Detailed information for compound 2073516

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 652.856 | Formula: C36H60O10
  • H donors: 7 H acceptors: 8 LogP: 4.3 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC[C@H]1O[C@@H](O[C@H]2CC[C@]3([C@H](C2(C)C)CC[C@@]2([C@@H]3C[C@@H](O)[C@H]3[C@@]2(C)CC[C@@H]3[C@](CC/C=C(/C(=O)O)\C)(O)C)C)C)[C@@H]([C@H]([C@@H]1O)O)O
  • InChi: 1S/C36H60O10/c1-19(30(42)43)9-8-13-36(7,44)20-10-15-35(6)26(20)21(38)17-24-33(4)14-12-25(32(2,3)23(33)11-16-34(24,35)5)46-31-29(41)28(40)27(39)22(18-37)45-31/h9,20-29,31,37-41,44H,8,10-18H2,1-7H3,(H,42,43)/b19-9+/t20-,21+,22+,23-,24+,25-,26-,27+,28-,29+,31-,33-,34+,35+,36-/m0/s1
  • InChiKey: OWCCERRCKVKBMO-ZYHRFLOWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.0021 0.0056 0.0079
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0056
Leishmania major glycosyl hydrolase-like protein 0.0107 0.0951 0.2672
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0056
Schistosoma mansoni methylthioadenosine phosphorylase 0.0027 0.0116 0.0144
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0426 0.0426
Echinococcus multilocularis uridine phosphorylase 1 0.0027 0.0116 0.0144
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.005 0.0062
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0424 0.1191
Echinococcus multilocularis purine nucleoside phosphorylase 0.013 0.1192 0.1482
Echinococcus granulosus purine nucleoside phosphorylase 0.013 0.1192 0.1482
Entamoeba histolytica hypothetical protein 0.0098 0.0857 0.308
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0011 0.0031
Mycobacterium ulcerans hypothetical protein 0.0021 0.0056 0.0079
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0027 0.0116 0.0144
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0038 0.0047
Leishmania major hypothetical protein, conserved 0.0019 0.0031 0.0087
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0049 0.006
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0248 0.2418 0.3006
Loa Loa (eye worm) fli-1 protein 0.0235 0.2285 0.2284
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0031 0.0092
Schistosoma mansoni uridine phosphorylase 0.0027 0.0116 0.0144
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0021 0.0056 0.0079
Brugia malayi CBS domain containing protein 0.0021 0.0056 0.0056
Plasmodium vivax telomerase reverse transcriptase, putative 0.0022 0.0062 0.0184
Leishmania major inosine-5-monophosphate dehydrogenase 0.0357 0.3558 1
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0248 0.2418 0.3006
Brugia malayi Ets-domain containing protein 0.0077 0.0642 0.0642
Echinococcus multilocularis mannosyl oligosaccharide 1,2 alpha mannosidase 0.0033 0.0176 0.0219
Loa Loa (eye worm) chloride channel protein 7 0.0021 0.0056 0.0056
Leishmania major methylthioadenosine phosphorylase, putative 0.0027 0.0116 0.0326
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0038 0.0047
Loa Loa (eye worm) hypothetical protein 0.0079 0.0664 0.0664
Echinococcus granulosus purine nucleoside phosphorylase 0.013 0.1192 0.1482
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0248 0.2418 0.3006
Entamoeba histolytica hypothetical protein, conserved 0.0059 0.0446 0.1602
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.0587 0.0587
Schistosoma mansoni alpha(13)fucosyltransferase 0.0187 0.1788 0.2223
Echinococcus granulosus alpha13fucosyltransferase 0.0079 0.0664 0.0825
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0357 0.3558 0.4424
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0031 0.0038
Leishmania major guanosine monophosphate reductase 0.0357 0.3558 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.005 0.0062
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.0555 0.1558
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0022 0.0027
Onchocerca volvulus 0.0021 0.005 0.003
Schistosoma mansoni mannosyl-oligosaccharide alpha-12-mannosidase 0.0033 0.0176 0.0219
Echinococcus granulosus geminin 0.0418 0.4193 0.5214
Entamoeba histolytica hypothetical protein 0.0098 0.0857 0.308
Mycobacterium ulcerans cystathionine beta-synthase 0.0021 0.0056 0.0079
Brugia malayi CXXC zinc finger family protein 0.0029 0.0142 0.0142
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0069 0.0552 0.0687
Schistosoma mansoni hypothetical protein 0.0143 0.1327 0.165
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.005 0.005
Schistosoma mansoni mannosidase alpha class 2a 0.0046 0.0316 0.0393
Treponema pallidum uridine phosphorylase (udp) 0.0027 0.0116 0.0417
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.0069 0.0557 0.0692
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0248 0.2418 0.3006
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0555 0.0785
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0169 0.1603 0.4418
Echinococcus multilocularis cpg binding protein 0.0031 0.016 0.0198
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.2781 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0357 0.3558 0.4424
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.005 0.005
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0021 0.0056 0.0079
Echinococcus multilocularis mitochondrial ribosomal protein L17 0.0052 0.0382 0.0475
Schistosoma mansoni coup transcription factor 0.0021 0.005 0.0062
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0021 0.0056 0.0079
Entamoeba histolytica hypothetical protein 0.0098 0.0857 0.308
Trichomonas vaginalis set domain proteins, putative 0.015 0.1396 0.1396
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0357 0.3558 1
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0027 0.0116 0.0116
Echinococcus granulosus glycoprotein 3 alpha L fucosyltransferase 0.0079 0.0664 0.0825
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0031 0.0038
