Detailed information for compound 181518

Basic information

Technical information
  • TDR Targets ID: 181518
  • Name: 4-(2-cyclopropylethynyl)-6-(methylamino)-4-(t rifluoromethyl)-1H-3,1-benzoxazin-2-one
  • MW: 310.271 | Formula: C15H13F3N2O2
  • H donors: 2 H acceptors: 1 LogP: 3.37 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNc1ccc2c(c1)C(C#CC1CC1)(OC(=O)N2)C(F)(F)F
  • InChi: 1S/C15H13F3N2O2/c1-19-10-4-5-12-11(8-10)14(15(16,17)18,22-13(21)20-12)7-6-9-2-3-9/h4-5,8-9,19H,2-3H2,1H3,(H,20,21)
  • InChiKey: GKLDOEFIEUOYHQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2-cyclopropylethynyl)-6-methylamino-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
  • Cyclopropylethynyl-methylamino-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one
  • Benzoxazinone deriv. 7a
  • AIDS-085992
  • AIDS085992

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Schistosoma mansoni hypothetical protein Get druggable targets OG5_139608 All targets in OG5_139608
Plasmodium yoelii integrase-related Get druggable targets OG5_139608 All targets in OG5_139608
Trypanosoma brucei RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0077 0.0148 0.0215
Schistosoma mansoni hypothetical protein 0.0046 0.002 0.0015
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.2459 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0693 0.076
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0064 0.0098 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0136 0.0114
Schistosoma mansoni intermediate filament proteins 0.0135 0.0391 0.0387
Schistosoma mansoni hypothetical protein 0.0081 0.0167 0.0163
Giardia lamblia Hypothetical protein 0.0064 0.0098 0.0058
Trypanosoma brucei thymidylate kinase, putative 0.029 0.1031 0.1792
Entamoeba histolytica hypothetical protein 0.0064 0.0098 0.011
Schistosoma mansoni thyroid hormone receptor 0.0169 0.0531 0.0526
Schistosoma mansoni lamin 0.0135 0.0391 0.0387
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.0237 0.0809 0.0791
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.0207 0.0229
Loa Loa (eye worm) polyprenyl synthetase 0.1401 0.5624 0.6165
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0163 0.0504 0.05
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1401 0.5624 1
Schistosoma mansoni glutathione synthetase 0.0412 0.1536 0.1532
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0412 0.1536 0.2695
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0077 0.0148 0.0129
Trypanosoma brucei PAB1-binding protein , putative 0.0102 0.0252 0.04
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0107 0.0272 0.0395
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.04 0.0381
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0139 0.0179
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0141 0.0413 0.0622
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0064 0.0098 0.0125
Brugia malayi hypothetical protein 0.0102 0.0252 0.0362
Schistosoma mansoni hypothetical protein 0.0862 0.3397 0.3394
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0412 0.1536 0.2695
Echinococcus multilocularis Glycosyl transferase, family 35 0.0111 0.0291 0.0272
Echinococcus multilocularis carbonic anhydrase 0.0141 0.0413 0.0394
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0486 0.1841 0.2928
Loa Loa (eye worm) intermediate filament protein 0.0135 0.0391 0.0429
Echinococcus multilocularis 0.0064 0.0098 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Brugia malayi Matrixin family protein 0.0211 0.0706 0.1096
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1401 0.5624 0.9039
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0114 0.0302 0.0443
Trichomonas vaginalis glycogen phosphorylase, putative 0.0111 0.0291 0.0366
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0095 0.0222 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0196 0.0212
Echinococcus multilocularis transfer RNA-Ile 0.1223 0.4889 0.4879
Echinococcus granulosus glycogen phosphorylase 0.0111 0.0291 0.0272
Mycobacterium ulcerans thymidylate kinase 0.029 0.1031 0.1789
Trypanosoma cruzi target of rapamycin kinase 3 0.0097 0.0234 0.0333
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0495 0.1879 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.0139 0.0176
Loa Loa (eye worm) hypothetical protein 0.0141 0.0413 0.0452
Echinococcus granulosus survival motor neuron protein 1 0.0954 0.3775 0.3763
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.1218 0.4869 0.7811
Echinococcus multilocularis solute carrier family 28 0.0363 0.1331 0.1314
Brugia malayi Bromodomain containing protein 0.0075 0.0142 0.0184
Loa Loa (eye worm) TAR-binding protein 0.0128 0.0361 0.0396
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.04 0.0396
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0095 0.0222 0.0203
Loa Loa (eye worm) hypothetical protein 0.0455 0.1713 0.1878
Schistosoma mansoni hypothetical protein 0.0068 0.0114 0.011
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0421 0.1574 0.25
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0281 0.0995 0.0977
