TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 612.676 | Formula: C33H36N6O6
H donors: 6 H acceptors: 5 LogP: 1.43 Rotable bonds: 15
Rule of 5 violations (Lipinski): 3
SMILES: Oc1ccc(cc1)C[C@@H](C(=O)N1CC[C@H](C1)C(=O)N[C@H](C(=O)N[C@H](C(=C)C(=O)N)c1ccco1)Cc1c[nH]c2c1cccc2)N
InChi: 1S/C33H36N6O6/c1-19(30(35)41)29(28-7-4-14-45-28)38-32(43)27(16-22-17-36-26-6-3-2-5-24(22)26)37-31(42)21-12-13-39(18-21)33(44)25(34)15-20-8-10-23(40)11-9-20/h2-11,14,17,21,25,27,29,36,40H,1,12-13,15-16,18,34H2,(H2,35,41)(H,37,42)(H,38,43)/t21-,25+,27+,29-/m1/s1
InChiKey: QYOGKEMLQNWNLK-JNAYRKKUSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	opioid receptor, mu 1	Starlite/ChEMBL	References
Cavia porcellus	Mu opioid receptor	Starlite/ChEMBL	References
Homo sapiens	opioid receptor, mu 1	Starlite/ChEMBL	References
Homo sapiens	opioid receptor, delta 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	tm gpcr rhodopsin	Get druggable targets OG5_139759	All targets in OG5_139759
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Get druggable targets OG5_139759	All targets in OG5_139759

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Mu opioid receptor	98 aa	79 aa	27.8 %
Schistosoma mansoni	rhodopsin-like orphan GPCR	Mu opioid receptor	98 aa	85 aa	25.9 %
Onchocerca volvulus		Mu opioid receptor	98 aa	80 aa	22.5 %
Echinococcus multilocularis	rhodopsin orphan GPCR	Mu opioid receptor	98 aa	80 aa	23.8 %
Echinococcus multilocularis	tachykinin peptides receptor 99D	Mu opioid receptor	98 aa	93 aa	25.8 %
Echinococcus multilocularis	serotonin receptor	Mu opioid receptor	98 aa	97 aa	35.1 %
Schistosoma japonicum	5-hydroxytryptamine receptor 4, putative	Mu opioid receptor	98 aa	79 aa	36.7 %
Schistosoma mansoni	biogenic amine (dopamine) receptor	Mu opioid receptor	98 aa	88 aa	39.8 %
Onchocerca volvulus	26S proteasome non-ATPase regulatory subunit 1 homolog	Mu opioid receptor	98 aa	80 aa	28.8 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	79 aa	29.1 %
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	Mu opioid receptor	98 aa	96 aa	29.2 %
Schistosoma japonicum	Neuropeptide Y receptor type 2, putative	Mu opioid receptor	98 aa	79 aa	31.6 %
Schistosoma japonicum	ko:K04282 thyrotropin-releasing hormone receptor, putative	Mu opioid receptor	98 aa	100 aa	28.0 %
Echinococcus granulosus	neuropeptide receptor	Mu opioid receptor	98 aa	88 aa	22.7 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Mu opioid receptor	98 aa	90 aa	28.9 %
Onchocerca volvulus		Mu opioid receptor	98 aa	79 aa	27.8 %
Schistosoma mansoni	neuropeptide receptor	Mu opioid receptor	98 aa	81 aa	34.6 %
Echinococcus granulosus	neuropeptide Y receptor	Mu opioid receptor	98 aa	95 aa	32.6 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Mu opioid receptor	98 aa	97 aa	36.1 %
Onchocerca volvulus		Mu opioid receptor	98 aa	85 aa	32.9 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Mu opioid receptor	98 aa	93 aa	25.8 %
Onchocerca volvulus		Mu opioid receptor	98 aa	96 aa	24.0 %
Brugia malayi	ORL1-like opioid receptor	Mu opioid receptor	98 aa	85 aa	32.9 %
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	Mu opioid receptor	98 aa	100 aa	29.0 %
Schistosoma mansoni	biogenic amine (dopamine) receptor	Mu opioid receptor	98 aa	97 aa	35.1 %
Schistosoma mansoni	neuropeptide receptor	Mu opioid receptor	98 aa	95 aa	32.6 %
Schistosoma japonicum	Neuropeptide Y receptor, putative	Mu opioid receptor	98 aa	88 aa	23.9 %
Onchocerca volvulus	Phospholipase d-related homolog	Mu opioid receptor	98 aa	82 aa	25.6 %
Loa Loa (eye worm)	TYRA-2 protein	Mu opioid receptor	98 aa	87 aa	31.0 %
Schistosoma japonicum	Muscarinic acetylcholine receptor M1, putative	Mu opioid receptor	98 aa	95 aa	30.5 %
Onchocerca volvulus		Mu opioid receptor	98 aa	100 aa	25.0 %
Onchocerca volvulus		Mu opioid receptor	98 aa	87 aa	32.2 %
Schistosoma japonicum	Probable G-protein coupled receptor No9, putative	Mu opioid receptor	98 aa	95 aa	28.4 %
Loa Loa (eye worm)	neuropeptide F receptor	Mu opioid receptor	98 aa	80 aa	33.8 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	92 aa	31.5 %
Brugia malayi	larval opioid receptor	Mu opioid receptor	98 aa	100 aa	24.0 %
Echinococcus multilocularis	biogenic amine (5HT) receptor	Mu opioid receptor	98 aa	96 aa	30.2 %
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	Mu opioid receptor	98 aa	80 aa	37.5 %
Onchocerca volvulus		Mu opioid receptor	98 aa	80 aa	35.0 %
Loa Loa (eye worm)	melatonin receptor type 1A	Mu opioid receptor	98 aa	80 aa	22.5 %
Schistosoma mansoni	biogenic amine receptor	Mu opioid receptor	98 aa	97 aa	38.1 %
Echinococcus granulosus	g protein coupled receptor	Mu opioid receptor	98 aa	92 aa	26.1 %
Echinococcus multilocularis	neuropeptide receptor	Mu opioid receptor	98 aa	88 aa	22.7 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	92 aa	23.9 %
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	Mu opioid receptor	98 aa	99 aa	36.4 %
Onchocerca volvulus		Mu opioid receptor	98 aa	79 aa	31.6 %
Echinococcus granulosus	alpha 1A adrenergic receptor	Mu opioid receptor	98 aa	92 aa	21.7 %
Schistosoma mansoni	opsin-like receptor	Mu opioid receptor	98 aa	80 aa	25.0 %
Onchocerca volvulus		Mu opioid receptor	98 aa	81 aa	25.9 %
Echinococcus granulosus	biogenic amine 5HT receptor	Mu opioid receptor	98 aa	96 aa	30.2 %
Onchocerca volvulus		Mu opioid receptor	98 aa	101 aa	20.8 %
Schistosoma japonicum	ko:K04165 Oamb gene product from transcript, putative	Mu opioid receptor	98 aa	79 aa	34.2 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Mu opioid receptor	98 aa	89 aa	30.3 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Mu opioid receptor	98 aa	96 aa	36.5 %
