Detailed information for compound 291095

Basic information

Technical information
  • TDR Targets ID: 291095
  • Name: 4-(4-phenyl-2,6-dipropylpyridin-1-ium-1-yl)be nzenesulfonamide perchlorate
  • MW: 494.988 | Formula: C23H27ClN2O6S
  • H donors: 1 H acceptors: 6 LogP: 7.38 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][Cl](=O)(=O)=O.CCCc1cc(cc([n+]1c1ccc(cc1)S(=O)(=O)N)CCC)c1ccccc1
  • InChi: 1S/C23H27N2O2S.ClHO4/c1-3-8-21-16-19(18-10-6-5-7-11-18)17-22(9-4-2)25(21)20-12-14-23(15-13-20)28(24,26)27;2-1(3,4)5/h5-7,10-17H,3-4,8-9H2,1-2H3,(H2,24,26,27);(H,2,3,4,5)/q+1;/p-1
  • InChiKey: LJCMDNIZHPWQBZ-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • 4-(4-phenyl-2,6-dipropyl-pyridin-1-ium-1-yl)benzenesulfonamide perchlorate
  • 4-(4-phenyl-2,6-dipropyl-1-pyridin-1-iumyl)benzenesulfonamide perchlorate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Carbonic anhydrase IV Starlite/ChEMBL References
Homo sapiens carbonic anhydrase II Starlite/ChEMBL References
Homo sapiens carbonic anhydrase I Starlite/ChEMBL References
Homo sapiens carbonic anhydrase IX Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus granulosus carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) carbonic anhydrase 3 Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus multilocularis carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania braziliensis carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania infantum carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei gambiense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Putative carbonic anhydrase 5 precursor Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania donovani carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania mexicana carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Eukaryotic-type carbonic anhydrase family protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni carbonic anhydrase-related Carbonic anhydrase IV   312 aa 264 aa 24.2 %
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Carbonic anhydrase IV   312 aa 322 aa 28.3 %
Leishmania braziliensis carbonic anhydrase-like protein Carbonic anhydrase IV   312 aa 277 aa 25.6 %
Trypanosoma cruzi carbonic anhydrase-like protein, putative Carbonic anhydrase IV   312 aa 264 aa 25.4 %
Onchocerca volvulus Carbonic anhydrase IV   312 aa 252 aa 23.4 %
Leishmania infantum carbonic anhydrase-like protein Carbonic anhydrase IV   312 aa 277 aa 26.7 %
Trypanosoma brucei carbonic anhydrase-like protein carbonic anhydrase I 261 aa 281 aa 25.3 %
Brugia malayi Carbonic anhydrase like protein 2 precursor Carbonic anhydrase IV   312 aa 268 aa 24.6 %
Echinococcus granulosus carbonic anhydrase Carbonic anhydrase IV   312 aa 304 aa 29.6 %
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Carbonic anhydrase IV   312 aa 253 aa 26.9 %
Loa Loa (eye worm) hypothetical protein Carbonic anhydrase IV   312 aa 268 aa 25.4 %
Brugia malayi Carbonic anhydrase like protein 2 precursor carbonic anhydrase II 260 aa 259 aa 32.0 %
Echinococcus multilocularis carbonic anhydrase Carbonic anhydrase IV   312 aa 259 aa 30.1 %
Schistosoma mansoni carbonic anhydrase-related Carbonic anhydrase IV   312 aa 265 aa 26.0 %
Leishmania mexicana carbonic anhydrase-like protein Carbonic anhydrase IV   312 aa 287 aa 26.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.0172 0.0869
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0024 0.027
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0024 0.027
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0644 0.0911 0.4608
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0634 0.0896 0.2583
Onchocerca volvulus Casein kinase II subunit beta homolog 0.004 0.0035 0.032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0624 0.0882 0.672
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0349 0.0483 1
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0035 0.0028 0.021
Loa Loa (eye worm) phosphatidylinositol 3 0.0591 0.0834 0.4745
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0008 0.0247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0384 0.0534 0.4044
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0148 0.0422
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0035 0.0211
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0066 0.0073 0.0506
Leishmania major protein kinase ck2 regulatory subunit, putative 0.004 0.0035 0.0089
Trypanosoma brucei Casein kinase II 0.0149 0.0193 0.205
Echinococcus granulosus carbonic anhydrase 0.0134 0.0172 0.0172
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0134 0.0172 0.1966
Echinococcus multilocularis expressed conserved protein 0.0089 0.0106 0.0106
Echinococcus granulosus single minded 2 0.0039 0.0034 0.0034
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0055 0.0279
Schistosoma mansoni hypothetical protein 0.0186 0.0247 0.1247
Schistosoma mansoni kinase 0.0107 0.0133 0.0672
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0148 0.0751
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0045 0.0043 0.0271
Entamoeba histolytica hypothetical protein 0.0039 0.0034 0.0203
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0919 0.1309 0.3776
Loa Loa (eye worm) gastrulation defective protein 1 0.0142 0.0183 0.1039
Brugia malayi PAS domain containing protein 0.0053 0.0054 0.041
Loa Loa (eye worm) hypothetical protein 0.0054 0.0055 0.0313
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0008 0.0055
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0008 0.0007
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0644 0.0911 0.2626
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0073 0.0506
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0034 0.0171
Echinococcus multilocularis lamin 0.003 0.002 0.002
Echinococcus granulosus carbonic anhydrase 0.0134 0.0172 0.0172
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0134 0.0172 0.0172
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.023 0.0311 0.336
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0008 0.0037
