Detailed information for compound 1646724

Basic information

Technical information
  • TDR Targets ID: 1646724
  • Name: (2Z)-N-(2-cyanophenyl)-2-hydrazinylidene-4-ox o-3-(3-oxo-1H-2-benzofuran-1-yl)-4-pyridin-4- ylbutanamide
  • MW: 439.423 | Formula: C24H17N5O4
  • H donors: 2 H acceptors: 5 LogP: 2.81 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N/N=C(/C(C1OC(=O)c2c1cccc2)C(=O)c1ccncc1)\C(=O)Nc1ccccc1C#N
  • InChi: 1S/C24H17N5O4/c25-13-15-5-1-4-8-18(15)28-23(31)20(29-26)19(21(30)14-9-11-27-12-10-14)22-16-6-2-3-7-17(16)24(32)33-22/h1-12,19,22H,26H2,(H,28,31)/b29-20-
  • InChiKey: IJLCEOMLHZLXON-BRPDVVIDSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-cyanophenyl)-2-hydrazinylidene-4-oxo-3-(3-oxo-1H-2-benzofuran-1-yl)-4-pyridin-4-ylbutanamide
  • (2Z)-N-(2-cyanophenyl)-2-hydrazono-4-oxo-3-(3-oxo-1H-isobenzofuran-1-yl)-4-(4-pyridyl)butanamide
  • N-(2-cyanophenyl)-2-hydrazono-4-oxo-3-(3-oxo-1H-isobenzofuran-1-yl)-4-(4-pyridyl)butanamide
  • N-(2-cyanophenyl)-2-hydrazono-4-keto-3-(3-keto-1H-isobenzofuran-1-yl)-4-(4-pyridyl)butyramide
  • (2Z)-N-(2-cyanophenyl)-2-hydrazono-4-keto-3-(3-keto-1H-isobenzofuran-1-yl)-4-(4-pyridyl)butyramide
  • N-(2-cyanophenyl)-2-hydrazinylidene-4-oxo-3-(3-oxo-1H-2-benzofuran-1-yl)-4-pyridin-4-yl-butanamide
  • (2Z)-N-(2-cyanophenyl)-2-hydrazinylidene-4-oxo-3-(3-oxo-1H-2-benzofuran-1-yl)-4-pyridin-4-yl-butanamide
  • AIDS-137381
  • AIDS137381
  • N-(2-Cyanophenyl)-2-hydrazono-4-oxo-3-(3-oxo-1,3-dihydro-2-benzofuran-1-yl)-4-(4-pyridinyl)butanamide
  • NSC641434
  • NCI60_014000

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0131 0.1474 0.2515
Leishmania major heat shock protein 83-1 0.0027 0.0215 0.0296
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0068 0.0096
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0259 0.0454
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0073 0.077 0.0984
Schistosoma mansoni endoplasmin 0.0027 0.0215 0.0275
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0259 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0242 0.0577
Trypanosoma brucei heat shock protein 90, putative 0.0027 0.0215 0.0355
Schistosoma mansoni heat shock protein 0.0027 0.0215 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0307 0.0733
Loa Loa (eye worm) hypothetical protein 0.0131 0.1474 0.2578
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0065 0.0114
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0027 0.0215 0.1137
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0301 0.0446
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.0054 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0259 0.0454
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0259 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0413 0.0989
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0027 0.0215 0.0377
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0259 0.0332
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0108 0.0167
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0259 0.0332
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0014 0.0066 0.0085
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0045 0.0436 0.0474
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0131 0.1474 0.2578
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.008 0.0865 0.1513
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0195 0.2252 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0259 0.0332
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0043 0.0413 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0015 0.0068 0.0159
Brugia malayi hypothetical protein 0.0019 0.0118 0.0206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0173 0.0413
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0043 0.0409 0.0523
Brugia malayi beta-lactamase 0.0131 0.1474 0.2578
Mycobacterium tuberculosis Conserved protein 0.0131 0.1474 0.1427
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.008 0.0865 0.1106
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0259 0.0454
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0027 0.0215 0.0162
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0015 0.0068 0.0159
Mycobacterium tuberculosis Probable esterase LipL 0.0131 0.1474 0.1427
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0259 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0203 0.0485
Trypanosoma brucei heat shock protein, putative 0.0027 0.0215 0.0355
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0068 0.0096
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0168 0.1928 0.856
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0611 0.0781
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.008 0.0865 0.1513
Loa Loa (eye worm) hypothetical protein 0.003 0.0259 0.0454
Brugia malayi Cytochrome P450 family protein 0.0013 0.0054 0.0095
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0027 0.0215 0.0162
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0073 0.077 0.0836
Brugia malayi steroid hormone receptor 0.003 0.0259 0.0454
Mycobacterium tuberculosis Conserved protein 0.0131 0.1474 0.1427
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0259 0.0282
Onchocerca volvulus 0.0014 0.0065 0.0042
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0068 0.0119
Plasmodium falciparum heat shock protein 90 0.0027 0.0215 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0259 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0066 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0259 0.0454
Echinococcus granulosus geminin 0.0128 0.144 0.1841
Brugia malayi hypothetical protein 0.0014 0.0065 0.0114
Leishmania major heat shock protein 83-1 0.0027 0.0215 0.0296
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0034 0.0309 0.0335
Leishmania major heat shock protein 83-1 0.0027 0.0215 0.0296
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0065 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.023 0.055
Schistosoma mansoni heat shock protein 0.0027 0.0215 0.0275
