Detailed information for compound 169188

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 558.708 | Formula: C34H42N2O5
  • H donors: 4 H acceptors: 4 LogP: 5.23 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(OC(C)(C)C)N[C@H]([C@H](C[C@H](C(=O)N[C@H]1[C@H](O)CCc2c1cccc2)Cc1ccccc1)O)Cc1ccccc1
  • InChi: 1S/C34H42N2O5/c1-34(2,3)41-33(40)35-28(21-24-14-8-5-9-15-24)30(38)22-26(20-23-12-6-4-7-13-23)32(39)36-31-27-17-11-10-16-25(27)18-19-29(31)37/h4-17,26,28-31,37-38H,18-22H2,1-3H3,(H,35,40)(H,36,39)/t26-,28+,29-,30+,31-/m1/s1
  • InChiKey: IMGCDQHXXAQTBJ-UADDYFSRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei variant surface glycoprotein (VSG), putative Human immunodeficiency virus type 1 protease   99 aa 80 aa 27.5 %
Giardia lamblia DNA-directed RNA polymerase subunit D Human immunodeficiency virus type 1 protease   99 aa 90 aa 27.8 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Echinococcus multilocularis Chromobox protein 3 Human immunodeficiency virus type 1 protease   99 aa 95 aa 28.4 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Mycobacterium leprae Hypothetical protein Human immunodeficiency virus type 1 protease   99 aa 86 aa 27.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.004 0.004 0.0114
Schistosoma mansoni brca1-associated protein (brap2) 0.0031 0.0013 0.0028
Onchocerca volvulus 0.0048 0.0066 0.0701
Echinococcus granulosus histone deacetylase 1 0.0648 0.1914 0.4497
Loa Loa (eye worm) hypothetical protein 0.0035 0.0026 0.0062
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0066 0.0155
Onchocerca volvulus Cathepsin F homolog 0.0298 0.0835 0.8867
Plasmodium vivax calpain, putative 0.0201 0.0538 0.2239
Leishmania major cathepsin L-like protease 0.0298 0.0835 0.3507
Echinococcus granulosus BRCA1 associated protein 0.0031 0.0013 0.0031
Trichomonas vaginalis replication factor C large subunit, putative 0.004 0.004 0.0141
Loa Loa (eye worm) hypothetical protein 0.0534 0.1562 0.3671
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0241
Giardia lamblia Histone deacetylase 0.0648 0.1914 1
Leishmania major histone deacetylase, putative 0.0792 0.2358 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0136 0.032
Brugia malayi Cathepsin L-like precursor 0.0211 0.0569 0.1336
Schistosoma mansoni integrin alpha-ps 0.0035 0.0026 0.0057
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0172 0.0403
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0061 0.0104 0.0389
Echinococcus multilocularis histone deacetylase 0.0792 0.2358 0.2358
Toxoplasma gondii EF hand domain-containing protein 0.0037 0.0032 0.008
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0031 0.0013 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Echinococcus multilocularis tar DNA binding protein 0.0194 0.0514 0.0514
Giardia lamblia Cysteine protease 0.0085 0.0178 0.0868
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0031 0.0013 0.0028
Onchocerca volvulus 0.0298 0.0835 0.8867
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.0358 0.0841
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.004 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0085 0.0178 0.0868
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0201 0.0538 0.139
Onchocerca volvulus 0.0037 0.0032 0.0338
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0136 1
Loa Loa (eye worm) integrin beta-2 0.0309 0.0871 0.2046
Loa Loa (eye worm) hypothetical protein 0.0278 0.0772 0.1814
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0648 0.1914 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0454 0.1315 1
Loa Loa (eye worm) histone deacetylase 11 0.0278 0.0772 0.1814
Brugia malayi hypothetical protein 0.0146 0.0368 0.0864
Leishmania major i/6 autoantigen-like protein 0.0037 0.0032 0.008
Plasmodium falciparum histone deacetylase 1 0.0648 0.1914 0.8109
Giardia lamblia Cathepsin B precursor 0.0085 0.0178 0.0868
Trichomonas vaginalis calmodulin, putative 0.0037 0.0032 0.0099
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0031 0.0013 0.0028
Leishmania major centrin, putative,caltractin, putative 0.0037 0.0032 0.008
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0085 0.0178 0.0704
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0136 0.0881
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0066 0.0226
Echinococcus multilocularis histone deacetylase 1 0.0648 0.1914 0.1914
Plasmodium falciparum serine repeat antigen 1 0.0085 0.0178 0.0704
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0201 0.0538 0.139
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0037 0.0032 0.0099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Plasmodium falciparum serine repeat antigen 4 0.0085 0.0178 0.0704
Loa Loa (eye worm) hypothetical protein 0.0393 0.1129 0.2651
Toxoplasma gondii histone deacetylase HDAC1 0.0792 0.2358 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0054 0.0118
Echinococcus multilocularis cathepsin L cysteine protease 0.0298 0.0835 0.0835
Trypanosoma cruzi cysteine peptidase, putative 0.0087 0.0184 0.0453
Trichomonas vaginalis calpain, putative 0.0061 0.0104 0.0479
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0085 0.0178 0.0868
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0031 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0298 0.0835 0.4325
Schistosoma mansoni brca1-associated protein (brap2) 0.0031 0.0013 0.0028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0054 0.0118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0171 0.0444 0.184
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0085 0.0178 0.0385
Loa Loa (eye worm) hypothetical protein 0.0146 0.0368 0.0864
Schistosoma mansoni hypothetical protein 0.0037 0.0032 0.0069
Schistosoma mansoni cathepsin B (C01 family) 0.0085 0.0178 0.0385
Leishmania major protein kinase, putative 0.0037 0.0032 0.008
Echinococcus granulosus neuronal calcium sensor 0.0037 0.0032 0.0075
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0085 0.0178 0.0868
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0038 0.0035 0.0057
Schistosoma mansoni hypothetical protein 0.0125 0.0301 0.0651
Brugia malayi Papain family cysteine protease containing protein 0.0085 0.0178 0.0418
Entamoeba histolytica grainin, putative 0.0038 0.0035 0.0114
Echinococcus granulosus cathepsin L cysteine proteinase 0.0298 0.0835 0.1962
Schistosoma mansoni calpain C (C02 family) 0.0201 0.0538 0.1164
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0201 0.0538 0.139
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0136 0.0526
Echinococcus granulosus cathepsin L 0.0085 0.0178 0.0418
Plasmodium falciparum replication factor C subunit 1, putative 0.004 0.004 0.0114
Trypanosoma cruzi cysteine peptidase, putative 0.0298 0.0835 0.2178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0298 0.0835 0.4325
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0076 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0085 0.0178 0.0868
Entamoeba histolytica calmodulin, putative 0.0037 0.0032 0.0099
Echinococcus multilocularis programmed cell death protein 0.0037 0.0032 0.0032
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0037 0.0032 0.008
Trypanosoma brucei centrin-3 0.0037 0.0032 0.008
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Echinococcus granulosus integrin alpha 3 0.0116 0.0274 0.0644
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Trichomonas vaginalis calcium binding protein, putative 0.0037 0.0032 0.0099
Trypanosoma brucei Calpain-like protein 1.1 0.0061 0.0104 0.0389
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0571 0.1677 0.3627
Entamoeba histolytica histone deacetylase, putative 0.0648 0.1914 1
Schistosoma mansoni integrin alpha-ps 0.0068 0.0126 0.0273
Trichomonas vaginalis calmodulin, putative 0.0037 0.0032 0.0099
