Detailed information for compound 17728

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 572.608 | Formula: C31H32N4O7
  • H donors: 3 H acceptors: 6 LogP: 4.34 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: N#C/C(=C(\[C@H](C(=O)C(Cc1ccc(cc1)OCc1ccccc1)N)NC(=O)OC(C)(C)C)/O)/c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C31H32N4O7/c1-31(2,3)42-30(38)34-27(28(36)25(18-32)22-11-13-23(14-12-22)35(39)40)29(37)26(33)17-20-9-15-24(16-10-20)41-19-21-7-5-4-6-8-21/h4-16,26-27,36H,17,19,33H2,1-3H3,(H,34,38)/b28-25-/t26?,27-/m1/s1
  • InChiKey: WCENIQUWWYMLBZ-RGFSYDALSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei variant surface glycoprotein (VSG), putative Human immunodeficiency virus type 1 protease   99 aa 80 aa 27.5 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Mycobacterium leprae Hypothetical protein Human immunodeficiency virus type 1 protease   99 aa 86 aa 27.9 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Echinococcus multilocularis Chromobox protein 3 Human immunodeficiency virus type 1 protease   99 aa 95 aa 28.4 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Giardia lamblia DNA-directed RNA polymerase subunit D Human immunodeficiency virus type 1 protease   99 aa 90 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0077 0.0176
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.006 0.0139
Loa Loa (eye worm) cytochrome P450 family protein 0.007 0.0159 0.0634
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0127 0.18
Echinococcus granulosus neutral amino acid transporter A 0.0122 0.0307 0.0303
Loa Loa (eye worm) hypothetical protein 0.0065 0.0144 0.0573
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0029 0.0041 0.0158
Leishmania major ATP-dependent phosphofructokinase 0.0127 0.0321 0.4349
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.0705 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0127 0.0322 0.4563
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0116 0.0112
Onchocerca volvulus 0.0016 0.0004 0.0009
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0065 0.0144 0.014
Echinococcus granulosus bloom syndrome protein 0.0042 0.0079 0.0075
Chlamydia trachomatis endonuclease IV 0.0081 0.0189 0.6099
Echinococcus multilocularis excitatory amino acid transporter 3 0.0122 0.0307 0.0303
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0021
Brugia malayi Pre-SET motif family protein 0.0881 0.2485 1
Brugia malayi Cache domain containing protein 0.0705 0.1979 0.7963
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.0321 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.006 0.0056
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0157 0.0153
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0322 0.0741
Schistosoma mansoni polycystin 1-related 0.002 0.0014 0.0032
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0081 0.0262
Brugia malayi von Willebrand factor type A domain containing protein 0.0065 0.0144 0.0573
Loa Loa (eye worm) hypothetical protein 0.0065 0.0144 0.0573
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.0705 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0056 0.1625
Onchocerca volvulus 0.0065 0.0144 0.0502
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0081 0.1873
Schistosoma mansoni lamin 0.0116 0.0289 0.0667
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0023 0.0023 0.0087
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0016 0.0004 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0077 0.0246
Echinococcus granulosus neutral amino acid transporter A 0.0122 0.0307 0.0303
Schistosoma mansoni aldehyde dehydrogenase 0.026 0.0705 0.1623
Brugia malayi intermediate filament protein 0.0116 0.0289 0.1158
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0066 0.0846
Loa Loa (eye worm) phosphofructokinase 0.0127 0.0321 0.1286
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0056 0.0172
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0065 0.0144 0.7573
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.006 0.0207
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0006 0.0002
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0066 0.1155
Toxoplasma gondii kringle domain-containing protein 0.0024 0.0026 0.0368
Echinococcus multilocularis voltage dependent calcium channel subunit 0.35 1 1
Echinococcus multilocularis tissue type plasminogen activator 0.0024 0.0026 0.0022
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0006 0.0014
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0257 0.0695 0.0691
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0042 0.0077 0.0072
Onchocerca volvulus 0.002 0.0014 0.0043
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0056 0.0791
Echinococcus granulosus tumor protein p63 0.0352 0.0967 0.0963
Echinococcus granulosus excitatory amino acid transporter 3 0.0122 0.0307 0.0303
Schistosoma mansoni laminin gamma-3 chain 0.0049 0.0097 0.0223
Treponema pallidum glutamate transporter 0.0054 0.0112 0.0181
Echinococcus granulosus regulator of G protein signaling 3 0.0042 0.0077 0.0072
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0066 0.0259
Loa Loa (eye worm) hypothetical protein 0.0107 0.0266 0.1063
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0073 0.0069
Brugia malayi von Willebrand factor type A domain containing protein 0.0065 0.0144 0.0573
Toxoplasma gondii microneme protein MIC17A 0.0015 0.0002 0.0024
Brugia malayi Receptor family ligand binding region containing protein 0.0023 0.0023 0.0087
Loa Loa (eye worm) hypothetical protein 0.0065 0.0144 0.0573
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.006 0.0237
Brugia malayi Intermediate filament tail domain containing protein 0.0116 0.0289 0.1158
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0056 0.1704
Entamoeba histolytica hypothetical protein 0.0065 0.0144 0.4484
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0049 0.0097 0.0383
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0002 0.0024
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0062 0.0135 0.0538
