Detailed information for compound 236486

Basic information

Technical information
  • TDR Targets ID: 236486
  • Name: N-(6-phenyl-4-piperidin-1-yl-5H-pyrrolo[3,2-d ]pyrimidin-2-yl)benzamide
  • MW: 397.472 | Formula: C24H23N5O
  • H donors: 2 H acceptors: 3 LogP: 4.55 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)Nc1nc2cc([nH]c2c(n1)N1CCCCC1)c1ccccc1
  • InChi: 1S/C24H23N5O/c30-23(18-12-6-2-7-13-18)28-24-26-20-16-19(17-10-4-1-5-11-17)25-21(20)22(27-24)29-14-8-3-9-15-29/h1-2,4-7,10-13,16,25H,3,8-9,14-15H2,(H,26,27,28,30)
  • InChiKey: FUBYMNOHRDBHBO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[6-phenyl-4-(1-piperidyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl]benzamide
  • N-(6-phenyl-4-piperidino-5H-pyrrolo[3,2-d]pyrimidin-2-yl)benzamide
  • N-(6-phenyl-4-piperidin-1-yl-5H-pyrrolo[2,3-e]pyrimidin-2-yl)benzamide
  • N-[6-phenyl-4-(1-piperidyl)-5H-pyrrolo[2,3-e]pyrimidin-2-yl]benzamide
  • N-(6-phenyl-4-piperidino-5H-pyrrolo[2,3-e]pyrimidin-2-yl)benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide Y receptor Y5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) acyl carrier protein 0.0075 0.074 0.0776
Toxoplasma gondii ABC1 family protein 0.0111 0.1151 0.1146
Schistosoma mansoni hypothetical protein 0.0361 0.4019 0.4208
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0333 0.263
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0118 0.1234 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0118 0.1234 0.1284
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0068 0.0003
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0085 0.0075
Onchocerca volvulus 0.0111 0.1151 0.1196
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.1151 0.1198
Leishmania major hypothetical protein, conserved 0.0026 0.0171 0.1179
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0487 0.3802
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0841 0.9538 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0102 0.058
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0333 0.252
Echinococcus multilocularis BC026374 protein (S09 family) 0.0012 0.0011 0.0002
Mycobacterium leprae Probable oxidireductase 0.0118 0.1234 0.1267
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0708 0.801 0.8396
Onchocerca volvulus Putative alcohol dehydrogenase 0.0841 0.9538 1
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0118 0.1234 0.1284
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0333 0.2036
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.1151 0.1196
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0118 0.1234 0.1284
Schistosoma mansoni hypothetical protein 0.0049 0.0442 0.0454
Schistosoma mansoni metabotropic glutamate receptor 0.0035 0.0277 0.0281
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0487 0.3802
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0102 0.058
Loa Loa (eye worm) hypothetical protein 0.0118 0.1234 0.1294
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0102 0.058
Mycobacterium ulcerans oxidoreductase 0.0075 0.074 0.0766
Brugia malayi Carboxylesterase family protein 0.0012 0.0011 0.0012
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0487 0.0445
Brugia malayi mbt repeat family protein 0.0099 0.1015 0.1064
Echinococcus multilocularis polycomb protein SCMH1 0.0099 0.1015 0.1007
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0118 0.1234 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0069 0.0666 0.0699
Onchocerca volvulus Fatty acid synthase homolog 0.0075 0.074 0.0766
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0118 0.1234 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0011 0.0002
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0487 0.3802
Loa Loa (eye worm) hypothetical protein 0.0026 0.0171 0.0179
Echinococcus granulosus metabotropic glutamate receptor 5 0.0051 0.0464 0.1025
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0487 0.3892
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0102 0.0609
Echinococcus multilocularis cpg binding protein 0.0031 0.0233 0.0224
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0065 0.0059
Schistosoma mansoni DNA polymerase eta 0.002 0.0102 0.0098
Schistosoma mansoni survival motor neuron protein 0.0049 0.0442 0.0454
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0591 0.061
Leishmania major DNA polymerase kappa, putative 0.002 0.0102 0.0609
Brugia malayi Carboxylesterase family protein 0.0012 0.0011 0.0012
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0118 0.1234 0.1284
Loa Loa (eye worm) hypothetical protein 0.0241 0.2645 0.2773
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0333 0.5
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.1151 0.1196
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0442 0.0464
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0487 0.1076
Brugia malayi hypothetical protein 0.0026 0.0171 0.0179
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0043 0.0371 0.0378
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0308 0.0299
Echinococcus granulosus geminin 0.0361 0.4019 0.9028
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.1151 0.1196
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0068 0.0071
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0171 0.0974
Brugia malayi hypothetical protein 0.0012 0.0011 0.0012
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0487 0.0511
Brugia malayi jmjC domain containing protein 0.0016 0.0065 0.0069
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0102 0.0209