Entamoeba histolytica grainin 2 0.0037 0.0032 0.0099
Trichomonas vaginalis calmodulin-2, putative 0.0037 0.0032 0.0099
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0278 0.0653
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0085 0.0178 0.0704
Trypanosoma brucei histone deacetylase 1 0.0648 0.1914 0.8109
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0136 0.0295
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0172 0.0403
Loa Loa (eye worm) hypothetical protein 0.0648 0.1914 0.4497
Echinococcus multilocularis cysteine protease 0.0298 0.0835 0.0835
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0037 0.0032 0.005
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0085 0.0178 0.0868
Trichomonas vaginalis calmodulin, putative 0.0037 0.0032 0.0099
Giardia lamblia Cathepsin B precursor 0.0085 0.0178 0.0868
Brugia malayi calpain 5 0.0061 0.0104 0.0245
Leishmania major cathepsin L-like protease 0.0298 0.0835 0.3507
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0029 0.0047
Plasmodium vivax vivapain-2 0.0298 0.0835 0.3507
Trypanosoma cruzi histone deacetylase, putative 0.0278 0.0772 0.2011
Onchocerca volvulus 0.0052 0.0076 0.0809
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0514 0.1112
Trichomonas vaginalis conserved hypothetical protein 0.004 0.004 0.0141
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Echinococcus granulosus histone deacetylase 3 0.0648 0.1914 0.4497
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0287 0.0803 0.1886
Brugia malayi histone deacetylase 3 (HD3) 0.0648 0.1914 0.4497
Echinococcus multilocularis centrin 2 0.0037 0.0032 0.0032
Trichomonas vaginalis calpain, putative 0.0061 0.0104 0.0479
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.004 0.0141
Brugia malayi Cathepsin L-like precursor 0.0298 0.0835 0.1962
Trypanosoma cruzi calmodulin, putative 0.0037 0.0032 0.005
Toxoplasma gondii preprocathepsin c precursor, putative 0.0085 0.0178 0.0704
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0052 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0085 0.0178 0.0868
Brugia malayi Kelch motif family protein 0.0047 0.0062 0.0147
Loa Loa (eye worm) hypothetical protein 0.0114 0.027 0.0633
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0066 0.0337
Schistosoma mansoni reticulocalbin 0.0038 0.0035 0.0075
Brugia malayi Pax transcription activation domain interacting protein 0.004 0.004 0.0094
Echinococcus multilocularis histone deacetylase 7 0.0792 0.2358 0.2358
Brugia malayi cathepsin L-like cysteine proteinase 0.0085 0.0178 0.0418
Echinococcus granulosus calpain A 0.0572 0.1679 0.3946
Onchocerca volvulus 0.0298 0.0835 0.8867
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0061 0.0104 0.0241
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1257 0.3789 0.8197
Brugia malayi calpain family protein 1 0.0534 0.1562 0.3671
Giardia lamblia Encystation-specific protease 0.0085 0.0178 0.0868
Echinococcus multilocularis cathepsin b 0.1257 0.3789 0.3789
Giardia lamblia Cathepsin B precursor 0.0085 0.0178 0.0868
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0085 0.0178 0.0704
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0201 0.0538 0.139
Brugia malayi Histone deacetylase family protein 0.0792 0.2358 0.5539
Toxoplasma gondii cathepsin B 0.0447 0.1295 0.5467
Onchocerca volvulus 0.0298 0.0835 0.8867
Trypanosoma cruzi major cysteine proteinase, putative 0.0085 0.0178 0.0437
Leishmania major histone deacetylase, putative 0.0648 0.1914 0.8109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0298 0.0835 0.4325
Loa Loa (eye worm) hypothetical protein 0.0515 0.1503 0.3531
Echinococcus multilocularis calpain 5 0.0201 0.0538 0.0538
Trypanosoma cruzi histone deacetylase, putative 0.0792 0.2358 0.6209
Giardia lamblia Cysteine protease 0.0085 0.0178 0.0868
Echinococcus multilocularis calpain A 0.0572 0.1679 0.1679
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0032 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Trichomonas vaginalis calcineurin B subunit, putative 0.0038 0.0035 0.0114
Brugia malayi Papain family cysteine protease containing protein 0.0085 0.0178 0.0418
Entamoeba histolytica calmodulin, putative 0.0037 0.0032 0.0099
Trypanosoma cruzi centrin, putative 0.0037 0.0032 0.005
Trichomonas vaginalis centrin, putative 0.0037 0.0032 0.0099
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0298 0.0835 0.3507
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0129 0.0315 0.0741
Trichomonas vaginalis histone deacetylase, putative 0.0648 0.1914 1
Echinococcus granulosus cathepsin l1 0.0298 0.0835 0.1962
Brugia malayi hypothetical protein 0.004 0.004 0.0094
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0085 0.0178 0.0385
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1257 0.3789 1
Toxoplasma gondii troponin c, isotype gamma, putative 0.0037 0.0032 0.008
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0201 0.0538 0.2239
Trypanosoma cruzi cysteine peptidase, putative 0.0298 0.0835 0.2178
Loa Loa (eye worm) hypothetical protein 0.0474 0.1376 0.3233
Brugia malayi TAR-binding protein 0.0194 0.0514 0.1208
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0172 0.0371
Brugia malayi CHE-14 protein 0.0129 0.0315 0.0741
Schistosoma mansoni histone deacetylase 1 2 3 0.0278 0.0772 0.1671
Loa Loa (eye worm) hypothetical protein 0.1257 0.3789 0.8902
Brugia malayi beta-lactamase family protein 0.0071 0.0136 0.032
Plasmodium vivax serine-repeat antigen (SERA) 0.0085 0.0178 0.0704
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0037 0.0032 0.005
Toxoplasma gondii histone deacetylase HDAC2 0.0648 0.1914 0.8109
Trypanosoma cruzi calmodulin, putative 0.0037 0.0032 0.005
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0136 0.0136
Brugia malayi Papain family cysteine protease containing protein 0.0085 0.0178 0.0418
Echinococcus multilocularis histone deacetylase 6 0.0823 0.2453 0.2453
Trypanosoma brucei hypothetical protein 0.0061 0.0104 0.0389
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0211 0.0569 0.1472
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.004 0.0114
Plasmodium vivax histone deacetylase, putative 0.0278 0.0772 0.3238
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0104 0.0479
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0031 0.0013 0.0031
Loa Loa (eye worm) hypothetical protein 0.0083 0.0174 0.041
Echinococcus multilocularis nibrin 0.004 0.004 0.004
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Brugia malayi cathepsin Z-like cysteine proteinase 0.0085 0.0178 0.0418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0027 0.0063
Toxoplasma gondii histone deacetylase HDAC3 0.0648 0.1914 0.8109
Echinococcus granulosus nibrin 0.004 0.004 0.0094
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0031 0.0013 0.0031
Echinococcus granulosus geminin 0.0497 0.1447 0.3399
Trypanosoma cruzi cysteine protease, putative 0.0171 0.0444 0.1143
Mycobacterium tuberculosis Conserved protein 0.0071 0.0136 0.0881
Onchocerca volvulus 0.0071 0.0136 0.1447
Onchocerca volvulus 0.0298 0.0835 0.8867
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0447 0.1295 0.2801
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0085 0.0178 0.0868
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0085 0.0178 0.0868
Leishmania major calmodulin-like protein 0.0037 0.0032 0.008
Entamoeba histolytica hypothetical protein 0.0036 0.0028 0.0076
Loa Loa (eye worm) hypothetical protein 0.0085 0.0178 0.0418
Mycobacterium tuberculosis Conserved protein 0.0071 0.0136 0.0881
Echinococcus multilocularis cathepsin L 0.0171 0.0444 0.0444
Loa Loa (eye worm) histone deacetylase 1 0.0648 0.1914 0.4497
Echinococcus granulosus histone deacetylase 8 0.0278 0.0772 0.1814
