Detailed information for compound 1796995

Basic information

Technical information
  • TDR Targets ID: 1796995
  • Name: 3-(3-methylphenyl)-1-[(1S)-1-phenylethyl]urea
  • MW: 254.327 | Formula: C16H18N2O
  • H donors: 2 H acceptors: 1 LogP: 3.19 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N[C@H](c1ccccc1)C)Nc1cccc(c1)C
  • InChi: 1S/C16H18N2O/c1-12-7-6-10-15(11-12)18-16(19)17-13(2)14-8-4-3-5-9-14/h3-11,13H,1-2H3,(H2,17,18,19)/t13-/m0/s1
  • InChiKey: AUYJIGYLBGXGDY-ZDUSSCGKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC06730896

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.004 0.0469 0.0469
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0687 0.0657
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0061
Entamoeba histolytica hypothetical protein 0.004 0.0469 0.0438
Entamoeba histolytica protein kinase, putative 0.0022 0.0106 0.0074
Brugia malayi Cytohesin 3 0.0019 0.0032 0.0032
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0074
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0022 0.0106 0.0158
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0163 0.2935 0.4407
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.1098 0.1649
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Trypanosoma cruzi hypothetical protein 0.0019 0.0032 0.0048
Schistosoma mansoni serine/threonine protein kinase 0.017 0.3071 0.3397
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0022 0.0106 0.011
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0687 0.0714
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.021 0.0232
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Echinococcus granulosus Pleckstrin y 0.0019 0.0032 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0074
Echinococcus granulosus cpg binding protein 0.0037 0.0395 0.0437
Schistosoma mansoni goodpasture antigen-binding protein 0.0019 0.0032 0.0036
Entamoeba histolytica protein kinase, putative 0.0022 0.0106 0.0074
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0019 0.0032 0.0036
Echinococcus granulosus Rho GTPase activating protein 24 0.0019 0.0032 0.0036
Loa Loa (eye worm) hypothetical protein 0.017 0.3071 0.3071
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0552 0.0877
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0046 0.0051
Leishmania major hypothetical protein, conserved 0.0019 0.0032 0.0048
Brugia malayi hypothetical protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Brugia malayi protein kinase C II. 0.017 0.3071 0.3071
Echinococcus multilocularis Protein kinase C, brain isozyme 0.017 0.3071 0.3397
Leishmania major protein kinase, putative 0.0022 0.0106 0.016
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0001 0.0001
Echinococcus multilocularis calcium dependent secretion activator 1 0.0019 0.0032 0.0036
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0203 0.3745 0.3725
Brugia malayi p70 ribosomal S6 kinase beta 0.0495 0.9623 0.9623
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0329 0.6281 1
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0022 0.0106 0.0105
Trypanosoma cruzi hypothetical protein 0.0019 0.0032 0.0048
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.1098 0.1215
Echinococcus multilocularis serine:threonine protein kinase 38 0.017 0.3071 0.3397
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.1098 0.1098
Trypanosoma cruzi Protein kinase B 0.0348 0.6658 1
Entamoeba histolytica protein kinase 2, putative 0.0329 0.6281 0.6269
Echinococcus multilocularis protein kinase c iota type 0.017 0.3071 0.3397
Schistosoma mansoni atypical protein kinase C 0.017 0.3071 0.3397
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Echinococcus granulosus histone acetyltransferase KAT2B 0.016 0.2887 0.3194
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0074
Loa Loa (eye worm) hypothetical protein 0.0081 0.1278 0.1278
Onchocerca volvulus 0.0033 0.0314 0.0759
Brugia malayi Dynamin 0.0019 0.0032 0.0032
Trypanosoma brucei PH domain containing protein, putative 0.0019 0.0032 0.0032
Loa Loa (eye worm) oxysterol binding protein 0.0019 0.0032 0.0032
Brugia malayi probable spectrin beta chain 0.0019 0.0032 0.0032
Trypanosoma cruzi ISWI complex protein 0.0017 0.0006 0.0008
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.017 0.3071 0.3397
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0019 0.0032 0.0036
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0325 0.6207 0.6866
Schistosoma mansoni serine/threonine kinase 0.017 0.3071 0.3397
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0061 0.0067
Entamoeba histolytica hypothetical protein 0.0022 0.0106 0.0074