Trypanosoma cruzi oxidoreductase, putative 0.0118 0.1234 1
Brugia malayi jmjC domain containing protein 0.0016 0.0065 0.0069
Brugia malayi Carboxylesterase family protein 0.0012 0.0011 0.0012
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0113 0.1172 0.2619
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0029 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0012
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0322 0.243
Brugia malayi jmjC domain containing protein 0.0061 0.0581 0.0609
Brugia malayi jmjC domain containing protein 0.0016 0.0065 0.0069
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0581 0.1287
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0398 0.4451 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0157 0.1678 0.1759
Schistosoma mansoni inositol monophosphatase 0.0039 0.0322 0.0328
Schistosoma mansoni cpg binding protein 0.0029 0.0214 0.0215
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0371 0.2841
Brugia malayi hypothetical protein 0.0241 0.2645 0.2773
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0118 0.1234 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0068 0.0292
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0068 0.0022
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0118 0.1234 0.1284
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.06 0.062
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0841 0.9538 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0068 0.0058
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1151 0.932
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0102 0.0107
Loa Loa (eye worm) carboxylesterase 0.0069 0.0666 0.0699
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0487 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0099 0.1015 0.1054
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0102 0.0609
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0069
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.1151 0.1142
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0013 0.0029 0.0147
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0113 0.1172 0.1229
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0029 0.0147
Schistosoma mansoni myelin transcription factor 1 myt1 0.0113 0.1172 0.122
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0333 0.0349
Leishmania major quinone oxidoreductase, putative 0.0118 0.1234 1
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1151 0.932
Schistosoma mansoni acetylcholinesterase 0.0012 0.0011 0.0002
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0487 0.3802
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.1151 0.9307
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0214 0.0224
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0102 0.0096
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0069
Loa Loa (eye worm) hypothetical protein 0.0069 0.0666 0.0699
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0333 0.0338
Brugia malayi MAP kinase sur-1 0.0053 0.0487 0.0511
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0068 0.0058
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0118 0.1234 0.1284
Echinococcus granulosus single minded 2 0.0037 0.0308 0.0673
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0029 0.0147
Loa Loa (eye worm) inositol-1 0.0039 0.0322 0.0337
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0102 0.0093
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0065 0.0056
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0102 0.0609
Schistosoma mansoni cpg binding protein 0.0031 0.0233 0.0235
Brugia malayi Carboxylesterase family protein 0.0012 0.0011 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0433 0.0445
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0012
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0171 0.1152
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0029 0.0147
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0171 0.3954
Mycobacterium ulcerans dehydrogenase 0.0118 0.1234 0.1284
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0322 0.243
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0035 0.0046
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0011 0.0002
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0333 0.263
Brugia malayi metabotropic glutamate receptor type 2 0.002 0.011 0.0115
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0487 0.0478
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0404 0.0424
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0841 0.9538 1
Echinococcus granulosus neuroligin 0.0012 0.0011 0.0004
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.1151 0.1207
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0581 0.0572
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0102 0.058
Mycobacterium ulcerans oxidoreductase 0.0118 0.1234 0.1284
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0065 0.0069
Echinococcus multilocularis SAM and MBT domain containing protein 0.0099 0.1015 0.1007
Mycobacterium tuberculosis Possible dehydrogenase 0.0118 0.1234 0.1284
Brugia malayi PAS domain containing protein 0.0051 0.0459 0.0482
Echinococcus multilocularis geminin 0.0361 0.4019 0.4013
Leishmania major d-xylulose reductase, putative 0.0118 0.1234 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0275 0.0259
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0118 0.1234 0.1284
Mycobacterium leprae Probable polyketide synthase Pks1 0.0118 0.1234 0.1267
