Detailed information for compound 1768663

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 353.458 | Formula: C21H27N3O2
  • H donors: 2 H acceptors: 2 LogP: 1.93 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1Cc2c(C[C@H]1N1CCC(CC1)C(=O)c1cccn1C)cccc2N
  • InChi: 1S/C21H27N3O2/c1-23-9-3-6-18(23)21(26)14-7-10-24(11-8-14)19-12-15-4-2-5-17(22)16(15)13-20(19)25/h2-6,9,14,19-20,25H,7-8,10-13,22H2,1H3/t19-,20-/m1/s1
  • InChiKey: XBRHTDSVNIIZNF-WOJBJXKFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 18 (vesicular acetylcholine transporter), member 3 Starlite/ChEMBL References
Cavia porcellus Sigma-1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Echinococcus multilocularis vesicular acetylcholine transporter Get druggable targets OG5_133283 All targets in OG5_133283
Brugia malayi ERG2 and Sigma1 receptor like protein Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Schistosoma japonicum ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative Get druggable targets OG5_133283 All targets in OG5_133283
Brugia malayi vesicular acetylcholine transporter unc-17 Get druggable targets OG5_133283 All targets in OG5_133283
Leishmania infantum C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei gambiense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania major C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Echinococcus granulosus vesicular acetylcholine transporter Get druggable targets OG5_133283 All targets in OG5_133283
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Onchocerca volvulus Vesicular acetylcholine transporter homolog Get druggable targets OG5_133283 All targets in OG5_133283
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 Get druggable targets OG5_133283 All targets in OG5_133283
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma cruzi C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania donovani C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania mexicana C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Schistosoma mansoni vesicular acetylcholine transporter Get druggable targets OG5_133283 All targets in OG5_133283
Trypanosoma brucei C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Abnormal catecholamine distribution protein 1 solute carrier family 18 (vesicular acetylcholine transporter), member 3 532 aa 504 aa 34.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0038 0.025 0.0565
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0377 0.1816
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0454 0.8713
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.0135 0.0127
Brugia malayi jmjC domain containing protein 0.0059 0.0455 0.1046
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0026 0.0348
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.0135 0.0296
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.0021 0.0245
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0102 0.0883 0.4251
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0217 0.0909
Loa Loa (eye worm) hypothetical protein 0.0085 0.072 0.1666
Loa Loa (eye worm) hypothetical protein 0.0059 0.0453 0.1041
Echinococcus multilocularis Smad4 0.0016 0.0033 0.0025
Brugia malayi larval opioid receptor 0.0026 0.0135 0.0296
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0021 0.009
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.0023 0.0058
Trypanosoma cruzi trypanothione reductase, putative 0.0045 0.0315 0.0719
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0026 0.0053
Loa Loa (eye worm) hypothetical protein 0.0051 0.0377 0.0863
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.0135 0.0127
Onchocerca volvulus 0.0026 0.0135 0.0456
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.0135 0.0296
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Echinococcus granulosus hypothetical protein 0.0026 0.0135 0.0127
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0103 0.0095
Leishmania major DNA polymerase kappa, putative 0.0019 0.0062 0.0126
Brugia malayi intermediate filament protein 0.006 0.0464 0.1067
Echinococcus granulosus low density lipoprotein receptor ldl 0.0085 0.072 0.0713
Entamoeba histolytica acyl-CoA synthetase, putative 0.0051 0.0377 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.0135 0.0296
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0038 0.025 0.1739
Schistosoma mansoni cpg binding protein 0.0036 0.0228 0.0258
Schistosoma mansoni adenoreceptor 0.0026 0.0135 0.0148
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0021 0.009
Schistosoma mansoni rab6-interacting 0.0023 0.0103 0.0112
Brugia malayi hypothetical protein 0.0051 0.0377 0.0863
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0135 0.0127
Plasmodium vivax acyl-CoA synthetase, putative 0.0038 0.025 0.6429
Schistosoma mansoni survival motor neuron protein 0.0047 0.0335 0.0383
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0062 0.0137
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0102 0.0883 0.4251
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.0135 0.0148
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0023 0.0015
Echinococcus multilocularis neuropeptide receptor A26 0.1021 1 1
Schistosoma mansoni polycystin 1-related 0.0023 0.0103 0.0112
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.0135 0.0127
Schistosoma mansoni smad1 5 8 and 0.0016 0.0033 0.003
Onchocerca volvulus 0.003 0.017 0.0599
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0217 0.1047
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0062 0.0191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0135 0.0148
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0135 0.0127
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0033 0.0059
Schistosoma mansoni loxhd1 0.0023 0.0103 0.0112
Loa Loa (eye worm) hypothetical protein 0.0227 0.2127 0.4956
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.017 0.019
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.0135 0.0296
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.176 0.2055
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0135 0.0127
Loa Loa (eye worm) hypothetical protein 0.0028 0.0147 0.0325
Schistosoma mansoni hypothetical protein 0.0483 0.4662 0.5458
Loa Loa (eye worm) intermediate filament protein 0.006 0.0464 0.1067
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0229 0.1103
Schistosoma mansoni opsin-like receptor 0.0026 0.0135 0.0148
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0026 0.0042
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0135 0.0296
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0135 0.0127
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0014 0.0008 0.0039
Onchocerca volvulus 0.0233 0.2185 0.8658
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.017 0.019