Brugia malayi laminin-like protein K08C7.3 precursor 0.0049 0.0097 0.0383
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0002 0.0024
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0033 0.155
Onchocerca volvulus 0.1003 0.2834 1
Loa Loa (eye worm) CUTiclin family member 0.0065 0.0144 0.0573
Trichomonas vaginalis rotamase, putative 0.0033 0.0051 0.0156
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0017
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0006 0.0002
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.0755 0.1738
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0042 0.0077 0.0301
Toxoplasma gondii hypothetical protein 0.0015 0.0002 0.0024
Echinococcus multilocularis cpg binding protein 0.003 0.0045 0.004
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0015 0.0002 0.0024
Onchocerca volvulus 0.0024 0.0026 0.0085
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0041 0.058
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0006 0.0017
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0033 0.0902
Brugia malayi Kringle domain containing protein 0.0024 0.0026 0.0097
Brugia malayi Zona pellucida-like domain containing protein 0.0065 0.0144 0.0573
Schistosoma mansoni lipoxygenase 0.002 0.0014 0.0032
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0029 0.0041 0.0037
Loa Loa (eye worm) hypothetical protein 0.0065 0.0144 0.0573
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0029 0.0041 0.199
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0081 0.0077
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0066 0.0209
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0014 0.001
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0066 0.0103
Brugia malayi PXA domain containing protein 0.0042 0.0077 0.0301
Brugia malayi nuclear receptor RXR 0.0017 0.0006 0.0017
Echinococcus multilocularis regulator of G protein signaling 3 0.0042 0.0077 0.0072
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0049 0.0097 0.0223
Loa Loa (eye worm) hypothetical protein 0.0049 0.0097 0.0383
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0066 0.1951
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0004 0.0059
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0127 0.0321 1
Echinococcus multilocularis neutral amino acid transporter A 0.0122 0.0307 0.0303
Loa Loa (eye worm) 6-phosphofructokinase 0.0127 0.0321 0.1286
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0116 0.0289 0.1158
Loa Loa (eye worm) hypothetical protein 0.0065 0.0144 0.0573
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0006 0.0002
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0056 0.0172
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0056 0.0172
Echinococcus granulosus survival motor neuron protein 1 0.0276 0.0749 0.0745
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.006 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0077 0.0246
Toxoplasma gondii aldehyde dehydrogenase 0.026 0.0705 1
Brugia malayi Protein kinase domain containing protein 0.0024 0.0026 0.0097
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0066 0.2057
Schistosoma mansoni zinc finger protein 0.0017 0.0006 0.0014
Onchocerca volvulus 0.0016 0.0004 0.0009
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0042 0.0077 0.0176
Schistosoma mansoni hypothetical protein 0.002 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.005
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0029 0.0041 0.0037
Brugia malayi 6-phosphofructokinase 0.0127 0.0321 0.1286
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0066 0.0062
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0054 0.0112 0.0259
Echinococcus granulosus pikachurin 0.0049 0.0097 0.0093
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0006 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0127 0.0322 0.0741
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.0056 0.0086
Loa Loa (eye worm) hypothetical protein 0.0036 0.006 0.0237
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0232 0.0624 0.062
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0077 0.0176
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0006 0.0014
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.2104 0.5994 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.006 0.0237
Brugia malayi conserved hypotetical protein 0.0017 0.0006 0.0017
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0006 0.0002
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.006 0.0237
Loa Loa (eye worm) hypothetical protein 0.0029 0.0041 0.0158
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0081 0.0077
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0017
Brugia malayi von Willebrand factor type A domain containing protein 0.0065 0.0144 0.0573
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0077 0.0176
Loa Loa (eye worm) hypothetical protein 0.0065 0.0144 0.0573
Echinococcus multilocularis expressed protein 0.0808 0.2277 0.2273
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0065 0.0144 0.2043
Echinococcus multilocularis neutral amino acid transporter A 0.0122 0.0307 0.0303
Loa Loa (eye worm) hypothetical protein 0.0705 0.1979 0.7963
Brugia malayi EGF-like domain containing protein 0.0049 0.0097 0.0383
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0056 0.1735
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.006 0.0237
Echinococcus granulosus expressed protein 0.0808 0.2277 0.2273
Schistosoma mansoni cpg binding protein 0.003 0.0045 0.0103
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0002 0.0024
Schistosoma mansoni hypothetical protein 0.0257 0.0695 0.16
Loa Loa (eye worm) hypothetical protein 0.0054 0.0112 0.0442
Echinococcus granulosus lamin 0.0116 0.0289 0.0285
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0024 0.0026 0.0685
Echinococcus multilocularis neutral amino acid transporter A 0.0122 0.0307 0.0303
Trichomonas vaginalis DNA helicase recq1, putative 0.0042 0.0079 0.0254
