Detailed information for compound 171195

Basic information

Technical information
  • TDR Targets ID: 171195
  • Name: trimethyl-[2-(3-methylbutylsulfanylcarbonylox y)ethyl]azanium chloride
  • MW: 269.832 | Formula: C11H24ClNO2S
  • H donors: 0 H acceptors: 1 LogP: 3.6 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CCSC(=O)OCC[N+](C)(C)C)C.[Cl-]
  • InChi: 1S/C11H24NO2S.ClH/c1-10(2)6-9-15-11(13)14-8-7-12(3,4)5;/h10H,6-9H2,1-5H3;1H/q+1;/p-1
  • InChiKey: LBIXRLBLQPMXJP-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • 2-isopentylsulfanylcarbonyloxyethyl(trimethyl)ammonium chloride
  • 2-[(isopentylthio)-oxomethoxy]ethyl-trimethylammonium chloride
  • 2-(isoamylthio)carbonyloxyethyl-trimethyl-ammonium chloride
  • 2-isopentylsulfanylcarbonyloxyethyl-trimethyl-ammonium chloride

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Acetylcholinesterase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis BC026374 protein (S09 family) Acetylcholinesterase   613 aa 627 aa 33.8 %
Drosophila melanogaster CG10175 gene product from transcript CG10175-RE Acetylcholinesterase   613 aa 527 aa 32.3 %
Loa Loa (eye worm) hypothetical protein Acetylcholinesterase   613 aa 573 aa 26.5 %
Onchocerca volvulus Acetylcholinesterase   613 aa 552 aa 31.3 %
Loa Loa (eye worm) hypothetical protein Acetylcholinesterase   613 aa 561 aa 24.6 %
Echinococcus granulosus BC026374 protein S09 family Acetylcholinesterase   613 aa 627 aa 34.0 %
Brugia malayi Carboxylesterase family protein Acetylcholinesterase   613 aa 491 aa 26.7 %
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Acetylcholinesterase   613 aa 601 aa 23.6 %
Onchocerca volvulus Putative nuclear protein Acetylcholinesterase   613 aa 572 aa 41.6 %
Onchocerca volvulus Acetylcholinesterase   613 aa 613 aa 26.8 %
Onchocerca volvulus Molybdopterin synthase catalytic subunit homolog Acetylcholinesterase   613 aa 564 aa 30.3 %
Onchocerca volvulus Carnitine O-palmitoyltransferase 2, mitochondrial homolog Acetylcholinesterase   613 aa 511 aa 39.9 %
Echinococcus multilocularis neuroligin Acetylcholinesterase   613 aa 534 aa 23.2 %
Onchocerca volvulus Acetylcholinesterase   613 aa 565 aa 26.0 %
Brugia malayi Carboxylesterase family protein Acetylcholinesterase   613 aa 569 aa 31.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.004 0.004
Brugia malayi nuclear receptor NHR-67 0.0024 0.004 0.004
Echinococcus granulosus FTZ F1 alpha 0.005 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0107
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0112 0.0112
Brugia malayi jmjC domain containing protein 0.0016 0.002 0.002
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0021 0.0021
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0021 0.0021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0022 0.0063
Trypanosoma cruzi UDP-galactopyranose mutase 0.0105 0.0244 1
Brugia malayi MH2 domain containing protein 0.0008 0.0001 0.0001
Onchocerca volvulus Protein ultraspiracle homolog 0.005 0.0107 0.4378
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0024 0.0003
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0146 0.5969
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0023 0.0039 0.0039
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.002 0.002
Echinococcus granulosus dna polymerase kappa 0.0041 0.0084 0.0084
Brugia malayi glutathione reductase 0.0046 0.0096 0.0096
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.004 0.004
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0053 0.0053
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0039 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0022 0.1534
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0107 0.0107
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0027 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0059 0.0129 0.0129
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0021 0.0021
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.4001 1 1
Echinococcus multilocularis lamin dm0 0.0028 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0107
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.004 0.004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0092 0.0092
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0133 0.0356
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0021 0.0056
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.0107 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0022 0.1534
Trypanosoma brucei protein kinase, putative 0.0052 0.0112 0.7651
Echinococcus multilocularis acetylcholinesterase 0.035 0.0857 0.0857
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0107
Brugia malayi CXXC zinc finger family protein 0.0029 0.0053 0.0053
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0021 0.1427
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.005
Brugia malayi hypothetical protein 0.0242 0.0587 0.0587
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0039 0.0112
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0073 0.5028
Plasmodium falciparum glutathione reductase 0.0016 0.0021 0.0021
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.004
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.0107 0.0107
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0084 0.3419
Loa Loa (eye worm) hypothetical protein 0.0027 0.0048 0.0048
Echinococcus granulosus dnaJ subfamily B 0.0408 0.1003 0.1003
Onchocerca volvulus 0.0059 0.0129 0.5279
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0112 0.4567
Plasmodium vivax hypothetical protein, conserved 0.0105 0.0244 0.0244
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0019 0.0019
Brugia malayi Carboxylesterase family protein 0.0059 0.0129 0.0129
