Detailed information for compound 1740373

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 357.4 | Formula: C20H23NO5
  • H donors: 2 H acceptors: 2 LogP: 2.55 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@]1(C[C@H]1c1cc(OC)c(c(c1)OC)OC)C(=O)Nc1ccccc1
  • InChi: 1S/C20H23NO5/c1-24-16-9-13(10-17(25-2)18(16)26-3)15-11-20(15,12-22)19(23)21-14-7-5-4-6-8-14/h4-10,15,22H,11-12H2,1-3H3,(H,21,23)/t15-,20-/m0/s1
  • InChiKey: QOJRMWXYWWUAQY-YWZLYKJASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus allatostatin A receptor 0.0294 0.0146 0.0146
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0034 0.0002 0.0039
Loa Loa (eye worm) TK/FER protein kinase 0.0105 0.0042 0.0042
Entamoeba histolytica protein kinase, putative 0.0091 0.0034 0.1438
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0355 0.018 0.018
Echinococcus multilocularis SH2 motif 0.0082 0.0029 0.0029
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 1.8139 1 1
Onchocerca volvulus 0.0105 0.0042 0.169
Brugia malayi Carboxylesterase family protein 0.0048 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0082 0.0029 0.0029
Echinococcus granulosus tyrosine protein kinase Lyn 0.0421 0.0216 0.0216
Schistosoma mansoni tyrosine kinase 0.014 0.0061 0.0061
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0082 0.0029 0.0029
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.1182 0.0636 1
Echinococcus granulosus para nitrobenzyl esterase 0.0048 0.001 0.001
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0294 0.0146 0.0146
Echinococcus multilocularis neuropeptide receptor A26 0.0294 0.0146 0.0146
Brugia malayi GnHR receptor homolog 0.0294 0.0146 0.0146
Schistosoma mansoni alpha-1 adrenergic receptor 0.0294 0.0146 0.0146
Echinococcus multilocularis growth factor receptor bound protein 2 0.0117 0.0048 0.0048
Brugia malayi larval opioid receptor 0.0294 0.0146 0.0146
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0032 0.0001 0.0001
Echinococcus multilocularis NCK adaptor protein 0.0117 0.0048 0.0048
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0294 0.0146 0.0146
Loa Loa (eye worm) SH2 domain-containing protein 0.0082 0.0029 0.0029
Echinococcus granulosus neuropeptides capa receptor 0.0294 0.0146 0.0146
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0034 0.0002 0.0002
Echinococcus granulosus g protein coupled receptor 0.0294 0.0146 0.0146
Schistosoma mansoni cytochrome P450 0.0095 0.0036 0.0036
Echinococcus granulosus orexin receptor type 2 0.0294 0.0146 0.0146
Schistosoma mansoni tensin 0.0082 0.0029 0.0029
Brugia malayi Serotonin receptor 0.0294 0.0146 0.0146
Onchocerca volvulus 0.0294 0.0146 0.6186
Entamoeba histolytica BAR/SH3 domain containing protein 0.0034 0.0002 0.0107
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0034 0.0002 0.0002
Brugia malayi hypothetical protein 0.0082 0.0029 0.0029
Onchocerca volvulus 0.0294 0.0146 0.6186
Echinococcus multilocularis g-protein coupled receptor 0.0294 0.0146 0.0146
Echinococcus multilocularis neuropeptide receptor 0.7877 0.4334 0.4334
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0082 0.0029 0.0029
Echinococcus multilocularis g protein coupled receptor 0.0294 0.0146 0.0146
Trichomonas vaginalis p67phox protein, putative 0.0034 0.0002 0.0107
Brugia malayi Spectrin alpha chain 0.0034 0.0002 0.0002
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0454 0.0234 0.0234
Schistosoma mansoni hypothetical protein 0.0095 0.0036 0.0036
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.014 0.0061 0.0061
Brugia malayi Serotonin receptor 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Onchocerca volvulus 0.0082 0.0029 0.114
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0294 0.0146 0.0146
Brugia malayi protein-tyrosine kinase 0.0378 0.0192 0.0192
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0454 0.0234 0.3679
Brugia malayi hypothetical protein 0.0294 0.0146 0.0146
Schistosoma mansoni cell polarity protein 0.0034 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Schistosoma mansoni tyrosine kinase 0.0412 0.0211 0.0211
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Schistosoma mansoni tyrosine kinase 0.2092 0.1139 0.1139
Echinococcus multilocularis mitogen activated protein kinase 14 0.1182 0.0636 0.0636
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0329 0.0165 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0034 0.0002 0.0002
Leishmania major cytochrome p450-like protein 0.0095 0.0036 0.0563
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0082 0.0029 0.0029
Trypanosoma cruzi cytochrome P450, putative 0.0329 0.0165 0.2597
Echinococcus multilocularis sex peptide receptor 0.0294 0.0146 0.0146
Echinococcus granulosus SH2 motif 0.0082 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Echinococcus multilocularis neuropeptide FF receptor 2 0.0294 0.0146 0.0146
Echinococcus granulosus g protein coupled receptor 0.0294 0.0146 0.0146
Echinococcus granulosus protein kinase shaggy 0.0454 0.0234 0.0234
Brugia malayi hypothetical protein 0.0294 0.0146 0.0146
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0082 0.0029 0.0029
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0034 0.0002 0.0002
Schistosoma mansoni histamine h1 receptor 0.0294 0.0146 0.0146
Schistosoma mansoni growth hormone secretagogue receptor 0.0294 0.0146 0.0146
Echinococcus granulosus rhodopsin orphan GPCR 0.0294 0.0146 0.0146
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0117 0.0048 0.0048
Schistosoma mansoni opsin-like receptor 0.0294 0.0146 0.0146
Trypanosoma brucei protein kinase, putative 0.0454 0.0234 0.3679
Brugia malayi hypothetical protein 0.0294 0.0146 0.0146
Onchocerca volvulus 0.0294 0.0146 0.6186
Schistosoma mansoni tensin-related 0.0082 0.0029 0.0029
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0095 0.0036 0.1654
