Detailed information for compound 1735825

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 334.393 | Formula: C15H18N4O3S
  • H donors: 4 H acceptors: 3 LogP: 1.51 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cc(C)cc(c1)C)Nc1ccc(cc1)NS(=O)(=O)N
  • InChi: 1S/C15H18N4O3S/c1-10-7-11(2)9-14(8-10)18-15(20)17-12-3-5-13(6-4-12)19-23(16,21)22/h3-9,19H,1-2H3,(H2,16,21,22)(H2,17,18,20)
  • InChiKey: HYJDBNCSABGIPG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens carbonic anhydrase IX Starlite/ChEMBL References
Candida glabrata CBS 138 Carbonic anhydrase Starlite/ChEMBL References
Candida albicans Involved in protection against oxidative damage Starlite/ChEMBL References
Homo sapiens carbonic anhydrase II Starlite/ChEMBL References
Homo sapiens carbonic anhydrase I Starlite/ChEMBL References
Homo sapiens carbonic anhydrase XII Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis carbonic anhydrase family protein, putative Get druggable targets OG5_127503 All targets in OG5_127503
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) Get druggable targets OG5_127503 All targets in OG5_127503
Candida albicans Involved in protection against oxidative damage Get druggable targets OG5_127503 All targets in OG5_127503
Candida albicans Involved in protection against oxidative damage Get druggable targets OG5_127503 All targets in OG5_127503
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127503 All targets in OG5_127503
Leishmania major carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania braziliensis carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase Get druggable targets OG5_127503 All targets in OG5_127503
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Putative carbonic anhydrase 5 precursor Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania infantum carbonic anhydrase family protein, putative Get druggable targets OG5_127503 All targets in OG5_127503
Leishmania donovani carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei gambiense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania donovani carbonic anhydrase family protein, putative Get druggable targets OG5_127503 All targets in OG5_127503
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Mycobacterium ulcerans carbonic anhydrase Get druggable targets OG5_127503 All targets in OG5_127503
Leishmania infantum carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus multilocularis carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania major carbonic anhydrase family protein, putative Get druggable targets OG5_127503 All targets in OG5_127503
Echinococcus granulosus carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania mexicana carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Entamoeba histolytica carbonic anhydrase, putative Get druggable targets OG5_127503 All targets in OG5_127503
Leishmania mexicana carbonic anhydrase family protein, putative Get druggable targets OG5_127503 All targets in OG5_127503
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB Get druggable targets OG5_127503 All targets in OG5_127503
Brugia malayi Eukaryotic-type carbonic anhydrase family protein Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) carbonic anhydrase 3 Get druggable targets OG5_127628 All targets in OG5_127628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei carbonic anhydrase-like protein carbonic anhydrase I 261 aa 281 aa 25.3 %
Brugia malayi Carbonic anhydrase like protein 2 precursor carbonic anhydrase II 260 aa 259 aa 32.0 %
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) Carbonic anhydrase   219 aa 199 aa 25.6 %
Trypanosoma cruzi carbonic anhydrase-like protein, putative carbonic anhydrase XII 354 aa 295 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Flap endonuclease-1 0.0029 0.0247 0.0727
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0019 0.0128 0.0111
Plasmodium vivax small ubiquitin-related modifier, putative 0.0043 0.042 0.4303
Schistosoma mansoni acetyl-CoA synthetase 0.003 0.0261 0.0251
Loa Loa (eye worm) hypothetical protein 0.0194 0.2196 0.6463
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.003 0.0261 0.0467
Plasmodium vivax acetyl-CoA synthetase, putative 0.003 0.0261 0.1963
Echinococcus granulosus carbonic anhydrase II 0.0248 0.2831 0.2796
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.0247 0.0237
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.035 0.0923
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.012 0.1329 0.1288
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0159 0.1784 0.1745
Leishmania major DNA polymerase eta, putative 0.0026 0.0217 0.0189
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.0019 0.0128 0.0319
Onchocerca volvulus 0.0157 0.1761 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.003 0.0261 0.0215
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.1491 0.1482
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0016 0.0098 0.0108
