Detailed information for compound 312692

Basic information

Technical information
  • TDR Targets ID: 312692
  • Name: 3,4-dihydro-2H-chromen-2-ylmethyl sulfamate
  • MW: 243.28 | Formula: C10H13NO4S
  • H donors: 1 H acceptors: 2 LogP: 1.1 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NS(=O)(=O)OCC1CCc2c(O1)cccc2
  • InChi: 1S/C10H13NO4S/c11-16(12,13)14-7-9-6-5-8-3-1-2-4-10(8)15-9/h1-4,9H,5-7H2,(H2,11,12,13)
  • InChiKey: OXNGFJDSVRPPCH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • chroman-2-ylmethyl sulfamate
  • sulfamic acid 3,4-dihydro-2H-1-benzopyran-2-ylmethyl ester
  • sulfamic acid chroman-2-ylmethyl ester
  • sulfamic acid 2-chromanylmethyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens carbonic anhydrase II Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania mexicana carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) carbonic anhydrase 3 Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Putative carbonic anhydrase 5 precursor Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania braziliensis carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei gambiense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus multilocularis carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania donovani carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Eukaryotic-type carbonic anhydrase family protein Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania infantum carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania major carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus granulosus carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Carbonic anhydrase like protein 2 precursor carbonic anhydrase II 260 aa 259 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0108 0.2923
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0179 0.0827 0.0827
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0023 0.0054
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.001 0.0009 0.0068
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0103 0.153
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.001 0.0009 0.045
Echinococcus multilocularis microtubule associated protein 2 0.2075 1 1
Brugia malayi Cytochrome P450 family protein 0.0013 0.0023 0.0054
Trypanosoma brucei unspecified product 0.0019 0.0055 0.0821
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0115 0.0521 0.3852
Echinococcus multilocularis SHC transforming protein 3 0.0008 0.0003 0.0003
Trypanosoma brucei glucose transporter, putative 0.001 0.0009 0.0137
Leishmania major importin beta-1 subunit, putative 0.0027 0.0092 0.1369
Trichomonas vaginalis conserved hypothetical protein 0.007 0.03 0.0609
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0442 0.1022
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0103 0.153
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0206 0.3466
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0103 0.0763
Echinococcus multilocularis tensin 0.0008 0.0003 0.0003
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0034 0.0125 0.0288
Onchocerca volvulus 0.0036 0.0136 0.0275
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0136 0.1003
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.011 0.0496 0.0496
Onchocerca volvulus 0.0008 0.0003 0.0006
Schistosoma mansoni hypothetical protein 0.001 0.0009 0.0009
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0353 0.1673 0.3866
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0055 0.0821
Brugia malayi major facilitator superfamily protein 0.001 0.0009 0.0021
Leishmania major hypothetical protein, conserved 0.0036 0.0136 0.201
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.005 0.0206 0.1521
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0055 0.0821
Loa Loa (eye worm) hypothetical protein 0.0068 0.029 0.0671
Echinococcus granulosus voltage dependent calcium channel 0.0023 0.0074 0.0074
Loa Loa (eye worm) major facilitator superfamily transporter 0.001 0.0009 0.0021
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0461 0.0936
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0218 0.0218
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0019 0.0279
Echinococcus granulosus solute carrier family 22 0.001 0.0009 0.0009
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0287 0.1351 1
Trypanosoma brucei glucose transporter 1E 0.001 0.0009 0.0137
Brugia malayi Mammalian fe65 homolog protein 1 0.0008 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0034 0.0125 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0055 0.0821
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.2806 0.5694
Loa Loa (eye worm) AIDA-1b 0.0008 0.0003 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0218 0.0218
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0136 0.1003
Trypanosoma brucei unspecified product 0.0013 0.0027 0.0393
Toxoplasma gondii transporter, major facilitator family protein 0.001 0.0009 0.0156
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.011 0.0496 0.0496
Trypanosoma cruzi transcription factor btf3, putative 0.007 0.03 0.4448
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0031 0.0062
Brugia malayi glutathione reductase 0.0084 0.0369 0.0852
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.005 0.0206 0.1521
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0108 0.0219
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0066 0.0152
Toxoplasma gondii thioredoxin reductase 0.0084 0.0369 0.6206
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0034 0.0125 0.0288
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0006
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0131 0.0594 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0009 0.0019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0263 0.1945
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.005 0.0206 0.1521
