Detailed information for compound 1650769

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 324.337 | Formula: C16H16N6O2
  • H donors: 0 H acceptors: 5 LogP: 2.53 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cccc(c1)c1nnc2n1nc(cc2)N1CCCCC1
  • InChi: 1S/C16H16N6O2/c23-22(24)13-6-4-5-12(11-13)16-18-17-14-7-8-15(19-21(14)16)20-9-2-1-3-10-20/h4-8,11H,1-3,9-10H2
  • InChiKey: JEYOQYMSSQZLJL-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL No references
Homo sapiens homeodomain interacting protein kinase 2 Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase kinase kinase kinase 4 Starlite/ChEMBL No references
Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha Starlite/ChEMBL No references
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL No references
Homo sapiens cell division cycle 7 Starlite/ChEMBL No references
Homo sapiens CDC-like kinase 4 Starlite/ChEMBL No references
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL No references
Homo sapiens Rho-associated, coiled-coil containing protein kinase 2 Starlite/ChEMBL No references
Homo sapiens interleukin-1 receptor-associated kinase 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Leishmania infantum protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Homeodomain interacting protein kinase protein 1 Get druggable targets OG5_129272 All targets in OG5_129272
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Schistosoma japonicum Protein kinase DC2, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis rho associated protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_129272 All targets in OG5_129272
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_134863 All targets in OG5_134863
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Serine\/threonine protein kinase homolog Get druggable targets OG5_134863 All targets in OG5_134863
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei protein kinase A catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128641 All targets in OG5_128641
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Echinococcus multilocularis proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Schistosoma japonicum ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative Get druggable targets OG5_134863 All targets in OG5_134863
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Mitogen-activated protein kinase kinase kinase kinase 4, putative Get druggable targets OG5_128641 All targets in OG5_128641
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium parvum protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum IPR000437,Prokaryotic membrane lipoprotein lipid attachment site,domain-containing Get druggable targets OG5_128641 All targets in OG5_128641
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Theileria parva cAMP-dependent protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Brugia malayi probable protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Echinococcus granulosus rho-associated protein kinase 1 Get druggable targets OG5_131020 All targets in OG5_131020
Echinococcus multilocularis CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Echinococcus multilocularis Get druggable targets OG5_128641 All targets in OG5_128641
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_129272 All targets in OG5_129272
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126748 All targets in OG5_126748
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans hypothetical protein Get druggable targets OG5_129272 All targets in OG5_129272
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Serine/threonine-protein kinase Pim-3 Get druggable targets OG5_134863 All targets in OG5_134863
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) STE/STE20/MSN protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing Get druggable targets OG5_131020 All targets in OG5_131020
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129189 All targets in OG5_129189
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania donovani protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 1,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K02214 cell division control protein CDC7, putative Get druggable targets OG5_129189 All targets in OG5_129189
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CDC7 protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus granulosus serine:threonine protein kinase mig 15 Get druggable targets OG5_128641 All targets in OG5_128641
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 2,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum Rho-associated protein kinase 1, putative Get druggable targets OG5_131020 All targets in OG5_131020
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K08826 homeodomain interacting protein kinase, putative Get druggable targets OG5_129272 All targets in OG5_129272
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_131020 All targets in OG5_131020
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium knowlesi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126748 All targets in OG5_126748
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Giardia lamblia Kinase, CDC7 Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus homeodomain interacting protein kinase 3 Get druggable targets OG5_129272 All targets in OG5_129272
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis homeodomain interacting protein kinase 3 Get druggable targets OG5_129272 All targets in OG5_129272
Schistosoma japonicum expressed protein Get druggable targets OG5_129272 All targets in OG5_129272
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cpg binding protein 0.003 0.0361 0.0491
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0096 0.0131
Echinococcus multilocularis musashi 0.0027 0.0309 0.042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2179 1
Onchocerca volvulus 0.0037 0.0479 0.0922
