Detailed information for compound 1645000

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 481.288 | Formula: C23H14Cl2N4O4
  • H donors: 0 H acceptors: 2 LogP: 4.59 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)Oc1c(Cl)cnn(c1=O)C1=Nc2cc(Cl)ccc2Oc2c1cccn2
  • InChi: 1S/C23H14Cl2N4O4/c1-31-14-5-7-15(8-6-14)32-20-17(25)12-27-29(23(20)30)21-16-3-2-10-26-22(16)33-19-9-4-13(24)11-18(19)28-21/h2-12H,1H3
  • InChiKey: ITIHNZAIVSYCNW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptides B/W receptor 1 Starlite/ChEMBL References
Homo sapiens melanin-concentrating hormone receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis growth hormone secretagogue receptor type 1 neuropeptides B/W receptor 1 328 aa 296 aa 21.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.001 0.0009
Echinococcus granulosus solute carrier family 22 0.0016 0.0005 0.0004
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0225 0.058 0.0579
Trypanosoma cruzi target of rapamycin kinase 3 0.2778 0.7596 0.7953
Loa Loa (eye worm) hypothetical protein 0.0078 0.0176 0.0184
Echinococcus multilocularis dna polymerase eta 0.0015 0.0004 0.0002
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0225 0.058 0.0606
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0006
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0025 0.007
Echinococcus granulosus expressed protein 0.0029 0.004 0.0039
Loa Loa (eye worm) transcription factor SMAD2 0.091 0.2462 0.2578
Toxoplasma gondii FATC domain-containing protein 0.066 0.1775 0.2497
Trichomonas vaginalis PIKK family atypical protein kinase 0.2085 0.5691 0.5958
Trichomonas vaginalis PIKK family atypical protein kinase 0.2775 0.7588 0.7945
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0015 0.0001 0.0001
Echinococcus granulosus dna polymerase kappa 0.0044 0.0081 0.008
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0225 0.058 0.0606
Echinococcus multilocularis voltage gated potassium channel 0.0021 0.002 0.0019
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0009 0.0025
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0026
Schistosoma mansoni fkbp-rapamycin associated protein 0.066 0.1775 0.1774
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0114 0.0274 0.0273
Echinococcus granulosus ferritin 0.0029 0.004 0.0039
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0225 0.058 0.0811
Loa Loa (eye worm) glutaminase 0.031 0.0814 0.0853
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0073 0.0163 0.0162
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0055 0.0113 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0081 0.0081
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.01 0.01
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.3489 0.955 0.955
Onchocerca volvulus 0.0277 0.0721 0.3202
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0059 0.0057
Mycobacterium leprae Probable lipase LipE 0.0078 0.0176 0.2773
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0031 0.0029
Plasmodium vivax hypothetical protein 0.0225 0.058 0.4474
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0176 0.0183
Schistosoma mansoni hypothetical protein 0.0136 0.0336 0.0334
Schistosoma mansoni ferritin light chain 0.0029 0.004 0.0039
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0106 0.0252 0.4129
Brugia malayi beta-lactamase family protein 0.0078 0.0176 0.0183
Loa Loa (eye worm) MH2 domain-containing protein 0.091 0.2462 0.2578
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0026
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.0386 0.2879
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0142 0.0351 0.0349
Echinococcus multilocularis tumor protein p63 0.1069 0.2901 0.29
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.066 0.1775 0.1857
Loa Loa (eye worm) phosphatidylinositol 3 0.0225 0.058 0.0607
Toxoplasma gondii hypothetical protein 0.0047 0.0091 0.0121
Plasmodium vivax SET domain protein, putative 0.0035 0.0057 0.0403
Brugia malayi FAT domain containing protein 0.051 0.1364 0.1427
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.001 0.0009
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0161 0.0404 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0056 0.0114 0.0845
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0225 0.058 0.0604
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0225 0.058 0.0604
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0006
Trichomonas vaginalis sugar transport protein, putative 0.0016 0.0005 0.0004
Schistosoma mansoni thyroid hormone receptor 0.0153 0.0382 0.0381
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.001 0.0009
Leishmania major hypothetical protein, conserved 0.0078 0.0176 0.018
Echinococcus multilocularis GPCR, family 2 0.0136 0.0336 0.0334
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.001 0.0009
Plasmodium falciparum calcium-dependent protein kinase 2 0.0035 0.0057 0.0404
Trichomonas vaginalis PIKK family atypical protein kinase 0.3489 0.955 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0176 0.0183
Onchocerca volvulus 0.083 0.2242 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0035 0.0057 0.0404
Trichomonas vaginalis PIKK family atypical protein kinase 0.117 0.3177 0.3326
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0676 0.182 0.1819
Onchocerca volvulus Cathepsin L homolog 0.0018 0.001 0.0022
Onchocerca volvulus 0.0018 0.001 0.0022
Echinococcus granulosus chromobox protein 1 0.0072 0.0159 0.0157
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0225 0.058 0.4474
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.001 0.0009
Leishmania major phosphatidylinositol 3-related kinase, putative 0.117 0.3177 0.3324
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.0075
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0006
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0161 0.0404 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0055 0.0113 0.0111
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0225 0.058 0.0604
Schistosoma mansoni hypothetical protein 0.0225 0.058 0.0579
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.004 0.004
Schistosoma mansoni Smad4 0.0028 0.0038 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.058 0.0606
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0016 0.0005 0.0002
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0225 0.058 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0435 0.1156 0.121
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.0274 0.0273
Loa Loa (eye worm) beta-lactamase 0.0078 0.0176 0.0184
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0081 0.0081
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0055 0.0113 0.0111
Loa Loa (eye worm) hypothetical protein 0.0033 0.0052 0.0055
Echinococcus granulosus tumor protein p63 0.1069 0.2901 0.29
Plasmodium vivax hypothetical protein, conserved 0.0078 0.0176 0.1327
Trichomonas vaginalis PIKK family atypical protein kinase 0.2265 0.6186 0.6477
Brugia malayi Cathepsin L-like precursor 0.0018 0.001 0.0009
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.001 0.0009
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.066 0.1775 0.1774
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0184 0.0189
Loa Loa (eye worm) hypothetical protein 0.0078 0.0176 0.0184
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0005 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0081 0.0081
Toxoplasma gondii protein kinase, putative 0.0322 0.0846 0.1186
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0021 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.2085 0.5691 0.5958
