Detailed information for compound 1768624

Basic information

Technical information
  • TDR Targets ID: 1768624
  • Name: (3S,4R,5R,6R)-azepane-3,4,5,6-tetrol
  • MW: 163.172 | Formula: C6H13NO4
  • H donors: 5 H acceptors: 4 LogP: -2.9 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1[C@H](O)CNC[C@@H]([C@H]1O)O
  • InChi: 1S/C6H13NO4/c8-3-1-7-2-4(9)6(11)5(3)10/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
  • InChiKey: MRFFNLOQLBWKPJ-JGWLITMVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Alpha-L-fucosidase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni alpha-l-fucosidase Get druggable targets OG5_129683 All targets in OG5_129683
Brugia malayi Alpha-L-fucosidase family protein Get druggable targets OG5_129683 All targets in OG5_129683
Echinococcus multilocularis fucosidase, alpha L 1, tissue Get druggable targets OG5_129683 All targets in OG5_129683
Loa Loa (eye worm) alpha-L-fucosidase Get druggable targets OG5_129683 All targets in OG5_129683
Schistosoma japonicum ko:K01206 alpha-L-fucosidase [EC3.2.1.51], putative Get druggable targets OG5_129683 All targets in OG5_129683
Echinococcus granulosus fucosidase alpha L 1 tissue Get druggable targets OG5_129683 All targets in OG5_129683
Mycobacterium ulcerans alpha-L-fucosidase Get druggable targets OG5_129683 All targets in OG5_129683
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Alpha-L-fucosidase 1   468 aa 432 aa 43.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neuropeptide receptor 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0064 0.002 0.002
Brugia malayi follicle stimulating hormone receptor 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0066 0.0023 0.002
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1054 0.1628 0.1627
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0224 0.028 0.028
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Schistosoma mansoni sodium/chloride dependent transporter 0.6207 1 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0122 0.0115 0.0115
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0064 0.002 0.002
Brugia malayi neuropeptide F receptor 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Echinococcus granulosus peroxidasin 0.2789 0.4448 0.4448
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.002 0.002
Schistosoma mansoni hypothetical protein 0.051 0.0745 0.0744
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0056 0.0008 0.0007
Echinococcus granulosus g-protein coupled receptor 0.0064 0.002 0.002
Echinococcus granulosus neurogenic locus notch protein 0.051 0.0745 0.0745
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0064 0.002 0.002
Echinococcus granulosus short transient receptor potential channel 6 0.0072 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0122 0.0115 0.0111
Echinococcus granulosus neuropeptide Y receptor 0.0064 0.002 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0248 0.5396
Brugia malayi hypothetical protein 0.0064 0.002 0.002
Loa Loa (eye worm) Notch2 0.051 0.0745 0.0742
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0064 0.002 0.002
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0122 0.0115 0.0114
Loa Loa (eye worm) hypothetical protein 0.0255 0.033 0.0327
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Echinococcus granulosus neuropeptide FF receptor 2 0.0064 0.002 0.002
Brugia malayi hypothetical protein 0.0064 0.002 0.002
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0064 0.002 0.002
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.1054 0.1628 0.1625
Brugia malayi G-protein coupled receptor 0.0064 0.002 0.002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.002 0.002
Brugia malayi excitatory GABA receptor EXP-1A 0.0122 0.0115 0.0114
Brugia malayi Animal haem peroxidase family protein 0.2789 0.4448 0.4448
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0064 0.002 0.002
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0064 0.002 0.002
Onchocerca volvulus Neurogenic locus notch homolog 0.051 0.0745 0.0744
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0305 0.0412 0.9606
Brugia malayi hypothetical protein 0.0064 0.002 0.002
Loa Loa (eye worm) acetylcholine receptor protein 0.0056 0.0008 0.0004
Brugia malayi notch-like transmembrane receptor 0.051 0.0745 0.0744
Loa Loa (eye worm) hypothetical protein 0.2789 0.4448 0.4446
Echinococcus multilocularis serotonin receptor 0.0064 0.002 0.002
Echinococcus granulosus neuropeptide receptor 0.0064 0.002 0.002
Schistosoma mansoni peroxidasin 0.2789 0.4448 0.4448
Echinococcus multilocularis short transient receptor potential channel 6 0.0072 0.0033 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0266 0.5855
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0305 0.0412 0.2427
Brugia malayi sulfakinin receptor protein 0.0064 0.002 0.002
Onchocerca volvulus 0.051 0.0745 0.0744
Echinococcus multilocularis neuropeptide Y receptor 0.0064 0.002 0.002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.002 0.002
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0064 0.002 0.002
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0064 0.002 0.002
Echinococcus multilocularis G protein coupled receptor 139 0.0064 0.002 0.002
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.1054 0.1628 0.1627
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0064 0.002 0.002
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.1054 0.1628 0.1628
Loa Loa (eye worm) hypothetical protein 0.0056 0.0008 0.0004
Echinococcus multilocularis neuropeptide receptor 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Echinococcus granulosus 7TM GPCR rhodopsin 0.0064 0.002 0.002
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0305 0.0412 0.9591
Brugia malayi Tachykinin-like peptides receptor 99D 0.0064 0.002 0.002
Onchocerca volvulus 0.0064 0.002 0.002
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0224 0.028 0.028
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0268 0.0352 0.0351
Echinococcus granulosus sex peptide receptor 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0056 0.0008 0.0004
