Detailed information for compound 1817730

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 456.492 | Formula: C23H28N4O6
  • H donors: 6 H acceptors: 7 LogP: 2.37 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)CC[C@@H](C(=O)O)NC(=O)c1ccc(cc1)CCC1CCNc2c(C1)c(O)nc(c2)N
  • InChi: 1S/C23H28N4O6/c24-19-12-18-16(22(31)27-19)11-14(9-10-25-18)2-1-13-3-5-15(6-4-13)21(30)26-17(23(32)33)7-8-20(28)29/h3-6,12,14,17,25H,1-2,7-11H2,(H,26,30)(H,28,29)(H,32,33)(H3,24,27,31)/t14?,17-/m0/s1
  • InChiKey: OYZJAEQJHDLZOE-JRZJBTRGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus phosphoribosylglycinamide formyltransferase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium leprae PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT Get druggable targets OG5_126894 All targets in OG5_126894
Onchocerca volvulus Get druggable targets OG5_126894 All targets in OG5_126894
Mycobacterium ulcerans phosphoribosylamine--glycine ligase Get druggable targets OG5_126894 All targets in OG5_126894
Mycobacterium ulcerans phosphoribosylaminoimidazole synthetase Get druggable targets OG5_126894 All targets in OG5_126894
Candida albicans N terminus of ADE5,7 bifunctional ligase Get druggable targets OG5_126894 All targets in OG5_126894
Wolbachia endosymbiont of Brugia malayi phosphoribosylaminoimidazole synthetase Get druggable targets OG5_126894 All targets in OG5_126894
Candida albicans ADE5,7 bifunctional ligase Get druggable targets OG5_126894 All targets in OG5_126894
Candida albicans purine biosynthesis Get druggable targets OG5_126894 All targets in OG5_126894
Wolbachia endosymbiont of Brugia malayi phosphoribosylamine--glycine ligase Get druggable targets OG5_126894 All targets in OG5_126894
Mycobacterium leprae PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE) Get druggable targets OG5_126894 All targets in OG5_126894
Mycobacterium tuberculosis Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) Get druggable targets OG5_126894 All targets in OG5_126894
Mycobacterium tuberculosis Probable phosphoribosylamine--glycine ligase PurD (GARS) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synt Get druggable targets OG5_126894 All targets in OG5_126894
Onchocerca volvulus Get druggable targets OG5_126894 All targets in OG5_126894
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0651 0.0651
Plasmodium falciparum glutathione reductase 0.0019 0.0167 0.2803
Brugia malayi PHD-finger family protein 0.0006 0.0012 0.0012
Entamoeba histolytica disulphide oxidoreductase, putative 0.0005 0 0.0009
Schistosoma mansoni lamin 0.003 0.0303 0.0302
Echinococcus granulosus bloom syndrome protein 0.0025 0.0236 0.0236
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.003 0.003
Echinococcus multilocularis neuropeptides capa receptor 0.0059 0.0651 0.0651
Schistosoma mansoni alpha-1 adrenergic receptor 0.0059 0.0651 0.0651
Echinococcus granulosus lamin 0.003 0.0303 0.0302
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0008 0.0038 0.0038
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0005 0 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0651 0.0651
Brugia malayi acetyltransferase, GNAT family protein 0.0166 0.195 0.1949
Echinococcus multilocularis orexin receptor type 2 0.0059 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Mycobacterium leprae PROBABLE THIAMINE-MONOPHOSPHATE KINASE THIL (THIAMINE-PHOSPHATE KINASE) 0.0008 0.0037 0.0037
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0138 0.1604 0.1604
Loa Loa (eye worm) histone methyltransferase 0.001 0.0063 0.0152
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0453 0.9398
Treponema pallidum NADH oxidase 0.0019 0.0167 1
Schistosoma mansoni lamin 0.003 0.0303 0.0302
Brugia malayi MAP kinase sur-1 0.0059 0.0647 0.0646
Brugia malayi putative neuropeptide receptor 0.0059 0.0651 0.0651
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0008 0.0038 0.0038
Schistosoma mansoni intermediate filament proteins 0.003 0.0303 0.0302
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0453 0.7001
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0059 0.0651 0.1574
Schistosoma mansoni adenoreceptor 0.0059 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0006 0.0012 0.0028
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0782 0.0782
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0008 0.0038 0.0038
Schistosoma mansoni cpg binding protein 0.0033 0.0339 0.0338
Brugia malayi GnHR receptor homolog 0.0059 0.0651 0.0651
Brugia malayi CXXC zinc finger family protein 0.0033 0.0339 0.0338
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0167 0.2808
Treponema pallidum ATP-dependent DNA helicase 0.0005 0.0002 0.0117
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0059 0.0651 0.0651
Onchocerca volvulus 0.0059 0.0651 0.0651
Echinococcus multilocularis neuropeptide FF receptor 2 0.0059 0.0651 0.0651
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0167 0.0167
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0651 0.0651
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0062 0.0062
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0167 0.0167
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0008 0.0038 0.0038
Onchocerca volvulus 0.0059 0.0651 0.0651
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0453 0.7001
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0006 0.0012 0.0012