Mycobacterium tuberculosis Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0723 0.8182 0.8577
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0012
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0102 0.058
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0841 0.9538 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0065 0.0302
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0102 0.058
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0118 0.1234 0.1284
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0068 0.0071
Mycobacterium tuberculosis Possible dehydrogenase 0.0118 0.1234 0.1284
Leishmania major zinc binding dehydrogenase-like protein 0.0118 0.1234 1
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0118 0.1234 0.1226
Schistosoma mansoni metabotropic glutamate receptor 0.002 0.011 0.0106
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0308 0.0312
Echinococcus granulosus synaptic vesicle membrane protein VAT 1 0.0043 0.0371 0.0815
Loa Loa (eye worm) MBCTL1 0.0113 0.1172 0.1229
Echinococcus granulosus SAM and MBT domain containing protein 0.0099 0.1015 0.2264
Mycobacterium ulcerans beta-lactamase 0.0111 0.1151 0.1196
Schistosoma mansoni ap endonuclease 0.004 0.0333 0.0339
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0118 0.1234 0.1284
Echinococcus multilocularis para nitrobenzyl esterase 0.0012 0.0011 0.0002
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0068 0.0089
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0275 0.0277
Plasmodium vivax hypothetical protein, conserved 0.0111 0.1151 1
Echinococcus granulosus acetylcholinesterase 0.0069 0.0666 0.1479
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 0.0723 0.8182 0.8577
Onchocerca volvulus 0.0111 0.1151 0.1196
Schistosoma mansoni sex comb on midleg homolog 0.0099 0.1015 0.1055
Echinococcus granulosus histone acetyltransferase MYST2 0.0113 0.1172 0.2619
Mycobacterium ulcerans alcohol dehydrogenase AdhA 0.0043 0.0371 0.0378
Mycobacterium ulcerans oxidoreductase 0.0043 0.0371 0.0378
Schistosoma mansoni BC026374 protein (S09 family) 0.0012 0.0011 0.0002
Leishmania major protein kinase, putative 0.0014 0.0035 0.0046
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0841 0.9538 1
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0065 0.0059
Trypanosoma cruzi oxidoreductase, putative 0.0118 0.1234 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0102 0.058
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0035 0.0277 0.0268
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0065 0.0069
Loa Loa (eye worm) hypothetical protein 0.0111 0.1151 0.1207
Brugia malayi Carboxylesterase family protein 0.0069 0.0666 0.0699
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0118 0.1234 0.1267
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1151 0.932
Toxoplasma gondii quinone oxidoreductase, putative 0.0118 0.1234 0.1234
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0102 0.058
Mycobacterium ulcerans quinone oxidoreductase 0.0118 0.1234 0.1284
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0581 0.0572
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0171 0.1179
Mycobacterium tuberculosis Conserved protein 0.0111 0.1151 0.1196
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0118 0.1234 1
Loa Loa (eye worm) glutamate receptor 0.0016 0.0065 0.0068
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0841 0.9538 1
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.06 0.133
Loa Loa (eye worm) hypothetical protein 0.0051 0.0464 0.0487
Schistosoma mansoni quinone oxidoreductase 0.0043 0.0371 0.038
Brugia malayi Carboxylesterase family protein 0.0069 0.0666 0.0699
Brugia malayi beta-lactamase 0.0111 0.1151 0.1207
Brugia malayi hypoxia-induced factor 1 0.0157 0.1678 0.1759
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0118 0.1234 0.1284
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0333 0.2497
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0069 0.0666 0.069
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0102 0.0098
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0102 0.0746
Leishmania major oxidoreductase, putative 0.0118 0.1234 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0433 0.0445
Trypanosoma brucei Trans-2-enoyl-ACP reductase 1, putative 0.0043 0.0371 0.2819
Trypanosoma cruzi quinone oxidoreductase, putative 0.0043 0.0371 0.2841
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0171 0.0112
Loa Loa (eye worm) hypothetical protein 0.017 0.1829 0.1918
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0035 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0012
Loa Loa (eye worm) carboxylesterase 0.0012 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0069
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.1151 0.1196
Echinococcus multilocularis dna polymerase eta 0.002 0.0102 0.0093
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0171 0.3954
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0118 0.1234 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0118 0.1234 0.1267
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0012
Leishmania major DNA polymerase eta, putative 0.002 0.0102 0.0609
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0102 0.058
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0068 0.0292
Mycobacterium ulcerans hypothetical protein 0.0111 0.1151 0.1196
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0333 0.0324
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0075 0.074 0.5892