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0019 0.0793
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.004 0.004
Mycobacterium tuberculosis Carboxylesterase LipT 0.0059 0.0129 0.0373
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0107 0.0107
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0128 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0022 0.1534
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0107 0.0107
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0073 0.0073
Onchocerca volvulus 0.0059 0.0129 0.5279
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0043 0.0116
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.004
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0112 0.4567
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0084 0.5728
Echinococcus multilocularis dna polymerase eta 0.0014 0.0017 0.0017
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1388 0.3458 0.9996
Brugia malayi tailless protein 0.0024 0.004 0.004
Brugia malayi nuclear receptor RXR 0.0024 0.004 0.004
Echinococcus granulosus acetylcholinesterase 0.035 0.0857 0.0857
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0024 0.0024
Loa Loa (eye worm) carboxylesterase 0.0059 0.0129 0.0129
Mycobacterium tuberculosis Possible oxidoreductase 0.0105 0.0244 0.0706
Leishmania major cytochrome p450-like protein 0.0025 0.0043 0.1769
Echinococcus multilocularis BC026374 protein (S09 family) 0.0059 0.0129 0.0129
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.0711 0.0711
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.0107 0.0107
Echinococcus multilocularis protoporphyrinogen oxidase 0.0105 0.0244 0.0244
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0133 0.0356
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0039 0.0104
Mycobacterium ulcerans deoxycytidine triphosphate deaminase 0.1389 0.3459 0.9296
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0021 0.0021
Schistosoma mansoni lamin 0.0028 0.005 0.005
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.0107 0.0107
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0048 0.0048
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0024 0.007
Plasmodium falciparum thioredoxin reductase 0.0016 0.0021 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.0107 0.0107
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0021 0.0293
Loa Loa (eye worm) hypothetical protein 0.0027 0.0048 0.0048
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0092 0.0092
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0019 0.0019
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0135 0.0135
Brugia malayi MH1 domain containing protein 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0059 0.0059
Brugia malayi Carboxylesterase family protein 0.035 0.0857 0.0857
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.0711 0.0711
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0107 0.0107
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0084 0.0224
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0039 0.0104
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0107
Brugia malayi hypothetical protein 0.0024 0.004 0.004
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0146 0.0146
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0092 0.0092
Mycobacterium ulcerans deoxyuridine 5'-triphosphate nucleotidohydrolase 0.1389 0.3459 0.9296
Schistosoma mansoni thyroid hormone receptor 0.005 0.0107 0.0107
Leishmania major trypanothione reductase 0.0046 0.0096 0.3927
Schistosoma mansoni smad1 5 8 and 0.0008 0.0001 0.0001
Chlamydia trachomatis deoxyuridine 5'-triphosphate nucleotidohydrolase 0.4001 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.035 0.0857 0.0857
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0273 0.0788
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0107 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0073 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0084 0.5728
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.004 0.004
Schistosoma mansoni gliotactin 0.0059 0.0129 0.0129
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0001 0.0001
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0132 0.0132
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.002 0.002
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0096 0.0096
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0146 0.0146
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0017 0.0017
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0024 0.0024
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0073 0.0073
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0001 0.0001
Echinococcus multilocularis para nitrobenzyl esterase 0.0059 0.0129 0.0129
Echinococcus multilocularis FTZ F1 alpha 0.005 0.0107 0.0107
Brugia malayi polk-prov protein 0.0031 0.0059 0.0059
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0133 0.0133
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0018 0.0018
Schistosoma mansoni inositol monophosphatase 0.0037 0.0073 0.0073
Brugia malayi Inositol-1 0.0037 0.0073 0.0073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.0711 0.0711
Schistosoma mansoni amine oxidase 0.0105 0.0244 0.0244
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0146 0.0146
Trypanosoma cruzi UDP-galactopyranose mutase 0.0105 0.0244 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0073 0.0073
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0021 0.1427
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0076 0.0076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0021 0.0852