Schistosoma mansoni glycogen phosphorylase 0.0111 0.0291 0.0286
Brugia malayi hypothetical protein 0.0066 0.0103 0.0121
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0278 0.0274
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0064 0.0098 0.0113
Schistosoma mansoni hypothetical protein 0.0862 0.3397 0.3394
Leishmania major thymidine kinase, putative 0.1019 0.4044 0.7177
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.0139 0.0119
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0058 0.0039
Schistosoma mansoni hypothetical protein 0.029 0.1031 0.1027
Loa Loa (eye worm) hypothetical protein 0.0064 0.0098 0.0107
Chlamydia trachomatis thymidylate kinase 0.029 0.1031 0.4659
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0412 0.1536 0.2695
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0095 0.0222 0.0244
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.007 0.0121 0.0116
Echinococcus granulosus carbonic anhydrase 0.0141 0.0413 0.0394
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.04 0.0439
Onchocerca volvulus Putative thymidylate kinase 0.029 0.1031 0.5857
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.0057 0.0066 0.0061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.04 0.0381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Loa Loa (eye worm) hypothetical protein 0.0954 0.3775 0.4138
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.033 0.0362
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.007 0.0121 0.0167
Brugia malayi Matrixin family protein 0.0057 0.0068 0.0066
Entamoeba histolytica protein kinase rad3, putative 0.007 0.0121 0.0147
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0274 0.0963 0.1671
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1401 0.5624 0.9039
Echinococcus multilocularis thymidylate kinase 0.029 0.1031 0.1013
Entamoeba histolytica glycogen phosphorylase, putative 0.0111 0.0291 0.0422
Trichomonas vaginalis thymidine kinase, putative 0.1019 0.4044 0.647
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0486 0.1841 0.293
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0064 0.0098 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0148 0.0134
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0361 0.0357
Onchocerca volvulus 0.0057 0.0068 0.0017
Brugia malayi RNA binding protein 0.0128 0.0361 0.0539
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.0381 0.0362
Loa Loa (eye worm) phosphatidylinositol 3 0.0064 0.0098 0.0107
Onchocerca volvulus Glycogen phosphorylase homolog 0.0111 0.0291 0.1367
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0107 0.0272 0.0391
Brugia malayi Matrixin family protein 0.0057 0.0068 0.0066
Toxoplasma gondii hypothetical protein 0.0141 0.0413 0.0688
Schistosoma mansoni lipoxygenase 0.0055 0.0058 0.0054
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0573 0.2202 0.2187
Loa Loa (eye worm) hypothetical protein 0.0043 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0057 0.0068 0.0075
Loa Loa (eye worm) hypothetical protein 0.0455 0.1713 0.1878
Entamoeba histolytica hypothetical protein 0.0108 0.0278 0.0402
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0141 0.0413 0.0622
Echinococcus granulosus serine protein kinase ATM 0.007 0.0121 0.0101
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0079 0.0059
Schistosoma mansoni thymidylate kinase 0.029 0.1031 0.1027
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1401 0.5624 1
Entamoeba histolytica cytidine deaminase, putative 0.0057 0.0066 0.0057
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0236 0.0806 0.0884
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1401 0.5624 0.9039
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0274 0.0963 0.1509
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0141 0.0413 0.0622
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0412 0.1536 0.2435
Brugia malayi Matrixin family protein 0.0057 0.0068 0.0066
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1401 0.5624 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0245 0.0351
Echinococcus multilocularis cytidine deaminase 0.0057 0.0066 0.0046
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0058 0.0039
Loa Loa (eye worm) hypothetical protein 0.01 0.0245 0.0269
Loa Loa (eye worm) RNA binding protein 0.0128 0.0361 0.0396
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0047 0.0028 0.0008
Trypanosoma cruzi thymidylate kinase, putative 0.029 0.1031 0.1621
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0064 0.0098 0.0113
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0095 0.0222 0.0482
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.007 0.0121 0.0151
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0274 0.0963 0.1459
Entamoeba histolytica hypothetical protein 0.0108 0.0278 0.0402
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1401 0.5624 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Loa Loa (eye worm) runx1 0.0057 0.0067 0.0074
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0064 0.0098 0.0125
Toxoplasma gondii thymidylate kinase 0.029 0.1031 0.1792