Schistosoma mansoni cpg binding protein 0.0064 0.0658 0.0648
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0098 0.0288
Brugia malayi acetyl-Coenzyme A synthetase 2 0.003 0.0261 0.0768
Schistosoma mansoni carbonic anhydrase 0.0134 0.1491 0.1482
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0342 0.1007
Brugia malayi hypothetical protein 0.0194 0.2196 0.6463
Mycobacterium ulcerans acyl-CoA synthetase 0.0102 0.1109 0.1605
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.035 0.103
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0098 0.021
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.035 0.1062
Brugia malayi AMP-binding enzyme family protein 0.0102 0.1109 0.3264
Onchocerca volvulus 0.0037 0.035 0.1359
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0019 0.0128 0.0081
Brugia malayi N-terminal motif family protein 0.015 0.1678 0.4937
Entamoeba histolytica acetyltransferase, GNAT family 0.0032 0.0292 0.0307
Trypanosoma cruzi P-type H+-ATPase, putative 0.0019 0.0128 0.0111
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0019 0.0128 0.0048
Echinococcus multilocularis dna polymerase kappa 0.0016 0.0098 0.0051
Plasmodium falciparum pyruvate kinase 0.0037 0.0342 0.157
Schistosoma mansoni copper ABC transporter ATPase 0.0019 0.0128 0.0118
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0342 0.131
Schistosoma mansoni DNA polymerase eta 0.0037 0.0347 0.0337
Giardia lamblia Sentrin 0.0043 0.042 1
Echinococcus multilocularis flap endonuclease 1 0.0029 0.0247 0.0201
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0019 0.0128 0.0048
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0019 0.0128 0.0087
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0342 0.0388
Brugia malayi acetyltransferase, GNAT family protein 0.012 0.1329 0.391
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.035 0.1062
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.035 0.103
Schistosoma mansoni atpase class VI type 11c 0.0019 0.0128 0.0118
Loa Loa (eye worm) hypothetical protein 0.0037 0.035 0.103
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0211 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0098 0.021
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0019 0.0128 0.0319
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.035 0.0722
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0757 0.1885
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.003 0.0261 0.0215
Leishmania major DNA polymerase eta, putative 0.0037 0.0347 0.0396
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0218 0.1323
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0076 0.0806 0.2026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0757 0.1885
Trypanosoma cruzi phospholipid-transporting ATPase-like protein, putative 0.0019 0.0128 0.0111
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.2729 0.7529
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0261 0.0259
Mycobacterium tuberculosis Cation transporter P-type ATPase a CtpA 0.0019 0.0128 0.0087
Plasmodium falciparum histone acetyltransferase GCN5 0.0032 0.0292 0.1199
Trypanosoma cruzi small ubiquitin protein, putative 0.0043 0.042 0.1178
Leishmania major copper-transporting ATPase-like protein, putative 0.0019 0.0128 0.0048
Brugia malayi hypothetical protein 0.0019 0.0128 0.0377
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.1491 0.1482
Echinococcus multilocularis 0.0092 0.0989 0.0946
Brugia malayi AMP-binding enzyme family protein 0.003 0.0261 0.0768
Echinococcus multilocularis phosphoserine phosphatase 0.0019 0.0128 0.0081
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0019 0.0128 0.0223
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0069 0.000000000075658
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0035 0.0326 0.1455
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.0247 0.0546
Loa Loa (eye worm) hypothetical protein 0.0037 0.0347 0.1022
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0019 0.0128 0.0319
Brugia malayi AMP-binding enzyme family protein 0.003 0.0261 0.0768
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0342 0.0894
Schistosoma mansoni tyrosine kinase 0.0157 0.1764 0.1755
Trichomonas vaginalis cation-transporting ATPase, putative 0.0019 0.0128 0.0223
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0019 0.0128 0.0111
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.035 0.1114
Echinococcus multilocularis cation transporting atpase worm 0.0019 0.0128 0.0081
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.003 0.0261 0.0259
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.0019 0.0128 0.0048
Schistosoma mansoni hypothetical protein 0.0856 1 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0035 0.0326 0.1455
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.003 0.0261 0.0598
Loa Loa (eye worm) calcium ATPase 0.0019 0.0128 0.0377
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0098 0.021
Brugia malayi beta-lactamase 0.0037 0.035 0.103