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1847 0.8471
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0197 0.3443 0.3443
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1847 0.1847
Schistosoma mansoni hypothetical protein 0.003 0.0362 0.0493
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0241 0.1913
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0096 0.0131
Loa Loa (eye worm) hypothetical protein 0.002 0.0178 0.0178
Leishmania major cathepsin L-like protease 0.0034 0.0425 0.1579
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0178 0.0242
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0425 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0425 0.0667
Leishmania major protein kinase A catalytic subunit isoform 1 0.0053 0.0778 0.3272
Leishmania major cathepsin L-like protease 0.0128 0.2179 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0056 0.0842 0.1146
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.123 0.1673
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0096 0.0131
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0053 0.0778 0.1058
Plasmodium vivax JmjC domain containing protein 0.0016 0.0096 0.0727
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0354 1
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.0952 0.2343
Echinococcus multilocularis CDC7 cell division cycle 7 0.0073 0.1151 0.1566
Echinococcus multilocularis cyclin dependent kinase 0.0056 0.0842 0.1146
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0053 0.0778 0.6013
Onchocerca volvulus 0.003 0.0362 0.0566
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0425 0.0579
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.3162 0.6696
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0077 0.123 0.5628
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0197 0.3443 0.4685
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0056 0.0842 0.0842
Brugia malayi Cathepsin L-like precursor 0.0023 0.0219 0.0219
Brugia malayi Cathepsin L-like precursor 0.0023 0.0219 0.0219
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0035 0.0448 0.061
Echinococcus granulosus rho-associated protein kinase 1 0.018 0.3138 0.427
Leishmania major DNA polymerase kappa, putative 0.0019 0.0157 0.0292
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0479 0.0809
Entamoeba histolytica protein kinase, putative 0.0062 0.0952 0.2343
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0178 0.0242
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0062 0.0952 0.1295
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0331 0.0331
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0048 0.0692 0.0941
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.1847 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0299 0.0299
Brugia malayi jmjC domain containing protein 0.0016 0.0096 0.0096
Schistosoma mansoni protein kinase 0.0035 0.0448 0.061
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0046 0.0063
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0178 0.0242
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0425 0.0667
Brugia malayi phosphofructokinase 0.011 0.1847 0.1847
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0241 0.1279
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.2179 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0056 0.0842 0.2033
Schistosoma mansoni intermediate filament proteins 0.0027 0.0309 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0425 0.0667
Schistosoma mansoni serine/threonine protein kinase 0.0208 0.3662 0.4984
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0077 0.123 0.5548
Brugia malayi jmjC domain containing protein 0.006 0.0908 0.0908
Mycobacterium tuberculosis Conserved protein 0.0037 0.0479 0.0809
Onchocerca volvulus 0.0175 0.3052 0.8802
Echinococcus granulosus geminin 0.0341 0.6117 0.8325
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0157 0.0214
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0178 0.0178
Loa Loa (eye worm) fibroinase 0.0034 0.0425 0.0425
Giardia lamblia Kinase, CDC7 0.0073 0.1151 0.9266
Loa Loa (eye worm) hypothetical protein 0.0037 0.0479 0.0479
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.003 0.0362 0.1635
Schistosoma mansoni lamin 0.0027 0.0309 0.042
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0056 0.0842 0.658
Brugia malayi Protein kinase domain containing protein 0.0197 0.3443 0.3443
Brugia malayi Protein kinase domain containing protein 0.0056 0.0842 0.0842
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.123 0.2439
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.4662 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0056 0.0842 0.0842
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.003 0.0362 0.0493
Echinococcus multilocularis dna polymerase eta 0.0019 0.0157 0.0214
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1847 0.2513
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0062 0.0952 0.1295
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0122 0.0167
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0425 0.0667
Echinococcus granulosus lamin dm0 0.0027 0.0309 0.042
Echinococcus multilocularis cysteine protease 0.0034 0.0425 0.0579
Loa Loa (eye worm) beta-lactamase 0.0037 0.0479 0.0479
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0062 0.0952 0.7549
Loa Loa (eye worm) hypothetical protein 0.0037 0.0479 0.0479
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.003 0.0362 0.1635
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0354 0.0509
Leishmania major cathepsin L-like protease 0.0034 0.0425 0.1579
Leishmania major cathepsin L-like protease 0.0128 0.2179 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.0157 0.0214
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0197 0.3443 0.4685
Onchocerca volvulus 0.0034 0.0425 0.0758
Schistosoma mansoni cpg binding protein 0.003 0.0361 0.0491