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0012 0.0027
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0081 0.0077
Toxoplasma gondii subtilisin SUB12 0.0015 0.0002 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0077 0.0246
Echinococcus granulosus Regulator of G protein signaling 20 0.0042 0.0077 0.0072
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0002 0.0024
Schistosoma mansoni nuclear receptor 0.0017 0.0006 0.0014
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0004 0.001
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.077 0.2166 0.4989
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0051 0.0724
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0049 0.0336
Loa Loa (eye worm) hypothetical protein 0.0065 0.0144 0.0573
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0029 0.0041 0.0037
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0006 0.0015
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0081 0.0262
Brugia malayi metabotropic glutamate receptor type 2 0.0044 0.0083 0.0325
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0127 0.0321 0.4502
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0004 0.001
Schistosoma mansoni thyroid hormone receptor 0.0293 0.0798 0.1837
Brugia malayi Metabotropic glutamate receptor precursor. 0.0089 0.0214 0.0855
Onchocerca volvulus 0.0017 0.0006 0.0015
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0006 0.0017
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0041 0.0158
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0051 0.0632
Entamoeba histolytica hypothetical protein 0.0037 0.0065 0.2023
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0232 0.0624 0.2507
Schistosoma mansoni axis inhibition protein axin 0.0042 0.0077 0.0176
Treponema pallidum glutamate/aspartate transporter 0.0054 0.0112 0.0181
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0067
Loa Loa (eye worm) hypothetical protein 0.0276 0.0749 0.3007
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.006 0.0056
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0004 0.001
Mycobacterium ulcerans epimerase 0.0021 0.0018 0.0162
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.006 0.0056
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0006 0.0002
Brugia malayi von Willebrand Factor 0.0065 0.0144 0.0573
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0041
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0107 0.0266 0.0612
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0004 0.001
Schistosoma mansoni hypothetical protein 0.0065 0.0144 0.0332
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0056 0.0172
Entamoeba histolytica hypothetical protein 0.0042 0.0077 0.2385
Brugia malayi Zona pellucida-like domain containing protein 0.0065 0.0144 0.0573
Echinococcus granulosus transcription factor Dp 1 0.004 0.0073 0.0069
Loa Loa (eye worm) hypothetical protein 0.0081 0.0189 0.0753
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.006 0.0056
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.006 0.0056
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.0321 1
Onchocerca volvulus 0.0116 0.0289 0.1015
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0004 0.001
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1592 0.4525 0.4523
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0065 0.0144 0.0573
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.006 0.0237
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0056 0.1625
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1527 0.4338 0.9994
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0018 0.0162
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0006 0.0002
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.006 0.0207
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0017
Brugia malayi follicle stimulating hormone receptor 0.0275 0.0746 0.2997
Brugia malayi nuclear hormone receptor 0.0036 0.006 0.0237
Toxoplasma gondii hypothetical protein 0.0015 0.0002 0.0024
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0056 0.0172
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0012 0.0027
Loa Loa (eye worm) hypothetical protein 0.0036 0.006 0.0237
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0017 0.0007 0.0019
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0321 0.1111
Entamoeba histolytica hypothetical protein 0.0042 0.0077 0.2385
Chlamydia trachomatis glutamate symporter 0.0122 0.0307 1
Brugia malayi hypothetical protein 0.0042 0.0077 0.0301
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0122 0.0307 0.0303
Loa Loa (eye worm) hypothetical protein 0.0043 0.0081 0.032
Schistosoma mansoni ap endonuclease 0.0038 0.0066 0.0152
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0077 0.0176
Echinococcus multilocularis expressed protein 0.0033 0.0053 0.0049
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0127 0.0321 0.0529
Loa Loa (eye worm) DR-78 0.0017 0.0006 0.0017
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0014 0.001
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0157 0.1927
Echinococcus multilocularis thyroid hormone receptor alpha 0.0293 0.0798 0.0794
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.006 0.0237
Brugia malayi 6-phosphofructokinase 0.0127 0.0321 0.1286
Schistosoma mansoni metabotropic glutamate receptor 0.0044 0.0083 0.019
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.113 0.1127
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0122 0.0306 0.0302
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0077 0.0246
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0012 0.0008
Schistosoma mansoni z-protein (S1r protein) 0.0042 0.0077 0.0176
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0014 0.001
Giardia lamblia Sgs1 DNA helicase, putative 0.0029 0.0041 0.4566
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.006 0.0237
Echinococcus granulosus regulator of G protein signaling 7 0.0042 0.0077 0.0072