Schistosoma mansoni growth hormone secretagogue receptor 0.0059 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0008 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Plasmodium falciparum selenide water dikinase, putative 0.0013 0.0102 0.1709
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0059 0.0651 0.0651
Brugia malayi Dopamine receptor protein 1 0.0059 0.0651 0.0651
Brugia malayi Dopamine receptor 0.0059 0.0651 0.0651
Echinococcus granulosus neuropeptide receptor A26 0.0059 0.0651 0.0651
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0647 0.8267
Schistosoma mansoni opsin-like receptor 0.0059 0.0651 0.0651
Schistosoma mansoni cpg binding protein 0.0035 0.0361 0.0361
Brugia malayi Cytochrome P450 family protein 0.0008 0.0038 0.0038
Loa Loa (eye worm) CYP4Cod1 0.0008 0.0038 0.0091
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0647 0.0646
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0782 1
Trypanosoma cruzi cytochrome P450, putative 0.0008 0.0038 0.0585
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0167 0.2138
Mycobacterium tuberculosis Probable dehydrogenase 0.0124 0.1437 0.1437
Mycobacterium leprae PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE II PURL (FGAM SYNTHASE II) 0.0013 0.0102 0.0102
Schistosoma mansoni opsin-like receptor 0.0059 0.0651 0.0651
Brugia malayi neuropeptide F receptor 0.0059 0.0651 0.0651
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0059 0.0651 0.0651
Schistosoma mansoni cpg binding protein 0.0035 0.0361 0.0361
Schistosoma mansoni neuropeptide F-like receptor 0.0059 0.0651 0.0651
Echinococcus multilocularis lamin dm0 0.003 0.0303 0.0302
Echinococcus granulosus histone acetyltransferase KAT2B 0.0162 0.1893 0.1893
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0651 0.0651
Schistosoma mansoni bromodomain containing protein 0.0006 0.0012 0.0012
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0647 0.0646
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0059 0.0651 0.0651
Echinococcus granulosus neuropeptide Y receptor 0.0059 0.0651 0.0651
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0059 0.0651 0.0651
Schistosoma mansoni neuropeptide F-like receptor 0.0059 0.0651 0.0651
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0008 0.0038 0.0038
Wolbachia endosymbiont of Brugia malayi phosphoribosylformylglycinamidine synthase domain-containing protein 0.0013 0.0102 0.0483
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0596 1
Echinococcus granulosus orexin receptor type 2 0.0059 0.0651 0.0651
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0651 0.0651
Echinococcus granulosus neuropeptide FF receptor 2 0.0059 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.001 0.0062 0.015
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0647 0.8267
Leishmania major cytochrome p450-like protein 0.0008 0.0038 0.0483
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0059 0.0651 0.0651
Echinococcus multilocularis G protein coupled receptor 139 0.0059 0.0651 0.0651
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0008 0.0038 0.0038
Brugia malayi glutathione reductase 0.0054 0.0596 0.0596
Echinococcus granulosus neuropeptide Y receptor 0.0059 0.0651 0.0651
Echinococcus granulosus lamin dm0 0.003 0.0303 0.0302
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Onchocerca volvulus 0.004 0.0419 0.0419
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0651 0.0651
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0008 0.0038 0.0038
Onchocerca volvulus 0.0059 0.0651 0.0651
Schistosoma mansoni selinide water dikinase 0.0013 0.0102 0.0102
Echinococcus multilocularis 0.0013 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.003 0.003
Trichomonas vaginalis peptide N-glycanase, putative 0.0833 1 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0647 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.003 0.003
Schistosoma mansoni DNA helicase recq1 0.001 0.0062 0.0062
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0167 0.2586
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.003 0.003
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0782 0.0782
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0008 0.0038 0.0038
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0453 0.0452
Brugia malayi Dopamine receptor protein 2 0.0059 0.0651 0.0651
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0008 0.0038 0.0038
Loa Loa (eye worm) selenium donor protein 0.0013 0.0102 0.0246
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0008 0.0038 0.0038
Mycobacterium ulcerans transglutaminase family protein 0.0833 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0059 0.0651 0.0651
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0453 0.0452
Brugia malayi hypothetical protein 0.0059 0.0651 0.0651
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0098 0.0098
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0062 0.0062
Echinococcus granulosus neuropeptide s receptor 0.0059 0.0651 0.0651
Mycobacterium tuberculosis Conserved protein 0.0833 1 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0166 0.195 0.1949
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0167 0.2586
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0008 0.0038 0.0585
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0647 0.1562
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0008 0.0038 0.0585
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0651 0.0651