Echinococcus multilocularis dual specificity protein kinase clk2 0.0077 0.123 0.1673
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1847 0.8443
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.4662 1
Onchocerca volvulus 0.0034 0.0425 0.0758
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0925 0.1259
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0157 0.0518
Onchocerca volvulus 0.0034 0.0425 0.0758
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0178 0.0242
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0354 0.2272
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0354 0.2834
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0842 0.1585
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0178 0.0178
Brugia malayi Cathepsin L-like precursor 0.0011 0.0007 0.0007
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0077 0.1224 0.1224
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0479 0.1903
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0178 0.0242
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0096 0.0233
Echinococcus granulosus cyclin dependent kinase 5 0.0056 0.0842 0.1146
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0178 0.0178
Echinococcus granulosus cyclin dependent kinase 0.0056 0.0842 0.1146
Loa Loa (eye worm) hypothetical protein 0.0023 0.0219 0.0219
Brugia malayi beta-lactamase family protein 0.0037 0.0479 0.0479
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0157 0.0518
Mycobacterium ulcerans hypothetical protein 0.0037 0.0479 0.1903
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2991 0.6318
Onchocerca volvulus 0.0073 0.1151 0.2981
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Toxoplasma gondii cathepsin CPL 0.0034 0.0425 0.2902
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0077 0.123 1
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0479 0.0809
Leishmania major cathepsin L-like protease 0.0034 0.0425 0.1579
Echinococcus granulosus cyclin dependent kinase 1 0.0056 0.0842 0.1146
Echinococcus multilocularis cpg binding protein 0.003 0.0361 0.0491
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1847 0.3799
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.003 0.0362 0.0493
Loa Loa (eye worm) hypothetical protein 0.0084 0.1366 0.1366
Loa Loa (eye worm) hypothetical protein 0.003 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.0016 0.0096 0.0096
Plasmodium vivax vivapain-2 0.0034 0.0425 0.3418
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0178 0.0178
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0425 0.0425
Echinococcus granulosus dnaJ subfamily B 0.0407 0.7349 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0011 0.0007 0.0007
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0425 0.0579
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0178 0.0242
Toxoplasma gondii AGC kinase 0.0053 0.0778 0.6013
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0425 0.1924
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0178 0.0242
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0479 0.0651
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0178 0.0178
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0178 0.0242
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0908 0.1236
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.2991 0.8615
Leishmania major protein kinase, putative 0.0077 0.123 0.5442
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0354 0.0509
Echinococcus multilocularis cyclin dependent kinase 1 0.0056 0.0842 0.1146
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2179 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0219 0.0212
Loa Loa (eye worm) hypothetical protein 0.0019 0.0157 0.0157
Leishmania major cathepsin L-like protease 0.0128 0.2179 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0178 0.0242
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0952 0.1827
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0178 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0425 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0425 0.0667
Plasmodium falciparum cysteine proteinase falcipain 1 0.0017 0.0122 0.0232
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0241 0.0497
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.1847 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0056 0.0842 0.2033
Trypanosoma cruzi cruzipain precursor, putative 0.0128 0.2179 1
Echinococcus granulosus cathepsin L 0.0017 0.0122 0.0167
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2991 0.6318
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0178 0.0178
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1847 0.1847
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0479 0.0785
Trypanosoma brucei cdc2-related kinase 1 0.0056 0.0842 0.373
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0425 0.2902
Leishmania major protein kinase A catalytic subunit 0.0053 0.0778 0.3272
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0077 0.123 0.123
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0479 0.1903
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0157 0.069
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0354 0.2272
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0053 0.0778 0.1058
Brugia malayi 6-phosphofructokinase 0.011 0.1847 0.1847
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.1366 0.1859
Giardia lamblia Kinase, AGC PKA 0.0053 0.0778 0.5787
Onchocerca volvulus 0.0034 0.0425 0.0758
Leishmania major protein kinase A catalytic subunit isoform 2 0.0053 0.0778 0.3272
Loa Loa (eye worm) hypothetical protein 0.002 0.0178 0.0178
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0035 0.0448 0.061
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0197 0.3443 1
Schistosoma mansoni jumonji domain containing protein 0.006 0.0908 0.1236
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0241 0.1279
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0842 0.1146