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0074
Schistosoma mansoni serine/threonine protein kinase 0.017 0.3071 0.3397
Loa Loa (eye worm) hypothetical protein 0.006 0.0866 0.0866
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.048 0.053
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0019 0.0032 0.0036
Brugia malayi Bromodomain containing protein 0.0091 0.1495 0.1495
Schistosoma mansoni myotubularin-related protein 0.0019 0.0032 0.0036
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0022 0.0106 0.0158
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0203 0.3745 0.3725
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0019 0.0032 0.005
Echinococcus granulosus beta 1 syntrophin 0.0019 0.0032 0.0036
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.063 0.0945
Brugia malayi PH domain containing protein 0.0019 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Brugia malayi Dynamin 0.0019 0.0032 0.0032
Echinococcus multilocularis Oxysterol binding protein 11 0.0019 0.0032 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0916 0.1375
Echinococcus granulosus dynamin 1 0.0019 0.0032 0.0036
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0203 0.3745 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0203 0.3745 0.3725
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.017 0.3071 0.3397
Echinococcus multilocularis pdz domain containing protein 0.0019 0.0032 0.0036
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0314 0.0314
Trichomonas vaginalis AGC family protein kinase 0.017 0.3071 0.3049
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.1098 0.107
Brugia malayi Cadps2 protein 0.0019 0.0032 0.0032
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0019 0.0032 0.0032
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0687 0.1094
Echinococcus granulosus Pleckstrin y 0.0019 0.0032 0.0036
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0019 0.0032 0.0036
Loa Loa (eye worm) hypothetical protein 0.0054 0.0753 0.0753
Toxoplasma gondii hypothetical protein 0.0019 0.0032 0.0033
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0066 0.0034
Brugia malayi Bromodomain containing protein 0.0048 0.0615 0.0615
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0552 0.0521
Brugia malayi Syntrophin-1 0.0019 0.0032 0.0032
Brugia malayi hypothetical protein 0.0019 0.0032 0.0032
Leishmania major mitochondrial DNA polymerase beta 0.0344 0.6585 1
Brugia malayi PH domain containing protein 0.0019 0.0032 0.0032
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0329 0.6281 0.6948
Echinococcus granulosus Pleckstrin y 0.0019 0.0032 0.0036
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0019 0.0032 0.0036
Leishmania major hypothetical protein, conserved 0.0019 0.0032 0.0048
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0046 0.0051
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0106 0.0074
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.063 0.0945
Loa Loa (eye worm) hypothetical protein 0.005 0.0671 0.0671
Brugia malayi PHD-finger family protein 0.0034 0.0346 0.0346
Schistosoma mansoni syntrophin 0.0019 0.0032 0.0036
Echinococcus multilocularis protein kinase c epsilon type 0.017 0.3071 0.3397
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0019 0.0032 0.0036
Echinococcus granulosus Oxysterol binding protein 11 0.0019 0.0032 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0513 1 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0106 0.0074
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.014 0.2484 0.7515
Trypanosoma cruzi hypothetical protein 0.0019 0.0032 0.0048
Trypanosoma brucei protein kinase, putative 0.0022 0.0106 0.0105
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Entamoeba histolytica hypothetical protein 0.004 0.0469 0.0438
Echinococcus multilocularis dynamin 1 0.0019 0.0032 0.0036
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0019 0.0032 0.005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0206 0.0206
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0074
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.1039 0.108
Echinococcus multilocularis Pleckstrin y 0.0019 0.0032 0.0036
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0495 0.9623 0.9623
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0074
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0032 0.005
Echinococcus multilocularis Pleckstrin y 0.0019 0.0032 0.0036
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0203 0.3745 0.3725
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0066 0.0034