Echinococcus granulosus zinc finger protein 0.0006 0.0012 0.0012
Schistosoma mansoni DNA helicase recq5 0.001 0.0062 0.0062
Onchocerca volvulus 0.0005 0.0005 0.0004
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0098 0.1252
Trypanosoma cruzi selenophosphate synthetase, putative 0.0013 0.0102 0.1576
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0059 0.0651 0.0651
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0167 0.0167
Echinococcus granulosus cytochrome P450 2K1 0.0008 0.0038 0.0038
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0303 0.0302
Brugia malayi selenium donor protein 0.0013 0.0102 0.0102
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0167 0.2586
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0008 0.0038 0.0038
Loa Loa (eye worm) glutathione reductase 0.0054 0.0596 0.1441
Schistosoma mansoni biogenic amine receptor 0.0059 0.0651 0.0651
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0236 0.0236
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0059 0.0651 0.1574
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0039 0.0039
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0059 0.0651 0.1574
Echinococcus granulosus g-protein coupled receptor 0.0059 0.0651 0.0651
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0348 0.4136 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0782 0.0782
Echinococcus granulosus selenide water dikinase 0.0013 0.0102 0.0102
Schistosoma mansoni amine GPCR 0.0059 0.0651 0.0651
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0167 0.2138
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.003 0.003
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0062 0.0062
Schistosoma mansoni methionyl-tRNA formyltransferase 0.0007 0.0019 0.0018
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0062 0.0062
Plasmodium falciparum glutathione reductase 0.0054 0.0596 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0348 0.4136 0.4136
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0098 0.204
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0134 0.0134
Brugia malayi Thioredoxin reductase 0.0054 0.0596 0.0596
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0059 0.0651 0.0651
Loa Loa (eye worm) G-protein coupled receptor 0.0059 0.0651 0.1574
Echinococcus granulosus dnaJ subfamily B 0.047 0.5617 0.5617
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0107 0.0107
Echinococcus multilocularis neuropeptide receptor 0.0059 0.0651 0.0651
Brugia malayi AKH receptor 0.0059 0.0651 0.0651
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0038 0.0091
Leishmania major cytochrome p450-like protein 0.0008 0.0038 0.0483
Trypanosoma cruzi methionyl-tRNA formyltransferase, putative 0.0007 0.0019 0.0285
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Brugia malayi Bromodomain containing protein 0.0006 0.0012 0.0012
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0124 0.1437 0.1437
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0008 0.0038 0.0038
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0008 0.0038 0.0038
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0008 0.0038 0.0585
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0008 0.0038 0.0038
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0167 0.2138
Plasmodium falciparum thioredoxin reductase 0.0019 0.0167 0.2803
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0596 0.0596
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0167 0.2586
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0008 0.0038 0.0038
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0008 0.0038 0.0038
Mycobacterium tuberculosis Hypothetical protein 0.0833 1 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0008 0.0038 0.0038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0167 0.2586
Echinococcus multilocularis musashi 0.003 0.0303 0.0302
Brugia malayi hypothetical protein 0.0059 0.0651 0.0651
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0167 0.2586
Mycobacterium leprae Conserved hypothetical protein 0.0833 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0059 0.0651 0.0651
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0008 0.0038 0.0038
Mycobacterium ulcerans phosphoribosylamine--glycine ligase 0.018 0.211 0.211
Loa Loa (eye worm) neuropeptide F receptor 0.0059 0.0651 0.1574
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Mycobacterium ulcerans hypothetical protein 0.0833 1 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0348 0.4136 1
Onchocerca volvulus 0.0059 0.0651 0.0651
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0005 0 0.0009
Toxoplasma gondii thioredoxin reductase 0.0054 0.0596 0.7625
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0167 0.2803
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0059 0.0651 0.0651
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0059 0.0651 0.0651
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0062 0.0792
Echinococcus granulosus serotonin receptor 0.0059 0.0651 0.0651
Echinococcus granulosus Transglutaminase 0.0833 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0348 0.4136 0.4136
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0482 0.8078
Loa Loa (eye worm) TYRA-2 protein 0.0059 0.0651 0.1574
Loa Loa (eye worm) acetyltransferase 0.0166 0.195 0.4713
Mycobacterium leprae putative cytochrome p450 0.0008 0.0038 0.0038
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0039 0.0039