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0378 0.0192 0.0192
Echinococcus granulosus BC026374 protein S09 family 0.0048 0.001 0.001
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 1.8139 1 1
Loa Loa (eye worm) p53BP2 0.0034 0.0002 0.0002
Schistosoma mansoni tyrosine kinase 0.014 0.0061 0.0061
Brugia malayi SRC-1 0.0412 0.0211 0.0211
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0002 0.0039
Loa Loa (eye worm) hypothetical protein 0.0034 0.0002 0.0002
Brugia malayi hypothetical protein 0.0105 0.0042 0.0042
Onchocerca volvulus 0.0082 0.0029 0.114
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0294 0.0146 0.0146
Echinococcus multilocularis transfer RNA-Ala 0.0034 0.0002 0.0002
Brugia malayi SH2 domain containing protein 0.0105 0.0042 0.0042
Echinococcus granulosus mitogen activated protein kinase 11 0.1182 0.0636 0.0636
Brugia malayi G protein-coupled receptor F59B2.13 0.0294 0.0146 0.0146
Echinococcus granulosus carboxylesterase 5A 0.0286 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0294 0.0146 0.0146
Schistosoma mansoni hypothetical protein 0.0294 0.0146 0.0146
Echinococcus multilocularis mitogen activated protein kinase 11 0.1182 0.0636 0.0636
Echinococcus multilocularis SHC transforming protein 3 0.0082 0.0029 0.0029
Onchocerca volvulus 0.0294 0.0146 0.6186
Echinococcus multilocularis endophilin A3 0.0034 0.0002 0.0002
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0095 0.0036 0.0563
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.1182 0.0636 1
Echinococcus multilocularis tensin 0.0082 0.0029 0.0029
Echinococcus multilocularis protein kinase shaggy 0.0454 0.0234 0.0234
Brugia malayi AKH receptor 0.0294 0.0146 0.0146
Echinococcus granulosus neuropeptides capa receptor 0.0294 0.0146 0.0146
Echinococcus granulosus serotonin receptor 0.0294 0.0146 0.0146
Loa Loa (eye worm) SH2 domain-containing protein 0.0082 0.0029 0.0029
Schistosoma mansoni apoptosis stimulating of P53 0.0034 0.0002 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0294 0.0146 0.0146
Onchocerca volvulus 0.0048 0.001 0.0332
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0294 0.0146 0.0146
Echinococcus multilocularis c src tyrosine kinase 0.014 0.0061 0.0061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0294 0.0146 0.0146
Echinococcus granulosus hypothetical protein 0.0082 0.0029 0.0029
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0032 0.0001 0.0016
Echinococcus multilocularis 0.0082 0.0029 0.0029
Echinococcus granulosus activin receptor type 0.0032 0.0001 0.0001
Echinococcus multilocularis tensin 0.0082 0.0029 0.0029
Loa Loa (eye worm) SH2 domain-containing protein 0.0082 0.0029 0.0029
Brugia malayi tRNA modification GTPase TrmE family protein 0.0082 0.0029 0.0029
Echinococcus granulosus intersectin 2 0.0034 0.0002 0.0002
Echinococcus granulosus G protein coupled receptor 139 0.0294 0.0146 0.0146
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0015 0.0015
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0294 0.0146 0.0146
Brugia malayi SH2 domain containing protein 0.0082 0.0029 0.0029
Brugia malayi SH2 domain containing protein 0.0082 0.0029 0.0029
Echinococcus multilocularis neuropeptides capa receptor 0.0294 0.0146 0.0146
Echinococcus granulosus growth factor receptor bound protein 2 0.0117 0.0048 0.0048
Onchocerca volvulus 0.0105 0.0042 0.169
Echinococcus granulosus SH2 domain containing adapter protein F 0.0082 0.0029 0.0029
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0294 0.0146 0.0146
Echinococcus multilocularis carboxylesterase 5A 0.0286 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0034 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0117 0.0048 0.0048
Entamoeba histolytica hypothetical protein 0.0034 0.0002 0.0107
Brugia malayi hypothetical protein 0.0294 0.0146 0.0146
Onchocerca volvulus 0.0294 0.0146 0.6186
Loa Loa (eye worm) neuropeptide F receptor 0.0294 0.0146 0.0146
Entamoeba histolytica protein kinase, putative 0.0296 0.0147 0.6274
Echinococcus multilocularis tyrosine protein kinase HCK 0.0296 0.0147 0.0147
Echinococcus multilocularis fmrfamide receptor 0.0294 0.0146 0.0146
Schistosoma mansoni tensin 0.0082 0.0029 0.0029
Loa Loa (eye worm) protein-tyrosine kinase 0.0034 0.0002 0.0002
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0294 0.0146 0.0146
Echinococcus multilocularis SH2 motif 0.0082 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0082 0.0029 0.0029
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0454 0.0234 1
Trichomonas vaginalis CMGC family protein kinase 0.0454 0.0234 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0095 0.0036 0.1654
Entamoeba histolytica hypothetical protein, conserved 0.0034 0.0002 0.0107
Brugia malayi SH2 domain containing protein 0.0105 0.0042 0.0042
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0034 0.0002 0.0002
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0117 0.0048 0.0048
Schistosoma mansoni gliotactin 0.0048 0.001 0.001
Brugia malayi Tensin 0.0082 0.0029 0.0029
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0048 0.001 0.001
Echinococcus multilocularis tyrosine kinase 0.0105 0.0042 0.0042
Schistosoma mansoni tyrosine kinase 0.0412 0.0211 0.0211
Echinococcus granulosus fmrfamide receptor 0.0294 0.0146 0.0146
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0002 0.0002
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0091 0.0034 0.1438
Brugia malayi hypothetical protein 0.0294 0.0146 0.0146
Echinococcus granulosus alpha 16 mannosyl glycoprotein 1.8139 1 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0095 0.0036 0.1654
Loa Loa (eye worm) hypothetical protein 0.0082 0.0029 0.0029
Echinococcus multilocularis G protein coupled receptor 139 0.7877 0.4334 0.4334
