Detailed information for compound 281561

Basic information

Technical information
  • TDR Targets ID: 281561
  • Name: (3S,4S)-3-amino-1-hydroxy-4-methylpyrrolidin- 2-one
  • MW: 130.145 | Formula: C5H10N2O2
  • H donors: 2 H acceptors: 2 LogP: -1.07 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H]1CN(C(=O)[C@H]1N)O
  • InChi: 1S/C5H10N2O2/c1-3-2-7(9)5(8)4(3)6/h3-4,9H,2,6H2,1H3/t3-,4-/m0/s1
  • InChiKey: SKYSFPFYQBZGDC-IMJSIDKUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3S,4S)-3-amino-1-hydroxy-4-methyl-pyrrolidin-2-one
  • (3S,4S)-3-amino-1-hydroxy-4-methyl-2-pyrrolidinone
  • (3S,4S)-3-azanyl-1-hydroxy-4-methyl-pyrrolidin-2-one
  • (3S,4S)-3-amino-1-hydroxy-4-methyl-2-pyrrolidone
  • L 687414
  • 132695-96-6
  • cis-4-Methyl-HA-966
  • 2-Pyrrolidinone, 3-amino,1-hydroxy-4-methyl-, (3S-cis)-
  • L 687,414
  • L-687,414
  • L-687414

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine receptor 0.0023 0.0166 0.0334
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.005 0.0501 0.0697
Schistosoma mansoni ets-related 0.001 0.0002 0.0005
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0012 0.0027 0.0316
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0501 0.0501
Echinococcus granulosus somatostatin receptor 0.0023 0.0166 0.0231
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0286
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0027 0.0038
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0063 0.0638
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.012 0.1405
Trypanosoma cruzi cdc2-related kinase 1 0.005 0.0501 0.5858
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.029 0.1121
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0079 0.0856 0.0856
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0079 0.0856 0.119
Echinococcus granulosus nAChR subunit 0.0018 0.0102 0.0142
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0052 0.0237
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0118
Echinococcus granulosus tumor protein p63 0.0352 0.4269 0.5934
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0023 0.0166 0.0334
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0045 0.0118
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0321 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0321 0.1242
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0112 0.0395
Echinococcus granulosus tyrosine kinase 0.0014 0.0045 0.0063
Loa Loa (eye worm) hypothetical protein 0.0036 0.0321 0.0838
Echinococcus granulosus lamin 0.0054 0.0549 0.0763
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0119 0.1302
Schistosoma mansoni aldehyde dehydrogenase 0.0185 0.2185 0.4386
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0069 0.0735 0.1104
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0199 0.0277
Treponema pallidum 76K protein 0.0011 0.0009 0.0013
Echinococcus granulosus protein C ets 2 0.001 0.0002 0.0003
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0079 0.0856 0.3919
Loa Loa (eye worm) hypothetical protein 0.0049 0.0488 0.1273
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0063 0.0126
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0002 0.0006
Onchocerca volvulus 0.0018 0.0102 0.036
Echinococcus multilocularis geminin 0.0169 0.1989 0.1989
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0102 0.0142
Echinococcus granulosus leukotriene A 4 hydrolase 0.0232 0.2777 0.386
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0321 0.1242
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.001 0 0.5
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0112 0.0293
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0102 0.0266
Plasmodium falciparum transporter, putative 0.0015 0.0063 0.0638
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0012 0.0027 0.0054
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0321 0.0838
Loa Loa (eye worm) hypothetical protein 0.0019 0.0112 0.0293
Onchocerca volvulus 0.0051 0.0516 0.1818
Echinococcus granulosus serotonin transporter 0.0015 0.0063 0.0087
Echinococcus multilocularis glutamate receptor 2 0.0027 0.0209 0.0209
Echinococcus multilocularis bloom syndrome protein 0.002 0.012 0.012
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0027 0.0209 0.0209
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0363 0.724
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0002 0.0006
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0102 0.0266
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0102 0.0395
Schistosoma mansoni nuclear receptor 0.0017 0.0084 0.0169
Loa Loa (eye worm) doublecortin family protein 0.002 0.0119 0.031
Brugia malayi PAN domain containing protein 0.0014 0.0052 0.0201
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.001 0 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0084 0.0117
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0119 0.0165
Echinococcus multilocularis expressed protein 0.0373 0.4534 0.4534
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0164
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0286
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0363 0.1279
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0023 0.0166 0.0166
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.029 0.0756
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0166 0.0231
Onchocerca volvulus 0.0023 0.0166 0.0586
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Loa Loa (eye worm) melatonin receptor type 1A 0.0023 0.0166 0.0434
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0363 0.4241
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0363 0.0363
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0102 0.0395
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0102 0.0102
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0027 0.0209 0.0209
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0166 0.0434
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0102 0.0395
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0052 0.0135
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0235 0.0908
Entamoeba histolytica type A flavoprotein, putative 0.003 0.0249 0.4964
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0321 0.0838
Brugia malayi hypothetical protein 0.0012 0.0027 0.0105
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.012 0.0167
Entamoeba histolytica hypothetical protein 0.0019 0.0112 0.2237
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0647 0.1299
Brugia malayi PAN domain containing protein 0.0014 0.0052 0.0201
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0549 0.1431
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0023 0.0166 0.0334
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0363 0.4878
Schistosoma mansoni adenoreceptor 0.0023 0.0166 0.0334
Echinococcus granulosus nmda type glutamate receptor 0.0191 0.2261 0.3143
Schistosoma mansoni hypothetical protein 0.0169 0.1989 0.3993
Plasmodium vivax SET domain protein, putative 0.003 0.0253 0.2888
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0025 0.0187 0.0487
Echinococcus granulosus glutamate receptor subunit protein glur 0.0027 0.0209 0.0291
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0009 0.0034
Brugia malayi hypothetical protein 0.002 0.0119 0.046
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0112 0.0293
Brugia malayi nuclear receptor NHR-88 0.0017 0.0084 0.0326
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.011 0.011
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0166 0.0231
Loa Loa (eye worm) CUTiclin-Like family member 0.0011 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0036 0.0321 0.0838
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0079 0.0856 1
Brugia malayi sulfakinin receptor protein 0.0023 0.0166 0.0643
Schistosoma mansoni glutamate receptor NMDA 0.0136 0.1572 0.3155
Schistosoma mansoni glutamate receptor kainate 0.0027 0.0209 0.042
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0102 0.0395
Onchocerca volvulus 0.0023 0.0166 0.0586
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0023 0.0166 0.0586
Brugia malayi follicle stimulating hormone receptor 0.0023 0.0166 0.0643
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.015 0.1664
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0321 0.0321
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0501 0.0501
Brugia malayi CXXC zinc finger family protein 0.0029 0.0231 0.0895
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0363 0.1662
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0012 0.0027 0.0316
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0257 0.3083 0.4286
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0069 0.0735 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0321 0.0447
Echinococcus granulosus voltage dependent calcium channel subunit 0.0266 0.3202 0.4452
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.012 0.1616
Echinococcus granulosus geminin 0.0169 0.1989 0.2765
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus multilocularis receptor type guanylyl cyclase 0.0014 0.0045 0.0045
Giardia lamblia Nitric oxide synthase, inducible 0.007 0.0744 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0135
Entamoeba histolytica type A flavoprotein, putative 0.003 0.0249 0.4964
Schistosoma mansoni hypothetical protein 0.0027 0.0209 0.042
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0112 0.0395
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0125 0.0327