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0448 0.061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0425 0.0667
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0178 0.0178
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0178 0.0178
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0354 0.1834
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2179 1
Leishmania major ATP-dependent phosphofructokinase 0.011 0.1847 0.8406
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0122 0.053
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0056 0.0842 0.1146
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0062 0.0952 0.1295
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0219 0.0272
Brugia malayi Temporarily assigned gene name protein 59 0.003 0.0362 0.0362
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0062 0.0952 0.4349
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0425 0.1579
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0178 0.0242
Brugia malayi beta-lactamase 0.0037 0.0479 0.0479
Schistosoma mansoni rap gtpase-activating protein 0.003 0.0362 0.0493
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0157 0.0518
Mycobacterium ulcerans beta-lactamase 0.0037 0.0479 0.1903
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0944 0.4656
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.1151 0.1566
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0178 0.0178
Echinococcus multilocularis lamin 0.0027 0.0309 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0425 0.0667
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0096 0.0131
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0096 0.0409
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0126 0.0172
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1847 0.4872
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1847 0.3799
Plasmodium vivax unspecified product 0.0017 0.0122 0.0942
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0908 0.1236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0219 0.0212
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.1366 0.1859
Schistosoma mansoni nuclear hormone receptor 0.002 0.0178 0.0242
Trypanosoma brucei cdc2-related kinase 3 0.0056 0.0842 0.373
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0166 0.288 0.7789
Onchocerca volvulus 0.0029 0.0331 0.0469
Loa Loa (eye worm) hypothetical protein 0.0037 0.0479 0.0479
Brugia malayi probable protein kinase 0.0107 0.1786 0.1786
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0944 0.1285
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.2179 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.1847 0.4253
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0354 0.0653
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0178 0.0178
Schistosoma mansoni cpg binding protein 0.0029 0.0331 0.045
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.4662 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0479 0.0651
Echinococcus multilocularis rho associated protein kinase 0.018 0.3138 0.427
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0056 0.0842 0.3581
Loa Loa (eye worm) CDC7 protein kinase 0.0073 0.1151 0.1151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2179 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0425 0.0667
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0262 0.4662 0.4662
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0178 0.0242
Onchocerca volvulus 0.0062 0.0952 0.2371
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0178 0.0178
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1847 0.3799
Brugia malayi jmjC domain containing protein 0.0016 0.0096 0.0096
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0178 0.0242
Brugia malayi Protein kinase domain containing protein 0.0073 0.1151 0.1151
Loa Loa (eye worm) hypothetical protein 0.003 0.0362 0.0362
Echinococcus granulosus intermediate filament protein 0.0027 0.0309 0.042
Entamoeba histolytica PH domain containing protein kinase, putative 0.0053 0.0778 0.1851
Toxoplasma gondii ABC1 family protein 0.0037 0.0479 0.3375
Loa Loa (eye worm) hypothetical protein 0.0016 0.0096 0.0096
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0425 0.0855
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0053 0.0778 0.3548
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1847 0.4872
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1847 0.2513
Brugia malayi cell division control protein 2 homolog 0.0056 0.0842 0.0842
Loa Loa (eye worm) phosphofructokinase 0.011 0.1847 0.1847
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.4662 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.0037
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0166 0.288 0.7789
Brugia malayi nuclear receptor NHR-88 0.002 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0027 0.0309 0.0309
Onchocerca volvulus 0.0027 0.0309 0.0401
Schistosoma mansoni protein kinase 0.0077 0.1224 0.1666
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0241 0.1279
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.2179 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0157 0.0076
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0425 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0425 0.0667
Loa Loa (eye worm) hypothetical protein 0.0102 0.17 0.17
Trypanosoma cruzi cdc2-related kinase 3 0.0056 0.0842 0.3844
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0157 0.069
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0157 0.069
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0046 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0157 0.0518
Loa Loa (eye worm) hypothetical protein 0.002 0.0178 0.0178
Giardia lamblia Kinase, CMGC GSK 0.0062 0.0952 0.741
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1847 0.4872
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.1847 0.2513