Brugia malayi Immunoglobulin I-set domain containing protein 0.0065 0.0144 0.0573
Schistosoma mansoni hypothetical protein 0.0037 0.0065 0.015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0077 0.0176
Schistosoma mansoni rab6-interacting 0.002 0.0014 0.0032
Brugia malayi nuclear receptor NHR-88 0.0036 0.006 0.0237
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0127 0.0321 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.006 0.0237
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.4341 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0112 0.0442
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.006 0.0056
Schistosoma mansoni cpg binding protein 0.003 0.0045 0.0103
Loa Loa (eye worm) norepinephrine transporter 0.0016 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0041 0.058
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0033 0.155
Toxoplasma gondii microneme protein MIC4 0.0015 0.0002 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0053 0.0163
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0107 0.0266 0.0612
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0006 0.0017
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.081 0.2283 0.228
Loa Loa (eye worm) hypothetical protein 0.0036 0.006 0.0237
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0041 0.0158
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0157 0.0624
Mycobacterium ulcerans hypothetical protein 0.0021 0.0018 0.0162
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0322 0.0741
Loa Loa (eye worm) hypothetical protein 0.0107 0.0266 0.1063
Echinococcus multilocularis geminin 0.0169 0.0443 0.0439
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0081 0.0189 0.0753
Loa Loa (eye worm) hypothetical protein 0.0042 0.0077 0.0301
Entamoeba histolytica recQ family helicase, putative 0.0032 0.0049 0.1517
Echinococcus granulosus axis inhibition protein axin 0.0042 0.0077 0.0072
Loa Loa (eye worm) hypothetical protein 0.0036 0.006 0.0237
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0006 0.0017
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0029 0.0041 0.0037
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0049 0.0553
Toxoplasma gondii exonuclease III APE 0.0038 0.0066 0.0937
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0157 0.0361
Echinococcus multilocularis regulator of G protein signaling 7 0.0042 0.0077 0.0072
Schistosoma mansoni serine-rich repeat protein 0.0822 0.2316 0.5336
Echinococcus multilocularis pikachurin 0.0049 0.0097 0.0093
Brugia malayi A-kinase anchor protein 10, precursor 0.0042 0.0077 0.0301
Schistosoma mansoni 6-phosphofructokinase 0.0127 0.0321 0.074
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0127 0.0321 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0042 0.0077 0.0072
Loa Loa (eye worm) hypothetical protein 0.0127 0.0322 0.1288
Echinococcus multilocularis tumor protein p63 0.0352 0.0967 0.0963
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.026 0.0705 1
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0321 0.1111
Loa Loa (eye worm) intermediate filament protein 0.0116 0.0289 0.1158
Onchocerca volvulus 0.0065 0.0144 0.0502
Schistosoma mansoni axis inhibition protein axin 0.0042 0.0077 0.0176
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0042 0.0077 0.0246
Echinococcus multilocularis excitatory amino acid transporter 2 0.0122 0.0307 0.0303
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0054 0.0112 0.0259
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0081 0.2529
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0006 0.0017
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0321 0.1111
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0102 0.0249 0.0574
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0157 0.488
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.006 0.0056
Onchocerca volvulus 0.0065 0.0144 0.0502
Loa Loa (eye worm) TK/ROR protein kinase 0.0024 0.0026 0.0097
Mycobacterium ulcerans endonuclease IV 0.0081 0.0189 0.2605
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0081 0.0187
Onchocerca volvulus 0.0065 0.0144 0.0502
Loa Loa (eye worm) CUTiclin-Like family member 0.0065 0.0144 0.0573
Schistosoma mansoni nuclear receptor 0.0017 0.0006 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0065 0.0144 0.4405
Schistosoma mansoni cpg binding protein 0.0029 0.004 0.0092
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0122 0.0307 0.0303
Loa Loa (eye worm) RGS-3 protein 0.0042 0.0077 0.0301
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Echinococcus multilocularis musashi 0.0116 0.0289 0.0285
Loa Loa (eye worm) hypothetical protein 0.0042 0.0077 0.0301
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0006 0.0015
Toxoplasma gondii hypothetical protein 0.0016 0.0004 0.0059
Echinococcus granulosus histone lysine methyltransferase setb 0.0127 0.0322 0.0318
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0157 0.0153
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0002 0.0024
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0014 0.0535
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0122 0.0307 1
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0105 0.0242
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0006 0.0017
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0033 0.0465
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0157 0.0624
Onchocerca volvulus 0.0029 0.004 0.0135
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0014 0.001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.006 0.0237
Plasmodium vivax thrombospondin-related anonymous protein 0.0065 0.0144 0.4405
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0056 0.0172
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0056 0.0172
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.006 0.0056
Toxoplasma gondii microneme protein, putative 0.0015 0.0002 0.0024
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0119 0.0472
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0127 0.0322 0.0318