Loa Loa (eye worm) phosphatidylinositol 3 0.0225 0.058 0.0607
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0225 0.058 0.0606
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0071 0.007
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.0071 0.007
Loa Loa (eye worm) hypothetical protein 0.0225 0.058 0.0607
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.051 0.1364 0.1362
Echinococcus multilocularis tar DNA binding protein 0.0676 0.182 0.1819
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0028 0.0038 0.0144
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0006 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.066 0.1775 0.1857
Schistosoma mansoni sugar transporter 0.0016 0.0005 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.001 0.0009
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0184 0.1388
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0004 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.3489 0.955 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0225 0.058 0.0579
Entamoeba histolytica hypothetical protein 0.0225 0.058 0.0604
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0136 0.0336 0.0334
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0225 0.058 0.0579
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0005 0.0004
Echinococcus multilocularis Smad4 0.0062 0.0132 0.013
Leishmania major phosphatidylinositol 3-kinase, putative 0.0225 0.058 0.0604
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0031 0.0188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0148 0.0151
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0005 0.0004
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0225 0.058 0.0604
Schistosoma mansoni smad 0.0028 0.0038 0.0036
Schistosoma mansoni protein kinase 0.0035 0.0057 0.0056
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0161 0.0404 0.3105
Plasmodium falciparum mitogen-activated protein kinase 2 0.0184 0.0467 0.3595
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.2775 0.7588 0.7945
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0052 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0148 0.0151
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0006
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0059 0.006
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Entamoeba histolytica hypothetical protein 0.0225 0.058 0.0604
Brugia malayi MH2 domain containing protein 0.0062 0.0132 0.0137
Echinococcus multilocularis smad 0.0062 0.0132 0.013
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0062 0.0132 0.013
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.001 0.0009
Giardia lamblia GTOR 0.3489 0.955 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0108 0.0109
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0009
Onchocerca volvulus 0.0225 0.058 0.2569
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.0176 0.0183
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.0176 0.1297
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.001 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0025 0.0024
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0114 0.0274 0.0273
Mycobacterium ulcerans beta-lactamase 0.0078 0.0176 0.2108
Brugia malayi MH2 domain containing protein 0.0062 0.0132 0.0137
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0005 0.0006
Trichomonas vaginalis DNA polymerase eta, putative 0.0044 0.0081 0.0084
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0005 0.0006
Loa Loa (eye worm) phosphatidylinositol 3 0.0225 0.058 0.0607
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0004 0.0002
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0114 0.0274 0.0273
Entamoeba histolytica hypothetical protein 0.0074 0.0165 0.0169
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Echinococcus multilocularis fk506 binding protein 0.0055 0.0113 0.0111
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0044 0.0081 0.0084
Trypanosoma brucei glucose transporter, putative 0.0035 0.0059 0.0057
Brugia malayi hypothetical protein 0.083 0.2242 0.2346
Schistosoma mansoni voltage-gated potassium channel 0.008 0.0182 0.018
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.066 0.1775 0.1855
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0055 0.0113 0.1981
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0004 0.0002
Leishmania major cathepsin L-like protease 0.0018 0.001 0.0007
Plasmodium vivax vivapain-2 0.0018 0.001 0.0038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0006 0.0019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.001 0.0009
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0031 0.0201
Toxoplasma gondii hypothetical protein 0.0056 0.0114 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.001 0.0006
Trichomonas vaginalis glutaminase, putative 0.031 0.0814 0.0851
Echinococcus multilocularis mothers against decapentaplegic 2 0.0028 0.0038 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.1881 0.5131 0.5372
Trichomonas vaginalis PIKK family atypical protein kinase 0.2595 0.7093 0.7427
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0071 0.007
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0029 0.004 0.0277
Trichomonas vaginalis PIKK family atypical protein kinase 0.1884 0.5139 0.538
Trypanosoma brucei sugar transporter, putative 0.0016 0.0005 0.0002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.001 0.0009
Echinococcus multilocularis peptidase Clp (S14 family) 0.0106 0.0252 0.025
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0057 0.0056
Loa Loa (eye worm) hypothetical protein 0.0078 0.0176 0.0184
Trypanosoma brucei PAB1-binding protein , putative 0.0081 0.0184 0.0189
Leishmania major glucose transporter/membrane transporter D2, putative 0.0035 0.0059 0.0057
Echinococcus multilocularis chromobox protein 1 0.0072 0.0159 0.0157
Echinococcus granulosus mothers against decapentaplegic 6 0.0028 0.0038 0.0036
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0055 0.0113 0.0114
Schistosoma mansoni sugar transporter 0.0016 0.0005 0.0004
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.066 0.1775 0.1857
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.3489 0.955 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.117 0.3177 0.3324
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0059 0.006
Mycobacterium ulcerans glutaminase 0.031 0.0814 1
Plasmodium falciparum protein kinase 7 0.0322 0.0846 0.6542
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0064 0.0137 0.0143
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0031 0.032
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0055 0.0113 0.1324
Echinococcus multilocularis expressed protein 0.0029 0.004 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.001 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.1881 0.5131 0.5372
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.001 0.0009
Leishmania major hypothetical protein, conserved 0.0225 0.058 0.0604
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.001 0.0009
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.3489 0.955 0.955
Loa Loa (eye worm) MH2 domain-containing protein 0.0062 0.0132 0.0138
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0225 0.058 0.0606
Schistosoma mansoni thyroid hormone receptor 0.0153 0.0382 0.0381
Brugia malayi hypothetical protein 0.0074 0.0165 0.0172
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.0071 0.007
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.0176 0.0175