Schistosoma mansoni tensin-related 0.0008 0.0003 0.0003
Mycobacterium tuberculosis Probable reductase 0.0192 0.0889 0.6578
Echinococcus granulosus protein numb 0.0008 0.0003 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0594 0.0594
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0115 0.0521 0.1203
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Echinococcus granulosus amyloid beta A4 protein 0.0079 0.0344 0.0344
Schistosoma mansoni hypothetical protein 0.0023 0.0072 0.0072
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.05 0.05
Schistosoma mansoni sugar transporter 0.001 0.0009 0.0009
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.05 0.1783
Treponema pallidum fructose-bisphosphate aldolase 0.0588 0.2806 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0588 0.2806 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0192 0.0889 0.6578
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.05 0.7418
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0103 0.153
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0103 0.0461 0.7765
Brugia malayi hypothetical protein 0.0032 0.012 0.0276
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.011 0.0496 0.0496
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0019 0.0279
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0206 0.3051
Toxoplasma gondii ABC1 family protein 0.0036 0.0136 0.2283
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0263 0.1945
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0192 0.0889 0.6578
Echinococcus granulosus SHC transforming protein 3 0.0008 0.0003 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0055 0.0821
Trypanosoma cruzi transcription factor btf3, putative 0.007 0.03 0.4448
Loa Loa (eye worm) hypothetical protein 0.0036 0.0136 0.0313
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0009 0.0137
Echinococcus granulosus carbonic anhydrase II 0.0147 0.0675 0.0675
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0108 0.1814
Schistosoma mansoni microtubule-associated protein tau 0.2075 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0594 0.0594
Onchocerca volvulus 0.001 0.0009 0.0019
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0055 0.0821
Schistosoma mansoni lamin 0.0027 0.0091 0.0091
Trichomonas vaginalis esterase, putative 0.0036 0.0136 0.0275
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0136 0.201
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0218 0.0504
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0108 0.2923
Trypanosoma brucei transcription factor BTF3, putative 0.007 0.03 0.4448
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0206 0.5584
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0588 0.2806 1
Brugia malayi intermediate filament protein 0.0027 0.0091 0.0211
Brugia malayi hypothetical protein 0.001 0.0009 0.0021
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0136 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0031 0.0062
Echinococcus multilocularis musashi 0.0027 0.0091 0.0091
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0009 0.0009
Trypanosoma brucei glucose transporter, putative 0.001 0.0009 0.0137
Schistosoma mansoni tensin-related 0.0008 0.0003 0.0003
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0136 0.1003
Loa Loa (eye worm) hypothetical protein 0.0179 0.0827 0.1911
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0055 0.0821
Loa Loa (eye worm) hypothetical protein 0.0023 0.0074 0.0172
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.2806 0.5694
Brugia malayi hypothetical protein 0.001 0.0009 0.0021
Onchocerca volvulus 0.0036 0.0136 0.0275
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0055 0.0128
Giardia lamblia Fructose-bisphosphate aldolase 0.0588 0.2806 1
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.011 0.0496 0.1147
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0114 0.0264
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0108 0.1814
Mycobacterium leprae Probable lipase LipE 0.0036 0.0136 0.1003
Onchocerca volvulus 0.001 0.0009 0.0019
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0123 0.1818
Brugia malayi SET domain containing protein 0.001 0.0009 0.0021
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0023 0.0345
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.05 0.1157
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.011 0.0496 0.0496
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0218 0.0218
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0033 0.0555
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0031 0.0073
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0136 0.201
Schistosoma mansoni SET domain protein 0.001 0.0009 0.0009
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0263 0.4427
Echinococcus multilocularis solute carrier family 22 0.001 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0031 0.0062
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0025 0.0025
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0023 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0055 0.0821
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0021
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0023 0.0345
Loa Loa (eye worm) hypothetical protein 0.0036 0.0136 0.0313
Brugia malayi beta-lactamase 0.0036 0.0136 0.0313
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0103 0.153
Trypanosoma brucei glucose transporter, putative 0.001 0.0009 0.0137
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0006 0.0014
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0108 0.1814
Schistosoma mansoni hypothetical protein 0.0031 0.0114 0.0114
Giardia lamblia Hexose transporter 0.001 0.0009 0.0033
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0103 0.153
Plasmodium falciparum glutathione reductase 0.0029 0.0103 0.2799
Echinococcus granulosus lamin 0.0027 0.0091 0.0091
