Detailed information for compound 284833

Basic information

Technical information
  • TDR Targets ID: 284833
  • Name: [6-amino-2-(4-methoxyphenyl)-4H-thieno[2,3-d] [1,3]dithiin-5-yl]-naphthalen-1-ylmethanone
  • MW: 449.608 | Formula: C24H19NO2S3
  • H donors: 1 H acceptors: 1 LogP: 7.06 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C1SCc2c(S1)sc(c2C(=O)c1cccc2c1cccc2)N
  • InChi: 1S/C24H19NO2S3/c1-27-16-11-9-15(10-12-16)23-28-13-19-20(22(25)29-24(19)30-23)21(26)18-8-4-6-14-5-2-3-7-17(14)18/h2-12,23H,13,25H2,1H3
  • InChiKey: NZLXLHJQGKUDBB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [6-amino-2-(4-methoxyphenyl)-4H-thieno[2,3-d][1,3]dithiin-5-yl]-(1-naphthyl)methanone
  • [6-amino-2-(4-methoxyphenyl)-4H-thieno[2,3-d][1,3]dithiin-5-yl]-(1-naphthalenyl)methanone
  • [6-azanyl-2-(4-methoxyphenyl)-4H-thieno[2,3-d][1,3]dithiin-5-yl]-naphthalen-1-yl-methanone
  • [6-amino-2-(4-methoxyphenyl)-4H-thieno[5,4-d][1,3]dithiin-5-yl]-naphthalen-1-ylmethanone
  • [6-amino-2-(4-methoxyphenyl)-4H-thieno[5,4-d][1,3]dithiin-5-yl]-(1-naphthyl)methanone
  • [6-amino-2-(4-methoxyphenyl)-4H-thieno[5,4-d][1,3]dithiin-5-yl]-naphthalen-1-yl-methanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0167 0.0231
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0789 0.0789
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0026 0.0276 0.0778
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0052
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0878 0.0878
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.016 0.016
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0447 0.063
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0012 0.0062 0.0062
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0012 0.0062 0.0062
Mycobacterium ulcerans hypothetical protein 0.0025 0.0253 0.1173
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.016 0.016
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0105 0.1447 0.1447
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0125 0.0266
Trypanosoma brucei heat shock protein, putative 0.0026 0.0276 0.0386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0125 0.027
Echinococcus granulosus BC026374 protein S09 family 0.0012 0.0052 0.0052
Onchocerca volvulus 0.0012 0.0062 0.0056
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0052 0.0052
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0482 0.0679
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0253 0.1173
Schistosoma mansoni rab6-interacting 0.0039 0.0464 0.0464
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0049 0.0619 0.0619
Leishmania major heat shock protein 83-1 0.0026 0.0276 0.0267
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0878 0.1245
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.0062 0.0062
Leishmania major cathepsin L-like protease 0.0016 0.0125 0.0048
Entamoeba histolytica heat shock protein 90, putative 0.0026 0.0276 0.0603
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.044 0.044
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0105 0.1447 0.2056
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0012 0.0062 0.0052
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0815 0.1155
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0012 0.0062 0.008
Brugia malayi hypothetical protein 0.0019 0.016 0.0221
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0476 0.7013 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0447 0.0989
Loa Loa (eye worm) cysteine protease 0.0016 0.0125 0.0142
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0012 0.0062 0.0052
Loa Loa (eye worm) nuclear receptor NHR-67 0.0049 0.0619 0.0849
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0105 0.1447 0.2056
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0188 0.026
Onchocerca volvulus 0.0012 0.0052 0.0025
Loa Loa (eye worm) hypothetical protein 0.0039 0.0464 0.0627
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0815 0.1155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0125 0.027
Brugia malayi PXA domain containing protein 0.0019 0.016 0.0221
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.076 0.076
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.076 0.076
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0012 0.0052 0.0108
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0643 0.0909
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0125 0.027
Echinococcus multilocularis nAChR subunit 0.0012 0.0062 0.0062
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0125 0.027
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0125 0.2575
Leishmania major developmentally regulated phosphoprotein-like protein 0.0476 0.7013 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0049 0.0619 0.0875
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0815 0.1155
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0059 0.076 0.076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0125 0.027
Schistosoma mansoni axis inhibition protein axin 0.0019 0.016 0.016
Echinococcus granulosus cathepsin L 0.0008 0.0006 0.0006
Onchocerca volvulus 0.0012 0.0062 0.0056
Leishmania major cathepsin L-like protease 0.0062 0.0815 0.1045
Mycobacterium tuberculosis Conserved protein 0.0038 0.0447 0.1266
Trypanosoma brucei unspecified product 0.001 0.0026 0.0028
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0253 0.1173
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0468 0.0651
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0026 0.0276 0.07
Plasmodium falciparum heat shock protein 90 0.0026 0.0276 0.5846
Echinococcus granulosus para nitrobenzyl esterase 0.0012 0.0052 0.0052
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0447 0.1266
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0055 0.0709 0.0709
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0049 0.0619 0.0619
Schistosoma mansoni ferritin 0.0008 0.0004 0.0004
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0092 0.0094
Mycobacterium tuberculosis Conserved protein 0.0038 0.0447 0.1266
Brugia malayi Carboxylesterase family protein 0.0068 0.0901 0.1278
Brugia malayi Carboxylesterase family protein 0.0012 0.0052 0.0066
Echinococcus granulosus Nuclear hormone receptor HR96 0.0049 0.0619 0.0619
Mycobacterium ulcerans lipase LipD 0.0038 0.0447 0.2085
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0038
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0026 0.0276 0.0608
Schistosoma mansoni nAChR subunit 0.0012 0.0062 0.0062
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0026 0.0276 0.0386
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0166 0.2373 0.3379
Brugia malayi Probable DNA topoisomerase II 0.0026 0.0276 0.0386
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0026 0.0276 0.0778
Mycobacterium ulcerans DNA gyrase subunit B 0.0026 0.0276 0.1281
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0326 0.0326
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0026 0.0276 0.0858
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0105 0.1447 0.2056
Schistosoma mansoni nAChR subunit 0.0012 0.0062 0.0062
Brugia malayi nuclear hormone receptor 0.0049 0.0619 0.0875
Echinococcus granulosus glycine receptor subunit beta 0.0059 0.076 0.076
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0242 0.3506 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0619 0.0849
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0847 0.1092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0326 0.0326
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0092 0.0092
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0847 0.0847
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0026 0.0276 0.0276
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.2064 0.2064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0052
Plasmodium vivax heat shock protein 86, putative 0.0026 0.0276 0.5239
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0125 0.0245
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0012 0.0062 0.0062
