234
Leishmania major cathepsin L-like protease 0.0018 0.0008 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.1055 0.2085 0.2084
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0023 0.0352
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0044 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0403 0.0402
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0043 0.2931
Leishmania major hypothetical protein, unknown function 0.0323 0.0619 0.0618
Echinococcus granulosus hyperpolarization activated cyclic 0.0022 0.0016 0.0016
Toxoplasma gondii target of rapamycin (TOR), putative 0.3725 0.743 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.0234 1
Onchocerca volvulus 0.0323 0.0619 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0032 0.0508
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0008 0.0008
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0323 0.0619 0.0619
Trichomonas vaginalis PIKK family atypical protein kinase 0.3725 0.743 0.743
Toxoplasma gondii hypothetical protein 0.0029 0.003 0.0039
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0323 0.0619 0.0618
Schistosoma mansoni ran 0.0026 0.0023 0.0022
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0323 0.0619 0.0618
Entamoeba histolytica hypothetical protein 0.0039 0.005 0.0042
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0039 0.0038
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0323 0.0619 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.336 0.6698 0.6698
Trichomonas vaginalis PIKK family atypical protein kinase 0.3725 0.743 0.743
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0323 0.0619 0.0831
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0323 0.0619 0.0831
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0323 0.0619 0.0831
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.0018 0.0017
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0947 0.1868 0.1867
Echinococcus multilocularis nervana 2 0.0021 0.0013 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0111 0.011
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0112 0.0195 0.0194
Loa Loa (eye worm) hypothetical protein 0.1055 0.2085 0.2085
Echinococcus granulosus microtubule associated protein 2 0.0753 0.148 0.148
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0022 0.0016 0.0016
Giardia lamblia GTOR 0.5008 1 1
Onchocerca volvulus 0.0018 0.0008 0.0114
Brugia malayi p70 ribosomal S6 kinase beta 0.0032 0.0035 0.0034
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0008 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0111 0.011
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0323 0.0619 0.0618
Onchocerca volvulus 0.0018 0.0008 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.3984 0.7948 0.7948
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0323 0.0619 0.0618
Trypanosoma brucei rac serine-threonine kinase, putative 0.0034 0.0039 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0111 0.011
Schistosoma mansoni intermediate filament proteins 0.0029 0.0031 0.0029
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0596 0.0595
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0323 0.0619 1
Loa Loa (eye worm) hypothetical protein 0.018 0.0333 0.0333
Onchocerca volvulus 0.0018 0.0008 0.0114
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0323 0.0619 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0947 0.1868 0.1867
Schistosoma mansoni immunophilin 0.0058 0.0087 0.0086
Echinococcus multilocularis tar DNA binding protein 0.0069 0.011 0.011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0008 0.0007
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0323 0.0619 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0947 0.1868 0.1867
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0323 0.0619 0.0619
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0016 0.0015
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0039 0.0038
Echinococcus granulosus nervana 2 0.0021 0.0013 0.0013
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0016 0.0015
Echinococcus multilocularis lamin 0.0029 0.0031 0.0031
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0015 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0732 0.1438 0.1437
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0084 0.1336
Onchocerca volvulus 0.0036 0.0044 0.069
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0008 0.0114
Onchocerca volvulus 0.0018 0.0008 0.0114
Brugia malayi RNA binding protein 0.0069 0.011 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0044 0.0043
Loa Loa (eye worm) hypothetical protein 0.0032 0.0036 0.0036
Plasmodium vivax hypothetical protein, conserved 0.0323 0.0619 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0007
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0234 0.0233
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0008 0.0007
Leishmania major cathepsin L-like protease 0.007 0.0111 0.011
Brugia malayi Cyclic-nucleotide gated cation channel 0.0022 0.0016 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0008 0.0007

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.6746 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 2.8184 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (binding) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.8876 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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