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0354 0.0509
Plasmodium vivax protein kinase Crk2 0.0056 0.0842 0.6829
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0053 0.0778 0.3429
Trypanosoma cruzi cdc2-related kinase 1 0.0056 0.0842 0.3844
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.4131 1
Schistosoma mansoni cathepsin s 0.0011 0.0007 0.001
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0035 0.0448 0.061
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0944 0.4656
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0053 0.0778 0.3429
Schistosoma mansoni coup transcription factor 0.002 0.0178 0.0242
Echinococcus multilocularis cysteine protease 0.0034 0.0425 0.0579
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0178 0.0178
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.4662 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0178 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2179 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0157 0.0518
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0479 0.0479
Onchocerca volvulus 0.0084 0.1366 0.3639
Trichomonas vaginalis CMGC family protein kinase 0.0073 0.1151 0.2265
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0448 0.061
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0178 0.0242
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0122 0.0356
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0938 0.1277
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0178 0.0178
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0096 0.0409
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0944 0.1285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2179 1
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0208 0.3662 0.4984
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0178 0.0178
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0096 0.0096
Loa Loa (eye worm) AGC/PKA protein kinase 0.0053 0.0778 0.0778
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0053 0.0778 0.1058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0425 0.0667
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0157 0.0157
Loa Loa (eye worm) AGC/PKA protein kinase 0.0053 0.0778 0.0778
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0938 0.1277
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0178 0.0242
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0219 0.0219
Mycobacterium tuberculosis Conserved protein 0.0037 0.0479 0.0809
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0157 0.0518
Entamoeba histolytica cysteine protease, putative 0.0034 0.0425 0.0855
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0073 0.0073
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0056 0.0842 0.0842
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0126 0.0172
Giardia lamblia Kinase, CMGC CDK 0.0056 0.0842 0.6386
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0122 0.053
Giardia lamblia Kinase, CMGC GSK 0.0062 0.0952 0.741
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0157 0.0518
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0178 0.0178
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0208 0.3662 0.3662
Brugia malayi Protein kinase domain containing protein 0.0035 0.0448 0.0448
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0122 0.053
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0425 0.0855
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0035 0.0448 0.061
Echinococcus multilocularis lamin dm0 0.0027 0.0309 0.042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0219 0.0219
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0354 0.2272
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0178 0.0242
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0425 0.0758
Trypanosoma cruzi major cysteine proteinase, putative 0.0101 0.167 0.7656
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0157 0.069
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0241 0.0497
Brugia malayi jmjC domain containing protein 0.0016 0.0096 0.0096
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0354 0.0509
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0157 0.0518
Brugia malayi beta-lactamase family protein 0.0037 0.0479 0.0479
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0157 0.0292
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0425 0.0667
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0053 0.0778 0.3548
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0157 0.0214
Brugia malayi Cathepsin L-like precursor 0.0034 0.0425 0.0425
Loa Loa (eye worm) hypothetical protein 0.002 0.0178 0.0178
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0178 0.0242
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0122 0.0167
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0035 0.0448 0.061
Onchocerca volvulus 0.0034 0.0425 0.0758
Leishmania major DNA polymerase eta, putative 0.0019 0.0157 0.0292
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0062 0.0952 0.4108
Loa Loa (eye worm) cysteine protease 0.0034 0.0425 0.0425
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0122 0.0122
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0122 0.0167
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0178 0.0242
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0309 0.0309
Leishmania major hypothetical protein, conserved 0.0037 0.0479 0.1836
Giardia lamblia Kinase, CMGC CLK 0.0077 0.123 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0178 0.0242
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0077 0.123 0.5548
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0944 0.198
Loa Loa (eye worm) hypothetical protein 0.002 0.0178 0.0178
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0842 0.1585
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2991 0.6318
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0178 0.0178