Echinococcus multilocularis geminin 0.0186 0.0247 0.0246
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0148 0.1084
Brugia malayi Cytochrome P450 family protein 0.0021 0.0008 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0279 0.2088
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0066 0.0073 0.0506
Toxoplasma gondii hypothetical protein 0.0134 0.0172 0.1965
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0024 0.0541
Giardia lamblia Kinase, CMGC GSK 0.0055 0.0058 0.0383
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0194 0.0259 0.1976
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0134 0.0172 0.1312
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0008 0.0037
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0035 0.0211
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0008 0.0015
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0073 0.0506
Entamoeba histolytica hypothetical protein 0.0039 0.0034 0.0203
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.0172 0.0869
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0066 0.0073 0.0726
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0024 0.0541
Loa Loa (eye worm) hypothetical protein 0.0111 0.0138 0.0786
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0148 0.1084
Onchocerca volvulus 0.0045 0.0043 0.049
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0919 0.1309 1
Loa Loa (eye worm) hypothetical protein 0.024 0.0325 0.1852
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0134 0.0172 0.552
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0134 0.0172 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0624 0.0882 0.672
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0035 0.0211
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0349 0.0483 0.2444
Giardia lamblia Kinase, CMGC GSK 0.0055 0.0058 0.0383
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0919 0.1309 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0619 0.0875 0.6664
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0013 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0339 0.0469 0.3544
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0382 0.0531 0.4022
Mycobacterium ulcerans putative regulatory protein 0.0021 0.0008 0.0007
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0066 0.0073 0.0506
Schistosoma mansoni casein kinase II beta subunit 0.004 0.0035 0.0176
Echinococcus multilocularis high voltage activated calcium channel beta 0.0094 0.0114 0.0114
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0148 0.1084
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0035 0.0211
Loa Loa (eye worm) hypothetical protein 0.0177 0.0234 0.1333
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.0172 0.1311
Echinococcus granulosus tumor protein p63 0.0367 0.0509 0.0509
Trichomonas vaginalis PIKK family atypical protein kinase 0.0599 0.0846 0.6442
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0382 0.0531 0.4022
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0193 0.1425
Schistosoma mansoni hypothetical protein 0.0039 0.0034 0.0171
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0011 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0591 0.0834 0.635
Loa Loa (eye worm) hypothetical protein 0.0134 0.0172 0.0977
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0134 0.0172 0.0869
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.0172 0.0869
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0073 0.0506
Onchocerca volvulus 0.0105 0.013 0.237
Loa Loa (eye worm) phosphatidylinositol 3 0.0134 0.0172 0.0978
Entamoeba histolytica hypothetical protein 0.0039 0.0034 0.0203
Entamoeba histolytica hypothetical protein 0.0767 0.1089 0.8312
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0008 0.0007
Trichomonas vaginalis set domain proteins, putative 0.026 0.0354 0.2661
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0118 0.0148 0.8572
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.015 0.0195 0.0556
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0073 0.0506
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0339 0.0469 0.1347
Plasmodium falciparum casein kinase II beta chain 0.004 0.0035 0.0917
Echinococcus granulosus voltage dependent calcium channel 0.0035 0.0028 0.0028
Brugia malayi SH2 domain containing protein 0.0369 0.0513 0.3916
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0134 0.0172 0.1311
Mycobacterium ulcerans putative regulatory protein 0.0021 0.0008 0.0007
Schistosoma mansoni hypothetical protein 0.024 0.0325 0.1646
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0034 0.1861
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0248 0.0336 0.2569
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0644 0.0911 0.2626
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0382 0.0531 0.4055
Giardia lamblia GTOR 0.0644 0.0911 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0004 0.002
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0591 0.0834 0.2275
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0208 0.0279 0.0279
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0099 0.012 0.0607
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0248 0.0336 0.1702
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0666 0.0943 0.7204
Leishmania major casein kinase II, putative 0.0149 0.0193 0.0521
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0062 0.0416
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.023 0.0311 0.1771
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0052 0.0052 0.0298
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0148 0.1084
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0881 0.1254 0.1254
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0279 0.2088
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0134 0.0172 0.0172
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0193 0.1425
Echinococcus multilocularis survival motor neuron protein 1 0.0516 0.0725 0.0725
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0382 0.0531 0.1527