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0098 0.021
Echinococcus multilocularis cpg binding protein 0.0064 0.0658 0.0613
Loa Loa (eye worm) hypothetical protein 0.003 0.0261 0.0768
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0218 0.0439
Brugia malayi AMP-binding enzyme family protein 0.003 0.0261 0.0768
Loa Loa (eye worm) TK/INSR protein kinase 0.0095 0.1024 0.3013
Mycobacterium ulcerans metal cation-transporting p-type ATPase CtpC 0.0019 0.0128 0.0048
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.035 0.034
Trichomonas vaginalis cation-transporting ATPase, putative 0.0019 0.0128 0.0223
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0128 0.0081
Mycobacterium ulcerans lipase LipD 0.0037 0.035 0.04
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.003 0.0261 0.0467
Trichomonas vaginalis cation-transporting ATPase, putative 0.0019 0.0128 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0098 0.021
Echinococcus granulosus geminin 0.0191 0.2159 0.2121
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0125 0.0368
Brugia malayi hypothetical protein 0.0026 0.0218 0.0641
Brugia malayi E1-E2 ATPase family protein 0.0019 0.0128 0.0377
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0085 0.0038
Giardia lamblia Pyruvate kinase 0.0019 0.0131 0.1036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0261 0.0467
Loa Loa (eye worm) hypothetical protein 0.0026 0.0211 0.0621
Echinococcus granulosus copper transporting ATPase 1 0.0019 0.0128 0.0081
Echinococcus multilocularis copper transporting ATPase 1 0.0019 0.0128 0.0081
Giardia lamblia Copper-transporting P-type ATPase 0.0019 0.0128 0.0942
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.1491 0.4387
Echinococcus granulosus pyruvate kinase 0.0037 0.0342 0.0296
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0377
Loa Loa (eye worm) hypothetical protein 0.0102 0.1109 0.3264
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.003 0.0261 0.0795
Leishmania major hypothetical protein, conserved 0.0037 0.035 0.04
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.035 0.1062
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0019 0.0128 0.0118
Schistosoma mansoni hypothetical protein 0.0191 0.2159 0.215
Onchocerca volvulus 0.0037 0.035 0.1359
Mycobacterium ulcerans hypothetical protein 0.0037 0.035 0.04
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0248 0.2831 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.1491 0.4387
Trichomonas vaginalis conserved hypothetical protein 0.0238 0.2715 1
Plasmodium falciparum flap endonuclease 1 0.0029 0.0247 0.0873
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.003 0.0261 0.0212
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.035 0.0722
Echinococcus multilocularis phosphoserine phosphatase 0.0019 0.0128 0.0081
Loa Loa (eye worm) carbonic anhydrase 3 0.0248 0.2831 0.8329
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.035 0.0722
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0019 0.0128 0.0223
Schistosoma mansoni cation-transporting ATPase 0.0019 0.0128 0.0118
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0019 0.0128 0.0942
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0134 0.1491 0.4387
Schistosoma mansoni cation-transporting atpase worm 0.0019 0.0128 0.0118
Loa Loa (eye worm) hypothetical protein 0.0037 0.0342 0.1007
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.003 0.0261 0.0976
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.042 0.1324
Echinococcus multilocularis pyruvate kinase 0.0037 0.0342 0.0296
Plasmodium vivax flap endonuclease 1, putative 0.0029 0.0247 0.1755
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.003 0.0261 0.0259
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0377
Mycobacterium ulcerans acyl-CoA synthetase 0.0102 0.1109 0.1605
Echinococcus granulosus flap endonuclease 1 0.0029 0.0247 0.0201
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0212 0.0327
Echinococcus multilocularis phosphoserine phosphatase 0.0019 0.0128 0.0081
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0019 0.0128 0.0223
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0069 0.000000000075658
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0095 0.1024 0.0981
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0102 0.1109 0.1564
Loa Loa (eye worm) E1-E2 ATPase 0.0019 0.0128 0.0377
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.003 0.0261 0.0259
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0019 0.0128 0.0048
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.035 0.1062
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0019 0.0128 0.0081
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.035 0.0722
Brugia malayi Furin-like cysteine rich region family protein 0.0296 0.3399 1
Schistosoma mansoni tyrosine kinase 0.0296 0.3399 0.3392
Toxoplasma gondii hypothetical protein 0.0134 0.1491 1
Echinococcus multilocularis carbonic anhydrase 0.0134 0.1491 0.1451
