TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 357.4 | Formula: C20H23NO5
H donors: 2 H acceptors: 2 LogP: 2.55 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@@]1(C[C@@H]1c1cc(OC)c(c(c1)OC)OC)C(=O)Nc1ccccc1
InChi: 1S/C20H23NO5/c1-24-16-9-13(10-17(25-2)18(16)26-3)15-11-20(15,12-22)19(23)21-14-7-5-4-6-8-14/h4-10,15,22H,11-12H2,1-3H3,(H,21,23)/t15-,20-/m1/s1
InChiKey: QOJRMWXYWWUAQY-FOIQADDNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0294	0.0146	0.0146
Echinococcus multilocularis	neuropeptide Y receptor	0.0294	0.0146	0.0146
Schistosoma mansoni	GTPase activating protein	0.0082	0.0029	0.0029
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0454	0.0234	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0032	0.0001	0.0001
Echinococcus multilocularis	g protein coupled receptor	0.0294	0.0146	0.0146
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0034	0.0002	0.0002
Loa Loa (eye worm)	cytochrome P450 family protein	0.0329	0.0165	0.0165
Brugia malayi	Variant SH3 domain containing protein	0.0082	0.0029	0.0029
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0095	0.0036	0.1654
Schistosoma mansoni	eps8-related protein	0.0034	0.0002	0.0002
Brugia malayi	hypothetical protein	0.0294	0.0146	0.0146
Brugia malayi	Guanylate kinase family protein	0.0034	0.0002	0.0002
Echinococcus granulosus	tm gpcr rhodopsin	0.0294	0.0146	0.0146
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.0034	0.0002	0.0002
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0294	0.0146	0.0146
Schistosoma mansoni	neuropeptide receptor	0.0294	0.0146	0.0146
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0294	0.0146	0.0146
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0048	0.001	0.001
Schistosoma mansoni	hypothetical protein	0.0082	0.0029	0.0029
Loa Loa (eye worm)	acetylcholinesterase 1	0.0286	0.0141	0.0141
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0082	0.0029	0.0029
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0294	0.0146	0.0146
Echinococcus granulosus	rhodopsin orphan GPCR	0.0294	0.0146	0.0146
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0082	0.0029	0.0029
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.0002	0.0039
Entamoeba histolytica	hypothetical protein	0.0034	0.0002	0.0107
Brugia malayi	G protein-coupled receptor	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0048	0.001	0.001
Loa Loa (eye worm)	TYRA-2 protein	0.0294	0.0146	0.0146
Echinococcus multilocularis	serotonin receptor	0.0294	0.0146	0.0146
Schistosoma mansoni	vav2	0.0082	0.0029	0.0029
Brugia malayi	RE15519p	0.0294	0.0146	0.0146
Schistosoma mansoni	amine GPCR	0.0294	0.0146	0.0146
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0032	0.0001	0.0044
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.0034	0.0002	0.0002
Loa Loa (eye worm)	TK/FER protein kinase	0.0105	0.0042	0.0042
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0294	0.0146	0.0146
Echinococcus multilocularis	neuroligin	0.0048	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0029	0.0029
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0412	0.0211	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Schistosoma mansoni	opsin-like receptor	0.0294	0.0146	0.0146
Trichomonas vaginalis	spcc417.12 protein, putative	0.0048	0.001	0.0435
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0294	0.0146	0.0146
Onchocerca volvulus		0.0105	0.0042	0.169
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0294	0.0146	0.0146
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0082	0.0029	0.0029
Schistosoma mansoni	signal transduction protein lnk-related	0.0082	0.0029	0.0029
Echinococcus granulosus	mitogen activated protein kinase 14	0.1182	0.0636	0.0636
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0095	0.0036	0.0563
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0117	0.0048	0.0048
Brugia malayi	Variant SH3 domain containing protein	0.0117	0.0048	0.0048
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0105	0.0042	0.0042
Echinococcus granulosus	neuropeptide FF receptor 2	0.0294	0.0146	0.0146
Echinococcus granulosus	biogenic amine 5HT receptor	0.0294	0.0146	0.0146
Schistosoma mansoni	BC026374 protein (S09 family)	0.0048	0.001	0.001
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0294	0.0146	0.0146
Schistosoma mansoni	dreadlocks/dock	0.0034	0.0002	0.0002
Schistosoma mansoni	formin binding protein and related proteins	0.0034	0.0002	0.0002
Loa Loa (eye worm)	TK/ABL protein kinase	0.0105	0.0042	0.0042
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0105	0.0042	0.0042
Trichomonas vaginalis	neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative	0.0034	0.0002	0.0107
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0095	0.0036	0.1654
Echinococcus granulosus	SH2 motif	0.0082	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Echinococcus multilocularis	N chimaerin	0.0082	0.0029	0.0029
Brugia malayi	Src substrate cortactin	0.0034	0.0002	0.0002
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0048	0.001	0.001
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0294	0.0146	0.0146
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0294	0.0146	0.0146
Echinococcus multilocularis	g protein coupled receptor	0.0294	0.0146	0.0146
Echinococcus granulosus	rhodopsin orphan GPCR	0.0294	0.0146	0.0146
Echinococcus multilocularis	expressed protein	0.0034	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.014	0.0061	0.0061
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0095	0.0036	1
Echinococcus multilocularis	mitogen activated protein kinase 14	0.1182	0.0636	0.0636
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0095	0.0036	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0294	0.0146	0.0146
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0095	0.0036	1