Onchocerca volvulus 0.0026 0.0135 0.0456
Loa Loa (eye worm) hypothetical protein 0.0038 0.025 0.0565
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.0135 0.0296
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0135 0.0296
Echinococcus multilocularis dnaJ subfamily B 0.0483 0.4662 0.4658
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0377 0.0873
Echinococcus granulosus geminin 0.0873 0.8535 0.8534
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.0135 0.0148
Leishmania major hypothetical protein, conserved 0.0051 0.0377 0.0863
Onchocerca volvulus 0.0026 0.0135 0.0456
Echinococcus multilocularis cpg binding protein 0.0036 0.0228 0.022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0135 0.0148
Brugia malayi hypothetical protein 0.0026 0.0135 0.0296
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0015 0.0021 0.009
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.0021 0.0041
Leishmania major hypothetical protein, conserved 0.0015 0.0023 0.0034
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0335 0.0764
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0135 0.0148
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0026 0.0135 0.0456
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0015 0.0021 0.009
Echinococcus granulosus vesicular acetylcholine transporter 0.0267 0.2521 0.2515
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0103 0.0095
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Brugia malayi MH1 domain containing protein 0.0016 0.0033 0.0059
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0135 0.0127
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0026 0.0135 0.0296
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0085 0.072 0.1666
Schistosoma mansoni lamin 0.006 0.0464 0.0535
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.0135 0.0296
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.0135 0.0127
Schistosoma mansoni lipoxygenase 0.0139 0.1254 0.1461
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0103 0.0095
Schistosoma mansoni hypothetical protein 0.0023 0.0103 0.0112
Loa Loa (eye worm) hypothetical protein 0.0085 0.072 0.1666
Echinococcus granulosus orexin receptor type 2 0.0026 0.0135 0.0127
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.0135 0.0296
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.2139 0.2132
Brugia malayi hypothetical protein 0.0145 0.1307 0.3038
Echinococcus multilocularis lamin 0.006 0.0464 0.0456
Giardia lamblia DINP protein human, muc B family 0.0019 0.0062 1
Echinococcus multilocularis smad 0.0016 0.0033 0.0025
Echinococcus granulosus dna polymerase kappa 0.0019 0.0062 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0137
Brugia malayi Cytochrome P450 family protein 0.0051 0.0374 0.0855
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.4284 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.0135 0.0127
Brugia malayi CUB domain containing protein 0.0085 0.072 0.1666
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0062 0.0126
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0026 0.0024
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0135 0.0127
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0062 0.0063
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.0135 0.0148
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0014 0.0008 0.0039
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.7644 0.7642
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0085 0.072 0.0713
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0015 0.0021 0.0127
Brugia malayi Smad1 0.0016 0.0033 0.0059
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0099 0.0091
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0113 0.0996 0.4794
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0229 0.1103
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0377 0.2658
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0377 0.0863
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0062 0.0137
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.0135 0.0148
Onchocerca volvulus 0.0023 0.0103 0.0331
Leishmania major trypanothione reductase 0.0045 0.0315 0.0719
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0279 0.0645
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0021 0.0099
Echinococcus multilocularis allatostatin A receptor 0.0026 0.0135 0.0127
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0526 0.1212
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0062 0.0298
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0026 0.0053
Entamoeba histolytica acyl-CoA synthetase, putative 0.0051 0.0377 1
Brugia malayi hypothetical protein 0.0228 0.2139 0.4983
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0135 0.0127
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.0135 0.0127
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0014 0.0008 0.0039
Onchocerca volvulus 0.0085 0.072 0.2798
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0014 0.0008 0.0039
Schistosoma mansoni neuropeptide receptor 0.0026 0.0135 0.0148
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0021 0.0099
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0135 0.0127
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.2139 0.2132
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0158 0.015
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0021 0.009
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0014 0.0008 0.0039
Echinococcus granulosus somatostatin receptor 0.0026 0.0135 0.0127
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Echinococcus granulosus dnaJ subfamily B 0.0483 0.4662 0.4658
Schistosoma mansoni hypothetical protein 0.0026 0.0135 0.0148
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0085 0.072 0.1666
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0526 0.1212
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0135 0.0148
Schistosoma mansoni smad1 5 8 and 0.0016 0.0033 0.003
Loa Loa (eye worm) hypothetical protein 0.0051 0.0377 0.0863
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.2233 0.5204
Brugia malayi neuropeptide F receptor 0.0026 0.0135 0.0296
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.0135 0.0296
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.1397 0.6726
Echinococcus multilocularis somatostatin receptor 0.0026 0.0135 0.0127
Mycobacterium ulcerans hypothetical protein 0.0051 0.0377 0.2658
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0021 0.009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0135 0.0127
Echinococcus multilocularis sex peptide receptor 0.0026 0.0135 0.0127
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0033 0.0025
Onchocerca volvulus 0.0085 0.072 0.2798