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0487 0.0478
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0118 0.1234 0.1284
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.2645 0.2638
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0118 0.1234 0.1284
Brugia malayi Metabotropic glutamate receptor precursor. 0.0041 0.0354 0.0372
Schistosoma mansoni single-minded 0.0051 0.0459 0.0472
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0322 0.0704
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0012
Brugia malayi hypothetical protein 0.017 0.1829 0.1918
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0029 0.0147
Brugia malayi Alcohol dehydrogenase class III 0.0841 0.9538 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0068 0.0058
Schistosoma mansoni hypothetical protein 0.0361 0.4019 0.4208
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0029 0.0044
Echinococcus multilocularis histone acetyltransferase MYST2 0.0113 0.1172 0.1164
Schistosoma mansoni neuroligin 3 (S09 family) 0.0012 0.0011 0.0002
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0581 0.06
Loa Loa (eye worm) hypothetical protein 0.0099 0.1015 0.1064
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0118 0.1234 1
Echinococcus multilocularis acetylcholinesterase 0.0069 0.0666 0.0658
Leishmania major hypothetical protein, conserved 0.0043 0.0371 0.2841
Onchocerca volvulus 0.0049 0.0442 0.0453
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.003
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0118 0.1234 0.1284
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0068 0.0059
Loa Loa (eye worm) beta-lactamase 0.0111 0.1151 0.1207
Loa Loa (eye worm) hypothetical protein 0.0075 0.074 0.0776
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0333 0.0119
Echinococcus granulosus BC026374 protein S09 family 0.0012 0.0011 0.0004
Toxoplasma gondii type I fatty acid synthase 0.0043 0.0371 0.0323
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0333 0.0338
Onchocerca volvulus 0.0111 0.1151 0.1196
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0102 0.0107
Echinococcus granulosus metabotropic glutamate receptor 2 0.0035 0.0277 0.0603
Mycobacterium tuberculosis Conserved protein 0.0111 0.1151 0.1196
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0102 0.0098
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0029 0.003
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0487 0.3892
Trypanosoma cruzi oxidoreductase, putative 0.0075 0.074 0.5904
Loa Loa (eye worm) hypothetical protein 0.0113 0.1172 0.1229
Echinococcus multilocularis carboxylesterase 5A 0.0069 0.0666 0.0658
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0102 0.0746
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0118 0.1234 0.2757
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.1151 0.932
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0068 0.0322
Leishmania major hypothetical protein, conserved 0.0111 0.1151 0.931
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0433 0.0445
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0065 0.0126
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0102 0.0609
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0487 0.3892
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0118 0.1234 1
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.2645 0.5935
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0333 0.0728
Echinococcus granulosus phd:f box containing protein 0.0016 0.0065 0.0126
Echinococcus granulosus carboxylesterase 5A 0.0069 0.0666 0.1479
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0102 0.058
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0398 0.4451 0.4445
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0118 0.1234 1
Brugia malayi beta-lactamase family protein 0.0111 0.1151 0.1207
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.1151 0.1207
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0102 0.058
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0118 0.1234 0.1284
Schistosoma mansoni sex comb on midleg homolog 0.0099 0.1015 0.1055
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.1151 0.1196
Onchocerca volvulus 0.0037 0.0308 0.0312
Leishmania major zinc-binding dehydrogenase-like protein 0.0075 0.074 0.5904
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0065 0.0272
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0333 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.1151 0.1198
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0102 0.0096
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0068 0.0322
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0515 0.0474
Trypanosoma brucei unspecified product 0.002 0.0102 0.058
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0065 0.0056
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0102 0.0096
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0012 0.0011 0.0002
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.1151 0.1196
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0333 0.0349
Leishmania major hypothetical protein, conserved 0.0043 0.0371 0.2841
Echinococcus granulosus cpg binding protein 0.0031 0.0233 0.0504
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0102 0.0609
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0118 0.1234 1
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0068 0.0003
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0322 0.0271