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	Mu opioid receptor	98 aa	97 aa	36.1 %
Echinococcus granulosus	tachykinin peptides receptor 99D	Mu opioid receptor	98 aa	93 aa	25.8 %
Schistosoma japonicum	Octopamine receptor, putative	Mu opioid receptor	98 aa	88 aa	37.5 %
Onchocerca volvulus		Mu opioid receptor	98 aa	93 aa	36.6 %
Onchocerca volvulus		Mu opioid receptor	98 aa	96 aa	28.1 %
Echinococcus granulosus	neuropeptide FF receptor 2	Mu opioid receptor	98 aa	84 aa	31.0 %
Echinococcus multilocularis	neuropeptide Y receptor	Mu opioid receptor	98 aa	95 aa	32.6 %
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	Mu opioid receptor	98 aa	93 aa	33.3 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	98 aa	31.6 %
Schistosoma japonicum	Alpha-1A adrenergic receptor, putative	Mu opioid receptor	98 aa	98 aa	34.7 %
Onchocerca volvulus		Mu opioid receptor	98 aa	79 aa	21.5 %
Brugia malayi	Serotonin/octopamine receptor family protein 7	Mu opioid receptor	98 aa	85 aa	32.9 %
Schistosoma japonicum	FMRFamide receptor, putative	Mu opioid receptor	98 aa	109 aa	28.4 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	93 aa	30.1 %
Echinococcus granulosus	biogenic amine 5HT receptor	Mu opioid receptor	98 aa	97 aa	35.1 %
Schistosoma japonicum	Neuropeptide Y receptor, putative	Mu opioid receptor	98 aa	100 aa	29.0 %
Onchocerca volvulus		Mu opioid receptor	98 aa	89 aa	31.5 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Mu opioid receptor	98 aa	100 aa	33.0 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Mu opioid receptor	98 aa	89 aa	40.4 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	85 aa	37.6 %
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	Mu opioid receptor	98 aa	96 aa	29.2 %
Echinococcus multilocularis	allatostatin A receptor	Mu opioid receptor	98 aa	99 aa	33.3 %
Schistosoma mansoni	biogenic amine receptor	Mu opioid receptor	98 aa	98 aa	35.7 %
Schistosoma mansoni	adenoreceptor	Mu opioid receptor	98 aa	88 aa	38.6 %
Schistosoma mansoni	growth hormone secretagogue receptor	Mu opioid receptor	98 aa	93 aa	24.7 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	96 aa	31.2 %
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	Mu opioid receptor	98 aa	96 aa	32.3 %
Schistosoma japonicum	ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative	Mu opioid receptor	98 aa	97 aa	37.1 %
Schistosoma mansoni	hypothetical protein	Mu opioid receptor	98 aa	100 aa	23.0 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Mu opioid receptor	98 aa	100 aa	34.0 %
Onchocerca volvulus		Mu opioid receptor	98 aa	86 aa	33.7 %
Schistosoma mansoni	biogenic amine receptor	Mu opioid receptor	98 aa	91 aa	38.5 %
Schistosoma mansoni	neuropeptide receptor	Mu opioid receptor	98 aa	93 aa	24.7 %
Schistosoma mansoni	neuropeptide F-like receptor	Mu opioid receptor	98 aa	85 aa	32.9 %
Schistosoma japonicum	Octopamine receptor, putative	Mu opioid receptor	98 aa	98 aa	37.8 %
Echinococcus multilocularis	g protein coupled receptor	Mu opioid receptor	98 aa	81 aa	24.7 %
Onchocerca volvulus		Mu opioid receptor	98 aa	81 aa	33.3 %
Schistosoma mansoni	amine GPCR	Mu opioid receptor	98 aa	86 aa	32.6 %
Echinococcus granulosus	allatostatin A receptor	Mu opioid receptor	98 aa	99 aa	33.3 %
Schistosoma japonicum	ko:K04207 neuropeptide Y receptor Y5, putative	Mu opioid receptor	98 aa	80 aa	31.2 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Mu opioid receptor	98 aa	97 aa	34.0 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Mu opioid receptor	98 aa	85 aa	34.1 %
Onchocerca volvulus	RB1-inducible coiled-coil protein 1 homolog	Mu opioid receptor	98 aa	96 aa	31.2 %
Brugia malayi	Melatonin receptor type 1A	Mu opioid receptor	98 aa	80 aa	22.5 %
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	Mu opioid receptor	98 aa	100 aa	29.0 %
Echinococcus multilocularis	neuropeptide FF receptor 2	Mu opioid receptor	98 aa	84 aa	31.0 %
Schistosoma japonicum	Rhodopsin, putative	Mu opioid receptor	98 aa	122 aa	22.1 %
Schistosoma mansoni	thyrotropin-releasing hormone receptor	Mu opioid receptor	98 aa	100 aa	27.0 %
Echinococcus multilocularis	g protein coupled receptor	Mu opioid receptor	98 aa	92 aa	26.1 %
Onchocerca volvulus	Glycoprotein hormone beta 5 homolog	Mu opioid receptor	98 aa	92 aa	32.6 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	81 aa	35.8 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Mu opioid receptor	98 aa	89 aa	38.2 %
Brugia malayi	G protein-coupled receptor	Mu opioid receptor	98 aa	90 aa	31.1 %
Echinococcus granulosus	g protein coupled receptor	Mu opioid receptor	98 aa	81 aa	24.7 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Mu opioid receptor	98 aa	96 aa	32.3 %
Onchocerca volvulus		Mu opioid receptor	98 aa	85 aa	24.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	g protein coupled receptor	0.0031	0.0071	0.0047
Toxoplasma gondii	subtilisin SUB6	0.0061	0.0243	0.6624
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0029	0.0062	0.021
Schistosoma mansoni	hypothetical protein	0.0031	0.0071	0.0047
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0071
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0061	0.0243	0.0243
Schistosoma mansoni	hypothetical protein	0.0031	0.0071	0.0047
Entamoeba histolytica	heat shock protein 90, putative	0.0037	0.0104	1
Trichomonas vaginalis	conserved hypothetical protein	0.0277	0.147	0.3885
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Trichomonas vaginalis	conserved hypothetical protein	0.0277	0.147	0.3885
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0057	0.1528
Echinococcus granulosus	heat shock protein 90	0.0037	0.0104	0.0081