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0378	0.0192	0.0192
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0294	0.0146	0.0146
Schistosoma mansoni	protein kinase	0.0032	0.0001	0.0001
Brugia malayi	Carboxylesterase family protein	0.0048	0.001	0.001
Loa Loa (eye worm)	TK/FER protein kinase	0.0105	0.0042	0.0042
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0294	0.0146	0.0146
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0095	0.0036	0.153
Schistosoma mansoni	suppressor of cytokine signaling	0.0082	0.0029	0.0029
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0095	0.0036	1
Brugia malayi	RhoGAP domain containing protein	0.0082	0.0029	0.0029
Brugia malayi	SH2 domain containing protein	0.0082	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Echinococcus granulosus	fch and double sh3 domains protein 2	0.0034	0.0002	0.0002
Schistosoma mansoni	sh3-containing grb2-like protein 1 (endophilin II)	0.0034	0.0002	0.0002
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0082	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Schistosoma mansoni	Dab2-interacting protein-like	0.0034	0.0002	0.0002
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0412	0.0211	0.0211
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0095	0.0036	0.1654
Onchocerca volvulus		0.0082	0.0029	0.114
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0294	0.0146	0.0146
Schistosoma mansoni	sorbin	0.0034	0.0002	0.0002
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0294	0.0146	0.0146
Schistosoma mansoni	hypothetical protein	0.0034	0.0002	0.0002
Schistosoma mansoni	tensin	0.0082	0.0029	0.0029
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0294	0.0146	0.0146
Onchocerca volvulus		0.0043	0.0007	0.0206
Schistosoma mansoni	adenoreceptor	0.0294	0.0146	0.0146
Schistosoma mansoni	adapter molecule crk	0.0117	0.0048	0.0048
Echinococcus granulosus	biogenic amine 5HT receptor	0.0294	0.0146	0.0146
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0412	0.0211	0.0211
Loa Loa (eye worm)	guanylate kinase	0.0034	0.0002	0.0002
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0412	0.0211	0.0211
Echinococcus granulosus	7tm_1 domain containing protein	0.0294	0.0146	0.0146
Brugia malayi	Peripheral plasma membrane protein CASK	0.0034	0.0002	0.0002
Onchocerca volvulus		0.0048	0.001	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Brugia malayi	putative neuropeptide receptor	0.0294	0.0146	0.0146
Entamoeba histolytica	hypothetical protein	0.0034	0.0002	0.0107
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0048	0.001	0.001
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0048	0.001	0.001
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0082	0.0029	0.0029
Echinococcus multilocularis	SH2 domain containing protein 7	0.0082	0.0029	0.0029
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0294	0.0146	0.0146
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0082	0.0029	0.114
Brugia malayi	follicle stimulating hormone receptor	0.0294	0.0146	0.0146
Echinococcus granulosus	tyrosine protein kinase Srms	0.0105	0.0042	0.0042
Loa Loa (eye worm)	carboxylesterase	0.0286	0.0141	0.0141
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.0034	0.0002	0.0002
Schistosoma mansoni	neuropeptide receptor	0.7877	0.4334	0.4334
Brugia malayi	SH2 domain containing protein	0.0082	0.0029	0.0029
Echinococcus multilocularis	somatostatin receptor	0.0294	0.0146	0.0146
Echinococcus multilocularis	para nitrobenzyl esterase	0.0048	0.001	0.001
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0034	0.0002	0.0002
Schistosoma mansoni	run and tbc1 domain containing	0.0034	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Echinococcus granulosus	dro:myosuppressin receptor	0.0294	0.0146	0.0146
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0378	0.0192	0.0192
Brugia malayi	hypothetical protein	0.0294	0.0146	0.0146
Schistosoma mansoni	shc transforming protein	0.0082	0.0029	0.0029
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0095	0.0036	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0294	0.0146	0.0146
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0095	0.0036	0.0563
Schistosoma mansoni	tyrosine kinase	0.0105	0.0042	0.0042
Loa Loa (eye worm)	cytochrome P450	0.0095	0.0036	0.0036
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0294	0.0146	0.0146
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0294	0.0146	0.0146
Brugia malayi	Variant SH3 domain containing protein	0.0034	0.0002	0.0002
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0095	0.0036	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0042	0.0042
Echinococcus granulosus	tyrosine protein kinase shark	0.2092	0.1139	0.1139
Echinococcus multilocularis	fmrfamide receptor	0.0294	0.0146	0.0146
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0095	0.0036	0.1654
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0412	0.0211	0.0211
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0082	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0048	0.001	0.001
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0082	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0032	0.0001	0.0016
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0412	0.0211	0.0211
Onchocerca volvulus		0.0294	0.0146	0.6186
Loa Loa (eye worm)	hypothetical protein	0.0048	0.001	0.001
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0454	0.0234	0.0234
Echinococcus granulosus	rhodopsin orphan GPCR	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	1.8139	1	1
Brugia malayi	neuropeptide F receptor	0.0294	0.0146	0.0146
Schistosoma mansoni	biogenic amine receptor	0.0294	0.0146	0.0146
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0294	0.0146	0.6186
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0412	0.0211	0.0211