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0094
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0085 0.0178 0.0868
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Entamoeba histolytica hypothetical protein 0.0036 0.0028 0.0076
Echinococcus granulosus cathepsin b 0.1257 0.3789 0.8902
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0067
Onchocerca volvulus 0.0298 0.0835 0.8867
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0514 0.1112
Schistosoma mansoni topbp1 0.004 0.004 0.0086
Schistosoma mansoni cathepsin F (C01 family) 0.0298 0.0835 0.1807
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Leishmania major hypothetical protein, conserved 0.0071 0.0136 0.0526
Mycobacterium ulcerans lipase LipD 0.0071 0.0136 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0241
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.004 0.0071
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0038 0.0035 0.0075
Loa Loa (eye worm) histone deacetylase 3 0.0648 0.1914 0.4497
Trichomonas vaginalis histone deacetylase, putative 0.0648 0.1914 1
Onchocerca volvulus 0.0037 0.0032 0.0338
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0298 0.0835 0.4325
Trypanosoma brucei protein I/6 0.0037 0.0032 0.008
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0067
Trypanosoma brucei Component of motile flagella 41 0.0037 0.0032 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Entamoeba histolytica hypothetical protein, conserved 0.0038 0.0035 0.0114
Leishmania major cathepsin L-like protease 0.0298 0.0835 0.3507
Toxoplasma gondii centrin 0.0037 0.0032 0.008
Trichomonas vaginalis calcineurin B subunit, putative 0.0037 0.0032 0.0099
Brugia malayi hypothetical protein 0.0047 0.0062 0.0147
Schistosoma mansoni cathepsin s 0.0087 0.0184 0.0398
Trypanosoma brucei histone deacetylase 4 0.0792 0.2358 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0301 0.0845 0.4374
Schistosoma mansoni calmodulin 0.0037 0.0032 0.0069
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0052 0.0167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0085 0.0178 0.0868
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0298 0.0835 0.0835
Trichomonas vaginalis calcium binding protein, putative 0.0037 0.0032 0.0099
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0104 0.0241
Trypanosoma brucei histone deacetylase 2 0.0278 0.0772 0.3238
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0032 0.0099
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0178 0.0868
Brugia malayi MH2 domain containing protein 0.0117 0.0278 0.0653
Entamoeba histolytica calcium binding family protein 0.0037 0.0032 0.0099
Schistosoma mansoni histone deacetylase 4 5 0.0792 0.2358 0.51
Trypanosoma cruzi calmodulin, putative 0.0037 0.0032 0.005
Toxoplasma gondii ATPase, AAA family protein 0.004 0.004 0.0114
Trypanosoma cruzi histone deacetylase 1, putative 0.0648 0.1914 0.5035
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0066 0.0155
Schistosoma mansoni histone deacetylase 4 5 0.0792 0.2358 0.51
Loa Loa (eye worm) programmed cell death protein 6 0.0038 0.0035 0.0081
Brugia malayi calpain family protein 1 0.0534 0.1562 0.3671
Giardia lamblia Cathepsin L-like protease 0.0085 0.0178 0.0868
Giardia lamblia Cathepsin L precursor 0.0085 0.0178 0.0868
Loa Loa (eye worm) hypothetical protein 0.0087 0.0184 0.0432
Echinococcus granulosus centrin 2 0.0037 0.0032 0.0075
Leishmania major hypothetical protein, unknown function 0.0061 0.0104 0.0389
Schistosoma mansoni neuronal calcium sensor 0.0037 0.0032 0.0069
Echinococcus granulosus calcium uptake protein 1 0.0038 0.0035 0.0081
Brugia malayi histone deacetylase 1 (HD1) 0.0648 0.1914 0.4497
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0514 0.1112
Leishmania major hypothetical protein, conserved 0.0037 0.0032 0.008
Loa Loa (eye worm) hypothetical protein 0.0298 0.0835 0.1962
Plasmodium vivax histone deacetylase 1, putative 0.0648 0.1914 0.8109
Schistosoma mansoni ef hand domain family member A2 0.0037 0.0032 0.0069
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0298 0.0835 0.1962
Loa Loa (eye worm) hypothetical protein 0.0333 0.0942 0.2213
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0066 0.0155
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0104 0.0479
Giardia lamblia Replication factor C, subunit 1 0.004 0.004 0.0141
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0085 0.0178 0.0385
Loa Loa (eye worm) hypothetical protein 0.0061 0.0104 0.0245
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0085 0.0178 0.0868
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0029 0.0066
Entamoeba histolytica protein kinase, putative 0.0141 0.0352 0.1781
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0085 0.0178 0.0704
Loa Loa (eye worm) hypothetical protein 0.0211 0.0569 0.1336
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.0315 0.159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0171 0.0444 0.2269
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0136 0.0649
Loa Loa (eye worm) hypothetical protein 0.1409 0.4257 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0136 0.0881
Loa Loa (eye worm) hypothetical protein 0.0047 0.0062 0.0147
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0066 0.2718
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0037 0.0032 0.0032
Leishmania major calcineurin B subunit, putative 0.0037 0.0032 0.008
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0085 0.0178 0.0418
Trypanosoma cruzi cruzipain precursor, putative 0.0298 0.0835 0.2178
Entamoeba histolytica cysteine proteinase, putative 0.0211 0.0569 0.2923
Giardia lamblia Hypothetical protein 0.0085 0.0178 0.0868
Trypanosoma cruzi cysteine proteinase, putative 0.0171 0.0444 0.1143
Echinococcus granulosus histone deacetylase 6 0.0823 0.2453 0.5763
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Echinococcus multilocularis tumor protein p63 0.0352 0.1001 0.1001
Plasmodium vivax histone deacetylase, putative 0.0792 0.2358 1
Trypanosoma brucei Calpain-like protein 2 0.0061 0.0104 0.0389
Schistosoma mansoni calpain (C02 family) 0.0201 0.0538 0.1164
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0306 0.0859 0.1858
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0298 0.0835 0.3507
Echinococcus granulosus cathepsin b 0.1257 0.3789 0.8902
Toxoplasma gondii calcium-dependent protein kinase 0.0038 0.0035 0.0092
Trypanosoma cruzi centrin-3 0.0037 0.0032 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Loa Loa (eye worm) hypothetical protein 0.0085 0.0178 0.0418
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0066 0.3481
Echinococcus granulosus histone deacetylase 7 0.0792 0.2358 0.5539
Echinococcus multilocularis integrin alpha ps 0.0032 0.0018 0.0018
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0571 0.1677 0.1677
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0037 0.0032 0.008
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0034 0.0091
Brugia malayi Cathepsin L-like cysteine proteinase 0.0211 0.0569 0.1336
Entamoeba histolytica cysteine protease, putative 0.0085 0.0178 0.0868
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0034 0.0113
Entamoeba histolytica calcium-binding protein, putative 0.0037 0.0032 0.0099
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Giardia lamblia Cathepsin B precursor 0.0085 0.0178 0.0868
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.004 0.0071
Schistosoma mansoni Mername-AA248 (C02 family) 0.0201 0.0538 0.1164
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0136 1
Echinococcus granulosus histone deacetylase 0.0792 0.2358 0.5539
Loa Loa (eye worm) hypothetical protein 0.0082 0.0172 0.0403
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0298 0.0835 0.4325