Plasmodium vivax DNA gyrase subunit B, putative 0.0026 0.0276 0.5239
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0026 0.0026
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0847 0.1201
Brugia malayi Carboxylesterase family protein 0.0012 0.0052 0.0066
Schistosoma mansoni hypothetical protein 0.04 0.5878 0.5878
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0012 0.0062 0.0062
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0026 0.0276 0.0778
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0125 0.017
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0232 0.1073
Schistosoma mansoni thyroid hormone receptor 0.0105 0.1447 0.1447
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.3347 0.3347
Trichomonas vaginalis esterase, putative 0.0038 0.0447 0.0989
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0105 0.1447 0.2056
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0026 0.0276 0.1281
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0052
Loa Loa (eye worm) hypothetical protein 0.0019 0.016 0.0193
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0044 0.0054
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0052 0.0662 0.0662
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0125 0.027
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.016 0.016
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0055 0.0709 0.0709
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.016 0.016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0125 0.027
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0522 0.1759
Onchocerca volvulus 0.003 0.0326 0.0852
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0232 0.0203
Loa Loa (eye worm) hypothetical protein 0.0019 0.0159 0.019
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0062 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.4488 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0052
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0643 0.1057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0125 0.027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0006 0.0005
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0734 0.1039
Onchocerca volvulus 0.0016 0.0125 0.0245
Echinococcus granulosus heat shock protein 0.0026 0.0276 0.0276
Brugia malayi nuclear hormone receptor family member nhr-6 0.0049 0.0619 0.0875
Leishmania major heat shock protein 83-1 0.0026 0.0276 0.0267
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0468 1
Loa Loa (eye worm) ACC-1 protein 0.0012 0.0062 0.0052
Brugia malayi beta-lactamase family protein 0.0038 0.0447 0.063
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0125 0.2575
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0052
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0026 0.0026
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0643 0.0643
Schistosoma mansoni nuclear receptor nhr-48 0.0049 0.0619 0.0619
Onchocerca volvulus Putative nachr subunit 0.0012 0.0062 0.0056
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0026
Brugia malayi orphan nuclear receptor NR2E1 0.0049 0.0619 0.0875
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0522 0.0522
Loa Loa (eye worm) heat shock protein 90 0.0026 0.0276 0.0358
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0878 0.0878
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0012 0.0062 0.0062
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0643 0.0643
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0026 0.0276 0.07
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0447 0.1266
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.213 0.6072
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0815 0.1155
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0059 0.076 0.076
Trichomonas vaginalis sensor histidine kinase, putative 0.0026 0.0276 0.0608
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0026 0.0276 0.1281
Schistosoma mansoni BC026374 protein (S09 family) 0.0012 0.0052 0.0052
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0012 0.0062 0.0062
Onchocerca volvulus 0.0233 0.3362 1
Echinococcus granulosus ecdysone induced protein 78C 0.0105 0.1447 0.1447
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0847 0.1176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0125 0.027
Loa Loa (eye worm) hypothetical protein 0.0232 0.3347 0.4754
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0847 0.1201
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0447 0.1266
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0012 0.0062 0.0052
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0055 0.0707 0.0975
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0232 0.8372
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0125 0.027
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0447 0.8551
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0052 0.0662 0.0936
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0044 0.0089
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.016 0.035
Loa Loa (eye worm) hypothetical protein 0.0025 0.0253 0.0325
Loa Loa (eye worm) RGS-3 protein 0.0019 0.016 0.0193
Brugia malayi Steroid receptor seven-up type 2 0.0105 0.1447 0.2056
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0026 0.0276 0.1281
Trypanosoma brucei developmentally regulated phosphoprotein 0.0476 0.7013 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0125 0.2575
Loa Loa (eye worm) hypothetical protein 0.0059 0.076 0.1051
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0232 0.0696
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.0619 0.0619
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0232 0.1073
Loa Loa (eye worm) hypothetical protein 0.0025 0.0253 0.0325
Brugia malayi Cathepsin L-like precursor 0.0016 0.0125 0.017
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0055 0.0707 0.0707
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0447 0.063
Echinococcus granulosus expressed protein 0.0008 0.0004 0.0004
Leishmania major heat shock protein 83-1 0.0026 0.0276 0.0267
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0052
Schistosoma mansoni cpg binding protein 0.003 0.0324 0.0324
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0105 0.1447 0.1447
Trichomonas vaginalis receptor histidine kinase, putative 0.0026 0.0276 0.0608
Loa Loa (eye worm) acetylcholinesterase 1 0.0068 0.0901 0.1253
Onchocerca volvulus 0.0016 0.0125 0.0245
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0464 0.0464
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0062 0.008
Loa Loa (eye worm) carboxylesterase 0.0012 0.0052 0.0038
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0052 0.0662 0.0662
Loa Loa (eye worm) RNA binding protein 0.0067 0.0878 0.122
Onchocerca volvulus 0.0012 0.0052 0.0025
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0055 0.0709 0.1574
Leishmania major heat shock protein 83-1 0.0026 0.0276 0.0267
Schistosoma mansoni polycystin 1-related 0.0039 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0019 0.0159 0.019
Schistosoma mansoni endoplasmin 0.0026 0.0276 0.0276
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0062 0.008
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0447 0.0447
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0062 0.008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0105 0.1447 0.2056
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0447 0.1266
Brugia malayi cathepsin L-like precursor 0.0011 0.0044 0.0054
Schistosoma mansoni endoplasmin 0.0026 0.0276 0.0276
Echinococcus multilocularis cathepsin L 0.0008 0.0006 0.0006
Trichomonas vaginalis cdc25c, putative 0.0055 0.0709 0.1574
Loa Loa (eye worm) nuclear hormone receptor 0.0049 0.0619 0.0849
Echinococcus multilocularis RUN 0.0039 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0039 0.0464 0.0627
Loa Loa (eye worm) hypothetical protein 0.0049 0.0619 0.0849
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0012 0.0062 0.0062
Echinococcus multilocularis heat shock protein 0.0026 0.0276 0.0276