Brugia malayi ancient conserved domain protein 4 0.0021 0.0056 0.0056
Echinococcus multilocularis endo beta n-acetylglucosaminidase 0.0107 0.0951 0.1182
Mycobacterium tuberculosis Conserved protein 0.0021 0.0056 0.0079
Schistosoma mansoni alpha(13)fucosyltransferase 0.0032 0.0164 0.0204
Schistosoma mansoni cpg binding protein 0.0031 0.016 0.0198
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0057 0.0431 0.0536
Brugia malayi Fucosyl transferase family protein 0.0187 0.1788 0.1788
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.013 0.1192 0.1794
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0033 0.0176 0.0176
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.0555 0.0689
Echinococcus granulosus uridine phosphorylase 1 0.0027 0.0116 0.0144
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0021 0.0056 0.007
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0021 0.0056 0.0157
Echinococcus multilocularis microtubule associated protein 2 0.0787 0.8042 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.005 0.0062
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0336 0.3337 0.4725
Brugia malayi steroid hormone receptor 0.0021 0.005 0.005
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0021 0.0056 0.007
Trichomonas vaginalis glucosylceramidase, putative 0.0639 0.6505 0.6505
Plasmodium falciparum phd finger protein, putative 0.0019 0.0031 0.0092
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.0555 0.1558
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0555 0.0785
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.005 0.0062
Giardia lamblia PHD finger protein 15 0.0019 0.0031 0.011
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0103 0.0911 0.1133
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0031
Schistosoma mansoni chloride channel protein 0.0021 0.0056 0.007
Mycobacterium ulcerans purine nucleoside phosphorylase 0.013 0.1192 0.1688
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0336 0.3337 1
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0031 0.0157 0.0196
Schistosoma mansoni alpha(13)fucosyltransferase 0.0187 0.1788 0.2223
Echinococcus multilocularis lysine specific demethylase 5A 0.007 0.057 0.0708
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.005 0.0062
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.005 0.0062
Loa Loa (eye worm) hypothetical protein 0.0018 0.0022 0.0022
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0021 0.0056 0.007
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Brugia malayi Melibiase family protein 0.0165 0.1557 0.1557
Loa Loa (eye worm) chloride channel 3 0.0021 0.0056 0.0056
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0357 0.3558 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0176 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.005 0.005
Schistosoma mansoni jumonji domain containing protein 0.0097 0.0842 0.1047
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.011
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0069 0.0557 0.0812
Brugia malayi Ets-domain containing protein 0.0077 0.0642 0.0642
Trichomonas vaginalis glucosylceramidase, putative 0.0639 0.6505 0.6505
Schistosoma mansoni hypothetical protein 0.0018 0.0022 0.0027
Echinococcus granulosus mannosyl oligosaccharide 12 alpha mannosidase 0.0033 0.0176 0.0219
Echinococcus granulosus purine nucleoside phosphorylase 0.013 0.1192 0.1482
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0019 0.0038 0.0047
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0021 0.0056 0.007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.005 0.005
Trypanosoma cruzi endo-beta-N-acetylglucosaminidase, putative 0.0107 0.0951 0.2672
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2781 0.2781
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0248 0.2418 0.3006
Entamoeba histolytica nucleoside transporter, putative 0.0069 0.0557 0.2001
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0011 0.0033
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0239 0.0239
Brugia malayi jmjC domain containing protein 0.0019 0.0031 0.0031
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0033 0.0176 0.0176
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0069 0.0552 0.1986
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2781 0.2781
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2781 0.2781
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0038 0.0047
Schistosoma mansoni nuclear hormone receptor 0.0021 0.005 0.0062
Echinococcus multilocularis purine nucleoside phosphorylase 0.013 0.1192 0.1482
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0116 0.0116
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0011 0.0016
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.005 0.005
Toxoplasma gondii IMP dehydrogenas 0.0357 0.3558 1
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.005 0.0062
Toxoplasma gondii melibiase subfamily protein 0.0248 0.2418 0.6795
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0587 0.073
Mycobacterium ulcerans thymidine phosphorylase 0.0693 0.7062 1
Brugia malayi alpha1,3-fucosyltransferase homologue 0.0187 0.1788 0.1788
Brugia malayi Pre-SET motif family protein 0.0019 0.0038 0.0038
Entamoeba histolytica hypothetical protein 0.0027 0.0116 0.0417
Onchocerca volvulus 0.0021 0.0056 0.0039
Trypanosoma brucei telomerase reverse transcriptase 0.0022 0.0062 0.0173
Echinococcus granulosus microtubule associated protein 2 0.0787 0.8042 1
Echinococcus granulosus Transcription initiation factor TFIID subunit 0.0048 0.0335 0.0416
Mycobacterium ulcerans glutaminase 0.0391 0.3913 0.554
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0165 0.1557 0.1557
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.005 0.0062
Schistosoma mansoni jumonji/arid domain-containing protein 0.0072 0.0587 0.073