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0118 0.1234 0.1267
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0051 0.0464 0.0456
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0487 0.3802
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0118 0.1234 1
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0118 0.1234 0.1284
Brugia malayi jmjC domain containing protein 0.0016 0.0065 0.0069
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0047 0.042 0.0431
Echinococcus multilocularis synaptic vesicle membrane protein VAT 1 0.0043 0.0371 0.0362
Mycobacterium ulcerans oxidoreductase FadB5 0.0118 0.1234 0.1284
Schistosoma mansoni hypothetical protein 0.061 0.6882 0.7213
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0308 0.0323
Onchocerca volvulus 0.0029 0.0214 0.0213
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.1234 0.1284
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0322 0.0326
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0075 0.074 0.0776
Brugia malayi jmjC domain containing protein 0.0063 0.06 0.0629
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0118 0.1234 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.1151 0.1207
Mycobacterium leprae conserved hypothetical protein 0.0111 0.1151 0.118
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0118 0.1234 0.1284
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0068 0.0061
Schistosoma mansoni cpg binding protein 0.0031 0.0233 0.0235
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0065 0.0302
Trypanosoma brucei oxidoreductase, putative 0.0118 0.1234 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0433 0.0454
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0322 0.2407
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0433 0.0424
Onchocerca volvulus 0.0118 0.1234 0.1284
Brugia malayi isocitrate dehydrogenase 0.0017 0.0068 0.0071
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.1151 0.931
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0065 0.0069
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.1151 0.931
Loa Loa (eye worm) carboxylesterase 0.0012 0.0011 0.0012
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0065 0.0056
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0433 0.0454
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0333 0.5987
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0322 0.2541
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0065 0.0126
Mycobacterium ulcerans lipase LipD 0.0111 0.1151 0.1196
Leishmania major oxidoreductase-like protein 0.0118 0.1234 1
Echinococcus multilocularis acetylcholinesterase 0.0069 0.0666 0.0658
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.06 0.062
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0035 0.0046
Toxoplasma gondii type I fatty acid synthase, putative 0.0118 0.1234 0.1234
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0065 0.0059
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.1151 0.257
Mycobacterium ulcerans quinone reductase Qor 0.0118 0.1234 0.1284
Trypanosoma brucei oxidoreductase, putative 0.0118 0.1234 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.1151 0.1207
Brugia malayi CXXC zinc finger family protein 0.0029 0.0214 0.0224
Schistosoma mansoni zinc binding dehydrogenase 0.0118 0.1234 0.1285
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0459 0.0472
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0322 0.2541
Echinococcus granulosus para nitrobenzyl esterase 0.0012 0.0011 0.0004
Echinococcus granulosus polycomb protein SCMH1 0.0099 0.1015 0.2264
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0035 0.0046
Loa Loa (eye worm) hypothetical protein 0.002 0.0102 0.0107
Trypanosoma cruzi oxidoreductase, putative 0.0043 0.0371 0.2841
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0118 0.1234 0.1284
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0118 0.1234 0.1284
Loa Loa (eye worm) oxidoreductase 0.0043 0.0371 0.0389
Trypanosoma cruzi quinone oxidoreductase, putative 0.0043 0.0371 0.2841
Schistosoma mansoni gliotactin 0.0012 0.0011 0.0002
Loa Loa (eye worm) hypothetical protein 0.0118 0.1234 0.1294
Schistosoma mansoni ap endonuclease 0.004 0.0333 0.0339
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0029 0.0147
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0322 0.194
Onchocerca volvulus 0.0099 0.1015 0.1054
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.1151 0.1196
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0029 0.002
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0487 0.3802
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0011 0.0002
Onchocerca volvulus 0.0075 0.074 0.0766
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0102 0.0096
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.06 0.0629
Trypanosoma brucei protein kinase, putative 0.0053 0.0487 0.3783
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0118 0.1234 0.1294
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0068 0.0131
Mycobacterium ulcerans polyketide synthase 0.0118 0.1234 0.1284
Brugia malayi hypothetical protein 0.0016 0.0067 0.007
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0118 0.1234 1
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.1151 0.1196
Leishmania major nuclear receptor binding factor-like protein 0.0075 0.074 0.5904
Loa Loa (eye worm) hypothetical protein 0.0111 0.1151 0.1207
Schistosoma mansoni inositol monophosphatase 0.0039 0.0322 0.0328
Brugia malayi mbt repeat family protein 0.0099 0.1015 0.1064