Loa Loa (eye worm) hypothetical protein 0.0034 0.0002 0.0002
Echinococcus granulosus tyrosine kinase 0.0105 0.0042 0.0042
Schistosoma mansoni dynamin-associated protein 0.0034 0.0002 0.0002
Echinococcus granulosus SH2 domain containing protein 7 0.0082 0.0029 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0002 0.0107
Trichomonas vaginalis CMGC family protein kinase 0.0454 0.0234 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0095 0.0036 0.1654
Entamoeba histolytica hypothetical protein 0.0034 0.0002 0.0107
Echinococcus multilocularis 0.0095 0.0036 0.0036
Brugia malayi Carboxylesterase family protein 0.0048 0.001 0.001
Onchocerca volvulus 0.0294 0.0146 0.6186
Echinococcus granulosus sex peptide receptor 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0234 0.0113 0.0113
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0412 0.0211 0.0211
Onchocerca volvulus Neuropeptide F receptor homolog 0.0294 0.0146 0.6186
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Echinococcus granulosus tyrosine protein kinase Fyn 0.0412 0.0211 0.0211
Echinococcus granulosus suppressor of cytokine signaling 7 0.0082 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0286 0.0141 0.0141
Brugia malayi Sex muscle abnormal protein 5 0.0117 0.0048 0.0048
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0294 0.0146 0.0146
Giardia lamblia Kinase, CMGC GSK 0.0454 0.0234 1
Echinococcus granulosus src region 0.0034 0.0002 0.0002
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0082 0.0029 0.0029
Echinococcus multilocularis mitogen activated protein kinase 11 0.1182 0.0636 0.0636
Echinococcus multilocularis orexin receptor type 2 0.0294 0.0146 0.0146
Echinococcus multilocularis allatostatin A receptor 0.0294 0.0146 0.0146
Mycobacterium leprae Conserved hypothetical protein 0.0095 0.0036 0.5
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0412 0.0211 0.0211
Schistosoma mansoni neuropeptide F-like receptor 0.0294 0.0146 0.0146
Echinococcus granulosus neuroligin 0.0048 0.001 0.001
Echinococcus granulosus acetylcholinesterase 0.0286 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0082 0.0029 0.0029
Echinococcus multilocularis neuropeptides capa receptor 0.0294 0.0146 0.0146
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0082 0.0029 0.114
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0095 0.0036 1
Echinococcus granulosus nostrin 0.0034 0.0002 0.0002
Brugia malayi protein-tyrosine kinase 0.0034 0.0002 0.0002
Schistosoma mansoni C-fyn 0.0034 0.0002 0.0002
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1182 0.0636 1
Brugia malayi Variant SH3 domain containing protein 0.0082 0.0029 0.0029
Echinococcus granulosus expressed conserved protein 0.0082 0.0029 0.0029
Echinococcus granulosus hypothetical protein 0.0294 0.0146 0.0146
Schistosoma mansoni suppressor of cytokine signaling 0.0082 0.0029 0.0029
Brugia malayi hypothetical protein 0.0294 0.0146 0.0146
Brugia malayi SH3 domain containing protein 0.0034 0.0002 0.0002
Brugia malayi neuropeptide F receptor 0.0294 0.0146 0.0146
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0454 0.0234 0.0234
Echinococcus granulosus tyrosine protein kinase Blk 0.0378 0.0192 0.0192
Entamoeba histolytica hypothetical protein 0.0034 0.0002 0.0107
Brugia malayi Protein kinase domain containing protein 0.0105 0.0042 0.0042
Schistosoma mansoni tensin-related 0.0082 0.0029 0.0029
Brugia malayi hypothetical protein 0.0048 0.001 0.001
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Onchocerca volvulus 0.0082 0.0029 0.114
Schistosoma mansoni nck2/grb4 0.0117 0.0048 0.0048
Echinococcus granulosus tyrosine protein kinase Src64B 0.0412 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0082 0.0029 0.0029
Entamoeba histolytica protein kinase domain containing protein 0.0454 0.0234 1
Brugia malayi hypothetical protein 0.0294 0.0146 0.0146
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0082 0.0029 0.0029
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0095 0.0036 0.1654
Entamoeba histolytica hypothetical protein 0.0034 0.0002 0.0107
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0095 0.0036 1
Entamoeba histolytica hypothetical protein 0.0034 0.0002 0.0107
Loa Loa (eye worm) hypothetical protein 0.0048 0.001 0.001
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Echinococcus multilocularis serotonin receptor 0.0294 0.0146 0.0146
Schistosoma mansoni hypothetical protein 0.0082 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Schistosoma mansoni biogenic amine receptor 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Brugia malayi Variant SH3 domain containing protein 0.0117 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Loa Loa (eye worm) TK protein kinase 0.0296 0.0147 0.0147
Brugia malayi cytochrome P450 0.0095 0.0036 0.0036
Brugia malayi Protein kinase domain containing protein 0.0105 0.0042 0.0042
Schistosoma mansoni tyrosine kinase 0.2009 0.1093 0.1093
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0294 0.0146 0.0146
Onchocerca volvulus 0.0294 0.0146 0.6186
Loa Loa (eye worm) TK protein kinase 0.0378 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0286 0.0141 0.0141
Schistosoma mansoni biogenic amine (5HT) receptor 0.0294 0.0146 0.0146
Echinococcus multilocularis tyrosine protein kinase Blk 0.0378 0.0192 0.0192
Loa Loa (eye worm) CYP4Cod1 0.0329 0.0165 0.0165
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.1182 0.0636 0.0636
Schistosoma mansoni protein kinase 0.0032 0.0001 0.0001
Leishmania major protein kinase, putative 0.0032 0.0001 0.0016
Leishmania major cytochrome p450-like protein 0.0329 0.0165 0.2597
Brugia malayi intracellular kinase 0.0454 0.0234 0.0234
Echinococcus granulosus peptide allatostatin:somatostatin 0.0294 0.0146 0.0146
Echinococcus granulosus tyrosine protein kinase Btk29A 0.014 0.0061 0.0061