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0357 0.3558 1
Giardia lamblia Telomerase catalytic subunit 0.0022 0.0062 0.0221
Schistosoma mansoni alpha(13)fucosyltransferase 0.0187 0.1788 0.2223
Trypanosoma brucei endo-beta-N-acetylglucosaminidase, putative 0.0107 0.0951 0.2672
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0302 0.2982 0.4559
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0059 0.0446 0.1252
Schistosoma mansoni ets-related 0.0235 0.2285 0.2841
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0114 0.1021 0.1269
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.005 0.0062
Brugia malayi jmjC domain containing protein 0.0072 0.0587 0.0587
Brugia malayi N-terminal motif family protein 0.0302 0.2982 0.2982
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.013 0.1192 0.1688
Leishmania major nucleoside phosphorylase-like protein 0.0027 0.0116 0.0326
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.005 0.003
Trichomonas vaginalis glucosylceramidase, putative 0.0674 0.6864 0.6864
Brugia malayi chloride channel protein 7 0.0021 0.0056 0.0056
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0021 0.0056 0.007
Trichomonas vaginalis glucosylceramidase, putative 0.0974 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0176 0.0176
Brugia malayi Nucleoside transporter family protein 0.0069 0.0557 0.0557
Schistosoma mansoni purine nucleoside phosphorylase 0.013 0.1192 0.1482
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0027 0.0116 0.0326
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.005 0.0062
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0033 0.0176 0.0176
Trichomonas vaginalis glucosylceramidase, putative 0.0639 0.6505 0.6505
Schistosoma mansoni transcription factor LCR-F1 0.0098 0.0857 0.1065
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0148 0.1382 0.1382
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0059 0.0446 0.1252
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0357 0.3558 0.4424
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0018 0.0024 0.0029
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0143 0.1327 0.165
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0069 0.0557 0.0557
Trichomonas vaginalis glucosylceramidase, putative 0.0674 0.6864 0.6864
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0011 0.0031
Brugia malayi loechrig isoform VII 0.0021 0.0056 0.0056
Echinococcus multilocularis GA binding protein alpha chain 0.0077 0.0642 0.0798
Trichomonas vaginalis glucosylceramidase, putative 0.0639 0.6505 0.6505
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.0555 0.0785
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0196 0.1875 0.2655
Plasmodium falciparum telomerase reverse transcriptase 0.0022 0.0062 0.0184
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.005 0.005
Echinococcus multilocularis endoplasmic reticulum mannosyl oligosaccharide 0.0033 0.0176 0.0219
Treponema pallidum Mg2+ transport protein (mgtE) 0.0021 0.0056 0.0201
Trichomonas vaginalis glutaminase, putative 0.0391 0.3913 0.3913
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0059 0.0446 0.0554
Brugia malayi Glycosyl hydrolase family 85 protein 0.0107 0.0951 0.0951
Schistosoma mansoni chloride channel protein 0.0021 0.0056 0.007
Leishmania major telomerase reverse transcriptase, putative 0.0022 0.0062 0.0173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0114 0.1021 0.1269
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0021 0.0056 0.0157
Loa Loa (eye worm) hypothetical protein 0.0302 0.2982 0.2982
Brugia malayi hypothetical protein 0.0098 0.0857 0.0857
Echinococcus multilocularis transfer RNA-Trp 0.0033 0.0176 0.0219
Echinococcus granulosus H:Cl exchange transporter 3 0.0021 0.0056 0.007
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0031 0.0038
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0033 0.0176 0.0176
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0011 0.0014
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0196 0.1875 0.2655
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0114 0.1021 0.102
Echinococcus granulosus purine nucleoside phosphorylase 0.013 0.1192 0.1482
Schistosoma mansoni gabp alpha 0.0077 0.0642 0.0798
Schistosoma mansoni methylthioadenosine phosphorylase 0.0027 0.0116 0.0144
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.1274 0.1804
Echinococcus granulosus dnaJ subfamily B 0.0419 0.4208 0.5233
Echinococcus granulosus GA binding protein alpha chain 0.0077 0.0642 0.0798
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0069 0.0557 0.0692
Schistosoma mansoni hypothetical protein 0.0018 0.0022 0.0027
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0027 0.0116 0.0417
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0116 0.0116
Schistosoma mansoni glutaminase 0.0391 0.3913 0.4865
Giardia lamblia Fructose-bisphosphate aldolase 0.0282 0.2781 1
Schistosoma mansoni hypothetical protein 0.0418 0.4193 0.5214
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0022 0.0062 0.0173
Loa Loa (eye worm) fucosyl transferase 0.0187 0.1788 0.1787
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0027 0.0116 0.0417
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.005 0.005
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0336 0.3337 1
Trichomonas vaginalis beta-glucosidase, putative 0.004 0.0257 0.0257
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0357 0.3558 1
Echinococcus multilocularis alpha(13)fucosyltransferase 0.0079 0.0664 0.0825
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0069 0.0552 0.0552
Onchocerca volvulus Putative GMP reductase 0.0148 0.1382 0.2087
Loa Loa (eye worm) PHD-finger family protein 0.0019 0.0031 0.0031
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0031 0.0038