Loa Loa (eye worm) hypothetical protein 0.0081 0.0184 0.0192
Toxoplasma gondii facilitative glucose transporter GT1 0.0114 0.0274 0.038
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0021 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.005
Schistosoma mansoni hypothetical protein 0.0074 0.0165 0.0164
Brugia malayi hypothetical protein 0.0052 0.0105 0.0108
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0025 0.0238
Loa Loa (eye worm) sugar transporter 0.0114 0.0274 0.0287
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0225 0.058 0.0579
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0055 0.0113 0.0116
Trypanosoma brucei glucose transporter 2A 0.0035 0.0059 0.0057
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0025 0.0022
Brugia malayi Cathepsin L-like precursor 0.0018 0.001 0.0009
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0061 0.006
Echinococcus granulosus TGF beta signal transducer SmadC 0.0062 0.0132 0.013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0006
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0343 0.0355
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0165 0.0164
Schistosoma mansoni sugar transporter 0.0016 0.0005 0.0004
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0225 0.058 0.0604
Trypanosoma brucei glucose transporter, putative 0.0035 0.0059 0.0057
Leishmania major cysteine peptidase A (CPA) 0.0018 0.001 0.0007
Trypanosoma brucei glucose transporter, putative 0.0035 0.0059 0.0057
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0176 0.0183
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0225 0.058 0.0604
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.008 0.0335
Loa Loa (eye worm) phosphatidylinositol 3 0.117 0.3177 0.3327
Echinococcus multilocularis thyroid hormone receptor alpha 0.0153 0.0382 0.0381
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0006
Echinococcus granulosus dna polymerase eta 0.0015 0.0004 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.001 0.0009
Brugia malayi Calcitonin receptor-like protein seb-1 0.043 0.1144 0.1197
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0225 0.058 0.0606
Brugia malayi chromobox protein homolog 3 0.004 0.0072 0.0074
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0148 0.0151
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.3489 0.955 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0005 0.0004
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.0767 0.08
Loa Loa (eye worm) hypothetical protein 0.0047 0.0092 0.0096
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0159 0.0165
Trypanosoma brucei target of rapamycin kinase 3, putative 0.2778 0.7596 0.7953
Loa Loa (eye worm) hypothetical protein 0.051 0.1364 0.1428
Plasmodium vivax vivapain-2 0.0018 0.001 0.0038
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0225 0.058 0.0579
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0055 0.0113 0.0114
Loa Loa (eye worm) hypothetical protein 0.0034 0.0055 0.0058
Trichomonas vaginalis glucose transporter, putative 0.0016 0.0005 0.0004
Onchocerca volvulus 0.0078 0.0176 0.0762
Loa Loa (eye worm) Smad1 0.0062 0.0132 0.0138
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.001 0.0007
Schistosoma mansoni ferritin 0.0029 0.004 0.0039
Loa Loa (eye worm) sugar transporter 0.0016 0.0005 0.0006
Entamoeba histolytica protein kinase, putative 0.0035 0.0057 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0005 0.0004
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.001 0.0009
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0073 0.0163 0.017
Trypanosoma brucei glucose transporter, putative 0.0035 0.0059 0.0057
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0159 0.0166
Giardia lamblia Phosphatidylinositol 4-kinase 0.0225 0.058 0.0602
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0055 0.0113 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0435 0.1156 0.1211
Loa Loa (eye worm) MH1 domain-containing protein 0.0062 0.0132 0.0138
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.3489 0.955 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Echinococcus granulosus mothers against decapentaplegic 2 0.0028 0.0038 0.0036
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0059 0.0057
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0136 0.0336 0.0334
Leishmania major hypothetical protein, unknown function 0.0225 0.058 0.0604
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0072 0.0298
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0225 0.058 0.0579
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0225 0.058 0.0606
Leishmania major glucose transporter, lmgt2 0.0035 0.0059 0.0057
Schistosoma mansoni smad 0.0062 0.0132 0.013
Schistosoma mansoni immunophilin 0.0055 0.0113 0.0111
Giardia lamblia DINP protein human, muc B family 0.0022 0.0023 0.0018
Echinococcus granulosus peptidase Clp S14 family 0.0106 0.0252 0.025
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.0629 0.0659
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0176 0.018
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0225 0.058 0.4474
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0034 0.0055 0.0057
Plasmodium vivax calcium-dependent protein kinase, putative 0.0035 0.0057 0.0404
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.001 0.0009
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0225 0.058 0.4474
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Leishmania major phosphatidylinositol kinase related protein, putative 0.0225 0.058 0.0604
Echinococcus granulosus chromobox protein 1 0.0072 0.0159 0.0157
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0161 0.0404 0.4932
Trichomonas vaginalis chromobox protein, putative 0.0043 0.008 0.0083
Echinococcus granulosus solute carrier family 22 0.0016 0.0005 0.0004
Echinococcus granulosus calcium dependent protein kinase 0.0033 0.0051 0.005
Brugia malayi Cathepsin L-like precursor 0.0018 0.001 0.0009
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0225 0.058 0.0604
Loa Loa (eye worm) fibroinase 0.0018 0.001 0.0011
Schistosoma mansoni apoferritin-2 0.0029 0.004 0.0039
Leishmania major myo-inositol/proton symporter (MIT) 0.0016 0.0005 0.0002
Loa Loa (eye worm) MH1 domain-containing protein 0.0028 0.0038 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.234 0.6393 0.6694
Schistosoma mansoni immunophilin 0.0055 0.0113 0.0111
Onchocerca volvulus 0.0018 0.001 0.0022
Trypanosoma brucei glucose transporter, putative 0.0035 0.0059 0.0057
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.3489 0.955 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0075 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0148 0.0151
Mycobacterium leprae conserved hypothetical protein 0.0078 0.0176 0.2773
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.051 0.1364 0.1362
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0034 0.0055 0.0618
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Schistosoma mansoni ferritin 0.0029 0.004 0.0039
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0136 0.0336 0.0334
Mycobacterium ulcerans hypothetical protein 0.0078 0.0176 0.2108
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.002 0.0019
Leishmania major cathepsin L-like protease 0.0068 0.0148 0.0151
Onchocerca volvulus 0.0225 0.058 0.2569
Echinococcus multilocularis microtubule associated protein 2 0.3652 1 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.0336 0.0352
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0081 0.0081
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0225 0.058 0.4474