Echinococcus granulosus geminin 0.0183 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0056 0.0008 0.0004
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0064 0.002 0.002
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0122 0.0115 0.0114
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0056 0.0008 0.0008
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.033 0.033
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0064 0.002 0.002
Brugia malayi hypothetical protein 0.0224 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Loa Loa (eye worm) hypothetical protein 0.2789 0.4448 0.4446
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0056 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Loa Loa (eye worm) hypothetical protein 0.0066 0.0023 0.002
Echinococcus multilocularis dro:myosuppressin receptor 0.0064 0.002 0.002
Loa Loa (eye worm) GABA receptor subunit 0.0066 0.0023 0.002
Schistosoma mansoni cathepsin D (A01 family) 0.0224 0.028 0.028
Onchocerca volvulus Peroxidase homolog 0.2789 0.4448 0.4448
Toxoplasma gondii hypothetical protein 0.1054 0.1628 1
Schistosoma mansoni hypothetical protein 0.051 0.0745 0.0744
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0305 0.0412 0.5
Brugia malayi hypothetical protein 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0066 0.0023 0.002
Plasmodium vivax polyprenol reductase, putative 0.0305 0.0412 0.098
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Echinococcus granulosus glycine receptor subunit alpha 1 0.0122 0.0115 0.0115
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0224 0.028 0.028
Echinococcus multilocularis peroxidasin 0.2789 0.4448 0.4448
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.002 0.002
Plasmodium falciparum polyprenol reductase, putative 0.0305 0.0412 0.098
Brugia malayi Melatonin receptor type 1A 0.0064 0.002 0.002
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.1054 0.1628 0.1627
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0122 0.0115 0.0111
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0122 0.0115 0.0111
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.0083 0.0083
Schistosoma mansoni cell polarity protein 0.051 0.0745 0.0744
Onchocerca volvulus 0.0064 0.002 0.002
Schistosoma mansoni notch 0.051 0.0745 0.0744
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.002 0.002
Onchocerca volvulus 0.0064 0.002 0.002
Onchocerca volvulus 0.2789 0.4448 0.4448
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1054 0.1628 0.1627
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0056 0.0008 0.0007
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0066 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Toxoplasma gondii aspartyl protease ASP3 0.0224 0.028 0.1605
Schistosoma mansoni integrin alpha 0.021 0.0257 0.0257
Schistosoma mansoni amine GPCR 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0122 0.0115 0.0111
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.1054 0.1628 0.1628
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0305 0.0412 0.5
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.1054 0.1628 0.1625
Echinococcus granulosus nAChR subunit 0.0066 0.0023 0.0023
Brugia malayi Dopamine receptor protein 1 0.0064 0.002 0.002
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0305 0.0412 0.0412
Brugia malayi jmjC domain containing protein 0.0103 0.0083 0.0083
Schistosoma mansoni neurotransmitter gated ion channel 0.0056 0.0008 0.0007
Schistosoma mansoni transient receptor potential channel 0.0108 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0224 0.028 0.0277
Brugia malayi hypothetical protein 0.2789 0.4448 0.4448
Echinococcus granulosus uncharacterized sodium dependent transporter 0.1054 0.1628 0.1628
Echinococcus multilocularis neurogenic locus protein delta 0.051 0.0745 0.0745
Echinococcus multilocularis neurogenic locus notch protein 0.051 0.0745 0.0745
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.1054 0.1628 0.1627
Loa Loa (eye worm) hypothetical protein 0.0122 0.0115 0.0111
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0224 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0056 0.0008 0.0004
Schistosoma mansoni alpha-l-fucosidase 0.0469 0.0678 0.0677
Loa Loa (eye worm) animal heme peroxidase 0.2789 0.4448 0.4446
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0224 0.028 0.1605
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0305 0.0412 0.9591
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Onchocerca volvulus 0.0122 0.0115 0.0114
Loa Loa (eye worm) hypothetical protein 0.2789 0.4448 0.4446
Onchocerca volvulus 0.0122 0.0115 0.0114
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0224 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0122 0.0115 0.0111
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Echinococcus granulosus neuropeptides capa receptor 0.0064 0.002 0.002
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0224 0.028 0.028
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0423 0.9864
Onchocerca volvulus 0.1054 0.1628 0.1627
Brugia malayi hypothetical protein 0.0064 0.002 0.002
Plasmodium vivax hypothetical protein, conserved 0.1054 0.1628 1
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0022 0.0022
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0305 0.0412 0.2427
Echinococcus granulosus integrin alpha ps 0.0094 0.0069 0.0069
Onchocerca volvulus 0.0122 0.0115 0.0114
Echinococcus granulosus integrin alpha 3 0.0161 0.0177 0.0177
Schistosoma mansoni adenoreceptor 0.0064 0.002 0.002
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0305 0.0412 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.002 0.002
Brugia malayi Animal haem peroxidase family protein 0.2789 0.4448 0.4448
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0056 0.0008 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0428 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.002 0.002
Schistosoma mansoni nAChR subunit 0.0122 0.0115 0.0114
Schistosoma mansoni hypothetical protein 0.051 0.0745 0.0744