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0067 0.0106 0.0141
Loa Loa (eye worm) hypothetical protein 0.0811 0.3187 0.3493
Trichomonas vaginalis glycogen phosphorylase, putative 0.0111 0.0291 0.0366
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0065 0.0101 0.0082
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1544 0.6215 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0028 0.0008
Trypanosoma brucei thymidylate kinase, putative 0.029 0.1031 0.1792
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0067 0.0106 0.0278
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.007 0.0121 0.0147
Brugia malayi follicle stimulating hormone receptor 0.024 0.0823 0.1285
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0083 0.0174 0.0261
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.0363 0.1331 0.1314
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1401 0.5624 1
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0412 0.1536 0.2692
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0236 0.0806 0.1259
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.0139 0.0198
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0274 0.0963 0.1671
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0026 0.0006
Schistosoma mansoni hypothetical protein 0.0064 0.0098 0.0093
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0274 0.0963 0.1512
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.007 0.0121 0.0151
Schistosoma mansoni carbonic anhydrase 0.0141 0.0413 0.0408
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0139 0.0119
Leishmania major polyprenyl synthase, putative 0.0573 0.2202 0.3886
Echinococcus multilocularis lamin 0.0135 0.0391 0.0372
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.008 0.0163 0.0242
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0114 0.0302 0.0443
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Schistosoma mansoni lozenge 0.0057 0.0067 0.0063
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0412 0.1536 0.2695
Plasmodium vivax hypothetical protein 0.0064 0.0098 0.0125
Echinococcus multilocularis geminin 0.0862 0.3397 0.3384
Onchocerca volvulus 0.0081 0.0167 0.0619
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0125 0.0097
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0274 0.0963 0.1459
Plasmodium falciparum carbonic anhydrase 0.0141 0.0413 0.0688
Loa Loa (eye worm) phosphatidylinositol 3 0.0064 0.0098 0.0107
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0278 0.0259
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.0361 0.0539
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.04 0.0602
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.04 0.0396
Brugia malayi Polyprenyl synthetase family protein 0.1401 0.5624 0.9044
Echinococcus multilocularis thymidine kinase 0.1223 0.4889 0.4879
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0236 0.0806 0.1259
Echinococcus multilocularis lamin dm0 0.0135 0.0391 0.0372
Trichomonas vaginalis thymidine kinase, putative 0.1019 0.4044 0.647
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0811 0.3187 0.3173
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0573 0.2202 0.2199
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0274 0.0963 0.1056
Onchocerca volvulus Matrilysin homolog 0.02 0.0658 0.3598
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0064 0.0098 0.0093
Echinococcus granulosus serine:threonine protein kinase SMG1 0.007 0.0121 0.0101
Loa Loa (eye worm) hypothetical protein 0.0732 0.286 0.3135
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0064 0.0098 0.0125
Schistosoma mansoni survival motor neuron protein 0.0195 0.0636 0.0631
Echinococcus granulosus geminin 0.0862 0.3397 0.3384
Trypanosoma brucei carbonic anhydrase-like protein 0.0236 0.0806 0.1392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0195 0.0636 0.0983
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0064 0.0098 0.0078
Entamoeba histolytica Thymidylate kinase, putative 0.029 0.1031 0.1618
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0064 0.0098 0.0125
Brugia malayi hypothetical protein 0.0077 0.0152 0.02
Loa Loa (eye worm) phosphatidylinositol 3 0.2247 0.9122 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0274 0.0963 0.1671
Loa Loa (eye worm) carbonic anhydrase 3 0.0236 0.0806 0.0884
Mycobacterium leprae PROBABLE HYDROLASE 0.007 0.012 0.0371
Echinococcus granulosus lamin dm0 0.0135 0.0391 0.0372
Echinococcus multilocularis musashi 0.0135 0.0391 0.0372
Brugia malayi exodeoxyribonuclease III family protein 0.0095 0.0222 0.0315
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0495 0.1879 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0121 0.009
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0486 0.1841 0.2887
Schistosoma mansoni lamin 0.0135 0.0391 0.0387
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0163 0.0504 0.077
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.029 0.1031 0.6564
Schistosoma mansoni inositol monophosphatase 0.0074 0.0139 0.0134
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0095 0.0222 0.0348