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0012 0.0027 0.0095
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0125 0.0485
Echinococcus granulosus serotonin receptor 0.0023 0.0166 0.0231
Echinococcus granulosus sex peptide receptor 0.0023 0.0166 0.0231
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0166 0.0231
Loa Loa (eye worm) hypothetical protein 0.0036 0.0321 0.0838
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0166 0.0166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0321 0.0838
Onchocerca volvulus 0.0011 0.0009 0.0031
Onchocerca volvulus 0.0018 0.0102 0.036
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0166 0.0231
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0166 0.0166
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.005 0.0501 0.2296
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0166 0.0166
Echinococcus granulosus neuropeptide receptor 0.0023 0.0166 0.0231
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0112 0.0225
Brugia malayi PXA domain containing protein 0.0019 0.0112 0.0434
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0027 0.0209 0.0291
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0052 0.0237
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0321 0.0645
Brugia malayi Pre-SET motif family protein 0.0209 0.248 0.9585
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0119 0.1302
Brugia malayi Dopamine receptor protein 1 0.0023 0.0166 0.0643
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0135
Schistosoma mansoni ets 0.001 0.0002 0.0005
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.011 0.022
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0102 0.0395
Schistosoma mansoni hypothetical protein 0.0037 0.0341 0.0684
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0023 0.0166 0.0166
Brugia malayi von Willebrand factor type A domain containing protein 0.0011 0.0009 0.0034
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0112 0.0112
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0253 0.0509
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0166 0.0334
Onchocerca volvulus 0.0014 0.0052 0.0183
Loa Loa (eye worm) glutamate receptor 1 0.0027 0.0209 0.0545
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0501 0.1007
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0363 0.4182
Onchocerca volvulus 0.0011 0.0009 0.0031
Schistosoma mansoni myosin xvIII 0.0023 0.0166 0.0334
Loa Loa (eye worm) aminopeptidase N 0.0012 0.0027 0.0071
Echinococcus multilocularis lamin 0.0054 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0071
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0027 0.0027
Onchocerca volvulus 0.0012 0.0027 0.0095
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0063 0.0126
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0164
Brugia malayi hypothetical protein 0.0037 0.0341 0.1317
Onchocerca volvulus 0.0014 0.0052 0.0183
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0102 0.0142
Schistosoma mansoni hypothetical protein 0.0023 0.0166 0.0334
Plasmodium vivax amine transporter, putative 0.0015 0.0063 0.0638
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Brugia malayi GnHR receptor homolog 0.0023 0.0166 0.0643
Onchocerca volvulus 0.0023 0.0166 0.0586
Brugia malayi larval opioid receptor 0.0023 0.0166 0.0643
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0112 0.0225
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0166 0.0166
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0253 0.0509
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0321 0.0321
Schistosoma mansoni protein kinase 0.0014 0.0045 0.0091
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0027 0.0209 0.0209
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0166 0.0231
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0232 0.0322
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0232 0.2777 0.7241
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0501 0.1308
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0166 0.0334
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0069 0.0735 0.3363
Brugia malayi nuclear receptor NHR-67 0.0017 0.0084 0.0326
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0052 0.0237
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Echinococcus multilocularis aminopeptidase N 0.0012 0.0027 0.0027
Brugia malayi Zona pellucida-like domain containing protein 0.0011 0.0009 0.0034
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0112 0.0156
Echinococcus granulosus glutamate receptor 2 0.0014 0.0045 0.0063
Schistosoma mansoni rotamase 0.0033 0.029 0.0582
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0027 0.0209 0.0291
Brugia malayi putative neuropeptide receptor NPR1 0.0023 0.0166 0.0643
Echinococcus granulosus dnaJ subfamily B 0.0409 0.4981 0.6925
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0012 0.0027 0.0316
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0321 0.0645
Echinococcus granulosus orexin receptor type 2 0.0023 0.0166 0.0231
Schistosoma mansoni neuropeptide receptor 0.0023 0.0166 0.0334
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0112 0.0434
Trypanosoma brucei aminopeptidase, putative 0.0012 0.0027 0.0316
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.012 0.1317
Echinococcus granulosus allatostatin A receptor 0.0023 0.0166 0.0231
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0112 0.0112
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0102 0.0142
Loa Loa (eye worm) hypothetical protein 0.002 0.012 0.0314
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0102 0.0102
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0166 0.0231
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0512 0.5938
Schistosoma mansoni growth hormone secretagogue receptor 0.0023 0.0166 0.0334
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0023 0.0166 0.0434
Brugia malayi PAN domain containing protein 0.0014 0.0052 0.0201
Brugia malayi PAN domain containing protein 0.0014 0.0052 0.0201
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0014 0.0045 0.0175
Brugia malayi Protein kinase domain containing protein 0.005 0.0501 0.1938
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0063 0.0288
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0166 0.0231
Schistosoma mansoni ATP-binding cassette transporter 0.0027 0.0209 0.042
Leishmania major hypothetical protein, conserved 0.0022 0.015 0.0685
Echinococcus granulosus neuropeptide receptor 0.0023 0.0166 0.0231
Giardia lamblia Kinase, CMGC CDK 0.005 0.0501 0.6738
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0166 0.0231
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0321 0.0447
Entamoeba histolytica type A flavoprotein, putative 0.003 0.0249 0.4964
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0253 0.0253
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0112 0.0156
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0079 0.0856 1
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0079 0.0856 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0102 0.0395
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0232 0.2777 0.5575
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0027 0.0038
Echinococcus granulosus metabotropic glutamate receptor 5 0.0014 0.0045 0.0063
Onchocerca volvulus 0.002 0.0119 0.0419
Schistosoma mansoni glutamate receptor AMPA 0.0027 0.0209 0.042
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0041 0.0381 0.0381
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0027 0.0038
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0321 0.0645
Brugia malayi ecdysone receptor 0.0017 0.0084 0.0326
Schistosoma mansoni intermediate filament proteins 0.0054 0.0549 0.1102
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.028 0.1282
Schistosoma mansoni hypothetical protein 0.0022 0.015 0.0301
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Brugia malayi G protein-coupled receptor 0.0023 0.0166 0.0643
Loa Loa (eye worm) FAD binding domain-containing protein 0.0049 0.048 0.1252
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0119 0.0119
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0063 0.0087
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0164
Onchocerca volvulus 0.0011 0.0009 0.0031
Brugia malayi ecdysteroid receptor 0.0036 0.0321 0.1242
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0015 0.0063 0.0063
Echinococcus granulosus neuropeptide receptor A26 0.0023 0.0166 0.0231
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.012 0.0465
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0063 0.0087
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0023 0.0166 0.0166
Trichomonas vaginalis rotamase, putative 0.0033 0.029 0.1021
Echinococcus multilocularis lamin dm0 0.0054 0.0549 0.0549
Toxoplasma gondii hypothetical protein 0.0015 0.0063 0.0288
Trypanosoma cruzi p450 reductase, putative 0.0079 0.0856 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0501 0.1766
Toxoplasma gondii PAN/Apple domain-containing protein 0.0014 0.0052 0.0237
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.012 0.0424
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0166 0.0166
Schistosoma mansoni coup transcription factor 0.0036 0.0321 0.0645
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0069 0.0735 0.3363
Brugia malayi Receptor family ligand binding region containing protein 0.0014 0.0045 0.0175
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0112 0.0112
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0023 0.0166 0.0434