Entamoeba histolytica cysteine protease, putative 0.0085 0.0178 0.0868
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Echinococcus multilocularis calbindin 32 0.0038 0.0035 0.0035
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0298 0.0835 0.0835
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0178 0.0868
Brugia malayi Histone deacetylase 1 0.0648 0.1914 0.4497
Trypanosoma cruzi major cysteine proteinase, putative 0.0085 0.0178 0.0437
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Entamoeba histolytica cysteine proteinase, putative 0.0171 0.0444 0.2269
Trypanosoma brucei caltractin, putative 0.0037 0.0032 0.008
Entamoeba histolytica cysteine proteinase, putative 0.0171 0.0444 0.2269
Loa Loa (eye worm) hypothetical protein 0.0052 0.0077 0.0182
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0571 0.1677 0.3939
Brugia malayi topoisomerase 0.004 0.004 0.0094
Loa Loa (eye worm) fibroinase 0.0298 0.0835 0.1962
Schistosoma mansoni hypothetical protein 0.0125 0.0301 0.0651
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0136 0.0649
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0085 0.0178 0.0868
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0085 0.0178 0.0385
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0085 0.0178 0.0868
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0063
Brugia malayi hypothetical protein 0.004 0.004 0.0094
Echinococcus granulosus EF hand domain containing family member A2 0.0037 0.0032 0.0075
Echinococcus multilocularis calpain family protein 1, d 0.0393 0.1129 0.1129
Trypanosoma cruzi histone deacetylase 1, putative 0.0648 0.1914 0.5035
Onchocerca volvulus 0.004 0.004 0.0423
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1257 0.3789 0.8197
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0171 0.0444 0.0962
Onchocerca volvulus 0.0333 0.0942 1
Toxoplasma gondii calmodulin CAM1 0.0038 0.0035 0.0092
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0094
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0201 0.0538 0.2239
Toxoplasma gondii cathepsin CPC1 0.0085 0.0178 0.0704
Echinococcus multilocularis cathepsin L cysteine protease 0.0298 0.0835 0.0835
Echinococcus multilocularis BRCA1 associated protein 0.0031 0.0013 0.0013
Brugia malayi DKFZp564C0469 protein 0.004 0.004 0.0094
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0104 0.0241
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0031 0.0013 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Schistosoma mansoni hypothetical protein 0.0125 0.0301 0.0651
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0054 0.0128
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0067
Schistosoma mansoni hypothetical protein 0.0061 0.0104 0.0225
Leishmania major centrin, putative 0.0037 0.0032 0.008
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0035 0.0092
Giardia lamblia Cathepsin L-like protease 0.0085 0.0178 0.0868
Leishmania major cathepsin L-like protease 0.0298 0.0835 0.3507
Trypanosoma cruzi I/6 autoantigen, putative 0.0037 0.0032 0.005
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0094
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0136 0.0327
Plasmodium vivax centrin-1, putative 0.0037 0.0032 0.008
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0571 0.1677 0.3627
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0648 0.1914 1
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0136 0.0881
Plasmodium vivax histone deacetylase 2, putative 0.0792 0.2358 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0054 0.0128
Plasmodium vivax unspecified product 0.0087 0.0184 0.073
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0339 0.0796
Echinococcus granulosus EF HAND 1 calcium binding site 0.0037 0.0032 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0085 0.0178 0.0868
Toxoplasma gondii cathepsin CPL 0.0298 0.0835 0.3507
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0066 0.0279
Echinococcus granulosus calpain A 0.0201 0.0538 0.1264
Echinococcus multilocularis protein dispatched 1 0.0147 0.0372 0.0372
Brugia malayi Cathepsin L-like precursor 0.0087 0.0184 0.0432
Loa Loa (eye worm) RNA binding protein 0.0194 0.0514 0.1208
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0114 0.027 0.0633
Trypanosoma cruzi kinesin, putative 0.0141 0.0352 0.0897
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0171 0.0444 0.0962
Echinococcus granulosus integrin alpha ps 0.0032 0.0018 0.0041
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Echinococcus granulosus replication factor c subunit 1 0.004 0.004 0.0094
Brugia malayi cathepsin L precursor 0.0085 0.0178 0.0418
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0094
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.0358 0.0358
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0061 0.0104 0.0389
Brugia malayi hypothetical protein 0.1409 0.4257 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0447 0.1295 0.3395
Trypanosoma cruzi cruzipain precursor, putative 0.0087 0.0184 0.0453
Plasmodium falciparum serine repeat antigen 7 0.0085 0.0178 0.0704
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.004 0.004 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0211 0.0569 0.2923
Plasmodium falciparum serine repeat antigen 6 0.0085 0.0178 0.0704
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0031 0.0013 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0032 0.0099
Schistosoma mansoni hypothetical protein 0.0125 0.0301 0.0651
Brugia malayi programmed cell death protein 6 0.0037 0.0032 0.0075
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Entamoeba histolytica hypothetical protein 0.0036 0.0028 0.0076
Leishmania major cathepsin L-like protease 0.0298 0.0835 0.3507
Onchocerca volvulus 0.0082 0.0172 0.1822
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0037 0.0032 0.0099
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0085 0.0178 0.0704
Echinococcus multilocularis calmodulin 0.0037 0.0032 0.0032
Brugia malayi Cathepsin L-like precursor 0.0298 0.0835 0.1962
Leishmania major hypothetical protein, conserved 0.0061 0.0104 0.0389
Echinococcus granulosus histone deacetylase 6 0.0792 0.2358 0.5539
Entamoeba histolytica cysteine proteinase, putative 0.0171 0.0444 0.2269
Echinococcus multilocularis protein patched 0.0129 0.0315 0.0315
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0194 0.0514 0.1208
Brugia malayi EF hand family protein 0.0038 0.0035 0.0081
Loa Loa (eye worm) cathepsin B 0.0447 0.1295 0.3042
Loa Loa (eye worm) hypothetical protein 0.0085 0.0178 0.0418
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0077 0.0182
Trichomonas vaginalis histone deacetylase, putative 0.0648 0.1914 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0085 0.0178 0.0868
Loa Loa (eye worm) ctsf protein 0.0298 0.0835 0.1962
Leishmania major cathepsin L-like protease 0.0298 0.0835 0.3507
Schistosoma mansoni calpain-7 (C02 family) 0.0201 0.0538 0.1164
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0085 0.0178 0.0868
Schistosoma mansoni neuronal calcium sensor 0.0037 0.0032 0.0069
Echinococcus granulosus tar DNA binding protein 0.0194 0.0514 0.1208
Loa Loa (eye worm) hypothetical protein 0.0071 0.0136 0.032
Mycobacterium ulcerans hypothetical protein 0.0048 0.0066 0.3481
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0241
Schistosoma mansoni hypothetical protein 0.0497 0.1447 0.313
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0648 0.1914 1
Trypanosoma brucei histone deacetylase 3 0.0792 0.2358 1
Schistosoma mansoni topbp1 0.004 0.004 0.0086
Giardia lamblia Cathepsin B precursor 0.0447 0.1295 0.6742
Schistosoma mansoni histone deacetylase 0.0648 0.1914 0.4141
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.0134
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0037 0.0032 0.0069