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0076 0.0806 0.1123
Loa Loa (eye worm) hypothetical protein 0.0134 0.1491 0.4387
Schistosoma mansoni tyrosine kinase 0.0159 0.1784 0.1775
Brugia malayi E1-E2 ATPase family protein 0.0019 0.0128 0.0377
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0342 0.1086
Plasmodium falciparum acetyl-CoA synthetase, putative 0.003 0.0261 0.0976
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0248 0.2831 0.8329
Mycobacterium ulcerans hypothetical protein 0.0102 0.1109 0.1605
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.003 0.0261 0.0259
Mycobacterium tuberculosis Conserved protein 0.0037 0.035 0.0722
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0019 0.0128 0.0118
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.0247 0.0745
Echinococcus granulosus cation transporting ATPase 13A1 0.0019 0.0128 0.0081
Mycobacterium ulcerans metal cation transporter p-type ATPase, CtpV 0.0019 0.0128 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.035 0.0923
Plasmodium vivax hypothetical protein, conserved 0.0037 0.035 0.3277
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0019 0.0128 0.0048
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0342 0.157
Trichomonas vaginalis ubiquitin, putative 0.0027 0.0224 0.0586
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.1491 0.1482
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0342 0.0699
Echinococcus multilocularis pyruvate kinase 0.0029 0.0251 0.0204
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0019 0.0128 0.0223
Leishmania major hypothetical protein, conserved 0.0026 0.0218 0.019
Trypanosoma brucei unspecified product 0.0016 0.0098 0.021
Schistosoma mansoni pyruvate kinase 0.0019 0.0131 0.0121
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0019 0.0128 0.0377
Brugia malayi Na,K-ATPase alpha subunit 0.0019 0.0128 0.0377
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0102 0.1109 0.1605
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0019 0.0128 0.0081
Giardia lamblia Histone acetyltransferase GCN5 0.0032 0.0292 0.6021
Brugia malayi hypothetical protein 0.0157 0.1761 0.5183
Mycobacterium ulcerans carbonic anhydrase 0.0238 0.2715 0.4154
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0342 0.1007
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0261 0.0467
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0342 0.1031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0377
Schistosoma mansoni carbonic anhydrase 0.0551 0.6399 0.6395
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.035 0.0304
Loa Loa (eye worm) hypothetical protein 0.0037 0.035 0.103
Giardia lamblia Pyruvate kinase 0.0037 0.0342 0.7591
Loa Loa (eye worm) hypothetical protein 0.0076 0.0806 0.2371
Entamoeba histolytica acyl-CoA synthetase, putative 0.0102 0.1109 0.1605
Trichomonas vaginalis cation-transporting ATPase, putative 0.0019 0.0128 0.0223
Leishmania major pyruvate kinase 0.0037 0.0342 0.0388
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0019 0.0128 0.0377
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0248 0.2831 0.2823
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0098 0.0088
Mycobacterium ulcerans cation-transporter p-type ATPase B CtpB 0.0019 0.0128 0.0048
Echinococcus multilocularis epidermal growth factor receptor 0.0296 0.3399 0.3367
Leishmania major carbonic anhydrase-like protein 0.0248 0.2831 0.4337
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0098 0.021
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.003 0.0261 0.0212
Echinococcus granulosus pyruvate kinase 0.0037 0.0342 0.0296
Echinococcus granulosus histone acetyltransferase KAT2B 0.0117 0.1289 0.1248
Loa Loa (eye worm) hypothetical protein 0.0026 0.0218 0.0641
Schistosoma mansoni cation-transporting atpase worm 0.0019 0.0128 0.0118
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0134 0.1491 0.4387
Entamoeba histolytica hypothetical protein 0.0027 0.0224 0.0201
Loa Loa (eye worm) hypothetical protein 0.015 0.1678 0.4937
Echinococcus granulosus pyruvate kinase 0.0019 0.0131 0.0084
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0248 0.2831 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0296 0.3399 1
Brugia malayi AMP-binding enzyme family protein 0.0102 0.1109 0.3264
Entamoeba histolytica carbonic anhydrase, putative 0.0551 0.6399 1
Echinococcus granulosus pyruvate kinase 0.0019 0.0131 0.0084
Echinococcus multilocularis Small ubiquitin modifier 2 0.0043 0.042 0.0374
Schistosoma mansoni eyes absent homolog 0.0194 0.2196 0.2188
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0218 0.0658
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.003 0.0261 0.0212
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0377
Echinococcus multilocularis epidermal growth factor receptor 0.0159 0.1784 0.1745
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0019 0.0128 0.0048
Trichomonas vaginalis DNA polymerase eta, putative 0.0016 0.0098 0.0108