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.006 0.0139
Brugia malayi hypothetical protein 0.0107 0.0264 0.1056
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.006 0.0139
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0042 0.0077 0.0176
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0157 0.443
Echinococcus granulosus dnaJ subfamily B 0.0409 0.113 0.1127
Treponema pallidum 76K protein 0.0065 0.0144 0.0233
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.006 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0077 0.0246
Brugia malayi hypothetical protein 0.0019 0.0012 0.0041
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0017
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0065 0.0144 0.4405
Schistosoma mansoni survival motor neuron protein 0.0056 0.0119 0.0274
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0065 0.0144 0.7573
Echinococcus granulosus Excitatory amino acid transporter 0.0122 0.0307 0.0303
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0006 0.0017
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0065 0.0144 0.4405
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.006 0.0237
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0051 0.085
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0145 0.0335
Echinococcus multilocularis Excitatory amino acid transporter 0.0122 0.0307 0.0303
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0033 0.0233
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0066 0.3353
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0017
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0066 0.0592
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0004 0.001
Echinococcus multilocularis RUN 0.002 0.0014 0.001
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.0079 0.0254
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0006 0.0014
Plasmodium falciparum thrombospondin-related anonymous protein 0.0065 0.0144 0.7573
Brugia malayi von Willebrand factor type A domain containing protein 0.0065 0.0144 0.0573
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.006 0.0207
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0051 0.1588
Schistosoma mansoni hypothetical protein 0.0409 0.113 0.2604
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.006 0.0056
Brugia malayi Bloom's syndrome protein homolog 0.0042 0.0079 0.031
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0077 0.0176
Onchocerca volvulus 0.0065 0.0144 0.0502
Schistosoma mansoni intermediate filament proteins 0.0116 0.0289 0.0667
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0066 0.0209
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0145
Onchocerca volvulus 0.0116 0.0289 0.1015
Brugia malayi hypothetical protein 0.0245 0.066 0.2652
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0081 0.0189 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0144 0.0573
Brugia malayi Doublecortin family protein 0.002 0.0014 0.005
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0065 0.0144 0.0573
Loa Loa (eye worm) hypothetical protein 0.0024 0.0026 0.0097
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0014 0.0311
Brugia malayi hypothetical protein 0.0017 0.0006 0.0018
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0065 0.015
Echinococcus granulosus neutral amino acid transporter 0.0122 0.0307 0.0303
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0053 0.0208
Echinococcus multilocularis lamin 0.0116 0.0289 0.0285
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0054 0.0112 0.0108
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0012 0.0041
Loa Loa (eye worm) hypothetical protein 0.0065 0.0144 0.0573
Brugia malayi cytoplasmic intermediate filament protein 0.0062 0.0135 0.0538
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0056 0.2793
Brugia malayi hypothetical protein 0.0016 0.0004 0.001
Echinococcus multilocularis metabotropic glutamate receptor 5 0.011 0.0273 0.0269
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0017
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0054 0.0112 0.0108
Brugia malayi regulator of G-protein signaling rgs-7 0.0042 0.0077 0.0301
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0056 0.0791
Brugia malayi nuclear receptor RXR 0.0019 0.0012 0.0041
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.0049 0.0147
Echinococcus multilocularis excitatory amino acid transporter 2 0.0122 0.0307 0.0303
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0081 0.0077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0006 0.0002
Entamoeba histolytica hypothetical protein, conserved 0.0065 0.0144 0.4484
Echinococcus multilocularis axis inhibition protein axin 0.0042 0.0077 0.0072
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0006 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.006 0.0237
Brugia malayi nuclear hormone receptor 0.0017 0.0006 0.0017
Schistosoma mansoni cell polarity protein 0.0049 0.0097 0.0223
Schistosoma mansoni aldehyde dehydrogenase 0.026 0.0705 0.1623
Toxoplasma gondii microneme protein MIC17B 0.0015 0.0002 0.0024
Loa Loa (eye worm) RecQ helicase 0.0042 0.0079 0.031
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0033 0.0125
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.0321 1
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0053 0.0208
Loa Loa (eye worm) hypothetical protein 0.0114 0.0283 0.1134
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0081 0.0815
Echinococcus multilocularis Excitatory amino acid transporter 0.0122 0.0307 0.0303
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.006 0.0237
Schistosoma mansoni DNA helicase recq5 0.0029 0.0041 0.0094
Schistosoma mansoni hypothetical protein 0.0024 0.0026 0.006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.006 0.0056
Echinococcus granulosus expressed protein 0.0033 0.0053 0.0049
Loa Loa (eye worm) glutamate receptor 0.0035 0.0058 0.0228
Echinococcus granulosus tissue type plasminogen activator 0.0024 0.0026 0.0022