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1494 0.3721 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.0107 0.0107
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0135 0.0135
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0073 0.0073
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0096 0.0277
Schistosoma mansoni smad1 5 8 and 0.0008 0.0001 0.0001
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0059 0.0129 0.0373
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0039 0.0104
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.002 0.002
Echinococcus granulosus phd:f box containing protein 0.0016 0.002 0.002
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0112 0.4567
Echinococcus multilocularis neuroligin 0.0059 0.0129 0.0129
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0073 0.0073
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0273 0.0788
Echinococcus granulosus neuroligin 0.0059 0.0129 0.0129
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.002 0.002
Schistosoma mansoni thyroid hormone receptor 0.005 0.0107 0.0107
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0019 0.0019
Mycobacterium ulcerans carboxylesterase, LipT 0.0059 0.0129 0.0347
Echinococcus granulosus cpg binding protein 0.003 0.0057 0.0057
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0039 0.0104
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0021 0.0852
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.004 0.004
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.4001 1 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0019 0.1329
Loa Loa (eye worm) hypothetical protein 0.0059 0.0129 0.0129
Echinococcus multilocularis Smad4 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0105 0.0244 0.0244
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.004 0.004
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0021 0.1427
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0014 0.0014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0022 0.0063
Echinococcus multilocularis microtubule associated protein 2 0.2748 0.6861 0.6861
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0073 0.0073
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0073 0.3001
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0003 0.0003
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0084 0.0224
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0019 0.0019
Echinococcus granulosus acetylcholinesterase 0.035 0.0857 0.0857
Schistosoma mansoni nuclear receptor 0.0024 0.004 0.004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.0711 0.0711
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0084 0.5728
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.004
Brugia malayi nuclear hormone receptor 0.005 0.0107 0.0107
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1494 0.3721 1
Plasmodium vivax hypothetical protein, conserved 0.0105 0.0244 0.0244
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0133 0.0356
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.0107 0.0107
Schistosoma mansoni nuclear hormone receptor 0.0024 0.004 0.004
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0073 0.0073
Brugia malayi amine oxidase, flavin-containing family protein 0.0105 0.0244 0.0244
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0073 0.0073
Echinococcus granulosus carboxylesterase 5A 0.035 0.0857 0.0857
Mycobacterium leprae PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) 0.1389 0.3459 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0021 0.0021
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0001 0.0001
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0084 0.5728
Loa Loa (eye worm) DR-78 0.0024 0.004 0.004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0039 0.0112
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0019 0.0019
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0133 0.0383
Loa Loa (eye worm) hypothetical protein 0.0059 0.0129 0.0129
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0059 0.0129 0.0129
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0105 0.0244 0.0244
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0024 0.0024
Brugia malayi jmjC domain containing protein 0.0059 0.0128 0.0128
Brugia malayi Carboxylesterase family protein 0.0059 0.0129 0.0129
Brugia malayi steroid hormone receptor 0.005 0.0107 0.0107
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0048 0.0048
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.4001 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0022 0.0063
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0019 0.1329
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0021 0.0021
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0128 0.0128
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0243 0.0703
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0146 0.0146
Schistosoma mansoni cpg binding protein 0.0029 0.0053 0.0053
Treponema pallidum deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) 0.4001 1 1
Echinococcus granulosus para nitrobenzyl esterase 0.0059 0.0129 0.0129
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0021 0.0852
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.004
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0027 0.0048 0.0048
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0135 0.0135
Leishmania major DNA polymerase kappa, putative 0.0021 0.0034 0.1375
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0073 0.2997
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0039 0.0112
Echinococcus multilocularis smad 0.0008 0.0001 0.0001