Echinococcus multilocularis mothers against decapentaplegic 6 0.0028 0.0038 0.0036
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0184 0.0467 0.0651
Brugia malayi hypothetical protein 0.0016 0.0005 0.0004
Plasmodium vivax ataxin-2 like protein, putative 0.0081 0.0184 0.1388
Leishmania major cathepsin L-like protease 0.0018 0.001 0.0007
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0009 0.0025
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0225 0.058 0.0579
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0148 0.0151
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0081 0.0081
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0009 0.004
Schistosoma mansoni hypothetical protein 0.0136 0.0336 0.0334
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0057 0.0056
Entamoeba histolytica protein kinase, putative 0.0035 0.0057 0.0056
Plasmodium vivax proline--tRNA ligase, putative 0.004 0.0071 0.051
Echinococcus multilocularis solute carrier family 22 0.0016 0.0005 0.0004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.066 0.1775 0.1857
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.001 0.0009
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0225 0.058 0.0579
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0225 0.058 0.0604
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.2778 0.7596 0.7953
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0057 0.0056
Loa Loa (eye worm) RNA binding protein 0.0676 0.182 0.1906
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.0176 0.1297
Loa Loa (eye worm) cysteine protease 0.0018 0.001 0.0011
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0029 0.004 0.0878
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.0176 0.1297
Brugia malayi hypothetical protein 0.0016 0.0005 0.0004
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.0176 0.0184
Echinococcus multilocularis solute carrier family 22 0.0016 0.0005 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0072 0.0074
Brugia malayi Smad1 0.0062 0.0132 0.0137
Echinococcus granulosus solute carrier family 22 0.0016 0.0005 0.0004
Entamoeba histolytica hypothetical protein 0.0225 0.058 0.0604
Loa Loa (eye worm) FKBP5 protein 0.0055 0.0113 0.0118
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0047 0.009 0.0088
Trypanosoma cruzi hexose transporter 0.0035 0.0059 0.0057
Leishmania major hypothetical protein, conserved 0.0081 0.0184 0.0189
Echinococcus multilocularis dna polymerase kappa 0.0044 0.0081 0.008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0006
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0025 0.0238
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0225 0.058 0.0602
Onchocerca volvulus 0.0078 0.0176 0.0762
Brugia malayi Sugar transporter family protein 0.0016 0.0005 0.0004
Leishmania major hypothetical protein, conserved 0.0016 0.0005 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0176 0.0183
Echinococcus multilocularis calcium dependent protein kinase 0.0033 0.0051 0.005
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0131 0.0134
Leishmania major phosphatidylinositol 4-kinase, putative 0.0225 0.058 0.0604
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0022 0.0021 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.004 0.004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0225 0.058 0.0606
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0031 0.032
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0176 0.018
Trichomonas vaginalis PIKK family atypical protein kinase 0.3489 0.955 1
Schistosoma mansoni ferritin 0.0029 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0006
Entamoeba histolytica protein kinase rad3, putative 0.066 0.1775 0.1855
Echinococcus granulosus smad 0.0062 0.0132 0.013
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.066 0.1775 0.1774
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.0033
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0034 0.0055 0.0057
Echinococcus multilocularis cysteine protease 0.0018 0.001 0.0009
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0225 0.058 0.0604
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0081 0.0081
Leishmania major phosphatidylinositol kinase, putative 0.0225 0.058 0.0604
Schistosoma mansoni hypothetical protein 0.0136 0.0336 0.0334
Brugia malayi hypothetical protein 0.0081 0.0184 0.0191
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0055 0.0113 0.0116
Trypanosoma brucei unspecified product 0.0037 0.0062 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0081 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.2595 0.7093 0.7427
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.001 0.0009
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0161 0.0404 0.4932
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0055 0.0113 0.0116
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0035 0.0057 0.0073
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0225 0.058 0.0604
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0343 0.0355
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Toxoplasma gondii LsmAD domain-containing protein 0.0081 0.0184 0.0251
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0057 0.0056
Schistosoma mansoni Smad4 0.0062 0.0132 0.013
Loa Loa (eye worm) hypothetical protein 0.0225 0.058 0.0607
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0035 0.0057 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0225 0.058 0.0606
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0025 0.0238
Trichomonas vaginalis immunophilin, putative 0.0055 0.0113 0.0116
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0057 0.0059
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.001 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0025 0.0024
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0057 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.001 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0005 0.0004
Leishmania major cathepsin L-like protease 0.0018 0.001 0.0007
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0225 0.058 0.0604
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.0176 0.1297
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0005 0.0002
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.001 0.0038
Brugia malayi Heterochromatin protein 1 0.0072 0.0159 0.0165
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0057 0.0056
Brugia malayi Cathepsin L-like precursor 0.0018 0.001 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0936 0.2534 0.2652
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0034 0.0055 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.1884 0.5139 0.538
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.001 0.0009
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0225 0.058 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.2064 0.5634 0.5899
Schistosoma mansoni hypothetical protein 0.0136 0.0336 0.0334
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0031 0.003
Mycobacterium leprae conserved hypothetical protein 0.0225 0.058 1
Schistosoma mansoni hypothetical protein 0.0114 0.0274 0.0273
Loa Loa (eye worm) hypothetical protein 0.0035 0.0057 0.006
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.117 0.3177 0.3326
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0676 0.182 0.1906
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0021 0.002 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.2595 0.7093 0.7427
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0023 0.0022
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0035 0.0057 0.0056