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0213 0.0992 0.7343
Echinococcus multilocularis L aminoadipate semialdehyde 0.0179 0.0827 0.0827
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0027 0.0393
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0123 0.1818
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0055 0.0821
Onchocerca volvulus 0.001 0.0009 0.0019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0218 0.0218
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0055 0.041
Echinococcus multilocularis mitogen activated protein kinase 0.0103 0.0461 0.0461
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.05 0.7418
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0006
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.011 0.0496 0.0496
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.05 0.147
Loa Loa (eye worm) hypothetical protein 0.0131 0.0594 0.1373
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0103 0.153
Mycobacterium ulcerans sugar transporter 0.001 0.0009 0.0068
Echinococcus multilocularis protein numb 0.0008 0.0003 0.0003
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0034 0.057
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.001 0.0009 0.0068
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0103 0.0103
Toxoplasma gondii facilitative glucose transporter GT1 0.001 0.0009 0.0156
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0103 0.153
Onchocerca volvulus 0.001 0.0009 0.0019
Leishmania major glucose transporter/membrane transporter D2, putative 0.001 0.0009 0.0137
Brugia malayi Pre-SET motif family protein 0.0902 0.4326 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0079 0.0079
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0218 0.0504
Onchocerca volvulus 0.1026 0.4928 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0055 0.0112
Brugia malayi Sugar transporter family protein 0.001 0.0009 0.0021
Brugia malayi MAP kinase sur-1 0.0103 0.0461 0.1066
Loa Loa (eye worm) carbonic anhydrase 3 0.0147 0.0675 0.1559
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0108 0.0219
Echinococcus granulosus importin subunit beta 1 0.0033 0.0123 0.0123
Echinococcus multilocularis voltage dependent calcium channel 0.011 0.0496 0.0496
Leishmania major glucose transporter, lmgt1 0.001 0.0009 0.0137
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0092 0.1369
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0006 0.0101
Onchocerca volvulus 0.001 0.0009 0.0019
Schistosoma mansoni ran 0.0024 0.008 0.008
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0213 0.0992 0.7343
Echinococcus multilocularis solute carrier family 22 0.001 0.0009 0.0009
Leishmania major DNA polymerase eta, putative 0.0019 0.0055 0.0821
Plasmodium vivax hexose transporter 0.001 0.0009 0.0156
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0092 0.0187
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Brugia malayi Pre-SET motif family protein 0.0131 0.0594 0.1373
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.008 0.008
Loa Loa (eye worm) calcium channel 0.011 0.0496 0.1147
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0136 0.1003
Echinococcus multilocularis geminin 0.0501 0.2388 0.2388
Brugia malayi major facilitator superfamily protein 0.001 0.0009 0.0021
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0021
Echinococcus granulosus snurportin 1 0.0353 0.1673 0.1673
Loa Loa (eye worm) hypothetical protein 0.0076 0.0329 0.0761
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0103 0.153
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0147 0.0675 0.1559
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0108 0.0219
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0055 0.041
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0136 0.0275
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.05 0.1015
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.008 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0031 0.0062
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0034 0.0125 0.0288
Schistosoma mansoni sugar transporter 0.001 0.0009 0.0009
Echinococcus multilocularis carboxyl terminal PDZ ligand of neuronal nitric 0.0008 0.0003 0.0003
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0108 0.1814
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0114 0.0264
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0055 0.0821
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0263 0.1945
Schistosoma mansoni DNA helicase recq5 0.0009 0.0006 0.0006
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0055 0.041
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0031 0.0062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.2806 0.5694
Trichomonas vaginalis myo-inositol transporter, putative 0.001 0.0009 0.0019
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0009 0.0009
Brugia malayi TBC domain containing protein 0.0008 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0021
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0031 0.0062
Onchocerca volvulus 0.001 0.0009 0.0019
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0009 0.0009
Brugia malayi RNA, U transporter 1 0.0094 0.0418 0.0966
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0103 0.153
Giardia lamblia DINP protein human, muc B family 0.0019 0.0055 0.0197
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0131 0.0594 0.0594
Schistosoma mansoni hypothetical protein 0.0353 0.1673 0.1673
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0136 0.1003
Onchocerca volvulus 0.001 0.0009 0.0019
Mycobacterium ulcerans beta-lactamase 0.0036 0.0136 0.1003
Echinococcus granulosus synaptic vesicle 2 protein 0.001 0.0009 0.0009
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0006 0.0101
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.014