Trypanosoma brucei heat shock protein 90, putative 0.0026 0.0276 0.0386
Loa Loa (eye worm) hypothetical protein 0.003 0.0335 0.0443
Echinococcus granulosus cathepsin l1 0.0011 0.0044 0.0044
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0643 0.1426
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.016 0.0193
Trypanosoma brucei Heat shock protein 83, putative 0.0026 0.0276 0.0386
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0253 0.0712
Schistosoma mansoni nAChR subunit 0.0012 0.0062 0.0062
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0052 0.0052
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0522 0.1156
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0847 0.1201
Schistosoma mansoni retinoic acid receptor RXR 0.0201 0.2892 0.2892
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0167 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0105 0.1447 0.2056
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0643 0.0643
Schistosoma mansoni steroid hormone receptor ad4bp 0.0105 0.1447 0.1447
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.0052 0.0052
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0026 0.0276 0.1281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0125 0.027
Loa Loa (eye worm) hypothetical protein 0.0068 0.0901 0.1253
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0901 0.0901
Loa Loa (eye worm) hypothetical protein 0.0055 0.0707 0.0975
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.016 0.016
Loa Loa (eye worm) TOPoisomerase family member 0.0026 0.0276 0.0358
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0476 0.7013 0.7013
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.016 0.0221
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0276 0.5239
Loa Loa (eye worm) carboxylesterase 0.0068 0.0901 0.1253
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0052
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0105 0.1447 0.1447
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0643 0.1426
Brugia malayi Carboxylesterase family protein 0.0012 0.0052 0.0066
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0159 0.0729
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.016 0.016
Brugia malayi TAR-binding protein 0.0067 0.0878 0.1245
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0447 0.0989
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0476 0.7013 0.7013
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0276 0.0386
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0026 0.0276 1
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0026 0.0276 0.0386
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0055 0.0707 0.0707
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0049 0.0619 0.0849
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0901 0.0901
Mycobacterium ulcerans carboxylesterase, LipT 0.0012 0.0052 0.0227
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0253 0.1173
Entamoeba histolytica deoxycytidyl transferase, putative 0.0014 0.0092 0.0191
Loa Loa (eye worm) endoplasmin 0.0026 0.0276 0.0358
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0026 0.0276 0.0778
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0062 0.008
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0232 0.1073
Trichomonas vaginalis endoplasmin, putative 0.0026 0.0276 0.0608
Brugia malayi Cathepsin L-like precursor 0.0016 0.0125 0.017
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0707 0.1001
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0482 0.0679
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0878 0.122
Onchocerca volvulus 0.0012 0.0062 0.0056
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0125 0.027
Onchocerca volvulus 0.0084 0.1132 0.3281
Brugia malayi tailless protein 0.0049 0.0619 0.0875
Brugia malayi conserved hypotetical protein 0.0049 0.0619 0.0875
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0012 0.0062 0.0062
Trypanosoma brucei protein kinase, putative 0.0051 0.0643 0.0909
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0038
Echinococcus multilocularis carboxylesterase 5A 0.0068 0.0901 0.0901
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0125 0.0125
Onchocerca volvulus Bile acid receptor homolog 0.0105 0.1447 0.4227
Loa Loa (eye worm) hypothetical protein 0.0019 0.016 0.0193
Echinococcus multilocularis cysteine protease 0.0016 0.0125 0.0125
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0026 0.0276 0.0778
Brugia malayi Rhodanese-like domain containing protein 0.0055 0.0709 0.1004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0105 0.1447 0.1447
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0026 0.0276 0.0386
Loa Loa (eye worm) hypothetical protein 0.0038 0.0447 0.0603
Brugia malayi Pre-SET motif family protein 0.0204 0.2941 0.4189
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0105 0.1447 0.1447
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0643 0.0643
Echinococcus granulosus axis inhibition protein axin 0.0019 0.016 0.016
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0125 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0125 0.027
Echinococcus granulosus RUN 0.0039 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0052
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0643 0.0909
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0105 0.1447 0.2056
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0447 0.2085
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0482 0.0679
Leishmania major DNA polymerase kappa, putative 0.0021 0.0188 0.014
Onchocerca volvulus 0.0012 0.0052 0.0025
Toxoplasma gondii heat shock protein HSP90 0.0026 0.0276 0.0858
Schistosoma mansoni ferritin 0.0008 0.0004 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0253 0.1173
Leishmania major hypothetical protein, conserved 0.0026 0.0276 0.0267
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0055 0.0709 0.1574
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0012 0.0062 0.008
Echinococcus multilocularis dna polymerase eta 0.0014 0.0092 0.0092
Echinococcus granulosus cpg binding protein 0.003 0.0324 0.0324
Schistosoma mansoni nuclear hormone receptor 0.0049 0.0619 0.0619
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0193 0.277 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0012 0.0062 0.008
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.213 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0105 0.1447 0.1447
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0125 0.0125
Plasmodium falciparum endoplasmin, putative 0.0026 0.0276 0.5846
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0643 0.1426
Onchocerca volvulus Protein ultraspiracle homolog 0.0105 0.1447 0.4227
Brugia malayi beta-lactamase family protein 0.0038 0.0447 0.063
Onchocerca volvulus 0.0012 0.0062 0.0056
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.1132 0.1132
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0188 0.0527
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0253 0.1173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0815 0.1155
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0026 0.0276 0.0858
Mycobacterium ulcerans two component regulator - sensor kinase 0.0026 0.0276 0.1281
Schistosoma mansoni survival motor neuron protein 0.0047 0.0587 0.0587
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0188 0.014
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0026 0.0276 0.0386
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.213 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0049 0.0619 0.0875
Leishmania major heat shock protein 83-1 0.0026 0.0276 0.0267
Brugia malayi ecdysteroid receptor 0.0105 0.1447 0.2056
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0276 0.0386
Brugia malayi photoreceptor-specific nuclear receptor 0.0105 0.1447 0.2056
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.016 0.0221
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0062 0.008
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0447 0.0603