Echinococcus multilocularis ubiquitin specific protease 41 0.0034 0.0309 0.0335
Leishmania major heat shock protein 83-1 0.0027 0.0215 0.0296
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0537 0.2378
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0073 0.077 0.1346
Entamoeba histolytica heat shock protein 90, putative 0.0027 0.0215 0.4584
Brugia malayi Endoplasmin precursor 0.0027 0.0215 0.0377
Loa Loa (eye worm) endoplasmin 0.0027 0.0215 0.0377
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0259 0.0332
Loa Loa (eye worm) cytochrome P450 0.0013 0.0054 0.0095
Mycobacterium leprae conserved hypothetical protein 0.0131 0.1474 1
Schistosoma mansoni thyroid hormone receptor 0.003 0.0259 0.0332
Loa Loa (eye worm) hypothetical protein 0.0019 0.0118 0.0206
Mycobacterium tuberculosis Possible two component sensor kinase 0.0027 0.0215 0.0162
Schistosoma mansoni nuclear receptor 0.0014 0.0065 0.0083
Schistosoma mansoni hypothetical protein 0.0128 0.144 0.1841
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0068 0.0035
Brugia malayi nuclear receptor RXR 0.0014 0.0065 0.0114
Schistosoma mansoni hypothetical protein 0.0388 0.4593 0.5871
Leishmania major phosphatidylinositol 3-kinase, putative 0.0014 0.0066 0.0033
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0311 0.0744
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0027 0.0215 0.0162
Trypanosoma cruzi target of rapamycin kinase 3 0.0034 0.0307 0.0457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0066 0.0156
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0027 0.0215 0.1137
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0259 0.0454
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0259 0.0454
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0068 0.0087
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0259 0.0454
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0259 0.0454
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0259 0.0454
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0309 0.0738
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0309 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0173 0.0413
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0027 0.0215 0.0951
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0118 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0173 0.0412
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.1486 0.2599
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0034 0.0307 0.0457
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0114
Loa Loa (eye worm) hypothetical protein 0.0131 0.1474 0.2578
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0034 0.0309 0.0394
Echinococcus granulosus heat shock protein 90 0.0027 0.0215 0.0275
Echinococcus multilocularis dna polymerase kappa 0.0015 0.0068 0.0074
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0259 0.0282
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.031 0.3648 0.6381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0307 0.0733
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0065 0.0083
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0015 0.0068 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0259 0.0454
Mycobacterium ulcerans beta-lactamase 0.0131 0.1474 1
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0027 0.0215 0.1137
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0048 0.0111
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0131 0.1474 0.1884
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0065 0.0071
Trypanosoma brucei heat shock protein, putative 0.0027 0.0215 0.0355
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0311 0.0744
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0068 0.0546
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0027 0.0215 0.0514
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.0066 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0068 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.028 0.0668
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0259 0.0282
Echinococcus granulosus voltage dependent calcium channel 0.0015 0.0075 0.0096
Trypanosoma cruzi DNA polymerase eta, putative 0.0024 0.0179 0.0231
Leishmania major DNA topoisomerase ii 0.0027 0.0215 0.0296
Echinococcus granulosus RUN 0.0019 0.0118 0.0151
Echinococcus multilocularis survival motor neuron protein 1 0.0399 0.472 0.5125
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0068 0.0096
Leishmania major heat shock protein 83-1 0.0027 0.0215 0.0296
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0027 0.0215 0.0355
Trichomonas vaginalis penicillin-binding protein, putative 0.0131 0.1474 0.3535
Mycobacterium leprae Probable lipase LipE 0.0131 0.1474 1
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0027 0.0215 0.1137
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0056 0.0569 0.0995
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0487 0.0623
Schistosoma mansoni rab6-interacting 0.0019 0.0118 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0031 0.0072
Brugia malayi TAR-binding protein 0.0056 0.0569 0.0995
Echinococcus multilocularis voltage dependent calcium channel 0.0073 0.077 0.0836
Entamoeba histolytica kinesin, putative 0.0018 0.0106 0.158
Echinococcus multilocularis beta LACTamase domain containing family member 0.0131 0.1474 0.16
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0311 0.0744
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0043 0.0413 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0221 0.2574 0.4502
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.015
Echinococcus multilocularis lysosomal alpha glucosidase 0.0156 0.1784 0.1937
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0203 0.0485
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0155 0.0189
Leishmania major cytochrome p450-like protein 0.0013 0.0054 0.0011
Trichomonas vaginalis receptor histidine kinase, putative 0.0027 0.0215 0.0514
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0013 0.0014