Trypanosoma cruzi histone deacetylase, putative 0.0792 0.2358 0.6209
Trypanosoma brucei calpain-like protein, putative 0.0201 0.0538 0.2239
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Trichomonas vaginalis centrin, putative 0.0037 0.0032 0.0099
Brugia malayi RNA binding protein 0.0194 0.0514 0.1208
Plasmodium falciparum serine repeat antigen 9 0.0085 0.0178 0.0704
Trichomonas vaginalis histone deacetylase, putative 0.0648 0.1914 1
Echinococcus granulosus cathepsin L cysteine protease 0.0171 0.0444 0.1044
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0031 0.0013 0.0031
Trypanosoma brucei calpain-like protein, putative 0.0201 0.0538 0.2239
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0031 0.0013 0.0013
Schistosoma mansoni DNA ligase IV 0.004 0.004 0.0086
Loa Loa (eye worm) beta-lactamase 0.0071 0.0136 0.032
Onchocerca volvulus 0.0298 0.0835 0.8867
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0136 0.0649
Echinococcus multilocularis hypothetical protein 0.0201 0.0538 0.0538
Schistosoma mansoni integrin alpha 0.0151 0.0383 0.0828
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0136 0.032
Echinococcus multilocularis programmed cell death protein 0.0037 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0301 0.0845 0.1984
Onchocerca volvulus 0.0038 0.0035 0.0368
Loa Loa (eye worm) hypothetical protein 0.0087 0.0184 0.0432
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0085 0.0178 0.0868
Leishmania major calmodulin-like protein 0.0037 0.0032 0.008
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0037 0.0032 0.0032
Schistosoma mansoni mitochondrial solute carrier 0.0037 0.0032 0.0069
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0104 0.0241
Entamoeba histolytica hypothetical protein 0.0085 0.0178 0.0868
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0447 0.1295 0.5467
Plasmodium vivax unspecified product 0.0085 0.0178 0.0704
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1257 0.3789 0.8197
Echinococcus multilocularis histone deacetylase 6 0.0792 0.2358 0.2358
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0085 0.0178 0.0704
Echinococcus granulosus Niemann Pick C1 protein 0.0301 0.0845 0.1984
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0066 0.3481
Brugia malayi Cathepsin L-like precursor 0.0298 0.0835 0.1962
Loa Loa (eye worm) hypothetical protein 0.0052 0.0076 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0085 0.0178 0.0868
Onchocerca volvulus Cathepsin L homolog 0.0298 0.0835 0.8867
Trypanosoma brucei kinesin, putative 0.0141 0.0352 0.1444
Loa Loa (eye worm) hypothetical protein 0.0048 0.0066 0.0155
Brugia malayi PHD-finger family protein 0.0028 0.0003 0.0008
Echinococcus granulosus calpain 0.0201 0.0538 0.1264
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0201 0.0538 0.139
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0136 0.032
Schistosoma mansoni survival motor neuron protein 0.0287 0.0803 0.1736
Onchocerca volvulus 0.0287 0.0803 0.852
Trichomonas vaginalis calpain, putative 0.0061 0.0104 0.0479
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0031 0.0013 0.0031
Brugia malayi Cathepsin L-like precursor 0.0298 0.0835 0.1962
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0534 0.1562 0.338
Leishmania major calmodulin, putative 0.0037 0.0032 0.008
Echinococcus granulosus cathepsin l1 0.0211 0.0569 0.1336
Echinococcus multilocularis replication factor c subunit 1 0.004 0.004 0.004
Trypanosoma cruzi cysteine peptidase, putative 0.0298 0.0835 0.2178
Trichomonas vaginalis calmodulin, putative 0.0037 0.0032 0.0099
Trypanosoma cruzi cysteine peptidase, putative 0.0171 0.0444 0.1143
Plasmodium vivax vivapain-2 0.0298 0.0835 0.3507
Echinococcus multilocularis integrin beta 2 0.0229 0.0624 0.0624
Trichomonas vaginalis calcium binding protein, putative 0.0037 0.0032 0.0099
Schistosoma mansoni cathepsin S (C01 family) 0.0085 0.0178 0.0385
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0087 0.0184 0.0432
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0061 0.0104 0.0241
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0066 0.3481
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0037 0.0032 0.005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0298 0.0835 0.4325
Trichomonas vaginalis calmodulin, putative 0.0037 0.0032 0.0099
Echinococcus multilocularis cathepsin L 0.0085 0.0178 0.0178
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0077 0.0182
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.0773 0.1672
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0104 0.0241
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0136 0.0526
Echinococcus granulosus survival motor neuron protein 1 0.1409 0.4257 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0171 0.0444 0.184
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0201 0.0538 0.139
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0104 0.0479
Plasmodium falciparum serine repeat antigen 2 0.0085 0.0178 0.0704
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.4623 1
Entamoeba histolytica hypothetical protein 0.0036 0.0028 0.0076
Schistosoma mansoni centrin 0.0037 0.0032 0.0069
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0241
Onchocerca volvulus Cathepsin L homolog 0.0298 0.0835 0.8867
Schistosoma mansoni hypothetical protein 0.0287 0.0803 0.1736
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0028 0.0065
Loa Loa (eye worm) EF hand family protein 0.0037 0.0032 0.0075
Schistosoma mansoni hypothetical protein 0.0036 0.0028 0.006
Plasmodium falciparum centrin-1 0.0037 0.0032 0.008
Brugia malayi Papain family cysteine protease containing protein 0.0171 0.0444 0.1044
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0085 0.0178 0.0704
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0029 0.0066
Schistosoma mansoni neuronal calcium sensor 0.0037 0.0032 0.0069
Trypanosoma brucei histone deacetylase, putative 0.0792 0.2358 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0301 0.0845 0.1984
Plasmodium falciparum serine repeat antigen 3 0.0085 0.0178 0.0704
Schistosoma mansoni calpain-2 (C02 family) 0.0061 0.0104 0.0225
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0066 0.3481
Echinococcus granulosus neurocalcin 0.0037 0.0032 0.0075
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0061 0.0104 0.0389
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0241
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0066 0.3481
Echinococcus multilocularis cathepsin b 0.1257 0.3789 0.3789
Mycobacterium ulcerans hypothetical protein 0.0071 0.0136 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0298 0.0835 0.4325
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0037 0.0032 0.008
Entamoeba histolytica cysteine proteinase, putative 0.0298 0.0835 0.4325
Schistosoma mansoni patched 1 0.0129 0.0315 0.0682
Giardia lamblia Cathepsin B precursor 0.0447 0.1295 0.6742
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0037 0.0032 0.0099
Toxoplasma gondii histone deacetylase HDAC4 0.0278 0.0772 0.3238
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0028 0.006
Entamoeba histolytica cysteine protease, putative 0.0085 0.0178 0.0868
Plasmodium falciparum cysteine proteinase falcipain 3 0.0298 0.0835 0.3507
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0201 0.0538 0.139
Plasmodium falciparum serine repeat antigen 5 0.0085 0.0178 0.0704
Loa Loa (eye worm) calpain 5 0.0141 0.0352 0.0826
Trichomonas vaginalis calcium binding proteins, putative 0.0037 0.0032 0.0099
Trypanosoma brucei calpain-like protein, putative 0.0201 0.0538 0.2239
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0031 0.0013 0.0138
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0447 0.1295 0.6742