Echinococcus multilocularis neural cadherin 0.051 0.0745 0.0745
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0122 0.0115 0.0114
Schistosoma mansoni acetylcholine receptor-related 0.0056 0.0008 0.0007
Brugia malayi hypothetical protein 0.0056 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Brugia malayi Animal haem peroxidase family protein 0.2789 0.4448 0.4448
Echinococcus multilocularis nAChR subunit 0.0122 0.0115 0.0115
Echinococcus granulosus tumor protein p63 0.0332 0.0455 0.0455
Onchocerca volvulus 0.0064 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0064 0.002 0.002
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0305 0.0412 0.9591
Brugia malayi EGF-like domain containing protein 0.051 0.0745 0.0744
Schistosoma mansoni jumonji domain containing protein 0.0082 0.0049 0.0048
Onchocerca volvulus 0.0064 0.002 0.002
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Echinococcus multilocularis protein jagged 1 0.051 0.0745 0.0745
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0122 0.0115 0.0111
Mycobacterium ulcerans hypothetical protein 0.0305 0.0412 0.5946
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.002 0.002
Loa Loa (eye worm) solute carrier family 6 member 4 0.6207 1 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Echinococcus granulosus fmrfamide receptor 0.0064 0.002 0.002
Echinococcus granulosus glycine receptor subunit beta 0.0122 0.0115 0.0115
Echinococcus granulosus fucosidase alpha L 1 tissue 0.0469 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Echinococcus granulosus fibropellin Ia 0.051 0.0745 0.0745
Onchocerca volvulus 0.0122 0.0115 0.0114
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0066 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Brugia malayi Serotonin receptor 0.0064 0.002 0.002
Loa Loa (eye worm) G-protein coupled receptor 0.0064 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0305 0.0412 0.0409
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0268 0.0352 0.0352
Loa Loa (eye worm) hypothetical protein 0.0122 0.0115 0.0111
Echinococcus multilocularis fmrfamide receptor 0.0064 0.002 0.002
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0122 0.0115 0.0111
Schistosoma mansoni acetylcholine receptor subunit beta 0.0056 0.0008 0.0007
Entamoeba histolytica hypothetical protein 0.0305 0.0412 0.9606
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Loa Loa (eye worm) hypothetical protein 0.2789 0.4448 0.4446
Schistosoma mansoni biogenic amine receptor 0.0064 0.002 0.002
Schistosoma mansoni transient receptor potential channel 0.0072 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0305 0.0412 0.0409
Mycobacterium ulcerans alpha-L-fucosidase 0.0469 0.0678 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0008 0.0004
Echinococcus multilocularis neurogenic locus protein delta 0.051 0.0745 0.0745
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0305 0.0412 0.9606
Schistosoma mansoni cathepsin D (A01 family) 0.0224 0.028 0.028
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0122 0.0115 0.0114
Schistosoma mansoni notch 0.051 0.0745 0.0744
Brugia malayi Alpha-L-fucosidase family protein 0.0469 0.0678 0.0677
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.0038 0.0035
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0115 0.0114
Brugia malayi Pepsin A precursor 0.0224 0.028 0.028
Brugia malayi Animal haem peroxidase family protein 0.2789 0.4448 0.4448
Loa Loa (eye worm) blistered cuticle protein 3 0.2789 0.4448 0.4446
Onchocerca volvulus 0.0305 0.0412 0.0412
Echinococcus granulosus g protein coupled receptor 0.0064 0.002 0.002
Schistosoma mansoni neuropeptide receptor 0.0064 0.002 0.002
Onchocerca volvulus 0.0122 0.0115 0.0114
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0064 0.002 0.002
Echinococcus granulosus neuropeptide receptor A26 0.0064 0.002 0.002
Echinococcus multilocularis sodium and chloride dependent glycine 0.1054 0.1628 0.1628
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0154 0.0166 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0064 0.002 0.002
Schistosoma mansoni neuropeptide F-like receptor 0.0064 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0332 0.0455 0.0455
Schistosoma mansoni peroxidasin 0.2789 0.4448 0.4448
Schistosoma mansoni neuropeptide receptor 0.0064 0.002 0.002
Brugia malayi Delta serrate ligand family protein 0.051 0.0745 0.0744
Echinococcus multilocularis tumor protein p63 0.0332 0.0455 0.0455
Loa Loa (eye worm) notch protein 0.051 0.0745 0.0742
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.1054 0.1628 1
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.033 0.033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.002 0.002
Onchocerca volvulus 0.0224 0.028 0.028
Schistosoma mansoni neurotransmitter gated ion channel 0.0066 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Schistosoma mansoni alpha-1 adrenergic receptor 0.0064 0.002 0.002
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0268 0.0352 0.0352
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0423 0.9864
Loa Loa (eye worm) animal heme peroxidase 0.2789 0.4448 0.4446
Brugia malayi Integrin alpha pat-2 precursor 0.021 0.0257 0.0257
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0064 0.002 0.002
Onchocerca volvulus 0.0066 0.0023 0.0023
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0064 0.002 0.0016
Onchocerca volvulus 0.0224 0.028 0.028
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0115 0.0114
Toxoplasma gondii aspartyl protease 0.0224 0.028 0.1605
Loa Loa (eye worm) hypothetical protein 0.0122 0.0115 0.0111
Schistosoma mansoni hypothetical protein 0.0183 0.0213 0.0212
Schistosoma mansoni hypothetical protein 0.0064 0.002 0.002
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0224 0.028 0.028
Echinococcus multilocularis fmrfamide receptor 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.6207 1 1
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.1054 0.1628 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0064 0.002 0.002
Brugia malayi GCC2 and GCC3 family protein 0.051 0.0745 0.0744