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0178 0.0242
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0178 0.0242
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0425 0.0667
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0479 0.2026
Brugia malayi 6-phosphofructokinase 0.011 0.1847 0.1847
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0077 0.123 0.5628
Loa Loa (eye worm) hypothetical protein 0.003 0.0362 0.0362
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0157 0.0076
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0479 0.0479
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2991 0.6318
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0102 0.17 0.2313
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0197 0.3443 0.3443
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0354 0.0509
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.7349 1
Onchocerca volvulus 0.0027 0.0309 0.0401
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0096 0.0131
Loa Loa (eye worm) hypothetical protein 0.002 0.0178 0.0178
Plasmodium falciparum protein kinase 5 0.0056 0.0842 0.658
Trypanosoma brucei protein kinase, putative 0.0062 0.0952 0.4245
Mycobacterium tuberculosis Conserved protein 0.0037 0.0479 0.0809
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0096 0.0131
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0053 0.0778 0.1058
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0425 0.0425
Echinococcus granulosus lamin 0.0027 0.0309 0.042
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0096 0.0131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2179 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0157 0.0098
Brugia malayi Cathepsin L-like precursor 0.0034 0.0425 0.0425
Brugia malayi Cathepsin L-like precursor 0.0034 0.0425 0.0425
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0157 0.0518
Onchocerca volvulus 0.0034 0.0425 0.0758
Trypanosoma brucei unspecified product 0.0019 0.0157 0.0518
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0354 0.0701
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0178 0.0242
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0425 0.0579
Echinococcus granulosus hypothetical protein 0.0072 0.1144 0.1556
Brugia malayi Cathepsin L-like precursor 0.0034 0.0425 0.0425
Trypanosoma cruzi cdc2-related kinase 1 0.0056 0.0842 0.3844
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0208 0.3662 0.4984
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0425 0.0667
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0425 0.0667
Echinococcus granulosus protein kinase 0.0077 0.1224 0.1666
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2991 0.6318
Echinococcus granulosus dna polymerase kappa 0.0019 0.0157 0.0214
Loa Loa (eye worm) hypothetical protein 0.0016 0.0096 0.0096
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0479 0.2171
Plasmodium falciparum protein serine/threonine kinase-1 0.0077 0.123 1
Toxoplasma gondii AGC kinase 0.0053 0.0778 0.6013
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.4662 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.1847 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0309 0.0309
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0241 0.0212
Echinococcus granulosus CDC7 cell division cycle 7 0.0073 0.1151 0.1566
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0053 0.0778 0.3429
Echinococcus multilocularis 0.0072 0.1144 0.1556
Onchocerca volvulus 0.0034 0.0425 0.0758
Loa Loa (eye worm) hypothetical protein 0.0023 0.0219 0.0219
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0241 0.0696
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0479 0.0809
Echinococcus multilocularis cyclin dependent kinase 5 0.0056 0.0842 0.1146
Echinococcus granulosus Vam6:Vps39 protein 0.003 0.0362 0.0493
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0908 0.1236
Schistosoma mansoni thyroid hormone receptor 0.002 0.0178 0.0242
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0354 0.2272
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0425 0.0579
Loa Loa (eye worm) hypothetical protein 0.002 0.0178 0.0178
Echinococcus granulosus FTZ F1 alpha 0.002 0.0178 0.0242
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0062 0.0952 0.0952
Leishmania major cathepsin L-like protease 0.0034 0.0425 0.1579
Plasmodium vivax glycogen synthase kinase 3, putative 0.0062 0.0952 0.7727
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0944 0.748
Entamoeba histolytica hypothetical protein 0.0024 0.0241 0.0335
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0425 0.0425
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0778 0.1058
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0842 0.1146
Brugia malayi hypothetical protein 0.003 0.0362 0.0362
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0035 0.0448 0.061
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0479 0.0809
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0479 0.0785
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0219 0.0298
Mycobacterium leprae Probable lipase LipE 0.0037 0.0479 0.1479
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0354 0.2834
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0166 0.288 0.288
Trichomonas vaginalis esterase, putative 0.0037 0.0479 0.0785
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0048 0.0692 0.0941
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0157 0.0214
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.0037
Echinococcus granulosus dual specificity protein kinase clk2 0.0077 0.123 0.1673
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0157 0.0157
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0425 0.0758
Brugia malayi Cathepsin L-like precursor 0.0034 0.0425 0.0425
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0944 0.1285
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0096 0.0131