Loa Loa (eye worm) loechrig isoform VII 0.0021 0.0056 0.0056
Echinococcus granulosus peregrin 0.0019 0.0031 0.0038
Wolbachia endosymbiont of Brugia malayi Mg/Co/Ni transporter MgtE 0.0021 0.0056 0.0157
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0027 0.0116 0.0164
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0021 0.0056 0.0157
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0027 0.0116 0.0417
Loa Loa (eye worm) glycosyl hydrolase family 38 protein 0.0031 0.0157 0.0157
Leishmania major eukaryotic translation initiation factor-like 0.0069 0.0552 0.1553
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0031 0.0087
Schistosoma mansoni alpha(13)fucosyltransferase 0.0032 0.0164 0.0204
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.005 0.0062
Schistosoma mansoni cpg binding protein 0.0029 0.0142 0.0177
Trichomonas vaginalis glucosylceramidase, putative 0.0974 1 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0019 0.0031 0.0038
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0169 0.1603 0.227
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0027 0.0116 0.0417
Toxoplasma gondii CBS family protein 0.0021 0.0056 0.0157
Leishmania major eukaryotic translation initiation factor-like protein 0.0069 0.0552 0.1553
Schistosoma mansoni chloride channel protein 0.0021 0.0056 0.007
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0033 0.0176 0.0176
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0027 0.0116 0.0417
Brugia malayi jmjC domain containing protein 0.0019 0.0031 0.0031
Onchocerca volvulus Alpha 1,3 fucosyltransferase homolog 0.0079 0.0664 0.0978
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.005 0.0062
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.005 0.0062
Schistosoma mansoni hypothetical protein 0.0018 0.0022 0.0027
Schistosoma mansoni purine nucleoside phosphorylase 0.013 0.1192 0.1482
Trypanosoma cruzi GMP reductase 0.0357 0.3558 1
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0033 0.0176 0.0176
Schistosoma mansoni thyroid hormone receptor 0.0164 0.1542 0.1917
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0027 0.0116 0.0116
Toxoplasma gondii Alpha-galactosidase 0.0035 0.0201 0.0564
Echinococcus multilocularis glycoprotein 3 alpha L fucosyltransferase 0.0079 0.0664 0.0825
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2781 0.2781
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0011 0.0014
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0027 0.0116 0.0417
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0027 0.0116 0.0348
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0079 0.0665 0.0979
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0021 0.0056 0.007
Loa Loa (eye worm) hypothetical protein 0.0057 0.0426 0.0426
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.005 0.005
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0035 0.0201 0.0249
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0098 0.0857 0.1065
Toxoplasma gondii phosphorylase family protein 0.0027 0.0116 0.0326
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0021 0.0056 0.007
Echinococcus granulosus FTZ F1 alpha 0.0021 0.005 0.0062
Toxoplasma gondii RNA-directed DNA polymerase 0.0022 0.0062 0.0173
Echinococcus multilocularis jumonji domain containing protein 0.0026 0.0107 0.0133
Loa Loa (eye worm) GMP reductase 0.0148 0.1382 0.1382
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0248 0.2418 0.3006
Echinococcus multilocularis thymidine phosphorylase 0.0693 0.7062 0.8782
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0031 0.0157 0.0196
Brugia malayi GMP reductase 0.0148 0.1382 0.1382
Schistosoma mansoni hypothetical protein 0.0053 0.0388 0.0482
Wolbachia endosymbiont of Brugia malayi hemolysin 0.0021 0.0056 0.0157
Echinococcus multilocularis glycoprotein 3 alpha L fucosyltransferase 0.0079 0.0664 0.0825
Schistosoma mansoni hypothetical protein 0.0018 0.0022 0.0027
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.013 0.1192 0.1192
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0011 0.0014
Plasmodium vivax SET domain protein, putative 0.0019 0.0038 0.0113
Chlamydia trachomatis AMP nucleosidase 0.0027 0.0116 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0077 0.0642 0.0642
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0027 0.0116 0.0326
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.005 0.005
Brugia malayi Fli-1 protein 0.0235 0.2285 0.2285
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0357 0.3558 0.5038
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0021 0.0056 0.0201
Schistosoma mansoni hypothetical protein 0.0419 0.4208 0.5233
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0027 0.0116 0.0116
Mycobacterium leprae probable uridine phosphorylase 0.0027 0.0116 0.0171
Leishmania major hypothetical protein, conserved 0.0021 0.0056 0.0157
Loa Loa (eye worm) hypothetical protein 0.0066 0.0525 0.0525
Echinococcus multilocularis lysosomal alpha mannosidase 0.0031 0.0157 0.0196
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0114 0.1021 0.1021
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0011 0.0031
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0239 0.0239
Brugia malayi uridine phosphorylase family protein 0.0027 0.0116 0.0116
Mycobacterium tuberculosis Conserved hypothetical protein 0.0027 0.0116 0.0164
Onchocerca volvulus 0.0029 0.0142 0.0172
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0069 0.0552 0.1553
Echinococcus multilocularis purine nucleoside phosphorylase 0.013 0.1192 0.1482
Leishmania major glycosyl transferase, putative 0.0032 0.0164 0.0461
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.013 0.1192 0.4287
Brugia malayi hypothetical protein 0.0069 0.0557 0.0557