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Echinococcus granulosus basement membrane specific heparan sulfate 0.0085 0.072 0.0713
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0014 0.0008 0.0039
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0454 0.2187
Onchocerca volvulus 0.0026 0.0135 0.0456
Schistosoma mansoni Smad4 0.0016 0.0033 0.003
Echinococcus granulosus cpg binding protein 0.0036 0.0228 0.022
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0026 0.0148
Loa Loa (eye worm) hypothetical protein 0.0085 0.072 0.1666
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.0135 0.0127
Loa Loa (eye worm) beta-lactamase 0.0035 0.0217 0.049
Echinococcus granulosus g-protein coupled receptor 0.0026 0.0135 0.0127
Schistosoma mansoni hypothetical protein 0.0085 0.072 0.0835
Brugia malayi beta-lactamase family protein 0.0035 0.0217 0.049
Loa Loa (eye worm) oxidoreductase 0.0015 0.0021 0.0029
Onchocerca volvulus 0.0085 0.072 0.2798
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0026 0.0042
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0135 0.0148
Toxoplasma gondii propionate-CoA ligase 0.0015 0.0021 0.0245
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0033 0.0059
Brugia malayi beta-lactamase family protein 0.0035 0.0217 0.049
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0103 0.0095
Schistosoma mansoni amine GPCR 0.0026 0.0135 0.0148
Onchocerca volvulus 0.0026 0.0135 0.0456
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0062 0.0126
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0085 0.072 0.1666
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0135 0.0148
Echinococcus granulosus lamin 0.006 0.0464 0.0456
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0021 0.009
Loa Loa (eye worm) hypothetical protein 0.0085 0.072 0.1666
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0021 0.0029
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.4284 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0208 0.1939 0.4515
Brugia malayi putative neuropeptide receptor 0.0026 0.0135 0.0296
Mycobacterium tuberculosis Probable dehydrogenase 0.0102 0.0883 0.4251
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0377 0.0863
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0135 0.0296
Onchocerca volvulus 0.0026 0.0135 0.0456
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0377 0.0863
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0023 0.0046
Schistosoma mansoni lamin 0.006 0.0464 0.0535
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.0135 0.0148
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0026 0.0042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.176 0.1753
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0085 0.072 0.0713
Trichomonas vaginalis set domain proteins, putative 0.0233 0.2185 1
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0015 0.0021 0.0127
Onchocerca volvulus 0.0026 0.0135 0.0456
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0135 0.0127
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0021 0.0099
Schistosoma mansoni cpg binding protein 0.0034 0.0209 0.0235
Loa Loa (eye worm) hypothetical protein 0.0035 0.0217 0.049
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0526 0.0519
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.2233 0.5204
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0135 0.0148
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0026 0.5
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0021 0.0029
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0023 0.0034
Plasmodium falciparum thioredoxin reductase 0.0045 0.0315 0.8274
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0137
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0026 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0021 0.0099
Brugia malayi RE15519p 0.0026 0.0135 0.0296
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0021 0.0029
Schistosoma mansoni smad 0.0016 0.0033 0.003
Brugia malayi MH1 domain containing protein 0.0016 0.0033 0.0059
Brugia malayi Dopamine receptor 0.0026 0.0135 0.0296
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0085 0.072 0.0835
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0135 0.0127
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0454 0.3213
Loa Loa (eye worm) hypothetical protein 0.0145 0.1307 0.3038
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0217 0.0909
Schistosoma mansoni myosin xvIII 0.0026 0.0135 0.0148
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0217 0.049
Loa Loa (eye worm) hypothetical protein 0.0035 0.0217 0.049
Onchocerca volvulus 0.0026 0.0135 0.0456
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.176 0.2055
Loa Loa (eye worm) hypothetical protein 0.0038 0.025 0.0565
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0085 0.072 0.1666
Brugia malayi hypothetical protein 0.0033 0.0198 0.0444
Loa Loa (eye worm) hypothetical protein 0.0085 0.072 0.1666
Echinococcus granulosus sex peptide receptor 0.0026 0.0135 0.0127
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.2767 0.6452
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.2767 0.6452
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0034
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0026 0.0042
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0436 0.0428
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0085 0.072 0.2798
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0021 0.0099
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0042 0.0034
Brugia malayi GnHR receptor homolog 0.0026 0.0135 0.0296
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.0135 0.0127
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Schistosoma mansoni biogenic amine receptor 0.0026 0.0135 0.0148
Loa Loa (eye worm) hypothetical protein 0.0028 0.0147 0.0325
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0062 0.0126
Loa Loa (eye worm) hypothetical protein 0.006 0.0464 0.1067
Onchocerca volvulus Huntingtin homolog 0.0145 0.1307 0.5145
Mycobacterium ulcerans hypothetical protein 0.0035 0.0217 0.1508
Plasmodium falciparum glutathione reductase 0.0045 0.0315 0.8274
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0454 0.0447
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.0135 0.0127
Schistosoma mansoni hypothetical protein 0.0066 0.0526 0.0608
Onchocerca volvulus 0.0026 0.0135 0.0456
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0135 0.0127
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.0135 0.0296
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0021 0.0013
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0085 0.072 0.1666
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0135 0.0127