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.066 0.1775 0.1855
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0148 0.0151
Mycobacterium ulcerans lipase LipD 0.0078 0.0176 0.2108
Schistosoma mansoni smad1 5 8 and 0.0062 0.0132 0.013
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0054 0.0052
Schistosoma mansoni Smad4 0.0028 0.0038 0.0036
Schistosoma mansoni voltage-gated potassium channel 0.008 0.0182 0.018
Trichomonas vaginalis chromobox protein, putative 0.0043 0.008 0.0083
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.0176 0.1297
Echinococcus granulosus tar DNA binding protein 0.0676 0.182 0.1819
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0025 0.0022
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0073 0.0163 0.0171
Trypanosoma brucei glucose transporter, putative 0.0035 0.0059 0.0057
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.001 0.0011
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.0274 0.0273
Brugia malayi major facilitator superfamily protein 0.0016 0.0005 0.0004
Schistosoma mansoni ferritin light chain 0.0029 0.004 0.0039
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0006 0.0019
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0035 0.0057 0.0073
Leishmania major cathepsin L-like protease 0.0068 0.0148 0.0151
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0031 0.003
Echinococcus granulosus voltage gated potassium channel 0.0021 0.002 0.0019
Echinococcus multilocularis chromobox protein 1 0.0072 0.0159 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0072 0.0074
Brugia malayi polk-prov protein 0.0033 0.0052 0.0053
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.3489 0.955 1
Schistosoma mansoni glutaminase 0.031 0.0814 0.0813
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.117 0.3177 0.3176
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0073 0.0163 0.0162
Brugia malayi MH1 domain containing protein 0.0034 0.0056 0.0057
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0034 0.0055 0.0054
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0225 0.058 0.0606
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0225 0.058 0.0579
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0025 0.0022
Onchocerca volvulus 0.0078 0.0176 0.0762
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0025 0.0238
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.001 0.0009
Loa Loa (eye worm) glutaminase 2 0.031 0.0814 0.0853
Plasmodium falciparum calcium-dependent protein kinase 4 0.0035 0.0057 0.0404
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0148 0.0151
Entamoeba histolytica hypothetical protein 0.0074 0.0165 0.0169
Echinococcus granulosus solute carrier family 22 0.0016 0.0005 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0148 0.0151
Loa Loa (eye worm) hypothetical protein 0.0034 0.0055 0.0058
Onchocerca volvulus 0.0018 0.001 0.0022
Echinococcus multilocularis mothers against decapentaplegic 5 0.0062 0.0132 0.013
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0055 0.0113 0.0114
Echinococcus granulosus serine:threonine protein kinase SMG1 0.066 0.1775 0.1774
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0035 0.0057 0.006
Schistosoma mansoni hypothetical protein 0.0142 0.0351 0.0349
Mycobacterium tuberculosis Conserved hypothetical protein 0.0225 0.058 0.4341
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0081 0.0081
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.117 0.3177 0.3324
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0343 0.0355
Loa Loa (eye worm) hypothetical protein 0.0078 0.0176 0.0184
Mycobacterium ulcerans bacterioferritin BfrA 0.0029 0.004 0.0433
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0159 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.2085 0.5691 0.5958
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0059 0.006
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0106 0.0252 0.1868
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.001 0.0009
Trypanosoma cruzi glucose transporter, putative 0.0016 0.0005 0.0002
Onchocerca volvulus Cathepsin L homolog 0.0018 0.001 0.0022
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0005 0.0004
Mycobacterium ulcerans bacterioferritin BfrB 0.0029 0.004 0.0433
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0081 0.0081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.066 0.1775 0.1859
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0057 0.0056
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.0176 0.2108
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0055 0.0054
Trichomonas vaginalis myo-inositol transporter, putative 0.0016 0.0005 0.0004
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0055 0.0113 0.0118
Loa Loa (eye worm) hypothetical protein 0.0034 0.0056 0.0058
Entamoeba histolytica cysteine protease, putative 0.0018 0.001 0.0007
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0225 0.058 0.0607
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0225 0.058 0.0579
Schistosoma mansoni apoferritin-2 0.0029 0.004 0.0039
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0055 0.0113 0.0112
Entamoeba histolytica hypothetical protein 0.0025 0.0031 0.0029
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0035 0.0057 0.0056
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0114 0.0274 0.0273
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.165 0.4496 0.4706
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0031 0.0031
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0021 0.002 0.0019
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0057 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0735 0.1982 0.2074
Loa Loa (eye worm) phosphatidylinositol 3 0.0225 0.058 0.0607
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0004 0.0002
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0057 0.0056
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0006
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0035 0.0057 0.0404
Brugia malayi beta-lactamase family protein 0.0078 0.0176 0.0183
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0161 0.0404 0.0563
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.001 0.0009
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.001 0.0007
Loa Loa (eye worm) TAR-binding protein 0.0676 0.182 0.1906
Mycobacterium tuberculosis Conserved protein 0.0078 0.0176 0.1297
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0025 0.0022
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0225 0.058 0.0811
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0136 0.0336 0.0334
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0006
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Echinococcus multilocularis serine protein kinase ATM 0.066 0.1775 0.1774
Onchocerca volvulus 0.0032 0.0048 0.0191
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0021
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0081 0.0937
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0225 0.058 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.1884 0.5139 0.538
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0005 0.0004
Entamoeba histolytica hypothetical protein 0.066 0.1775 0.1855
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0004 0.0002
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.001 0.0011
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0031 0.0027
Echinococcus multilocularis solute carrier family 22 0.0016 0.0005 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.2064 0.5634 0.5899