Brugia malayi	G-protein coupled receptor	0.0294	0.0146	0.0146
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0454	0.0234	0.0234
Loa Loa (eye worm)	TK/FER protein kinase	0.0105	0.0042	0.0042
Schistosoma mansoni	acetylcholinesterase	0.0048	0.001	0.001
Echinococcus granulosus	tyrosine protein kinase HCK	0.0296	0.0147	0.0147
Echinococcus multilocularis	acetylcholinesterase	0.0286	0.0141	0.0141
Brugia malayi	Dopamine receptor protein 2	0.0294	0.0146	0.0146
Schistosoma mansoni	biogenic amine receptor	0.0294	0.0146	0.0146
Echinococcus granulosus	SHC transforming protein 3	0.0082	0.0029	0.0029
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0095	0.0036	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0029	0.0029
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0095	0.0036	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0082	0.0029	0.0029
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0294	0.0146	0.0146
Loa Loa (eye worm)	cytochrome P450 family protein	0.0095	0.0036	0.0036
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0082	0.0029	0.0029
Brugia malayi	Carboxylesterase family protein	0.0286	0.0141	0.0141
Plasmodium falciparum	glycogen synthase kinase 3	0.0454	0.0234	1
Onchocerca volvulus		0.0048	0.001	0.0332
Schistosoma mansoni	hypothetical protein	0.0034	0.0002	0.0002
Entamoeba histolytica	SH2 domain containing protein	0.0082	0.0029	0.1235
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Echinococcus granulosus	neuropeptide receptor	0.0294	0.0146	0.0146
Brugia malayi	Melatonin receptor type 1A	0.0294	0.0146	0.0146
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0294	0.0146	0.0146
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0002	0.0107
Loa Loa (eye worm)	TK/FER protein kinase	0.0105	0.0042	0.0042
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0294	0.0146	0.0146
Brugia malayi	SH2 domain containing protein	0.0082	0.0029	0.0029
Echinococcus granulosus	signal transduction protein lnk realted	0.0082	0.0029	0.0029
Echinococcus granulosus	rhodopsin orphan GPCR	0.0294	0.0146	0.0146
Echinococcus granulosus	neuropeptide Y receptor	0.0294	0.0146	0.0146
Onchocerca volvulus		0.0048	0.001	0.0332
Brugia malayi	Cytochrome P450 family protein	0.0095	0.0036	0.0036
Echinococcus granulosus	neuropeptide receptor A26	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Loa Loa (eye worm)	carboxylesterase	0.0048	0.001	0.001
Brugia malayi	Dopamine receptor	0.0294	0.0146	0.0146
Echinococcus granulosus	endophilin A3	0.0034	0.0002	0.0002
Brugia malayi	P38 map kinase family protein 2	0.1182	0.0636	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0048	0.001	0.001
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0095	0.0036	1
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Onchocerca volvulus		0.0294	0.0146	0.6186
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0002	0.0107
Plasmodium falciparum	protein kinase, putative	0.0032	0.0001	0.0044
Echinococcus granulosus	tensin	0.0082	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0029	0.0029
Brugia malayi	Myosin tail family protein	0.0034	0.0002	0.0002
Schistosoma mansoni	myosin xvIII	0.0294	0.0146	0.0146
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0294	0.0146	0.0146
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0286	0.0141	0.0141
Schistosoma mansoni	growth factor receptor-bound protein	0.0117	0.0048	0.0048
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0095	0.0036	0.1654
Echinococcus granulosus	N chimaerin	0.0082	0.0029	0.0029
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0082	0.0029	0.0029
Brugia malayi	Protein kinase domain containing protein	0.0105	0.0042	0.0042
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0095	0.0036	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.2092	0.1139	0.1139
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0048	0.001	0.001
Entamoeba histolytica	hypothetical protein, conserved	0.0034	0.0002	0.0107
Echinococcus multilocularis	acetylcholinesterase	0.0286	0.0141	0.0141
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0294	0.0146	0.0146
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0294	0.0146	0.0146
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0048	0.001	0.001
Loa Loa (eye worm)	G-protein coupled receptor	0.0294	0.0146	0.0146
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0095	0.0036	0.1654
Echinococcus granulosus	tm gpcr rhodopsin	0.0294	0.0146	0.0146
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0034	0.0002	0.0002
Brugia malayi	Tyrosine-protein kinase abl-1	0.014	0.0061	0.0061
Echinococcus granulosus	tyrosine kinase	0.0378	0.0192	0.0192
Entamoeba histolytica	protein kinase, putative	0.0034	0.0002	0.0107
Onchocerca volvulus		0.0294	0.0146	0.6186
Onchocerca volvulus		0.0294	0.0146	0.6186
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0034	0.0002	0.0002
Leishmania major	cytochrome p450-like protein	0.0095	0.0036	0.0563
Echinococcus multilocularis	nostrin	0.0034	0.0002	0.0002
Onchocerca volvulus		0.0105	0.0042	0.169
Schistosoma mansoni	neuropeptide receptor	0.0294	0.0146	0.0146
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0454	0.0234	0.0234
Mycobacterium leprae	putative cytochrome p450	0.0095	0.0036	0.5
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Schistosoma mansoni	SH2A	0.0082	0.0029	0.0029
Echinococcus multilocularis	neuropeptide receptor	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Loa Loa (eye worm)	SRC-1	0.0412	0.0211	0.0211
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0095	0.0036	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0412	0.0211	0.0211
Schistosoma mansoni	hypothetical protein	0.0294	0.0146	0.0146
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0095	0.0036	0.1654