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.0057 0.0066 0.0068
Trichomonas vaginalis thymidylate kinase, putative 0.029 0.1031 0.1569
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1401 0.5624 0.5615
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0064 0.0098 0.0078
Loa Loa (eye worm) hypothetical protein 0.0065 0.0101 0.0111
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0236 0.0806 0.1259
Toxoplasma gondii exonuclease III APE 0.0095 0.0222 0.0348
Brugia malayi carbohydrate phosphorylase 0.0111 0.0291 0.0425
Echinococcus multilocularis Zinc finger, PHD finger 0.0274 0.0963 0.0945
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0236 0.0806 0.1259
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0361 0.0357
Brugia malayi hypothetical protein 0.0954 0.3775 0.6057
Echinococcus multilocularis Protein lozenge 0.0057 0.0067 0.0048
Brugia malayi thymidylate kinase 0.029 0.1031 0.1621
Loa Loa (eye worm) hypothetical protein 0.007 0.0121 0.0133
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0107 0.0272 0.0391
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0107 0.0272 0.0436
Trichomonas vaginalis ap endonuclease, putative 0.0095 0.0222 0.0255
Schistosoma mansoni glycogen phosphorylase 0.0111 0.0291 0.0286
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1544 0.6215 1
Mycobacterium ulcerans cytidine deaminase 0.0057 0.0066 0.0064
Schistosoma mansoni hypothetical protein 0.0108 0.0278 0.0274
Entamoeba histolytica hypothetical protein 0.0108 0.0278 0.0402
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0361 0.0357
Plasmodium vivax ataxin-2 like protein, putative 0.0102 0.0252 0.04
Onchocerca volvulus Matrilysin homolog 0.0057 0.0068 0.0017
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0065 0.0101 0.0082
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0163 0.0504 0.0852
Giardia lamblia Farnesyl diphosphate synthase 0.1401 0.5624 1
Giardia lamblia Glycogen phosphorylase 0.0111 0.0291 0.0405
Loa Loa (eye worm) hypothetical protein 0.0068 0.0114 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0098 0.0052
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.0381 0.0362
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0274 0.0963 0.1509
Schistosoma mansoni thyroid hormone receptor 0.0169 0.0531 0.0526
Echinococcus granulosus carbonic anhydrase II 0.0236 0.0806 0.0788
Echinococcus granulosus tar DNA binding protein 0.0128 0.0361 0.0342
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0486 0.1841 0.324
Echinococcus multilocularis isocitrate dehydrogenase 0.0047 0.0028 0.0008
Loa Loa (eye worm) phosphatidylinositol 3 0.0107 0.0272 0.0298
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0412 0.1536 0.1519
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.1218 0.4869 0.7811
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0163 0.0504 0.0852
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0064 0.0098 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0234 0.0274
Echinococcus granulosus thymidine kinase 0.1223 0.4889 0.4879
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Leishmania major farnesyl pyrophosphate synthase 0.1401 0.5624 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.033 0.0362
Loa Loa (eye worm) hypothetical protein 0.0071 0.0124 0.0136
Loa Loa (eye worm) hypothetical protein 0.0135 0.0391 0.0429
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0274 0.0963 0.1671
Onchocerca volvulus 0.0195 0.0636 0.346
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0412 0.1536 0.2695
Brugia malayi Pre-SET motif family protein 0.0208 0.0693 0.1075
Schistosoma mansoni carbonic anhydrase-related 0.0141 0.0413 0.0408
Echinococcus multilocularis glycogen phosphorylase 0.0111 0.0291 0.0272
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.0252 0.0362
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0274 0.0963 0.1671
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1401 0.5624 0.9044
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.0121 0.0151
Echinococcus multilocularis carbonic anhydrase 0.0141 0.0413 0.0394
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0095 0.0222 0.0282
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0097 0.0234 0.0369
Brugia malayi cytidine deaminase, identical 0.0057 0.0066 0.0061
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0141 0.0413 0.0452
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0412 0.1536 0.1519
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.007 0.0121 0.0101
Plasmodium vivax thymidylate kinase, putative 0.029 0.1031 0.1792
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0245 0.0269
Leishmania major phosphatidylinositol 3-kinase, putative 0.0274 0.0963 0.1671
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.013 0.037 0.0365
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.0098 0.0125
Onchocerca volvulus 0.0135 0.0391 0.1976
Loa Loa (eye worm) hypothetical protein 0.0047 0.0026 0.0028
Loa Loa (eye worm) isocitrate dehydrogenase 0.0047 0.0028 0.003
Giardia lamblia GTOR 0.0107 0.0272 0.0371