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0143 0.0399
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.4488 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0049 0.0619 0.1732
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0143 0.0399
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0232 0.4886
Onchocerca volvulus 0.0055 0.0709 0.2006
Plasmodium vivax vivapain-2 0.0016 0.0125 0.2308
Schistosoma mansoni nAChR subunit 0.0012 0.0062 0.0062
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0232 0.0509
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0482 0.1066
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0253 0.1173
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0143 0.0399
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0643 0.0909
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0038
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0062 0.008
Mycobacterium tuberculosis Carboxylesterase LipT 0.0012 0.0052 0.0138
Brugia malayi Cathepsin L-like precursor 0.0016 0.0125 0.017
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0308 0.4488 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0044 0.0089
Plasmodium falciparum DNA gyrase subunit B 0.0026 0.0276 0.5846
Loa Loa (eye worm) hypothetical protein 0.0105 0.1447 0.2033
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0253 0.0353
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.1132 0.1132
Loa Loa (eye worm) hypothetical protein 0.0016 0.0125 0.0142
Brugia malayi Endoplasmin precursor 0.0026 0.0276 0.0386
Loa Loa (eye worm) hypothetical protein 0.0105 0.1447 0.2033
Entamoeba histolytica hypothetical protein 0.0019 0.016 0.0345
Loa Loa (eye worm) hypothetical protein 0.0051 0.0645 0.0886
Onchocerca volvulus 0.0016 0.0125 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.016 0.035
Leishmania major cathepsin L-like protease 0.0016 0.0125 0.0048
Echinococcus multilocularis cpg binding protein 0.003 0.0324 0.0324
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0049 0.0619 0.1732
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0012 0.0062 0.008
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0012 0.0062 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.4488 1
Trichomonas vaginalis receptor histidine kinase, putative 0.0026 0.0276 0.0608
Echinococcus multilocularis ecdysone induced protein 78C 0.0105 0.1447 0.1447
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.076 0.076
Loa Loa (eye worm) hypothetical protein 0.0105 0.1447 0.2033
Schistosoma mansoni rab6-interacting 0.0039 0.0464 0.0464
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0026 0.0276 0.0778
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.016 0.016
Brugia malayi Pre-SET motif family protein 0.003 0.0326 0.0457
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.016 0.016
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0447 0.063
Onchocerca volvulus 0.0055 0.0709 0.2006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0125 0.027
Echinococcus multilocularis dnaJ subfamily B 0.04 0.5878 0.5878
Loa Loa (eye worm) hypothetical protein 0.0476 0.7013 1
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0167 0.0167
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.2064 0.2937
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0326 0.0326
Brugia malayi hypothetical protein 0.0055 0.0707 0.1001
Echinococcus granulosus cathepsin l1 0.0016 0.0125 0.0125
Brugia malayi hypothetical protein 0.0039 0.0464 0.0654
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.2003 0.2003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0747 0.2584
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0012 0.0052 0.0138
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0253 0.0233
Echinococcus granulosus carboxylesterase 5A 0.0068 0.0901 0.0901
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.016 0.016
Brugia malayi nuclear receptor NHR-88 0.0105 0.1447 0.2056
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0052
Entamoeba histolytica heat shock protein 90, putative 0.0026 0.0276 0.0603
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0707 0.1001
Leishmania major cathepsin L-like protease 0.0062 0.0815 0.1045
Onchocerca volvulus 0.0038 0.0447 0.1215
Loa Loa (eye worm) hypothetical protein 0.0049 0.0619 0.0849
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0482 0.1066
Toxoplasma gondii DNA topoisomerase 2, putative 0.0026 0.0276 0.0858
Schistosoma mansoni ferritin light chain 0.0008 0.0004 0.0004
Entamoeba histolytica DNA topoisomerase II, putative 0.0026 0.0276 0.0603
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0166 0.2373 0.3379
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0482 0.0679
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0055 0.0709 0.1574
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0026 0.0276 0.0608
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0232 0.0651
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0159 0.3305
Schistosoma mansoni regulator of G protein signaling 0.0019 0.016 0.016
Trypanosoma brucei heat shock protein, putative 0.0026 0.0276 0.0386
Echinococcus granulosus neuroligin 0.0012 0.0052 0.0052
Schistosoma mansoni ferritin light chain 0.0008 0.0004 0.0004
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0447 0.0989
Onchocerca volvulus 0.0038 0.0447 0.1215
Mycobacterium ulcerans hypothetical protein 0.0038 0.0447 0.2085
Loa Loa (eye worm) fibroinase 0.0016 0.0125 0.0142
Trypanosoma cruzi DNA topoisomerase II, putative 0.0026 0.0276 0.0386
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0232 0.0696
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0464 0.0464
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0253 0.0353
Schistosoma mansoni pyruvate dehydrogenase 0.0476 0.7013 0.7013
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.016 0.035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0125 0.027
Loa Loa (eye worm) hypothetical protein 0.0055 0.0707 0.0975
Leishmania major heat shock protein 83-1 0.0026 0.0276 0.0267
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0815 0.1155
Echinococcus granulosus glycine receptor subunit beta 0.0059 0.076 0.076
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0464 0.0464
Entamoeba histolytica hypothetical protein 0.0024 0.0232 0.0504
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0026 0.0276 0.0608
Onchocerca volvulus 0.0038 0.0447 0.1215
Trichomonas vaginalis cdc25b, putative 0.0055 0.0709 0.1574
Loa Loa (eye worm) beta-lactamase 0.0038 0.0447 0.0603
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0253 0.0552
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0105 0.1447 0.2056
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.016 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.016 0.035
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0125 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0125 0.027
Brugia malayi hypothetical protein 0.0039 0.0464 0.0654
Trypanosoma brucei unspecified product 0.0034 0.0385 0.0541
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0125 0.0125
Leishmania major DNA topoisomerase ii 0.0026 0.0276 0.0267
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0125 0.027
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0012 0.0062 0.0062
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0012 0.0062 0.0062
Schistosoma mansoni cpg binding protein 0.0028 0.03 0.03
Brugia malayi nuclear receptor NHR-67 0.0049 0.0619 0.0875
Loa Loa (eye worm) hypothetical protein 0.0038 0.0447 0.0603
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0059 0.076 0.1051
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0012 0.0062 0.008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0105 0.1447 0.1447
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0105 0.1447 0.2056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0815 0.1155
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0326 0.0326
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0012 0.0062 0.0062