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0029	0.0029
Entamoeba histolytica	hypothetical protein	0.0034	0.0002	0.0107
Onchocerca volvulus		0.0294	0.0146	0.6186
Schistosoma mansoni	amine GPCR	0.0294	0.0146	0.0146
Giardia lamblia	Kinase, CMGC GSK	0.0454	0.0234	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0294	0.0146	0.0146
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0082	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0002	0.0107
Brugia malayi	Variant SH3 domain containing protein	0.0034	0.0002	0.0002
Loa Loa (eye worm)	cytochrome P450 family protein	0.0329	0.0165	0.0165
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Echinococcus multilocularis	neuropeptide s receptor	0.0294	0.0146	0.0146
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0095	0.0036	0.1654
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Echinococcus granulosus	neuropeptide Y receptor	0.0294	0.0146	0.0146
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0095	0.0036	0.0563
Brugia malayi	putative neuropeptide receptor NPR1	0.0294	0.0146	0.0146
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0095	0.0036	0.1654
Echinococcus granulosus	acetylcholinesterase	0.0286	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0048	0.001	0.001
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0095	0.0036	0.1654
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0105	0.0042	0.0042
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0095	0.0036	1
Onchocerca volvulus		0.0294	0.0146	0.6186
Brugia malayi	Protein kinase domain containing protein	0.0105	0.0042	0.0042
Echinococcus multilocularis	tyrosine protein kinase Abl	0.014	0.0061	0.0061
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0082	0.0029	0.0029
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.0034	0.0002	0.0002
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0294	0.0146	0.0146
Echinococcus multilocularis	SH2 motif	0.0082	0.0029	0.0029
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0294	0.0146	0.0146
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0082	0.0029	0.0029
Echinococcus granulosus	cytochrome P450 2K1	0.0095	0.0036	0.0036
Schistosoma mansoni	neuropeptide receptor	0.0294	0.0146	0.0146
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0412	0.0211	0.0211
Entamoeba histolytica	unconventional myosin IB	0.0034	0.0002	0.0107
Loa Loa (eye worm)	TK/FER protein kinase	0.0105	0.0042	0.0042
Loa Loa (eye worm)	TK/FER protein kinase	0.0105	0.0042	0.0042
Schistosoma mansoni	hypothetical protein	0.0294	0.0146	0.0146
Brugia malayi	Cytochrome P450 family protein	0.0329	0.0165	0.0165
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0095	0.0036	1
Brugia malayi	hypothetical protein	0.0294	0.0146	0.0146
Brugia malayi	G-protein coupled receptor	0.0294	0.0146	0.0146
Brugia malayi	ORL1-like opioid receptor	0.0294	0.0146	0.0146
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0294	0.0146	0.0146
Onchocerca volvulus		0.0454	0.0234	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0029	0.0029
Echinococcus granulosus	tm gpcr rhodopsin	0.0294	0.0146	0.0146
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0294	0.0146	0.0146
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0294	0.0146	0.0146
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0355	0.018	0.018
Echinococcus granulosus	expressed protein	0.0034	0.0002	0.0002
Schistosoma mansoni	sorting nexin	0.0034	0.0002	0.0002
Leishmania major	hypothetical protein, conserved	0.0034	0.0002	0.0039
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0095	0.0036	1
Onchocerca volvulus		0.0294	0.0146	0.6186
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0454	0.0234	0.3679
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0412	0.0211	0.0211
Echinococcus granulosus	neuropeptide s receptor	0.0294	0.0146	0.0146
Onchocerca volvulus		0.0105	0.0042	0.169
Loa Loa (eye worm)	hypothetical protein	0.0048	0.001	0.001
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0082	0.0029	0.0029
Loa Loa (eye worm)	neuropeptide F receptor	0.0294	0.0146	0.0146
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0294	0.0146	0.0146
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0095	0.0036	0.1654
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0048	0.001	0.0435
Loa Loa (eye worm)	thyroid receptor interactor	0.0034	0.0002	0.0002
Entamoeba histolytica	protein kinase domain containing protein	0.0454	0.0234	1
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0294	0.0146	0.0146
Echinococcus granulosus	7TM GPCR rhodopsin	0.0294	0.0146	0.0146
Echinococcus granulosus	epidermal growth factor receptor kinase	0.0034	0.0002	0.0002
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.0002	0.0039
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0105	0.0042	0.1779
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0294	0.0146	0.0146
Schistosoma mansoni	protein kinase	0.0032	0.0001	0.0001
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0095	0.0036	0.1654
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0002	0.0002
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0095	0.0036	1
Brugia malayi	Variant SH3 domain containing protein	0.0034	0.0002	0.0002
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0294	0.0146	0.0146
Brugia malayi	Protein kinase domain containing protein	0.0105	0.0042	0.0042
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.0034	0.0002	0.0002
Echinococcus multilocularis	activin receptor type	0.0032	0.0001	0.0001
Loa Loa (eye worm)	TK/FER protein kinase	0.0105	0.0042	0.0042
Schistosoma mansoni	neuropeptide f receptor 76f	0.0294	0.0146	0.0146
Loa Loa (eye worm)	TK/FER protein kinase	0.0105	0.0042	0.0042
Brugia malayi	Carboxylesterase family protein	0.0286	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0002	0.0002