Echinococcus granulosus serotonin receptor 0.0064 0.002 0.002
Brugia malayi hypothetical protein 0.0255 0.033 0.033
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0248 0.5396
Echinococcus granulosus peptide allatostatin:somatostatin 0.0064 0.002 0.002
Onchocerca volvulus Slit protein homolog 0.051 0.0745 0.0744
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.003 0.003
Schistosoma mansoni biogenic amine receptor 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0122 0.0115 0.0111
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0224 0.028 0.1605
Schistosoma mansoni histamine h1 receptor 0.0064 0.002 0.002
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0066 0.0023 0.0023
Brugia malayi EGF-like domain containing protein 0.051 0.0745 0.0744
Onchocerca volvulus Putative cubilin 0.051 0.0745 0.0744
Brugia malayi putative neuropeptide receptor 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0056 0.0008 0.0004
Brugia malayi Blistered cuticle protein 3 0.2789 0.4448 0.4448
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0428 1
Schistosoma mansoni notch 0.051 0.0745 0.0744
Loa Loa (eye worm) hypothetical protein 0.0056 0.0008 0.0004
Echinococcus granulosus uncharacterized sodium dependent transporter 0.1054 0.1628 0.1628
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0305 0.0412 0.098
Echinococcus multilocularis allatostatin A receptor 0.0064 0.002 0.002
Brugia malayi hypothetical protein 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0103 0.0083 0.0079
Onchocerca volvulus 0.0122 0.0115 0.0114
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0305 0.0412 0.9591
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0305 0.0412 0.9591
Echinococcus multilocularis sex peptide receptor 0.0064 0.002 0.002
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.1054 0.1628 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0122 0.0115 0.0115
Echinococcus multilocularis nAChR subunit 0.0066 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0066 0.0023 0.002
Schistosoma mansoni biogenic amine (5HT) receptor 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0056 0.0008 0.0004
Onchocerca volvulus 0.051 0.0745 0.0744
Loa Loa (eye worm) norepinephrine transporter 0.6207 1 1
Brugia malayi EGF-like domain containing protein 0.051 0.0745 0.0744
Loa Loa (eye worm) hypothetical protein 0.0116 0.0104 0.0101
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0064 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Brugia malayi hypothetical protein 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.002 0.002
Schistosoma mansoni nAChR subunit 0.0122 0.0115 0.0114
Echinococcus multilocularis snurportin 1 0.0332 0.0455 0.0455
Brugia malayi hypothetical protein 0.1054 0.1628 0.1627
Brugia malayi EGF-like domain containing protein 0.051 0.0745 0.0744
Brugia malayi larval opioid receptor 0.0064 0.002 0.002
Brugia malayi G-protein coupled receptor 0.0064 0.002 0.002
Onchocerca volvulus 0.1054 0.1628 0.1627
Echinococcus granulosus snurportin 1 0.0332 0.0455 0.0455
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0064 0.002 0.0016
Schistosoma mansoni hypothetical protein 0.007 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0056 0.0008 0.0004
Onchocerca volvulus 0.1054 0.1628 0.1627
Brugia malayi AKH receptor 0.0064 0.002 0.002
Loa Loa (eye worm) alpha-L-fucosidase 0.0469 0.0678 0.0674
Brugia malayi hypothetical protein 0.0056 0.0008 0.0007
Echinococcus granulosus neurogenic locus notch protein 0.051 0.0745 0.0745
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.2789 0.4448 0.4446
Loa Loa (eye worm) hypothetical protein 0.2789 0.4448 0.4446
Brugia malayi Cadherin domain containing protein 0.051 0.0745 0.0744
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.1054 0.1628 0.1625
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.0412 0.9591
Onchocerca volvulus 0.2789 0.4448 0.4448
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0266 0.5855
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0224 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0056 0.0008 0.0004
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0305 0.0412 0.5
Onchocerca volvulus 0.0064 0.002 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.002 0.002
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0305 0.0412 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0064 0.002 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1054 0.1628 0.1627
Echinococcus multilocularis fat cadherin tumor suppressor 0.051 0.0745 0.0745
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0423 0.9864
Echinococcus granulosus nAChR subunit 0.0122 0.0115 0.0115
Brugia malayi Heterochromatin protein 1 0.0075 0.0038 0.0038
Echinococcus granulosus 7tm_1 domain containing protein 0.0064 0.002 0.002
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.002 0.002
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0064 0.002 0.002
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0064 0.002 0.002
Schistosoma mansoni amine GPCR 0.0064 0.002 0.002
Echinococcus granulosus neuropeptides capa receptor 0.0064 0.002 0.002
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0056 0.0008 0.0008
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1054 0.1628 0.1627
Echinococcus granulosus glycine receptor subunit alpha 1 0.0122 0.0115 0.0115
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0305 0.0412 0.0412
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0224 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0122 0.0115 0.0111
Echinococcus granulosus allatostatin A receptor 0.0064 0.002 0.002
Echinococcus granulosus protein jagged 2 0.051 0.0745 0.0745
Loa Loa (eye worm) hypothetical protein 0.007 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0305 0.0412 0.2427
Echinococcus multilocularis transient receptor potential ion channel A 0.0101 0.008 0.008
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.1054 0.1628 0.1627
Schistosoma mansoni integrin alpha-ps 0.0094 0.0069 0.0068
Brugia malayi Calcium binding EGF domain containing protein 0.051 0.0745 0.0744