Schistosoma mansoni neuropeptide F-like receptor 0.0294 0.0146 0.0146
Echinococcus granulosus g-protein coupled receptor 0.0294 0.0146 0.0146
Schistosoma mansoni amine GPCR 0.0294 0.0146 0.0146
Schistosoma mansoni amine GPCR 0.0294 0.0146 0.0146
Brugia malayi Dopamine receptor protein 1 0.0294 0.0146 0.0146
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0095 0.0036 1
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0034 0.0002 0.0002
Trypanosoma cruzi cytochrome P450, putative 0.0329 0.0165 0.2597
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Onchocerca volvulus 0.0294 0.0146 0.6186
Echinococcus granulosus somatostatin receptor 0.0294 0.0146 0.0146
Echinococcus granulosus rhodopsin orphan GPCR 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0082 0.0029 0.0029
Entamoeba histolytica protein kinase domain containing protein 0.0032 0.0001 0.0044
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0294 0.0146 0.0146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0294 0.0146 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0002 0.0107
Brugia malayi sulfakinin receptor protein 0.0294 0.0146 0.0146
Brugia malayi STAT protein, DNA binding domain containing protein 0.0082 0.0029 0.0029
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0294 0.0146 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0002 0.0107
Loa Loa (eye worm) hypothetical protein 0.0034 0.0002 0.0002
Echinococcus multilocularis neuropeptide Y receptor 0.0294 0.0146 0.0146
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0294 0.0146 0.0146
Echinococcus granulosus g protein coupled receptor 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0034 0.0002 0.0002
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0034 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Brugia malayi Cytochrome P450 family protein 0.0329 0.0165 0.0165
Echinococcus multilocularis rhodopsin orphan GPCR 0.0294 0.0146 0.0146
Brugia malayi Carboxylesterase family protein 0.0048 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0002 0.0107
Onchocerca volvulus 0.0294 0.0146 0.6186
Trypanosoma brucei protein kinase, putative 0.0032 0.0001 0.0016
Onchocerca volvulus 0.0105 0.0042 0.169
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0294 0.0146 0.0146
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0034 0.0002 0.0002
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0095 0.0036 0.1654
Schistosoma mansoni growth factor receptor-bound protein 0.0117 0.0048 0.0048
Onchocerca volvulus 0.0048 0.001 0.0332
Echinococcus multilocularis rhodopsin orphan GPCR 0.0294 0.0146 0.0146
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0095 0.0036 1
Trypanosoma brucei cytochrome P450, putative 0.0329 0.0165 0.2597
Echinococcus granulosus neuropeptide receptor 0.7877 0.4334 0.4334
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0034 0.0002 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0095 0.0036 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0082 0.0029 0.0029
Onchocerca volvulus 0.0082 0.0029 0.114
Echinococcus granulosus Spectrin alpha actinin 0.0034 0.0002 0.0002
Brugia malayi SH2 domain containing protein 0.0082 0.0029 0.0029
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0032 0.0001 0.0016
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0082 0.0029 0.0029
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1182 0.0636 1
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0034 0.0002 0.0002
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0082 0.0029 0.0029
Brugia malayi Cytochrome P450 family protein 0.0095 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0082 0.0029 0.0029
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0412 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0412 0.0211 0.0211
Echinococcus granulosus rhodopsin orphan GPCR 0.0294 0.0146 0.0146
Echinococcus multilocularis signal transduction protein lnk realted 0.0082 0.0029 0.0029
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0294 0.0146 0.0146
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0105 0.0042 0.0042
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0034 0.0002 0.0002
Echinococcus granulosus c src tyrosine kinase 0.014 0.0061 0.0061
Brugia malayi SH2 domain containing protein 0.0082 0.0029 0.0029
Echinococcus granulosus NCK adaptor protein 0.0117 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Onchocerca volvulus 0.0082 0.0029 0.114
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Onchocerca volvulus 0.0105 0.0042 0.169
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0294 0.0146 0.0146
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0294 0.0146 0.0146
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0082 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Schistosoma mansoni opsin-like receptor 0.0294 0.0146 0.0146
Trichomonas vaginalis spcc417.12 protein, putative 0.0048 0.001 0.0435
Echinococcus granulosus tyrosine protein kinase Src42A 0.0412 0.0211 0.0211
Echinococcus multilocularis neuroligin 0.0048 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0082 0.0029 0.0029
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0294 0.0146 0.0146
Loa Loa (eye worm) TK/FER protein kinase 0.0105 0.0042 0.0042
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0032 0.0001 0.0044
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0034 0.0002 0.0002
Schistosoma mansoni vav2 0.0082 0.0029 0.0029
Schistosoma mansoni amine GPCR 0.0294 0.0146 0.0146
Brugia malayi RE15519p 0.0294 0.0146 0.0146
Echinococcus multilocularis serotonin receptor 0.0294 0.0146 0.0146
Loa Loa (eye worm) TYRA-2 protein 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0048 0.001 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0002 0.0039