Echinococcus multilocularis	Spectrin alpha actinin	0.0034	0.0002	0.0002
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0294	0.0146	0.0146
Loa Loa (eye worm)	carboxylesterase	0.0048	0.001	0.001
Trypanosoma brucei	conserved protein	0.0034	0.0002	0.0039
Echinococcus multilocularis	dro:myosuppressin receptor	0.0294	0.0146	0.0146
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0294	0.0146	0.0146
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0095	0.0036	0.1654
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0294	0.0146	0.0146
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0294	0.0146	0.0146
Loa Loa (eye worm)	STAT protein	0.0082	0.0029	0.0029
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0294	0.0146	0.0146
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0082	0.0029	0.0029
Schistosoma mansoni	opsin-like receptor	0.0294	0.0146	0.0146
Onchocerca volvulus		0.0294	0.0146	0.6186
Loa Loa (eye worm)	TK/FER protein kinase	0.0105	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Schistosoma mansoni	amine GPCR	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0029	0.0029
Entamoeba histolytica	protein kinase, putative	0.0454	0.0234	1
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0095	0.0036	0.1654
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0095	0.0036	1
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0034	0.0002	0.0107
Echinococcus multilocularis	intersectin 2	0.0034	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Loa Loa (eye worm)	melatonin receptor type 1A	0.0294	0.0146	0.0146
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0454	0.0234	0.0234
Brugia malayi	Spectrin alpha chain	0.0034	0.0002	0.0002
Trichomonas vaginalis	p67phox protein, putative	0.0034	0.0002	0.0107
Echinococcus multilocularis	g protein coupled receptor	0.0294	0.0146	0.0146
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0082	0.0029	0.0029
Echinococcus multilocularis	neuropeptide receptor	0.7877	0.4334	0.4334
Echinococcus multilocularis	g-protein coupled receptor	0.0294	0.0146	0.0146
Onchocerca volvulus		0.0294	0.0146	0.6186
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.0034	0.0002	0.0002
Brugia malayi	hypothetical protein	0.0082	0.0029	0.0029
Onchocerca volvulus		0.0294	0.0146	0.6186
Entamoeba histolytica	BAR/SH3 domain containing protein	0.0034	0.0002	0.0107
Brugia malayi	Serotonin receptor	0.0294	0.0146	0.0146
Schistosoma mansoni	tensin	0.0082	0.0029	0.0029
Echinococcus granulosus	orexin receptor type 2	0.0294	0.0146	0.0146
Schistosoma mansoni	cytochrome P450	0.0095	0.0036	0.0036
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0034	0.0002	0.0002
Echinococcus granulosus	g protein coupled receptor	0.0294	0.0146	0.0146
Loa Loa (eye worm)	SH2 domain-containing protein	0.0082	0.0029	0.0029
Echinococcus granulosus	neuropeptides capa receptor	0.0294	0.0146	0.0146
Echinococcus multilocularis	NCK adaptor protein	0.0117	0.0048	0.0048
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0294	0.0146	0.0146
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0117	0.0048	0.0048
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0032	0.0001	0.0001
Brugia malayi	larval opioid receptor	0.0294	0.0146	0.0146
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0294	0.0146	0.0146
Echinococcus multilocularis	neuropeptide receptor A26	0.0294	0.0146	0.0146
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0294	0.0146	0.0146
Brugia malayi	GnHR receptor homolog	0.0294	0.0146	0.0146
Echinococcus granulosus	para nitrobenzyl esterase	0.0048	0.001	0.001
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0082	0.0029	0.0029
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.1182	0.0636	1
Schistosoma mansoni	tyrosine kinase	0.014	0.0061	0.0061
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0421	0.0216	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0029	0.0029
Brugia malayi	Carboxylesterase family protein	0.0048	0.001	0.001
Onchocerca volvulus		0.0105	0.0042	0.169
Echinococcus multilocularis	SH2 motif	0.0082	0.0029	0.0029
Echinococcus multilocularis	alpha 1,6 mannosyl glycoprotein	1.8139	1	1
Entamoeba histolytica	protein kinase, putative	0.0091	0.0034	0.1438
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0355	0.018	0.018
Echinococcus granulosus	allatostatin A receptor	0.0294	0.0146	0.0146
Loa Loa (eye worm)	TK/FER protein kinase	0.0105	0.0042	0.0042
Trypanosoma cruzi	paraflagellar rod protein 5, putative	0.0034	0.0002	0.0039
Schistosoma mansoni	opsin-like receptor	0.0294	0.0146	0.0146
Trypanosoma brucei	protein kinase, putative	0.0454	0.0234	0.3679
Echinococcus granulosus	rhodopsin orphan GPCR	0.0294	0.0146	0.0146
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0117	0.0048	0.0048
Schistosoma mansoni	growth hormone secretagogue receptor	0.0294	0.0146	0.0146
Schistosoma mansoni	histamine h1 receptor	0.0294	0.0146	0.0146
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.0034	0.0002	0.0002
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0082	0.0029	0.0029
Brugia malayi	hypothetical protein	0.0294	0.0146	0.0146
Echinococcus granulosus	g protein coupled receptor	0.0294	0.0146	0.0146
Echinococcus granulosus	protein kinase shaggy	0.0454	0.0234	0.0234
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0294	0.0146	0.0146
Echinococcus multilocularis	sex peptide receptor	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Echinococcus granulosus	SH2 motif	0.0082	0.0029	0.0029
Trypanosoma cruzi	cytochrome P450, putative	0.0329	0.0165	0.2597
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Leishmania major	cytochrome p450-like protein	0.0095	0.0036	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0002	0.0002
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0294	0.0146	0.0146