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0027 0.0116 0.0326
Schistosoma mansoni protein kinase subunit gamma 0.0021 0.0056 0.007
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0022 0.0022
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0011 0.0033
Echinococcus granulosus jumonji domain containing protein 0.0026 0.0107 0.0133
Loa Loa (eye worm) glycosyl hydrolase family 85 protein 0.0107 0.0951 0.0951
Brugia malayi CLC chloride channel protein 0.0021 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0038
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0069 0.0552 0.1986
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0031 0.0086
Loa Loa (eye worm) hypothetical protein 0.0046 0.0316 0.0316
Schistosoma mansoni alpha(13)fucosyltransferase 0.0032 0.0164 0.0204
Trichomonas vaginalis glucosylceramidase, putative 0.0974 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.005 0.003
Trichomonas vaginalis glucosylceramidase, putative 0.0974 1 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0031 0.0093
Echinococcus granulosus equilibrative nucleoside transporter 3 0.0069 0.0557 0.0692
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0069 0.0557 0.0557
Brugia malayi lysosomal alpha-mannosidase 0.0031 0.0157 0.0157
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0021 0.0056 0.0079
Schistosoma mansoni hypothetical protein 0.0418 0.4193 0.5214
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0021 0.0056 0.0079
Brugia malayi Pre-SET motif family protein 0.0132 0.1207 0.1207
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0011 0.0014
Echinococcus granulosus PHD finger protein rhinoceros 0.0019 0.0031 0.0038
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0011 0.0014
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0022 0.0027
Trichomonas vaginalis glucosylceramidase, putative 0.0639 0.6505 0.6505
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0021 0.0056 0.0201
Echinococcus granulosus purine nucleoside phosphorylase 0.013 0.1192 0.1482
Trypanosoma cruzi GMP reductase 0.0357 0.3558 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.2781 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0187 0.179 0.4951
Brugia malayi PHD-finger family protein 0.0019 0.0031 0.0031
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0011 0.0031
Loa Loa (eye worm) hypothetical protein 0.0165 0.1557 0.1557
Treponema pallidum fructose-bisphosphate aldolase 0.0282 0.2781 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0494 0.0614
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0357 0.3558 1
Echinococcus multilocularis glycoprotein 3 alpha L fucosyltransferase 0.0079 0.0664 0.0825
Mycobacterium ulcerans hypothetical protein 0.0021 0.0056 0.0079
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2781 0.2781
Schistosoma mansoni hypothetical protein 0.0039 0.0239 0.0297
Mycobacterium ulcerans alpha-mannosidase 0.0031 0.0157 0.0223
Schistosoma mansoni hypothetical protein 0.0059 0.0446 0.0554
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0059 0.0446 0.1252
Brugia malayi nuclear receptor NHR-88 0.0021 0.005 0.005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0555 0.0785
Onchocerca volvulus 0.0031 0.0157 0.0196
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.005 0.005
Toxoplasma gondii CBS domain-containing protein 0.0021 0.0056 0.0157
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.1274 0.1804
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0027 0.0116 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.005 0.005
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0031 0.0038
Plasmodium falciparum protein MAM3, putative 0.0021 0.0056 0.0168
Leishmania major chloride channel protein, putative 0.0021 0.0056 0.0157
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0165 0.1557 0.1936
Brugia malayi glutaminase DH11.1 0.0391 0.3913 0.3913
Echinococcus granulosus thymidine phosphorylase 0.0693 0.7062 0.8782
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.005 0.005
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.013 0.1192 0.3244
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.1274 0.3479
Brugia malayi isocitrate dehydrogenase 0.0017 0.0011 0.0011
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0027 0.0116 0.0326
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0069 0.0552 0.1553
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0027 0.0116 0.0164
Giardia lamblia Rrm3p helicase 0.0059 0.0446 0.1602
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.005 0.005
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0059 0.0446 0.1252
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0069 0.0557 0.0812
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0069 0.0552 0.0687
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0011 0.0011
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0109 0.0974 0.1211
Schistosoma mansoni alpha(13)fucosyltransferase 0.0187 0.1788 0.2223
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0033 0.0176 0.0176
Schistosoma mansoni alpha(13)fucosyltransferase 0.0032 0.0164 0.0204
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0114 0.1021 0.1269
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0031 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.005 0.005
Mycobacterium tuberculosis Hypothetical protein 0.0027 0.0116 0.0164
Schistosoma mansoni microtubule-associated protein tau 0.0787 0.8042 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0031 0.0086
Brugia malayi Bromodomain containing protein 0.0019 0.0031 0.0031
Trypanosoma cruzi endo-beta-N-acetylglucosaminidase, putative 0.0107 0.0951 0.2672
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0164 0.0461
Echinococcus granulosus glycoprotein 3 alpha L fucosyltransferase 0.0079 0.0664 0.0825