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0193 0.1425
Echinococcus multilocularis tumor protein p63 0.0367 0.0509 0.0509
Echinococcus multilocularis voltage dependent calcium channel 0.0035 0.0028 0.0028
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0349 0.0483 0.275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0154 0.0201 0.1485
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.023 0.0311 0.2334
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0644 0.0911 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0024 0.0123
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0024 0.075
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0148 0.1084
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0099 0.012 0.0607
Loa Loa (eye worm) phosphatidylinositol 3 0.0644 0.0911 0.5184
Echinococcus granulosus high voltage activated calcium channel beta 0.0094 0.0114 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0404 0.0563 0.4267
Echinococcus granulosus nuclear factor of activated T cells 5 0.008 0.0093 0.0093
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0134 0.0172 0.1264
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0035 0.0028 0.0028
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0035 0.0211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0599 0.0846 0.6442
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0008 0.0037
Entamoeba histolytica hypothetical protein 0.0134 0.0172 0.1264
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0193 0.1425
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0035 0.0211
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0149 0.0193 0.1098
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0248 0.0336 0.2569
Trichomonas vaginalis conserved hypothetical protein 0.0205 0.0274 0.2048
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0355 0.0492 0.1414
Schistosoma mansoni protein kinase 0.0149 0.0193 0.0976
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0073 0.0506
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0025 0.0283
Toxoplasma gondii target of rapamycin (TOR), putative 0.0619 0.0875 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0624 0.0882 0.2542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0579 0.0817 0.622
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0129 0.0933
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.138 0.1976 0.1976
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0029 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0019 0.011
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0579 0.0817 0.8958
Echinococcus granulosus expressed conserved protein 0.0089 0.0106 0.0106
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0134 0.0172 0.1817
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.023 0.0311 0.2334
Leishmania major phosphatidylinositol 4-kinase, putative 0.0134 0.0172 0.0464
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0035 0.0028 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0644 0.0911 0.6943
Brugia malayi Cytochrome P450 family protein 0.0032 0.0024 0.0182
Loa Loa (eye worm) phosphatidylinositol 3 0.0134 0.0172 0.0978
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.023 0.0311 0.2334
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0035 0.0028 0.014
Echinococcus multilocularis 6 phosphofructokinase 0.0118 0.0148 0.0148
Trypanosoma brucei Casein kinase II subunit beta, putative 0.004 0.0035 0.0301
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0008 0.0037
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0375 0.052 0.5947
Plasmodium falciparum casein kinase 2, alpha subunit 0.0149 0.0193 0.6112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0379 0.0526 0.3988
Plasmodium falciparum glycogen synthase kinase 3 0.0055 0.0058 0.166
Schistosoma mansoni hypothetical protein 0.0105 0.013 0.0657
Brugia malayi Protein kinase domain containing protein 0.0019 0.0005 0.0038
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0919 0.1309 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.023 0.0311 0.3559
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0008 0.0037
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0054 0.0272
Brugia malayi Pre-SET motif family protein 0.0228 0.0308 0.2353
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0105 0.013 0.0991
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0023 0.0023
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0148 0.1084
Loa Loa (eye worm) hypothetical protein 0.0035 0.0028 0.0157
Brugia malayi hypoxia-induced factor 1 0.0164 0.0214 0.1637
Onchocerca volvulus 0.0111 0.0138 0.2551
Onchocerca volvulus 0.0054 0.0055 0.0756
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0208 0.0279 0.1588
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0035 0.0211
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0034 0.0034
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0094 0.0114 0.0114
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0024 0.0123
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0008 0.0037
Brugia malayi 6-phosphofructokinase 0.0118 0.0148 0.1133
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0008 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0431 0.0602 0.4572
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0073 0.0205
Echinococcus multilocularis nuclear factor of activated T cells 5 0.008 0.0093 0.0093
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0058 0.0385
Toxoplasma gondii hypothetical protein 0.0058 0.0062 0.0705
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0025 0.0013 0.0072
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0382 0.0531 0.4022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0644 0.0911 0.6943
Trichomonas vaginalis PIKK family atypical protein kinase 0.0619 0.0875 0.6664
Echinococcus granulosus survival motor neuron protein 1 0.0516 0.0725 0.0725
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0134 0.0172 0.049
Schistosoma mansoni lamin 0.003 0.002 0.0101