Echinococcus multilocularis protein jagged 1 0.051 0.0745 0.0745
Schistosoma mansoni hypothetical protein 0.051 0.0745 0.0744
Loa Loa (eye worm) animal heme peroxidase 0.2789 0.4448 0.4446
Schistosoma mansoni neuropeptide receptor 0.0064 0.002 0.002
Onchocerca volvulus 0.0064 0.002 0.002
Echinococcus granulosus notch 0.051 0.0745 0.0745
Schistosoma mansoni amine GPCR 0.0064 0.002 0.002
Toxoplasma gondii EGF family domain-containing protein 0.051 0.0745 0.45
Echinococcus granulosus short transient receptor potential channel 6 0.0072 0.0033 0.0033
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0066 0.0023 0.0023
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0122 0.0115 0.0115
Brugia malayi ORL1-like opioid receptor 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0268 0.0352 0.0348
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0428 1
Trichomonas vaginalis conserved hypothetical protein 0.0305 0.0412 0.9591
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0064 0.002 0.002
Brugia malayi Calcium binding EGF domain containing protein 0.051 0.0745 0.0744
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Echinococcus multilocularis orexin receptor type 2 0.0064 0.002 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0248 0.5396
Loa Loa (eye worm) hypothetical protein 0.1054 0.1628 0.1625
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Schistosoma mansoni sodium/chloride dependent transporter 0.1054 0.1628 0.1627
Echinococcus multilocularis transient receptor potential gamma protein 0.0108 0.0091 0.0091
Loa Loa (eye worm) LGC-31 protein 0.0122 0.0115 0.0111
Schistosoma mansoni chromobox protein 0.0075 0.0038 0.0038
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0064 0.002 0.002
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.1054 0.1628 1
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Brugia malayi Dopamine receptor protein 2 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.2789 0.4448 0.4446
Echinococcus granulosus neurogenic locus notch protein 4 0.051 0.0745 0.0745
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Brugia malayi hypothetical protein 0.0056 0.0008 0.0007
Echinococcus granulosus protein jagged 1 0.051 0.0745 0.0745
Schistosoma mansoni notch 0.051 0.0745 0.0744
Echinococcus multilocularis g protein coupled receptor 0.0064 0.002 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.002 0.002
Echinococcus granulosus chromobox protein 1 0.0075 0.0038 0.0038
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0122 0.0115 0.0114
Onchocerca volvulus 0.0064 0.002 0.002
Echinococcus multilocularis protein jagged 2 0.051 0.0745 0.0745
Onchocerca volvulus 0.0064 0.002 0.002
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0066 0.0023 0.0023
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.1054 0.1628 0.1627
Brugia malayi hypothetical protein 0.0056 0.0008 0.0007
Schistosoma mansoni nAChR subunit 0.0122 0.0115 0.0114
Loa Loa (eye worm) hypothetical protein 0.2789 0.4448 0.4446
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0021 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0248 0.5396
Brugia malayi Peroxidasin 0.2789 0.4448 0.4448
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0305 0.0412 0.0412
Brugia malayi Cation transporter family protein 0.0122 0.0115 0.0114
Brugia malayi EGF-like domain containing protein 0.051 0.0745 0.0744
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0315 0.0428 1
Echinococcus multilocularis neurogenic locus notch protein 4 0.051 0.0745 0.0745
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0064 0.002 0.002
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0122 0.0115 0.0115
Echinococcus granulosus tachykinin peptides receptor 99D 0.0064 0.002 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.002 0.002
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0122 0.0115 0.0111
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Onchocerca volvulus 0.051 0.0745 0.0744
Echinococcus granulosus protein jagged 1 0.051 0.0745 0.0745
Loa Loa (eye worm) hypothetical protein 0.0066 0.0023 0.002
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0224 0.028 0.028
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0122 0.0115 0.0114
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.051 0.0745 0.0744
Echinococcus multilocularis serotonin receptor 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0165 0.0184 0.018
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0064 0.002 0.002
Echinococcus granulosus glycine receptor subunit alpha 1 0.0122 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0056 0.0008 0.0004
Onchocerca volvulus Neuropeptide F receptor homolog 0.0064 0.002 0.002
Echinococcus granulosus hypothetical protein 0.0064 0.002 0.002
Brugia malayi Serotonin receptor 0.0064 0.002 0.002
Plasmodium falciparum amino acid transporter, putative 0.1054 0.1628 1
Onchocerca volvulus Peroxidasin homolog 0.2789 0.4448 0.4448
Echinococcus granulosus biogenic amine 5HT receptor 0.0064 0.002 0.002
Loa Loa (eye worm) ACC-1 protein 0.0122 0.0115 0.0111
Schistosoma mansoni nAChR subunit 0.0122 0.0115 0.0114
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0122 0.0115 0.0115
Brugia malayi Cation transporter family protein 0.0122 0.0115 0.0114
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0428 1
Brugia malayi GnHR receptor homolog 0.0064 0.002 0.002
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0122 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0224 0.028 0.0277
Echinococcus granulosus protein jagged 2 0.051 0.0745 0.0745
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0122 0.0115 0.0114
Loa Loa (eye worm) hypothetical protein 0.1054 0.1628 0.1625
Echinococcus multilocularis neuropeptides capa receptor 0.0064 0.002 0.002
Schistosoma mansoni sodium-dependent amino acid transporter 0.1054 0.1628 0.1627
Echinococcus multilocularis short transient receptor potential channel 6 0.0072 0.0033 0.0033
Brugia malayi Synaptic glycoprotein SC2 0.0305 0.0412 0.0412
Brugia malayi Dopamine receptor 0.0064 0.002 0.002