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.017 0.3071 0.3071
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0348 0.6658 1
Echinococcus granulosus oxysterol binding protein 1 0.0019 0.0032 0.0036
Echinococcus multilocularis serine threonine protein kinase 0.017 0.3071 0.3397
Loa Loa (eye worm) AGC/PKN protein kinase 0.017 0.3071 0.3071
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0168 0.3035 0.3357
Schistosoma mansoni serine/threonine-protein kinase 0.0348 0.6658 0.7365
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0066 0.0066
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0206 0.0214
Schistosoma mansoni zinc finger protein 0.0019 0.0032 0.0036
Leishmania major hypothetical protein, conserved 0.0027 0.0206 0.0312
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.1053 0.1165
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0491 0.0543
Echinococcus granulosus serine/threonine protein kinase 0.0348 0.6658 0.7365
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0745 0.0745
Schistosoma mansoni hypothetical protein 0.004 0.0469 0.0518
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0022 0.0106 0.0158
Echinococcus multilocularis pleckstrin y domain containing family A 0.0019 0.0032 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0019 0.0032 0.0036
Loa Loa (eye worm) syntrophin-1 0.0019 0.0032 0.0032
Brugia malayi PH domain containing protein 0.0019 0.0032 0.0032
Echinococcus multilocularis GRB2 associated binding protein 3 0.0019 0.0032 0.0036
Echinococcus granulosus nervana 2 0.0325 0.6207 0.6866
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0019 0.0032 0.005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0019 0.0032 0.0032
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0019 0.0032 0.0048
Echinococcus granulosus oxysterol binding protein 9 0.0019 0.0032 0.0036
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.1098 0.1215
Trichomonas vaginalis AGC family protein kinase 0.0513 1 1
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0019 0.0032 0.0032
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0019 0.0032 0.0032
Brugia malayi Ets-domain containing protein 0.007 0.1071 0.1071
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0032 0.0032
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0066 0.0105
Echinococcus multilocularis DCC interacting protein 13 beta 0.0019 0.0032 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0513 1 1
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0513 1 1
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0019 0.0032 0.0036
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0019 0.0032 0.0036
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0001 0.0001
Giardia lamblia Kinase, AGC PKA 0.0329 0.6281 1
Echinococcus granulosus cytohesin 1 0.0019 0.0032 0.0036
Trypanosoma cruzi PH domain containing protein, putative 0.0019 0.0032 0.0048
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0203 0.3745 0.3725
Schistosoma mansoni centaurin alpha 0.0019 0.0032 0.0036
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0163 0.2935 0.4456
Echinococcus multilocularis beta 1 syntrophin 0.0019 0.0032 0.0036
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0046 0.0051
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0745 0.0745
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0066 0.0199
Echinococcus granulosus oxysterol binding protein 3 0.0019 0.0032 0.0036
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0022 0.0106 0.0158
Echinococcus granulosus Glutaredoxin protein 5 0.0325 0.6207 0.6866
Schistosoma mansoni dynamin 0.0019 0.0032 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0344 0.6585 0.989
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0916 0.1375
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0745 0.0745
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0022 0.0106 0.016
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0203 0.3745 0.3745
Brugia malayi Oxysterol binding protein 0.0019 0.0032 0.0032
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0203 0.3745 0.3725
Schistosoma mansoni oxysterol-binding protein 1 0.0019 0.0032 0.0036
Trypanosoma cruzi PH domain containing protein, putative 0.0019 0.0032 0.0048
Schistosoma mansoni vav2 0.0019 0.0032 0.0036
Echinococcus granulosus calcium dependent secretion activator 1 0.0019 0.0032 0.0036
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0001 0.0001
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0129 0.0129
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.021 0.0232