Echinococcus multilocularis serotonin receptor 0.0059 0.0651 0.0651
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0059 0.0651 0.0651
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0059 0.0651 0.0651
Schistosoma mansoni hypothetical protein 0.0008 0.0038 0.0038
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0167 0.0167
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0006 0.0012 0.0012
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0167 0.0167
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0647 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Leishmania major cytochrome p450-like protein 0.0008 0.0038 0.0483
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0453 0.0452
Leishmania major methionyl-tRNA formyltransferase, putative 0.0007 0.0019 0.0235
Trypanosoma brucei trypanothione reductase 0.0054 0.0596 0.9223
Loa Loa (eye worm) hypothetical protein 0.003 0.0303 0.0731
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0059 0.0651 0.0651
Schistosoma mansoni amine GPCR 0.0059 0.0651 0.0651
Echinococcus granulosus sex peptide receptor 0.0059 0.0651 0.0651
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0059 0.0651 0.0651
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0167 0.2138
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Mycobacterium tuberculosis Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) 0.004 0.0419 0.0419
Brugia malayi hypothetical protein 0.0059 0.0651 0.0651
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0647 1
Brugia malayi G-protein coupled receptor 0.0059 0.0651 0.0651
Echinococcus granulosus fmrfamide receptor 0.0059 0.0651 0.0651
Loa Loa (eye worm) RecQ helicase 0.0025 0.0236 0.057
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0008 0.0038 0.0038
Schistosoma mansoni amine GPCR 0.0059 0.0651 0.0651
Echinococcus granulosus allatostatin A receptor 0.0059 0.0651 0.0651
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0039 0.0039
Mycobacterium ulcerans hypothetical protein 0.0833 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0059 0.0651 0.0651
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0059 0.0651 0.0651
Echinococcus multilocularis zinc finger protein 0.0006 0.0012 0.0012
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0005 0.0002 0.003
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0107 0.0107
Echinococcus multilocularis lamin 0.003 0.0303 0.0302
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0059 0.0651 0.0651
Mycobacterium ulcerans phosphoribosylformylglycinamidine synthase II 0.0013 0.0102 0.0102
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0008 0.0038 0.0038
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0453 0.0452
Toxoplasma gondii selenide, water dikinase 0.0018 0.0163 0.2076
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0167 0.2138
Echinococcus multilocularis somatostatin receptor 0.0059 0.0651 0.0651
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0167 0.0167
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0596 0.1441
Schistosoma mansoni hypothetical protein 0.0059 0.0651 0.0651
Brugia malayi G-protein coupled receptor 0.0059 0.0651 0.0651
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0167 0.2803
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.003 0.003
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0038 0.0091
Wolbachia endosymbiont of Brugia malayi folate-dependent phosphoribosylglycinamide formyltransferase PurN 0.0007 0.0019 0.0087
Mycobacterium tuberculosis Probable reductase 0.0124 0.1437 0.1437
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0059 0.0651 0.0651
Onchocerca volvulus 0.0059 0.0651 0.0651
Brugia malayi RE15519p 0.0059 0.0651 0.0651
Echinococcus multilocularis G-protein coupled receptor, putative 0.0059 0.0651 0.0651
Brugia malayi hypothetical protein 0.0059 0.0651 0.0651
Mycobacterium tuberculosis Phosphoribosylformylglycinamidine synthase II PurL (FGAM synthase II) 0.0013 0.0102 0.0102
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0008 0.0038 0.0038
Schistosoma mansoni biogenic amine (5HT) receptor 0.0059 0.0651 0.0651
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0647 0.0646
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0651 0.0651
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0059 0.0651 0.0651
Brugia malayi Serotonin receptor 0.0059 0.0651 0.0651
Echinococcus multilocularis neuropeptide Y receptor 0.0059 0.0651 0.0651
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.003 0.003
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0115 0.0115
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0059 0.0651 0.0651
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0647 0.0646
Loa Loa (eye worm) neuropeptide F receptor 0.0059 0.0651 0.1574
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0647 0.0646
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0453 0.7001
Plasmodium vivax ferrodoxin reductase, putative 0.0005 0 0.0007
Schistosoma mansoni biogenic amine receptor 0.0059 0.0651 0.0651
Echinococcus multilocularis serotonin receptor 0.0059 0.0651 0.0651
Mycobacterium ulcerans thiamine monophosphate kinase 0.0008 0.0037 0.0037
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0059 0.0651 0.0651
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0167 0.2586
Onchocerca volvulus Neuropeptide F receptor homolog 0.0059 0.0651 0.0651