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0224 0.028 0.0277
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0122 0.0115 0.0115
Plasmodium falciparum transporter, putative 0.1054 0.1628 1
Onchocerca volvulus 0.0064 0.002 0.002
Schistosoma mansoni sodium/chloride dependent transporter 0.1054 0.1628 0.1627
Schistosoma mansoni slit 0.051 0.0745 0.0744
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Echinococcus granulosus neurogenic locus protein delta 0.051 0.0745 0.0745
Onchocerca volvulus 0.0064 0.002 0.002
Onchocerca volvulus 0.0064 0.002 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0248 0.5396
Echinococcus granulosus sodium and chloride dependent glycine 0.1054 0.1628 0.1628
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0122 0.0115 0.0115
Onchocerca volvulus Neurogenic locus notch protein homolog 0.051 0.0745 0.0744
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.051 0.0745 0.0744
Echinococcus multilocularis g protein coupled receptor 0.0064 0.002 0.002
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0122 0.0115 0.0114
Loa Loa (eye worm) hypothetical protein 0.2789 0.4448 0.4446
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0064 0.002 0.0016
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0206 0.025 0.544
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0064 0.002 0.0016
Echinococcus multilocularis neuropeptide FF receptor 2 0.0064 0.002 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0423 0.9864
Onchocerca volvulus Dual oxidase homolog 0.2789 0.4448 0.4448
Loa Loa (eye worm) hypothetical protein 0.0305 0.0412 0.0409
Onchocerca volvulus Chorion peroxidase homolog 0.2789 0.4448 0.4448
Loa Loa (eye worm) hypothetical protein 0.0056 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Schistosoma mansoni biogenic amine (5HT) receptor 0.0064 0.002 0.002
Echinococcus multilocularis synaptic glycoprotein sc2 0.0305 0.0412 0.0412
Echinococcus multilocularis somatostatin receptor 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Echinococcus granulosus neuropeptide s receptor 0.0064 0.002 0.002
Brugia malayi G protein-coupled receptor 0.0064 0.002 0.002
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.002 0.002
Schistosoma mansoni laminin gamma-3 chain 0.051 0.0745 0.0744
Loa Loa (eye worm) G-protein coupled receptor 0.0064 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.1054 0.1628 0.1625
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0206 0.025 0.544
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Brugia malayi EGF-like domain containing protein 0.051 0.0745 0.0744
Loa Loa (eye worm) hypothetical protein 0.2789 0.4448 0.4446
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0122 0.0115 0.0114
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.1054 0.1628 0.1628
Toxoplasma gondii hypothetical protein 0.1054 0.1628 1
Loa Loa (eye worm) hypothetical protein 0.2789 0.4448 0.4446
Brugia malayi hypothetical protein 0.0064 0.002 0.002
Echinococcus multilocularis integrin alpha ps 0.0094 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0066 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.6207 1 1
Schistosoma mansoni notch 0.051 0.0745 0.0744
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0122 0.0115 0.0115
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0064 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0157 0.0171 0.0168
Loa Loa (eye worm) hypothetical protein 0.0122 0.0115 0.0111
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.1054 0.1628 0.1627
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.002 0.002
Schistosoma mansoni notch 0.051 0.0745 0.0744
Schistosoma mansoni opsin-like receptor 0.0064 0.002 0.002
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0064 0.002 0.002
Brugia malayi Muscle positioning protein 4 0.051 0.0745 0.0744
Onchocerca volvulus 0.6207 1 1
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.0248 0.0248
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0115 0.0114
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Schistosoma mansoni chromobox protein 0.0075 0.0038 0.0038
Echinococcus multilocularis chromobox protein 1 0.0075 0.0038 0.0038
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0428 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0122 0.0115 0.0114
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0268 0.0352 0.0352
Echinococcus granulosus orexin receptor type 2 0.0064 0.002 0.002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0122 0.0115 0.0111
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0066 0.0023 0.0023
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.0423 0.0419
Brugia malayi Calcium binding EGF domain containing protein 0.051 0.0745 0.0744
Brugia malayi aspartic protease BmAsp-1, identical 0.0224 0.028 0.028
Echinococcus multilocularis G-protein coupled receptor, putative 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Onchocerca volvulus 0.2789 0.4448 0.4448
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0305 0.0412 0.9591
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.0469 0.0678 0.0678
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.002 0.002
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0064 0.002 0.002
Onchocerca volvulus 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.2789 0.4448 0.4446
Echinococcus granulosus biogenic amine 5HT receptor 0.0064 0.002 0.002
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0064 0.002 0.002
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0122 0.0115 0.0115
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0108 0.0091 0.0088
Giardia lamblia Fructose-bisphosphate aldolase 0.0315 0.0428 0.0479
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0332 0.0455 0.0452
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.002 0.002
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0056 0.0008 0.0008
Echinococcus granulosus alpha 1A adrenergic receptor 0.0064 0.002 0.002
Loa Loa (eye worm) aspartyl protease 6 0.0224 0.028 0.0277