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0134 0.0172 0.0977
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0634 0.0896 0.0896
Leishmania major phosphatidylinositol 3-kinase, putative 0.023 0.0311 0.0845
Echinococcus granulosus geminin 0.0186 0.0247 0.0246
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0634 0.0896 0.0896
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0073 0.0506
Trichomonas vaginalis PIKK family atypical protein kinase 0.0599 0.0846 0.6442
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0008 0.0037
Toxoplasma gondii GAF domain-containing protein 0.0021 0.0008 0.0091
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0193 0.1425
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0129 0.0933
Schistosoma mansoni lamin 0.003 0.002 0.0101
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0248 0.0336 0.1702
Echinococcus multilocularis casein kinase ii subunit beta 0.004 0.0035 0.0035
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0008 0.0007
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0193 0.1425
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0011 0.0029
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0148 0.0844
Leishmania major cytochrome p450-like protein 0.0021 0.0008 0.0014
Schistosoma mansoni single-minded 0.0053 0.0054 0.0272
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0134 0.0172 0.5419
Toxoplasma gondii ck2 beta subunit 0.004 0.0035 0.04
Schistosoma mansoni hypothetical protein 0.0134 0.0172 0.0869
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0011 0.0084
Leishmania major phosphatidylinositol kinase related protein, putative 0.015 0.0195 0.0527
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0257 0.035 0.1989
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0073 0.0506
Giardia lamblia Kinase, PLK 0.0208 0.0279 0.2881
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0042
Plasmodium vivax casein kinase II beta chain, putative 0.004 0.0035 0.1118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0134 0.0172 0.1264
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.001 0.0055
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0134 0.0172 0.1966
Schistosoma mansoni serine/threonine protein kinase 0.0208 0.0279 0.1412
Trypanosoma brucei carbonic anhydrase-like protein 0.0248 0.0336 0.3639
Entamoeba histolytica casein kinase, putative 0.0149 0.0193 0.1425
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0024 0.5
Plasmodium falciparum GAF domain-related protein, putative 0.0021 0.0008 0.0027
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0058 0.0385
Loa Loa (eye worm) phosphatidylinositol 3 0.1228 0.1757 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0351 0.0486 0.3674
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0055 0.0058 0.0151
Plasmodium falciparum casein kinase II beta chain 0.004 0.0035 0.0917
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0073 0.0506
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0008 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0145 0.0188 0.0951
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0066 0.0073 0.0506
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0034
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0008 0.0007
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0035 0.0211
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0044
Onchocerca volvulus 0.0111 0.0138 0.2551
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0045 0.0043 0.0271
Toxoplasma gondii FATC domain-containing protein 0.0355 0.0492 0.5622
Echinococcus multilocularis cyclin dependent kinase 19 0.0145 0.0188 0.0188
Schistosoma mansoni fkbp-rapamycin associated protein 0.0339 0.0469 0.2371
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0066 0.0073 0.0371
Onchocerca volvulus 0.0039 0.0034 0.0299
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0664 0.0939 0.0939
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0055 0.0058 0.0291
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.138 0.1976 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.023 0.0311 0.0892
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0025 0.0025
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0349 0.0483 0.275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0619 0.0875 0.6664
Plasmodium vivax SET domain protein, putative 0.0033 0.0025 0.0788
Plasmodium vivax hypothetical protein 0.0134 0.0172 0.552
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.023 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.0664 0.0939 0.5346
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.023 0.0311 0.2334
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0024 0.027
Loa Loa (eye worm) hypothetical protein 0.0369 0.0513 0.2918
Brugia malayi intermediate filament protein 0.003 0.002 0.0152
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0029 0.002 0.002
Echinococcus granulosus protein kinase shaggy 0.0055 0.0058 0.0057
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0035 0.0028 0.0028
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0134 0.0172 0.1312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0205 0.0274 0.2048
Mycobacterium ulcerans 6-phosphofructokinase 0.0118 0.0148 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0134 0.0172 0.0172
Plasmodium vivax glycogen synthase kinase 3, putative 0.0055 0.0058 0.1844
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.6918 1 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0208 0.0279 0.08
Loa Loa (eye worm) hypothetical protein 0.0134 0.0172 0.0977
Brugia malayi Casein kinase II, alpha chain 0.0149 0.0193 0.1473
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0035 0.0028 0.0028
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0355 0.0492 0.2487
Toxoplasma gondii hypothetical protein 0.0021 0.0008 0.0091
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0134 0.0172 0.1966
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0099 0.012 0.012
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0008 0.0037