Wolbachia endosymbiont of Brugia malayi dUTPase 0.4001 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0107 0.0107
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0048 0.0048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.004 0.004
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0023 0.0039 0.0039
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0021 0.0021
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0273 0.0788
Brugia malayi jmjC domain containing protein 0.0016 0.002 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0084 0.5728
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0073 0.0073
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0084 0.3419
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.001 0.001
Schistosoma mansoni phd/f-box containing protein 0.0016 0.002 0.002
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0059 0.0129 0.0129
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0024 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.0107 0.0107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0021 0.0852
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0003 0.0003
Toxoplasma gondii thioredoxin reductase 0.0046 0.0096 0.0096
Brugia malayi Nuclear hormone receptor E75 0.0024 0.004 0.004
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0133 0.0133
Mycobacterium tuberculosis Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) 0.1389 0.3459 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0084 0.5728
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.004 0.004
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.4001 1 1
Brugia malayi Smad1 0.0008 0.0001 0.0001
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.0107 0.0107
Schistosoma mansoni protein phosphatase 2C 0.0016 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0024
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.002 0.002
Echinococcus granulosus microtubule associated protein 2 0.2748 0.6861 0.6861
Echinococcus granulosus dUTP pyrophosphatase 0.4001 1 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0105 0.0244 0.0244
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.004 0.004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0092 0.0092
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.004
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.004 0.1653
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.004
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.1003 0.1003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0092 0.0092
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.004 0.004
Echinococcus granulosus Smad4 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0105 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.004
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0039 0.0039
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.004 0.004
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0096 0.3927
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0105 0.0244 0.0244
Leishmania major hypothetical protein, conserved 0.0016 0.002 0.0824
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0021 0.1427
Echinococcus granulosus lamin 0.0028 0.005 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0092 0.0092
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0073 0.0073
Trypanosoma brucei unspecified product 0.001 0.0006 0.0404
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.002 0.002
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0112 0.4567
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0073 0.1031
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0073
Plasmodium vivax deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.4001 1 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0128 0.0128
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0034 0.0097
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0021 0.0852
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0105 0.0244 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.004
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0128 0.0128
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.4001 1 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0017 0.0017
Onchocerca volvulus 0.0028 0.005 0.205
Loa Loa (eye worm) hypothetical protein 0.0059 0.0129 0.0129
Onchocerca volvulus 0.0024 0.004 0.1653
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.004 0.004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.004 0.004
Onchocerca volvulus 0.0014 0.0017 0.0693
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.0338 0.0907
Entamoeba histolytica hypothetical protein 0.2612 0.6522 0.6522
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0107 0.0107
Entamoeba histolytica hypothetical protein 0.1389 0.3459 0.3459
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0092 0.0092
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0107 0.0107
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0019 0.0019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0092 0.0092
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0135 0.0135
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0107 0.0107
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.0711 0.0711
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0018 0.0018
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0117 0.0117
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.004 0.004
Brugia malayi ecdysteroid receptor 0.005 0.0107 0.0107
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0073 0.0073
Brugia malayi Thioredoxin reductase 0.0046 0.0096 0.0096
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.004 0.004