Echinococcus granulosus rhodopsin orphan GPCR 0.0294 0.0146 0.0146
Entamoeba histolytica hypothetical protein 0.0034 0.0002 0.0107
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0082 0.0029 0.0029
Brugia malayi G protein-coupled receptor 0.0294 0.0146 0.0146
Brugia malayi Tachykinin-like peptides receptor 99D 0.0294 0.0146 0.0146
Loa Loa (eye worm) acetylcholinesterase 1 0.0286 0.0141 0.0141
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0082 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0082 0.0029 0.0029
Schistosoma mansoni neuroligin 3 (S09 family) 0.0048 0.001 0.001
Schistosoma mansoni neuropeptide receptor 0.0294 0.0146 0.0146
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0294 0.0146 0.0146
Echinococcus granulosus tm gpcr rhodopsin 0.0294 0.0146 0.0146
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0034 0.0002 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0294 0.0146 0.0146
Brugia malayi Guanylate kinase family protein 0.0034 0.0002 0.0002
Schistosoma mansoni eps8-related protein 0.0034 0.0002 0.0002
Brugia malayi hypothetical protein 0.0294 0.0146 0.0146
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0095 0.0036 0.1654
Echinococcus multilocularis g protein coupled receptor 0.0294 0.0146 0.0146
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0034 0.0002 0.0002
Loa Loa (eye worm) cytochrome P450 family protein 0.0329 0.0165 0.0165
Brugia malayi Variant SH3 domain containing protein 0.0082 0.0029 0.0029
Plasmodium vivax glycogen synthase kinase 3, putative 0.0454 0.0234 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0032 0.0001 0.0001
Schistosoma mansoni GTPase activating protein 0.0082 0.0029 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0294 0.0146 0.0146
Echinococcus multilocularis neuropeptide Y receptor 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Brugia malayi SH2 domain containing protein 0.0082 0.0029 0.0029
Brugia malayi RhoGAP domain containing protein 0.0082 0.0029 0.0029
Schistosoma mansoni suppressor of cytokine signaling 0.0082 0.0029 0.0029
Toxoplasma gondii cytochrome p450 superfamily protein 0.0095 0.0036 0.153
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0294 0.0146 0.0146
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0095 0.0036 1
Brugia malayi Carboxylesterase family protein 0.0048 0.001 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0105 0.0042 0.0042
Schistosoma mansoni protein kinase 0.0032 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Echinococcus multilocularis tyrosine protein kinase Srms 0.0378 0.0192 0.0192
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0095 0.0036 1
Loa Loa (eye worm) G-protein coupled receptor 0.0294 0.0146 0.0146
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0095 0.0036 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.014 0.0061 0.0061
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0095 0.0036 1
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Echinococcus multilocularis mitogen activated protein kinase 14 0.1182 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Echinococcus multilocularis expressed protein 0.0034 0.0002 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0294 0.0146 0.0146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0294 0.0146 0.0146
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0294 0.0146 0.0146
Echinococcus multilocularis g protein coupled receptor 0.0294 0.0146 0.0146
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0048 0.001 0.001
Brugia malayi Src substrate cortactin 0.0034 0.0002 0.0002
Echinococcus multilocularis N chimaerin 0.0082 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Echinococcus granulosus SH2 motif 0.0082 0.0029 0.0029
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0095 0.0036 0.1654
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0034 0.0002 0.0107
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0105 0.0042 0.0042
Schistosoma mansoni formin binding protein and related proteins 0.0034 0.0002 0.0002
Loa Loa (eye worm) TK/ABL protein kinase 0.0105 0.0042 0.0042
Schistosoma mansoni dreadlocks/dock 0.0034 0.0002 0.0002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0294 0.0146 0.0146
Schistosoma mansoni BC026374 protein (S09 family) 0.0048 0.001 0.001
Echinococcus granulosus biogenic amine 5HT receptor 0.0294 0.0146 0.0146
Echinococcus granulosus neuropeptide FF receptor 2 0.0294 0.0146 0.0146
Echinococcus granulosus tyrosine protein kinase ABL1 0.0105 0.0042 0.0042
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0117 0.0048 0.0048
Brugia malayi Variant SH3 domain containing protein 0.0117 0.0048 0.0048
Echinococcus granulosus mitogen activated protein kinase 14 0.1182 0.0636 0.0636
Schistosoma mansoni signal transduction protein lnk-related 0.0082 0.0029 0.0029
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0095 0.0036 0.0563
Schistosoma mansoni shc transforming protein 0.0082 0.0029 0.0029
Brugia malayi hypothetical protein 0.0294 0.0146 0.0146
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0378 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Echinococcus granulosus dro:myosuppressin receptor 0.0294 0.0146 0.0146
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0034 0.0002 0.0002
Schistosoma mansoni run and tbc1 domain containing 0.0034 0.0002 0.0002
Echinococcus multilocularis para nitrobenzyl esterase 0.0048 0.001 0.001
Brugia malayi SH2 domain containing protein 0.0082 0.0029 0.0029
Echinococcus multilocularis somatostatin receptor 0.0294 0.0146 0.0146
Schistosoma mansoni neuropeptide receptor 0.7877 0.4334 0.4334
Loa Loa (eye worm) carboxylesterase 0.0286 0.0141 0.0141
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0034 0.0002 0.0002
Echinococcus granulosus tyrosine protein kinase Srms 0.0105 0.0042 0.0042