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0085 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0224 0.0586
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0218 0.064
Echinococcus granulosus phospholipid transporting ATPase VA 0.0019 0.0128 0.0081
Entamoeba histolytica Flap nuclease, putative 0.0029 0.0247 0.0237
Trichomonas vaginalis cation-transporting ATPase, putative 0.0019 0.0128 0.0223
Echinococcus multilocularis pyruvate kinase 0.0019 0.0131 0.0084
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0085 0.0038
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.0247 0.0873
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0131 0.0022
Loa Loa (eye worm) SMO-1 protein 0.0043 0.042 0.1235
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.003 0.0261 0.0976
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0312 0.3592 1
Schistosoma mansoni ATPase 0.0019 0.0128 0.0118
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0019 0.0128 0.0377
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0342 0.131
Loa Loa (eye worm) hypothetical protein 0.0102 0.1109 0.3264
Schistosoma mansoni phosphoserine phosphatase 0.0019 0.0128 0.0118
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0757 0.1885
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0342 0.1086
Echinococcus multilocularis carbonic anhydrase II 0.0248 0.2831 0.2796
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0019 0.0128 0.0319
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0347 0.0913
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.003 0.0261 0.0259
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0098 0.021
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0261 0.0259
Echinococcus granulosus carbonic anhydrase 0.0134 0.1491 0.1451
Echinococcus granulosus dna polymerase kappa 0.0016 0.0098 0.0051
Schistosoma mansoni flap endonuclease-1 0.0026 0.0215 0.0204
Trypanosoma cruzi DNA polymerase eta, putative 0.0026 0.0217 0.0436
Trypanosoma brucei P-type H+-ATPase, putative 0.0019 0.0128 0.0319
Mycobacterium ulcerans acyl-CoA synthetase 0.0102 0.1109 0.1605
Leishmania major 4-coumarate:coa ligase-like protein 0.0102 0.1109 0.1605
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0757 0.1885
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0102 0.1109 0.1564
Mycobacterium tuberculosis Probable cation transporter P-type ATPase D CtpD 0.0019 0.0128 0.0087
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0342 0.0341
Loa Loa (eye worm) hypothetical protein 0.0037 0.035 0.103
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0102 0.1109 0.1605
Mycobacterium ulcerans acetyl-CoA synthetase 0.003 0.0261 0.0259
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0085 0.0038
Mycobacterium leprae Probable lipase LipE 0.0037 0.035 0.0354
Trypanosoma cruzi P-type H+-ATPase, putative 0.0019 0.0128 0.0111
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.0247 0.4637
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0098 0.021
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0019 0.0128 0.0081
Onchocerca volvulus 0.003 0.0261 0.0815
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.003 0.0261 0.0259
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.0247 0.0672
Trypanosoma cruzi copper-transporting ATPase, putative 0.0019 0.0128 0.0111
Loa Loa (eye worm) hypothetical protein 0.0076 0.0806 0.2371
Echinococcus granulosus Small ubiquitin modifier 2 0.0043 0.042 0.0374
Brugia malayi AMP-binding enzyme family protein 0.003 0.0261 0.0768
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.003 0.0261 0.0259
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0098 0.0288
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0019 0.0128 0.0048
Schistosoma mansoni cpg binding protein 0.006 0.0617 0.0608
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0128 0.0376
Loa Loa (eye worm) hypothetical protein 0.0019 0.0128 0.0377
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0043 0.042 0.041
Trichomonas vaginalis bromodomain-containing protein, putative 0.0035 0.0326 0.0972
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0035 0.0326 0.0972
Leishmania major acetyl-CoA synthetase, putative 0.003 0.0261 0.0259
Leishmania major 4-coumarate:coa ligase-like protein 0.0102 0.1109 0.1605
Onchocerca volvulus 0.0102 0.1109 0.6007
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0019 0.0128 0.0223
Onchocerca volvulus 0.003 0.0261 0.0815
Trichomonas vaginalis antibiotic synthetase, putative 0.003 0.0261 0.0725
Schistosoma mansoni cpg binding protein 0.0064 0.0658 0.0648
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0069 0.000000000075658
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.003 0.0261 0.0768
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0019 0.0128 0.0223
Echinococcus multilocularis pyruvate kinase 0.0037 0.0342 0.0296
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0019 0.0128 0.0048
Schistosoma mansoni tyrosine kinase 0.0159 0.1784 0.1775