Toxoplasma gondii FATC domain-containing protein 0.007 0.0121 0.0167
Onchocerca volvulus 0.0163 0.0504 0.2663
Loa Loa (eye worm) hypothetical protein 0.0133 0.0381 0.0418
Echinococcus granulosus intermediate filament protein 0.0135 0.0391 0.0372
Brugia malayi Hemopexin family protein 0.0081 0.0167 0.0226
Echinococcus granulosus Na+ dependent nucleoside transporter 0.0363 0.1331 0.1314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0234 0.0274
Echinococcus multilocularis survival motor neuron protein 1 0.0954 0.3775 0.3763
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0064 0.0098 0.0052
Echinococcus granulosus lamin 0.0135 0.0391 0.0372
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0811 0.3187 0.5106
Loa Loa (eye worm) phosphatidylinositol 3 0.0421 0.1574 0.1726
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0073 0.0131 0.0144
Echinococcus granulosus carbonic anhydrase 0.0141 0.0413 0.0394
Echinococcus multilocularis carbonic anhydrase 0.0141 0.0413 0.0394
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0412 0.1536 0.1519
Echinococcus multilocularis thyroid hormone receptor alpha 0.0169 0.0531 0.0512
Brugia malayi thymidylate synthase 0.0163 0.0504 0.077
Echinococcus multilocularis glycogen phosphorylase 0.0111 0.0291 0.0272
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0077 0.0148 0.0195
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0064 0.0098 0.0052
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0064 0.0098 0.011
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1401 0.5624 0.9044
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0077 0.0148 0.0215
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.0252 0.04
Trypanosoma cruzi cytidine deaminase-like protein 0.0057 0.0066 0.0061
Echinococcus multilocularis tar DNA binding protein 0.0128 0.0361 0.0342
Echinococcus multilocularis thymidylate synthase 0.0163 0.0504 0.0486
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0236 0.0806 0.0802
Schistosoma mansoni hypothetical protein 0.0195 0.0636 0.0631
Echinococcus granulosus cytidine deaminase 0.0057 0.0066 0.0046
Giardia lamblia Thymidine kinase 0.1019 0.4044 0.7158
Schistosoma mansoni carbonic anhydrase-related 0.0141 0.0413 0.0408
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0047 0.0028 0.0008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.0121 0.0151
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0095 0.0222 0.0203
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0107 0.0272 0.0436
Leishmania major phosphatidylinositol 3-kinase, putative 0.0077 0.0148 0.0215
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1598 0.644 0.6432
Loa Loa (eye worm) hypothetical protein 0.0071 0.0125 0.0137
Brugia malayi cytoplasmic intermediate filament protein 0.0073 0.0131 0.0167
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0163 0.0504 0.0852
Echinococcus multilocularis carbonic anhydrase II 0.0236 0.0806 0.0788
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0135 0.0391 0.0429
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0077 0.0148 0.0195
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.0363 0.1331 0.1314
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0028 0.0008
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0573 0.2202 0.3514
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0095 0.0222 0.0315
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1544 0.6215 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.0777 0.134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0234 0.0274
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0107 0.0272 0.0253
Entamoeba histolytica hypothetical protein 0.1331 0.5337 0.8581
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1401 0.5624 0.5622
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0486 0.1841 0.1837
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.0252 0.0362
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0495 0.1879 0.3308
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0114 0.014
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0281 0.0995 0.0977
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.0139 0.0119
Loa Loa (eye worm) thymidylate kinase 0.029 0.1031 0.113
Loa Loa (eye worm) matrixin family protein 0.0211 0.0706 0.0774
Loa Loa (eye worm) polyprenyl synthetase 0.0412 0.1536 0.1684
Brugia malayi hypothetical protein 0.0108 0.0278 0.0405
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.029 0.1031 0.1792
Leishmania major hypothetical protein, unknown function 0.0064 0.0098 0.0125
Entamoeba histolytica thymidine kinase, putative 0.1019 0.4044 0.649
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0141 0.0413 0.0622
Trypanosoma brucei cytidine deaminase 0.0057 0.0066 0.0068
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0274 0.0963 0.0945
Entamoeba histolytica hypothetical protein 0.0108 0.0278 0.0402
Echinococcus granulosus thymidine kinase 0.1223 0.4889 0.4879
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.04 0.0396
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.1006 0.3991 0.7063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0098 0.0052