Loa Loa (eye worm) translation initiation factor 4E 0.0069 0.0552 0.0552
Schistosoma mansoni hypothetical protein 0.0098 0.0857 0.1065
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0069 0.0557 0.0557
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0019 0.0031 0.0038
Trichomonas vaginalis alpha-mannosidase, putative 0.0031 0.0157 0.0157
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0022 0.0027
Schistosoma mansoni methylthioadenosine phosphorylase 0.0027 0.0116 0.0144
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2781 0.2781
Echinococcus multilocularis purine nucleoside phosphorylase 0.013 0.1192 0.1482
Schistosoma mansoni alpha(13)fucosyltransferase 0.0032 0.0164 0.0204
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0038 0.0047
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0148 0.1382 0.1382
Trichomonas vaginalis glycoside hydrolases, putative 0.004 0.0257 0.0257
Onchocerca volvulus 0.0019 0.0038 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0974 1 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0069 0.0552 0.0552
Echinococcus multilocularis purine nucleoside phosphorylase 0.013 0.1192 0.1482
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.005 0.0062
Toxoplasma gondii CBS domain-containing protein 0.0021 0.0056 0.0157
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0164 0.0461
Brugia malayi jmjC domain containing protein 0.0019 0.0031 0.0031
Brugia malayi nuclear hormone receptor 0.0021 0.005 0.005
Treponema pallidum pfs protein (pfs) 0.0027 0.0116 0.0417
Echinococcus multilocularis geminin 0.0418 0.4193 0.5214
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.013 0.1192 0.1192
Brugia malayi jmjC domain containing protein 0.0019 0.0031 0.0031
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0031 0.0038
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0033 0.0176 0.0176
Echinococcus multilocularis peregrin 0.0019 0.0031 0.0038
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0248 0.2418 0.3006
Plasmodium falciparum purine nucleoside phosphorylase 0.0027 0.0116 0.0348
Trichomonas vaginalis glucosylceramidase, putative 0.0974 1 1
Trypanosoma cruzi lysosomal alpha-mannosidase precursor, putative 0.0031 0.0157 0.0442
Echinococcus multilocularis Transcription initiation factor TFIID subunit 0.0048 0.0335 0.0416
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0038 0.0047
Plasmodium vivax JmjC domain containing protein 0.0019 0.0031 0.0093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2781 0.2781
Echinococcus granulosus H:Cl exchange transporter 4 0.0021 0.0056 0.007
Brugia malayi translation initiation factor 4E 0.0069 0.0552 0.0552
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0069 0.0552 0.0552
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0027 0.0116 0.0116
Trypanosoma brucei GMP reductase 0.0357 0.3558 1
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0027 0.0116 0.0164
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0069 0.0557 0.0557
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0027 0.0116 0.0116
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0027 0.0116 0.0326
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.1542 0.1917
Loa Loa (eye worm) hypothetical protein 0.0103 0.0911 0.0911
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0069 0.0557 0.0557
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.005 0.0062
Echinococcus multilocularis alpha mannosidase 2 0.0046 0.0316 0.0393
Echinococcus granulosus lysine specific demethylase 5A 0.0072 0.0587 0.073
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0022 0.0062 0.0173
Schistosoma mansoni uridine phosphorylase 0.0027 0.0116 0.0144
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0426 0.0426
Schistosoma mansoni thyroid hormone receptor 0.0164 0.1542 0.1917
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0069 0.0552 0.1553
Echinococcus multilocularis purine nucleoside phosphorylase 0.0103 0.0911 0.1133
Echinococcus granulosus mitochondrial ribosomal protein L17 0.0052 0.0382 0.0475
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0056
Onchocerca volvulus Glucosylceramidase homolog 0.0639 0.6505 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.005 0.005
Echinococcus granulosus endo beta n-acetylglucosaminidase 0.0107 0.0951 0.1182
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0446 0.0445
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.005 0.0062
Loa Loa (eye worm) glutaminase 0.0391 0.3913 0.3913
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0056
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0021 0.0056 0.0157
Giardia lamblia Hypothetical protein 0.0069 0.0557 0.2001
Echinococcus granulosus lysosomal alpha mannosidase 0.0031 0.0157 0.0196
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0069 0.0552 0.1553
Loa Loa (eye worm) hypothetical protein 0.0048 0.0335 0.0335
Onchocerca volvulus 0.015 0.1396 0.2109
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0011 0.0031
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0021 0.0056 0.0079
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0114 0.1021 0.1269
Leishmania major chloride channel protein, putative 0.0021 0.0056 0.0157
Echinococcus granulosus methylthioadenosine phosphorylase 0.0027 0.0116 0.0144
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0974 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.005 0.005
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0022 0.0027
Loa Loa (eye worm) uridine phosphorylase 0.0027 0.0116 0.0116
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0165 0.1557 0.1936
Loa Loa (eye worm) hypothetical protein 0.0039 0.0239 0.0239
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.005 0.005
Loa Loa (eye worm) IMP dehydrogenase 1 0.0357 0.3558 0.3558