Brugia malayi jmjC domain containing protein 0.0057 0.0436 0.1001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0217 0.049
Schistosoma mansoni intermediate filament proteins 0.006 0.0464 0.0535
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0062 0.0126
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.0135 0.0296
Brugia malayi MH2 domain containing protein 0.0016 0.0033 0.0059
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0103 0.0095
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.0135 0.0148
Brugia malayi Dopamine receptor protein 1 0.0026 0.0135 0.0296
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0015 0.0021 0.009
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0455 0.1046
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0377 0.2658
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0137
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0023 0.0015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0135 0.0148
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0135 0.0148
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0021 0.0029
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0377 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.072 0.1666
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.017 0.019
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0085 0.072 0.0713
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Toxoplasma gondii thioredoxin reductase 0.0045 0.0315 0.6
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0026 0.0021
Echinococcus granulosus dna polymerase eta 0.0019 0.0062 0.0054
Loa Loa (eye worm) thioredoxin reductase 0.0045 0.0315 0.0719
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0135 0.0127
Onchocerca volvulus 0.0026 0.0135 0.0456
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Schistosoma mansoni hypothetical protein 0.0873 0.8535 1
Echinococcus multilocularis lamin dm0 0.006 0.0464 0.0456
Brugia malayi AKH receptor 0.0026 0.0135 0.0296
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0135 0.0127
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0062 0.0298
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0085 0.072 0.0835
Echinococcus granulosus thioredoxin glutathione reductase 0.0045 0.0321 0.0313
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.0135 0.0296
Mycobacterium tuberculosis Conserved protein 0.0035 0.0217 0.1047
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0026 0.0348
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0113 0.0996 1
Brugia malayi Serotonin receptor 0.0026 0.0135 0.0296
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0135 0.0127
Brugia malayi hypothetical protein 0.0026 0.0135 0.0296
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0014 0.0008 0.0039
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0062 0.0137
Echinococcus multilocularis dna polymerase eta 0.0019 0.0062 0.0054
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0026 0.0024
Treponema pallidum NADH oxidase 0.0015 0.0026 0.5
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0085 0.072 0.1666
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0021 0.0029
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0217 0.5525
Brugia malayi Calcium binding EGF domain containing protein 0.0085 0.072 0.1666
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0015 0.0021 0.009
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.019 0.176 0.4098
Echinococcus granulosus g protein coupled receptor 0.0026 0.0135 0.0127
Brugia malayi hypothetical protein 0.0026 0.0135 0.0296
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0021 0.0029
Brugia malayi Thioredoxin reductase 0.0045 0.0315 0.0719
Echinococcus granulosus low density lipoprotein receptor protein 0.0085 0.072 0.0713
Onchocerca volvulus 0.0085 0.072 0.2798
Brugia malayi MH2 domain containing protein 0.0238 0.2233 0.5204
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0526 0.0519
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0139 0.1254 0.1246
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0021 0.0029
Onchocerca volvulus 0.0085 0.072 0.2798
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0217 0.0909
Loa Loa (eye worm) hypothetical protein 0.0023 0.0103 0.0223
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0026 0.0018
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0023 0.0017
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0085 0.072 0.0713
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.0135 0.0127
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0279 0.0635
Brugia malayi latrophilin 2 splice variant baaae 0.0142 0.1285 0.2986
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.017 0.0162
Echinococcus multilocularis thioredoxin glutathione reductase 0.0045 0.0321 0.0313
Brugia malayi MH2 domain containing protein 0.0016 0.0033 0.0059
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0135 0.0127
Brugia malayi G protein-coupled receptor 0.0026 0.0135 0.0296
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0454 0.3213
Schistosoma mansoni hypothetical protein 0.0023 0.0099 0.0106
Loa Loa (eye worm) hypothetical protein 0.0085 0.072 0.1666
Brugia malayi enteropeptidase precursor 0.0085 0.072 0.1666
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0377 0.2658
Onchocerca volvulus 0.0026 0.0135 0.0456
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0085 0.072 0.0713
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0158 0.015
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0135 0.0127
Loa Loa (eye worm) hypothetical protein 0.0085 0.072 0.1666
Echinococcus granulosus intermediate filament protein 0.006 0.0464 0.0456
Mycobacterium tuberculosis Probable oxidoreductase 0.0113 0.0996 0.4794
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.0135 0.0127
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0217 0.0246
Brugia malayi jmjC domain containing protein 0.0015 0.0023 0.0034
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0113 0.0996 0.4794
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.0135 0.0148
Schistosoma mansoni biogenic amine receptor 0.0026 0.0135 0.0148
Schistosoma mansoni neuropeptide receptor 0.0026 0.0135 0.0148
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0135 0.0127
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0042 0.0034
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0103 0.0095
Brugia malayi CXXC zinc finger family protein 0.0034 0.0209 0.0469
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0102 0.0883 0.4251
Echinococcus granulosus smad 0.0016 0.0033 0.0025
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.0135 0.0148
Loa Loa (eye worm) hypothetical protein 0.0066 0.0526 0.1212
Brugia malayi beta-lactamase 0.0035 0.0217 0.049