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0354 0.2272
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0425 0.0667
Schistosoma mansoni vam6/vps39 related 0.003 0.0362 0.0493
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0122 0.053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0178 0.0178
Schistosoma mansoni serine/threonine protein kinase 0.018 0.3138 0.427
Schistosoma mansoni lamin 0.0027 0.0309 0.042
Brugia malayi jmjC domain containing protein 0.0016 0.0096 0.0096
Echinococcus granulosus cysteine protease 0.0017 0.0122 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0178 0.0178
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0178 0.0242
Brugia malayi Protein kinase domain containing protein 0.0077 0.123 0.123
Onchocerca volvulus 0.0073 0.1151 0.2981
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.003 0.0362 0.0493
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0805 0.6254
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0425 0.0579
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0479 0.0809
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0122 0.0167
Brugia malayi ecdysteroid receptor 0.002 0.0178 0.0178
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0309 0.0309
Plasmodium vivax serine/threonine kinase-1, putative 0.0077 0.123 1
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.3162 0.6696
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0262 0.4662 0.4662
Brugia malayi cathepsin L-like precursor 0.0023 0.0219 0.0219
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.0952 0.2343
Schistosoma mansoni protein kinase 0.0107 0.1786 0.243
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0157 0.069
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0479 0.0809
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0778 0.1443
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0053 0.0778 0.1058
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0479 0.0785
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0842 0.1585
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2991 0.6318
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0096 0.0131
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.1366 0.1859
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1847 0.3799
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2991 0.6318
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.1366 0.1366
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2179 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0157 0.0157
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0077 0.123 0.5628
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0354 1
Onchocerca volvulus 0.0023 0.0219 0.0126
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0117 0.1973 0.905
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0178 0.0242
Onchocerca volvulus 0.0037 0.0479 0.0922
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0425 0.0667
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0479 0.0809
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0479 0.2171
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0056 0.0842 0.3581
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0157 0.0518
Leishmania major cathepsin L-like protease 0.0034 0.0425 0.1579
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0157 0.0518
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0425 0.0579
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0178 0.0242
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0197 0.3443 0.3443
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0053 0.0778 0.3548
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Entamoeba histolytica protein kinase domain containing protein 0.0208 0.3662 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0157 0.0518
Brugia malayi intracellular kinase 0.0062 0.0952 0.0952
Brugia malayi steroid hormone receptor 0.002 0.0178 0.0178
Trichomonas vaginalis CMGC family protein kinase 0.0073 0.1151 0.2265
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0122 0.0122
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0944 0.1285
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0053 0.0778 0.3548
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0354 0.0509
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0178 0.0242
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0479 0.0785
Loa Loa (eye worm) hypothetical protein 0.0072 0.1144 0.1144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0425 0.0667
Plasmodium vivax vivapain-3 0.0017 0.0122 0.0942
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0479 0.1479
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0425 0.2902
Schistosoma mansoni hypothetical protein 0.0407 0.7349 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0178 0.0178
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.055 1 1
Echinococcus multilocularis cathepsin L 0.0017 0.0122 0.0167
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0053 0.0778 0.1058
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.003 0.0362 0.1481
Echinococcus granulosus protein kinase shaggy 0.0062 0.0952 0.1295
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0157 0.0518
Entamoeba histolytica PH domain containing protein kinase, putative 0.0053 0.0778 0.1851
Brugia malayi cathepsin F-like cysteine proteinase 0.0011 0.0007 0.0007
Echinococcus granulosus cathepsin l1 0.0023 0.0219 0.0298
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0157 0.0518
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0778 0.1058
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0425 0.0667
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0479 0.0651
Brugia malayi nuclear hormone receptor 0.002 0.0178 0.0178
Onchocerca volvulus 0.018 0.3138 0.9065
Loa Loa (eye worm) hypothetical protein 0.002 0.0178 0.0178
Echinococcus multilocularis protein kinase shaggy 0.0062 0.0952 0.1295