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0092 0.0092
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0482 0.0679
Loa Loa (eye worm) hypothetical protein 0.0053 0.0676 0.093
Brugia malayi Carboxylesterase family protein 0.0012 0.0052 0.0066
Schistosoma mansoni nuclear hormone receptor 0.0049 0.0619 0.0619
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0476 0.7013 0.7013
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0026 0.0276 0.1281
Echinococcus granulosus nAChR subunit 0.0012 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0052
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0012 0.0062 0.0062
Brugia malayi nuclear receptor RXR 0.0049 0.0619 0.0875
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.076 0.076
Giardia lamblia Fructose-bisphosphate aldolase 0.0308 0.4488 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0645 0.0886
Onchocerca volvulus 0.0055 0.0709 0.2006
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0159 0.0442
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.016 0.016
Mycobacterium ulcerans two component sensor kinase MprB 0.0026 0.0276 0.1281
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0052
Loa Loa (eye worm) hypothetical protein 0.0026 0.0276 0.0358
Echinococcus granulosus dna polymerase kappa 0.004 0.0482 0.0482
Brugia malayi Nuclear hormone receptor-like 1 0.0105 0.1447 0.2056
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.1132 0.1132
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0052 0.0662 0.091
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0482 0.0679
Onchocerca volvulus 0.0049 0.0619 0.1732
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0878 0.0878
Echinococcus multilocularis thyroid hormone receptor alpha 0.0105 0.1447 0.1447
Schistosoma mansoni gliotactin 0.0012 0.0052 0.0052
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0878 0.122
Onchocerca volvulus 0.0028 0.03 0.0774
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.2941 0.4172
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0012 0.0062 0.008
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0276 0.0386
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0464 0.9907
Treponema pallidum fructose-bisphosphate aldolase 0.0308 0.4488 1
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0026 0.0276 0.0778
Loa Loa (eye worm) hypothetical protein 0.0049 0.0619 0.0849
Loa Loa (eye worm) LGC-31 protein 0.0012 0.0062 0.0052
Schistosoma mansoni pyruvate dehydrogenase 0.045 0.6616 0.6616
Loa Loa (eye worm) ACC-1 protein 0.0012 0.0062 0.0052
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0125 0.0125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0815 0.1155
Leishmania major heat shock protein 83-1 0.0026 0.0276 0.0267
Loa Loa (eye worm) hypothetical protein 0.0055 0.0709 0.0979
Echinococcus multilocularis dna polymerase kappa 0.004 0.0482 0.0482
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0815 0.1155
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.0619 0.0619
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0012 0.0062 0.008
Schistosoma mansoni apoferritin-2 0.0008 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0068 0.0901 0.1253
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0447 0.0989
Schistosoma mansoni regulator of G protein signaling 0.0019 0.016 0.016
Plasmodium falciparum DNA topoisomerase 2 0.0026 0.0276 0.5846
Loa Loa (eye worm) hypothetical protein 0.0019 0.0159 0.019
Schistosoma mansoni pyruvate dehydrogenase 0.045 0.6616 0.6616
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0024 0.0026
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0052
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0026 0.0276 0.0608
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0026 0.0276 0.0386
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0012 0.0052 0.0052
Brugia malayi Cation transporter family protein 0.0012 0.0062 0.008
Leishmania major heat shock protein 83-1 0.0026 0.0276 0.0267
Loa Loa (eye worm) hypothetical protein 0.0025 0.0253 0.0325
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0052
Echinococcus multilocularis cysteine protease 0.0016 0.0125 0.0125
Loa Loa (eye worm) acetyltransferase 0.0146 0.2064 0.2917
Echinococcus granulosus FTZ F1 alpha 0.0105 0.1447 0.1447
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0012 0.0052 0.0052
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0055 0.0709 0.1574
Echinococcus granulosus tar DNA binding protein 0.0067 0.0878 0.0878
Onchocerca volvulus 0.0016 0.0125 0.0245
Echinococcus multilocularis expressed protein 0.0365 0.5354 0.5354
Echinococcus granulosus geminin 0.0336 0.4919 0.4919
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0464 0.0627
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0847 0.1878
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0012 0.0062 0.0052
Brugia malayi Doublecortin family protein 0.0039 0.0464 0.0654
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0125 0.0142
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0026 0.0276 1
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0815 0.1155
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0468 0.1032
Loa Loa (eye worm) hypothetical protein 0.0014 0.0092 0.0094
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0167 0.0203
Mycobacterium leprae Probable two-component sensor kinase 0.0026 0.0276 0.1281
Leishmania major mitochondrial DNA topoisomerase II 0.0026 0.0276 0.0267
Schistosoma mansoni acetylcholinesterase 0.0012 0.0052 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.016 0.035
Brugia malayi nuclear receptor NHR-88 0.0049 0.0619 0.0875
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0447 0.0447
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.0707 0.0707
Loa Loa (eye worm) hypothetical protein 0.0019 0.016 0.0193
Brugia malayi Cation transporter family protein 0.0059 0.076 0.1076
Leishmania major heat shock protein 83-1 0.0026 0.0276 0.0267
Entamoeba histolytica rodhanase-like domain containing protein 0.0055 0.0709 0.157
Onchocerca volvulus 0.0012 0.0052 0.0025
Brugia malayi beta-lactamase 0.0038 0.0447 0.063
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0482 0.2247
Brugia malayi steroid hormone receptor 0.0105 0.1447 0.2056
Leishmania major cathepsin L-like protease 0.0062 0.0815 0.1045
Loa Loa (eye worm) hypothetical protein 0.0019 0.016 0.0193
Loa Loa (eye worm) hypothetical protein 0.0055 0.0707 0.0975
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0006 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0335 0.047
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.016 0.016
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0847 0.0847
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.4488 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.1447 0.2033
Plasmodium vivax DNA topoisomerase II, putative 0.0026 0.0276 0.5239
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0482 0.0679
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0125 0.0125
Schistosoma mansoni nAChR subunit 0.0012 0.0062 0.0062
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0464 0.0464
Brugia malayi hypothetical protein 0.0232 0.3347 0.4769
Entamoeba histolytica hypothetical protein 0.0019 0.016 0.0345
Echinococcus granulosus dna polymerase eta 0.0014 0.0092 0.0092
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0276 0.0386
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0122 0.0166
Echinococcus granulosus acetylcholinesterase 0.0068 0.0901 0.0901
Schistosoma mansoni loxhd1 0.0039 0.0464 0.0464
Entamoeba histolytica rodhanase-like domain containing protein 0.0055 0.0709 0.157
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0038
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0643 0.2203
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0482 0.0679
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0847 0.1201
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.016 0.0221
Schistosoma mansoni lipoxygenase 0.0039 0.0464 0.0464