Schistosoma mansoni alpha(13)fucosyltransferase 0.0187 0.1788 0.2223
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.4208 0.5233
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Trypanosoma brucei lysosomal alpha-mannosidase precursor, putative 0.0031 0.0157 0.0442
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0031 0.0087
Leishmania major CBS domain protein, conserved 0.0021 0.0056 0.0157
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0031 0.0038
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0426 0.0426
Echinococcus multilocularis glycoprotein 3 alpha L fucosyltransferase 0.0079 0.0664 0.0825
Echinococcus granulosus purine nucleoside phosphorylase 0.013 0.1192 0.1482
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0031 0.0038
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.0555 0.0689
Trypanosoma cruzi chloride channel protein, putative 0.0021 0.0056 0.0157
Mycobacterium tuberculosis Conserved protein 0.0021 0.0056 0.0079
Loa Loa (eye worm) hypothetical protein 0.0045 0.0303 0.0303
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0011 0.0014
Loa Loa (eye worm) MH2 domain-containing protein 0.0155 0.145 0.145
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0021 0.0056 0.0157
Schistosoma mansoni alpha 13/4 fucosyltransferase Lewis 1 0.0108 0.0959 0.1192
Trypanosoma cruzi lysosomal alpha-mannosidase precursor, putative 0.0031 0.0157 0.0442
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0031 0.0087
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0019 0.0038 0.0106
Trypanosoma cruzi chloride channel protein, putative 0.0021 0.0056 0.0157
Entamoeba histolytica hypothetical protein 0.0098 0.0857 0.308
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0357 0.3558 0.3558
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.005 0.0062
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.005 0.0062
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Brugia malayi Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform 1 0.0033 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0187 0.1788 0.1787
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0059 0.0446 0.1252
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0022 0.0022
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0143 0.1327 0.165
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0114 0.1021 0.1269
Giardia lamblia UPL-1 0.0027 0.0116 0.0417
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0187 0.179 0.2534
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0021 0.0056 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.005 0.005
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0031 0.0031
Brugia malayi Glycosyl hydrolases family 38 protein 0.0031 0.0157 0.0157
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0033 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0021 0.005 0.005
Echinococcus granulosus alpha mannosidase 2 0.0026 0.011 0.0136
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0021 0.0056 0.0157
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0021 0.0056 0.007
Mycobacterium ulcerans transcriptional regulator 0.0021 0.0056 0.0079
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.005 0.0062
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0031 0.0087
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0033 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0028 0.0129 0.0129
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.002 0.0041 0.0051
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0027 0.0116 0.0417
Brugia malayi ancient conserved domain protein 2 0.0021 0.0056 0.0056
Brugia malayi hypothetical protein 0.0052 0.0382 0.0382
Onchocerca volvulus 0.0031 0.0157 0.0196
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0021 0.0056 0.0201
Echinococcus granulosus equilibrative nucleoside transporter 0.0069 0.0557 0.0692
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0041
Schistosoma mansoni alpha(13)fucosyltransferase 0.0032 0.0164 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.005 0.005
Trypanosoma cruzi chloride channel protein, putative 0.0021 0.0056 0.0157
Entamoeba histolytica DNA repair and recombination protein, putative 0.0059 0.0446 0.1602
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.005 0.0062
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0033 0.0176 0.0176
Echinococcus granulosus cpg binding protein 0.0031 0.016 0.0198
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0011 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0069 0.0557 0.0557
Echinococcus multilocularis purine nucleoside phosphorylase 0.0103 0.0911 0.1133
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.005 0.005
Trichomonas vaginalis glucosylceramidase, putative 0.0639 0.6505 0.6505
Loa Loa (eye worm) hypothetical protein 0.0033 0.0176 0.0176
Echinococcus multilocularis GPCR, family 2 0.0018 0.0022 0.0027
Echinococcus granulosus phd:f box containing protein 0.0019 0.0031 0.0038
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0041
Echinococcus multilocularis glycoprotein 3 alpha L fucosyltransferase 0.0079 0.0664 0.0825
Echinococcus granulosus glycoprotein 3 alpha L fucosyltransferase 0.0079 0.0664 0.0825
Brugia malayi jmjC domain containing protein 0.0109 0.0974 0.0974
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0031 0.0038
Brugia malayi Voltage gated chloride channel family protein 0.0021 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0031 0.0157 0.0157
Toxoplasma gondii phosphorylase family protein 0.0027 0.0116 0.0326
Schistosoma mansoni hypothetical protein 0.0019 0.0031 0.0038
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.005 0.0062
Echinococcus granulosus H:Cl exchange transporter 7 0.0021 0.0056 0.007
Brugia malayi Glycosyl hydrolases family 38 protein 0.0031 0.0157 0.0157