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0009 0.0019
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.008 0.1191
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0019 0.0279
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0136 0.1003
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0287 0.1351 1
Giardia lamblia Sugar-proton symporter 0.001 0.0009 0.0033
Echinococcus multilocularis carbonic anhydrase II 0.0147 0.0675 0.0675
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0014
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0006 0.0021
Brugia malayi Sugar transporter family protein 0.001 0.0009 0.0021
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0103 0.0209
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0092 0.0187
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0068 0.0068
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.05 0.1783
Plasmodium falciparum glutathione reductase 0.0084 0.0369 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0103 0.0368
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0263 0.0263
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0123 0.2065
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0055 0.0128
Echinococcus granulosus cpg binding protein 0.0066 0.0281 0.0281
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.005 0.0206 0.346
Toxoplasma gondii sugar transporter ST3 0.001 0.0009 0.0156
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Echinococcus granulosus mitogen activated protein kinase 0.0103 0.0461 0.0461
Schistosoma mansoni hypothetical protein 0.0501 0.2388 0.2388
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0115 0.0521 0.0521
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0124 0.0564 0.0564
Schistosoma mansoni carbonic anhydrase-related 0.0034 0.0125 0.0125
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0108 0.0384
Brugia malayi protein M110.5 0.0008 0.0003 0.0006
Toxoplasma gondii histone lysine methyltransferase SET1 0.0123 0.0557 0.9377
Loa Loa (eye worm) hypothetical protein 0.0036 0.0136 0.0313
Schistosoma mansoni hypothetical protein 0.0031 0.0114 0.0114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.2806 0.5694
Loa Loa (eye worm) hypothetical protein 0.0099 0.0442 0.1022
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.05 0.05
Loa Loa (eye worm) major facilitator superfamily transporter 0.001 0.0009 0.0021
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.008 0.1191
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0071 0.0304 0.0702
Echinococcus granulosus hypothetical protein 0.0008 0.0003 0.0003
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0136 0.0136
Echinococcus multilocularis voltage dependent calcium channel 0.011 0.0496 0.0496
Echinococcus multilocularis carbonic anhydrase 0.0034 0.0125 0.0125
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.011 0.0496 0.0496
Schistosoma mansoni carbonic anhydrase-related 0.0034 0.0125 0.0125
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0067 0.0287 0.4258
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0108 0.0384
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0115 0.0521 0.0521
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0179 0.0827 0.1911
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0009 0.0019
Echinococcus multilocularis synaptic vesicle 2 protein 0.001 0.0009 0.0009
Leishmania major hypothetical protein, conserved 0.005 0.0206 0.3051
Loa Loa (eye worm) hypothetical protein 0.005 0.0206 0.0476
Plasmodium vivax thioredoxin reductase, putative 0.0084 0.0369 0.6206
Plasmodium vivax sugar transporter, putative 0.001 0.0009 0.0156
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0025 0.0025
Leishmania major basic transcription factor 3a, putative 0.007 0.03 0.4448
Echinococcus granulosus transcription factor btf3 0.007 0.03 0.03
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0136 0.2283
Onchocerca volvulus 0.001 0.0009 0.0019
Mycobacterium tuberculosis Conserved protein 0.0036 0.0136 0.1003
Echinococcus multilocularis solute carrier family 22 0.001 0.0009 0.0009
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.05 0.3702
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0115 0.0521 0.3852
Loa Loa (eye worm) X11 protein 0.0079 0.0344 0.0795
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Brugia malayi Sugar transporter family protein 0.001 0.0009 0.0021
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.011 0.0496 0.1147
Schistosoma mansoni carbonic anhydrase-related 0.0034 0.0125 0.0125
Echinococcus granulosus carbonic anhydrase 0.0034 0.0125 0.0125
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0007 0.0107
Onchocerca volvulus 0.001 0.0009 0.0019
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Brugia malayi hypothetical protein 0.0008 0.0003 0.0006
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0103 0.0461 0.6837
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0031 0.0062
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.014
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Echinococcus granulosus Solute carrier family 22 5 0.1023 0.491 0.491
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.008 0.0186
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0115 0.0521 0.0521
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0136 0.0136
Echinococcus multilocularis Sugar transporter ERD6 protein 0.001 0.0009 0.0009
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0103 0.0763
Loa Loa (eye worm) histone methyltransferase 0.0024 0.0079 0.0182
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0206 0.5584
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0103 0.1737
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0009 0.0019
Echinococcus granulosus Sugar transporter ERD6 protein 0.001 0.0009 0.0009
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0461 0.6837