Brugia malayi PXA domain containing protein 0.0042 0.0077 0.0301
Loa Loa (eye worm) hypothetical protein 0.0065 0.0144 0.0573
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0042 0.0077 0.0301
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0065 0.0061
Brugia malayi hypothetical protein 0.0019 0.0012 0.0041
Echinococcus multilocularis 6 phosphofructokinase 0.0127 0.0321 0.0317
Echinococcus multilocularis slit 2 protein 0.0049 0.0097 0.0093
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0232 0.0624 0.1438
Loa Loa (eye worm) hypothetical protein 0.0049 0.0097 0.0383
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.026 0.0705 0.0701
Toxoplasma gondii microneme protein MIC2 0.0065 0.0144 0.2043
Loa Loa (eye worm) PXA domain-containing protein 0.0042 0.0077 0.0301
Schistosoma mansoni slit 0.0049 0.0097 0.0223
Brugia malayi ecdysone receptor 0.0017 0.0006 0.0017
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0275 0.0746 0.2997
Brugia malayi von Willebrand factor type A domain containing protein 0.0065 0.0144 0.0573
Echinococcus granulosus voltage dependent calcium channel subunit 0.1592 0.4525 0.4523
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0127 0.0322 0.0318
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0056 0.6565
Loa Loa (eye worm) glutamate receptor 0.0089 0.0214 0.0855
Trichomonas vaginalis rotamase, putative 0.0033 0.0053 0.0163
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0041
Brugia malayi Pre-SET motif family protein 0.0127 0.0322 0.1288
Schistosoma mansoni hypothetical protein 0.0822 0.2316 0.5336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.006 0.0237
Entamoeba histolytica hypothetical protein 0.0042 0.0077 0.2385
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.006 0.0139
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0066 0.0259
Loa Loa (eye worm) hypothetical protein 0.0065 0.0144 0.0573
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0122 0.0307 0.0707
Loa Loa (eye worm) serotonin transporter b 0.0016 0.0004 0.001
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.006 0.0139
Echinococcus granulosus axis inhibition protein axin 0.0042 0.0077 0.0072
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.006 0.0139
Loa Loa (eye worm) hypothetical protein 0.0036 0.006 0.0237
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.006 0.0056
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0081 0.032
Schistosoma mansoni rotamase 0.0033 0.0053 0.0123
Mycobacterium ulcerans 6-phosphofructokinase 0.0127 0.0321 0.4502
Loa Loa (eye worm) hypothetical protein 0.0065 0.0144 0.0573
Schistosoma mansoni hypothetical protein 0.0065 0.0144 0.0332
Brugia malayi hypothetical protein 0.0017 0.0007 0.0021
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0004 0.0059
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0006 0.0014
Brugia malayi hypothetical protein 0.0017 0.0006 0.0017
Brugia malayi Regulator of G protein signaling domain containing protein 0.0042 0.0077 0.0301
Trichomonas vaginalis set domain proteins, putative 0.1003 0.2834 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0077 0.0301
Leishmania major hypothetical protein, conserved 0.0026 0.0033 0.0101
Brugia malayi hypothetical protein 0.0026 0.0033 0.0125
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0033 0.0233
Echinococcus granulosus 6 phosphofructokinase 0.0127 0.0321 0.0317
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0065 0.0144 0.0573
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.006 0.0056
Schistosoma mansoni DNA helicase recq1 0.0029 0.0041 0.0094
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0157 0.4298
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0081 0.0187
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0004 0.001
Brugia malayi nuclear receptor NHR-88 0.0017 0.0006 0.0017
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0012 0.0041
Echinococcus granulosus sodium:dicarboxylate symporter 0.0122 0.0307 0.0303
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0041
Schistosoma mansoni sodium-dependent amino acid transporter 0.0016 0.0004 0.001
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0042 0.0077 0.0176
Entamoeba histolytica elongation factor-2 kinase, putative 0.0065 0.0144 0.4484
Schistosoma mansoni hypothetical protein 0.0169 0.0443 0.1021
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0321 0.1111
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0056 0.0791
Echinococcus multilocularis Regulator of G protein signaling 20 0.0042 0.0077 0.0072
Echinococcus granulosus metabotropic glutamate receptor 5 0.011 0.0273 0.0269
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0006 0.0002
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0122 0.0307 0.1077
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0004 0.0059
Loa Loa (eye worm) hypothetical protein 0.0116 0.0289 0.1158
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0016 0.0004 0.001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.006 0.0237
Brugia malayi CXXC zinc finger family protein 0.0029 0.004 0.0153
Brugia malayi Cytochrome P450 family protein 0.007 0.0159 0.0634
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0004 0.001
Brugia malayi phosphofructokinase 0.0127 0.0321 0.1286
Onchocerca volvulus 0.0016 0.0004 0.0009
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0056 0.1704
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Onchocerca volvulus 0.002 0.0014 0.0043
Plasmodium vivax SET domain protein, putative 0.0127 0.0322 1
Brugia malayi hypothetical protein 0.0017 0.0006 0.0017
Loa Loa (eye worm) solute carrier family 6 member 4 0.0016 0.0004 0.001
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0051 0.085
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0081 0.019 0.0758
Schistosoma mansoni lipoxygenase 0.0055 0.0116 0.0267
Schistosoma mansoni thyroid hormone receptor 0.0293 0.0798 0.1837
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0004 0.001
Schistosoma mansoni hypothetical protein 0.0056 0.0119 0.0274