Brugia malayi G-protein coupled receptor 0.0023 0.0166 0.0643
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0112 0.0225
Onchocerca volvulus 0.0018 0.0102 0.036
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0102 0.0266
Schistosoma mansoni amine GPCR 0.0023 0.0166 0.0334
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0166 0.0334
Toxoplasma gondii microneme protein MIC17B 0.0014 0.0052 0.0237
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0084 0.0169
Toxoplasma gondii microneme protein MIC4 0.0014 0.0052 0.0237
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.031
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0014 0.0045 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0321 0.1242
Trichomonas vaginalis set domain proteins, putative 0.0237 0.2839 1
Brugia malayi Melatonin receptor type 1A 0.0023 0.0166 0.0643
Echinococcus granulosus glutamate receptor 2 0.0041 0.0381 0.053
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.015 0.1664
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0166 0.0166
Echinococcus multilocularis glutamate receptor 2 0.0014 0.0045 0.0045
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.011 0.0153
Onchocerca volvulus 0.0023 0.0166 0.0586
Toxoplasma gondii microneme protein MIC17C 0.0014 0.0052 0.0237
Echinococcus granulosus metabotropic glutamate receptor 2 0.0014 0.0045 0.0063
Onchocerca volvulus 0.0023 0.0166 0.0586
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0024 0.0175 0.0677
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.012 0.1405
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0015 0.0063 0.0243
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0102 0.0142
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0049 0.048 0.0964
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.001 0 0.5
Echinococcus multilocularis methionine synthase reductase 0.0049 0.048 0.048
Brugia malayi hypothetical protein 0.0023 0.0166 0.0643
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0256 0.3066 0.6156
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0027 0.0209 0.0291
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0084 0.0169
Onchocerca volvulus 0.0054 0.0549 0.1933
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0166 0.0231
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0041 0.0381 0.053
Echinococcus granulosus pikachurin 0.0024 0.0175 0.0244
Onchocerca volvulus 0.0014 0.0052 0.0183
Brugia malayi conserved hypotetical protein 0.0017 0.0084 0.0326
Onchocerca volvulus 0.0011 0.0009 0.0031
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0363 0.0505
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0023 0.0166 0.0434
Echinococcus multilocularis G protein coupled receptor 139 0.0023 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.007 0.0744 0.2622
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0023 0.0166 0.0231
Brugia malayi PAN domain containing protein 0.0014 0.0052 0.0201
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0166 0.0434
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0363 0.1662
Onchocerca volvulus 0.0023 0.0166 0.0586
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0125 0.0174
Loa Loa (eye worm) flavodoxin family protein 0.003 0.0249 0.0649
Brugia malayi PAN domain containing protein 0.0014 0.0052 0.0201
Loa Loa (eye worm) peptidase family M1 containing protein 0.0012 0.0027 0.0071
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0166 0.0166
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0012 0.0027 0.0054
Echinococcus granulosus tachykinin peptides receptor 99D 0.0023 0.0166 0.0231
Schistosoma mansoni nAChR subunit 0.0018 0.0102 0.0205
Loa Loa (eye worm) hypothetical protein 0.0019 0.0112 0.0293
Schistosoma mansoni metabotropic glutamate receptor 0.0014 0.0045 0.0091
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Loa Loa (eye worm) hypothetical protein 0.0036 0.0321 0.0838
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Echinococcus multilocularis g-protein coupled receptor 0.0023 0.0166 0.0166
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0041 0.0381 0.0381
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0321 0.0447
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0102 0.0395
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0166 0.0231
Onchocerca volvulus 0.0023 0.0166 0.0586
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Onchocerca volvulus 0.0015 0.0063 0.0221
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0321 0.1132
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0118
Brugia malayi Ets-domain containing protein 0.0072 0.0767 0.2964
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0166 0.0334
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus granulosus 7TM GPCR rhodopsin 0.0023 0.0166 0.0231
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0015 0.0066 0.0132
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Loa Loa (eye worm) hypothetical protein 0.0079 0.0856 0.2232
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0321 0.0447
Toxoplasma gondii aldehyde dehydrogenase 0.0185 0.2185 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Onchocerca volvulus 0.0011 0.0009 0.0031
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0052 0.0135
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0023 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.0321 0.0838
Brugia malayi hypothetical protein 0.0019 0.011 0.0424
Trypanosoma brucei cdc2-related kinase 1 0.005 0.0501 0.5858
Schistosoma mansoni hypothetical protein 0.0023 0.0166 0.0334
Echinococcus granulosus g protein coupled receptor 0.0023 0.0166 0.0231
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0002 0.0002
Brugia malayi nuclear receptor RXR 0.0019 0.011 0.0424
Entamoeba histolytica hypothetical protein 0.0014 0.0045 0.09
Schistosoma mansoni aminopeptidase A (M01 family) 0.0012 0.0027 0.0054
Loa Loa (eye worm) hypothetical protein 0.0019 0.0112 0.0293
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0253 0.0509
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Schistosoma mansoni gabp alpha 0.0072 0.0767 0.154
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0012 0.0027 0.0216
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0363 0.4241
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.012 0.0551
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0027 0.0038
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0023 0.0166 0.0334
Entamoeba histolytica hypothetical protein 0.0011 0.0009 0.0174
Schistosoma mansoni cpg binding protein 0.003 0.0252 0.0506
Brugia malayi Metabotropic glutamate receptor precursor. 0.0014 0.0045 0.0175
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0094 0.1042 0.1042
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0041 0.0381 0.053
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0363 0.4241
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Entamoeba histolytica hypothetical protein, conserved 0.0011 0.0009 0.0174
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0166 0.0166
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.015 0.0208
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0063 0.0063
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.012 0.1317
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0102 0.0266
Brugia malayi Kringle domain containing protein 0.0022 0.015 0.0579
Loa Loa (eye worm) hypothetical protein 0.003 0.0253 0.0661
Onchocerca volvulus 0.0017 0.0084 0.0297
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0079 0.0856 0.0856
Brugia malayi hypothetical protein 0.0023 0.0166 0.0643
Echinococcus granulosus hypothetical protein 0.0023 0.0166 0.0231
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0501 0.1766
Loa Loa (eye worm) hypothetical protein 0.0036 0.0321 0.0838
Echinococcus multilocularis somatostatin receptor 0.0023 0.0166 0.0166
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0562 0.0782
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0118
Onchocerca volvulus 0.0022 0.015 0.0527
Brugia malayi hypothetical protein 0.0107 0.1208 0.4668
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0011 0.0009 0.0023
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0102 0.0266
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0512 0.598
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0166 0.0166
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0015 0.0063 0.0063
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.012 0.0167
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0006
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0063 0.0126
Loa Loa (eye worm) hypothetical protein 0.0053 0.0536 0.1399
Brugia malayi Bloom's syndrome protein homolog 0.002 0.012 0.0465
Brugia malayi Dopamine receptor 0.0023 0.0166 0.0643
Brugia malayi Ets-domain containing protein 0.001 0.0002 0.001
Echinococcus granulosus neuropeptide FF receptor 2 0.0023 0.0166 0.0231
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.015 0.015
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.015 0.039
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0079 0.0856 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0102 0.0142
Echinococcus multilocularis sex peptide receptor 0.0023 0.0166 0.0166
Brugia malayi PAN domain containing protein 0.0014 0.0052 0.0201
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0084 0.0084
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0112 0.0434