Echinococcus multilocularis SH2 domain containing protein 7 0.0082 0.0029 0.0029
Brugia malayi follicle stimulating hormone receptor 0.0294 0.0146 0.0146
Echinococcus granulosus tachykinin peptides receptor 99D 0.0294 0.0146 0.0146
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0082 0.0029 0.114
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0082 0.0029 0.0029
Entamoeba histolytica hypothetical protein 0.0034 0.0002 0.0107
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0048 0.001 0.001
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0048 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Brugia malayi putative neuropeptide receptor 0.0294 0.0146 0.0146
Brugia malayi Peripheral plasma membrane protein CASK 0.0034 0.0002 0.0002
Onchocerca volvulus 0.0048 0.001 0.0332
Echinococcus granulosus 7tm_1 domain containing protein 0.0294 0.0146 0.0146
Echinococcus granulosus biogenic amine 5HT receptor 0.0294 0.0146 0.0146
Loa Loa (eye worm) guanylate kinase 0.0034 0.0002 0.0002
Echinococcus granulosus tyrosine protein kinase Fyn 0.0412 0.0211 0.0211
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0412 0.0211 0.0211
Schistosoma mansoni adapter molecule crk 0.0117 0.0048 0.0048
Schistosoma mansoni adenoreceptor 0.0294 0.0146 0.0146
Onchocerca volvulus 0.0043 0.0007 0.0206
Schistosoma mansoni tensin 0.0082 0.0029 0.0029
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0294 0.0146 0.0146
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0294 0.0146 0.0146
Schistosoma mansoni hypothetical protein 0.0034 0.0002 0.0002
Schistosoma mansoni sorbin 0.0034 0.0002 0.0002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0294 0.0146 0.0146
Onchocerca volvulus 0.0082 0.0029 0.114
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0095 0.0036 0.1654
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0412 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Schistosoma mansoni Dab2-interacting protein-like 0.0034 0.0002 0.0002
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0034 0.0002 0.0002
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0082 0.0029 0.0029
Echinococcus granulosus fch and double sh3 domains protein 2 0.0034 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0082 0.0029 0.0029
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0082 0.0029 0.0029
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0294 0.0146 0.0146
Loa Loa (eye worm) cytochrome P450 family protein 0.0095 0.0036 0.0036
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0082 0.0029 0.0029
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0095 0.0036 0.0563
Loa Loa (eye worm) hypothetical protein 0.0082 0.0029 0.0029
Echinococcus granulosus SHC transforming protein 3 0.0082 0.0029 0.0029
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0095 0.0036 1
Schistosoma mansoni biogenic amine receptor 0.0294 0.0146 0.0146
Echinococcus multilocularis acetylcholinesterase 0.0286 0.0141 0.0141
Brugia malayi Dopamine receptor protein 2 0.0294 0.0146 0.0146
Echinococcus granulosus tyrosine protein kinase HCK 0.0296 0.0147 0.0147
Loa Loa (eye worm) TK/FER protein kinase 0.0105 0.0042 0.0042
Schistosoma mansoni acetylcholinesterase 0.0048 0.001 0.001
Echinococcus granulosus tyrosine protein kinase Fyn 0.0412 0.0211 0.0211
Brugia malayi G-protein coupled receptor 0.0294 0.0146 0.0146
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0454 0.0234 0.0234
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0294 0.0146 0.6186
Schistosoma mansoni biogenic amine receptor 0.0294 0.0146 0.0146
Brugia malayi neuropeptide F receptor 0.0294 0.0146 0.0146
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0454 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 1.8139 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0294 0.0146 0.0146
Onchocerca volvulus 0.0294 0.0146 0.6186
Loa Loa (eye worm) hypothetical protein 0.0048 0.001 0.001
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0412 0.0211 0.0211
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0032 0.0001 0.0016
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0082 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0048 0.001 0.001
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0082 0.0029 0.0029
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0412 0.0211 0.0211
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0095 0.0036 0.1654
Echinococcus multilocularis fmrfamide receptor 0.0294 0.0146 0.0146
Echinococcus granulosus tyrosine protein kinase shark 0.2092 0.1139 0.1139
Loa Loa (eye worm) hypothetical protein 0.0105 0.0042 0.0042
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0095 0.0036 1
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0002 0.0002
Echinococcus granulosus alpha 1A adrenergic receptor 0.0294 0.0146 0.0146
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0294 0.0146 0.0146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0294 0.0146 0.0146
Loa Loa (eye worm) cytochrome P450 0.0095 0.0036 0.0036
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0095 0.0036 0.0563
Schistosoma mansoni tyrosine kinase 0.0105 0.0042 0.0042
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0095 0.0036 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0048 0.001 0.001
Echinococcus multilocularis tyrosine protein kinase shark 0.2092 0.1139 0.1139
Entamoeba histolytica hypothetical protein, conserved 0.0034 0.0002 0.0107
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0294 0.0146 0.0146
Echinococcus multilocularis acetylcholinesterase 0.0286 0.0141 0.0141
Schistosoma mansoni biogenic amine (5HT) receptor 0.0294 0.0146 0.0146
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0095 0.0036 1
Brugia malayi Protein kinase domain containing protein 0.0105 0.0042 0.0042