Schistosoma mansoni thyroid hormone receptor 0.0105 0.1447 0.1447
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0026 0.0276 0.1281
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0105 0.1447 0.2033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0019 0.016 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0125 0.027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0815 0.1155
Schistosoma mansoni apoferritin-2 0.0008 0.0004 0.0004
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0049 0.0619 0.0619
Schistosoma mansoni nuclear hormone receptor 0.0105 0.1447 0.1447
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0253 0.1173
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0166 0.2373 0.3296
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0125 0.027
Loa Loa (eye worm) hypothetical protein 0.0049 0.0619 0.0849
Entamoeba histolytica hypothetical protein 0.0019 0.016 0.0345
Plasmodium vivax SET domain protein, putative 0.003 0.0326 0.6212
Mycobacterium ulcerans beta-lactamase 0.0038 0.0447 0.2085
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0643 0.0909
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.016 0.016
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0026 0.0276 0.0608
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0301 0.0301
Toxoplasma gondii ABC1 family protein 0.0038 0.0447 0.1485
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0105 0.1447 0.1447
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0464 0.888
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0105 0.1447 0.1447
Brugia malayi hypothetical protein 0.0049 0.0619 0.0875
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0026 0.0276 0.0608
Loa Loa (eye worm) hypothetical protein 0.0049 0.0619 0.0849
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0049 0.0619 0.0619
Loa Loa (eye worm) hypothetical protein 0.0055 0.0707 0.0975
Echinococcus multilocularis heat shock protein 90 0.0026 0.0276 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0125 0.027
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0232 0.0322
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0026 0.0276 0.1281
Trypanosoma cruzi DNA polymerase eta, putative 0.0014 0.0092 0.0122
Chlamydia trachomatis DNA gyrase subunit B 0.0026 0.0276 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0815 0.1155
Brugia malayi kinase, mitochondrial precursor 0.0476 0.7013 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.03 0.0393
Brugia malayi Cathepsin L-like precursor 0.0011 0.0044 0.0054
Trypanosoma brucei heat shock protein, putative 0.0026 0.0276 0.0386
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.016 0.0221
Loa Loa (eye worm) steroid hormone receptor 0.0105 0.1447 0.2033
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0385 0.0541
Schistosoma mansoni microtubule-associated protein tau 0.0676 1 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0159 0.2962
Schistosoma mansoni lipoxygenase 0.0109 0.1516 0.1516
Loa Loa (eye worm) hypothetical protein 0.0049 0.0619 0.0849
Schistosoma mansoni nAChR subunit 0.0012 0.0062 0.0062
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0105 0.1447 0.1447
Leishmania major heat shock protein 83-1 0.0026 0.0276 0.0267
Echinococcus granulosus ferritin 0.0008 0.0004 0.0004
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0012 0.0062 0.008
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.3347 0.3347
Echinococcus granulosus heat shock protein 90 0.0026 0.0276 0.0276
Schistosoma mansoni regulator of G protein signaling 0.0019 0.016 0.016
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0447 0.1266
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0167 0.0203
Trypanosoma brucei heat shock protein 90, putative 0.0026 0.0276 0.0386
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0464 0.0464
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0006 0.0006
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0026 0.0276 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0707 0.0975
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.016 0.016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0125 0.027
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0092 0.0092
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0012 0.0052 0.0138
Echinococcus granulosus dnaJ subfamily B 0.04 0.5878 0.5878
Schistosoma mansoni axis inhibition protein axin 0.0019 0.016 0.016
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0482 0.0679
Toxoplasma gondii heat shock protein 90, putative 0.0026 0.0276 0.0858
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0012 0.0062 0.0062
Brugia malayi CXXC zinc finger family protein 0.0028 0.03 0.0421
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0326 0.1042
Schistosoma mansoni regulator of G protein signaling 0.0019 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0105 0.1447 0.2033
Plasmodium vivax endoplasmin, putative 0.0026 0.0276 0.5239
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0878 0.0878
Onchocerca volvulus 0.0016 0.0125 0.0245
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0026 0.0276 0.5846
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0201 0.2892 0.2892
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0308 0.4488 1
Echinococcus granulosus cathepsin L cysteine protease 0.0008 0.0006 0.0006
Echinococcus multilocularis geminin 0.0336 0.4919 0.4919
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.016 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.016 0.035
Loa Loa (eye worm) hypothetical protein 0.0049 0.0619 0.0849
Echinococcus multilocularis FTZ F1 alpha 0.0105 0.1447 0.1447
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0522 0.1156
Trypanosoma brucei heat shock protein, putative 0.0026 0.0276 0.0386
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.016 0.016
Mycobacterium ulcerans putative regultory protein 0.0026 0.0276 0.1281
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0276 0.0608
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0815 0.1155
Onchocerca volvulus 0.0047 0.0587 0.1636
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0105 0.1447 0.2033
Brugia malayi ecdysone receptor 0.0049 0.0619 0.0875
Trypanosoma brucei heat shock protein, putative 0.0026 0.0276 0.0386
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0092 0.0092
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0143 0.0399
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0122 0.0166
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0105 0.1447 0.1447
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0447 0.0447
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0105 0.1447 0.2033
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0053 0.0676 0.0956
Echinococcus multilocularis microtubule associated protein 2 0.0676 1 1
Echinococcus multilocularis glycine receptor subunit beta 0.0059 0.076 0.076
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0105 0.1447 0.1447
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0105 0.1447 0.1447
Brugia malayi Cathepsin L-like precursor 0.0016 0.0125 0.017
Chlamydia trachomatis DNA gyrase subunit B 0.0026 0.0276 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0105 0.1447 0.1447
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0522 0.1759
Loa Loa (eye worm) hypothetical protein 0.0084 0.1132 0.1584
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0125 0.027
Mycobacterium tuberculosis Conserved hypothetical protein 0.0014 0.0092 0.0251
Loa Loa (eye worm) hypothetical protein 0.0038 0.0447 0.0603
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.2064 0.2064
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0026 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0052
Schistosoma mansoni RAR-like nuclear receptor 0.0105 0.1447 0.1447
Brugia malayi nuclear receptor RXR 0.0055 0.0707 0.1001
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0643 0.0797
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0482 0.0679