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0057	0.1012
Toxoplasma gondii	subtilisin SUB9	0.0061	0.0243	0.6624
Trichomonas vaginalis	heat shock protein, putative	0.0037	0.0104	0.0217
Trichomonas vaginalis	conserved hypothetical protein	0.0277	0.147	0.3885
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0031	0.0071	0.0047
Echinococcus granulosus	7tm_1 domain containing protein	0.0031	0.0071	0.0047
Echinococcus multilocularis	serotonin receptor	0.0031	0.0071	0.0047
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.019	0.019
Schistosoma mansoni	inhibitor of apoptosis protein	0.1778	1	1
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.1778	1	1
Giardia lamblia	High cysteine membrane protein Group 2	0.0339	0.1824	1
Schistosoma mansoni	hypothetical protein	0.0278	0.1473	0.1453
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0031	0.0071	0.0047
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0386	0.2088	0.5545
Trypanosoma brucei	heat shock protein, putative	0.0037	0.0104	0.367
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0386	0.2088	0.5545
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0243	0.059
Leishmania major	heat shock protein 83-1	0.0037	0.0104	0.367
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0031	0.0071	0.0047
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0031	0.0071	0.0047
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0061	0.0243	1
Echinococcus granulosus	caspase 2	0.0278	0.1473	0.1453
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0031	0.0071	0.0071
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0109	0.0513	0.1316
Trichomonas vaginalis	conserved hypothetical protein	0.0277	0.147	0.3885
Echinococcus multilocularis	neuropeptide s receptor	0.0031	0.0071	0.0047
Echinococcus granulosus	neuroendocrine convertase 2	0.0947	0.528	0.5269
Echinococcus multilocularis	epidermal growth factor receptor	0.0181	0.0924	0.0902
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0071	0.0047
Echinococcus granulosus	tm gpcr rhodopsin	0.0656	0.3623	0.3607
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Echinococcus granulosus	fmrfamide receptor	0.0031	0.0071	0.0047
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0061	0.0243	1
Echinococcus granulosus	heat shock protein	0.0037	0.0104	0.0081
Brugia malayi	Dopamine receptor protein 1	0.0031	0.0071	0.0071
Schistosoma mansoni	trithorax protein ash2	0.0088	0.0395	0.0371
Onchocerca volvulus		0.0278	0.1473	0.1413
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0656	0.3623	0.3607
Schistosoma mansoni	hypothetical protein	0.0031	0.0071	0.0047
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0031	0.0071	0.0071
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0071	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0757	0.0735
Echinococcus multilocularis	rho associated protein kinase	0.0145	0.0718	0.0695
Loa Loa (eye worm)	hypothetical protein	0.1778	1	1
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0386	0.2088	0.2069
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0071	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0057	0.1726
Leishmania major	heat shock protein 83-1	0.0037	0.0104	0.367
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Plasmodium vivax	endoplasmin, putative	0.0037	0.0104	0.2171
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0031	0.0071	0.0047
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0031	0.0071	0.0047
Brugia malayi	neuropeptide F receptor	0.0031	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Toxoplasma gondii	subtilisin SUB11	0.0061	0.0243	0.6624
Giardia lamblia	Furin precursor putative serine protease	0.0325	0.174	0.9534
Echinococcus multilocularis	set1:ash2 histone methyltransferase complex	0.0088	0.0395	0.0371
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0071	0.0047
Echinococcus granulosus	microtubule associated protein 2	0.0781	0.4335	0.4321
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0301	0.1605	0.1585
Brugia malayi	Serotonin receptor	0.0031	0.0071	0.0071
Toxoplasma gondii	subtilisin SUB1	0.0061	0.0243	0.6624
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0071	0.0047
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Trypanosoma brucei	heat shock protein, putative	0.0037	0.0104	0.367
Trypanosoma cruzi	heat shock protein 85, putative	0.0037	0.0104	0.3818
Brugia malayi	Will die slowly protein	0.022	0.1147	0.1147
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0029	0.0062	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0031	0.0071	0.0071
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Loa Loa (eye worm)	TYRA-2 protein	0.0031	0.0071	0.0047
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0301	0.1605	0.1585
Leishmania major	heat shock protein 83-1	0.0037	0.0104	0.367
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Trypanosoma cruzi	heat shock protein 85, putative	0.0037	0.0104	0.3818
Plasmodium vivax	subtilisin-like protease 2, putative	0.0061	0.0243	0.5914
Echinococcus multilocularis	caspase 2	0.0278	0.1473	0.1453
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Schistosoma mansoni	myosin xvIII	0.0031	0.0071	0.0047
Loa Loa (eye worm)	AGC/DMPK/ROCK protein kinase	0.0449	0.245	0.2432
Loa Loa (eye worm)	G-protein coupled receptor	0.0031	0.0071	0.0047
Brugia malayi	putative neuropeptide receptor NPR1	0.0031	0.0071	0.0071
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0057	0.0914
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0061	0.0243	1
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0061	0.0243	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0031	0.0071	0.0047