Loa Loa (eye worm) hypothetical protein 0.0122 0.0115 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0423 0.9864
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0423 0.9864
Echinococcus granulosus chromobox protein 1 0.0075 0.0038 0.0038
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.002 0.002
Schistosoma mansoni hypothetical protein 0.051 0.0745 0.0744
Echinococcus granulosus g protein coupled receptor 0.0064 0.002 0.002
Echinococcus multilocularis sodium and chloride dependent glycine 0.1054 0.1628 0.1628
Loa Loa (eye worm) hypothetical protein 0.1054 0.1628 0.1625
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0268 0.0352 0.0352
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0115 0.0114
Echinococcus multilocularis slit 2 protein 0.051 0.0745 0.0745
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0122 0.0115 0.0114
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0305 0.0412 0.9591
Echinococcus multilocularis neuropeptide receptor 0.0064 0.002 0.002
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.1054 0.1628 0.1628
Loa Loa (eye worm) hypothetical protein 0.0066 0.0023 0.002
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.002 0.002
Loa Loa (eye worm) neuropeptide F receptor 0.0064 0.002 0.0016
Echinococcus multilocularis g protein coupled receptor 0.0064 0.002 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0248 0.5396
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0428 1
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0056 0.0008 0.0008
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0268 0.0352 0.0352
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Echinococcus granulosus g protein coupled receptor 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0224 0.028 0.0277
Schistosoma mansoni nAChR subunit 0.0122 0.0115 0.0114
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Onchocerca volvulus 0.0064 0.002 0.002
Loa Loa (eye worm) ACC-1 protein 0.0122 0.0115 0.0111
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0064 0.002 0.002
Echinococcus granulosus dro:myosuppressin receptor 0.0064 0.002 0.002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0008 0.0007
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0056 0.0008 0.0004
Echinococcus multilocularis geminin 0.0183 0.0213 0.0213
Schistosoma mansoni amine GPCR 0.0064 0.002 0.002
Brugia malayi putative neuropeptide receptor NPR1 0.0064 0.002 0.002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0115 0.0114
Loa Loa (eye worm) hypothetical protein 0.0056 0.0008 0.0004
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0154 0.0166 1
Schistosoma mansoni nAChR subunit 0.0122 0.0115 0.0114
Loa Loa (eye worm) hypothetical protein 0.0066 0.0023 0.0019
Brugia malayi EGF-like domain containing protein 0.051 0.0745 0.0744
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0305 0.0412 0.0412
Echinococcus granulosus delta-like protein 1 0.051 0.0745 0.0745
Loa Loa (eye worm) hypothetical protein 0.6207 1 1
Onchocerca volvulus 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Loa Loa (eye worm) integrin alpha pat-2 0.021 0.0257 0.0254
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0122 0.0115 0.0111
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0224 0.028 0.0277
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0428 1
Brugia malayi RE15519p 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.2789 0.4448 0.4446
Echinococcus multilocularis neuropeptide Y receptor 0.0064 0.002 0.002
Echinococcus granulosus serotonin transporter 0.6207 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0248 0.5396
Schistosoma mansoni hypothetical protein 0.051 0.0745 0.0744
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0064 0.002 0.002
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0064 0.002 0.002
Echinococcus multilocularis glycine receptor subunit beta 0.0122 0.0115 0.0115
Loa Loa (eye worm) animal heme peroxidase 0.2789 0.4448 0.4446
Loa Loa (eye worm) neuropeptide F receptor 0.0064 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0122 0.0115 0.0111
Schistosoma mansoni nAChR subunit 0.0122 0.0115 0.0114
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0122 0.0115 0.0114
Echinococcus granulosus neuropeptide receptor 0.0064 0.002 0.002
Echinococcus multilocularis fibropellin Ia 0.051 0.0745 0.0745
Brugia malayi aspartic protease BmAsp-2, identical 0.0224 0.028 0.028
Schistosoma mansoni myosin xvIII 0.0064 0.002 0.002
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0122 0.0115 0.0114
Onchocerca volvulus Peroxidasin homolog 0.2789 0.4448 0.4448
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0056 0.0008 0.0004
Giardia lamblia High cysteine protein 0.051 0.0745 1
Onchocerca volvulus 0.0056 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0122 0.0115 0.0111
Plasmodium vivax amine transporter, putative 0.1054 0.1628 1
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0022 0.0022
Treponema pallidum sodium- and chloride- dependent transporter 0.6207 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0064 0.002 0.002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.002 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.002 0.002
Echinococcus multilocularis serotonin transporter 0.6207 1 1
Schistosoma mansoni amine GPCR 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0122 0.0115 0.0115
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0315 0.0428 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0122 0.0115 0.0114
Echinococcus granulosus G protein coupled receptor 139 0.0064 0.002 0.002
Brugia malayi Cation transporter family protein 0.0122 0.0115 0.0114
Brugia malayi Eukaryotic aspartyl protease family protein 0.0224 0.028 0.028
Brugia malayi Animal haem peroxidase family protein 0.2789 0.4448 0.4448
Schistosoma mansoni opsin-like receptor 0.0064 0.002 0.002
Loa Loa (eye worm) serotonin transporter b 0.6207 1 1
Schistosoma mansoni hypothetical protein 0.0183 0.0213 0.0212
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0122 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Echinococcus multilocularis integrin alpha 3 0.0161 0.0177 0.0177