Leishmania major myo-inositol/proton symporter (MIT) 0.001 0.0009 0.0137
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.2806 0.5694
Loa Loa (eye worm) hypothetical protein 0.0019 0.0055 0.0128
Onchocerca volvulus 0.0008 0.0003 0.0006
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Leishmania major cytochrome p450-like protein 0.0013 0.0023 0.0345
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0006 0.0006
Toxoplasma gondii sugar transporter ST2 0.001 0.0009 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0031 0.0062
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.0461 0.6837
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0147 0.0675 0.0675
Echinococcus granulosus histone lysine methyltransferase setb 0.0131 0.0594 0.0594
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0031 0.0062
Loa Loa (eye worm) POT family protein 0.0081 0.0352 0.0815
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.008 0.1191
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0052
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0031 0.0062
Schistosoma mansoni amyloid beta A4 protein related 0.0079 0.0344 0.0344
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0103 0.1737
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0055 0.0055
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0108 0.0447
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0021
Echinococcus multilocularis lamin dm0 0.0027 0.0091 0.0091
Echinococcus granulosus carbonic anhydrase 0.0034 0.0125 0.0125
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0055 0.0821
Echinococcus granulosus thioredoxin glutathione reductase 0.0084 0.0371 0.0371
Onchocerca volvulus 0.001 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0021
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0103 0.1737
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0264 0.0611
Trypanosoma cruzi hexose transporter, putative 0.001 0.0009 0.0137
Brugia malayi Cytochrome P450 family protein 0.0013 0.0023 0.0054
Onchocerca volvulus 0.0179 0.0827 0.1678
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0009 0.0009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0218 0.0218
Plasmodium vivax glutathione reductase, putative 0.0084 0.0369 0.6206
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0031 0.0062
Giardia lamblia Kinase, CMGC MAPK 0.0103 0.0461 0.1644
Echinococcus granulosus voltage dependent calcium channel 0.011 0.0496 0.0496
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0103 0.153
Brugia malayi beta-NAC-like protein 0.007 0.03 0.0694
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.005 0.0206 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0136 0.0136
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0055 0.0821
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.001 0.0009 0.0009
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0461 0.0936
Trypanosoma cruzi hexose transporter, putative 0.001 0.0009 0.0137
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0263 0.3898
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0006 0.0006
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.05 0.7418
Mycobacterium tuberculosis Conserved protein 0.0036 0.0136 0.1003
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0103 0.0461 0.6837
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0055 0.0821
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0009 0.0137
Schistosoma mansoni carbonic anhydrase 0.0034 0.0125 0.0125
Onchocerca volvulus 0.001 0.0009 0.0019
Schistosoma mansoni hypothetical protein 0.0068 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0006
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.05 0.05
Mycobacterium ulcerans lipase LipD 0.0036 0.0136 0.1003
Schistosoma mansoni glucose transport protein 0.001 0.0009 0.0009
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0031 0.0114 0.0114
Echinococcus granulosus dna polymerase kappa 0.0019 0.0055 0.0055
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0461 0.0936
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0136 0.0275
Echinococcus multilocularis dna polymerase eta 0.0019 0.0055 0.0055
Schistosoma mansoni sugar transporter 0.001 0.0009 0.0009
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0192 0.0889 0.6578
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.05 0.1783
Trichomonas vaginalis helicase, putative 0.0014 0.0031 0.0062
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.001 0.0009 0.0137
Loa Loa (eye worm) hypothetical protein 0.0031 0.0114 0.0264
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.008 0.008
Onchocerca volvulus 0.0036 0.0136 0.0275
Loa Loa (eye worm) sugar transporter 0.001 0.0009 0.0021
Schistosoma mansoni glucose transport protein 0.001 0.0009 0.0009
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0092 0.0187
Trypanosoma cruzi hexose transporter, putative 0.001 0.0009 0.0137
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0021
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.006 0.006
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0055 0.041
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0055 0.0128
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.005 0.0206 0.346
Loa Loa (eye worm) hypothetical protein 0.0017 0.0047 0.0108
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0029 0.0029
Plasmodium vivax basic transcription factor 3b, putative 0.007 0.03 0.5052
Onchocerca volvulus 0.0062 0.0264 0.0536
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0114 0.0114
Treponema pallidum 4'-phosphopantetheinyl transferase 0.005 0.0206 0.0379
Onchocerca volvulus 0.001 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0021
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0206 0.3051
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0021
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.05 0.05