Plasmodium falciparum	SPRY domain, putative	0.0088	0.0395	1
Trichomonas vaginalis	conserved hypothetical protein	0.0277	0.147	0.3885
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0071	0.0047
Trypanosoma brucei	heat shock protein, putative	0.0037	0.0104	0.367
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0386	0.2088	0.5545
Plasmodium vivax	subtilisin-like serine protease, putative	0.0061	0.0243	0.5914
Trypanosoma cruzi	Heat shock protein 83, putative	0.0037	0.0104	0.3818
Toxoplasma gondii	subtilisin SUB10	0.0061	0.0243	0.6624
Brugia malayi	sulfakinin receptor protein	0.0031	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.1239	0.6938	0.6931
Loa Loa (eye worm)	WD40 repeat protein	0.022	0.1147	0.1126
Schistosoma mansoni	biogenic amine receptor	0.0031	0.0071	0.0047
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0071
Schistosoma mansoni	amine GPCR	0.0031	0.0071	0.0047
Brugia malayi	Dopamine receptor protein 2	0.0031	0.0071	0.0071
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.019	0.0166
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0057	0.0914
Giardia lamblia	Grp94/Hsp90	0.0029	0.0062	0.021
Leishmania major	heat shock protein 83-1	0.0037	0.0104	0.367
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.019	0.0166
Onchocerca volvulus		0.0145	0.0718	0.0652
Leishmania major	heat shock protein 83-1	0.0037	0.0104	0.367
Loa Loa (eye worm)	heat shock protein 90	0.0037	0.0104	0.0081
Brugia malayi	hypothetical protein	0.0278	0.1473	0.1473
Echinococcus multilocularis	neuropeptide Y receptor	0.0031	0.0071	0.0047
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0061	0.0243	0.022
Trypanosoma brucei	heat shock protein, putative	0.0037	0.0104	0.367
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Schistosoma mansoni	amine GPCR	0.0031	0.0071	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Schistosoma mansoni	endoplasmin	0.0037	0.0104	0.0081
Schistosoma mansoni	endoplasmin	0.0037	0.0104	0.0081
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0031	0.0071	0.0047
Brugia malayi	Tubulin beta-1 chain	0.0023	0.0024	0.0024
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0057	0.0904
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0071	0.0047
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.0552	0.053
Schistosoma mansoni	biogenic amine receptor	0.0031	0.0071	0.0047
Schistosoma mansoni	neuropeptide f receptor 76f	0.0031	0.0071	0.0047
Brugia malayi	beta-tubulin, identical	0.0023	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0071	0.0047
Echinococcus multilocularis	g protein coupled receptor	0.0031	0.0071	0.0047
Toxoplasma gondii	subtilisin SUB8	0.0061	0.0243	0.6624
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Schistosoma mansoni	biogenic amine receptor	0.0031	0.0071	0.0047
Schistosoma mansoni	adenoreceptor	0.0031	0.0071	0.0047
Echinococcus multilocularis	endoplasmin	0.0029	0.0062	0.0038
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0386	0.2088	0.5545
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0071	0.0047
Leishmania major	heat shock protein 83-1	0.0037	0.0104	0.367
Brugia malayi	Subtilase family protein	0.0061	0.0243	0.0243
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.1778	1	1
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0678	0.3746	0.3731
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0277	0.147	0.3885
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Echinococcus multilocularis	g protein coupled receptor	0.0031	0.0071	0.0047
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0057	0.1726
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Schistosoma mansoni	microtubule-associated protein tau	0.0781	0.4335	0.4321
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0071	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0243	0.059
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0061	0.0243	1
Echinococcus granulosus	neuropeptides capa receptor	0.0031	0.0071	0.0047
Onchocerca volvulus		0.0061	0.0243	0.0174
Brugia malayi	proprotein convertase 2	0.0947	0.528	0.528
Schistosoma mansoni	neuropeptide F-like receptor	0.0031	0.0071	0.0047
Leishmania major	heat shock protein 83-1	0.0037	0.0104	0.367
Onchocerca volvulus		0.0048	0.0166	0.0096
Trichomonas vaginalis	heat shock protein, putative	0.0029	0.0062	0.0103
Trichomonas vaginalis	conserved hypothetical protein	0.0152	0.0757	0.1972
Echinococcus granulosus	dro:myosuppressin receptor	0.0031	0.0071	0.0047
Trichomonas vaginalis	tubulin gamma chain, putative	0.0023	0.0024	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Echinococcus multilocularis	dro:myosuppressin receptor	0.0031	0.0071	0.0047
Plasmodium falciparum	subtilisin-like protease 1	0.0061	0.0243	0.5919
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0071	0.0047
Schistosoma mansoni	growth hormone secretagogue receptor	0.0031	0.0071	0.0047
Brugia malayi	Protein kinase domain containing protein	0.0449	0.245	0.245
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Trichomonas vaginalis	heat shock protein, putative	0.0029	0.0062	0.0103
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Brugia malayi	neuroendocrine convertase 1 precursor	0.1073	0.5994	0.5994
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0061	0.0243	0.022
Echinococcus multilocularis	neuropeptide receptor A26	0.0031	0.0071	0.0047
Leishmania major	heat shock protein 83-1	0.0037	0.0104	0.367
Schistosoma mansoni	opsin-like receptor	0.0031	0.0071	0.0047
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0071
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0031	0.0071	0.0047