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0019 0.0032 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.017 0.3071 0.3397
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0022 0.0106 0.0105
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0074
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0063 0.0916 0.0886
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0022 0.0106 0.0158
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0063 0.0916 0.0915
Schistosoma mansoni oxysterol-binding protein 1 0.0019 0.0032 0.0036
Trypanosoma cruzi hypothetical protein 0.0019 0.0032 0.0048
Echinococcus granulosus protein kinase c iota type 0.017 0.3071 0.3397
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0206 0.0328
Brugia malayi PH domain containing protein 0.0019 0.0032 0.0032
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0687 0.076
Echinococcus granulosus GRB2 associated binding protein 3 0.0019 0.0032 0.0036
Brugia malayi Hr1 repeat family protein 0.017 0.3071 0.3071
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0206 0.0328
Plasmodium falciparum calcium-dependent protein kinase 7 0.0022 0.0106 0.0168
Echinococcus granulosus dnaJ subfamily B 0.0466 0.904 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0687 0.0714
Loa Loa (eye worm) AGC/NDR protein kinase 0.017 0.3071 0.3071
Entamoeba histolytica p21-activated kinase 0.0022 0.0106 0.0074
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0022 0.0106 0.0105
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0344 0.6585 0.989
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0066 0.5
Entamoeba histolytica PH domain containing protein kinase, putative 0.0348 0.6658 0.6647
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0061 0.0067
Schistosoma mansoni zinc finger protein 0.0019 0.0032 0.0036
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.017 0.3071 0.3397
Toxoplasma gondii hypothetical protein 0.0055 0.0773 0.0803
Brugia malayi Ets-domain containing protein 0.007 0.1071 0.1071
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0019 0.0032 0.0036
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0019 0.0032 0.005
Toxoplasma gondii protein kinase domain-containing protein 0.0022 0.0106 0.011
Brugia malayi Plekhf2 protein 0.0019 0.0032 0.0032
Schistosoma mansoni cpg binding protein 0.0037 0.0395 0.0437
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0203 0.3745 0.3725
Onchocerca volvulus 0.0203 0.3745 1
Schistosoma mansoni zinc finger protein 0.0017 0.0006 0.0007
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0163 0.2935 0.2934
Loa Loa (eye worm) acetyltransferase 0.0168 0.3035 0.3035
Schistosoma mansoni hypothetical protein 0.0466 0.904 1
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.017 0.3071 0.3071
Echinococcus multilocularis nervana 2 0.0325 0.6207 0.6866
Trypanosoma cruzi NIMA-related kinase, putative 0.0022 0.0106 0.0158
Schistosoma mansoni dynamin 0.0019 0.0032 0.0036
Toxoplasma gondii AGC kinase 0.0495 0.9623 1
Trypanosoma cruzi ISWI complex protein 0.0017 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.1071 0.1185
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0019 0.0032 0.0036
Echinococcus multilocularis serine:threonine protein kinase N2 0.017 0.3071 0.3397
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.1098 0.1215
Schistosoma mansoni bromodomain containing protein 0.0078 0.1226 0.1356
Echinococcus multilocularis myotubularin protein 13 0.0019 0.0032 0.0036
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0019 0.0032 0.0032
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.063 0.0629
Echinococcus multilocularis oxysterol binding protein 1 0.0019 0.0032 0.0036
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0066 0.5
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0203 0.3745 0.5919
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.017 0.3071 0.3397
Leishmania major serine/threonine-protein kinase a, putative 0.0022 0.0106 0.016
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0022 0.0106 0.0158
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0066 0.0073
Brugia malayi PH domain containing protein 0.0019 0.0032 0.0032
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0203 0.3745 0.3725
Trichomonas vaginalis AGC family protein kinase 0.0513 1 1
Brugia malayi Protein kinase domain containing protein 0.017 0.3071 0.3071
Echinococcus granulosus pleckstrin y domain containing family A 0.0019 0.0032 0.0036
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0001 0.0001
Echinococcus multilocularis zinc finger protein 0.0028 0.0223 0.0247