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0059 0.0651 0.1574
Onchocerca volvulus 0.0059 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0029 0.0296 0.0715
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0005
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0005 0 0.0007
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0453 0.0452
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0008 0.0038 0.0585
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0063 0.0063
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0647 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0005 0.0002 0.003
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0167 0.2586
Brugia malayi G protein-coupled receptor F59B2.13 0.0059 0.0651 0.0651
Mycobacterium tuberculosis Probable formyltetrahydrofolate deformylase PurU (formyl-FH(4) hydrolase) 0.0007 0.0019 0.0018
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0167 0.0792
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0008 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Brugia malayi hypothetical protein 0.0059 0.0651 0.0651
Echinococcus multilocularis neuropeptide receptor A26 0.0059 0.0651 0.0651
Trypanosoma brucei methionyl-tRNA formyltransferase 0.0007 0.0019 0.0285
Schistosoma mansoni hypothetical protein 0.047 0.5617 0.5617
Schistosoma mansoni amine GPCR 0.0059 0.0651 0.0651
Echinococcus granulosus alpha 1A adrenergic receptor 0.0059 0.0651 0.0651
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0059 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Echinococcus multilocularis neuropeptide s receptor 0.0059 0.0651 0.0651
Onchocerca volvulus 0.0059 0.0651 0.0651
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0138 0.1604 0.1604
Trypanosoma brucei Selenophosphate synthetase 2 0.0013 0.0102 0.1576
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0531 0.8905
Mycobacterium tuberculosis Conserved hypothetical protein 0.0007 0.0019 0.0018
Schistosoma mansoni hypothetical protein 0.0059 0.0651 0.0651
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0167 0.0167
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0531 0.0531
Trypanosoma brucei protein kinase, putative 0.0059 0.0647 1
Echinococcus granulosus neuropeptide receptor 0.0059 0.0651 0.0651
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0651 0.0651
Schistosoma mansoni amine GPCR 0.0059 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0014 0.0108 0.0261
Echinococcus multilocularis fmrfamide receptor 0.0059 0.0651 0.0651
Echinococcus granulosus neuropeptides capa receptor 0.0059 0.0651 0.0651
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0647 0.0646
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0453 0.1094
Brugia malayi hypothetical protein 0.0059 0.0651 0.0651
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0744 0.9521
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0647 0.0646
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0124 0.1437 0.1437
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0059 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0059 0.0651 0.0651
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0453 0.0452
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0596 0.0596
Echinococcus multilocularis neuropeptide Y receptor 0.0059 0.0651 0.0651
Entamoeba histolytica recQ family DNA helicase 0.0005 0.0002 0.0049
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0008 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.003 0.003
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0062 0.0062
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0167 0.2586
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0651 0.0651
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.003 0.003
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0008 0.0038 0.0038
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0782 0.0782
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.02 0.3353
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0008 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0008 0.0038 0.0038
Echinococcus multilocularis cpg binding protein 0.0035 0.0361 0.0361
Toxoplasma gondii cytochrome p450 superfamily protein 0.0008 0.0038 0.0483
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0098 0.1515
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Onchocerca volvulus 0.0059 0.0651 0.0651
Brugia malayi hypothetical protein 0.0059 0.0651 0.0651
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0005 0 0.0009
Brugia malayi follicle stimulating hormone receptor 0.0059 0.0651 0.0651
Mycobacterium ulcerans phosphoribosylglycinamide formyltransferase 0.0007 0.0019 0.0018
Schistosoma mansoni hypothetical protein 0.0059 0.0651 0.0651
Onchocerca volvulus 0.0059 0.0651 0.0651
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0166 0.195 0.1949
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0782 0.0782
Loa Loa (eye worm) hypothetical protein 0.0006 0.0012 0.0028
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Schistosoma mansoni opsin-like receptor 0.0059 0.0651 0.0651
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0059 0.0651 0.0651
Schistosoma mansoni myosin xvIII 0.0059 0.0651 0.0651
Onchocerca volvulus 0.0032 0.0322 0.0321
Onchocerca volvulus 0.0059 0.0651 0.0651
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0059 0.0651 0.0651
Echinococcus granulosus tm gpcr rhodopsin 0.0059 0.0651 0.0651