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0065 0.0042
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0043 0.0413 0.0449
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0203 0.0485
Plasmodium vivax endoplasmin, putative 0.0027 0.0215 0.0803
Trypanosoma brucei unspecified product 0.0015 0.0068 0.0096
Mycobacterium ulcerans two component regulator - sensor kinase 0.0027 0.0215 0.1137
Plasmodium falciparum DNA topoisomerase 2 0.0027 0.0215 1
Echinococcus granulosus cpg binding protein 0.0029 0.024 0.0307
Leishmania major mitochondrial DNA topoisomerase II 0.0027 0.0215 0.0296
Brugia malayi heat shock protein 90 0.0027 0.0215 0.0377
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0065 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0337 0.0806
Loa Loa (eye worm) hypothetical protein 0.0045 0.0436 0.0763
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.008 0.0865 0.0939
Schistosoma mansoni tar DNA-binding protein 0.0056 0.0569 0.0727
Loa Loa (eye worm) voltage-dependent calcium channel 0.0015 0.0075 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.028 0.0668
Schistosoma mansoni DNA polymerase eta 0.0034 0.0301 0.0384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.028 0.0668
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0131 0.1474 0.1427
Onchocerca volvulus 0.0019 0.0118 0.017
Onchocerca volvulus 0.0131 0.1474 0.3462
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0259 0.0454
Echinococcus granulosus survival motor neuron protein 1 0.0399 0.472 0.6034
Echinococcus granulosus tar DNA binding protein 0.0056 0.0569 0.0727
Echinococcus granulosus dna polymerase kappa 0.0015 0.0068 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.02 0.0477
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0259 0.0454
Schistosoma mansoni hypothetical protein 0.0081 0.0876 0.112
Echinococcus multilocularis kinesin family 1 0.0136 0.154 0.1672
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0027 0.0215 0.5
Schistosoma mansoni amyloid beta A4 protein related 0.0052 0.0519 0.0664
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.0215 0.4271
Schistosoma mansoni voltage-gated cation channel 0.0073 0.077 0.0984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0307 0.0733
Schistosoma mansoni tar DNA-binding protein 0.0056 0.0569 0.0727
Echinococcus granulosus FTZ F1 alpha 0.003 0.0259 0.0332
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0155 0.0271
Loa Loa (eye worm) hypothetical protein 0.0481 0.5717 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0259 0.0282
Brugia malayi Pre-SET motif family protein 0.031 0.3648 0.6381
Loa Loa (eye worm) TOPoisomerase family member 0.0027 0.0215 0.0377
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0068 0.0096
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0259 0.0454
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0045 0.0436 0.0474
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0436 0.0558
Echinococcus multilocularis heat shock protein 0.0027 0.0215 0.0234
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0065 0.0071
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0311 0.0744
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0027 0.0215 0.0296
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0114
Loa Loa (eye worm) hypothetical protein 0.0013 0.0048 0.0084
Loa Loa (eye worm) TAR-binding protein 0.0056 0.0569 0.0995
Leishmania major hypothetical protein, conserved 0.0027 0.0215 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.02 0.0477
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0481 0.5717 0.6206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0173 0.0413
Loa Loa (eye worm) hypothetical protein 0.0131 0.1474 0.2578
Echinococcus granulosus beta LACTamase domain containing family member 0.0131 0.1474 0.1884
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0493 0.0862
Trypanosoma brucei glucosidase, putative 0.0035 0.0311 0.0523
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0068 0.0096
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0065 0.0071
Echinococcus granulosus dnaJ subfamily B 0.0388 0.4593 0.5871
Loa Loa (eye worm) hypothetical protein 0.0399 0.472 0.8257
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0487 0.0623
Brugia malayi hypothetical protein 0.0019 0.0118 0.0206
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0027 0.0215 0.0514
Chlamydia trachomatis DNA gyrase subunit B 0.0027 0.0215 0.5
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0027 0.0215 0.0162
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0048 0.0111
Loa Loa (eye worm) hypothetical protein 0.0027 0.0215 0.0377
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0014 0.0066 0.0033
Brugia malayi Pre-SET motif family protein 0.0045 0.0436 0.0763
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0086 0.011
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0311 0.0744
Loa Loa (eye worm) hypothetical protein 0.0013 0.0053 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0259 0.0454
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0027 0.0215 0.1137
Leishmania major heat shock protein 83-1 0.0027 0.0215 0.0296
Schistosoma mansoni cpg binding protein 0.0029 0.024 0.0307
Plasmodium vivax SET domain protein, putative 0.0045 0.0436 0.2418
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0112 0.1247 0.1354
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0068 0.0074
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0413 0.0723
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0307 0.0733
Schistosoma mansoni hypothetical protein 0.0049 0.0487 0.0623
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0168 0.1928 0.3316
Echinococcus granulosus voltage dependent calcium channel 0.0073 0.077 0.0984
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0311 0.1377
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0048 0.0061
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0027 0.0215 0.0162