Brugia malayi Csnk2b protein 0.004 0.0035 0.0265
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0011 0.0011
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0785 0.1114 0.8504
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0025 0.0025
Brugia malayi M-phase phosphoprotein, mpp8 0.0111 0.0138 0.1055
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0062 0.0416
Brugia malayi hypothetical protein 0.0021 0.0008 0.0055
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0644 0.0911 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0008 0.0007
Echinococcus granulosus carbonic anhydrase II 0.0248 0.0336 0.0336
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0073 0.0506
Echinococcus granulosus carbonic anhydrase 0.0134 0.0172 0.0172
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0025 0.0125
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0013 0.0064
Echinococcus multilocularis casein kinase ii subunit alpha 0.0149 0.0193 0.0193
Echinococcus multilocularis carbonic anhydrase 0.0134 0.0172 0.0172
Trichomonas vaginalis conserved hypothetical protein 0.024 0.0325 0.2444
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.004 0.0035 0.0094
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0099 0.012 0.012
Echinococcus multilocularis carbonic anhydrase 0.0134 0.0172 0.0172
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0339 0.0469 0.0468
Plasmodium falciparum phosphatidylinositol 3-kinase 0.023 0.0311 1
Brugia malayi hypothetical protein 0.0039 0.0034 0.0258
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0919 0.1309 0.3776
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.002 0.0152
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0463 0.0648 0.4923
Mycobacterium leprae conserved hypothetical protein 0.0134 0.0172 1
Brugia malayi intracellular kinase 0.0055 0.0058 0.0438
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.023 0.0311 0.1574
Echinococcus granulosus casein kinase ii subunit beta 0.004 0.0035 0.0035
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0148 0.0751
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0686 0.0972 0.7412
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0025 0.0013 0.0072
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0024 0.0123
Brugia malayi hypothetical protein 0.0177 0.0234 0.1789
Loa Loa (eye worm) Csnk2b protein 0.004 0.0035 0.0198
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0919 0.1309 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0008 0.0003
Leishmania major hypothetical protein, unknown function 0.0134 0.0172 0.0464
Loa Loa (eye worm) intermediate filament protein 0.003 0.002 0.0114
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0134 0.0172 0.1312
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.023 0.0311 0.2334
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0148 0.1558
Echinococcus granulosus serine protein kinase ATM 0.0355 0.0492 0.0491
Echinococcus multilocularis serine protein kinase ATM 0.0355 0.0492 0.0491
Echinococcus multilocularis carbonic anhydrase II 0.0248 0.0336 0.0336
Leishmania major ATP-dependent phosphofructokinase 0.0118 0.0148 0.0399
Trypanosoma cruzi polo-like protein kinase, putative 0.0208 0.0279 0.08
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0073 0.0205
Brugia malayi hypothetical protein 0.0516 0.0725 0.5543
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0055 0.0058 0.0327
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0073 0.0506
Echinococcus multilocularis lamin dm0 0.003 0.002 0.002
Loa Loa (eye worm) phosphofructokinase 0.0118 0.0148 0.0844
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0767 0.1089 0.8312
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0174 0.023 0.2457
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0062 0.0416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0379 0.0526 0.3988
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0045 0.0043 0.0116
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0279 0.2088
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0073 0.0506
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0134 0.0172 0.0869
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0024 0.0123
Brugia malayi PXA domain containing protein 0.0022 0.001 0.0072
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0008 0.0037
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0134 0.0172 0.552
Loa Loa (eye worm) phosphatidylinositol 3 0.0248 0.0336 0.1913
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0035 0.0211
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.0308 0.1753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0579 0.0817 0.622
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0279 0.2088
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0029 0.002 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0604 0.0853 0.6499
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.023 0.0311 0.0311
Entamoeba histolytica protein kinase, putative 0.0055 0.0058 0.0385
Plasmodium vivax hypothetical protein, conserved 0.0134 0.0172 0.552
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0382 0.0531 0.5792
Loa Loa (eye worm) hypothetical protein 0.003 0.002 0.0114
Brugia malayi follicle stimulating hormone receptor 0.0257 0.035 0.2669
Trichomonas vaginalis PIKK family atypical protein kinase 0.0619 0.0875 0.6664
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0034 0.0034
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0008 0.0007
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.023 0.0311 0.0845
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0134 0.0172 0.552
Leishmania major hypothetical protein, conserved 0.2539 0.3656 1
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0008 0.0042
Onchocerca volvulus 0.0134 0.0172 0.3277
Leishmania major carbonic anhydrase-like protein 0.0248 0.0336 0.0914
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0073 0.0506
Echinococcus granulosus intermediate filament protein 0.003 0.002 0.002