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.04 0.04
Trypanosoma cruzi PH domain containing protein, putative 0.0019 0.0032 0.0048
Trichomonas vaginalis AGC family protein kinase 0.017 0.3071 0.3049
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0074
Brugia malayi PH domain containing protein 0.0019 0.0032 0.0032
Loa Loa (eye worm) AGC/AKT protein kinase 0.0513 1 1
Echinococcus multilocularis actin binding protein anillin 0.0019 0.0032 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0491 0.0543
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0066 0.0099
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0469 0.0518
Echinococcus multilocularis Pleckstrin y 0.0019 0.0032 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0074
Entamoeba histolytica protein kinase, putative 0.0495 0.9623 0.9622
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0106 0.0074
Trypanosoma cruzi hypothetical protein 0.0019 0.0032 0.0048
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0066 0.0073
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.1098 0.1098
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0843 0.1265
Echinococcus granulosus protein kinase c epsilon type 0.017 0.3071 0.3397
Brugia malayi acetyltransferase, GNAT family protein 0.0168 0.3035 0.3035
Echinococcus granulosus Protein kinase C brain isozyme 0.017 0.3071 0.3397
Echinococcus granulosus serine threonine protein kinase nrc 0.0329 0.6281 0.6948
Entamoeba histolytica protein kinase, putative 0.0513 1 1
Plasmodium falciparum oxysterol-binding protein, putative 0.0019 0.0032 0.005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Loa Loa (eye worm) uncoordinated protein 104 0.0019 0.0032 0.0032
Echinococcus multilocularis nervana 2 0.0325 0.6207 0.6866
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0019 0.0032 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0074
Mycobacterium tuberculosis Conserved hypothetical protein 0.0181 0.3305 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0001 0.0001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0001 0.0001
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0206 0.0206
Brugia malayi TBC domain containing protein 0.0019 0.0032 0.0032
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.017 0.3071 0.3397
Schistosoma mansoni hypothetical protein 0.0019 0.0032 0.0036
Toxoplasma gondii phosphatidylinositol transfer protein 0.0019 0.0032 0.0033
Toxoplasma gondii AtPH1 family protein 0.0019 0.0032 0.0033
Schistosoma mansoni hypothetical protein 0.0019 0.0032 0.0036
Mycobacterium ulcerans hypothetical protein 0.0181 0.3305 0.8805
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0019 0.0032 0.0048
Echinococcus multilocularis Ras associated and pleckstrin y 0.0019 0.0032 0.0036
Schistosoma mansoni hypothetical protein 0.0019 0.0032 0.0036
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0019 0.0032 0.0036
Brugia malayi PH domain containing protein 0.0019 0.0032 0.0032
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0019 0.0032 0.005
Leishmania major hypothetical protein, conserved 0.0017 0.0006 0.0008
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.017 0.3071 0.3071
Echinococcus granulosus myotubularin protein 13 0.0019 0.0032 0.0036
Trypanosoma cruzi PH domain containing protein, putative 0.0019 0.0032 0.0048
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0074
Brugia malayi Protein kinase domain containing protein 0.017 0.3071 0.3071
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0066 0.0099
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0019 0.0032 0.0036
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0106 0.0074
Echinococcus granulosus zinc finger protein 0.0028 0.0223 0.0247
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Entamoeba histolytica protein kinase, putative 0.0022 0.0106 0.0074
Brugia malayi Oxysterol-binding protein 0.0019 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0022 0.0106 0.0105
Brugia malayi Fli-1 protein 0.0213 0.3955 0.3955
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0019 0.0032 0.005
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0066 0.0066
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0329 0.6281 1
Leishmania major folate/biopterin transporter, putative 0.0022 0.0106 0.016
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0061 0.0067
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0203 0.3745 0.3745
Toxoplasma gondii hypothetical protein 0.0019 0.0032 0.0033
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0066 0.0105