Echinococcus multilocularis	mitogen activated protein kinase 14	0.1182	0.0636	0.0636
Schistosoma mansoni	tyrosine kinase	0.2092	0.1139	0.1139
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0329	0.0165	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Schistosoma mansoni	tyrosine kinase	0.0412	0.0211	0.0211
Brugia malayi	hypothetical protein	0.0294	0.0146	0.0146
Schistosoma mansoni	cell polarity protein	0.0034	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0454	0.0234	0.3679
Brugia malayi	protein-tyrosine kinase	0.0378	0.0192	0.0192
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Onchocerca volvulus		0.0082	0.0029	0.114
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Brugia malayi	Serotonin receptor	0.0294	0.0146	0.0146
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.014	0.0061	0.0061
Schistosoma mansoni	hypothetical protein	0.0095	0.0036	0.0036
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0294	0.0146	0.0146
Echinococcus multilocularis	c src tyrosine kinase	0.014	0.0061	0.0061
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0294	0.0146	0.0146
Onchocerca volvulus		0.0048	0.001	0.0332
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0294	0.0146	0.0146
Schistosoma mansoni	apoptosis stimulating of P53	0.0034	0.0002	0.0002
Loa Loa (eye worm)	SH2 domain-containing protein	0.0082	0.0029	0.0029
Echinococcus granulosus	serotonin receptor	0.0294	0.0146	0.0146
Echinococcus granulosus	neuropeptides capa receptor	0.0294	0.0146	0.0146
Echinococcus multilocularis	protein kinase shaggy	0.0454	0.0234	0.0234
Brugia malayi	AKH receptor	0.0294	0.0146	0.0146
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.1182	0.0636	1
Echinococcus multilocularis	tensin	0.0082	0.0029	0.0029
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0095	0.0036	0.0563
Echinococcus multilocularis	endophilin A3	0.0034	0.0002	0.0002
Onchocerca volvulus		0.0294	0.0146	0.6186
Echinococcus multilocularis	SHC transforming protein 3	0.0082	0.0029	0.0029
Schistosoma mansoni	hypothetical protein	0.0294	0.0146	0.0146
Echinococcus multilocularis	mitogen activated protein kinase 11	0.1182	0.0636	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Echinococcus granulosus	carboxylesterase 5A	0.0286	0.0141	0.0141
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0294	0.0146	0.0146
Echinococcus granulosus	mitogen activated protein kinase 11	0.1182	0.0636	0.0636
Brugia malayi	G protein-coupled receptor F59B2.13	0.0294	0.0146	0.0146
Brugia malayi	SH2 domain containing protein	0.0105	0.0042	0.0042
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0294	0.0146	0.0146
Onchocerca volvulus		0.0082	0.0029	0.114
Echinococcus multilocularis	transfer RNA-Ala	0.0034	0.0002	0.0002
Brugia malayi	hypothetical protein	0.0105	0.0042	0.0042
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.0002	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0002	0.0002
Schistosoma mansoni	tyrosine kinase	0.014	0.0061	0.0061
Brugia malayi	SRC-1	0.0412	0.0211	0.0211
Loa Loa (eye worm)	p53BP2	0.0034	0.0002	0.0002
Schistosoma mansoni	beta-12-n-acetylglucosaminyltransferase II	1.8139	1	1
Echinococcus granulosus	BC026374 protein S09 family	0.0048	0.001	0.001
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0378	0.0192	0.0192
Schistosoma mansoni	tensin-related	0.0082	0.0029	0.0029
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0095	0.0036	0.1654
Onchocerca volvulus		0.0294	0.0146	0.6186
Brugia malayi	hypothetical protein	0.0294	0.0146	0.0146
Schistosoma mansoni	tyrosine kinase	0.0412	0.0211	0.0211
Echinococcus multilocularis	tyrosine kinase	0.0105	0.0042	0.0042
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0048	0.001	0.001
Schistosoma mansoni	gliotactin	0.0048	0.001	0.001
Brugia malayi	Tensin	0.0082	0.0029	0.0029
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.0034	0.0002	0.0002
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0117	0.0048	0.0048
Brugia malayi	SH2 domain containing protein	0.0105	0.0042	0.0042
Entamoeba histolytica	hypothetical protein, conserved	0.0034	0.0002	0.0107
Trichomonas vaginalis	CMGC family protein kinase	0.0454	0.0234	1
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0095	0.0036	0.1654
Schistosoma mansoni	hypothetical protein	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0029	0.0029
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0454	0.0234	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0294	0.0146	0.0146
Loa Loa (eye worm)	protein-tyrosine kinase	0.0034	0.0002	0.0002
Echinococcus multilocularis	SH2 motif	0.0082	0.0029	0.0029
Schistosoma mansoni	tensin	0.0082	0.0029	0.0029
Echinococcus multilocularis	fmrfamide receptor	0.0294	0.0146	0.0146
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0296	0.0147	0.0147
Entamoeba histolytica	protein kinase, putative	0.0296	0.0147	0.6274
Loa Loa (eye worm)	neuropeptide F receptor	0.0294	0.0146	0.0146
Onchocerca volvulus		0.0294	0.0146	0.6186
Brugia malayi	hypothetical protein	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0048	0.0048
Entamoeba histolytica	hypothetical protein	0.0034	0.0002	0.0107
Echinococcus multilocularis	carboxylesterase 5A	0.0286	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0002	0.0002
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0294	0.0146	0.0146
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0082	0.0029	0.0029
Onchocerca volvulus		0.0105	0.0042	0.169
Echinococcus granulosus	growth factor receptor bound protein 2	0.0117	0.0048	0.0048
Brugia malayi	SH2 domain containing protein	0.0082	0.0029	0.0029
Echinococcus multilocularis	neuropeptides capa receptor	0.0294	0.0146	0.0146
Brugia malayi	SH2 domain containing protein	0.0082	0.0029	0.0029
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0294	0.0146	0.0146