Brugia malayi cytokine inducible SH2-containing protein 5 0.0082 0.0029 0.0029
Echinococcus granulosus N chimaerin 0.0082 0.0029 0.0029
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0095 0.0036 0.1654
Schistosoma mansoni myosin xvIII 0.0294 0.0146 0.0146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0294 0.0146 0.0146
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0286 0.0141 0.0141
Schistosoma mansoni growth factor receptor-bound protein 0.0117 0.0048 0.0048
Brugia malayi Myosin tail family protein 0.0034 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0082 0.0029 0.0029
Echinococcus granulosus tensin 0.0082 0.0029 0.0029
Plasmodium falciparum protein kinase, putative 0.0032 0.0001 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0002 0.0107
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Onchocerca volvulus 0.0294 0.0146 0.6186
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0095 0.0036 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.001 0.001
Brugia malayi P38 map kinase family protein 2 0.1182 0.0636 0.0636
Echinococcus granulosus endophilin A3 0.0034 0.0002 0.0002
Brugia malayi Dopamine receptor 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Loa Loa (eye worm) carboxylesterase 0.0048 0.001 0.001
Brugia malayi Cytochrome P450 family protein 0.0095 0.0036 0.0036
Echinococcus granulosus neuropeptide receptor A26 0.0294 0.0146 0.0146
Echinococcus granulosus rhodopsin orphan GPCR 0.0294 0.0146 0.0146
Echinococcus granulosus neuropeptide Y receptor 0.0294 0.0146 0.0146
Onchocerca volvulus 0.0048 0.001 0.0332
Brugia malayi SH2 domain containing protein 0.0082 0.0029 0.0029
Echinococcus granulosus signal transduction protein lnk realted 0.0082 0.0029 0.0029
Loa Loa (eye worm) TK/FER protein kinase 0.0105 0.0042 0.0042
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0294 0.0146 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0002 0.0107
Brugia malayi Melatonin receptor type 1A 0.0294 0.0146 0.0146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Echinococcus granulosus neuropeptide receptor 0.0294 0.0146 0.0146
Schistosoma mansoni hypothetical protein 0.0034 0.0002 0.0002
Onchocerca volvulus 0.0048 0.001 0.0332
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0294 0.0146 0.0146
Entamoeba histolytica SH2 domain containing protein 0.0082 0.0029 0.1235
Brugia malayi Carboxylesterase family protein 0.0286 0.0141 0.0141
Plasmodium falciparum glycogen synthase kinase 3 0.0454 0.0234 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0329 0.0165 0.0165
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0002 0.0107
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0082 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0294 0.0146 0.0146
Giardia lamblia Kinase, CMGC GSK 0.0454 0.0234 1
Schistosoma mansoni amine GPCR 0.0294 0.0146 0.0146
Onchocerca volvulus 0.0294 0.0146 0.6186
Entamoeba histolytica hypothetical protein 0.0034 0.0002 0.0107
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0095 0.0036 0.1654
Loa Loa (eye worm) hypothetical protein 0.0082 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0294 0.0146 0.0146
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0095 0.0036 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0412 0.0211 0.0211
Loa Loa (eye worm) SRC-1 0.0412 0.0211 0.0211
Echinococcus multilocularis neuropeptide receptor 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Schistosoma mansoni SH2A 0.0082 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0454 0.0234 0.0234
Mycobacterium leprae putative cytochrome p450 0.0095 0.0036 0.5
Schistosoma mansoni neuropeptide receptor 0.0294 0.0146 0.0146
Onchocerca volvulus 0.0105 0.0042 0.169
Leishmania major cytochrome p450-like protein 0.0095 0.0036 0.0563
Echinococcus multilocularis nostrin 0.0034 0.0002 0.0002
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0034 0.0002 0.0002
Onchocerca volvulus 0.0294 0.0146 0.6186
Entamoeba histolytica protein kinase, putative 0.0034 0.0002 0.0107
Onchocerca volvulus 0.0294 0.0146 0.6186
Echinococcus granulosus tm gpcr rhodopsin 0.0294 0.0146 0.0146
Brugia malayi Tyrosine-protein kinase abl-1 0.014 0.0061 0.0061
Echinococcus granulosus tyrosine kinase 0.0378 0.0192 0.0192
Brugia malayi Fes/CIP4 homology domain containing protein 0.0034 0.0002 0.0002
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0095 0.0036 0.1654
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0048 0.001 0.001
Loa Loa (eye worm) G-protein coupled receptor 0.0294 0.0146 0.0146
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0412 0.0211 0.0211
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0454 0.0234 0.3679
Echinococcus granulosus neuropeptide s receptor 0.0294 0.0146 0.0146
Onchocerca volvulus 0.0105 0.0042 0.169
Leishmania major hypothetical protein, conserved 0.0034 0.0002 0.0039
Onchocerca volvulus 0.0294 0.0146 0.6186
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0095 0.0036 1
Schistosoma mansoni sorting nexin 0.0034 0.0002 0.0002
Echinococcus granulosus tyrosine protein kinase Src42A 0.0355 0.018 0.018
Echinococcus granulosus expressed protein 0.0034 0.0002 0.0002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0294 0.0146 0.0146
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0294 0.0146 0.0146
Onchocerca volvulus 0.0454 0.0234 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0029 0.0029
Echinococcus granulosus tm gpcr rhodopsin 0.0294 0.0146 0.0146
Echinococcus multilocularis G-protein coupled receptor, putative 0.0294 0.0146 0.0146
Brugia malayi ORL1-like opioid receptor 0.0294 0.0146 0.0146
Brugia malayi G-protein coupled receptor 0.0294 0.0146 0.0146
Brugia malayi hypothetical protein 0.0294 0.0146 0.0146
Schistosoma mansoni hypothetical protein 0.0294 0.0146 0.0146