Trichomonas vaginalis PIKK family atypical protein kinase 0.2595 0.7093 0.7427
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0004 0.0002
Schistosoma mansoni ferritin 0.0029 0.004 0.0039
Trichomonas vaginalis fk506-binding protein, putative 0.0055 0.0113 0.0116
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.066 0.1775 0.1855
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0435 0.1156 0.1207
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0225 0.058 0.4474
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0225 0.058 0.0604
Leishmania major cathepsin L-like protease 0.0068 0.0148 0.0151
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0161 0.0404 0.0563
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.3489 0.955 0.955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0225 0.058 0.0604
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0034 0.0055 0.0054
Schistosoma mansoni tar DNA-binding protein 0.0676 0.182 0.1819
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0148 0.0151
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0184 0.1388
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.015 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.001 0.0009
Leishmania major protein kinase, putative 0.0035 0.0057 0.0056
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0165 0.0164
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.0176 0.1297
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0225 0.058 0.0579
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0006
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.058 0.0606
Schistosoma mansoni hypothetical protein 0.051 0.1364 0.1362
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0176 0.0183
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0031 0.003
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0225 0.058 0.0811
Trichomonas vaginalis conserved hypothetical protein 0.0435 0.1156 0.121
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0142 0.0351 0.0349
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.3489 0.955 1
Leishmania major glucose transporter, lmgt3 0.0035 0.0059 0.0057
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.001 0.0038
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0057 0.0056
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.0274 0.0273
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.001 0.0007
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0055 0.0113 0.0834
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0031 0.0031
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0035 0.0057 0.0073
Schistosoma mansoni hypothetical protein 0.0036 0.0061 0.006
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0225 0.058 0.0811
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0009
Loa Loa (eye worm) phosphatidylinositol 3 0.3489 0.955 1
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0056 0.0114 0.1667
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0225 0.058 0.0606
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0006
Toxoplasma gondii ABC1 family protein 0.0078 0.0176 0.024
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0148 0.0151
Echinococcus multilocularis ferritin 0.0029 0.004 0.0039
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0025 0.007
Plasmodium vivax hexose transporter 0.0114 0.0274 0.2094
Schistosoma mansoni glucose transport protein 0.0114 0.0274 0.0273
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0225 0.058 0.0606
Brugia malayi glutaminase DH11.1 0.031 0.0814 0.0851
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0081 0.0937
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.3489 0.955 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0035 0.0057 0.006
Brugia malayi major facilitator superfamily protein 0.0016 0.0005 0.0004
Brugia malayi TAR-binding protein 0.0676 0.182 0.1904
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0225 0.058 0.0606
Leishmania major DNA polymerase kappa, putative 0.0022 0.0023 0.002
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0055 0.0113 0.0114
Loa Loa (eye worm) hypothetical protein 0.0078 0.0176 0.0184
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.001 0.0006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0136 0.0336 0.035
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0056 0.0114 0.2021
Loa Loa (eye worm) latrophilin receptor protein 2 0.0136 0.0336 0.0352
Plasmodium vivax hypothetical protein, conserved 0.0225 0.058 0.4474
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0148 0.0151
Schistosoma mansoni glucose transport protein 0.0114 0.0274 0.0273
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0225 0.058 0.0606
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0031 0.0571
Schistosoma mansoni chromobox protein 0.0072 0.0159 0.0157
Echinococcus granulosus General substrate transporter 0.0098 0.023 0.0229
Echinococcus granulosus GPCR family 2 0.0136 0.0336 0.0334
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0225 0.058 0.0579
Loa Loa (eye worm) hypothetical protein 0.0078 0.0176 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0059 0.006
Mycobacterium ulcerans hypothetical protein 0.0154 0.0386 0.4705
Schistosoma mansoni microtubule-associated protein tau 0.3652 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0057 0.0056
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0161 0.0404 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0225 0.058 0.0606
Trypanosoma brucei glucose transporter 1E 0.0035 0.0059 0.0057
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0225 0.058 0.0606
Trichomonas vaginalis set domain proteins, putative 0.0277 0.0721 0.0754
Trichomonas vaginalis PIKK family atypical protein kinase 0.117 0.3177 0.3326
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0047 0.0092 0.009
Brugia malayi Cathepsin L-like precursor 0.0018 0.001 0.0009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0006 0.0019
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0059 0.0057
Loa Loa (eye worm) hypothetical protein 0.0157 0.0392 0.041
Trichomonas vaginalis PIKK family atypical protein kinase 0.066 0.1775 0.1857
Brugia malayi Sugar transporter family protein 0.0016 0.0005 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0023 0.002
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.117 0.3177 0.3324
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0225 0.058 0.0604
Schistosoma mansoni smad1 5 8 and 0.0062 0.0132 0.013
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0225 0.058 0.0604
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0225 0.058 0.0604
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0735 0.1982 0.2789
Onchocerca volvulus 0.0023 0.0025 0.0086
Brugia malayi Pre-SET motif family protein 0.0035 0.0057 0.0058
Trypanosoma cruzi sugar transporter, putative 0.0016 0.0005 0.0002
Brugia malayi Pre-SET motif family protein 0.0243 0.0629 0.0658
Schistosoma mansoni cellular tumor antigen P53 0.0157 0.0392 0.039
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0034 0.0055 0.0054
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0056 0.0114 0.0845
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0009
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0106 0.0252 0.1868
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0009 0.0038
Plasmodium falciparum proline--tRNA ligase 0.004 0.0071 0.051
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0035 0.0057 0.0404
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0176 0.0175
Onchocerca volvulus 0.0018 0.001 0.0022