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0261 0.0259
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0098 0.0051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0069 0.000000000075658
Echinococcus multilocularis pyruvate kinase 0.0019 0.0131 0.0084
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0019 0.0128 0.0081
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0098 0.021
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.003 0.0261 0.0598
Echinococcus granulosus cpg binding protein 0.0064 0.0658 0.0613
Schistosoma mansoni tyrosine kinase 0.0157 0.1764 0.1755
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0019 0.0128 0.0111
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0019 0.0128 0.0111
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.035 0.1062
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0134 0.1491 0.4387
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0248 0.2831 0.8329
Echinococcus multilocularis phosphoserine phosphatase 0.0019 0.0128 0.0081
Echinococcus multilocularis carbonic anhydrase 0.0134 0.1491 0.1451
Mycobacterium ulcerans beta-lactamase 0.0037 0.035 0.04
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0098 0.021
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0131 0.0022
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0019 0.0128 0.0048
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0261 0.0259
Schistosoma mansoni hypothetical protein 0.0012 0.0047 0.0037
Echinococcus multilocularis phosphoserine phosphatase 0.0019 0.0128 0.0081
Treponema pallidum cation-transporting ATPase, P-type 0.0019 0.0128 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0069 0.000000000075658
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.012 0.1329 0.132
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0102 0.1109 0.2894
Schistosoma mansoni hypothetical protein 0.0191 0.2159 0.215
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.003 0.0261 0.0259
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0019 0.0128 0.0223
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.003 0.0261 0.0598
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.1286 0.8495
Echinococcus granulosus carbonic anhydrase 0.0134 0.1491 0.1451
Onchocerca volvulus 0.003 0.0261 0.0815
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0019 0.0128 0.0048
Trypanosoma cruzi proton motive ATPase 1, putative 0.0019 0.0128 0.0111
Toxoplasma gondii propionate-CoA ligase 0.003 0.0261 0.0976
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0035 0.0326 0.2926
Trypanosoma brucei DNA polymerase eta, putative 0.0037 0.0347 0.1105
Plasmodium falciparum small ubiquitin-related modifier 0.0043 0.042 0.2139
Plasmodium falciparum acyl-CoA synthetase 0.0076 0.0806 0.4972
Loa Loa (eye worm) hypothetical protein 0.0076 0.0806 0.2371
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.035 0.0722
Onchocerca volvulus 0.003 0.0261 0.0815
Echinococcus granulosus epidermal growth factor receptor 0.0296 0.3399 0.3367
Chlamydia trachomatis pyruvate kinase 0.0037 0.0342 0.3158
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0098 0.021
Mycobacterium tuberculosis Conserved protein 0.0037 0.035 0.0722
Leishmania major pyruvate kinase 0.0037 0.0342 0.0388
Trypanosoma brucei small ubiquitin-related modifier 0.0043 0.042 0.1363
Loa Loa (eye worm) AMP-binding enzyme family protein 0.003 0.0261 0.0768
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0261 0.0467
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.003 0.0261 0.0467
Mycobacterium ulcerans cation transporter p-type ATPase D CtpD 0.0019 0.0128 0.0048
Loa Loa (eye worm) oxidoreductase 0.003 0.0261 0.0768
Schistosoma mansoni tyrosine kinase 0.0157 0.1764 0.1755
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0102 0.1109 0.2894
Treponema pallidum hypothetical protein 0.0019 0.0128 0.5
Echinococcus granulosus pyruvate kinase 0.0019 0.0131 0.0084
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0342 0.131
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.035 0.0722
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0551 0.6399 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.1109 0.3264
Brugia malayi beta-lactamase family protein 0.0037 0.035 0.103
Loa Loa (eye worm) hypothetical protein 0.0134 0.1491 0.4387
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0019 0.0128 0.0377
Leishmania major carbonic anhydrase family protein, putative 0.0551 0.6399 1
Giardia lamblia Phospholipid-transporting ATPase IA, putative 0.0019 0.0128 0.0942
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.035 0.04
Brugia malayi Ubiquitin-like protein SMT3 0.0043 0.042 0.1235
Echinococcus multilocularis cation transporting ATPase 13A1 0.0019 0.0128 0.0081
Mycobacterium ulcerans metal cation transporter ATPase p-type CtpE 0.0019 0.0128 0.0048
Trypanosoma cruzi small ubiquitin protein, putative 0.0043 0.042 0.1178
Mycobacterium tuberculosis Probable metal cation transporter ATPase P-type CtpE 0.0019 0.0128 0.0087