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.1774 0.3103
Mycobacterium ulcerans two component sensor kinase MprB 0.0027 0.0215 0.1137
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.015
Echinococcus multilocularis cpg binding protein 0.0029 0.024 0.0261
Echinococcus granulosus ubiquitin specific protease 41 0.0034 0.0309 0.0394
Schistosoma mansoni tar DNA-binding protein 0.0056 0.0569 0.0727
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0215 0.0514
Echinococcus multilocularis GPCR, family 2 0.0049 0.0487 0.0529
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0027 0.0215 0.0407
Trypanosoma brucei DNA polymerase eta, putative 0.0034 0.0301 0.0504
Schistosoma mansoni cytochrome P450 0.0013 0.0054 0.0069
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0068 0.0096
Loa Loa (eye worm) hypothetical protein 0.0131 0.1474 0.2578
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0086 0.011
Onchocerca volvulus 0.0081 0.0876 0.2012
Loa Loa (eye worm) hypothetical protein 0.0013 0.0053 0.0093
Trichomonas vaginalis sensor histidine kinase, putative 0.0027 0.0215 0.0514
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0114
Plasmodium falciparum DNA gyrase subunit B 0.0027 0.0215 1
Brugia malayi MH2 domain containing protein 0.0132 0.1486 0.2599
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0065 0.0083
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.008 0.0865 0.0939
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0259 0.0282
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0045 0.0436 0.0558
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0259 0.0282
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0027 0.0215 0.0951
Trypanosoma cruzi Heat shock protein 83, putative 0.0027 0.0215 0.0296
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0259 0.0332
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0048 0.0111
Trypanosoma brucei heat shock protein, putative 0.0027 0.0215 0.0355
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0027 0.0215 0.5
Loa Loa (eye worm) hypothetical protein 0.0131 0.1474 0.2578
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0114
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0027 0.0215 0.0275
Schistosoma mansoni hypothetical protein 0.0118 0.1326 0.1695
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0259 0.0282
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0027 0.0215 0.0514
Leishmania major DNA polymerase eta, putative 0.0024 0.0179 0.0231
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0259 0.0332
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0311 0.0744
Brugia malayi ecdysteroid receptor 0.003 0.0259 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0173 0.0412
Brugia malayi Probable DNA topoisomerase II 0.0027 0.0215 0.0377
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0481 0.5717 0.6206
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0045 0.0436 0.1933
Brugia malayi Doublecortin family protein 0.0019 0.0118 0.0206
Schistosoma mansoni polycystin 1-related 0.0019 0.0118 0.0151
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0114
Schistosoma mansoni microtubule-associated protein tau 0.0655 0.7823 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0048 0.0111
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0131 0.1474 0.1884
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0118 0.0091
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0048 0.0111
Leishmania major heat shock protein 83-1 0.0027 0.0215 0.0296
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.008 0.0865 0.1106
Schistosoma mansoni coup transcription factor 0.003 0.0259 0.0332
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0068 0.0119
Schistosoma mansoni hypothetical protein 0.0013 0.0054 0.0069
Schistosoma mansoni survival motor neuron protein 0.0081 0.0876 0.112
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0155 0.0249
Echinococcus multilocularis lysosomal alpha glucosidase 0.0156 0.1784 0.1937
Schistosoma mansoni rab6-interacting 0.0019 0.0118 0.0151
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0215 0.0296
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0114
Loa Loa (eye worm) hypothetical protein 0.0027 0.0215 0.0377
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0024 0.0179 0.0789
Schistosoma mansoni pyruvate dehydrogenase 0.0454 0.5393 0.6893
Entamoeba histolytica DNA topoisomerase II, putative 0.0027 0.0215 0.4584
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0013 0.0017
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0065 0.0071
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0311 0.0338
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0487 0.0529
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0086 0.015
Toxoplasma gondii ABC1 family protein 0.0131 0.1474 0.6542
Echinococcus granulosus lysosomal alpha glucosidase 0.0156 0.1784 0.2281
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0086 0.015
Echinococcus granulosus kinesin family 1 0.0136 0.154 0.1969
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0086 0.0093
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0027 0.0215 1
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0215 0.0296
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0065 0.0071
Echinococcus multilocularis dnaJ subfamily B 0.0388 0.4593 0.4986
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0259 0.0454
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0073 0.077 0.0836
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0014 0.0066 0.0033
Loa Loa (eye worm) hypothetical protein 0.003 0.0259 0.0454
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0065 0.0083
Toxoplasma gondii kinesin motor domain-containing protein 0.0018 0.0106 0.0463
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.008 0.0865 0.1106
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0259 0.0514
Giardia lamblia Kinesin-5 0.0018 0.0106 0.1093
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0259 0.0332