Echinococcus granulosus	Furin 1	0.0386	0.2088	0.2069
Echinococcus granulosus	protein will die slowly	0.022	0.1147	0.1126
Schistosoma mansoni	retinoblastoma binding protein	0.0152	0.0757	0.0735
Trichomonas vaginalis	WD repeat domain, putative	0.022	0.1147	0.3018
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0031	0.0071	0.0047
Onchocerca volvulus	Cell death protein 3 homolog	0.0278	0.1473	0.1413
Schistosoma mansoni	neuropeptide receptor	0.0031	0.0071	0.0047
Brugia malayi	heat shock protein 90	0.0037	0.0104	0.0104
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Trichomonas vaginalis	tubulin, putative	0.0023	0.0024	0.0001
Echinococcus multilocularis	neuropeptide receptor	0.0031	0.0071	0.0047
Toxoplasma gondii	subtilisin SUB12	0.0061	0.0243	0.6624
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.019	0.0166
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0031	0.0071	0.0047
Echinococcus multilocularis	orexin receptor type 2	0.0031	0.0071	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0071
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0071
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0029	0.0062	0.1727
Loa Loa (eye worm)	endoplasmin	0.0037	0.0104	0.0081
Schistosoma mansoni	hypothetical protein	0.1778	1	1
Echinococcus granulosus	enteropeptidase	0.0048	0.0166	0.0143
Trypanosoma brucei	heat shock protein, putative	0.0037	0.0104	0.367
Echinococcus multilocularis	serotonin receptor	0.0031	0.0071	0.0047
Echinococcus granulosus	inhibitor of apoptosis protein	0.1778	1	1
Brugia malayi	MH2 domain containing protein	0.0116	0.0552	0.0552
Brugia malayi	larval opioid receptor	0.0031	0.0071	0.0071
Echinococcus granulosus	neuropeptide Y receptor	0.0031	0.0071	0.0047
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0031	0.0071	0.0047
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0678	0.3746	0.3731
Echinococcus granulosus	Mastin	0.0048	0.0166	0.0143
Leishmania major	heat shock protein 83-1	0.0037	0.0104	0.367
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0031	0.0071	0.0047
Trypanosoma cruzi	heat shock protein 90, putative	0.0037	0.0104	0.3818
Echinococcus granulosus	biogenic amine 5HT receptor	0.0031	0.0071	0.0047
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0278	0.1473	0.1453
Brugia malayi	G protein-coupled receptor F59B2.13	0.0031	0.0071	0.0071
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0181	0.0924	0.0902
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0395	0.0997
Echinococcus granulosus	tm gpcr rhodopsin	0.0031	0.0071	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Echinococcus granulosus	serotonin receptor	0.0031	0.0071	0.0047
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0061	0.0243	1
Schistosoma mansoni	histamine h1 receptor	0.0031	0.0071	0.0047
Echinococcus granulosus	tm gpcr rhodopsin	0.0031	0.0071	0.0047
Brugia malayi	hypothetical protein	0.0029	0.0057	0.0057
Brugia malayi	Cell death protein 3 precursor	0.0278	0.1473	0.1473
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Brugia malayi	putative neuropeptide receptor	0.0031	0.0071	0.0071
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0301	0.1605	0.1585
Brugia malayi	G protein-coupled receptor	0.0031	0.0071	0.0071
Echinococcus multilocularis	somatostatin receptor	0.0031	0.0071	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Brugia malayi	SPRY domain containing protein	0.0088	0.0395	0.0395
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.019	0.0166
Echinococcus multilocularis	g-protein coupled receptor	0.0031	0.0071	0.0047
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0678	0.3746	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0031	0.0071	0.0047
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Loa Loa (eye worm)	hypothetical protein	0.0173	0.0879	0.0858
Schistosoma mansoni	hypothetical protein	0.022	0.1147	0.1126
Echinococcus granulosus	neuropeptide receptor	0.0031	0.0071	0.0047
Toxoplasma gondii	heat shock protein 90, putative	0.0037	0.0104	0.2431
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0678	0.3746	1
Plasmodium falciparum	subtilisin-like protease 3	0.0061	0.0243	0.5919
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0071	0.0047
Echinococcus granulosus	neuropeptide receptor A26	0.0031	0.0071	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0395	0.0997
Brugia malayi	Furin-like cysteine rich region family protein	0.0181	0.0924	0.0924
Echinococcus granulosus	neuropeptide FF receptor 2	0.0031	0.0071	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1473	0.1453
Echinococcus granulosus	wd40 repeat	0.0152	0.0757	0.0735
Trichomonas vaginalis	tubulin beta chain, putative	0.0023	0.0024	0.0001
Trypanosoma brucei	heat shock protein 90, putative	0.0037	0.0104	0.367
Echinococcus granulosus	orexin receptor type 2	0.0031	0.0071	0.0047
Echinococcus granulosus	G protein coupled receptor 139	0.0031	0.0071	0.0047
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.1239	0.6938	0.6931
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0061	0.0243	0.022
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0031	0.0071	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0243	0.059
Echinococcus granulosus	hypothetical protein	0.0031	0.0071	0.0047
Trypanosoma cruzi	heat shock protein 85, putative	0.0037	0.0104	0.3818
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0355	0.089
Trichomonas vaginalis	conserved hypothetical protein	0.0277	0.147	0.3885
Brugia malayi	endoprotease bli-4 precursor	0.1239	0.6938	0.6938
Echinococcus multilocularis	G protein coupled receptor 139	0.0031	0.0071	0.0047