Echinococcus granulosus carbonic anhydrase 0.0141 0.0413 0.0394
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0272 0.0336
Entamoeba histolytica hypothetical protein 0.0064 0.0098 0.011
Schistosoma mansoni bromodomain containing protein 0.0063 0.0093 0.0089
Schistosoma mansoni glycogen phosphorylase 0.0048 0.003 0.0025
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.0252 0.04
Schistosoma mansoni trans-prenyltransferase 0.0412 0.1536 0.1532
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0148 0.0134
Trypanosoma cruzi polyprenyl synthase, putative 0.0573 0.2202 0.3514
Trypanosoma cruzi thymidylate kinase, putative 0.029 0.1031 0.1621
Brugia malayi MH2 domain containing protein 0.0121 0.033 0.0488
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0148 0.0195
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.04 0.0381
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.007 0.012 0.0165
Trypanosoma cruzi polyprenyl synthase, putative 0.0573 0.2202 0.3514
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0064 0.0098 0.0078
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0274 0.0963 0.0945
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0486 0.1841 0.2928
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0495 0.1879 0.3305
Echinococcus granulosus thymidylate kinase 0.029 0.1031 0.1013
Entamoeba histolytica hypothetical protein 0.0064 0.0098 0.011
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0077 0.0148 0.0129
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0163 0.0504 0.0852
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0486 0.1841 0.2887
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0274 0.0963 0.1512
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0245 0.0291
Leishmania major hypothetical protein, conserved 0.0114 0.0302 0.049
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0412 0.1536 1
Trichomonas vaginalis thymidine kinase, putative 0.1019 0.4044 0.647
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0234 0.0274
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0197 0.0214
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0412 0.1536 0.2435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0095 0.0222 0.0315
Plasmodium vivax hypothetical protein, conserved 0.0064 0.0098 0.0125
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0064 0.0098 0.0078
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0095 0.0222 0.0348
Onchocerca volvulus 0.0237 0.0812 0.453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0272 0.0336
Leishmania major phosphatidylinositol 4-kinase, putative 0.0064 0.0098 0.0125
Toxoplasma gondii target of rapamycin (TOR), putative 0.0095 0.0224 0.0351
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0064 0.0098 0.0113
Loa Loa (eye worm) hypothetical protein 0.007 0.012 0.0132
Entamoeba histolytica glycogen phosphorylase, putative 0.0111 0.0291 0.0422
Schistosoma mansoni thymidylate kinase 0.029 0.1031 0.1027
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0412 0.1536 0.2437
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0097 0.0234 0.0369
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0048 0.003 0.0004
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.029 0.1031 0.5126
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1401 0.5624 0.5615
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.0823 0.0902
Echinococcus granulosus thymidylate synthase 0.0163 0.0504 0.0486
Schistosoma mansoni carbonic anhydrase-related 0.0141 0.0413 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0197 0.0214
Onchocerca volvulus 0.0064 0.0098 0.0196
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0107 0.0272 0.0436
Treponema pallidum octaprenyl-diphosphate synthase 0.0573 0.2202 1
Plasmodium falciparum thymidylate kinase 0.029 0.1031 0.1792
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0064 0.0098 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0121 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.1223 0.4889 0.4879
Brugia malayi Matrixin family protein 0.0057 0.0068 0.0066
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0274 0.0963 0.1512
Giardia lamblia Deoxynucleoside kinase 0.0397 0.1474 0.2534
Loa Loa (eye worm) hypothetical protein 0.0063 0.0091 0.01
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0139 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0486 0.1841 0.2887
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1401 0.5624 1
Brugia malayi Polyprenyl synthetase family protein 0.0412 0.1536 0.2437
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0095 0.0222 0.0311
Mycobacterium ulcerans hydrolase 0.007 0.012 0.0161
Schistosoma mansoni hypothetical protein 0.0263 0.092 0.0915
Onchocerca volvulus 0.0064 0.0098 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0272 0.0336
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0064 0.0098 0.0125
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0573 0.2202 0.2187
Loa Loa (eye worm) phosphatidylinositol 3 0.0077 0.0148 0.0162