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0065 0.0083
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0044 0.0426 0.0667
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0155 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0307 0.0733
Mycobacterium tuberculosis Conserved protein 0.0131 0.1474 0.1427
Brugia malayi Cytochrome P450 family protein 0.0022 0.0155 0.0271
Loa Loa (eye worm) hypothetical protein 0.0106 0.1178 0.2061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.008 0.0865 0.1106
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0769 0.9211 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0043 0.0413 0.0702
Schistosoma mansoni lipoxygenase 0.0078 0.0839 0.1073
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.008 0.0865 0.1106
Schistosoma mansoni endoplasmin 0.0027 0.0215 0.0275
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0034 0.0309 0.0335
Loa Loa (eye worm) hypothetical protein 0.0131 0.1474 0.2578
Brugia malayi ecdysone receptor 0.0014 0.0065 0.0114
Trichomonas vaginalis endoplasmin, putative 0.0027 0.0215 0.0514
Echinococcus granulosus amyloid beta A4 protein 0.0052 0.0519 0.0664
Schistosoma mansoni pyruvate dehydrogenase 0.0481 0.5717 0.7308
Toxoplasma gondii hypothetical protein 0.0013 0.0053 0.023
Trypanosoma brucei developmentally regulated phosphoprotein 0.0481 0.5717 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0013 0.0054 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0173 0.0412
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0073 0.077 0.0984
Brugia malayi hypothetical protein 0.0016 0.0086 0.015
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0034 0.0307 0.0516
Echinococcus multilocularis 0.0013 0.0054 0.0059
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0014 0.0066 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0056 0.0569 0.0727
Loa Loa (eye worm) hypothetical protein 0.003 0.0259 0.0454
Mycobacterium ulcerans DNA polymerase IV 0.0015 0.0068 0.0096
Schistosoma mansoni hypothetical protein 0.0019 0.0118 0.0151
Trypanosoma brucei DNA topoisomerase ii 0.0027 0.0215 0.0355
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0027 0.0215 0.0296
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0065 0.0114
Brugia malayi Cytochrome P450 family protein 0.0022 0.0155 0.0271
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0014 0.0066 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0259 0.0454
Loa Loa (eye worm) hypothetical protein 0.003 0.0259 0.0454
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0309 0.0738
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0027 0.0215 0.0407
Echinococcus multilocularis amyloid beta A4 protein 0.0052 0.0519 0.0564
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0073 0.077 0.0836
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0065 0.0114
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0112 0.1247 0.1594
Loa Loa (eye worm) hypothetical protein 0.0073 0.077 0.1346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.028 0.0668
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0081 0.0876 0.1533
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0311 0.0465
Loa Loa (eye worm) hypothetical protein 0.0155 0.1774 0.3103
Toxoplasma gondii heat shock protein HSP90 0.0027 0.0215 0.0951
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0068 0.0096
Mycobacterium tuberculosis Probable two component sensor kinase 0.0027 0.0215 0.0162
Echinococcus multilocularis sodium channel protein 0.0031 0.0264 0.0287
Leishmania major cytochrome p450-like protein 0.0013 0.0054 0.0011
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0131 0.1474 0.1427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.028 0.0668
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0027 0.0215 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.015
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0065 0.0083
Plasmodium vivax DNA gyrase subunit B, putative 0.0027 0.0215 0.0803
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.1178 0.2061
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0065 0.0114
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0027 0.0215 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0259 0.0454
Schistosoma mansoni alpha-glucosidase 0.0134 0.152 0.1944
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0311 0.0398
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0068 0.0087
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0027 0.0215 0.0162
Leishmania major DNA polymerase eta, putative 0.0034 0.0301 0.0446
Leishmania major heat shock protein 83-1 0.0027 0.0215 0.0296
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0131 0.1474 0.2578
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0131 0.1474 0.1427
Mycobacterium ulcerans esterase/lipase LipP 0.0131 0.1474 1
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0027 0.0215 0.0162
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0014 0.0066 0.0094
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0044 0.0426 0.0724
Leishmania major DNA polymerase kappa, putative 0.0015 0.0068 0.0035
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.015
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0073 0.077 0.0836
Brugia malayi hypothetical protein 0.0014 0.0065 0.0114
Mycobacterium leprae Probable two component sensor kinase MprB 0.0027 0.0215 0.1137
Onchocerca volvulus 0.0131 0.1474 0.3462
Mycobacterium ulcerans DNA polymerase IV 0.0015 0.0068 0.0096
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0131 0.1474 1
Schistosoma mansoni thyroid hormone receptor 0.003 0.0259 0.0332
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0013 0.0054 0.0011
Brugia malayi beta-lactamase family protein 0.0131 0.1474 0.2578
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0259 0.0514
Toxoplasma gondii transporter, cation channel family protein 0.0015 0.0075 0.0328
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0065 0.0114