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.019	0.0166
Brugia malayi	Serotonin receptor	0.0031	0.0071	0.0071
Schistosoma mansoni	opsin-like receptor	0.0031	0.0071	0.0047
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0031	0.0071	0.0047
Echinococcus multilocularis	sex peptide receptor	0.0031	0.0071	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0277	0.147	0.3885
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0386	0.2088	0.5545
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Echinococcus multilocularis		0.0962	0.5364	0.5353
Echinococcus granulosus	baculoviral IAP repeat containing protein	0.1778	1	1
Brugia malayi	Dopamine receptor	0.0031	0.0071	0.0071
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0031	0.0071	0.0047
Brugia malayi	follicle stimulating hormone receptor	0.0031	0.0071	0.0071
Leishmania major	heat shock protein 83-1	0.0037	0.0104	0.367
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0071	0.0047
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0061	0.0243	0.0243
Schistosoma mansoni	amine GPCR	0.0031	0.0071	0.0047
Echinococcus multilocularis	neuropeptides capa receptor	0.0031	0.0071	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0609	0.3358	0.3342
Echinococcus multilocularis	heat shock protein 90	0.0037	0.0104	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Schistosoma mansoni	hypothetical protein	0.0031	0.0071	0.0047
Trypanosoma brucei	heat shock protein, putative	0.0037	0.0104	0.367
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0031	0.0071	0.0047
Loa Loa (eye worm)	endoprotease bli-4	0.1239	0.6938	0.6931
Echinococcus multilocularis	neuropeptide receptor	0.0031	0.0071	0.0047
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0031	0.0071	0.0047
Trichomonas vaginalis	tubulin alpha chain, putative	0.0023	0.0024	0.0001
Schistosoma mansoni	amine GPCR	0.0031	0.0071	0.0047
Echinococcus granulosus	epidermal growth factor receptor	0.0181	0.0924	0.0902
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0071	0.0047
Brugia malayi	RE15519p	0.0031	0.0071	0.0071
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0071	0.0047
Echinococcus multilocularis	Mastin	0.0048	0.0166	0.0143
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0031	0.0071	0.0047
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Schistosoma mansoni	serine/threonine protein kinase	0.0145	0.0718	0.0695
Trichomonas vaginalis	conserved hypothetical protein	0.0277	0.147	0.3885
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0057	0.0034
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0109	0.0513	0.0491
Leishmania major	hypothetical protein, conserved	0.0029	0.0057	0.1528
Echinococcus granulosus	rho-associated protein kinase 1	0.0145	0.0718	0.0695
Trypanosoma brucei	heat shock protein 90, putative	0.0037	0.0104	0.367
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0031	0.0071	0.0047
Plasmodium vivax	subtilisin-like protease 1	0.0061	0.0243	0.5914
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Loa Loa (eye worm)	SPRY domain-containing protein	0.0088	0.0395	0.0371
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0061	0.0243	1
Echinococcus granulosus	somatostatin receptor	0.0031	0.0071	0.0047
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0071	0.0047
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0031	0.0071	0.0047
Brugia malayi	celfurPC protein	0.0962	0.5364	0.5364
Echinococcus multilocularis	neuroendocrine convertase 2	0.0947	0.528	0.5269
Brugia malayi	G-protein coupled receptor	0.0031	0.0071	0.0071
Echinococcus multilocularis	Furin 1	0.0386	0.2088	0.2069
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0243	0.022
Plasmodium vivax	hypothetical protein, conserved	0.0088	0.0395	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Echinococcus granulosus	apoptotic protease activating factor 1	0.0278	0.1473	0.1453
Echinococcus granulosus	glycoprotein Antigen 5	0.0048	0.0166	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0061	0.0243	1
Trypanosoma cruzi	subtilisin peptidase	0.0061	0.0243	1
Trypanosoma brucei	heat shock protein, putative	0.0037	0.0104	0.367
Loa Loa (eye worm)	subtilase	0.0061	0.0243	0.022
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0071
Leishmania major	heat shock protein 83-1	0.0037	0.0104	0.367
Trypanosoma cruzi	heat shock protein 90, putative	0.0029	0.0062	0.192
Schistosoma mansoni	neuropeptide F-like receptor	0.0031	0.0071	0.0047
Echinococcus granulosus	g protein coupled receptor	0.0031	0.0071	0.0047
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0031	0.0071	0.0071
Echinococcus multilocularis	glycoprotein Antigen 5	0.0048	0.0166	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Echinococcus granulosus	neuropeptides capa receptor	0.0031	0.0071	0.0047
Trypanosoma brucei	Heat shock protein 83, putative	0.0037	0.0104	0.367
Leishmania major	heat shock protein 83-1	0.0037	0.0104	0.367
Echinococcus multilocularis	fmrfamide receptor	0.0031	0.0071	0.0047
Brugia malayi	ORL1-like opioid receptor	0.0031	0.0071	0.0071
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0278	0.1473	0.1453
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.019	0.0166
Loa Loa (eye worm)	SPRY domain-containing protein	0.0081	0.0355	0.0332
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.019	0.0166
Brugia malayi	AKH receptor	0.0031	0.0071	0.0071
Brugia malayi	G-protein coupled receptor	0.0031	0.0071	0.0071
Echinococcus granulosus	g protein coupled receptor	0.0031	0.0071	0.0047
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0031	0.0071	0.0047
Schistosoma mansoni	heat shock protein	0.0037	0.0104	0.0081