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0085 0.072 0.1666
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Schistosoma mansoni amine GPCR 0.0026 0.0135 0.0148
Echinococcus multilocularis serotonin receptor 0.0026 0.0135 0.0127
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0014 0.0008 0.0039
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.4284 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0014 0.0008 0.0039
Loa Loa (eye worm) hypothetical protein 0.0228 0.2139 0.4983
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0103 0.2321
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0217 0.1047
Schistosoma mansoni biogenic amine receptor 0.0026 0.0135 0.0148
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0062 0.0191
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0377 0.0863
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0377 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0021 0.0099
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0021 0.0029
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0026 0.0128
Brugia malayi hypothetical protein 0.0026 0.0135 0.0296
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0021 0.0029
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0023 0.0034
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.0135 0.0127
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0135 0.0148
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0051 0.0377 0.2658
Trypanosoma brucei cytochrome P450, putative 0.0014 0.0008 0.0012
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0015 0.0021 0.009
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0021 0.0029
Onchocerca volvulus 0.0023 0.0103 0.0331
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0135 0.0127
Trypanosoma brucei trypanothione reductase 0.0045 0.0315 0.0729
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0137
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0062 0.0063
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0026 0.0135 0.0148
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0014 0.0008 0.0039
Mycobacterium ulcerans acetyl-CoA synthetase 0.0015 0.0021 0.009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0023 0.0015
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0135 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0137
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0455 0.0524
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.0135 0.0127
Brugia malayi Dopamine receptor protein 2 0.0026 0.0135 0.0296
Echinococcus granulosus lamin dm0 0.006 0.0464 0.0456
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0038 0.025 1
Onchocerca volvulus 0.0085 0.072 0.2798
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0033 0.0025
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.025 0.1202
Schistosoma mansoni amine GPCR 0.0026 0.0135 0.0148
Loa Loa (eye worm) hypothetical protein 0.0085 0.072 0.1666
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0377 1
Schistosoma mansoni amine GPCR 0.0026 0.0135 0.0148
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0021 0.0029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0026 0.0042
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0135 0.0127
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0152 0.0144
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0023 0.0017
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0026 0.0135 0.0127
Trichomonas vaginalis esterase, putative 0.0035 0.0217 0.0909
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0062 0.0137
Loa Loa (eye worm) hypothetical protein 0.0145 0.1307 0.3038
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0015 0.0021 0.009
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0062 0.1159
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0023 0.0034
Onchocerca volvulus 0.0047 0.0335 0.1256
Onchocerca volvulus Huntingtin homolog 0.0145 0.1307 0.5145
Leishmania major hypothetical protein, conserved 0.0035 0.0217 0.049
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0217 0.049
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0217 0.049
Leishmania major DNA polymerase eta, putative 0.0019 0.0062 0.0126
Loa Loa (eye worm) hypothetical protein 0.0038 0.025 0.0565
Brugia malayi neuropeptide F receptor 0.0026 0.0135 0.0296
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0217 0.0501
Echinococcus granulosus Smad4 0.0016 0.0033 0.0025
Echinococcus granulosus g protein coupled receptor 0.0026 0.0135 0.0127
Onchocerca volvulus 0.0051 0.0377 0.1426
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0103 0.2321
Brugia malayi hypothetical protein 0.0026 0.0135 0.0296
Echinococcus granulosus allatostatin A receptor 0.0026 0.0135 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0137
Plasmodium falciparum thioredoxin reductase 0.0015 0.0026 0.0148
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0267 0.2521 0.5877
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0021 0.0015
Schistosoma mansoni hypothetical protein 0.0142 0.1285 0.1497
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0596 0.069
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0217 0.0246
Mycobacterium tuberculosis Conserved protein 0.0035 0.0217 0.1047
Echinococcus granulosus serotonin receptor 0.0026 0.0135 0.0127
Schistosoma mansoni vesicular acetylcholine transporter 0.0267 0.2521 0.2947
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.0135 0.0296
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.0135 0.0148
Toxoplasma gondii hypothetical protein 0.0047 0.0339 0.6466
Brugia malayi Calcitonin receptor-like protein seb-1 0.0208 0.1939 0.4515
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0135 0.0148
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0026 0.0148
Loa Loa (eye worm) hypothetical protein 0.0085 0.072 0.1666
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.025 0.6429
Brugia malayi G-protein coupled receptor 0.0026 0.0135 0.0296
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0217 0.021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0014 0.0008 0.0039
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0014 0.0008 0.0039
Loa Loa (eye worm) hypothetical protein 0.0035 0.0217 0.049
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.0135 0.0148
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0021 0.009
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0135 0.0127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.176 0.1753
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.0135 0.0127
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.017 0.019
Toxoplasma gondii ABC1 family protein 0.0035 0.0217 0.4088
Echinococcus multilocularis geminin 0.0873 0.8535 0.8534