Echinococcus granulosus epidermal growth factor receptor 0.0159 0.1784 0.1745
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0098 0.021
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0617 0.1816
Loa Loa (eye worm) hypothetical protein 0.0134 0.1491 0.4387
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0019 0.0128 0.0081
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase CtpV 0.0019 0.0128 0.0087
Entamoeba histolytica acyl-coA synthetase, putative 0.0102 0.1109 0.1605
Trypanosoma brucei cation-transporting ATPase, putative 0.0019 0.0128 0.0319
Leishmania major acetyl-CoA synthetase, putative 0.003 0.0261 0.0259
Trypanosoma brucei acetyl-CoA synthetase, putative 0.003 0.0261 0.0795
Schistosoma mansoni tyrosine kinase 0.0095 0.1024 0.1015
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0019 0.0128 0.0223
Echinococcus multilocularis cation transporting ATPase 13A3 0.0019 0.0128 0.0081
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0019 0.0128 0.0048
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0019 0.0128 0.0111
Echinococcus granulosus ubiquitin 0.0027 0.0224 0.0178
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.003 0.0261 0.0467
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0248 0.2831 0.8329
Onchocerca volvulus 0.006 0.0617 0.2995
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0085 0.0038
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0342 0.1007
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0261 0.0259
Loa Loa (eye worm) beta-lactamase 0.0037 0.035 0.103
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0019 0.0128 0.0111
Loa Loa (eye worm) hypothetical protein 0.0037 0.035 0.103
Brugia malayi beta-lactamase family protein 0.0037 0.035 0.103
Plasmodium vivax acyl-CoA synthetase, putative 0.0076 0.0806 1
Entamoeba histolytica ubiquitin like protein 0.0043 0.042 0.0511
Trypanosoma brucei P-type H+-ATPase, putative 0.0019 0.0128 0.0319
Echinococcus multilocularis insulin receptor 0.0095 0.1024 0.0981
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0019 0.0128 0.0048
Brugia malayi Protein kinase domain containing protein 0.0095 0.1024 0.3013
Onchocerca volvulus 0.0037 0.035 0.1359
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.035 0.0304
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0098 0.021
Leishmania major P-type H -ATPase, putative 0.0019 0.0128 0.0048
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0095 0.1024 0.0981
Schistosoma mansoni pyruvate kinase 0.0037 0.0342 0.0332
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.003 0.0261 0.0598
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0102 0.1109 0.1605
Toxoplasma gondii small ubiquitin family modifier, putative 0.0043 0.042 0.2139
Echinococcus granulosus cation transporting ATPase 13A3 0.0019 0.0128 0.0081
Trypanosoma brucei carbonic anhydrase-like protein 0.0248 0.2831 1
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0019 0.0128 0.0377
Mycobacterium ulcerans carbonic anhydrase 0.0551 0.6399 1
Echinococcus multilocularis dna polymerase eta 0.0037 0.0347 0.0302
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0261 0.0467
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0019 0.0128 0.0377
Brugia malayi hypothetical protein 0.0027 0.0224 0.066
Loa Loa (eye worm) hypothetical protein 0.0076 0.0806 0.2371
Leishmania major proton motive ATPase, putative 0.0019 0.0128 0.0048
Loa Loa (eye worm) hypothetical protein 0.0076 0.0806 0.2371
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0248 0.2831 0.2823
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0218 0.0439
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.004 0.0117
Leishmania major calcium-translocating P-type ATPase 0.0019 0.0128 0.0048
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.035 0.034
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0026 0.0217 0.0652
Echinococcus multilocularis geminin 0.0191 0.2159 0.2121
Echinococcus granulosus dna polymerase eta 0.0037 0.0347 0.0302
Trichomonas vaginalis esterase, putative 0.0037 0.035 0.1062
Schistosoma mansoni pyruvate kinase 0.0037 0.0342 0.0332
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0347 0.1022
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.1491 0.4387
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0218 0.0658
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0218 0.0658
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0342 0.1007
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0342 0.3158
Mycobacterium ulcerans cation transporter p-type ATPase a CtpA 0.0019 0.0128 0.0048
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0019 0.0128 0.0081
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0076 0.0806 1
Trichomonas vaginalis antibiotic synthetase, putative 0.003 0.0261 0.0725
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0261 0.0259
Onchocerca volvulus 0.0027 0.0224 0.0588