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0023 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.001 0.0006
Brugia malayi MH2 domain containing protein 0.0028 0.0038 0.0038
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0148 0.0151
Echinococcus multilocularis 0.0225 0.058 0.0579
Echinococcus granulosus Smad4 0.0062 0.0132 0.013
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.066 0.1775 0.1855
Schistosoma mansoni glucose transporter 0.0016 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0161 0.0404 0.0423
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0225 0.058 0.0604
Loa Loa (eye worm) ctsf protein 0.0018 0.001 0.0011
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0711 0.1916 0.2006
Trichomonas vaginalis PIKK family atypical protein kinase 0.1884 0.5139 0.538
Echinococcus granulosus cathepsin l1 0.0018 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.083 0.2242 0.2348
Echinococcus multilocularis solute carrier family 22 0.0016 0.0005 0.0004
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0225 0.058 0.0811
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0061 0.006
Brugia malayi beta-lactamase 0.0078 0.0176 0.0183
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0225 0.058 0.0606
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.043 0.1144 0.1197
Schistosoma mansoni hypothetical protein 0.0294 0.077 0.0769
Trichomonas vaginalis PIKK family atypical protein kinase 0.1881 0.5131 0.5372
Echinococcus multilocularis cysteine protease 0.0018 0.001 0.0009
Schistosoma mansoni sugar transporter 0.0016 0.0005 0.0004
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0225 0.058 0.0604
Trichomonas vaginalis ferritin, putative 0.0029 0.004 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0148 0.0151
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0057 0.0073
Brugia malayi Probable ClpP-like protease 0.0161 0.0404 0.0422
Mycobacterium tuberculosis Conserved protein 0.0078 0.0176 0.1297
Mycobacterium ulcerans hypothetical protein 0.0023 0.0025 0.0238
Onchocerca volvulus Cathepsin F homolog 0.0018 0.001 0.0022
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.3489 0.955 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0023 0.0145
Loa Loa (eye worm) hypothetical protein 0.0035 0.0057 0.006
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Schistosoma mansoni chromobox protein 0.0072 0.0159 0.0157
Brugia malayi Cathepsin L-like precursor 0.0018 0.001 0.0009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0176 0.0175
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0055 0.0113 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0052 0.0051
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.117 0.3177 0.3324
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.001 0.0009
Loa Loa (eye worm) phosphatidylinositol kinase 0.0225 0.058 0.0607
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0161 0.0404 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Schistosoma mansoni protein kinase 0.0035 0.0057 0.0056
Onchocerca volvulus 0.0018 0.001 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.2595 0.7093 0.7427
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0009
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0225 0.058 0.0606
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.117 0.3177 0.3176
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0161 0.0404 0.0403
Onchocerca volvulus 0.0047 0.009 0.0376
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.001 0.0009
Leishmania major fk506-binding protein 1-like protein 0.0055 0.0113 0.0114
Onchocerca volvulus 0.0018 0.001 0.0022
Schistosoma mansoni immunophilin 0.0047 0.0092 0.009
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0081 0.0081
Plasmodium falciparum protein kinase 6 0.0483 0.129 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.117 0.3177 0.3326
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.0767 0.08
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1449 0.3944 0.4128
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0059 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.117 0.3177 0.3326
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0055 0.0113 0.0111
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0025 0.0238
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0055 0.0054
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0057 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.2775 0.7588 0.7945
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0035 0.0057 0.0059
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0055 0.0113 0.0116
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0225 0.058 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.117 0.3177 0.3326
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.0176 0.1297
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0057 0.0056
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0081 0.0081
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.001 0.0009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.043 0.1144 0.1198
Loa Loa (eye worm) hypothetical protein 0.043 0.1144 0.1198
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0165 0.0164
Schistosoma mansoni smad1 5 8 and 0.0062 0.0132 0.013
Loa Loa (eye worm) MH2 domain-containing protein 0.0028 0.0038 0.0039
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0059 0.0057
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0025 0.0238
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0031 0.0029
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.015 0.0156
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0161 0.0404 0.6857
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.0767 0.08
Trichomonas vaginalis esterase, putative 0.0078 0.0176 0.0183
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.001 0.0009
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0081 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.2978 0.8148 0.8532
Giardia lamblia Prolyl-tRNA synthetase 0.0034 0.0055 0.0052
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0059 0.0057
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0161 0.0404 0.3105
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0225 0.058 0.0604
Schistosoma mansoni peptidase Clp (S14 family) 0.0161 0.0404 0.0403
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0039
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0225 0.058 0.0579
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0062 0.0061
Brugia malayi latrophilin 2 splice variant baaae 0.0294 0.077 0.0805
Leishmania major cathepsin L-like protease 0.0018 0.001 0.0007
Brugia malayi mothers against decapentaplegic homolog 3 0.0028 0.0038 0.0038
Giardia lamblia Hypothetical protein 0.0225 0.058 0.0602
Brugia malayi RNA binding protein 0.0676 0.182 0.1904
Schistosoma mansoni tar DNA-binding protein 0.0676 0.182 0.1819
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.001 0.0038
Toxoplasma gondii target of rapamycin (TOR), putative 0.2595 0.7093 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0225 0.058 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.2595 0.7093 0.7427
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0225 0.058 0.0579
Schistosoma mansoni DNA polymerase eta 0.0015 0.0004 0.0002
Echinococcus granulosus mothers against decapentaplegic 5 0.0062 0.0132 0.013
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0016 0.0005 0.0013
Brugia malayi MH1 domain containing protein 0.0062 0.0132 0.0137
Brugia malayi Cam kinase protein 1 0.0035 0.0057 0.0059