Trichomonas vaginalis set domain proteins, putative 0.0353 0.4166 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0259 0.0332
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0065 0.0083
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0027 0.0215 0.1137
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0259 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0066 0.0156
Trichomonas vaginalis DNA topoisomerase II, putative 0.0027 0.0215 0.0514
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0114
Onchocerca volvulus 0.0353 0.4166 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0034 0.0309 0.6966
Echinococcus multilocularis voltage dependent calcium channel 0.0073 0.077 0.0836
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0027 0.0215 0.0377
Schistosoma mansoni loxhd1 0.0019 0.0118 0.0151
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0065 0.0083
Loa Loa (eye worm) calcium channel 0.0073 0.077 0.1346
Leishmania major heat shock protein 83-1 0.0027 0.0215 0.0296
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0259 0.0332
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0309 0.046
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0073 0.077 0.0984
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0013 0.0054 0.0072
Brugia malayi nuclear receptor NHR-67 0.0014 0.0065 0.0114
Loa Loa (eye worm) heat shock protein 90 0.0027 0.0215 0.0377
Schistosoma mansoni kinesin eg-5 0.0018 0.0106 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0413 0.0989
Trichomonas vaginalis D-aminoacylase, putative 0.0131 0.1474 0.3535
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0027 0.0215 0.5
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0168 0.1928 0.3357
Onchocerca volvulus 0.009 0.0986 0.2278
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0155 0.0709
Brugia malayi hypothetical protein 0.0399 0.472 0.8257
Echinococcus multilocularis microtubule associated protein 2 0.0655 0.7823 0.8492
Plasmodium falciparum endoplasmin, putative 0.0027 0.0215 1
Trypanosoma cruzi hypothetical protein, conserved 0.0131 0.1474 0.2515
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0311 0.7208
Trypanosoma cruzi DNA topoisomerase II, putative 0.0027 0.0215 0.0296
Schistosoma mansoni alpha glucosidase 0.0035 0.0311 0.0398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0066 0.0156
Echinococcus granulosus cytochrome P450 2K1 0.0013 0.0054 0.0069
Brugia malayi RNA binding protein 0.0056 0.0569 0.0995
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0027 0.0215 0.0162
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0034 0.0309 0.0394
Mycobacterium ulcerans hypothetical protein 0.0131 0.1474 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0487 0.0852
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0311 0.7208
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0027 0.0215 0.0355
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0027 0.0215 0.1137
Mycobacterium tuberculosis Probable hydrolase 0.0131 0.1474 0.1427
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0066 0.0116
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0027 0.0215 0.5
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0309 0.7132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0259 0.0454
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0027 0.0215 0.0407
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0259 0.0282
Plasmodium vivax hypothetical protein, conserved 0.0131 0.1474 1
Trypanosoma brucei heat shock protein, putative 0.0027 0.0215 0.0355
Brugia malayi hypothetical protein 0.0016 0.0086 0.015
Plasmodium vivax heat shock protein 86, putative 0.0027 0.0215 0.0803
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0027 0.0215 0.0514
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0118 0.0151
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0013 0.0054 0.0011
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0027 0.0215 0.1137
Schistosoma mansoni nuclear receptor 0.0014 0.0065 0.0083
Leishmania major developmentally regulated phosphoprotein-like protein 0.0481 0.5717 1
Giardia lamblia Pms1-like protein 0.0027 0.0215 0.4271
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0065 0.0083
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0068 0.0014
Echinococcus multilocularis heat shock protein 90 0.0027 0.0215 0.0234
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0043 0.0413 0.0645
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0068 0.0096
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0065 0.0114
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0034 0.0309 0.0394
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0045 0.0436 0.0558
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0215 0.0296
Leishmania major heat shock protein 83-1 0.0027 0.0215 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0066 0.0156
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0215 0.0296
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0311 0.0744
Mycobacterium tuberculosis Conserved protein 0.0027 0.0215 0.0162
Brugia malayi cytochrome P450 0.0013 0.0054 0.0095
Mycobacterium tuberculosis Probable lipase LipD 0.0131 0.1474 0.1427
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0048 0.0111
Echinococcus granulosus heat shock protein 0.0027 0.0215 0.0275
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0215 0.0296
Loa Loa (eye worm) hypothetical protein 0.003 0.0259 0.0454
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0027 0.0215 0.0355
Leishmania major heat shock protein 83-1 0.0027 0.0215 0.0296
Loa Loa (eye worm) hypothetical protein 0.0034 0.0301 0.0526
Entamoeba histolytica heat shock protein 90, putative 0.0027 0.0215 0.4584
Mycobacterium tuberculosis Probable lipase LipE 0.0131 0.1474 0.1427
Giardia lamblia GTOR 0.0043 0.0413 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0045 0.0436 0.0558
Schistosoma mansoni lipoxygenase 0.0112 0.1247 0.1594
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0027 0.0215 0.5