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0019 0.0032 0.0036
Echinococcus multilocularis oxysterol binding protein 3 0.0019 0.0032 0.0036
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0329 0.6281 0.9433
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0206 0.0328
Trypanosoma brucei rac serine-threonine kinase, putative 0.0513 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.0032 0.0036
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.1098 0.1649
Schistosoma mansoni hypothetical protein 0.0023 0.0129 0.0142
Loa Loa (eye worm) rho-GTPase-activating 0.0019 0.0032 0.0032
Brugia malayi isocitrate dehydrogenase 0.0017 0.0001 0.0001
Leishmania major protein kinase, putative 0.0022 0.0106 0.016
Schistosoma mansoni cpg binding protein 0.0033 0.0314 0.0347
Entamoeba histolytica hypothetical protein 0.0022 0.0106 0.0074
Loa Loa (eye worm) Plekhf2 protein 0.0019 0.0032 0.0032
Brugia malayi CXXC zinc finger family protein 0.0033 0.0314 0.0314
Schistosoma mansoni serine/threonine protein kinase 0.017 0.3071 0.3397
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0066 0.0034
Trichomonas vaginalis AGC family protein kinase 0.0513 1 1
Echinococcus multilocularis Glutaredoxin protein 5 0.0325 0.6207 0.6866
Echinococcus multilocularis cytohesin 1 0.0019 0.0032 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0074
Echinococcus granulosus serine:threonine protein kinase N2 0.017 0.3071 0.3397
Echinococcus granulosus DCC interacting protein 13 beta 0.0019 0.0032 0.0036
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0022 0.0106 0.016
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0022 0.0106 0.0168
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0073
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.1071 0.1071
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0344 0.6585 0.6585
Loa Loa (eye worm) PH domain-containing protein 0.0019 0.0032 0.0032
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0019 0.0032 0.0048
Schistosoma mansoni ets-related 0.0213 0.3955 0.4375
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0022 0.0106 0.0074
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0687 0.0657
Entamoeba histolytica protein kinase, putative 0.0513 1 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.017 0.3071 0.3397
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0001 0.0001
Echinococcus multilocularis cpg binding protein 0.0037 0.0395 0.0437
Trypanosoma cruzi hypothetical protein 0.0019 0.0032 0.0048
Loa Loa (eye worm) hypothetical protein 0.0037 0.04 0.04
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.1144 0.1265
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.1098 0.1098
Brugia malayi PH domain containing protein 0.0019 0.0032 0.0032
Loa Loa (eye worm) fli-1 protein 0.0213 0.3955 0.3955
Schistosoma mansoni goodpasture antigen-binding protein 0.0019 0.0032 0.0036
Plasmodium falciparum PH domain-containing protein, putative 0.0019 0.0032 0.005
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0142 0.0142
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0168 0.3035 0.3357
Toxoplasma gondii exonuclease III APE 0.002 0.0066 0.0068
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0022 0.0106 0.0158
Echinococcus granulosus NDR protein kinase 0.017 0.3071 0.3397
Schistosoma mansoni hypothetical protein 0.0017 0.0006 0.0007
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0022 0.0106 0.0158
Entamoeba histolytica PH domain containing protein kinase, putative 0.0348 0.6658 0.6647
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.1098 0.1667
Plasmodium vivax PH domain containing protein 0.0019 0.0032 0.005
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0022 0.0106 0.0074
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0063 0.0916 0.0886
Schistosoma mansoni gabp alpha 0.007 0.1071 0.1185
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0032 0.0032
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0001 0.0001
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0074
Trypanosoma cruzi NIMA-related kinase, putative 0.0022 0.0106 0.0158
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.021 0.0232
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Echinococcus granulosus pdz domain containing protein 0.0019 0.0032 0.0036
Schistosoma mansoni zinc finger protein 0.0028 0.0223 0.0247
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0046 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.017 0.3071 0.3397
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0469 0.0518
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.017 0.3071 0.3071