Loa Loa (eye worm) hypothetical protein 0.0038 0.0447 0.0603
Schistosoma mansoni cpg binding protein 0.003 0.0324 0.0324
Leishmania major heat shock protein 83-1 0.0026 0.0276 0.0267
Brugia malayi PXA domain containing protein 0.0019 0.016 0.0221
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0049 0.0619 0.0849
Schistosoma mansoni nuclear receptor 0.0049 0.0619 0.0619
Trichomonas vaginalis spcc417.12 protein, putative 0.0012 0.0052 0.0108
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0447 0.0989
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0038
Loa Loa (eye worm) hypothetical protein 0.0019 0.0159 0.019
Loa Loa (eye worm) hypothetical protein 0.0055 0.0709 0.0979
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0643 0.0797
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0253 0.0233
Giardia lamblia Pms1-like protein 0.0026 0.0276 0.0204
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0059 0.076 0.076
Trypanosoma brucei heat shock protein, putative 0.0026 0.0276 0.0386
Loa Loa (eye worm) hypothetical protein 0.0049 0.0619 0.0849
Echinococcus granulosus axis inhibition protein axin 0.0019 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0105 0.1447 0.2033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.4488 1
Leishmania major heat shock protein 83-1 0.0026 0.0276 0.0267
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0026 0.0276 0.0778
Schistosoma mansoni DNA topoisomerase II 0.0026 0.0276 0.0276
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.076 0.076
Loa Loa (eye worm) hypothetical protein 0.0049 0.0619 0.0849
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0815 0.1155
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0109 0.1516 0.1516
Plasmodium vivax vivapain-2 0.0016 0.0125 0.2308
Entamoeba histolytica cysteine protease, putative 0.0016 0.0125 0.0266
Onchocerca volvulus 0.0049 0.0619 0.1732
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0105 0.1447 0.2056
Loa Loa (eye worm) hypothetical protein 0.0105 0.1447 0.2033
Echinococcus multilocularis glycine receptor subunit beta 0.0059 0.076 0.076
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0105 0.1447 0.1447
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0125 0.027
Brugia malayi nuclear hormone receptor 0.0105 0.1447 0.2056
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0125 0.0245
Mycobacterium tuberculosis Possible two component sensor kinase 0.0026 0.0276 0.0778
Echinococcus multilocularis expressed protein 0.0008 0.0004 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0482 0.0679
Brugia malayi Cathepsin L-like precursor 0.0016 0.0125 0.017
Leishmania major cathepsin L-like protease 0.0016 0.0125 0.0048
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0012 0.0062 0.0062
Mycobacterium tuberculosis Probable two component sensor kinase 0.0026 0.0276 0.0778
Loa Loa (eye worm) hypothetical protein 0.0026 0.0276 0.0358
Echinococcus multilocularis BC026374 protein (S09 family) 0.0012 0.0052 0.0052
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0615 0.0869
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0044 0.0044
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0006 0.0006
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0105 0.1447 0.1447
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.4488 1
Brugia malayi Carboxylesterase family protein 0.0068 0.0901 0.1278
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.016 0.0221
Schistosoma mansoni zinc finger protein 0.0049 0.0619 0.0619
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0026 0.0276 0.0386
Brugia malayi Cathepsin L-like precursor 0.0011 0.0044 0.0054
Schistosoma mansoni ferritin 0.0008 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0105 0.1447 0.2033
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0049 0.0619 0.0619
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0326 0.0326
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0522 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0038
Leishmania major hypothetical protein, conserved 0.0038 0.0447 0.0513
Brugia malayi Rhodanese-like domain containing protein 0.0055 0.0709 0.1004
Loa Loa (eye worm) hypothetical protein 0.0105 0.1447 0.2033
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0167 0.0167
Schistosoma mansoni heat shock protein 0.0026 0.0276 0.0276
Brugia malayi hypothetical protein 0.0049 0.0619 0.0875
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0125 0.0142
Leishmania major heat shock protein 83-1 0.0026 0.0276 0.0267
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0105 0.1447 0.1447
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0253 0.0353
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0276 0.0204
Brugia malayi Nuclear hormone receptor E75 0.0049 0.0619 0.0875
Trypanosoma brucei DNA polymerase eta, putative 0.0014 0.0092 0.0122
Schistosoma mansoni neuroligin 3 (S09 family) 0.0012 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0051 0.0638 0.0638
Echinococcus granulosus transcription factor Dp 1 0.0037 0.044 0.044
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0482 0.0679
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0253 0.0712
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0447 0.1266
Loa Loa (eye worm) hypothetical protein 0.0019 0.016 0.0193
Onchocerca volvulus 0.0039 0.0464 0.1266
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0335 0.047
Brugia malayi hypothetical protein 0.0019 0.016 0.0221
Echinococcus granulosus nuclear receptor nhr 48 0.0049 0.0619 0.0619
Onchocerca volvulus 0.0012 0.0062 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0105 0.1447 0.2033
Brugia malayi RNA binding protein 0.0067 0.0878 0.1245
Loa Loa (eye worm) hypothetical protein 0.0038 0.0447 0.0603
Schistosoma mansoni ferritin 0.0008 0.0004 0.0004
Brugia malayi polk-prov protein 0.003 0.0335 0.047
Leishmania major heat shock protein 83-1 0.0026 0.0276 0.0267
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0125 0.0125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0105 0.1447 0.2033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0159 0.019
Brugia malayi heat shock protein 90 0.0026 0.0276 0.0386
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0587 0.0829
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0105 0.1447 0.2056
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0482 0.0679
Onchocerca volvulus 0.0012 0.0062 0.0056
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0253 0.0552
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0253 0.1173
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0482 0.0679
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0055 0.0709 0.1574
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0253 0.0233
Schistosoma mansoni hypothetical protein 0.0336 0.4919 0.4919
Brugia malayi hypothetical protein 0.0055 0.0707 0.1001
Schistosoma mansoni nuclear receptor 0.0049 0.0619 0.0619
Leishmania major heat shock protein 83-1 0.0026 0.0276 0.0267
Brugia malayi Nuclear hormone receptor E75 0.0049 0.0619 0.0875
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0092 0.0122
Echinococcus granulosus Nuclear hormone receptor HR96 0.0049 0.0619 0.0619
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0049 0.0619 0.0849
Loa Loa (eye worm) hypothetical protein 0.0038 0.0447 0.0603
Schistosoma mansoni DNA polymerase eta 0.0014 0.0092 0.0092
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0026 0.0276 0.0386
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0125 0.027
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0447 0.0447
Echinococcus granulosus thyroid hormone receptor alpha 0.0049 0.0619 0.0619
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0055 0.0709 0.0709
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0643 0.0883
Toxoplasma gondii cathepsin CPL 0.0016 0.0125 0.0304
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0026 0.0276 0.1281
Brugia malayi excitatory GABA receptor EXP-1A 0.0012 0.0062 0.008
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0026 0.0276 0.0778