Brugia malayi kinase, mitochondrial precursor 0.0481 0.5717 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0015 0.0068 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0259 0.0454
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0168 0.1928 0.3316
Echinococcus granulosus dna polymerase eta 0.0034 0.0301 0.0384
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0311 0.0545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0259 0.0454
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0043 0.0413 0.0645
Echinococcus multilocularis RUN 0.0019 0.0118 0.0128
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0073 0.077 0.0984
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0215 0.0514
Brugia malayi conserved hypotetical protein 0.0014 0.0065 0.0114
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0012 0.0021
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0118 0.0151
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0215 0.0803
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0068 0.0035
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0013 0.0054 0.0011
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0043 0.0413 0.0645
Loa Loa (eye worm) X11 protein 0.0052 0.0519 0.0908
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0118 0.0151
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0014 0.0066 0.0085
Trichomonas vaginalis D-aminoacylase, putative 0.0131 0.1474 0.3535
Trypanosoma brucei heat shock protein, putative 0.0027 0.0215 0.0355
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0027 0.0215 0.0296
Schistosoma mansoni cpg binding protein 0.0029 0.024 0.0307
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0068 0.0035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0259 0.0332
Brugia malayi hypothetical protein 0.005 0.0495 0.0865
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0027 0.0215 0.0234
Schistosoma mansoni zinc finger protein 0.0014 0.0065 0.0083
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0481 0.5717 0.7308
Leishmania major heat shock protein 83-1 0.0027 0.0215 0.0296
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0487 0.0852
Trichomonas vaginalis D-aminoacylase, putative 0.0131 0.1474 0.3535
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0114
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0027 0.0215 0.1137
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0046 0.0453 0.0792
Brugia malayi nuclear receptor NHR-88 0.0014 0.0065 0.0114
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0048 0.0111
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0043 0.0413 0.0529
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0259 0.0454
Schistosoma mansoni hypothetical protein 0.0128 0.144 0.1841
Echinococcus granulosus histone lysine methyltransferase setb 0.0045 0.0436 0.0558
Brugia malayi nuclear hormone receptor 0.003 0.0259 0.0454
Brugia malayi tailless protein 0.0014 0.0065 0.0114
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0031 0.0264 0.0337
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0413 0.0723
Echinococcus granulosus microtubule associated protein 2 0.0655 0.7823 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0048 0.0084
Onchocerca volvulus 0.0045 0.0436 0.0944
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0043 0.0413 0.0702
Leishmania major heat shock protein 83-1 0.0027 0.0215 0.0296
Leishmania major cytochrome p450-like protein 0.0022 0.0155 0.0189
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0259 0.0332
Echinococcus multilocularis dna polymerase eta 0.0034 0.0301 0.0326
Toxoplasma gondii DNA topoisomerase 2, putative 0.0027 0.0215 0.0951
Plasmodium vivax DNA topoisomerase II, putative 0.0027 0.0215 0.0803
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0027 0.0215 0.0514
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0065 0.0083
Brugia malayi RNA recognition motif domain containing protein 0.0056 0.0569 0.0995
Trypanosoma brucei heat shock protein 90, putative 0.0027 0.0215 0.0355
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0068 0.0087
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0068 0.0035
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.1486 0.2599
Trypanosoma brucei heat shock protein, putative 0.0027 0.0215 0.0355
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0259 0.0332
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0155 0.0189
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0086 0.011
Schistosoma mansoni hypothetical protein 0.0106 0.1178 0.1506
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0027 0.0215 0.0162
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0118 0.0206
Loa Loa (eye worm) kinesin-like protein KLP2 0.0018 0.0106 0.0185
Schistosoma mansoni nuclear hormone receptor 0.003 0.0259 0.0332
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0156 0.1784 0.3121
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0043 0.0413 0.0529
Brugia malayi nuclear receptor NHR-88 0.003 0.0259 0.0454
Brugia malayi nuclear receptor RXR 0.0016 0.0086 0.015
Schistosoma mansoni cpg binding protein 0.0027 0.0221 0.0283
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0487 0.0529
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.015
Schistosoma mansoni hypothetical protein 0.0049 0.0487 0.0623
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0068 0.0096
Trichomonas vaginalis esterase, putative 0.0131 0.1474 0.3535
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0487 0.0852
Schistosoma mansoni pyruvate dehydrogenase 0.0454 0.5393 0.6893
Leishmania major hypothetical protein, conserved 0.0131 0.1474 0.2515
Toxoplasma gondii heat shock protein 90, putative 0.0027 0.0215 0.0951
Onchocerca volvulus 0.0019 0.0118 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0173 0.0413
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.1774 0.3103
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0114
Onchocerca volvulus 0.0131 0.1474 0.3462