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0321 0.0447
Loa Loa (eye worm) serotonin transporter b 0.0015 0.0063 0.0164
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0027 0.0124
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0102 0.0142
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0084 0.022
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.005 0.0501 0.2296
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Schistosoma mansoni hypothetical protein 0.0169 0.1989 0.3993
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0023 0.0166 0.0334
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0102 0.0266
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0012 0.0027 0.0316
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0321 0.0645
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0084 0.022
Schistosoma mansoni lipoxygenase 0.002 0.0119 0.0239
Onchocerca volvulus 0.0023 0.0166 0.0586
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0363 0.0546
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0321 0.0447
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0112 0.0112
Brugia malayi hypothetical protein 0.0023 0.0166 0.0643
Treponema pallidum flavodoxin 0.003 0.0249 0.0374
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0512 0.5938
Leishmania major extracellular receptor, putative 0.0014 0.0045 0.0207
Echinococcus granulosus RUN 0.002 0.0119 0.0165
Brugia malayi G-protein coupled receptor 0.0023 0.0166 0.0643
Onchocerca volvulus 0.0012 0.0027 0.0095
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0166 0.0231
Brugia malayi Tachykinin-like peptides receptor 99D 0.0023 0.0166 0.0643
Toxoplasma gondii microneme protein MIC17A 0.0014 0.0052 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0112 0.0395
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0321 0.1132
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.012 0.0551
Brugia malayi von Willebrand factor type A domain containing protein 0.0011 0.0009 0.0034
Brugia malayi hypothetical protein 0.0017 0.0084 0.0326
Loa Loa (eye worm) hypothetical protein 0.0019 0.0112 0.0293
Loa Loa (eye worm) hypothetical protein 0.0036 0.0321 0.0838
Loa Loa (eye worm) RecQ helicase 0.002 0.012 0.0314
Schistosoma mansoni hypothetical protein 0.0011 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Schistosoma mansoni neuropeptide receptor 0.0023 0.0166 0.0334
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0011 0.0009 0.004
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0257 0.3083 0.3083
Plasmodium falciparum amino acid transporter, putative 0.0015 0.0063 0.0638
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0166 0.0434
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0012 0.0027 0.0216
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0102 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0321 0.1242
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0063 0.0063
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0012 0.0027 0.0316
Toxoplasma gondii flavodoxin domain-containing protein 0.0039 0.0361 0.1651
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0002 0.0006
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0166 0.0166
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0102 0.0205
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0012 0.0027 0.0095
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0102 0.0142
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0363 0.1403
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0023 0.0166 0.0166
Chlamydia trachomatis glutamine binding protein 0.0069 0.0735 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Schistosoma mansoni metabotropic glutamate receptor 0.0014 0.0045 0.0091
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.028 0.5585
Trichomonas vaginalis NADPH cytochrome P450, putative 0.003 0.0249 0.0877
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0321 0.0645
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.028 0.1282
Schistosoma mansoni polycystin 1-related 0.002 0.0119 0.0239
Echinococcus multilocularis serotonin receptor 0.0023 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0286
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0185 0.2185 0.3037
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0164
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0286
Schistosoma mansoni biogenic amine receptor 0.0023 0.0166 0.0334
Echinococcus multilocularis protein C ets 2 0.001 0.0002 0.0002
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.011 0.0424
Echinococcus granulosus cyclin dependent kinase 1 0.005 0.0501 0.0697
Echinococcus granulosus cyclin dependent kinase 0.005 0.0501 0.0697
Entamoeba histolytica recQ family helicase, putative 0.002 0.012 0.2399
Onchocerca volvulus Putative nachr subunit 0.0018 0.0102 0.036
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.248 0.6467
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus granulosus cpg binding protein 0.003 0.0252 0.035
Brugia malayi hypothetical protein 0.0023 0.0166 0.0643
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0549 0.2121
Echinococcus multilocularis glutamate receptor 2 0.0041 0.0381 0.0381
Toxoplasma gondii hypothetical protein 0.0014 0.0052 0.0237
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0012 0.0027 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0321 0.1242
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0084 0.0117
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0084 0.0117
Toxoplasma gondii flavodoxin domain-containing protein 0.0039 0.0361 0.1651
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0084 0.0117
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0045 0.0118
Schistosoma mansoni slit 0.0024 0.0175 0.0352
Brugia malayi EGF-like domain containing protein 0.0024 0.0175 0.0677
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0027 0.0027
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0235 0.0612
Schistosoma mansoni cell polarity protein 0.0024 0.0175 0.0352
Echinococcus multilocularis serotonin receptor 0.0023 0.0166 0.0166
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0014 0.0045 0.0118
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0767 0.0767
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0119 0.0165
Echinococcus multilocularis nAChR subunit 0.0018 0.0102 0.0102
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0549 0.1431
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0253 0.0352
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.012 0.012
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0102 0.0102
Echinococcus granulosus receptor type guanylyl cyclase 0.0014 0.0045 0.0063
Schistosoma mansoni nAChR subunit 0.0018 0.0102 0.0205
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.011 0.0286
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.012 0.0465
Brugia malayi tailless protein 0.0017 0.0084 0.0326
Echinococcus multilocularis dro:myosuppressin receptor 0.0023 0.0166 0.0166
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0012 0.0027 0.0027
Trypanosoma cruzi cdc2-related kinase 3 0.005 0.0501 0.5858
Brugia malayi Serotonin receptor 0.0023 0.0166 0.0643
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0321 0.0838
Echinococcus multilocularis orexin receptor type 2 0.0023 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0024 0.0175 0.0457
Brugia malayi Cache domain containing protein 0.0118 0.1347 0.5205
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.015 0.1749
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0027 0.0124
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.012 0.0551
Schistosoma mansoni aldehyde dehydrogenase 0.0185 0.2185 0.4386
Loa Loa (eye worm) hypothetical protein 0.0054 0.0549 0.1431
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0166 0.0334
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.028 0.3272
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0321 0.1242
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0321 0.0321
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0102 0.0395
Schistosoma mansoni hypothetical protein 0.002 0.0119 0.0239
Echinococcus multilocularis slit 2 protein 0.0024 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0118
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0014 0.0045 0.0118
Brugia malayi hypothetical protein 0.0122 0.1393 0.5384
Mycobacterium ulcerans aminopeptidase N PepN 0.0012 0.0027 0.0124
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0102 0.0266
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0002 0.001
Toxoplasma gondii microneme protein, putative 0.0014 0.0052 0.0237
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0166 0.0231
Brugia malayi PXA domain containing protein 0.0019 0.0112 0.0434
Onchocerca volvulus 0.0036 0.0321 0.1132
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0118
Echinococcus granulosus atrial natriuretic peptide receptor 0.0014 0.0045 0.0063
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0157 0.041
Brugia malayi hypothetical protein 0.0023 0.0166 0.0643
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0321 0.1242
Schistosoma mansoni amine GPCR 0.0023 0.0166 0.0334
Trichomonas vaginalis NADPH cytochrome P450, putative 0.003 0.0249 0.0877
Loa Loa (eye worm) abnormal epIthelia family member 0.0024 0.0175 0.0457
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0501 0.1007
Schistosoma mansoni alpha-1 adrenergic receptor 0.0023 0.0166 0.0334