Trichomonas vaginalis conserved hypothetical protein 0.004 0.004 0.0141
Schistosoma mansoni cathepsin F (C01 family) 0.0211 0.0569 0.123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Giardia lamblia Cathepsin B precursor 0.0085 0.0178 0.0868
Schistosoma mansoni centrin-related 0.0037 0.0032 0.0069
Trypanosoma brucei antigen, putative 0.0201 0.0538 0.2239
Trichomonas vaginalis esterase, putative 0.0071 0.0136 0.0649
Schistosoma mansoni histone deacetylase hda2 0.0823 0.2453 0.5307
Loa Loa (eye worm) calmodulin-like protein 0.0037 0.0032 0.0075
Loa Loa (eye worm) hypothetical protein 0.0037 0.0032 0.0075
Entamoeba histolytica cysteine proteinase, putative 0.0298 0.0835 0.4325
Echinococcus multilocularis neuronal calcium sensor 0.0037 0.0032 0.0032
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0201 0.0538 0.2239
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0085 0.0178 0.0704
Plasmodium falciparum histone deacetylase 2 0.0792 0.2358 1
Chlamydia trachomatis DNA ligase 0.004 0.004 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.004 0.0141
Plasmodium vivax serine-repeat antigen (SERA) 0.0085 0.0178 0.0704
Brugia malayi EF hand family protein 0.0037 0.0032 0.0075
Schistosoma mansoni hypothetical protein 0.0037 0.0032 0.0069
Echinococcus granulosus cathepsin L 0.0171 0.0444 0.1044
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0067
Echinococcus multilocularis histone deacetylase 8 0.0278 0.0772 0.0772
Mycobacterium tuberculosis Conserved protein 0.0071 0.0136 0.0881
Loa Loa (eye worm) hypothetical protein 0.0211 0.0569 0.1336
Loa Loa (eye worm) calpain 0.0201 0.0538 0.1264
Loa Loa (eye worm) calpain family protein 1 0.0393 0.1129 0.2651
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0026 0.0026
Brugia malayi fibroinase precursor 0.0085 0.0178 0.0418
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0066 0.3481
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0047 0.0062 0.0147
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0085 0.0178 0.0385
Loa Loa (eye worm) hypothetical protein 0.0071 0.0136 0.032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Loa Loa (eye worm) TAR-binding protein 0.0194 0.0514 0.1208
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Brugia malayi BRCA1-associated protein 2 containing protein 0.0031 0.0013 0.0031
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0104 0.0479
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0298 0.0835 0.4325
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0037 0.0032 0.005
Echinococcus granulosus microtubule associated protein 2 0.1403 0.4239 0.9959
Giardia lamblia Cysteine protease 0.0085 0.0178 0.0868
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.004 0.004 0.0094
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0136 1
Schistosoma mansoni calmodulin 0.0037 0.0032 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Plasmodium vivax replication factor C subunit 1, putative 0.004 0.004 0.0114
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0108 0.0108
Entamoeba histolytica cysteine protease, putative 0.0298 0.0835 0.4325
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Trypanosoma cruzi cysteine proteinase, putative 0.0171 0.0444 0.1143
Loa Loa (eye worm) cysteine protease 0.0298 0.0835 0.1962
Echinococcus multilocularis expressed conserved protein 0.0283 0.0788 0.0788
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0054 0.0128
Toxoplasma gondii histone deacetylase HDAC5 0.0278 0.0772 0.3238
Echinococcus granulosus cysteine protease 0.0171 0.0444 0.1044
Plasmodium falciparum calpain 0.0061 0.0104 0.0389
Trypanosoma brucei calmodulin, putative 0.0037 0.0032 0.008
Trypanosoma brucei cysteine peptidase, putative 0.0061 0.0104 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Echinococcus multilocularis histone deacetylase 3 0.0648 0.1914 0.1914
Echinococcus multilocularis sterol regulatory element binding protein 0.0129 0.0315 0.0315
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0201 0.0538 0.139
Echinococcus granulosus tumor protein p63 0.0352 0.1001 0.2352
Schistosoma mansoni rab 0.0037 0.0032 0.0069
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0171 0.0444 0.1143
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0061 0.0104 0.0241
Brugia malayi Calmodulin-like protein 0.0037 0.0032 0.0075
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0104 0.0241
Trypanosoma cruzi histone deacetylase, putative 0.0278 0.0772 0.2011
Schistosoma mansoni microtubule-associated protein tau 0.1403 0.4239 0.917
Echinococcus multilocularis EF hand domain containing family member A2 0.0038 0.0035 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Plasmodium vivax vivapain-3 0.0171 0.0444 0.184
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0136 0.0295
Giardia lamblia Hypothetical protein 0.0085 0.0178 0.0868
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0241
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.004 0.0141
Onchocerca volvulus 0.0085 0.0178 0.189
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0136 0.0327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Echinococcus granulosus histone deacetylase 6 0.0792 0.2358 0.5539
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0278 0.0653
Schistosoma mansoni histone deacetylase 0.0648 0.1914 0.4141
Trichomonas vaginalis hypothetical protein 0.0061 0.0104 0.0479
Trypanosoma brucei Calpain-like protein 1.2 0.0061 0.0104 0.0389
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0171 0.0444 0.0962
Brugia malayi calpain 7 0.0201 0.0538 0.1264
Echinococcus multilocularis microtubule associated protein 2 0.1403 0.4239 0.4239
Onchocerca volvulus 0.0146 0.0368 0.3906
Brugia malayi calpain D 0.0061 0.0104 0.0245
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0104 0.0241
Schistosoma mansoni reticulocalbin 0.0037 0.0032 0.0069
Trichomonas vaginalis histone deacetylase, putative 0.0648 0.1914 1
Onchocerca volvulus Histone deacetylase 10 homolog 0.0278 0.0772 0.8199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0211 0.0569 0.2923
Leishmania major kinesin, putative 0.0141 0.0352 0.1444
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0085 0.0178 0.0385
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0052 0.0123
Giardia lamblia Cathepsin L precursor 0.0085 0.0178 0.0868
Loa Loa (eye worm) hypothetical protein 0.0129 0.0315 0.0741
Leishmania major histone deacetylase, putative 0.0648 0.1914 0.8109
Trypanosoma cruzi I/6 autoantigen, putative 0.0037 0.0032 0.005
Loa Loa (eye worm) hypothetical protein 0.0032 0.0018 0.0041
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0066 0.0226
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0054 0.0054
Echinococcus granulosus integrin beta 2 0.0229 0.0624 0.1465
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0087 0.0184 0.0432
Schistosoma mansoni hypothetical protein 0.0497 0.1447 0.313
Trypanosoma cruzi kinesin, putative 0.0141 0.0352 0.0897
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0136 0.0881
Giardia lamblia Cysteine protease 0.0085 0.0178 0.0868
Leishmania major calpain protease-like protein 0.0061 0.0104 0.0389
Trichomonas vaginalis conserved hypothetical protein 0.004 0.004 0.0141
Entamoeba histolytica cysteine proteinase, putative 0.0171 0.0444 0.2269
Entamoeba histolytica cysteine protease, putative 0.0085 0.0178 0.0868
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0514 0.1112
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.004 0.004 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0085 0.0178 0.0385
Plasmodium falciparum serine repeat antigen 8 0.0085 0.0178 0.0704
Trypanosoma cruzi caltractin, putative 0.0037 0.0032 0.005
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0085 0.0178 0.0704