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0021 0.0099
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0085 0.072 0.1666
Echinococcus multilocularis serotonin receptor 0.0026 0.0135 0.0127
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.0135 0.0127
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0062 0.0388
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0062 0.0054
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0217 0.1508
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.176 0.1753
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0033 0.0025
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0368 0.0843
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0135 0.0127
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0085 0.072 0.1666
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0135 0.0148
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0033 0.0025
Brugia malayi hypothetical protein 0.0026 0.0135 0.0296
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0021 0.0013
Brugia malayi hypothetical protein 0.0026 0.0135 0.0296
Schistosoma mansoni cpg binding protein 0.0036 0.0228 0.0258
Echinococcus multilocularis orexin receptor type 2 0.0026 0.0135 0.0127
Loa Loa (eye worm) hypothetical protein 0.0038 0.025 0.0565
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0015 0.0021 0.009
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1905 0.4438
Schistosoma mansoni hypothetical protein 0.0026 0.0135 0.0148
Schistosoma mansoni smad1 5 8 and 0.0016 0.0033 0.003
Loa Loa (eye worm) Smad1 0.0016 0.0033 0.0059
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0217 0.1047
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0085 0.072 0.2798
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0135 0.0127
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0026 0.0042
Echinococcus granulosus neuropeptide receptor A26 0.1021 1 1
Echinococcus multilocularis RUN 0.0023 0.0103 0.0095
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0026 0.0148
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0051 0.0377 0.2658
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.4284 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0377 0.0863
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0062 0.0126
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0021 0.0029
Plasmodium vivax JmjC domain containing protein 0.0015 0.0023 0.0058
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0062 0.0126
Echinococcus granulosus neuropeptide receptor 0.0026 0.0135 0.0127
Schistosoma mansoni hypothetical protein 0.0066 0.0526 0.0608
Echinococcus multilocularis GPCR, family 2 0.0066 0.0526 0.0519
Brugia malayi basement membrane proteoglycan precursor 0.0085 0.072 0.1666
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0139 0.1254 0.1246
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0454 0.3213
Echinococcus granulosus g protein coupled receptor 0.0026 0.0135 0.0127
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0021 0.0245
Schistosoma mansoni lipoxygenase 0.0097 0.0838 0.0973
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.2767 0.6457
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0026 0.0042
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0085 0.072 0.1666
Schistosoma mansoni hypothetical protein 0.0026 0.0135 0.0148
Echinococcus multilocularis musashi 0.006 0.0464 0.0456
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0015 0.0026 0.0125
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0135 0.0148
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0026 0.0053
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0023 0.0015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0135 0.0127
Brugia malayi hypothetical protein 0.0026 0.0135 0.0296
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0135 0.0127
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0103 0.0223
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0209 0.0469
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0085 0.072 0.1666
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0026 0.0042
Onchocerca volvulus Arrow homolog 0.0085 0.072 0.2798
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.0135 0.0127
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0102 0.0883 0.8858
Loa Loa (eye worm) glutathione reductase 0.0045 0.0315 0.0719
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0045 0.0315 0.1518
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0454 0.0447
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Onchocerca volvulus 0.0026 0.0135 0.0456
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0526 0.0519
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0026 0.0018
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0217 0.212
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0135 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0137
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0135 0.0148
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.0135 0.0296
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0062 0.0054
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0021 0.0029
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0217 0.0909
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0021 0.0029
Brugia malayi hypothetical protein 0.0026 0.0135 0.0296
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0026 0.0042
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0051 0.0377 0.3738
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0135 0.0127
Loa Loa (eye worm) hypothetical protein 0.003 0.017 0.0379
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0217 0.021
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0014 0.0008 0.0039
Brugia malayi hypothetical protein 0.0026 0.0135 0.0296
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0526 0.0519
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0026 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.176 0.2055
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0023 0.0015
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0279 0.0635
Loa Loa (eye worm) hypothetical protein 0.0085 0.072 0.1666
Onchocerca volvulus 0.0026 0.0135 0.0456
Loa Loa (eye worm) hypothetical protein 0.0035 0.0217 0.049
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0014 0.0008 0.0039
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0023 0.0017
Schistosoma mansoni amine GPCR 0.0026 0.0135 0.0148
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0135 0.0148
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0377 0.0863
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0137
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0021 0.0099