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0041 0.0381 0.053
Brugia malayi hypothetical protein 0.0017 0.0084 0.0326
Onchocerca volvulus 0.0029 0.0231 0.0815
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0102 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0321 0.1242
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0102 0.0266
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0566 0.2591
Brugia malayi nuclear receptor RXR 0.0017 0.0084 0.0326
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0079 0.0856 1
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0012 0.0027 0.0216
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.2185 1
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0112 0.0156
Loa Loa (eye worm) hypothetical protein 0.01 0.1128 0.2941
Schistosoma mansoni ap endonuclease 0.0039 0.0363 0.0729
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0321 0.1242
Entamoeba histolytica hypothetical protein 0.0019 0.0112 0.2237
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0076 0.0153
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0166 0.0166
Schistosoma mansoni hypothetical protein 0.0257 0.3083 0.6189
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Giardia lamblia Kinase, CMGC CDK 0.005 0.0501 0.6738
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0079 0.0856 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.2185 1
Schistosoma mansoni ap endonuclease 0.0039 0.0363 0.0729
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0166 0.0334
Chlamydia trachomatis sulfite reductase 0.0049 0.048 0.6209
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0011 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0164
Loa Loa (eye worm) norepinephrine transporter 0.0015 0.0063 0.0164
Schistosoma mansoni cpg binding protein 0.003 0.0252 0.0506
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0512 0.598
Brugia malayi TATA binding protein associated factor 0.0012 0.0027 0.0105
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0166 0.0334
Entamoeba histolytica hypothetical protein 0.0019 0.0112 0.2237
Brugia malayi hypothetical protein 0.0023 0.0166 0.0643
Onchocerca volvulus 0.0023 0.0166 0.0586
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.0175 0.0244
Schistosoma mansoni elf1 0.001 0.0002 0.0005
Brugia malayi hypothetical protein 0.0019 0.0112 0.0434
Echinococcus granulosus voltage dependent calcium channel subunit 0.0586 0.7193 1
Brugia malayi metabotropic glutamate receptor type 2 0.0014 0.0045 0.0175
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0166 0.0166
Brugia malayi Glutamate receptor 2 precursor 0.0027 0.0209 0.0808
Loa Loa (eye worm) TYRA-2 protein 0.0023 0.0166 0.0434
Brugia malayi PAN domain containing protein 0.0014 0.0052 0.0201
Schistosoma mansoni amine GPCR 0.0023 0.0166 0.0334
Loa Loa (eye worm) hypothetical protein 0.0061 0.0637 0.1662
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0084 0.0169
Trichomonas vaginalis rotamase, putative 0.0033 0.028 0.0987
Entamoeba histolytica hypothetical protein 0.0037 0.0341 0.6796
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0063 0.0126
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0027 0.0038
Brugia malayi hypothetical protein 0.0014 0.0045 0.0175
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Onchocerca volvulus 0.0014 0.0045 0.0159
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0063 0.0164
Schistosoma mansoni hypothetical protein 0.0023 0.0159 0.032
Echinococcus multilocularis musashi 0.0054 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.0022 0.015 0.039
Schistosoma mansoni histamine h1 receptor 0.0023 0.0166 0.0334
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0027 0.0105
Trypanosoma brucei Aminopeptidase M1, putative 0.0012 0.0027 0.0316
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0041 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0036 0.0321 0.0838
Brugia malayi nuclear receptor NHR-88 0.0036 0.0321 0.1242
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0321 0.0447
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0011 0.0009 0.0034
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0063 0.0288
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0112 0.0156
Trypanosoma cruzi aminopeptidase, putative 0.0012 0.0027 0.0316
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0052 0.0237
Echinococcus granulosus fmrfamide receptor 0.0023 0.0166 0.0231
Schistosoma mansoni ets-related 0.0217 0.2587 0.5194
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0112 0.0293
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0125 0.0327
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.012 0.0314
Onchocerca volvulus 0.0015 0.0063 0.0221
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0084 0.0326
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0002 0.0003
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0023 0.0166 0.0231
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0023 0.0166 0.0434
Brugia malayi von Willebrand factor type A domain containing protein 0.0011 0.0009 0.0034
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0102 0.0142
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0159 0.0222
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0166 0.0231
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0063 0.0126
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0321 0.0838
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0002 0.0003
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0102 0.0142
Brugia malayi laminin alpha chain 0.0024 0.0175 0.0677
Onchocerca volvulus 0.0023 0.0166 0.0586
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0112 0.0225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0321 0.0838
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0118
Loa Loa (eye worm) hypothetical protein 0.0026 0.0199 0.0519
Loa Loa (eye worm) FAD binding domain-containing protein 0.0079 0.0856 0.2232
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0079 0.0856 0.3919
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0012 0.0027 0.0216
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0102 0.0102
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0166 0.0166
Brugia malayi G protein-coupled receptor F59B2.13 0.0023 0.0166 0.0643
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0014 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0027 0.0027
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0023 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Brugia malayi nuclear hormone receptor 0.0017 0.0084 0.0326
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0023 0.0166 0.0434
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.01 0.1128 0.1128
Trypanosoma cruzi Aminopeptidase M1, putative 0.0012 0.0027 0.0316
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0024 0.0175 0.0352
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0321 0.0645
Onchocerca volvulus 0.0014 0.0052 0.0183
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0084 0.0326
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0023 0.0166 0.0166
Schistosoma mansoni opsin-like receptor 0.0023 0.0166 0.0334
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Echinococcus multilocularis neuropeptide FF receptor 2 0.0023 0.0166 0.0166
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0586 0.7193 0.7193
Toxoplasma gondii subtilisin SUB12 0.0014 0.0052 0.0237
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0112 0.0156
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0063 0.0164
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0063 0.0243
Brugia malayi neuropeptide F receptor 0.0023 0.0166 0.0643
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0063 0.0288
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0166 0.0231
Entamoeba histolytica hypothetical protein 0.0037 0.0341 0.6796
Echinococcus multilocularis thyroid hormone receptor alpha 0.0293 0.3531 0.3531
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0112 0.0112
Schistosoma mansoni nuclear receptor 0.0017 0.0084 0.0169
Schistosoma mansoni neuropeptide receptor 0.0023 0.0166 0.0334
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0112 0.0434
Echinococcus granulosus peptide allatostatin:somatostatin 0.0023 0.0166 0.0231
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0166 0.0334
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0321 0.0645
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0063 0.0243
Schistosoma mansoni lamin 0.0054 0.0549 0.1102
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0102 0.0102
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0084 0.0084
Loa Loa (eye worm) glutamate receptor 0.0014 0.0045 0.0118
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0102 0.0205
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0012 0.0027 0.0316
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0166 0.0166
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.003 0.0249 0.2908
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.012 0.0424
Onchocerca volvulus 0.0023 0.0166 0.0586
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0266 0.3202 0.3202
Toxoplasma gondii exonuclease III APE 0.0039 0.0363 0.1662
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0112 0.0225
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0102 0.0102
Onchocerca volvulus 0.0014 0.0045 0.0159
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0119 0.0165
Onchocerca volvulus 0.0014 0.0052 0.0183