Toxoplasma gondii EFHC1, putative 0.0037 0.0032 0.008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0066 0.0337
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0085 0.0178 0.0704
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0085 0.0178 0.0704
Brugia malayi calpain 5 0.0141 0.0352 0.0826
Echinococcus multilocularis integrin alpha ps 0.0068 0.0126 0.0126
Schistosoma mansoni integrin beta subunit 0.0182 0.0479 0.1036
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0061 0.0106 0.0395
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0031 0.0013 0.0031
Loa Loa (eye worm) hypothetical protein 0.0087 0.0184 0.0432
Onchocerca volvulus 0.0071 0.0136 0.1447
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0136 0.0881
Entamoeba histolytica cysteine proteinase 2 0.0171 0.0444 0.2269
Trypanosoma brucei calpain-like protein, putative 0.0201 0.0538 0.2239
Loa Loa (eye worm) integrin alpha pat-2 0.0233 0.0635 0.1492
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0171 0.0444 0.2269
Trichomonas vaginalis calmodulin, putative 0.0038 0.0035 0.0114
Echinococcus multilocularis integrin alpha ps 0.0068 0.0126 0.0126
Mycobacterium leprae Probable lipase LipE 0.0071 0.0136 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0085 0.0178 0.0385
Loa Loa (eye worm) hypothetical protein 0.0069 0.0131 0.0308
Echinococcus multilocularis calpain 0.0201 0.0538 0.0538
Brugia malayi hypothetical protein 0.0036 0.0028 0.0065
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.004 0.004 0.1049
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Leishmania major centrin, putative 0.0037 0.0032 0.008
Brugia malayi Papain family cysteine protease containing protein 0.0171 0.0444 0.1044
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0066 0.3481
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0054 0.0118
Trypanosoma brucei centrin, putative 0.0037 0.0032 0.008
Loa Loa (eye worm) hypothetical protein 0.0071 0.0136 0.032
Loa Loa (eye worm) hypothetical protein 0.0048 0.0066 0.0155
Schistosoma mansoni chromosome transmission fidelity factor 0.004 0.004 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0066 0.0226
Brugia malayi histone deacetylase 11 0.0278 0.0772 0.1814
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1257 0.3789 0.8197
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0136 0.0649
Plasmodium vivax vivapain-1 0.0171 0.0444 0.184
Trypanosoma brucei calpain, putative 0.0061 0.0104 0.0389
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0104 0.0479
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Schistosoma mansoni bromodomain containing protein 0.0065 0.0119 0.0258
Giardia lamblia Hypothetical protein 0.0038 0.0035 0.0114
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Leishmania major cysteine peptidase A (CPA) 0.0298 0.0835 0.3507
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0061 0.0104 0.0241
Schistosoma mansoni hypothetical protein 0.0032 0.0018 0.0038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0298 0.0835 0.4325
Loa Loa (eye worm) hypothetical protein 0.0071 0.0136 0.032
Echinococcus multilocularis neurocalcin 0.0037 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.004 0.004 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0085 0.0178 0.0868
Entamoeba histolytica hypothetical protein 0.004 0.004 0.0141
Leishmania major phospholipase c-like protein 0.0037 0.0032 0.008
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0037 0.0032 0.0075
Echinococcus multilocularis survival motor neuron protein 1 0.1409 0.4257 0.4257
Echinococcus granulosus calmodulin 0.0037 0.0032 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0085 0.0178 0.0868
Trypanosoma brucei I/6 autoantigen 0.0037 0.0032 0.008
Schistosoma mansoni neuronal calcium sensor 0.0037 0.0032 0.0069
Trypanosoma brucei Calpain-like protein CALP1.3 0.0061 0.0104 0.0389
Echinococcus multilocularis integrin alpha 3 0.0116 0.0274 0.0274
Trypanosoma brucei cysteine peptidase C (CPC) 0.0447 0.1295 0.5467
Onchocerca volvulus 0.0071 0.0136 0.1447
Brugia malayi RNA recognition motif domain containing protein 0.0194 0.0514 0.1208
Echinococcus multilocularis geminin 0.0497 0.1447 0.1447
Leishmania major histone deacetylase, putative 0.0792 0.2358 1
Loa Loa (eye worm) histone deacetylase 7A 0.0792 0.2358 0.5539
Entamoeba histolytica calpain family cysteine protease, putative 0.0061 0.0104 0.0479
Leishmania major calpain family cysteine protease-like protein 0.0061 0.0104 0.0389
Loa Loa (eye worm) hypothetical protein 0.0158 0.0405 0.0951
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0085 0.0178 0.0868
Echinococcus granulosus calbindin 32 0.0038 0.0035 0.0081
Trichomonas vaginalis calmodulin, putative 0.0037 0.0032 0.0099
Schistosoma mansoni calmodulin related calcium binding protein 0.0037 0.0032 0.0069
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0241
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0136 0.0649
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0298 0.0835 0.4325
Echinococcus multilocularis cysteine protease 0.0298 0.0835 0.0835
Echinococcus granulosus calpain 5 0.0201 0.0538 0.1264
Trypanosoma cruzi conserved protein 0.0061 0.0104 0.0241
Schistosoma mansoni histone deacetylase hda2 0.0278 0.0772 0.1671
Entamoeba histolytica cysteine protease, putative 0.0085 0.0178 0.0868
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0085 0.0178 0.0704
Trichomonas vaginalis calcium binding protein, putative 0.0037 0.0032 0.0099
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0201 0.0538 0.139
Giardia lamblia Cathepsin B precursor 0.0447 0.1295 0.6742
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0077 0.0182
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0066 0.2718
Brugia malayi cathepsin F-like cysteine proteinase 0.0085 0.0178 0.0418
Echinococcus granulosus cathepsin l cysteine peptidase 0.0298 0.0835 0.1962
Brugia malayi Integrin alpha pat-2 precursor 0.0151 0.0383 0.09
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0094
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0108 0.0255
Loa Loa (eye worm) hypothetical protein 0.0043 0.0051 0.012
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Toxoplasma gondii cathepsin CPC2 0.0085 0.0178 0.0704
Echinococcus granulosus calumenin 0.0038 0.0035 0.0081
Loa Loa (eye worm) hypothetical protein 0.0038 0.0033 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0298 0.0835 0.3507
Loa Loa (eye worm) hypothetical protein 0.0071 0.0136 0.032
Schistosoma mansoni cathepsin C 0.0085 0.0178 0.0385
Loa Loa (eye worm) histone deacetylase 0.0792 0.2358 0.5539
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0085 0.0178 0.0418
Loa Loa (eye worm) calpain family protein 1 0.0534 0.1562 0.3671
Schistosoma mansoni calpain-7 (C02 family) 0.0201 0.0538 0.1164
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0104 0.0479
Brugia malayi Integrin beta pat-3 precursor 0.0309 0.0871 0.2046
Brugia malayi Cathepsin L-like precursor 0.0298 0.0835 0.1962
Entamoeba histolytica cysteine protease, putative 0.0085 0.0178 0.0868
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Trypanosoma brucei mitochondrial calcium uptake 1 0.0037 0.0032 0.008
Giardia lamblia Cathepsin L precursor 0.0085 0.0178 0.0868
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0054 0.0054
Brugia malayi Cathepsin L-like precursor 0.0298 0.0835 0.1962
Echinococcus granulosus expressed conserved protein 0.0283 0.0788 0.1852
Loa Loa (eye worm) hypothetical protein 0.0085 0.0178 0.0418
Trypanosoma cruzi FHA domain containing protein, putative 0.004 0.004 0.0071
Trypanosoma cruzi cysteine peptidase, putative 0.0298 0.0835 0.2178
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0052 0.0167
Trypanosoma cruzi centrin, putative 0.0037 0.0032 0.005