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0022 0.0022
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.1054 0.1628 0.1627
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.6207 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0083 0.0082
Echinococcus granulosus neural cadherin 0.051 0.0745 0.0745
Brugia malayi neuropeptide F receptor 0.0064 0.002 0.002
Echinococcus multilocularis glycine receptor subunit beta 0.0122 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.1054 0.1628 0.1625
Onchocerca volvulus 0.0056 0.0008 0.0007
Onchocerca volvulus 0.051 0.0745 0.0744
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0268 0.0352 0.0352
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0022 0.0539
Loa Loa (eye worm) hypothetical protein 0.0056 0.0008 0.0004
Loa Loa (eye worm) TYRA-2 protein 0.0064 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.2789 0.4448 0.4446
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0122 0.0115 0.0111
Schistosoma mansoni nAChR subunit 0.0056 0.0008 0.0007
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0305 0.0412 0.0412
Brugia malayi Cadherin domain containing protein 0.051 0.0745 0.0744
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0083 0.0082
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.002 0.002
Echinococcus multilocularis integrin alpha ps 0.0094 0.0069 0.0069
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0305 0.0412 0.9606
Echinococcus multilocularis neurogenic locus notch protein 0.051 0.0745 0.0745
Echinococcus granulosus transient receptor potential ion channel A 0.0101 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0122 0.0115 0.0111
Schistosoma mansoni neuropeptide F-like receptor 0.0064 0.002 0.002
Brugia malayi hypothetical protein 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0066 0.0023 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Echinococcus multilocularis neuropeptides capa receptor 0.0064 0.002 0.002
Echinococcus granulosus synaptic glycoprotein sc2 0.0305 0.0412 0.0412
Onchocerca volvulus Putative nachr subunit 0.0268 0.0352 0.0351
Echinococcus granulosus transient receptor potential gamma protein 0.0108 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0122 0.0115 0.0111
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0122 0.0115 0.0114
Schistosoma mansoni biogenic amine receptor 0.0064 0.002 0.002
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0224 0.028 0.6205
Brugia malayi G protein-coupled receptor F59B2.13 0.0064 0.002 0.002
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1054 0.1628 0.1627
Onchocerca volvulus 0.0066 0.0023 0.0023
Echinococcus granulosus neuropeptide Y receptor 0.0064 0.002 0.002
Onchocerca volvulus 0.0064 0.002 0.002
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0224 0.028 0.028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0315 0.0428 1
Onchocerca volvulus Peroxidase homolog 0.2789 0.4448 0.4448
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0056 0.0008 0.0007
Onchocerca volvulus 0.0056 0.0008 0.0007
Schistosoma mansoni hypothetical protein 0.051 0.0745 0.0744
Echinococcus multilocularis notch 0.051 0.0745 0.0745
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0268 0.0352 0.0348
Schistosoma mansoni growth hormone secretagogue receptor 0.0064 0.002 0.002
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0154 0.0166 0.2193
Brugia malayi hypothetical protein 0.0224 0.028 0.028
Loa Loa (eye worm) melatonin receptor type 1A 0.0064 0.002 0.0016
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.0423 0.0422
Toxoplasma gondii aspartyl protease ASP1 0.0224 0.028 0.1605
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.051 0.0745 0.0742
Brugia malayi hypothetical protein 0.0064 0.002 0.002
Echinococcus granulosus slit 2 protein 0.051 0.0745 0.0745
Onchocerca volvulus 0.0064 0.002 0.002
Schistosoma mansoni memapsin-2 (A01 family) 0.5579 0.898 0.898
Loa Loa (eye worm) hypothetical protein 0.0064 0.002 0.0016
Schistosoma mansoni septate junction protein 0.051 0.0745 0.0744
Echinococcus multilocularis chromobox protein 1 0.0075 0.0038 0.0038
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.1054 0.1628 0.1628
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0122 0.0115 0.0114
Onchocerca volvulus 0.051 0.0745 0.0744
Echinococcus granulosus glycine receptor subunit beta 0.0122 0.0115 0.0115
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.002 0.002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0083 0.0079
Loa Loa (eye worm) hypothetical protein 0.0122 0.0115 0.0111
Brugia malayi RNA, U transporter 1 0.0088 0.0059 0.0059
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0305 0.0412 0.5
Loa Loa (eye worm) hypothetical protein 0.1054 0.1628 0.1625
Loa Loa (eye worm) hypothetical protein 0.0056 0.0008 0.0004
Schistosoma mansoni nAChR subunit 0.0056 0.0008 0.0007
Schistosoma mansoni opsin-like receptor 0.0064 0.002 0.002
Schistosoma mansoni transient receptor potential channel 0.0072 0.0033 0.0033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.002 0.002
Echinococcus multilocularis neuropeptide receptor A26 0.0064 0.002 0.002
Echinococcus granulosus somatostatin receptor 0.0064 0.002 0.002
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0305 0.0412 0.098
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0064 0.002 0.002
Schistosoma mansoni transient receptor potential channel 4 0.0108 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0066 0.0023 0.002
Brugia malayi hypothetical protein 0.0056 0.0008 0.0007
Echinococcus granulosus sodium and chloride dependent glycine 0.1054 0.1628 0.1628
Schistosoma mansoni neurotransmitter gated ion channel 0.0056 0.0008 0.0007

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 4.6 uM Inhibition of bovine kidney alpha-L-fucosidase ChEMBL. 23611766
Ki (binding) = 54 uM Inhibition of coffee bean alpha-galactosidase ChEMBL. 23611766

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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