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0112 0.0112
Trypanosoma brucei DNA polymerase eta, putative 0.0014 0.0017 0.1173
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0107
Mycobacterium tuberculosis Conserved hypothetical protein 0.0014 0.0017 0.0049
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0105 0.0244 0.0244
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0017 0.0017
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0059 0.0129 0.0129
Brugia malayi Nuclear hormone receptor E75 0.0024 0.004 0.004
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.002 0.002
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.004 0.004
Plasmodium falciparum glutathione reductase 0.0046 0.0096 0.0096
Onchocerca volvulus 0.0024 0.004 0.1653
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0112 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0084 0.5728
Loa Loa (eye worm) carboxylesterase 0.0059 0.0129 0.0129
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.0711 0.0711
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.0711 0.0711
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0022 0.0063
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0003 0.0003
Echinococcus granulosus dna polymerase eta 0.0014 0.0017 0.0017
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0271 0.0271
Trichomonas vaginalis deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.4001 1 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0021 0.0021
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0073 0.2997
Loa Loa (eye worm) carboxylesterase 0.035 0.0857 0.0857
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.0587 0.0587
Brugia malayi jmjC domain containing protein 0.0016 0.002 0.002
Schistosoma mansoni microtubule-associated protein tau 0.2748 0.6861 0.6861
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0019 0.0793
Brugia malayi nuclear receptor NHR-88 0.005 0.0107 0.0107
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0021 0.0056
Onchocerca volvulus 0.0059 0.0129 0.5279
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.002
Schistosoma mansoni smad1 5 8 and 0.0008 0.0001 0.0001
Schistosoma mansoni amine oxidase 0.0105 0.0244 0.0244
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0021 0.006
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0021 0.0852
Brugia malayi jmjC domain containing protein 0.006 0.0132 0.0132
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0064 0.0184
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.005 0.005
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.005 0.0107 0.4378
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0105 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.0107 0.0107
Echinococcus multilocularis dUTP pyrophosphatase 0.4001 1 1
Onchocerca volvulus 0.0059 0.0129 0.5279
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0039 0.0104
Echinococcus granulosus lysine specific histone demethylase 1A 0.0105 0.0244 0.0244
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0105 0.0244 0.0244
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0133 0.0133
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0073 0.0073
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0107 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0027 0.0048 0.0048
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0039 0.1581
Trypanosoma brucei unspecified product 0.001 0.0006 0.0404
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0049 0.0105 0.0105
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0034 0.1375
Brugia malayi Cytochrome P450 family protein 0.0025 0.0043 0.0043
Brugia malayi Cytochrome P450 family protein 0.0025 0.0043 0.0043
Echinococcus multilocularis thyroid hormone receptor alpha 0.005 0.0107 0.0107
Wolbachia endosymbiont of Brugia malayi deoxycytidine triphosphate deaminase 0.1389 0.3459 0.3459
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0019 0.0019
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.0107 0.0107
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0017 0.0017
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.0338 0.0976
Loa Loa (eye worm) glutathione reductase 0.0046 0.0096 0.0096
Brugia malayi hypothetical protein 0.0105 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0105 0.0244 0.0244
Echinococcus granulosus smad 0.0008 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.004
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0112 0.7651
Schistosoma mansoni Smad4 0.0008 0.0001 0.0001
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0135 0.0135
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0243 0.0703
Giardia lamblia Fructose-bisphosphate aldolase 0.0292 0.0711 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0112 0.0112
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0132 0.0132
Toxoplasma gondii deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.4001 1 1
Loa Loa (eye worm) dUTP diphosphatase 0.4001 1 1
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0073 0.0073
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0011 0.0009 0.0009
Echinococcus multilocularis carboxylesterase 5A 0.035 0.0857 0.0857
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0021 0.0852
Brugia malayi RNA binding protein 0.0062 0.0135 0.0135
Brugia malayi hypothetical protein 0.0024 0.004 0.004
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.002 0.002
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.002
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.0338 0.0976
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.002 0.002
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0073 0.3001