Schistosoma mansoni hypothetical protein 0.0085 0.072 0.0835
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0454 0.0523
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0026 0.0135 0.0127
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0021 0.0099
Loa Loa (eye worm) hypothetical protein 0.0085 0.072 0.1666
Mycobacterium tuberculosis Conserved protein 0.0035 0.0217 0.1047
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0135 0.0148
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0135 0.0127
Schistosoma mansoni opsin-like receptor 0.0026 0.0135 0.0148
Onchocerca volvulus 0.0026 0.0135 0.0456
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0135 0.0148
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0085 0.072 0.0713
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0021 0.0041
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0135 0.0127
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.006 0.0464 0.1067
Plasmodium vivax glutathione reductase, putative 0.0045 0.0315 0.8274
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Brugia malayi Serotonin receptor 0.0026 0.0135 0.0296
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0279 0.0635
Brugia malayi Pre-SET motif family protein 0.003 0.017 0.0379
Echinococcus granulosus phd:f box containing protein 0.0015 0.0023 0.0015
Loa Loa (eye worm) hypothetical protein 0.0142 0.1285 0.2986
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0033 0.003
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0062 0.0126
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0014 0.0008 0.0039
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0051 0.0377 0.1816
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0099 0.0091
Echinococcus multilocularis vesicular acetylcholine transporter 0.0267 0.2521 0.2515
Mycobacterium leprae Probable lipase LipE 0.0035 0.0217 0.212
Onchocerca volvulus 0.0026 0.0135 0.0456
Loa Loa (eye worm) hypothetical protein 0.0051 0.0377 0.0863
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0085 0.072 0.1666
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0023 0.0286
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0454 0.1044
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0021 0.009
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.0135 0.0127
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0051 0.0377 0.3738
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0374 0.0855
Echinococcus granulosus basement membrane specific heparan sulfate 0.0085 0.072 0.0713
Loa Loa (eye worm) hypothetical protein 0.0445 0.4284 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0062 0.0126
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0217 0.1047
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0021 0.009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0062 0.0126
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0029
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0377 0.0863
Trypanosoma brucei unspecified product 0.0019 0.0062 0.0137
Echinococcus granulosus neuropeptide receptor 0.0026 0.0135 0.0127
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0085 0.072 0.0835
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.0135 0.0296
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0137
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0135 0.0127
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.0135 0.0127
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.017 0.0162
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0135 0.0127
Echinococcus granulosus low density lipoprotein receptor ldl 0.0085 0.072 0.0713
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0189 0.0424
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Onchocerca volvulus 0.0035 0.0217 0.0787
Echinococcus granulosus fmrfamide receptor 0.0026 0.0135 0.0127
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1242 0.2887
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.2077 1
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0135 0.0127
Schistosoma mansoni hypothetical protein 0.0873 0.8535 1
Schistosoma mansoni rab6-interacting 0.0023 0.0103 0.0112
Loa Loa (eye worm) hypothetical protein 0.0023 0.0103 0.0223
Onchocerca volvulus Neuropeptide F receptor homolog 0.0026 0.0135 0.0456
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.017 0.0162
Onchocerca volvulus 0.006 0.0464 0.1774
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0014 0.0008 0.0039
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.0135 0.0127
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0021 0.0099
Brugia malayi Melatonin receptor type 1A 0.0026 0.0135 0.0296
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0436 0.0428
Brugia malayi follicle stimulating hormone receptor 0.0026 0.0135 0.0296
Onchocerca volvulus 0.002 0.0066 0.0181
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0377 0.72
Mycobacterium ulcerans hypothetical protein 0.0154 0.1397 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.072 0.1666
Schistosoma mansoni hypothetical protein 0.0066 0.0526 0.0608
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.017 0.3168
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0436 0.0502
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0021 0.0099
Brugia malayi ORL1-like opioid receptor 0.0026 0.0135 0.0296
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0085 0.072 0.1666
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0135 0.0127
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0085 0.072 0.0713
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0135 0.0127
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.052 1
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0135 0.0127
Mycobacterium tuberculosis Probable reductase 0.0102 0.0883 0.4251
Brugia malayi sulfakinin receptor protein 0.0026 0.0135 0.0296
Mycobacterium ulcerans beta-lactamase 0.0035 0.0217 0.1508
Brugia malayi jmjC domain containing protein 0.0015 0.0023 0.0034
Schistosoma mansoni hypothetical protein 0.0066 0.0526 0.0608
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0026 0.0148
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Onchocerca volvulus 0.0035 0.0217 0.0787
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Schistosoma mansoni hypothetical protein 0.0026 0.0135 0.0148
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0189 0.0424
Brugia malayi jmjC domain containing protein 0.0015 0.0023 0.0034
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0217 0.1047
Entamoeba histolytica acyl-coA synthetase, putative 0.0051 0.0377 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0454 0.0523
Onchocerca volvulus 0.0026 0.0135 0.0456
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.0135 0.0127