Echinococcus granulosus peptide allatostatin:somatostatin 0.0059 0.0651 0.0651
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0651 0.0651
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0782 0.0782
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0008 0.0038 0.0038
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0008 0.0038 0.0038
Echinococcus multilocularis 0.0008 0.0038 0.0038
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0531 0.6789
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0782 0.0782
Echinococcus multilocularis dnaJ subfamily B 0.047 0.5617 0.5617
Echinococcus granulosus neuropeptide receptor 0.0059 0.0651 0.0651
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0531 0.6789
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0596 0.9223
Echinococcus granulosus g protein coupled receptor 0.0059 0.0651 0.0651
Schistosoma mansoni biogenic amine receptor 0.0059 0.0651 0.0651
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0482 0.0481
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0167 0.2138
Mycobacterium tuberculosis Conserved hypothetical protein 0.0833 1 1
Plasmodium falciparum methionyl-tRNA formyltransferase, putative 0.0007 0.0019 0.0309
Mycobacterium leprae PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT 0.018 0.211 0.211
Echinococcus granulosus 7TM GPCR rhodopsin 0.0059 0.0651 0.0651
Loa Loa (eye worm) G-protein coupled receptor 0.0059 0.0651 0.1574
Brugia malayi G protein-coupled receptor 0.0059 0.0651 0.0651
Onchocerca volvulus 0.0059 0.0651 0.0651
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0453 0.0452
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0039 0.0039
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0124 0.1437 0.1437
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0167 0.0792
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0651 0.0651
Echinococcus granulosus biogenic amine 5HT receptor 0.0059 0.0651 0.0651
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0059 0.0651 0.1574
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0303 0.0731
Leishmania major trypanothione reductase 0.0054 0.0596 0.7625
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0453 0.0452
Entamoeba histolytica thioredoxin reductase, putative 0.0005 0 0.0009
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Brugia malayi neuropeptide F receptor 0.0059 0.0651 0.0651
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0531 0.0531
Plasmodium vivax methionyl-tRNA formyltransferase, putative 0.0007 0.0019 0.0316
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0008 0.0038 0.0483
Echinococcus multilocularis g protein coupled receptor 0.0059 0.0651 0.0651
Echinococcus granulosus tm gpcr rhodopsin 0.0059 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0098 0.1515
Onchocerca volvulus 0.003 0.0303 0.0302
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0008 0.0038 0.0038
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0782 0.0782
Brugia malayi cytochrome P450 0.0008 0.0038 0.0038
Schistosoma mansoni histamine h1 receptor 0.0059 0.0651 0.0651
Brugia malayi hypothetical protein 0.0059 0.0651 0.0651
Plasmodium falciparum thioredoxin reductase 0.0054 0.0596 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0453 0.0452
Brugia malayi ORL1-like opioid receptor 0.0059 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Brugia malayi Cytochrome P450 family protein 0.0008 0.0038 0.0038
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0059 0.0651 0.0651
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.003 0.003
Echinococcus multilocularis g protein coupled receptor 0.0059 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0172 0.2013 0.4867
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0062 0.1039
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0167 0.0167
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Plasmodium vivax glutathione reductase, putative 0.0054 0.0596 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0008 0.0038 0.0091
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0039 0.0039
Echinococcus granulosus hypothetical protein 0.0059 0.0651 0.0651
Onchocerca volvulus 0.003 0.0303 0.0302
Echinococcus granulosus g protein coupled receptor 0.0059 0.0651 0.0651
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0236 0.0236
Echinococcus multilocularis sex peptide receptor 0.0059 0.0651 0.0651
Echinococcus multilocularis Transglutaminase 0.0833 1 1
Mycobacterium leprae Conserved hypothetical protein 0.0833 1 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0453 0.0452
Schistosoma mansoni neuropeptide receptor 0.0059 0.0651 0.0651
Echinococcus granulosus 7tm_1 domain containing protein 0.0059 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0596 0.0596
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0453 0.0452
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0008 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.003 0.003
Mycobacterium tuberculosis Conserved hypothetical protein 0.0833 1 1
Echinococcus multilocularis muscleblind protein 1 0.0172 0.2013 0.2013
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0063 0.0063
Mycobacterium tuberculosis Probable phosphoribosylamine--glycine ligase PurD (GARS) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synt 0.0026 0.0257 0.0256
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0124 0.1437 0.1437