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0073 0.3001
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.002 0.0824
Loa Loa (eye worm) inositol-1 0.0037 0.0073 0.0073
Schistosoma mansoni cpg binding protein 0.003 0.0057 0.0057
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0059 0.0129 0.0129
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0135 0.0135
Onchocerca volvulus 0.0049 0.0105 0.4281
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0021 0.0021
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0059 0.0129 0.0373
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0021 0.0021
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0021 0.0852
Brugia malayi nuclear receptor RXR 0.0027 0.0048 0.0048
Trichomonas vaginalis spcc417.12 protein, putative 0.0059 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0014
Schistosoma mansoni zinc finger protein 0.0024 0.004 0.004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.004
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.0107 0.0107
Mycobacterium tuberculosis Probable reductase 0.0105 0.0243 0.0703
Echinococcus multilocularis acetylcholinesterase 0.035 0.0857 0.0857
Onchocerca volvulus 0.005 0.0107 0.4378
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.005 0.005
Leishmania major UDP-galactopyranose mutase 0.0105 0.0244 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0135 0.0135
Brugia malayi MH1 domain containing protein 0.0008 0.0001 0.0001
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.0107 0.0107
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.002 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0092 0.0092
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0048 0.0048
Brugia malayi TAR-binding protein 0.0062 0.0135 0.0135
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.004 0.004
Loa Loa (eye worm) RNA binding protein 0.0062 0.0135 0.0135
Trypanosoma brucei unspecified product 0.0034 0.0067 0.4598
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0019 0.0019
Mycobacterium tuberculosis Conserved hypothetical protein 0.0105 0.0244 0.0706
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.0107 0.0107
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.0107 0.0107
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0107 0.0107
Plasmodium vivax JmjC domain containing protein 0.0016 0.002 0.002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.0107 0.0107
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.0107 0.0107
Brugia malayi isocitrate dehydrogenase 0.0015 0.0019 0.0019
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0039 0.0104
Schistosoma mansoni acetylcholinesterase 0.0059 0.0129 0.0129
Brugia malayi Carboxylesterase family protein 0.0059 0.0129 0.0129
Schistosoma mansoni smad 0.0008 0.0001 0.0001
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0105 0.0244 0.0706
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.002 0.0824
Mycobacterium ulcerans monoamine oxidase 0.0105 0.0244 0.0657
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0146 0.0146
Mycobacterium ulcerans oxidoreductase 0.0105 0.0244 0.0657
Schistosoma mansoni cpg binding protein 0.003 0.0057 0.0057
Onchocerca volvulus 0.0105 0.0244 1
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0096 0.0096
Echinococcus multilocularis phd:f box containing protein 0.0016 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.004
Brugia malayi conserved hypotetical protein 0.0024 0.004 0.004
Onchocerca volvulus Bile acid receptor homolog 0.005 0.0107 0.4378
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.0107 0.0107
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0001 0.0001
Onchocerca volvulus 0.0028 0.005 0.205
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0112 0.0112
Mycobacterium ulcerans hypothetical protein 0.0023 0.0039 0.0104
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0146 0.5969
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0021 0.0852
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.0107 0.0107
Schistosoma mansoni intermediate filament proteins 0.0028 0.005 0.005
Loa Loa (eye worm) acetylcholinesterase 1 0.035 0.0857 0.0857
Onchocerca volvulus 0.0023 0.0039 0.1581
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0039 0.0039
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0021 0.0021
Brugia malayi jmjC domain containing protein 0.0016 0.002 0.002
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0039 0.0104
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0073 0.502
Echinococcus multilocularis lamin 0.0028 0.005 0.005
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0112 0.0112
Treponema pallidum fructose-bisphosphate aldolase 0.0292 0.0711 0.0692
Brugia malayi intermediate filament protein 0.0028 0.005 0.005
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0019 0.0019
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.004 0.004
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.4001 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.0711 0.0711
Echinococcus multilocularis musashi 0.0028 0.005 0.005
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0059 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0017
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0146 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.002
Schistosoma mansoni DNA polymerase eta 0.0014 0.0017 0.0017
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.0107 0.0107
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.0107 0.0107
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0243 0.0703
Trypanosoma cruzi DNA polymerase eta, putative 0.0014 0.0017 0.07
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0017 0.0017