Brugia malayi Cytochrome P450 family protein 0.0329 0.0165 0.0165
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0095 0.0036 1
Loa Loa (eye worm) TK/FER protein kinase 0.0105 0.0042 0.0042
Loa Loa (eye worm) TK/FER protein kinase 0.0105 0.0042 0.0042
Entamoeba histolytica unconventional myosin IB 0.0034 0.0002 0.0107
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0412 0.0211 0.0211
Echinococcus granulosus cytochrome P450 2K1 0.0095 0.0036 0.0036
Schistosoma mansoni neuropeptide receptor 0.0294 0.0146 0.0146
Echinococcus granulosus suppressor of cytokine signaling 6 0.0082 0.0029 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0294 0.0146 0.0146
Echinococcus multilocularis SH2 motif 0.0082 0.0029 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0294 0.0146 0.0146
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0082 0.0029 0.0029
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0034 0.0002 0.0002
Echinococcus multilocularis tyrosine protein kinase Abl 0.014 0.0061 0.0061
Brugia malayi Protein kinase domain containing protein 0.0105 0.0042 0.0042
Onchocerca volvulus 0.0294 0.0146 0.6186
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0105 0.0042 0.0042
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0095 0.0036 1
Brugia malayi putative neuropeptide receptor NPR1 0.0294 0.0146 0.0146
Echinococcus granulosus acetylcholinesterase 0.0286 0.0141 0.0141
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0095 0.0036 0.1654
Loa Loa (eye worm) hypothetical protein 0.0048 0.001 0.001
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0095 0.0036 0.1654
Echinococcus granulosus neuropeptide Y receptor 0.0294 0.0146 0.0146
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0095 0.0036 0.0563
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Echinococcus multilocularis neuropeptide s receptor 0.0294 0.0146 0.0146
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0294 0.0146 0.0146
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0095 0.0036 0.1654
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Echinococcus multilocularis intersectin 2 0.0034 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Loa Loa (eye worm) melatonin receptor type 1A 0.0294 0.0146 0.0146
Entamoeba histolytica BAR/SH3 domain containing protein 0.0034 0.0002 0.0107
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0095 0.0036 1
Entamoeba histolytica protein kinase, putative 0.0454 0.0234 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0095 0.0036 0.1654
Loa Loa (eye worm) TK/FER protein kinase 0.0105 0.0042 0.0042
Onchocerca volvulus 0.0294 0.0146 0.6186
Schistosoma mansoni opsin-like receptor 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Schistosoma mansoni amine GPCR 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0082 0.0029 0.0029
Loa Loa (eye worm) STAT protein 0.0082 0.0029 0.0029
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0294 0.0146 0.0146
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0082 0.0029 0.0029
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0294 0.0146 0.0146
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0294 0.0146 0.0146
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0294 0.0146 0.0146
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0095 0.0036 0.1654
Echinococcus multilocularis dro:myosuppressin receptor 0.0294 0.0146 0.0146
Trypanosoma brucei conserved protein 0.0034 0.0002 0.0039
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0294 0.0146 0.0146
Loa Loa (eye worm) carboxylesterase 0.0048 0.001 0.001
Echinococcus multilocularis Spectrin alpha actinin 0.0034 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0034 0.0002 0.0002
Brugia malayi Carboxylesterase family protein 0.0286 0.0141 0.0141
Echinococcus multilocularis activin receptor type 0.0032 0.0001 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.0105 0.0042 0.0042
Schistosoma mansoni neuropeptide f receptor 76f 0.0294 0.0146 0.0146
Loa Loa (eye worm) TK/FER protein kinase 0.0105 0.0042 0.0042
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0034 0.0002 0.0002
Brugia malayi Protein kinase domain containing protein 0.0105 0.0042 0.0042
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0294 0.0146 0.0146
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0095 0.0036 1
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0034 0.0002 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0294 0.0146 0.0146
Schistosoma mansoni protein kinase 0.0032 0.0001 0.0001
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0095 0.0036 0.1654
Echinococcus granulosus 7TM GPCR rhodopsin 0.0294 0.0146 0.0146
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0002 0.0039
Echinococcus granulosus epidermal growth factor receptor kinase 0.0034 0.0002 0.0002
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0105 0.0042 0.1779
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Entamoeba histolytica protein kinase domain containing protein 0.0454 0.0234 1
Loa Loa (eye worm) thyroid receptor interactor 0.0034 0.0002 0.0002
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0082 0.0029 0.0029
Loa Loa (eye worm) neuropeptide F receptor 0.0294 0.0146 0.0146
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0095 0.0036 0.1654
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0294 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0294 0.0146 0.0146
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0048 0.001 0.0435
Loa Loa (eye worm) hypothetical protein 0.0048 0.001 0.001

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 100 uM Cytotoxicity against human K562 cells after 48 hrs by MTT assay ChEMBL. 23356786

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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