Echinococcus granulosus slit 2 protein 0.0049 0.0097 0.0093
Loa Loa (eye worm) hypothetical protein 0.011 0.0273 0.1093
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.006 0.0056
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0018 0.0162
Brugia malayi ecdysteroid receptor 0.0036 0.006 0.0237
Onchocerca volvulus 0.0127 0.0322 0.1129
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0081 0.0189 0.563
Brugia malayi laminin alpha chain 0.0049 0.0097 0.0383
Echinococcus granulosus geminin 0.0169 0.0443 0.0439
Loa Loa (eye worm) hypothetical protein 0.0036 0.006 0.0237
Loa Loa (eye worm) hypothetical protein 0.0042 0.0077 0.0301
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0257 0.0695 0.0691
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0107 0.0266 0.0262
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.004 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.006 0.0237
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0017
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0065 0.0061
Loa Loa (eye worm) hypothetical protein 0.0051 0.0105 0.0417
Toxoplasma gondii hypothetical protein 0.0016 0.0004 0.0059
Loa Loa (eye worm) hypothetical protein 0.0065 0.0144 0.0573
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0017
Brugia malayi hypothetical protein 0.0042 0.0077 0.0301
Schistosoma mansoni 6-phosphofructokinase 0.0127 0.0321 0.074
Onchocerca volvulus 0.0017 0.0006 0.0015
Echinococcus multilocularis neurogenic locus notch protein 0.0049 0.0097 0.0093
Brugia malayi steroid hormone receptor 0.0036 0.006 0.0237
Schistosoma mansoni loxhd1 0.002 0.0014 0.0032
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0107 0.0266 0.0612
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.006 0.0056
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0881 0.2485 1
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0012 0.0041
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Echinococcus granulosus regulator of G protein signaling 3 0.0042 0.0077 0.0072
Brugia malayi regulator of G-protein signaling egl-10 0.0042 0.0077 0.0301
Echinococcus granulosus lamin dm0 0.0116 0.0289 0.0285
Entamoeba histolytica hypothetical protein 0.0037 0.0065 0.2023
Schistosoma mansoni blooms syndrome DNA helicase 0.0027 0.0036 0.0083
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0049 0.0773
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.006 0.0237
Brugia malayi hypothetical protein 0.002 0.0014 0.005
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.0071 0.3615
Brugia malayi von Willebrand factor type A domain containing protein 0.0065 0.0144 0.0573
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0077 0.0176
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0081 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0004 0.001
Plasmodium falciparum cysteine repeat modular protein 1 0.0024 0.0026 0.1178
Loa Loa (eye worm) hypothetical protein 0.0049 0.0097 0.0383
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0081 0.0189 0.5817
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0017
Toxoplasma gondii microneme protein MIC17C 0.0015 0.0002 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.006 0.0237
Loa Loa (eye worm) hypothetical protein 0.0638 0.1789 0.7197
Loa Loa (eye worm) doublecortin family protein 0.002 0.0014 0.005
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0116 0.0112
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0006 0.0017
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.006 0.0056
Onchocerca volvulus 0.0065 0.0144 0.0502
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0107 0.0266 0.0262
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0041
Echinococcus granulosus cpg binding protein 0.003 0.0045 0.004
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0018 0.0059
Echinococcus granulosus excitatory amino acid transporter 2 0.0122 0.0307 0.0303
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0012 0.0008
Brugia malayi hypothetical protein 0.0065 0.0144 0.0573
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0017
Loa Loa (eye worm) hypothetical protein 0.0042 0.0077 0.0301
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0066 0.796
Toxoplasma gondii endonuclease IV APN 0.0081 0.0189 0.2679
Onchocerca volvulus 0.0065 0.0144 0.0502
Chlamydia trachomatis neutral amino acid transporter 0.0054 0.0112 0.3574
Echinococcus multilocularis axis inhibition protein axin 0.0042 0.0077 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0041
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0016 0.0004 0.001
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0025 0.003 0.0814
Echinococcus multilocularis regulator of G protein signaling 7 0.0042 0.0077 0.0072
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.0705 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0042 0.0077 0.0301
Schistosoma mansoni coup transcription factor 0.0036 0.006 0.0139
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0004 0.001
Toxoplasma gondii PAN/Apple domain-containing protein 0.0015 0.0002 0.0024
Echinococcus granulosus metabotropic glutamate receptor 2 0.0075 0.0172 0.0168
Schistosoma mansoni metabotropic glutamate receptor 0.0075 0.0172 0.0397
Echinococcus multilocularis survival motor neuron protein 1 0.0276 0.0749 0.0745
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.006 0.0237
Echinococcus granulosus beta-adrenergic receptor kinase 0.0042 0.0077 0.0072
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0014 0.001
Echinococcus granulosus RUN 0.002 0.0014 0.001
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0122 0.0307 0.4297
Brugia malayi hypothetical protein 0.0037 0.0065 0.0255
Loa Loa (eye worm) abnormal epIthelia family member 0.0049 0.0097 0.0383
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0065 0.0144 0.4405
Echinococcus multilocularis bloom syndrome protein 0.0042 0.0079 0.0075
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0087