Echinococcus granulosus	heat shock protein 90	0.0029	0.0062	0.0038
Onchocerca volvulus		0.022	0.1147	0.1084
Loa Loa (eye worm)	melatonin receptor type 1A	0.0031	0.0071	0.0047
Onchocerca volvulus		0.0144	0.0716	0.065
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Echinococcus granulosus	g-protein coupled receptor	0.0031	0.0071	0.0047
Brugia malayi	GnHR receptor homolog	0.0031	0.0071	0.0071
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0061	0.0243	0.022
Leishmania major	subtilisin-like serine peptidase	0.0061	0.0243	1
Leishmania major	heat shock protein 83-1	0.0037	0.0104	0.367
Echinococcus granulosus	endoplasmin	0.0029	0.0062	0.0038
Echinococcus granulosus	biogenic amine 5HT receptor	0.0031	0.0071	0.0047
Echinococcus granulosus	sex peptide receptor	0.0031	0.0071	0.0047
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0031	0.0071	0.0047
Trichomonas vaginalis	heat shock protein, putative	0.0029	0.0062	0.0103
Echinococcus granulosus	7TM GPCR rhodopsin	0.0031	0.0071	0.0047
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0071	0.0047
Echinococcus multilocularis	g protein coupled receptor	0.0031	0.0071	0.0047
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0386	0.2088	0.5545
Plasmodium falciparum	subtilisin-like protease 2	0.0061	0.0243	0.5919
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.0552	0.053
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0031	0.0071	0.0047
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0031	0.0071	0.0047
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0031	0.0071	0.0047
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0061	0.0243	0.022
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0071	0.0047
Trichomonas vaginalis	retinoblastoma binding protein, putative	0.0152	0.0757	0.1972
Schistosoma mansoni	neuropeptide receptor	0.0031	0.0071	0.0047
Echinococcus granulosus	allatostatin A receptor	0.0031	0.0071	0.0047
Echinococcus granulosus	set1:ash2 histone methyltransferase complex	0.0088	0.0395	0.0371
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0061	0.0243	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0029	0.0062	0.192
Plasmodium falciparum	tubulin beta chain	0.0023	0.0024	0.0011
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0071	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0277	0.147	0.3885
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0031	0.0071	0.0047
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0031	0.0071	0.0047
Schistosoma mansoni	neuropeptide receptor	0.0031	0.0071	0.0047
Echinococcus granulosus	membrane bound transcription factor site 1	0.0061	0.0243	0.022
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0071
Treponema pallidum	heat shock protein 90	0.0029	0.0062	0.5
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0031	0.0071	0.0047
Echinococcus multilocularis	protein will die slowly	0.022	0.1147	0.1126
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0031	0.0071	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Onchocerca volvulus		0.1778	1	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Brugia malayi	Hypothetical WD-repeat protein F21H12.1 in chromosome II	0.0152	0.0757	0.0757
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0243	0.059
Toxoplasma gondii	subtilisin SUB7	0.0061	0.0243	0.6624
Onchocerca volvulus	Deterin homolog	0.1778	1	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0165	0.0381
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0031	0.0071	0.0047
Echinococcus multilocularis	neuropeptide Y receptor	0.0031	0.0071	0.0047
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0031	0.0071	0.0047
Echinococcus multilocularis	heat shock protein 90	0.0029	0.0062	0.0038
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0031	0.0071	0.0047
Echinococcus multilocularis	enteropeptidase	0.0048	0.0166	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0023	0.0024	0.0001
Echinococcus granulosus	neuropeptide Y receptor	0.0031	0.0071	0.0047
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Echinococcus multilocularis	allatostatin A receptor	0.0031	0.0071	0.0047
Echinococcus granulosus	neuropeptide s receptor	0.0031	0.0071	0.0047
Toxoplasma gondii	subtilisin SUB4	0.0061	0.0243	0.6624
Loa Loa (eye worm)	G-protein coupled receptor	0.0031	0.0071	0.0047
Leishmania major	heat shock protein 83-1	0.0037	0.0104	0.367
Schistosoma mansoni	furin-1 (S08 family)	0.0623	0.3435	0.342
Schistosoma mansoni	amine GPCR	0.0031	0.0071	0.0047
Toxoplasma gondii	SPRY domain-containing protein	0.0081	0.0355	1
Schistosoma mansoni	neuropeptide receptor	0.0031	0.0071	0.0047
Schistosoma mansoni	caspase-7 (C14 family)	0.0278	0.1473	0.1453
Loa Loa (eye worm)	proprotein convertase 2	0.0386	0.2088	0.2069
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0031	0.0071	0.0047
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0031	0.0071	0.0071
Brugia malayi	neuropeptide F receptor	0.0031	0.0071	0.0071
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0071	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Schistosoma mansoni	hypothetical protein	0.0277	0.147	0.1449
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0061	0.0243	1
Leishmania major	heat shock protein 83-1	0.0037	0.0104	0.367
Trichomonas vaginalis	conserved hypothetical protein	0.0277	0.147	0.3885
Echinococcus granulosus	neuropeptide receptor	0.0031	0.0071	0.0047
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0061	0.0243	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0031	0.0071	0.0047
Loa Loa (eye worm)	hypothetical protein	0.1778	1	1
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0325	0.174	0.4611