Echinococcus granulosus	G protein coupled receptor 139	0.0294	0.0146	0.0146
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.0015	0.0015
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0082	0.0029	0.0029
Echinococcus granulosus	intersectin 2	0.0034	0.0002	0.0002
Echinococcus multilocularis	tensin	0.0082	0.0029	0.0029
Loa Loa (eye worm)	SH2 domain-containing protein	0.0082	0.0029	0.0029
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0032	0.0001	0.0016
Echinococcus multilocularis		0.0082	0.0029	0.0029
Echinococcus granulosus	activin receptor type	0.0032	0.0001	0.0001
Echinococcus granulosus	hypothetical protein	0.0082	0.0029	0.0029
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0082	0.0029	0.114
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0095	0.0036	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0029	0.0029
Echinococcus granulosus	neuroligin	0.0048	0.001	0.001
Echinococcus granulosus	acetylcholinesterase	0.0286	0.0141	0.0141
Schistosoma mansoni	neuropeptide F-like receptor	0.0294	0.0146	0.0146
Mycobacterium leprae	Conserved hypothetical protein	0.0095	0.0036	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0412	0.0211	0.0211
Echinococcus multilocularis	mitogen activated protein kinase 11	0.1182	0.0636	0.0636
Echinococcus multilocularis	orexin receptor type 2	0.0294	0.0146	0.0146
Echinococcus multilocularis	allatostatin A receptor	0.0294	0.0146	0.0146
Echinococcus granulosus	src region	0.0034	0.0002	0.0002
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0082	0.0029	0.0029
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0294	0.0146	0.0146
Giardia lamblia	Kinase, CMGC GSK	0.0454	0.0234	1
Brugia malayi	Sex muscle abnormal protein 5	0.0117	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0286	0.0141	0.0141
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0412	0.0211	0.0211
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0082	0.0029	0.0029
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0294	0.0146	0.6186
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0412	0.0211	0.0211
Echinococcus granulosus	sex peptide receptor	0.0294	0.0146	0.0146
Onchocerca volvulus		0.0294	0.0146	0.6186
Loa Loa (eye worm)	hypothetical protein	0.0234	0.0113	0.0113
Echinococcus multilocularis		0.0095	0.0036	0.0036
Brugia malayi	Carboxylesterase family protein	0.0048	0.001	0.001
Entamoeba histolytica	hypothetical protein	0.0034	0.0002	0.0107
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0002	0.0107
Trichomonas vaginalis	CMGC family protein kinase	0.0454	0.0234	1
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0095	0.0036	0.1654
Schistosoma mansoni	dynamin-associated protein	0.0034	0.0002	0.0002
Echinococcus granulosus	SH2 domain containing protein 7	0.0082	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0002	0.0002
Echinococcus granulosus	tyrosine kinase	0.0105	0.0042	0.0042
Echinococcus multilocularis	G protein coupled receptor 139	0.7877	0.4334	0.4334
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0029	0.0029
Echinococcus granulosus	alpha 16 mannosyl glycoprotein	1.8139	1	1
Brugia malayi	hypothetical protein	0.0294	0.0146	0.0146
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0095	0.0036	0.1654
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0091	0.0034	0.1438
Brugia malayi	Variant SH3 domain containing protein	0.0034	0.0002	0.0002
Echinococcus granulosus	fmrfamide receptor	0.0294	0.0146	0.0146
Brugia malayi	cytochrome P450	0.0095	0.0036	0.0036
Brugia malayi	Protein kinase domain containing protein	0.0105	0.0042	0.0042
Loa Loa (eye worm)	TK protein kinase	0.0296	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Brugia malayi	Variant SH3 domain containing protein	0.0117	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Schistosoma mansoni	hypothetical protein	0.0082	0.0029	0.0029
Schistosoma mansoni	biogenic amine receptor	0.0294	0.0146	0.0146
Brugia malayi	Variant SH3 domain containing protein	0.0034	0.0002	0.0002
Echinococcus multilocularis	serotonin receptor	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0048	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Entamoeba histolytica	hypothetical protein	0.0034	0.0002	0.0107
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0095	0.0036	1
Entamoeba histolytica	hypothetical protein	0.0034	0.0002	0.0107
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0082	0.0029	0.0029
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0095	0.0036	0.1654
Brugia malayi	hypothetical protein	0.0294	0.0146	0.0146
Entamoeba histolytica	protein kinase domain containing protein	0.0454	0.0234	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0029	0.0029
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0412	0.0211	0.0211
Schistosoma mansoni	nck2/grb4	0.0117	0.0048	0.0048
Brugia malayi	Variant SH3 domain containing protein	0.0034	0.0002	0.0002
Brugia malayi	hypothetical protein	0.0048	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Onchocerca volvulus		0.0082	0.0029	0.114
Schistosoma mansoni	tensin-related	0.0082	0.0029	0.0029
Brugia malayi	Protein kinase domain containing protein	0.0105	0.0042	0.0042
Echinococcus granulosus	tyrosine protein kinase Blk	0.0378	0.0192	0.0192
Entamoeba histolytica	hypothetical protein	0.0034	0.0002	0.0107
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0454	0.0234	0.0234
Brugia malayi	SH3 domain containing protein	0.0034	0.0002	0.0002
Brugia malayi	neuropeptide F receptor	0.0294	0.0146	0.0146
Brugia malayi	hypothetical protein	0.0294	0.0146	0.0146
Echinococcus granulosus	expressed conserved protein	0.0082	0.0029	0.0029
Schistosoma mansoni	suppressor of cytokine signaling	0.0082	0.0029	0.0029
Echinococcus granulosus	hypothetical protein	0.0294	0.0146	0.0146