Brugia malayi Tachykinin-like peptides receptor 99D 0.0059 0.0651 0.0651
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0059 0.0651 0.0651
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0134 0.0324
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0124 0.1437 0.1437
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Onchocerca volvulus 0.0059 0.0651 0.0651
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Schistosoma mansoni neuropeptide receptor 0.0059 0.0651 0.0651
Treponema pallidum methionyl-tRNA formyltransferase (fmt) 0.0007 0.0019 0.1101
Echinococcus multilocularis g-protein coupled receptor 0.0059 0.0651 0.0651
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0453 0.5788
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0651 0.0651
Schistosoma mansoni neuropeptide f receptor 76f 0.0059 0.0651 0.0651
Mycobacterium leprae Conserved hypothetical protein 0.0008 0.0038 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0651 0.0651
Schistosoma mansoni neuropeptide receptor 0.0059 0.0651 0.0651
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0008 0.0038 0.0038
Onchocerca volvulus 0.0833 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0786 0.0785
Chlamydia trachomatis methionyl tRNAformyltransferase 0.0007 0.0019 0.1101
Brugia malayi Serotonin receptor 0.0059 0.0651 0.0651
Schistosoma mansoni hypothetical protein 0.0059 0.0651 0.0651
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0167 0.2586
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0008 0.0038 0.0038
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA formyltransferase 0.0007 0.0019 0.0087
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0008 0.0038 0.0038
Schistosoma mansoni biogenic amine (5HT) receptor 0.0059 0.0651 0.0651
Brugia malayi intermediate filament protein 0.003 0.0303 0.0302
Echinococcus granulosus somatostatin receptor 0.0059 0.0651 0.0651
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0167 1
Onchocerca volvulus 0.0059 0.0651 0.0651
Echinococcus multilocularis g protein coupled receptor 0.0059 0.0651 0.0651
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0005 0 0.0009
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Onchocerca volvulus 0.0033 0.0339 0.0338
Brugia malayi putative neuropeptide receptor NPR1 0.0059 0.0651 0.0651
Loa Loa (eye worm) intermediate filament protein 0.003 0.0303 0.0731
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0005 0 0.0009
Mycobacterium ulcerans phosphoribosylaminoimidazole synthetase 0.004 0.0419 0.0419
Brugia malayi hypothetical protein 0.0059 0.0651 0.0651
Echinococcus granulosus G protein coupled receptor 139 0.0059 0.0651 0.0651
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0172 0.2013 0.4867
Plasmodium vivax selenophosphate synthetase, putative 0.0013 0.0102 0.1715
Echinococcus granulosus muscleblind protein 0.0172 0.2013 0.2013
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0647 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0138 0.176
Echinococcus granulosus g protein coupled receptor 0.0059 0.0651 0.0651
Loa Loa (eye worm) cytochrome P450 0.0008 0.0038 0.0091
Echinococcus multilocularis fmrfamide receptor 0.0059 0.0651 0.0651
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0651 0.0651
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0167 0.0167
Echinococcus multilocularis dro:myosuppressin receptor 0.0059 0.0651 0.0651
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0062 0.0792
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0236 0.0236
Onchocerca volvulus 0.0059 0.0651 0.0651
Mycobacterium ulcerans putative transglutaminase-like protein 0.0833 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0059 0.0651 0.0651
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0339 0.0818
Onchocerca volvulus 0.0059 0.0651 0.0651
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0651 0.0651
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0647 0.8267
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0059 0.0651 0.0651
Trypanosoma cruzi methionyl-tRNA formyltransferase, putative 0.0007 0.0019 0.0285
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0138 0.1604 0.1604
Mycobacterium tuberculosis Probable oxidoreductase 0.0138 0.1604 0.1604
Loa Loa (eye worm) hypothetical protein 0.0014 0.0108 0.0261
Trichomonas vaginalis helicase, putative 0.0007 0.003 0.003
Brugia malayi hypothetical protein 0.0059 0.0651 0.0651
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0167 0.2586
Loa Loa (eye worm) hypothetical protein 0.002 0.0176 0.0425
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0647 0.0646
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0008 0.0038 0.0038
Echinococcus multilocularis neuropeptides capa receptor 0.0059 0.0651 0.0651
Mycobacterium leprae PROBABLE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM (AIRS) (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE) 0.004 0.0419 0.0419
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0062 0.0062
Echinococcus granulosus tm gpcr rhodopsin 0.0059 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Trypanosoma cruzi cytochrome P450, putative 0.0008 0.0038 0.0585
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0059 0.0651 0.0651
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0008 0.0038 0.0038
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0453 0.0452