Trichomonas vaginalis AGC family protein kinase 0.0513 1 1
Echinococcus multilocularis dnaJ subfamily B 0.0466 0.904 1
Schistosoma mansoni serine/threonine protein kinase 0.017 0.3071 0.3397
Brugia malayi Pleckstrin Homology Domain 0.0019 0.0032 0.0032
Entamoeba histolytica protein kinase, putative 0.017 0.3071 0.3049
Trypanosoma cruzi hypothetical protein 0.0019 0.0032 0.0048
Loa Loa (eye worm) hypothetical protein 0.0044 0.0536 0.0536
Entamoeba histolytica hypothetical protein 0.004 0.0469 0.0438
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.1144 0.1265
Schistosoma mansoni hypothetical protein 0.0037 0.04 0.0443
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0061 0.0067
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0325 0.6207 0.6866
Brugia malayi hypothetical protein 0.0027 0.0206 0.0206
Entamoeba histolytica hypothetical protein 0.004 0.0469 0.0438
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0066 0.01
Loa Loa (eye worm) cytohesin 3 0.0019 0.0032 0.0032
Schistosoma mansoni serine/threonine-protein kinase 0.0348 0.6658 0.7365
Schistosoma mansoni serine/threonine protein kinase 0.017 0.3071 0.3397
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0329 0.6281 0.6948
Schistosoma mansoni growth factor receptor-bound protein 0.0019 0.0032 0.0036
Echinococcus granulosus GA binding protein alpha chain 0.007 0.1071 0.1185
Toxoplasma gondii Oxysterol-binding protein 0.0019 0.0032 0.0033
Brugia malayi PH domain containing protein 0.0019 0.0032 0.0032
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0019 0.0032 0.0032
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0019 0.0032 0.0032
Echinococcus multilocularis oxysterol binding protein 9 0.0019 0.0032 0.0036
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.063 0.0945
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0074
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0019 0.0032 0.0036
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.048 0.053
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0019 0.0032 0.0036
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0166 0.2997 0.2975
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0469 0.0518
Brugia malayi Uncoordinated protein 104 0.0019 0.0032 0.0032
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0001 0.0001
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0074
Trypanosoma brucei ISWI complex protein 0.0017 0.0006 0.0006
Schistosoma mansoni rho gtpase activating protein 0.0019 0.0032 0.0036
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.017 0.3071 0.3397
Echinococcus granulosus nervana 2 0.0325 0.6207 0.6866
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0019 0.0032 0.0036
Leishmania major hypothetical protein, conserved 0.0063 0.0916 0.139
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0074
Trichomonas vaginalis AGC family protein kinase 0.017 0.3071 0.3049
Entamoeba histolytica protein kinase, putative 0.0022 0.0106 0.0074
Echinococcus multilocularis Rho GTPase activating protein 24 0.0019 0.0032 0.0036
Entamoeba histolytica protein kinase, putative 0.0022 0.0106 0.0074
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0206 0.0309
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0032
Echinococcus granulosus protein kinase C gamma type 0.017 0.3071 0.3397
Loa Loa (eye worm) hypothetical protein 0.0054 0.0745 0.0745
Echinococcus multilocularis rac serine:threonine kinase 0.0348 0.6658 0.7365
Trichomonas vaginalis AGC family protein kinase 0.0188 0.3448 0.3427
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0552 0.0781
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0019 0.0032 0.0036
Brugia malayi MAX-1A 0.0019 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0019 0.0032 0.0036
Schistosoma mansoni cpg binding protein 0.0037 0.0395 0.0437
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0106 0.0074
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0206 0.0309

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = 10 % Phytotoxicity against directly seeded Oryza sativa (rice) seedlings assessed as phytotoxic activity ratings (0- no effect to 5-complete killing rating scale) at 100 g/a measured after 3 weeks post compound treatment under green house conditions ChEMBL. 27393589
Activity (functional) = 79 % Relieving activity against bensulfuron-methyl induced injury to Oryza sativa (rice) assessed as growth rate at 1 uM (Rbv = 46 to 53%) ChEMBL. 27393060

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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