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.0301 0.0526
Loa Loa (eye worm) histone methyltransferase 0.001 0.0013 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0311 0.0465
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0114
Brugia malayi nuclear hormone receptor 0.0014 0.0065 0.0114
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0065 0.0114
Leishmania major heat shock protein 83-1 0.0027 0.0215 0.0296
Loa Loa (eye worm) hypothetical protein 0.003 0.0259 0.0454
Brugia malayi follicle stimulating hormone receptor 0.0221 0.2574 0.4502
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0114
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0311 0.0465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.028 0.0668
Brugia malayi CXXC zinc finger family protein 0.0027 0.0221 0.0387
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0259 0.0454
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0068 0.0096
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0259 0.0332
Loa Loa (eye worm) hypothetical protein 0.003 0.0259 0.0454
Leishmania major heat shock protein 83-1 0.0027 0.0215 0.0296
Trichomonas vaginalis receptor histidine kinase, putative 0.0027 0.0215 0.0514
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0034 0.0309 0.0394
Loa Loa (eye worm) hypothetical protein 0.005 0.0495 0.0865
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.028 0.0668
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0068 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0259 0.0454
Trypanosoma brucei Heat shock protein 83, putative 0.0027 0.0215 0.0355
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0487 0.0852
Brugia malayi Glycosyl hydrolases family 31 protein 0.0156 0.1784 0.3121
Trypanosoma brucei hypothetical protein, conserved 0.0131 0.1474 0.2561
Schistosoma mansoni DNA topoisomerase II 0.0027 0.0215 0.0275
Schistosoma mansoni hypothetical protein 0.0049 0.0487 0.0623
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.1774 0.3103
Mycobacterium ulcerans lipase LipD 0.0131 0.1474 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0027 0.0215 0.0296
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0118 0.0128
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0155 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0413 0.0989
Echinococcus granulosus GPCR family 2 0.0049 0.0487 0.0623
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0014 0.0066 0.0033
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0311 0.0744
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0309 0.046
Loa Loa (eye worm) DR-78 0.0014 0.0065 0.0114
Mycobacterium leprae Probable two-component sensor kinase 0.0027 0.0215 0.1137
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0043 0.0413 0.0645
Onchocerca volvulus 0.0014 0.0065 0.0042
Onchocerca volvulus 0.003 0.0259 0.0514
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0481 0.5717 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0065 0.0083
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0065 0.0114
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0114
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0118 0.0128
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0073 0.077 0.0984
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.002 0.0138 0.022
Loa Loa (eye worm) beta-lactamase 0.0131 0.1474 0.2578
Mycobacterium ulcerans putative regultory protein 0.0027 0.0215 0.1137
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0309 0.0738
Trypanosoma brucei heat shock protein, putative 0.0027 0.0215 0.0355
Leishmania major heat shock protein 83-1 0.0027 0.0215 0.0296
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0311 0.0545
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0118 0.1131
Brugia malayi Cytochrome P450 family protein 0.005 0.0493 0.0862
Onchocerca volvulus 0.0027 0.0221 0.0422
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0065 0.0114
Echinococcus multilocularis tar DNA binding protein 0.0056 0.0569 0.0617
Chlamydia trachomatis DNA gyrase subunit B 0.0027 0.0215 0.5
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0034 0.0309 0.054
Mycobacterium ulcerans DNA gyrase subunit B 0.0027 0.0215 0.1137
Brugia malayi beta-lactamase family protein 0.0131 0.1474 0.2578
Loa Loa (eye worm) hypothetical protein 0.0019 0.0118 0.0206
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0086 0.015
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0311 0.0744
Leishmania major heat shock protein 83-1 0.0027 0.0215 0.0296
Brugia malayi Kinesin motor domain containing protein 0.0018 0.0106 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0068 0.0096
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0027 0.0215 0.0162
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0259 0.0282
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0027 0.0215 0.1137
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0221 0.0387
Loa Loa (eye worm) hypothetical protein 0.003 0.0259 0.0454
Trypanosoma brucei heat shock protein, putative 0.0027 0.0215 0.0355
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0065 0.0071
Loa Loa (eye worm) hypothetical protein 0.0014 0.0065 0.0114
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.028 0.1236
Echinococcus multilocularis geminin 0.0128 0.144 0.1563
Schistosoma mansoni alpha-glucosidase 0.0134 0.152 0.1944
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0259 0.0514
Schistosoma mansoni hypothetical protein 0.0049 0.0487 0.0623
Loa Loa (eye worm) hypothetical protein 0.0015 0.0075 0.0132
Trichomonas vaginalis penicillin-binding protein, putative 0.0131 0.1474 0.3535
Loa Loa (eye worm) hypothetical protein 0.0034 0.0309 0.054
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0048 0.0111
Loa Loa (eye worm) RNA binding protein 0.0056 0.0569 0.0995
Schistosoma mansoni tar DNA-binding protein 0.0056 0.0569 0.0727
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0309 0.046

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.