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0193 0.1425
Loa Loa (eye worm) phosphatidylinositol 3 0.0134 0.0172 0.0978
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0134 0.0172 0.1264
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0066 0.0073 0.0506
Trypanosoma cruzi casein kinase II, putative 0.0149 0.0193 0.055
Schistosoma mansoni hypothetical protein 0.0057 0.006 0.03
Echinococcus multilocularis Zinc finger, PHD finger 0.023 0.0311 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0134 0.0172 0.1264
Loa Loa (eye worm) hypothetical protein 0.0134 0.0172 0.0977
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0035 0.0211
Loa Loa (eye worm) phosphatidylinositol kinase 0.0134 0.0172 0.0978
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0134 0.0172 0.0172
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0025 0.0125
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0094 0.0114 0.0576
Loa Loa (eye worm) hypothetical protein 0.0134 0.0172 0.0978
Trichomonas vaginalis PIKK family atypical protein kinase 0.0599 0.0846 0.6441
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0073 0.0506
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0 0.0001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0644 0.0911 0.696
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.0112
Schistosoma mansoni hypothetical protein 0.0134 0.0172 0.0869
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0279 0.2088
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0395 0.0549 0.5993
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0008 0.0007
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0055 0.0058 0.0159
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0035 0.0211
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.0073 0.0506
Brugia malayi Cytochrome P450 family protein 0.0021 0.0008 0.0058
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0073 0.0506
Brugia malayi hypothetical protein 0.0111 0.0138 0.1056
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0349 0.0483 0.0483
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0008 0.0007
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0073 0.0506
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0066 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0042
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0008 0.0044
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0248 0.0336 0.0965
Schistosoma mansoni phosphatidylinositol 4-kinase 0.023 0.0311 0.1574
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0008 0.0055
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.138 0.1976 0.1976
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0339 0.0469 0.0468
Trichomonas vaginalis PIKK family atypical protein kinase 0.0619 0.0875 0.6664
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.0073 0.0506
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0024 0.0123
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0021 0.0008 0.0007
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0055 0.0058 0.0057
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0008 0.0007
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0008 0.0007
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0073 0.0506
Schistosoma mansoni carbonic anhydrase 0.0134 0.0172 0.0869
Brugia malayi phosphofructokinase 0.0118 0.0148 0.1133
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0461 0.0645 0.4928
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0008 0.0015
Brugia malayi 6-phosphofructokinase 0.0118 0.0148 0.1133
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0379 0.0526 0.3988
Trichomonas vaginalis PIKK family atypical protein kinase 0.0351 0.0486 0.3674
Plasmodium vivax unspecified product 0.0149 0.0193 0.6198
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0208 0.0279 0.0757
Giardia lamblia Phosphatidylinositol 4-kinase 0.0134 0.0172 0.1672
Echinococcus multilocularis protein kinase shaggy 0.0055 0.0058 0.0057
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0008 0.0037
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0035 0.0211
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0644 0.0911 0.0911
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0634 0.0896 0.2583
Onchocerca volvulus Serine\/threonine kinase homolog 0.0208 0.0279 0.5594
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0634 0.0896 0.4533
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0382 0.0531 0.4022
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0035 0.0028 0.0028
Loa Loa (eye worm) phosphatidylinositol 3 0.0134 0.0172 0.0978
Loa Loa (eye worm) hypothetical protein 0.0375 0.052 0.296
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0008 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.042 0.0585 0.444
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0066 0.0073 0.0726
Loa Loa (eye worm) carbonic anhydrase 3 0.0248 0.0336 0.1915
Toxoplasma gondii hypothetical protein 0.0021 0.0008 0.0091
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0134 0.0172 0.1264
Loa Loa (eye worm) hypothetical protein 0.0111 0.0138 0.0787
Echinococcus granulosus lamin dm0 0.003 0.002 0.002
Leishmania major phosphatidylinositol 3-kinase, putative 0.0579 0.0817 0.2228
Brugia malayi Protein kinase domain containing protein 0.0145 0.0188 0.1435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0624 0.0882 0.672
Echinococcus multilocularis musashi 0.003 0.002 0.002
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0008 0.0007
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.023 0.0311 1
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.004 0.0035 0.0094
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0029 0.002 0.0094
Echinococcus multilocularis carbonic anhydrase 0.0134 0.0172 0.0172
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0035 0.0211
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0008 0.0037
Entamoeba histolytica protein kinase domain containing protein 0.0149 0.0193 0.1425