Brugia malayi beta-lactamase family protein 0.0071 0.0136 0.032
Schistosoma mansoni cathepsin F (C01 family) 0.0298 0.0835 0.1807
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0298 0.0835 0.4325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Leishmania major cathepsin L-like protease 0.0298 0.0835 0.3507
Echinococcus multilocularis calpain 7 (C02 family) 0.0201 0.0538 0.0538
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0031 0.0013 0.0031
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0085 0.0178 0.0418
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0172 0.0172
Trichomonas vaginalis calmodulin, putative 0.0037 0.0032 0.0099
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0298 0.0835 0.1962
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.004 0.0141
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0085 0.0178 0.0704
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0085 0.0178 0.0868
Echinococcus granulosus sterol regulatory element binding protein 0.0129 0.0315 0.0741
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0136 0.032
Echinococcus granulosus Protein patched homolog 1 0.0129 0.0315 0.0741
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0298 0.0835 0.4325
Loa Loa (eye worm) hypothetical protein 0.0119 0.0283 0.0665
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0052 0.0206
Trichomonas vaginalis histone deacetylase, putative 0.0648 0.1914 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0066 0.0155
Trypanosoma brucei centrin, putative 0.0037 0.0032 0.008
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0136 0.0881
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.0358 0.0774
Plasmodium vivax unspecified product 0.0171 0.0444 0.184
Trichomonas vaginalis calmodulin, putative 0.0037 0.0032 0.0099
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0026 0.0061
Loa Loa (eye worm) hypothetical protein 0.0085 0.0178 0.0418
Toxoplasma gondii ABC1 family protein 0.0071 0.0136 0.0526
Echinococcus granulosus integrin alpha ps 0.0068 0.0126 0.0297
Loa Loa (eye worm) acetyltransferase 0.0143 0.0358 0.0841
Echinococcus granulosus Niemann Pick C1 protein 0.043 0.1242 0.2919
Echinococcus granulosus programmed cell death protein 0.0037 0.0032 0.0075
Brugia malayi beta-lactamase 0.0071 0.0136 0.032
Loa Loa (eye worm) calpain D 0.0061 0.0104 0.0245
Treponema pallidum DNA ligase (lig) 0.004 0.004 0.5
Brugia malayi Histone deacetylase family protein 0.0792 0.2358 0.5539
Brugia malayi cathepsin L-like precursor 0.0211 0.0569 0.1336
Echinococcus granulosus calpain 7 C02 family 0.0201 0.0538 0.1264
Echinococcus multilocularis Niemann Pick C1 protein 0.0301 0.0845 0.0845
Giardia lamblia Cathepsin L precursor 0.0085 0.0178 0.0868
Loa Loa (eye worm) hypothetical protein 0.0037 0.0032 0.0075
Brugia malayi cathepsin B-like cysteine proteinase 0.1257 0.3789 0.8902
Loa Loa (eye worm) hypothetical protein 0.0546 0.1598 0.3755
Onchocerca volvulus 0.0298 0.0835 0.8867
Schistosoma mansoni hypothetical protein 0.0035 0.0027 0.0058
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Echinococcus multilocularis calmodulin 0.0037 0.0032 0.0032
Trypanosoma brucei calmodulin, putative 0.0038 0.0035 0.0092
Entamoeba histolytica cysteine proteinase 1, putative 0.0171 0.0444 0.2269
Plasmodium falciparum histone deacetylase, putative 0.0792 0.2358 1
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0061 0.0104 0.0479
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0085 0.0178 0.0418
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Brugia malayi Bromodomain containing protein 0.0077 0.0155 0.0363
Leishmania major programmed cell death 6 protein-like protein 0.0037 0.0032 0.008
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0136 0.0881
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0037 0.0032 0.0099
Plasmodium falciparum cysteine proteinase falcipain 1 0.0171 0.0444 0.184
Entamoeba histolytica cysteine protease, putative 0.0171 0.0444 0.2269
Giardia lamblia Cathepsin L precursor 0.0085 0.0178 0.0868
Trichomonas vaginalis myosin light chain 1, putative 0.0037 0.0032 0.0099
Brugia malayi Papain family cysteine protease containing protein 0.0298 0.0835 0.1962
Echinococcus multilocularis EF hand domain containing family member A2 0.0037 0.0032 0.0032
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Trypanosoma cruzi histone deacetylase, putative 0.0792 0.2358 0.6209
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0085 0.0178 0.0868
Echinococcus multilocularis calcium uptake protein 1 0.0038 0.0035 0.0035
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Brugia malayi cathepsin Z-like cysteine proteinase 0.0085 0.0178 0.0418
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0085 0.0178 0.0385
Trypanosoma brucei calpain, putative 0.0061 0.0104 0.0389
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0094
Leishmania major calmodulin, putative 0.0037 0.0032 0.008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0054 0.0128
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0514 0.1112
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0201 0.0538 0.2239
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.004 0.0141
Loa Loa (eye worm) hypothetical protein 0.0211 0.0569 0.1336
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0066 0.0279
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0031 0.0013 0.0031
Brugia malayi Cathepsin L-like precursor 0.0211 0.0569 0.1336
Giardia lamblia Cathepsin L precursor 0.0085 0.0178 0.0868
Entamoeba histolytica calpain large subunit domain III containing protein 0.0141 0.0352 0.1781
Leishmania major cathepsin L-like protease 0.0298 0.0835 0.3507
Echinococcus multilocularis calumenin 0.0038 0.0035 0.0035
Brugia malayi Bromodomain containing protein 0.0041 0.0044 0.0103
Toxoplasma gondii hypothetical protein 0.0061 0.0104 0.0389
Onchocerca volvulus Cathepsin L homolog 0.0085 0.0178 0.189
Leishmania major hypothetical protein, conserved 0.0038 0.0035 0.0092
Echinococcus granulosus EF hand domain containing family member A2 0.0038 0.0035 0.0081
Mycobacterium ulcerans beta-lactamase 0.0071 0.0136 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0052 0.0167
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0241
Toxoplasma gondii centrin, putative 0.0037 0.0032 0.008
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0031 0.0013 0.0031
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0066 0.0279
Brugia malayi calcium-binding protein 0.0037 0.0032 0.0075
Echinococcus multilocularis Niemann Pick C1 protein 0.043 0.1242 0.1242
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0031 0.0013 0.0013
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0037 0.0032 0.005
Loa Loa (eye worm) hypothetical protein 0.0085 0.0178 0.0418
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0034 0.0113
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0201 0.0538 0.2239
Echinococcus multilocularis histone deacetylase 6 0.0792 0.2358 0.2358
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0104 0.0389
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0201 0.0538 0.139
Brugia malayi cathepsin F-like cysteine proteinase 0.0087 0.0184 0.0432
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0028 0.0028
Onchocerca volvulus 0.0211 0.0569 0.6039

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = -9.16 Inhibition of human immunodeficiency virus type 1 (HIV-1) protease enzyme. ChEMBL. 11087569
IC50 (binding) = 9.155 Inhibitory activity against HIV-1 protease. ChEMBL. 10956210
Log IC50 (binding) = 9.15500000000002 Inhibitory activity against HIV-1 protease. ChEMBL. 10956210

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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