Echinococcus granulosus acetylcholinesterase 0.0069 0.0666 0.1479
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0068 0.0322
Echinococcus granulosus dna polymerase eta 0.002 0.0102 0.0209
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0102 0.058
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0075 0.074 0.0776
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0012 0.0011 0.0004
Mycobacterium ulcerans quinone oxidoreductase 0.0118 0.1234 0.1284
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0029 0.0147
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0065 0.0056
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0118 0.1234 0.1294
Loa Loa (eye worm) hypothetical protein 0.0111 0.1151 0.1207
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0487 0.3783
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0029 0.0147
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0102 0.058
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0013 0.0029 0.0147
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0043 0.0371 0.0389
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0102 0.0609
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0841 0.9538 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0102 0.058
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0099 0.1015 0.1055
Echinococcus granulosus dna polymerase kappa 0.002 0.0102 0.0209
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0841 0.9538 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0113 0.1172 0.1164
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0487 0.3892
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0118 0.1234 0.1267
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0118 0.1234 0.1284
Trichomonas vaginalis adenylate cyclase, putative 0.0013 0.0029 0.0147
Loa Loa (eye worm) glutamate receptor 0.0041 0.0354 0.0372
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0065 0.0059
Loa Loa (eye worm) hypothetical protein 0.0118 0.1234 0.1294
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0841 0.9538 1
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0038 0.031 0.0325
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0118 0.1234 0.1284
Brugia malayi Cytochrome P450 family protein 0.0046 0.0404 0.0424
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0029 0.0044
Toxoplasma gondii exonuclease III APE 0.004 0.0333 0.0282
Leishmania major hypothetical protein, conserved 0.0016 0.0065 0.0302
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0029 0.002
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0075 0.074 0.0766
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0068 0.0058
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0333 0.2463
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0487 0.0501
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0118 0.1234 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0433 0.0424
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0171 0.1179
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0118 0.1234 0.1284
Brugia malayi beta-lactamase family protein 0.0111 0.1151 0.1207
Leishmania major protein kinase, putative 0.0014 0.0035 0.0046
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0118 0.1234 0.1284
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0085 0.0169
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0065 0.0059
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0029 0.0147
Leishmania major quinone oxidoreductase-like protein,alcohol dehydrogenase, zinc-containing-like protein 0.0043 0.0371 0.2841
Onchocerca volvulus 0.0013 0.0029 0.0019
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0322 0.243
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0102 0.0107
Loa Loa (eye worm) hypothetical protein 0.0069 0.0666 0.0699
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0333 0.252
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0333 0.252
Schistosoma mansoni alcohol dehydrogenase 0.0841 0.9538 1
Trichomonas vaginalis esterase, putative 0.0111 0.1151 0.932
Brugia malayi Inositol-1 0.0039 0.0322 0.0337
Mycobacterium tuberculosis Conserved protein 0.0111 0.1151 0.1196
Echinococcus multilocularis dna polymerase kappa 0.002 0.0102 0.0093
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.1151 0.1196
Loa Loa (eye worm) hypothetical protein 0.0111 0.1151 0.1207
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.1151 0.932
Mycobacterium leprae Probable lipase LipE 0.0111 0.1151 0.118
Loa Loa (eye worm) mbt repeat family protein 0.0099 0.1015 0.1064
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0487 0.1076
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0433 0.0954
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0322 0.0313
Echinococcus multilocularis neuroligin 0.0012 0.0011 0.0002
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0322 0.2541
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0433 0.0954
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0068 0.0058
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0065 0.0126

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 750 nM Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay ChEMBL. 11063624
IC50 (binding) = 750 nM Affinity for human neuropeptide Y receptor Y5, binding was evaluated in an in vitro radioligand [125I]-PYY binding assay ChEMBL. 11063624

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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