Onchocerca volvulus 0.0455 0.1713 1
Leishmania major thymidylate kinase-like protein 0.029 0.1031 0.1792
Schistosoma mansoni hypothetical protein 0.024 0.0822 0.0818
Onchocerca volvulus 0.0135 0.0391 0.1976
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0079 0.0059
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0163 0.0504 0.0852
Brugia malayi Intermediate filament tail domain containing protein 0.0135 0.0391 0.0587
Loa Loa (eye worm) matrix metalloproteinase 0.0057 0.0068 0.0075
Loa Loa (eye worm) hypothetical protein 0.0141 0.0413 0.0452
Loa Loa (eye worm) phosphatidylinositol 3 0.0064 0.0098 0.0107
Leishmania major cytidine deaminase-like protein 0.0057 0.0066 0.0068
Echinococcus multilocularis serine protein kinase ATM 0.007 0.0121 0.0101
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0064 0.0098 0.0125
Entamoeba histolytica hypothetical protein 0.007 0.0121 0.0147
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0599 0.2309 0.3685
Brugia malayi Inositol-1 0.0074 0.0139 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0148 0.0134
Trichomonas vaginalis ap endonuclease, putative 0.0095 0.0222 0.0255
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0139 0.0179
Loa Loa (eye worm) hypothetical protein 0.0063 0.0091 0.01
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0811 0.3187 0.3173
Loa Loa (eye worm) inositol-1 0.0074 0.0139 0.0152
Loa Loa (eye worm) hypothetical protein 0.0141 0.0413 0.0452
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0915 0.3617 0.5801
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0071 0.0125 0.0174
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0274 0.0963 0.1459
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0095 0.0222 0.0348
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0064 0.0098 0.0078
Echinococcus granulosus solute carrier family 28 0.0363 0.1331 0.1314
Leishmania major solanesyl-diphosphate synthase, putative 0.0412 0.1536 0.2695
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0028 0.0008
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0277 0.0976 0.1637
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.0057 0.0066 0.0068
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1401 0.5624 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0064 0.0098 0.0107
Brugia malayi TAR-binding protein 0.0128 0.0361 0.0539
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0412 0.1536 0.2437
Loa Loa (eye worm) thymidylate synthase 0.0163 0.0504 0.0553
Loa Loa (eye worm) glycogen phosphorylase 0.0111 0.0291 0.0319
Trichomonas vaginalis thymidylate kinase, putative 0.029 0.1031 0.1569
Leishmania major carbonic anhydrase-like protein 0.0236 0.0806 0.1392
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0107 0.0272 0.0395
Schistosoma mansoni hypothetical protein 0.0133 0.0381 0.0376
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0163 0.0504 0.2985
Trypanosoma cruzi thymidine kinase, putative 0.1019 0.4044 0.6491
Loa Loa (eye worm) phosphatidylinositol kinase 0.0064 0.0098 0.0107
Echinococcus granulosus glycogen phosphorylase 0.0111 0.0291 0.0272
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0486 0.1841 0.293
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0361 0.0357
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0077 0.0148 0.0215
Schistosoma mansoni ap endonuclease 0.0095 0.0222 0.0218
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.007 0.012 0.0149
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0064 0.0098 0.0113
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0064 0.0098 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0121 0.009
Loa Loa (eye worm) hypothetical protein 0.013 0.037 0.0405
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0077 0.0152 0.02
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0064 0.0098 0.0125
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0141 0.0413 0.0622
Loa Loa (eye worm) hypothetical protein 0.0057 0.0068 0.0075
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0245 0.0351
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0274 0.0963 0.1671
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.0139 0.0194
Leishmania major phosphatidylinositol kinase related protein, putative 0.0064 0.0098 0.0125
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0026 0.0006
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.0139 0.0198
Brugia malayi intermediate filament protein 0.0135 0.0391 0.0587
Schistosoma mansoni hypothetical protein 0.0141 0.0413 0.0408
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0236 0.0806 0.0802
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.0139 0.0119
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0026 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0095 0.0224 0.0258
Echinococcus multilocularis thymidine kinase 0.1223 0.4889 0.4879
Mycobacterium leprae conserved hypothetical protein 0.0064 0.0098 0.0219
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0361 0.0357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.0211 0.0236