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0012 0.0062 0.0062
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0105 0.1447 0.4227
Entamoeba histolytica rodhanase-like domain containing protein 0.0055 0.0709 0.157
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0232 0.438
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0166 0.2373 0.8545
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0049 0.0619 0.0619
Brugia malayi Cation transporter family protein 0.0012 0.0062 0.008
Leishmania major heat shock protein 83-1 0.0026 0.0276 0.0267
Loa Loa (eye worm) hypothetical protein 0.003 0.0326 0.043
Onchocerca volvulus 0.0055 0.0709 0.2006
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0109 0.1516 0.1516
Schistosoma mansoni heat shock protein 0.0026 0.0276 0.0276
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0253 0.0552
Schistosoma mansoni hypothetical protein 0.0047 0.0587 0.0587
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.4488 1
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0044 0.0085
Echinococcus multilocularis ferritin 0.0008 0.0004 0.0004
Loa Loa (eye worm) GABA receptor subunit 0.0053 0.0676 0.093
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0026 0.0276 0.1281
Schistosoma mansoni hypothetical protein 0.0039 0.0464 0.0464
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0146 0.2064 0.2064
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.016 0.035
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0464 0.0464
Trichomonas vaginalis cdc25b, putative 0.0055 0.0709 0.1574
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0253 0.1173
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0026 0.0276 0.07
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0643 0.0909
Loa Loa (eye worm) DR-78 0.0049 0.0619 0.0849
Trypanosoma cruzi Heat shock protein 83, putative 0.0026 0.0276 0.0386
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0012 0.0062 0.0052
Leishmania major cathepsin L-like protease 0.0016 0.0125 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0122 0.0166
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.016 0.016
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0026 0.0276 0.0386
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0447 0.2085
Mycobacterium leprae Probable two component sensor kinase MprB 0.0026 0.0276 0.1281
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0482 0.0679
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0276 0.0608
Brugia malayi hypothetical protein 0.0012 0.0052 0.0066
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0447 0.1266
Echinococcus granulosus expressed protein 0.0365 0.5354 0.5354
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0026 0.0276 0.0778
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0125 0.027
Onchocerca volvulus 0.0016 0.0125 0.0245
Loa Loa (eye worm) carboxylesterase 0.0012 0.0052 0.0038
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0125 0.0048
Mycobacterium tuberculosis Conserved protein 0.0038 0.0447 0.1266
Echinococcus granulosus cysteine protease 0.0008 0.0006 0.0006
Onchocerca volvulus 0.0105 0.1447 0.4227
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0105 0.1447 0.2056
Trypanosoma brucei unspecified product 0.001 0.0026 0.0028
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0847 0.0847
Brugia malayi Cathepsin L-like precursor 0.0016 0.0125 0.017
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0125 0.017
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0068 0.0901 0.0901
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.1132 0.1608
Onchocerca volvulus 0.0012 0.0052 0.0025
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.016 0.016
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0878 0.0878
Trypanosoma brucei heat shock protein, putative 0.0026 0.0276 0.0386
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.076 0.076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.4488 1
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0026 0.0276 0.1281
Trypanosoma brucei heat shock protein, putative 0.0026 0.0276 0.0386
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0055 0.0707 0.0707
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0105 0.1447 0.2056
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0167 0.0167
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0026 0.0276 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.016 0.016
Onchocerca volvulus 0.0039 0.0464 0.1266
Trichomonas vaginalis set domain proteins, putative 0.0233 0.3362 0.7491
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0125 0.0266
Trypanosoma brucei DNA topoisomerase ii 0.0026 0.0276 0.0386
Trypanosoma cruzi DNA topoisomerase II, putative 0.0026 0.0276 0.0386
Mycobacterium leprae Probable lipase LipE 0.0038 0.0447 0.2085
Schistosoma mansoni nAChR subunit 0.0012 0.0062 0.0062
Onchocerca volvulus 0.0025 0.0253 0.0631
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0038
Echinococcus granulosus glycine receptor subunit alpha 1 0.0059 0.076 0.076
Trichomonas vaginalis DNA topoisomerase II, putative 0.0026 0.0276 0.0608
Onchocerca volvulus 0.0016 0.0125 0.0245
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0092 0.0122
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0059 0.076 0.076
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0232 0.6225
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0326 0.0326
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0447 0.2085
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0482 0.2247
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0447 0.063
Echinococcus multilocularis para nitrobenzyl esterase 0.0012 0.0052 0.0052
Leishmania major heat shock protein 83-1 0.0026 0.0276 0.0267
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0643 0.1426
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0643 0.0643
Leishmania major cathepsin L-like protease 0.0016 0.0125 0.0048
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0105 0.1447 0.2033
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0878 0.0878
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0815 0.1155
Mycobacterium tuberculosis Conserved protein 0.0026 0.0276 0.0778
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0052
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0276 0.0386
Loa Loa (eye worm) ctsf protein 0.0016 0.0125 0.0142
Loa Loa (eye worm) hypothetical protein 0.0049 0.0619 0.0849
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0026 0.0276 0.0778
Echinococcus multilocularis neuroligin 0.0012 0.0052 0.0052
Brugia malayi MAP kinase sur-1 0.0051 0.0643 0.0909
Schistosoma mansoni hypothetical protein 0.0336 0.4919 0.4919
Echinococcus multilocularis nuclear receptor nhr 48 0.0049 0.0619 0.0619
Echinococcus granulosus acetylcholinesterase 0.0068 0.0901 0.0901
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0105 0.1447 0.1447
Schistosoma mansoni coup transcription factor 0.0105 0.1447 0.1447
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0026 0.0276 0.0608

Activities

Activity type Activity value Assay description Source Reference
Change (functional) = 4 % Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 1 uM ChEMBL. 12593659
Change (functional) = 4 % Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 1 uM ChEMBL. 12593659
Change (functional) = 6 % Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 10 uM ChEMBL. 12593659
Change (functional) = 6 % Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 10 uM ChEMBL. 12593659
Change (functional) = 16 % Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 0.1 uM ChEMBL. 12593659
Change (functional) = 16 % Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 0.1 uM ChEMBL. 12593659
Change (functional) = 18 % Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 0.01 uM ChEMBL. 12593659
Change (functional) = 18 % Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 0.01 uM ChEMBL. 12593659

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.