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Schistosoma mansoni blooms syndrome DNA helicase 0.0005 0.0002 0.0002
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0062 0.0061
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0167 0.2808
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0059 0.0651 0.0651
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0008 0.0038 0.0038
Echinococcus granulosus neuropeptides capa receptor 0.0059 0.0651 0.0651
Echinococcus granulosus intermediate filament protein 0.003 0.0303 0.0302
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0008 0.0038 0.0038
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0059 0.0651 0.0651
Echinococcus granulosus cpg binding protein 0.0035 0.0361 0.0361
Brugia malayi larval opioid receptor 0.0059 0.0651 0.0651
Echinococcus multilocularis allatostatin A receptor 0.0059 0.0651 0.0651
Leishmania major selenophosphate synthetase, putative 0.0013 0.0102 0.1303
Schistosoma mansoni zinc finger protein 0.0006 0.0012 0.0012
Loa Loa (eye worm) melatonin receptor type 1A 0.0059 0.0651 0.1574
Trypanosoma brucei cytochrome P450, putative 0.0008 0.0038 0.0585
Brugia malayi Cytochrome P450 family protein 0.0008 0.0038 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0651 0.0651
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0008 0.0038 0.0038
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0115 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.003 0.003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0167 0.2586
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.014 0.2353
Mycobacterium ulcerans methionyl-tRNA formyltransferase 0.0007 0.0019 0.0018
Brugia malayi Cytochrome P450 family protein 0.0008 0.0038 0.0038
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0008 0.0038 0.0038
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0005 0.0002 0.0025
Schistosoma mansoni hypothetical protein 0.0833 1 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0453 0.0452
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0167 0.2586
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0651 0.0651
Trypanosoma cruzi selenophosphate synthetase, putative 0.0013 0.0102 0.1576
Schistosoma mansoni bromodomain containing protein 0.0006 0.0012 0.0012
Wolbachia endosymbiont of Brugia malayi phosphoribosylaminoimidazole synthetase 0.004 0.0419 0.1984
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0059 0.0651 0.0651
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0167 0.0167
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0059 0.0651 0.0651
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0647 0.0646
Echinococcus granulosus dro:myosuppressin receptor 0.0059 0.0651 0.0651
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0782 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0174 0.0173
Echinococcus multilocularis neuropeptide receptor 0.0059 0.0651 0.0651
Brugia malayi Muscleblind-like protein 0.0172 0.2013 0.2013
Brugia malayi Melatonin receptor type 1A 0.0059 0.0651 0.0651
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0647 0.0646
Schistosoma mansoni cytochrome P450 0.0008 0.0038 0.0038
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0062 0.015
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0059 0.0651 0.0651
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0008 0.0038 0.0038
Onchocerca volvulus 0.0059 0.0651 0.0651
Schistosoma mansoni neuropeptide receptor 0.0059 0.0651 0.0651
Echinococcus multilocularis muscleblind protein 0.0172 0.2013 0.2013
Loa Loa (eye worm) hypothetical protein 0.0059 0.0651 0.1574
Brugia malayi sulfakinin receptor protein 0.0059 0.0651 0.0651
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0167 0.0167
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0482 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0059 0.0651 0.0651
Loa Loa (eye worm) hypothetical protein 0.0014 0.0115 0.0277
Mycobacterium tuberculosis Long conserved protein 0.0833 1 1
Toxoplasma gondii formyl transferase domain-containing protein 0.0007 0.0019 0.0235
Wolbachia endosymbiont of Brugia malayi phosphoribosylamine--glycine ligase 0.018 0.211 1
Onchocerca volvulus 0.0059 0.0651 0.0651
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.003 0.003
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0005 0 0.0007
Giardia lamblia Transglutaminase/protease, putative 0.0833 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0651 0.0651
Giardia lamblia Hypothetical protein 0.0833 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0651 0.0651

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 47 nM Tested in vitro for cellular cytotoxicity against human T-cell derived lymphoblastic leukemia (CCRF-CEM) cells ChEMBL. No reference
k' (binding) = 20 Ratio of Vmax to Km value of the compound was determined and expressed as k' ChEMBL. No reference
Ki (binding) = 147 nM Tested in vitro for its inhibition of trifunctional glycinamide ribonucleotide formyltransferase (GARFT) isolated from murine L1210 leukemia cells ChEMBL. No reference
Km (binding) = 39 uM Compound was evaluated in vitro for its Folylpoly-gamma-glutamyl synthetase (FPGS) affinity ChEMBL. No reference
Vmax (binding) = 797 nM hr-1 mg-1 Maximum velocity of the compound was evaluated in vitro by using hog liver Folylpoly-gamma-glutamyl synthetase ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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