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0043 0.0043
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0043 0.1769
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.0107 0.0107
Brugia malayi Carboxylesterase family protein 0.035 0.0857 0.0857
Brugia malayi Steroid receptor seven-up type 2 0.005 0.0107 0.0107
Schistosoma mansoni nuclear hormone receptor 0.0024 0.004 0.004
Giardia lamblia DINP protein human, muc B family 0.0021 0.0034 0.0472
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0133 0.0133
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0003 0.0003
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0043 0.2963
Entamoeba histolytica deoxycytidine triphosphate deaminase, putative 0.1389 0.3459 0.3459
Plasmodium vivax glutathione reductase, putative 0.0046 0.0096 0.0096
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.0107 0.0107
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0043 0.1769
Brugia malayi hypothetical protein 0.0059 0.0129 0.0129
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0001 0.0001
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0064 0.0184
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0024
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0021 0.0852
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0001 0.0001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0039 0.0039
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0105 0.0244 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.0107 0.0107
Schistosoma mansoni neuroligin 3 (S09 family) 0.0059 0.0129 0.0129
Brugia malayi MAP kinase sur-1 0.0052 0.0112 0.0112
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0019 0.0793
Brugia malayi nuclear receptor NHR-88 0.0024 0.004 0.004
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0059 0.0129 0.0129
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0039 0.0039
Echinococcus granulosus lysine specific histone demethylase 1A 0.0105 0.0244 0.0244
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.004 0.004
Echinococcus granulosus intermediate filament protein 0.0028 0.005 0.005
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, putative 0.1389 0.3459 0.3459
Brugia malayi hypothetical protein 0.0027 0.0048 0.0048
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0014 0.0014
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0107
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.001 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0084 0.5728
Loa Loa (eye worm) hypothetical protein 0.035 0.0857 0.0857
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0084 0.0084
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.0711 0.0711
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0073 0.0073
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.035 0.0857 0.0857
Echinococcus granulosus tar DNA binding protein 0.0062 0.0135 0.0135
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.004 0.004
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.0107 0.0107
Schistosoma mansoni coup transcription factor 0.005 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0024
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0105 0.0244 0.0244
Echinococcus multilocularis 0.0105 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0024
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0017 0.0017
Echinococcus granulosus lamin dm0 0.0028 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0242 0.0587 0.0587
Brugia malayi MH2 domain containing protein 0.0116 0.0271 0.0271
Mycobacterium ulcerans dehydrogenase 0.0105 0.0244 0.0657
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.002 0.1381
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0243 0.0703
Entamoeba histolytica hypothetical protein 0.4001 1 1
Brugia malayi hypothetical protein 0.0027 0.0048 0.0048
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0133 0.5428
Plasmodium falciparum protoporphyrinogen oxidase 0.0105 0.0244 0.0244
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.0107 0.0107
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0073 0.0073
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0059 0.0129 0.0129
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0039 0.1581
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0107
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0112 0.0112
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.004 0.1653
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.0107 0.0107
Plasmodium falciparum thioredoxin reductase 0.0046 0.0096 0.0096
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.0711 0.0711
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0273 0.0788
Chlamydia trachomatis deoxycytidine triphosphate deaminase 0.1389 0.3459 0.3446
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0048 0.0048
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0132 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0107 0.0107
Brugia malayi ecdysone receptor 0.0024 0.004 0.004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0084 0.3419
Schistosoma mansoni lamin 0.0028 0.005 0.005
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0039 0.1581
Schistosoma mansoni survival motor neuron protein 0.0049 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0027 0.0049 0.0049
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.0107 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0084 0.5728
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0021 0.0852
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0019 0.0019
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0021 0.0021