Plasmodium falciparum nitric oxide synthase, putative 0.0079 0.0856 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0102 0.0395
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0002 0.0003
Brugia malayi Fli-1 protein 0.0217 0.2587 1
Echinococcus multilocularis pikachurin 0.0024 0.0175 0.0175
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0102 0.0205
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0102 0.0142
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0002 0.0005
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0129 0.1483 0.2976
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0112 0.0225
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0084 0.0117
Schistosoma mansoni neuropeptide receptor 0.0023 0.0166 0.0334
Echinococcus granulosus aminopeptidase N 0.0012 0.0027 0.0038
Brugia malayi transcription factor E74 isoform 0.001 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0166 0.0166
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0011 0.0009 0.0031
Echinococcus granulosus bloom syndrome protein 0.002 0.012 0.0167
Loa Loa (eye worm) hypothetical protein 0.0051 0.0512 0.1335
Schistosoma mansoni NADPH flavin oxidoreductase 0.004 0.0368 0.0739
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0027 0.0124
Onchocerca volvulus 0.0015 0.0063 0.0221
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0084 0.0297
Brugia malayi putative neuropeptide receptor 0.0023 0.0166 0.0643
Trichomonas vaginalis sulfite reductase, putative 0.0079 0.0856 0.3016
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0135
Schistosoma mansoni DNA helicase recq5 0.002 0.012 0.0242
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0166 0.0334
Schistosoma mansoni hypothetical protein 0.0409 0.4981 1
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0052 0.0237
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0102 0.0395
Trypanosoma brucei Aminopeptidase M1, putative 0.0012 0.0027 0.0316
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.4981 0.4981
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0166 0.0434
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0102 0.0142
Brugia malayi RE15519p 0.0023 0.0166 0.0643
Onchocerca volvulus 0.0023 0.0166 0.0586
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0185 0.2185 1
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0166 0.0231
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.012 0.0424
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0027 0.0105
Echinococcus multilocularis neuropeptide s receptor 0.0023 0.0166 0.0166
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.1128 0.2264
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0231 0.0604
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0562 0.0562
Leishmania major cytochrome P450 reductase, putative 0.007 0.0744 0.3407
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.1128 0.2264
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Toxoplasma gondii kringle domain-containing protein 0.0022 0.015 0.0685
Echinococcus multilocularis glutamate receptor NMDA 0.0095 0.1063 0.1063
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0321 0.0838
Onchocerca volvulus 0.0237 0.2839 1
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0002 0.0006
Trichomonas vaginalis NADPH cytochrome P450, putative 0.003 0.0249 0.0877
Schistosoma mansoni cpg binding protein 0.0029 0.0231 0.0465
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0084 0.0169
Brugia malayi AKH receptor 0.0023 0.0166 0.0643
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0166 0.0231
Echinococcus multilocularis RUN 0.002 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0024 0.0175 0.0457
Onchocerca volvulus 0.0023 0.0166 0.0586
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0341 0.0341
Schistosoma mansoni nAChR subunit 0.0018 0.0102 0.0205
Entamoeba histolytica aminopeptidase, putative 0.0012 0.0027 0.054
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0079 0.0856 1
Brugia malayi hypothetical protein 0.0023 0.0166 0.0643
Brugia malayi hypothetical protein 0.002 0.0119 0.046
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0063 0.0243
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0063 0.0087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Toxoplasma gondii aminopeptidase N, putative 0.0012 0.0027 0.0124
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0164
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0112 0.0293
Echinococcus multilocularis neuropeptide receptor A26 0.0023 0.0166 0.0166
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0118
Schistosoma mansoni thyroid hormone receptor 0.0293 0.3531 0.709
Toxoplasma gondii hypothetical protein 0.0014 0.0052 0.0237
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0102 0.0102
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0011 0.0009 0.0023
Echinococcus granulosus g protein coupled receptor 0.0023 0.0166 0.0231
Entamoeba histolytica cell division protein kinase 2, putative 0.005 0.0501 1
Loa Loa (eye worm) hypothetical protein 0.01 0.1128 0.2941
Schistosoma mansoni nAChR subunit 0.0018 0.0102 0.0205
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0135
Echinococcus multilocularis nmda type glutamate receptor 0.0109 0.1235 0.1235
Loa Loa (eye worm) hypothetical protein 0.0051 0.0516 0.1346
Schistosoma mansoni nAChR subunit 0.0018 0.0102 0.0205
Echinococcus multilocularis expressed protein 0.0033 0.029 0.029
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0102 0.0395
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0023 0.0166 0.0643
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0084 0.0326
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0199 0.0199
Schistosoma mansoni thyroid hormone receptor 0.0293 0.3531 0.709
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0102 0.0205
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.028 0.3272
Brugia malayi von Willebrand factor type A domain containing protein 0.0011 0.0009 0.0034
Brugia malayi flavodoxin family protein 0.0079 0.0856 0.3309
Toxoplasma gondii aminopeptidase n, putative 0.0012 0.0027 0.0124
Brugia malayi FAD binding domain containing protein 0.0079 0.0856 0.3309
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0185 0.2185 0.2185
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0135
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0125 0.0125
Schistosoma mansoni lamin 0.0054 0.0549 0.1102
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.003 0.0249 0.2908
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0112 0.0156
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0071
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0027 0.0027
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0002 0.0003
Trypanosoma brucei cdc2-related kinase 3 0.005 0.0501 0.5858
Schistosoma mansoni cytochrome P450 reductase 0.0079 0.0856 0.1719
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.005 0.0501 0.1308
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.005 0.0501 0.2296
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus granulosus methionine synthase reductase 0.0049 0.048 0.0667
Brugia malayi Guanylyl cyclase protein 23 0.0014 0.0045 0.0175
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0321 0.1132
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0002 0.0002
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0084 0.0326
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0063 0.0087
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0166 0.0166
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0321 0.1242
Schistosoma mansoni tyrosine kinase 0.0014 0.0045 0.0091
Entamoeba histolytica hypothetical protein, conserved 0.0011 0.0009 0.0174
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0084 0.0169
Toxoplasma gondii aminopeptidase N protein 0.0012 0.0027 0.0124
Leishmania major hypothetical protein, conserved 0.003 0.0249 0.1139
Schistosoma mansoni lipoxygenase 0.0055 0.0562 0.1129
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0125 0.0252
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0112 0.0434
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0286
Brugia malayi hypothetical protein 0.0019 0.011 0.0424
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0501 0.1308
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Echinococcus granulosus dro:myosuppressin receptor 0.0023 0.0166 0.0231
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Brugia malayi hypothetical protein 0.0019 0.0112 0.0434
Onchocerca volvulus 0.0014 0.0052 0.0183
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0023 0.0166 0.0334
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0321 0.1242
Schistosoma mansoni tyrosine kinase 0.0014 0.0045 0.0091
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0516 0.1036
Echinococcus granulosus glutamate NMDA receptor subunit 0.0094 0.1042 0.1449
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0023 0.0166 0.0334
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0501 0.1766
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0023 0.0166 0.0334
Brugia malayi PAN domain containing protein 0.0014 0.0052 0.0201
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0102 0.0395
Schistosoma mansoni glutamate receptor kainate 0.0027 0.0209 0.042
Onchocerca volvulus 0.0015 0.0063 0.0221
Schistosoma mansoni hypothetical protein 0.001 0.0002 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0253 0.0509