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0157 0.0214
Loa Loa (eye worm) hypothetical protein 0.0052 0.0756 0.0756
Mycobacterium ulcerans lipase LipD 0.0037 0.0479 0.1903
Leishmania major protein kinase, putative 0.0077 0.123 0.5442
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0178 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0037 0.0479 0.0479
Brugia malayi CXXC zinc finger family protein 0.0029 0.0331 0.0331
Trypanosoma cruzi cdc2-related kinase 3 0.0056 0.0842 0.3844
Loa Loa (eye worm) hypothetical protein 0.0034 0.0425 0.0425
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0479 0.0785
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.123 0.1673
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0425 0.2902
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0077 0.123 0.5628
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0938 0.0938
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0053 0.0778 0.1058
Loa Loa (eye worm) hypothetical protein 0.0037 0.0479 0.0479
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0241 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0178 0.0242
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0208 0.3662 0.3662
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0944 0.407
Onchocerca volvulus 0.0037 0.0479 0.0922
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0938 0.1277
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0096 0.0131
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0425 0.0667
Echinococcus granulosus 6 phosphofructokinase 0.011 0.1847 0.2513
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0425 0.0758
Echinococcus granulosus cathepsin l1 0.0034 0.0425 0.0579
Schistosoma mansoni hypothetical protein 0.0341 0.6117 0.8325
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0479 0.3857
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0122 0.053
Brugia malayi intermediate filament protein 0.0027 0.0309 0.0309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0425 0.0667
Echinococcus granulosus dna polymerase eta 0.0019 0.0157 0.0214
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0096 0.0131
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.003 0.0362 0.0493
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0157 0.0214
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.3443 0.4685
Echinococcus granulosus phd:f box containing protein 0.0016 0.0096 0.0131
Plasmodium falciparum glycogen synthase kinase 3 0.0062 0.0952 0.7549
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2179 1
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0241 0.0912
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0425 0.0579
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0053 0.0778 0.6303
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0354 0.0509
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0096 0.0131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2179 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0178 0.0242
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0778 0.1058
Brugia malayi Cathepsin L-like precursor 0.0034 0.0425 0.0425
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0479 0.0651
Giardia lamblia Kinase, CMGC CDK 0.0056 0.0842 0.6386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0425 0.0667
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0952 0.1827
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0053 0.0778 0.6013
Brugia malayi jmjC domain containing protein 0.0061 0.0938 0.0938
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0053 0.0778 0.0778
Plasmodium vivax vivapain-2 0.0034 0.0425 0.3418
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0096 0.0096
Loa Loa (eye worm) ctsf protein 0.0034 0.0425 0.0425
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0035 0.0448 0.0448
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0062 0.0952 0.0952
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0122 0.0356
Echinococcus granulosus cpg binding protein 0.003 0.0361 0.0491
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0178 0.0178
Echinococcus multilocularis geminin 0.0341 0.6117 0.8325
Plasmodium vivax vivapain-1 0.0017 0.0122 0.0942
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0053 0.0778 0.0778
Schistosoma mansoni hypothetical protein 0.0341 0.6117 0.8325
Trichomonas vaginalis CMGC family protein kinase 0.0073 0.1151 0.2265
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0425 0.0579
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.2179 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0944 0.4656
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0425 0.0667
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0037 0.0479 0.0479
Echinococcus multilocularis 0.0077 0.1224 0.1666
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0096 0.0096

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: IRAK4 ChEMBL. No reference
Ki (functional) > 5.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ROCK2 ChEMBL. No reference
Ki (functional) > 5.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKACA ChEMBL. No reference
Ki (functional) = 6.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAP4K4 ChEMBL. No reference
Ki (functional) = 6.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK2 ChEMBL. No reference
Ki (functional) = 7.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: GSK3B ChEMBL. No reference
Ki (functional) = 7.5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PIM1 ChEMBL. No reference
Ki (functional) = 7.9 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: HIPK2 ChEMBL. No reference
Ki (functional) = 8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CLK4 ChEMBL. No reference
Ki (functional) = 8.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDC7 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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