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0112 0.0112
Entamoeba histolytica deoxycytidyl transferase, putative 0.0014 0.0017 0.0017
Schistosoma mansoni nuclear hormone receptor 0.005 0.0107 0.0107
Schistosoma mansoni BC026374 protein (S09 family) 0.0059 0.0129 0.0129
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0073 0.0073
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0112 0.0112
Loa Loa (eye worm) Smad1 0.0008 0.0001 0.0001
Brugia malayi Carboxylesterase family protein 0.0059 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0059 0.0129 0.0129
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.002 0.002
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0067 0.4598
Schistosoma mansoni jumonji domain containing protein 0.0016 0.002 0.002
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0105 0.0244 0.0244
Brugia malayi nuclear hormone receptor 0.0024 0.004 0.004
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0105 0.0244 0.0244
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0043 0.0043
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0243 0.0703
Onchocerca volvulus 0.0029 0.0053 0.2157
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0135 0.0135
Brugia malayi SWIRM domain containing protein 0.0105 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0107 0.0107
Chlamydia trachomatis protoporphyrinogen oxidase 0.0105 0.0244 0.0224
Echinococcus multilocularis cpg binding protein 0.003 0.0057 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0059 0.4018
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0243 0.0703
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.0107 0.0107
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.002 0.002
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0146 0.5969
Entamoeba histolytica hypothetical protein 0.4001 1 1
Trypanosoma brucei trypanothione reductase 0.0046 0.0096 0.658
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0112 0.4567
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.002 0.002
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0039 0.0112
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0048 0.0048
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0048 0.0048
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0073 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0084 0.5728
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0021 0.0056
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0073 0.2997
Loa Loa (eye worm) intermediate filament protein 0.0028 0.005 0.005
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0112 0.4567
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0084 0.0084
Entamoeba histolytica hypothetical protein 0.2612 0.6522 0.6522
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0034 0.2303
Leishmania major DNA polymerase eta, putative 0.0014 0.0017 0.07
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0076 0.0076
Onchocerca volvulus 0.0059 0.0129 0.5279
Brugia malayi MH2 domain containing protein 0.0008 0.0001 0.0001
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0059 0.0129 0.0129
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0084 0.3419
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0112 0.1569
Schistosoma mansoni inositol monophosphatase 0.0037 0.0073 0.0073
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0112 0.0112
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.0587 0.0587
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0408 0.1003 0.1003
Echinococcus granulosus BC026374 protein S09 family 0.0059 0.0129 0.0129
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0021 0.0852
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0132 0.0132
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.004 0.004
Schistosoma mansoni nuclear receptor 0.0024 0.004 0.004
Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase 0.4001 1 1
Loa Loa (eye worm) steroid hormone receptor 0.005 0.0107 0.0107
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0073 0.0197
Schistosoma mansoni deoxyuridine 5'-triphosphate nucleotidohydrolase 0.4001 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0112 0.0112
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.0107 0.0107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0021 0.0852
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0107
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0135 0.0135
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0105 0.0244 0.0657
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0025
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0019 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0059 0.4018
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0146 0.0146
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0084 0.5728
Toxoplasma gondii histone lysine-specific demethylase 0.0105 0.0244 0.0244

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.00001 M Inhibition of Acetylcholinesterase activity of calf forebrain ChEMBL. 9301662
IC50 (binding) = 0.00001 M Inhibition of Acetylcholinesterase activity of calf forebrain ChEMBL. 9301662
IC50 (binding) = 0.00005 M Inhibition of Acetylcholinesterase from human red blood cells ChEMBL. 9301662
IC50 (binding) = 0.00005 M Inhibition of Acetylcholinesterase activity from octopus brain ChEMBL. 9301662
IC50 (binding) = 0.00005 M Inhibition of Acetylcholinesterase from human red blood cells ChEMBL. 9301662
IC50 (binding) = 0.00005 M Inhibition of Acetylcholinesterase activity from octopus brain ChEMBL. 9301662

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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