Echinococcus granulosus expressed protein 0.0406 0.0565 0.0565
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0042
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0008 0.0055
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.0073 0.0205
Schistosoma mansoni voltage-gated cation channel 0.0035 0.0028 0.014
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.023 0.0311 0.0892
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.014
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0644 0.0911 0.0911
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0208 0.0279 0.0279
Entamoeba histolytica hypothetical protein 0.0134 0.0172 0.1264
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0043 0.0216
Echinococcus granulosus bloom syndrome protein 0.0023 0.0011 0.0011
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0644 0.0911 0.2486
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0248 0.0336 0.0965
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0035 0.0211
Loa Loa (eye worm) hypothetical protein 0.0304 0.0418 0.238
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0248 0.0336 0.0965
Onchocerca volvulus Casein kinase II subunit beta homolog 0.004 0.0035 0.032
Schistosoma mansoni hypothetical protein 0.0089 0.0106 0.0534
Trypanosoma brucei polo-like protein kinase 0.0208 0.0279 0.3005
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0134 0.0172 0.049
Giardia lamblia Casein kinase II beta chain 0.004 0.0035 0.0129
Entamoeba histolytica serine/threonine protein kinase, putative 0.0208 0.0279 0.2088
Mycobacterium tuberculosis Conserved hypothetical protein 0.0134 0.0172 1
Echinococcus granulosus cyclin dependent kinase 19 0.0145 0.0188 0.0188
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0013 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0599 0.0846 0.6441
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0034 0.0258
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0073 0.0506
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0149 0.0193 0.6198
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0073 0.0506
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.023 0.0311 0.0311
Loa Loa (eye worm) calcium channel 0.0035 0.0028 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0375 0.052 0.3939
Trichomonas vaginalis PIKK family atypical protein kinase 0.0599 0.0846 0.6442
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0024 0.5
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.0172 0.1311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0599 0.0846 0.6441
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0134 0.0172 0.1311
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0434 0.0606 0.3066
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0035 0.0028 0.0028
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0919 0.1309 1
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0058 0.0385
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0029 0.002 0.0099
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0042
Trypanosoma brucei protein kinase, putative 0.0055 0.0058 0.0551
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0279 0.2088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0644 0.0911 0.6943
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0644 0.0911 0.6943
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0194 0.0259 0.1472
Schistosoma mansoni hypothetical protein 0.0186 0.0247 0.1247
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0355 0.0492 0.5358
Toxoplasma gondii CMGC kinase, CK2 family 0.0149 0.0193 0.2207
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0029 0.002 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0355 0.0492 0.3721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0579 0.0817 0.622
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0148 0.0844
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0134 0.0172 0.0869
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0008 0.0044
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0339 0.0469 0.358
Brugia malayi Serotonin receptor 0.0507 0.0712 0.5438
Echinococcus multilocularis 0.0134 0.0172 0.0172
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.023 0.0311 0.2377
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0025 0.0013 0.0096
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0664 0.0939 0.0939
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0134 0.0172 0.1817
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0055 0.0058 0.0659
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.023 0.0311 0.3559
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0035 0.0211
Echinococcus multilocularis expressed protein 0.0406 0.0565 0.0565
Schistosoma mansoni survival motor neuron protein 0.0105 0.013 0.0657
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0073 0.0506
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.002 0.0094
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.0172 0.1311
Loa Loa (eye worm) RecQ helicase 0.0023 0.0011 0.0063
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0073 0.0506
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0055 0.0058 0.0057
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0355 0.0492 0.3756
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0008 0.0055
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0145 0.0188 0.1069
Schistosoma mansoni intermediate filament proteins 0.003 0.002 0.0101
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0025 0.0125
Leishmania major phosphatidylinositol kinase, putative 0.0134 0.0172 0.0464
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0042
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.024 0.0325 0.0325
Brugia malayi Pre-SET motif family protein 0.0033 0.0025 0.0187
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0058 0.0385
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0024 0.075
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0024 0.0123
Plasmodium vivax casein kinase II beta chain, putative 0.004 0.0035 0.1118