Schistosoma mansoni diflavin oxidoreductase 0.0039 0.0361 0.0724
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0321 0.1242
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0321 0.1242
Onchocerca volvulus 0.002 0.0119 0.0419
Brugia malayi Ets-domain containing protein 0.0072 0.0767 0.2964
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0112 0.0395
Echinococcus multilocularis cyclin dependent kinase 0.005 0.0501 0.0501
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0767 0.2
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0363 0.1662
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0166 0.0334
Echinococcus granulosus 7tm_1 domain containing protein 0.0023 0.0166 0.0231
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus granulosus slit 2 protein 0.0024 0.0175 0.0244
Onchocerca volvulus 0.0014 0.0052 0.0183
Brugia malayi PAN domain containing protein 0.0014 0.0052 0.0201
Echinococcus multilocularis ets variant gene 4 0.001 0.0002 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0084 0.0084
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0084 0.0297
Brugia malayi von Willebrand factor type A domain containing protein 0.0011 0.0009 0.0034
Brugia malayi Pre-SET motif family protein 0.003 0.0253 0.098
Onchocerca volvulus 0.0023 0.0166 0.0586
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0102 0.0395
Schistosoma mansoni amine GPCR 0.0023 0.0166 0.0334
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0166 0.0231
Echinococcus multilocularis NMDA receptor 0.0027 0.0209 0.0209
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0002 0.0002
Brugia malayi hypothetical protein 0.0011 0.0009 0.0034
Echinococcus granulosus lamin dm0 0.0054 0.0549 0.0763
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0102 0.0266
Schistosoma mansoni serine-rich repeat protein 0.0138 0.1592 0.3197
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Plasmodium vivax protein kinase Crk2 0.005 0.0501 0.5815
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0363 0.1279
Brugia malayi von Willebrand factor type A domain containing protein 0.0011 0.0009 0.0034
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0119 0.0119
Onchocerca volvulus 0.0014 0.0052 0.0183
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.0175 0.0175
Onchocerca volvulus 0.0054 0.0549 0.1933
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0321 0.0645
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.011 0.0424
Brugia malayi nuclear hormone receptor 0.0036 0.0321 0.1242
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0321 0.0645
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0512 0.598
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0166 0.0334
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0166 0.0334
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0069 0.0735 0.1104
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0052 0.0237
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0023 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0071
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.003 0.0249 0.2835
Schistosoma mansoni opsin-like receptor 0.0023 0.0166 0.0334
Schistosoma mansoni nAChR subunit 0.0018 0.0102 0.0205
Onchocerca volvulus 0.0014 0.0052 0.0183
Onchocerca volvulus 0.0023 0.0166 0.0586
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.2185 1
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0079 0.0856 0.119
Entamoeba histolytica type A flavoprotein, putative 0.003 0.0249 0.4964
Echinococcus granulosus neuropeptide s receptor 0.0023 0.0166 0.0231
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0063 0.0126
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Leishmania major hypothetical protein, conserved 0.0051 0.0512 0.2343
Onchocerca volvulus 0.0018 0.0102 0.036
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Brugia malayi neuropeptide F receptor 0.0023 0.0166 0.0643
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0023 0.0166 0.0231
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0112 0.0112
Onchocerca volvulus 0.0011 0.0009 0.0031
Schistosoma mansoni biogenic amine receptor 0.0023 0.0166 0.0334
Loa Loa (eye worm) TATA binding protein associated factor 0.0012 0.0027 0.0071
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0363 0.0947
Onchocerca volvulus 0.003 0.0253 0.0893
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0112 0.0156
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.003 0.0249 0.2908
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0166 0.0166
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0023 0.0166 0.0643
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0321 0.0838
Schistosoma mansoni hypothetical protein 0.0138 0.1592 0.3197
Entamoeba histolytica hypothetical protein 0.0037 0.0341 0.6796
Trypanosoma cruzi extracellular receptor, putative 0.0014 0.0045 0.0527
Onchocerca volvulus 0.0014 0.0052 0.0183
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.028 0.3272
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0542 0.6652 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0363 1
Echinococcus multilocularis nmda type glutamate receptor 0.0191 0.2261 0.2261
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.1128 0.2264
Treponema pallidum sodium- and chloride- dependent transporter 0.0015 0.0063 0.0094
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0102 0.0395
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0119 0.0119
Echinococcus multilocularis allatostatin A receptor 0.0023 0.0166 0.0166
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0096 0.1071 0.1071
Treponema pallidum hypothetical protein 0.0011 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0317 0.3835 1
Schistosoma mansoni hypothetical protein 0.0011 0.0009 0.0018
Brugia malayi hypothetical protein 0.0023 0.0166 0.0643
Schistosoma mansoni hypothetical protein 0.0023 0.0166 0.0334
Loa Loa (eye worm) hypothetical protein 0.0025 0.0187 0.0487
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0135
Loa Loa (eye worm) solute carrier family 6 member 4 0.0015 0.0063 0.0164
Onchocerca volvulus 0.0014 0.0052 0.0183
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0052 0.0135
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0166 0.0334
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0112 0.0395
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0166 0.0334
Brugia malayi ORL1-like opioid receptor 0.0023 0.0166 0.0643
Schistosoma mansoni hypothetical protein 0.001 0.0002 0.0005
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0014 0.0045 0.0045
Onchocerca volvulus 0.0012 0.0027 0.0095
Brugia malayi Cation transporter family protein 0.0018 0.0102 0.0395
Echinococcus granulosus g protein coupled receptor 0.0023 0.0166 0.0231
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0321 0.0321
Brugia malayi hypothetical protein 0.0015 0.0063 0.0243
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0084 0.0084
Toxoplasma gondii hypothetical protein 0.0015 0.0063 0.0288
Echinococcus granulosus expressed protein 0.0373 0.4534 0.6304
Brugia malayi flavodoxin family protein 0.003 0.0249 0.0962
Echinococcus granulosus collagen alpha 1VII chain 0.0011 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Entamoeba histolytica hypothetical protein 0.0037 0.0341 0.6796
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus granulosus G protein coupled receptor 139 0.0023 0.0166 0.0231
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0102 0.0142
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0112 0.0156
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0164
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0159 0.0159
Schistosoma mansoni rab6-interacting 0.002 0.0119 0.0239
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0166 0.0166
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0125 0.0252
Onchocerca volvulus 0.0018 0.0102 0.036
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0052 0.0135
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0112 0.0225
Schistosoma mansoni glutamate receptor AMPA 0.0027 0.0209 0.042
Loa Loa (eye worm) hypothetical protein 0.0118 0.1347 0.3512
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0041 0.0381 0.053
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0112 0.0112
Echinococcus granulosus expressed protein 0.0033 0.029 0.0403
Schistosoma mansoni opsin-like receptor 0.0023 0.0166 0.0334
Giardia lamblia Hypothetical protein 0.007 0.0744 1
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0014 0.0045 0.0118
Schistosoma mansoni rab6-interacting 0.002 0.0119 0.0239
Echinococcus granulosus cyclin dependent kinase 5 0.005 0.0501 0.0697
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.01 0.1128 0.1568
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0102 0.0395
Schistosoma mansoni amine GPCR 0.0023 0.0166 0.0334
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0015 0.0063 0.0087
Brugia malayi Receptor family ligand binding region containing protein 0.0014 0.0045 0.0175
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Schistosoma mansoni loxhd1 0.002 0.0119 0.0239
Echinococcus granulosus g-protein coupled receptor 0.0023 0.0166 0.0231
Brugia malayi cell division control protein 2 homolog 0.005 0.0501 0.1938
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0112 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0321 0.1242
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0232 0.2777 0.2777
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0112 0.0225