Brugia malayi	Variant SH3 domain containing protein	0.0082	0.0029	0.0029
Schistosoma mansoni	C-fyn	0.0034	0.0002	0.0002
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.1182	0.0636	1
Brugia malayi	protein-tyrosine kinase	0.0034	0.0002	0.0002
Echinococcus granulosus	nostrin	0.0034	0.0002	0.0002
Brugia malayi	Carboxylesterase family protein	0.0048	0.001	0.001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0294	0.0146	0.0146
Onchocerca volvulus		0.0294	0.0146	0.6186
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0002	0.0107
Brugia malayi	Cytochrome P450 family protein	0.0329	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.0034	0.0002	0.0002
Echinococcus granulosus	g protein coupled receptor	0.0294	0.0146	0.0146
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0002	0.0002
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0294	0.0146	0.0146
Echinococcus multilocularis	neuropeptide Y receptor	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0002	0.0002
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0002	0.0107
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0082	0.0029	0.0029
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0294	0.0146	0.0146
Brugia malayi	sulfakinin receptor protein	0.0294	0.0146	0.0146
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0002	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0029	0.0029
Echinococcus granulosus	rhodopsin orphan GPCR	0.0294	0.0146	0.0146
Entamoeba histolytica	protein kinase domain containing protein	0.0032	0.0001	0.0044
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0294	0.0146	0.0146
Onchocerca volvulus		0.0294	0.0146	0.6186
Echinococcus granulosus	somatostatin receptor	0.0294	0.0146	0.0146
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.0034	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Trypanosoma cruzi	cytochrome P450, putative	0.0329	0.0165	0.2597
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0095	0.0036	1
Schistosoma mansoni	amine GPCR	0.0294	0.0146	0.0146
Brugia malayi	Dopamine receptor protein 1	0.0294	0.0146	0.0146
Schistosoma mansoni	amine GPCR	0.0294	0.0146	0.0146
Echinococcus granulosus	g-protein coupled receptor	0.0294	0.0146	0.0146
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.014	0.0061	0.0061
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0294	0.0146	0.0146
Schistosoma mansoni	neuropeptide F-like receptor	0.0294	0.0146	0.0146
Leishmania major	protein kinase, putative	0.0032	0.0001	0.0016
Brugia malayi	intracellular kinase	0.0454	0.0234	0.0234
Leishmania major	cytochrome p450-like protein	0.0329	0.0165	0.2597
Schistosoma mansoni	protein kinase	0.0032	0.0001	0.0001
Loa Loa (eye worm)	CYP4Cod1	0.0329	0.0165	0.0165
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.1182	0.0636	0.0636
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0378	0.0192	0.0192
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0286	0.0141	0.0141
Loa Loa (eye worm)	TK protein kinase	0.0378	0.0192	0.0192
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0294	0.0146	0.0146
Schistosoma mansoni	tyrosine kinase	0.2009	0.1093	0.1093
Onchocerca volvulus		0.0294	0.0146	0.6186
Onchocerca volvulus		0.0082	0.0029	0.114
Echinococcus granulosus	NCK adaptor protein	0.0117	0.0048	0.0048
Brugia malayi	SH2 domain containing protein	0.0082	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Echinococcus granulosus	c src tyrosine kinase	0.014	0.0061	0.0061
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0105	0.0042	0.0042
Schistosoma mansoni	signal transducing adapter molecule (stam)	0.0034	0.0002	0.0002
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0294	0.0146	0.0146
Echinococcus multilocularis	signal transduction protein lnk realted	0.0082	0.0029	0.0029
Echinococcus granulosus	rhodopsin orphan GPCR	0.0294	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0412	0.0211	0.0211
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0412	0.0211	0.0211
Brugia malayi	Cytochrome P450 family protein	0.0095	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0029	0.0029
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0082	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0146	0.0146
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.1182	0.0636	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0082	0.0029	0.0029
Brugia malayi	SH2 domain containing protein	0.0082	0.0029	0.0029
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0032	0.0001	0.0016
Echinococcus granulosus	Spectrin alpha actinin	0.0034	0.0002	0.0002
Onchocerca volvulus		0.0082	0.0029	0.114
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0095	0.0036	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0082	0.0029	0.0029
Schistosoma mansoni	slit-robo rho gtpase activating protein	0.0034	0.0002	0.0002
Trypanosoma brucei	cytochrome P450, putative	0.0329	0.0165	0.2597
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0095	0.0036	1
Echinococcus granulosus	neuropeptide receptor	0.7877	0.4334	0.4334
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0294	0.0146	0.0146
Schistosoma mansoni	growth factor receptor-bound protein	0.0117	0.0048	0.0048
Onchocerca volvulus		0.0048	0.001	0.0332
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0095	0.0036	0.1654
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0034	0.0002	0.0002
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0294	0.0146	0.0146
Trypanosoma brucei	protein kinase, putative	0.0032	0.0001	0.0016
Onchocerca volvulus		0.0105	0.0042	0.169

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 100 uM	Cytotoxicity against human K562 cells after 48 hrs by MTT assay	ChEMBL.	23356786

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2316943

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1737912