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0238 0.2715 0.749
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0019 0.0128 0.0081
Schistosoma mansoni ATPase 0.0019 0.0128 0.0118
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0261 0.0259
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0098 0.0088
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0342 0.1031
Brugia malayi hypothetical protein 0.0017 0.0108 0.0318
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0342 0.0894
Brugia malayi CXXC zinc finger family protein 0.006 0.0617 0.1816
Echinococcus multilocularis ubiquitin 0.0027 0.0224 0.0178
Loa Loa (eye worm) hypothetical protein 0.0157 0.1761 0.5183
Schistosoma mansoni hypothetical protein 0.0134 0.1491 0.1482
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.015 0.1678 0.9488
Echinococcus granulosus carbonic anhydrase 0.0134 0.1491 0.1451
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0131 0.0045
Echinococcus granulosus cation transporting atpase worm 0.0019 0.0128 0.0081
Loa Loa (eye worm) hypothetical protein 0.0037 0.035 0.103
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.035 0.04
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.003 0.0261 0.0467
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0019 0.0128 0.0223
Trichomonas vaginalis conserved hypothetical protein 0.0238 0.2715 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0102 0.1109 0.1605
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0069 0.000000000075658
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0261 0.0259
Toxoplasma gondii ABC1 family protein 0.0037 0.035 0.1629
Loa Loa (eye worm) hypothetical protein 0.0037 0.035 0.103
Leishmania major P-type H -ATPase, putative 0.0019 0.0128 0.0048
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0098 0.0051
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0342 0.1007
Echinococcus multilocularis carbonic anhydrase 0.0134 0.1491 0.1451
Loa Loa (eye worm) acetyltransferase 0.012 0.1329 0.391
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.003 0.0261 0.0467
Loa Loa (eye worm) hypothetical protein 0.0194 0.2196 0.6463
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0019 0.0128 0.0048
Mycobacterium tuberculosis Conserved protein 0.0037 0.035 0.0722
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0019 0.0128 0.0048
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.035 0.0722
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0069 0.000000000075658
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0128 0.0081
Mycobacterium leprae conserved hypothetical protein 0.0037 0.035 0.0354
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.003 0.0261 0.0467
Loa Loa (eye worm) hypothetical protein 0.0027 0.0224 0.066
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0019 0.0128 0.0048
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.003 0.0261 0.0259
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0211 0.0621
Echinococcus multilocularis pyruvate kinase 0.0019 0.0131 0.0084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0069 0.000000000075658
Echinococcus granulosus histone acetyltransferase KAT2B 0.0035 0.0326 0.028
Schistosoma mansoni type V p-type atpase isoform 0.0019 0.0128 0.0118
Loa Loa (eye worm) AMP-binding enzyme family protein 0.003 0.0261 0.0768
Trypanosoma cruzi cation-transporting ATPase, putative 0.0019 0.0128 0.0111
Plasmodium falciparum carbonic anhydrase 0.0134 0.1491 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.003 0.0261 0.0259
Brugia malayi AMP-binding enzyme family protein 0.0102 0.1109 0.3264
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.0247 0.0727
Schistosoma mansoni tyrosine kinase 0.0095 0.1024 0.1015
Echinococcus granulosus insulin receptor 0.0095 0.1024 0.0981
Leishmania major small ubiquitin protein, putative 0.0043 0.042 0.0511
Echinococcus multilocularis phosphoserine phosphatase 0.0019 0.0128 0.0081
Loa Loa (eye worm) hypothetical protein 0.003 0.0261 0.0768
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.1412 0.1403
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0019 0.0128 0.0081
Echinococcus multilocularis dnaJ subfamily B 0.0856 1 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0102 0.1109 0.1605
Leishmania major 4-coumarate:coa ligase-like protein 0.0102 0.1109 0.1605

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.709 nM Inhibition of human carbonic anhydrase-1 ChEMBL. 23206986
Ki (binding) = 1.805 nM Inhibition of human carbonic anhydrase-2 ChEMBL. 23206986
Ki (binding) = 3.633 nM Inhibition of human carbonic anhydrase-9 ChEMBL. 23206986
Ki (binding) = 3.934 nM Inhibition of human carbonic anhydrase-12 ChEMBL. 23206986
Ki (binding) = 8.5 nM Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay ChEMBL. 23511020
Ki (binding) = 139 nM Inhibition of recombinant full length Candida albicans NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay ChEMBL. 23511020

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.