Entamoeba histolytica hypothetical protein, conserved 0.0065 0.0144 0.4484
Onchocerca volvulus 0.0056 0.0119 0.0413
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0077 0.0246
Loa Loa (eye worm) hypothetical protein 0.0065 0.0144 0.0573
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.006 0.0237
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0017
Schistosoma mansoni rab6-interacting 0.002 0.0014 0.0032
Loa Loa (eye worm) hypothetical protein 0.0042 0.0077 0.0301
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0002 0.0024
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0066 0.1361
Echinococcus multilocularis regulator of G protein signaling 0.0042 0.0077 0.0072
Schistosoma mansoni ap endonuclease 0.0038 0.0066 0.0152
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0006 0.0017
Brugia malayi Regulator of G protein signaling domain containing protein 0.0042 0.0077 0.0301
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0006 0.0002
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0066 0.0846
Brugia malayi Sulfatase family protein 0.0017 0.0007 0.0021
Brugia malayi Excitatory amino acid transporter 0.0122 0.0307 0.1229
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0016 0.0002 0.0006
Onchocerca volvulus 0.0036 0.006 0.0207
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0006 0.0002
Echinococcus granulosus intermediate filament protein 0.0116 0.0289 0.0285
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0006 0.0014
Schistosoma mansoni nuclear hormone receptor 0.0036 0.006 0.0139
Echinococcus granulosus regulator of G protein signaling 7 0.0042 0.0077 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.006 0.0237
Treponema pallidum hypothetical protein 0.0065 0.0144 0.0233
Echinococcus granulosus excitatory amino acid transporter 2 0.0122 0.0307 0.0303
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0004 0.001
Brugia malayi hypothetical protein 0.0276 0.0749 0.3007
Brugia malayi nuclear receptor NHR-67 0.0017 0.0006 0.0017
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.0028 0.0403
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0081 0.0189 0.2605
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0081 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.006 0.0237
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0157 0.443
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0014 0.001
Brugia malayi tailless protein 0.0017 0.0006 0.0017
Echinococcus granulosus neurogenic locus notch protein 0.0049 0.0097 0.0093
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.006 0.0139
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.026 0.0705 0.0701
Schistosoma mansoni hypothetical protein 0.0169 0.0443 0.1021
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0066 0.1361
Schistosoma mansoni lamin 0.0116 0.0289 0.0667
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.0322 0.0741
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0017
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0004 0.001
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0018 0.0067
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.026 0.0705 1
Loa Loa (eye worm) excitatory amino acid transporter 0.0122 0.0307 0.1229
Brugia malayi von Willebrand factor type A domain containing protein 0.0065 0.0144 0.0573
Echinococcus granulosus Excitatory amino acid transporter 0.0122 0.0307 0.0303
Echinococcus multilocularis lamin dm0 0.0116 0.0289 0.0285
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0081 0.1873
Loa Loa (eye worm) 6-phosphofructokinase 0.0127 0.0321 0.1286
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0056 0.2793
Brugia malayi von Willebrand factor type A domain containing protein 0.0065 0.0144 0.0573
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0081 0.0077
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0081 0.0077
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.001
Entamoeba histolytica hypothetical protein 0.0037 0.0065 0.2023
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0066 0.0062
Echinococcus granulosus FTZ F1 alpha 0.0036 0.006 0.0056
Echinococcus multilocularis regulator of G protein signaling 3 0.0042 0.0077 0.0072
Echinococcus granulosus leukotriene A 4 hydrolase 0.0232 0.0624 0.062
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0056 0.0118 0.0114
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0023 0.0023 0.0087
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0051 0.037
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0081 0.1679
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0077 0.0176
Brugia malayi hypothetical protein 0.002 0.0014 0.005
Onchocerca volvulus 0.0016 0.0004 0.0009
Onchocerca volvulus 0.0051 0.0105 0.0365
Loa Loa (eye worm) hypothetical protein 0.0036 0.006 0.0237
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.006 0.0237
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0042 0.0077 0.0301
Loa Loa (eye worm) hypothetical protein 0.0056 0.0118 0.0467
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.006 0.0237
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.005
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.006 0.0139
Entamoeba histolytica hypothetical protein 0.0037 0.0065 0.2023
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0075 0.0172 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.006 0.0237
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0056 0.0118 0.0114
Echinococcus granulosus collagen alpha 1VII chain 0.0065 0.0144 0.014
Echinococcus multilocularis beta adrenergic receptor kinase 0.0042 0.0077 0.0072
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0065 0.0144 0.0484
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.006 0.0139

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 12 uM Apparent inhibitory constant against HIV-1 protease was determined ChEMBL. No reference
Ki app (binding) = 12 uM Apparent inhibitory constant against HIV-1 protease was determined ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.