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0023 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0026 0.0042
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0135 0.0127
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0135 0.0148
Loa Loa (eye worm) hypothetical protein 0.0208 0.1939 0.4515
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0085 0.072 0.0713
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0014 0.0008 0.0039
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0026 0.0042
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0208 0.1939 0.4515
Brugia malayi Doublecortin family protein 0.0023 0.0103 0.0223
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0014 0.0008 0.0039
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0029
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0023 0.0017
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0062 0.0388
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.0135 0.0127
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0455 0.0448
Brugia malayi vesicular acetylcholine transporter unc-17 0.0267 0.2521 0.5877
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0135 0.0127
Echinococcus granulosus RUN 0.0023 0.0103 0.0095
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0026 0.0042
Plasmodium vivax SET domain protein, putative 0.003 0.017 0.4202
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0267 0.2521 1
Brugia malayi Pre-SET motif family protein 0.0205 0.1905 0.4438
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0026 0.0128
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0217 0.1047
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0023 0.0034
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0051 0.0377 0.2658
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.176 0.1753
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0021 0.0029
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.1242 0.2895
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0023 0.0015
Brugia malayi glutathione reductase 0.0045 0.0315 0.0719
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0229 0.1103
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0135 0.0127
Echinococcus multilocularis neuropeptide s receptor 0.1021 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0062 0.0126
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0377 0.0863
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0026 0.0053
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0085 0.072 0.0835
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.0135 0.0127
Schistosoma mansoni hypothetical protein 0.0047 0.0335 0.0383
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0217 0.1508
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0217 0.1047
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0023 0.0015
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0023 0.0017
Onchocerca volvulus 0.0034 0.0209 0.0752
Plasmodium vivax thioredoxin reductase, putative 0.0045 0.0315 0.8274
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0135 0.0127
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0026 0.0042
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0062 0.0054
Echinococcus granulosus GPCR family 2 0.0066 0.0526 0.0519
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0351
Onchocerca volvulus 0.0026 0.0135 0.0456
Schistosoma mansoni neuropeptide receptor 0.0026 0.0135 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0137
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0085 0.072 0.1666
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0051 0.0377 0.2658
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0217 0.049
Mycobacterium ulcerans lipase LipD 0.0035 0.0217 0.1508
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0217 0.0909
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0085 0.072 0.0713
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0455 0.0524
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.1242 0.2887
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0085 0.072 0.1666
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0135 0.0127
Loa Loa (eye worm) hypothetical protein 0.0035 0.0217 0.049
Brugia malayi hypothetical protein 0.0023 0.0103 0.0223
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0526 0.1212
Plasmodium falciparum glutathione reductase 0.0015 0.0026 0.0148
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0015 0.0021 0.0127
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0015 0.0021 0.009
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0023 0.0286
Loa Loa (eye worm) hypothetical protein 0.0026 0.0135 0.0296
Brugia malayi G-protein coupled receptor 0.0026 0.0135 0.0296
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0135 0.0127
Onchocerca volvulus 0.006 0.0464 0.1774
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0014 0.0008 0.0039
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0135 0.0127
Schistosoma mansoni neuropeptide receptor 0.0026 0.0135 0.0148
Schistosoma mansoni DNA polymerase eta 0.0019 0.0062 0.0063
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0034
Brugia malayi hypothetical protein 0.0023 0.0103 0.0223
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0229 0.1103
Schistosoma mansoni opsin-like receptor 0.0026 0.0135 0.0148
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.019 0.176 0.4098
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0014 0.0008 0.0039
Brugia malayi jmjC domain containing protein 0.0015 0.0023 0.0034
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0026 0.0128
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.2767 0.6452
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0034
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0436 0.0428
Echinococcus multilocularis low density lipoprotein receptor protein 0.0085 0.072 0.0713
Schistosoma mansoni histamine h1 receptor 0.0026 0.0135 0.0148
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0102 0.0883 0.4251
Brugia malayi Intermediate filament tail domain containing protein 0.006 0.0464 0.1067
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0377 0.0863
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0135 0.0296
Onchocerca volvulus 0.0035 0.0217 0.0787

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 2310 nM Displacement of (-)-[3H]vesamicol from human VAChT expressed in rat PC12 cell membrane after 20 hrs ChEMBL. 23802889
Ki (binding) = 9240 nM Displacement of (+)- [3H]pentazocine from sigma 1 receptor expressed in guinea pig brain membrane homogenates by scintillation counting analysis ChEMBL. 23802889

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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