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0048	0.0166	0.0143
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0023	0.0024	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Loa Loa (eye worm)	neuropeptide F receptor	0.0031	0.0071	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0277	0.147	0.3885
Trypanosoma cruzi	beta tubulin, putative	0.0023	0.0024	0.0233
Brugia malayi	Endoplasmin precursor	0.0037	0.0104	0.0104
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0029	0.0062	0.0038
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Echinococcus granulosus	furin	0.1239	0.6938	0.6931
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0071
Toxoplasma gondii	subtilisin SUB2	0.0061	0.0243	0.6624
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0031	0.0071	0.0047
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0037	0.0104	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Leishmania major	heat shock protein 83-1	0.0037	0.0104	0.367
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0071	0.0047
Trypanosoma brucei	subtilisin peptidase	0.0061	0.0243	1
Toxoplasma gondii	heat shock protein HSP90	0.0037	0.0104	0.2431
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0031	0.0071	0.0047
Brugia malayi	hypothetical protein	0.0031	0.0071	0.0071
Leishmania major	heat shock protein 83-1	0.0037	0.0104	0.367
Trypanosoma brucei	heat shock protein, putative	0.0037	0.0104	0.367
Echinococcus multilocularis	neuropeptides capa receptor	0.0031	0.0071	0.0047
Brugia malayi	Melatonin receptor type 1A	0.0031	0.0071	0.0071
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0031	0.0071	0.0047
Toxoplasma gondii	subtilisin SUB5	0.0061	0.0243	0.6624
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0031	0.0071	0.0047
Echinococcus multilocularis	inhibitor of apoptosis protein	0.1778	1	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Plasmodium vivax	heat shock protein 86, putative	0.0037	0.0104	0.2171
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0031	0.0071	0.0047
Schistosoma mansoni	inhibitor of apoptosis (iap) domain family member	0.1778	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.019	0.0166
Echinococcus multilocularis	microtubule associated protein 2	0.0781	0.4335	0.4321
Schistosoma mansoni	heat shock protein	0.0037	0.0104	0.0081
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0031	0.0071	0.0071
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0061	0.0243	1
Trichomonas vaginalis	hypothetical protein	0.0277	0.147	0.3885
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Mycobacterium leprae	Possible secreted protease	0.0061	0.0243	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0325	0.174	0.4611
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0061	0.0243	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0031	0.0071	0.0047
Schistosoma mansoni	opsin-like receptor	0.0031	0.0071	0.0047
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0031	0.0071	0.0047
Entamoeba histolytica	heat shock protein 90, putative	0.0037	0.0104	1
Echinococcus multilocularis	heat shock protein	0.0037	0.0104	0.0081
Echinococcus multilocularis	fmrfamide receptor	0.0031	0.0071	0.0047
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0061	0.0243	0.059
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0243	0.059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0031	0.0071	0.0047
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0031	0.0071	0.0047
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0031	0.0071	0.0047
Plasmodium falciparum	heat shock protein 90	0.0037	0.0104	0.2179
Echinococcus multilocularis	wd40 repeat	0.0152	0.0757	0.0735
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0061	0.0243	0.022
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0071	0.0047
Schistosoma mansoni	tyrosine kinase	0.0181	0.0924	0.0902

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		Agonist activity at Myc-tagged delta-type opioid receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by liquid scintillation counting analysis	ChEMBL.	23477419
EC50 (functional)	= 0.00853 nM	Agonist activity at FLAG-tagged mu-type opioid receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by liquid scintillation counting analysis	ChEMBL.	23477419
Emax (functional)	= 96.2 %	Agonist activity at FLAG-tagged mu-type opioid receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by liquid scintillation counting analysis relative to DAMGO	ChEMBL.	23477419
IC50 (binding)	= 1.67 nM	Agonist activity at mu-type opioid receptor in guinea pig ileum assessed as inhibition of electrically evoked muscle contraction	ChEMBL.	23477419
IC50 (binding)	= 2.91 nM	Agonist activity at mu-type opioid receptor in Kunming mouse vas deferens assessed as inhibition of electrically evoked muscle contraction	ChEMBL.	23477419
Inhibition (binding)		Agonist activity at mu-type opioid receptor in Kunming mouse vas deferens assessed as inhibition of electrically evoked muscle contraction in presence of naltrindole	ChEMBL.	23477419
Ki (binding)	= 0.165 nM	Displacement of [3H]DAMGO from FLAG-tagged mu-type opioid receptor (unknown origin) expressed in HEK293 cells after 60 mins by liquid scintillation counting analysis	ChEMBL.	23477419
Ki (binding)	= 2780 nM	Displacement of [3H]DPDPE from Myc-tagged delta-type opioid receptor (unknown origin) expressed in HEK293 cells after 60 mins by liquid scintillation counting analysis	ChEMBL.	23477419

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2334771

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1732298