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0052 0.0135
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Schistosoma mansoni DNA helicase recq1 0.002 0.012 0.0242
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0102 0.0205
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0321 0.1242
Brugia malayi hypothetical protein 0.0051 0.0512 0.1979
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0014 0.0052 0.0237
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0166 0.0334
Echinococcus granulosus glutamate receptor NMDA 0.0095 0.1063 0.1478
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0166 0.0334
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0102 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0112 0.0395
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0321 0.0447
Echinococcus granulosus nmda type glutamate receptor 0.0109 0.1235 0.1717
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.029 0.1021
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0512 0.5938
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0084 0.0326
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0166 0.0231
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0023 0.0166 0.0334
Onchocerca volvulus 0.0023 0.0166 0.0586
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0002 0.0003
Loa Loa (eye worm) DR-78 0.0017 0.0084 0.022
Loa Loa (eye worm) hypothetical protein 0.0024 0.0175 0.0457
Onchocerca volvulus 0.0017 0.0084 0.0297
Brugia malayi Glutamate receptor 1 precursor 0.0027 0.0209 0.0808
Schistosoma mansoni glutamate receptor NMDA 0.0094 0.1042 0.2092
Onchocerca volvulus 0.0018 0.0102 0.036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0166 0.0166
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0084 0.0326
Brugia malayi Cation transporter family protein 0.0018 0.0102 0.0395
Brugia malayi Serotonin receptor 0.0023 0.0166 0.0643
Plasmodium falciparum protein kinase 5 0.005 0.0501 0.5815
Brugia malayi Zona pellucida-like domain containing protein 0.0011 0.0009 0.0034
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0102 0.0395
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0253 0.0253
Echinococcus multilocularis tumor protein p63 0.0352 0.4269 0.4269
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0002 0.0002
Echinococcus granulosus alpha 1A adrenergic receptor 0.0023 0.0166 0.0231
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Onchocerca volvulus 0.0011 0.0009 0.0031
Loa Loa (eye worm) glutamate receptor 2 0.0027 0.0209 0.0545
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0341 0.0684
Echinococcus multilocularis cpg binding protein 0.003 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0027 0.0124
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0084 0.022
Trypanosoma cruzi cdc2-related kinase 3 0.005 0.0501 0.5858
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0166 0.0166
Brugia malayi hypothetical protein 0.0012 0.0027 0.0105
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0045 0.0118
Brugia malayi von Willebrand factor type A domain containing protein 0.0011 0.0009 0.0034
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0063 0.0243
Mycobacterium ulcerans aminopeptidase N PepN 0.0012 0.0027 0.0124
Onchocerca volvulus Neuropeptide F receptor homolog 0.0023 0.0166 0.0586
Schistosoma mansoni neuropeptide f receptor 76f 0.0023 0.0166 0.0334
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0512 0.2343
Schistosoma mansoni nAChR subunit 0.0018 0.0102 0.0205
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0166 0.0231
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Brugia malayi laminin-like protein K08C7.3 precursor 0.0024 0.0175 0.0677
Brugia malayi FAD binding domain containing protein 0.0049 0.048 0.1855
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0112 0.0434
Trypanosoma cruzi cdc2-related kinase 1 0.005 0.0501 0.5858
Trichomonas vaginalis NADPH cytochrome P450, putative 0.003 0.0249 0.0877
Brugia malayi von Willebrand factor type A domain containing protein 0.0011 0.0009 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0125 0.0252
Brugia malayi Cytochrome P450 family protein 0.0023 0.0157 0.0608
Echinococcus multilocularis serotonin transporter 0.0015 0.0063 0.0063
Echinococcus multilocularis cyclin dependent kinase 5 0.005 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Entamoeba histolytica type A flavoprotein, putative 0.003 0.0249 0.4964
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0321 0.0447
Plasmodium vivax hypothetical protein, conserved 0.003 0.0249 0.2835
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0023 0.0166 0.0643
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0135
Brugia malayi hypothetical protein 0.0033 0.0285 0.1103
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.003 0.0249 0.2835
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.012 0.012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0166 0.0166
Brugia malayi Protein kinase domain containing protein 0.0022 0.015 0.0579
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0102 0.0395
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0112 0.0395
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0014 0.0045 0.0159
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0118
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0027 0.0027
Echinococcus multilocularis G-protein coupled receptor, putative 0.0023 0.0166 0.0166
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0023 0.0166 0.0643
Schistosoma mansoni sodium-dependent amino acid transporter 0.0015 0.0063 0.0126
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0023 0.0166 0.0643
Brugia malayi Doublecortin family protein 0.002 0.0119 0.046
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0112 0.0112
Onchocerca volvulus 0.0023 0.0166 0.0586
Brugia malayi hypothetical protein 0.0023 0.0166 0.0643
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0767 0.1066
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0041 0.0381 0.0381
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0112 0.0112
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0027 0.0105
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0027 0.0038
Loa Loa (eye worm) fli-1 protein 0.0217 0.2587 0.6747
Loa Loa (eye worm) CUTiclin family member 0.0011 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0164
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Entamoeba histolytica cell division protein kinase 2, putative 0.005 0.0501 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0063 0.0126
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0023 0.0166 0.0334
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.011 0.022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0118
Echinococcus granulosus intermediate filament protein 0.0054 0.0549 0.0763
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0185 0.2185 1
Leishmania major p450 reductase, putative 0.0079 0.0856 0.3919
Toxoplasma gondii microneme protein MIC2 0.0011 0.0009 0.004
Plasmodium vivax flavodoxin domain containing protein 0.007 0.0744 0.8681
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0341 0.0474
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0063 0.0126
Brugia malayi intermediate filament protein 0.0054 0.0549 0.2121
Echinococcus multilocularis tyrosine kinase 0.0014 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0019 0.0112 0.0293
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0084 0.0084
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0079 0.0856 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0321 0.0321
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.0175 0.0352
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.003 0.0249 0.2908
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0166 0.0334
Brugia malayi steroid hormone receptor 0.0036 0.0321 0.1242
Brugia malayi von Willebrand Factor 0.0011 0.0009 0.0034
Brugia malayi Cation transporter family protein 0.0018 0.0102 0.0395
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0102 0.0142
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0006
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0084 0.0117
Schistosoma mansoni zinc finger protein 0.0017 0.0084 0.0169
Schistosoma mansoni glutamate receptor kainate 0.0027 0.0209 0.042
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0102 0.0205
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Schistosoma mansoni regulator of G protein signaling 0.0021 0.013 0.026
Entamoeba histolytica elongation factor-2 kinase, putative 0.0011 0.0009 0.0174
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0321 0.0645
Trypanosoma cruzi aminopeptidase, putative 0.0012 0.0027 0.0316
Brugia malayi Dopamine receptor protein 2 0.0023 0.0166 0.0643
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0166 0.0334
Brugia malayi hypothetical protein 0.0023 0.0166 0.0643
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0112 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0321 0.1242
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0363 0.4182
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0253 0.116

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 86 uM Inhibition of [3H]-glycine binding to rat cortical membranes ChEMBL. No reference
IC50 (binding) = 86 uM Inhibition of [3H]-glycine binding to rat cortical membranes ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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