Brugia malayi hypothetical protein 0.0021 0.0008 0.0055
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0034 0.0034
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0035 0.0211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0619 0.0875 0.6664
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0134 0.0172 0.5419
Entamoeba histolytica hypothetical protein 0.0039 0.0034 0.0203
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0644 0.0911 0.6943
Brugia malayi FAT domain containing protein 0.024 0.0325 0.2486
Giardia lamblia Hypothetical protein 0.0134 0.0172 0.1672
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0029 0.002 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0619 0.0875 0.6664
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.004 0.0035 0.04
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0008 0.0007
Giardia lamblia Kinase, CMGC CK2 0.0149 0.0193 0.1909
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.0073 0.0506
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0094 0.0114 0.0114
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0118 0.0148 1
Trypanosoma cruzi hypothetical protein, conserved 0.2405 0.3461 1
Echinococcus granulosus beta-adrenergic receptor kinase 0.0025 0.0013 0.0013
Brugia malayi PXA domain containing protein 0.0022 0.001 0.0072
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0055 0.0058 0.0327
Entamoeba histolytica hypothetical protein 0.0134 0.0172 0.1264
Echinococcus granulosus casein kinase ii subunit alpha 0.0149 0.0193 0.0193
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0008 0.0007
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0624 0.0882 0.2407
Echinococcus granulosus 6 phosphofructokinase 0.0118 0.0148 0.0148
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0349 0.0483 0.0483
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.024 0.0325 0.0325
Entamoeba histolytica protein kinase rad3, putative 0.0339 0.0469 0.3544
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0591 0.0834 0.9145
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0024 0.0123
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0248 0.0336 0.1915
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0634 0.0896 0.6846
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0134 0.0172 0.0172
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0221 0.0297 0.0851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0579 0.0817 0.622
Loa Loa (eye worm) hypothetical protein 0.0516 0.0725 0.4129
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0535 0.0752 0.8212
Loa Loa (eye worm) hypothetical protein 0.0339 0.0469 0.2667
Loa Loa (eye worm) hypoxia-induced factor 1 0.0164 0.0214 0.122
Onchocerca volvulus 0.0134 0.0172 0.3277
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0024 0.0123
Brugia malayi serine/threonine-protein kinase plk-2 0.0208 0.0279 0.2132
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0024 0.0136
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0134 0.0172 0.049
Loa Loa (eye worm) hypothetical protein 0.0221 0.0297 0.169
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0118 0.0148 0.8572
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0686 0.0972 0.7412
Echinococcus multilocularis voltage dependent calcium channel 0.0035 0.0028 0.0028
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0008 0.0044
Onchocerca volvulus 0.026 0.0354 0.721
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0066 0.0073 0.0506
Plasmodium falciparum carbonic anhydrase 0.0134 0.0172 0.5416
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0349 0.0483 0.3691
Brugia malayi Protein kinase domain containing protein 0.0349 0.0483 0.3691
Onchocerca volvulus 0.0055 0.0058 0.0808
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0008 0.0007
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0066 0.0073 0.0073
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0279 0.2088
Echinococcus multilocularis beta adrenergic receptor kinase 0.0025 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0624 0.0882 0.672
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0148 0.1084
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0035 0.0028 0.0028
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0035 0.0211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0604 0.0853 0.6499
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0008 0.0042
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0644 0.0911 0.2486
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.002 0.0114
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0035 0.0211
Echinococcus granulosus lamin 0.003 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0624 0.0882 0.672
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0008 0.0007
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0035 0.0028 0.014
Entamoeba histolytica hypothetical protein 0.0355 0.0492 0.3721
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0624 0.0882 0.9681
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0286 0.0392 0.4147

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 120 nM Inhibitory activity against human carbonic anhydrase II ChEMBL. 15012984
Ki (binding) = 120 nM Inhibitory activity against human carbonic anhydrase II ChEMBL. 15012984
Ki (binding) = 178 nM Inhibitory activity against human carbonic anhydrase IX ChEMBL. 15012984
Ki (binding) = 178 nM Inhibitory activity against human carbonic anhydrase IX ChEMBL. 15012984
Ki (binding) = 194 nM Inhibitory activity of the compound against carbonic anhydrase IV from bovine lung microsomes ChEMBL. 15012984
Ki (binding) = 194 nM Inhibitory activity of the compound against carbonic anhydrase IV from bovine lung microsomes ChEMBL. 15012984
Ki (binding) = 10 uM Inhibitory activity against human carbonic anhydrase I ChEMBL. 15012984
Ki (binding) = 10 uM Inhibitory activity against human carbonic anhydrase I ChEMBL. 15012984

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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