Schistosoma mansoni alpha(13)fucosyltransferase 0.0032 0.0164 0.0204
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0114 0.1021 0.1269
Echinococcus granulosus alpha mannosidase 2 0.0024 0.009 0.0112
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0021 0.0056 0.0157
Loa Loa (eye worm) glutaminase 2 0.0391 0.3913 0.3913
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0019 0.0038 0.0047
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0031 0.0087
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.005 0.0062
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.005 0.003
Echinococcus granulosus endoplasmic reticulum mannosyl oligosaccharide 0.0033 0.0176 0.0219
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0059 0.0446 0.1252
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0555 0.0689
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0011 0.0011
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0021 0.0056 0.007
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0027 0.0116 0.0116
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0069 0.0552 0.0687
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0011 0.0031
Echinococcus granulosus glycoprotein 3 alpha L fucosyltransferase 0.0079 0.0664 0.0825
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0027 0.0116 0.0417
Treponema pallidum hemolysin (tlyC) 0.0021 0.0056 0.0201
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0031 0.0038
Loa Loa (eye worm) transcription factor SMAD2 0.0155 0.145 0.145
Wolbachia endosymbiont of Brugia malayi Mg2+/Co2+ transporter 0.0021 0.0056 0.0157
Trypanosoma brucei uridine phosphorylase 0.0027 0.0116 0.0326
Brugia malayi Glycosyl hydrolases family 38 protein 0.0046 0.0316 0.0316
Echinococcus granulosus GPCR family 2 0.0018 0.0022 0.0027
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0357 0.3558 1
Brugia malayi Telomerase reverse transcriptase 0.0058 0.0438 0.0438
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0069 0.0552 0.1553
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0033 0.0176 0.0176
Brugia malayi ecdysteroid receptor 0.0021 0.005 0.005
Mycobacterium ulcerans hypothetical protein 0.0021 0.0056 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.005 0.005
Echinococcus granulosus purine nucleoside phosphorylase 0.013 0.1192 0.1482
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0069 0.0552 0.0552
Echinococcus multilocularis purine nucleoside phosphorylase 0.013 0.1192 0.1482
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.005 0.005
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0109 0.0974 0.1211
Loa Loa (eye worm) mannosidase 0.0033 0.0176 0.0176
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0114 0.1021 0.1269
Schistosoma mansoni endo beta n-acetylglucosaminidase 0.0107 0.0951 0.1182
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0059 0.0446 0.0554
Echinococcus multilocularis alpha(13)fucosyltransferase 0.0079 0.0664 0.0825
Trypanosoma brucei lysosomal alpha-mannosidase precursor, putative 0.0022 0.0061 0.017
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0098 0.0857 0.1065
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.005 0.0062
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0027 0.0116 0.0116
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0027 0.0116 0.0417
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.005 0.0062
Brugia malayi MTAP 0.0027 0.0116 0.0116
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.005 0.0062
Echinococcus granulosus purine nucleoside phosphorylase 0.013 0.1192 0.1482
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0027 0.0116 0.0326
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2781 0.2781
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0021 0.0056 0.007
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0011 0.0014
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0142 0.0142
Schistosoma mansoni alpha(13)fucosyltransferase 0.0032 0.0164 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.005 0.005
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0049 0.006
Schistosoma mansoni cpg binding protein 0.0031 0.016 0.0198
Toxoplasma gondii Purine nucleoside phosphorylase 0.0027 0.0116 0.0326
Brugia malayi MH2 domain containing protein 0.0155 0.145 0.145
Giardia lamblia Hypothetical protein 0.0021 0.0056 0.0201
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0357 0.3558 0.5038
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0031 0.0038
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0132 0.1207 0.1207
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0059 0.0446 0.1252
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0555 0.0689
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0196 0.1875 0.5194
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.0693 0.7062 1
Trypanosoma cruzi chloride channel protein, putative 0.0021 0.0056 0.0157
Loa Loa (eye worm) hypothetical protein 0.0069 0.0557 0.0557
Trichomonas vaginalis glucosylceramidase, putative 0.0639 0.6505 0.6505
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0033 0.0176 0.0176
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0031 0.0157 0.0157

Activities

Activity type Activity value Assay description Source Reference
Drug metabolism (ADMET) Drug level in human recombinant CYP3A4 treated with 10 uM 20(S)-ginsenoside Rh2 for 60 mins by MS2 spectra ChEMBL. 22829543
Drug metabolism (ADMET) Drug level in human recombinant CYP3A5 treated with 10 uM 20(S)-ginsenoside Rh2 for 60 mins by MS2 spectra ChEMBL. 22829543
Retention_time (ADMET) = 14 min Retention time in human liver microsomes treated with 10 uM 20(S)-ginsenoside Rh2 by MS2 spectra ChEMBL. 22829543

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.