Treponema pallidum thymidylate kinase (tmk) 0.029 0.1031 0.4083
Brugia malayi hypothetical protein 0.0455 0.1713 0.2725
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0573 0.2202 0.2414
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0274 0.0963 0.0945
Schistosoma mansoni inositol monophosphatase 0.0074 0.0139 0.0134
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.2459 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0107 0.0272 0.0267
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1544 0.6215 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0107 0.0272 0.0253
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0064 0.0098 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0148 0.0134
Trypanosoma brucei RNA helicase, putative 0.024 0.0822 0.142
Loa Loa (eye worm) matrixin family protein 0.0127 0.0357 0.0391
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0077 0.0148 0.0144
Trypanosoma brucei thymidine kinase 0.1019 0.4044 0.7177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0197 0.0214
Mycobacterium ulcerans thymidylate synthase 0.0163 0.0504 0.0848
Giardia lamblia CDC8 0.029 0.1031 0.1736
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1544 0.6215 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0064 0.0098 0.0125
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1544 0.6215 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0064 0.0098 0.0113
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0495 0.1879 0.3308
Trypanosoma cruzi thymidine kinase, putative 0.1019 0.4044 0.6491
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.0139 0.0119
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0412 0.1536 0.8029
Echinococcus granulosus Glycosyl transferase family 35 0.0111 0.0291 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0196 0.0212
Toxoplasma gondii LsmAD domain-containing protein 0.0102 0.0252 0.04
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0274 0.0963 0.0959
Schistosoma mansoni ap endonuclease 0.0095 0.0222 0.0218
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0095 0.0222 0.0348
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1331 0.5337 0.8581
Mycobacterium tuberculosis Hypothetical protein 0.0077 0.0152 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0148 0.0134
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0412 0.1536 0.1519
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0107 0.0272 0.0436
Schistosoma mansoni thymidine kinase 0.1223 0.4889 0.4887
Giardia lamblia Phosphatidylinositol 4-kinase 0.0064 0.0098 0.0058
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1544 0.6215 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0026 0.0021
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0278 0.0259
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0412 0.1536 0.2435
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0095 0.0222 0.0344
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0163 0.0504 0.0852
Leishmania major hypothetical protein, conserved 0.0064 0.0098 0.0125
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.0361 0.0396
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0274 0.0963 0.0959
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.1479 0.5948 0.9569
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.04 0.0381
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0412 0.1536 0.2437
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0064 0.0098 0.0093
Leishmania major hypothetical protein, conserved 0.0102 0.0252 0.04
Schistosoma mansoni fkbp-rapamycin associated protein 0.007 0.0121 0.0116
Trichomonas vaginalis set domain proteins, putative 0.0237 0.0812 0.1214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0186 0.0196
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0107 0.0272 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0152 0.014
Leishmania major phosphatidylinositol kinase, putative 0.0064 0.0098 0.0125
Loa Loa (eye worm) hypothetical protein 0.0102 0.0252 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0097 0.0234 0.0274
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0064 0.0098 0.0113
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0047 0.0028 0.0023
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0064 0.0098 0.0125
Onchocerca volvulus Matrix metalloproteinase homolog 0.0127 0.0357 0.1769

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 608 nM Inhibitory activity against HIV-1 reverse transcriptase ChEMBL. 10576692
IC50 (binding) = 608 nM Inhibitory activity against HIV-1 reverse transcriptase ChEMBL. 15546736
IC50 (binding) = 608 nM Inhibitory activity against HIV-1 reverse transcriptase ChEMBL. 10576692
IC50 (binding) = 608 nM Inhibitory activity against HIV-1 reverse transcriptase ChEMBL. 15546736
IC90 (binding) = 9.02 nM Inhibitory activity against HIV-1 reverse transcriptase ChEMBL. 10576692
IC90 (binding) = 9.02 nM Inhibitory activity against HIV-1 reverse transcriptase ChEMBL. 10576692

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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