Loa Loa (eye worm) nuclear factor I 0.0034 0.0056 0.0058
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.3489 0.955 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0025 0.0158
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0015 0.0001 0.0001
Leishmania major cathepsin L-like protease 0.0018 0.001 0.0007
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0071 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.001 0.0009
Plasmodium falciparum hexose transporter 0.0114 0.0274 0.2094
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.117 0.3177 0.3324
Onchocerca volvulus 0.0157 0.0392 0.1727
Brugia malayi RNA recognition motif domain containing protein 0.0676 0.182 0.1904
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0081 0.0081
Echinococcus multilocularis Zinc finger, PHD finger 0.0225 0.058 0.0579
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0081 0.0081
Echinococcus granulosus serine protein kinase ATM 0.066 0.1775 0.1774
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0031 0.0029
Brugia malayi MH2 domain containing protein 0.091 0.2462 0.2577
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.0176 0.0175
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.004
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0031 0.0201
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0225 0.058 0.0604
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0031 0.003
Entamoeba histolytica hypothetical protein 0.0074 0.0165 0.0169
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0011
Schistosoma mansoni protein kinase 0.0035 0.0057 0.0056
Toxoplasma gondii cathepsin CPL 0.0018 0.001 0.0007
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.117 0.3177 0.3176
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0047 0.0092 0.009
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0184 0.0467 0.3595
Leishmania major peptidylprolyl isomerase-like protein 0.0055 0.0113 0.0114
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0225 0.058 0.0579
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0016 0.0005 0.0013
Brugia malayi Sugar transporter family protein 0.0114 0.0274 0.0286
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0225 0.058 0.4474
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0225 0.058 0.0579
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0055 0.0113 0.0834
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0055 0.0113 0.0111
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0225 0.058 0.0606
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.0767 0.08
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.0176 0.2108
Brugia malayi MH1 domain containing protein 0.0062 0.0132 0.0137
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0059 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.2775 0.7588 0.7945
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0225 0.058 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.2595 0.7093 0.7427
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0026
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0225 0.058 0.4474
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0161 0.0404 0.0403
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0225 0.058 0.0579
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0075 0.0074
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0029 0.004 0.0277
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0148 0.0151
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.004 0.0071 0.0092
Trypanosoma brucei glucose transporter, putative 0.0035 0.0059 0.0057
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0055 0.0113 0.0114
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0075 0.0074
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0025 0.0022
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0025 0.0022
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0225 0.058 0.0606
Plasmodium falciparum calcium-dependent protein kinase 3 0.0035 0.0057 0.0404
Brugia malayi Latrophilin receptor protein 2 0.0136 0.0336 0.035
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0075 0.0074
Leishmania major glucose transporter, lmgt1 0.0035 0.0059 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0005 0.0004
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0059 0.0057
Loa Loa (eye worm) phosphatidylinositol 3 0.0225 0.058 0.0607
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0176 0.018
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0031 0.0036
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0062 0.0132 0.013
Brugia malayi hypothetical protein 0.0016 0.0005 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.051 0.1364 0.1427
Mycobacterium tuberculosis Conserved protein 0.0078 0.0176 0.1297
Schistosoma mansoni tar DNA-binding protein 0.0676 0.182 0.1819
Entamoeba histolytica hypothetical protein 0.0074 0.0165 0.0169
Onchocerca volvulus 0.0018 0.001 0.0022
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0005 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0057 0.0056
Echinococcus multilocularis General substrate transporter 0.0098 0.023 0.0229
Trypanosoma brucei glucose transporter, putative 0.0035 0.0059 0.0057
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.0274 0.0273
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0225 0.058 0.0604
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0025 0.0238
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0148 0.0151
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0005 0.0004
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0055 0.0113 0.0114
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0225 0.058 0.0604
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0029 0.004 0.0352
Plasmodium falciparum calcium-dependent protein kinase 5 0.0035 0.0057 0.0404
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.2775 0.7588 0.7945
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.001 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.001 0.0009
Schistosoma mansoni glucose transport protein 0.0114 0.0274 0.0273
Schistosoma mansoni tar DNA-binding protein 0.0676 0.182 0.1819
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0184 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.0274 0.0286
Brugia malayi MH1 domain containing protein 0.0034 0.0056 0.0057
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0025 0.0158
Loa Loa (eye worm) hypothetical protein 0.0294 0.077 0.0806
Loa Loa (eye worm) hypothetical protein 0.0735 0.1982 0.2076
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0225 0.058 0.0602
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0498 0.1332 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0059 0.006
Entamoeba histolytica hypothetical protein 0.0225 0.058 0.0604
Plasmodium vivax CDK-related protein kinase 6, putative 0.0483 0.129 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 0.527 uM PUBCHEM_BIOASSAY: Late-stage fluorescence-based dose response cell-based screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7) Set 5. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 0.53 uM Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR assay ChEMBL. 23287738
IC50 (functional) 8.51 uM PUBCHEM_BIOASSAY: Late-stage fluorescence-based counterscreen for antagonists of the G-protein coupled receptor 7 (GPR7): cell-based dose response assay to identify antagonists of the melanin-concentrating hormone receptor 1 (MCHR1) Set 5. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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