Echinococcus granulosus geminin 0.0501 0.2388 0.2388
Echinococcus multilocularis amyloid beta A4 protein 0.0079 0.0344 0.0344
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0108 0.1814
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0055 0.0112
Entamoeba histolytica transcription factor BTF3, putative 0.007 0.03 0.1069
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.008 0.1352
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0131 0.0594 0.0594
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0103 0.0461 0.6837
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.006 0.006
Leishmania major phosphopantetheinyl transferase-like protein 0.005 0.0206 0.3047
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0103 0.153
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0103 0.153
Trypanosoma brucei glucose transporter, putative 0.001 0.0009 0.0137
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.05 0.3702
Schistosoma mansoni transcription factor btf3 0.007 0.03 0.03
Schistosoma mansoni ran 0.0024 0.008 0.008
Schistosoma mansoni cpg binding protein 0.0066 0.0281 0.0281
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0055 0.0055
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0031 0.0062
Schistosoma mansoni shc transforming protein 0.0008 0.0003 0.0003
Schistosoma mansoni numb 0.0008 0.0003 0.0003
Echinococcus granulosus solute carrier family 22 0.001 0.0009 0.0009
Loa Loa (eye worm) RecQ helicase 0.0022 0.0068 0.0157
Schistosoma mansoni hypothetical protein 0.0501 0.2388 0.2388
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0055 0.0821
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0103 0.0103
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0103 0.2799
Entamoeba histolytica hypothetical protein 0.0027 0.0092 0.0329
Toxoplasma gondii NAC domain-containing protein 0.007 0.03 0.5052
Entamoeba histolytica hypothetical protein 0.007 0.03 0.1069
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Trichomonas vaginalis glucose transporter, putative 0.001 0.0009 0.0019
Brugia malayi Importin beta-1 subunit 0.0033 0.0123 0.0283
Onchocerca volvulus 0.001 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0021
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Loa Loa (eye worm) ICD-1 protein 0.007 0.03 0.0694
Echinococcus multilocularis cpg binding protein 0.0066 0.0281 0.0281
Plasmodium vivax SET domain protein, putative 0.0131 0.0594 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.0055 0.0055
Brugia malayi beta-lactamase family protein 0.0036 0.0136 0.0313
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0136 0.0313
Brugia malayi hypothetical protein 0.0076 0.0329 0.0761
Onchocerca volvulus 0.001 0.0009 0.0019
Onchocerca volvulus Putative transporter 0.001 0.0009 0.0019
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0031 0.0062
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.05 0.1015
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0023 0.0345
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.005 0.0206 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0031 0.0062
Echinococcus multilocularis lamin 0.0027 0.0091 0.0091
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0021
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0108 0.0219
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0902 0.4326 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.0023 0.0172
Schistosoma mansoni importin beta-1 0.0033 0.0123 0.0123
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.05 0.1015
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0034 0.0125 0.0288
Leishmania major DNA polymerase kappa, putative 0.0019 0.0055 0.0821
Trypanosoma brucei protein kinase, putative 0.0103 0.0461 0.6837
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0009 0.0009
Plasmodium falciparum thioredoxin reductase 0.0029 0.0103 0.2799
Schistosoma mansoni DNA helicase recq1 0.0009 0.0006 0.0006
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0147 0.0675 0.1559
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Trypanosoma brucei carbonic anhydrase-like protein 0.0147 0.0675 1
Plasmodium falciparum basic transcription factor 3b, putative 0.007 0.03 0.814
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.011 0.0496 0.0496
Onchocerca volvulus 0.001 0.0009 0.0019
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0055 0.0821
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0021
Trypanosoma brucei sugar transporter, putative 0.001 0.0009 0.0137
Loa Loa (eye worm) thioredoxin reductase 0.0084 0.0369 0.0852
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0137 0.0625 0.0625
Leishmania major GTP-binding protein, putative 0.0024 0.008 0.1191
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0031 0.0073
Echinococcus multilocularis mitogen activated protein kinase 3 0.0103 0.0461 0.0461
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.001 0.0009 0.0068
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0091 0.0211
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.05 0.3702
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0218 0.0218
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0108 0.0219
Echinococcus multilocularis carbonic anhydrase 0.0034 0.0125 0.0125
Schistosoma mansoni hypothetical protein 0.0008 0.0003 0.0003
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0055 0.0821
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0055 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0027 0.0393
Echinococcus granulosus mixed lineage leukemia protein mll 0.002 0.006 0.006
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0023 0.0054
Echinococcus granulosus lamin dm0 0.0027 0.0091 0.0091
Brugia malayi phosphofructokinase 0.0111 0.05 0.1157
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0031 0.0062
Leishmania major carbonic anhydrase-like protein 0.0147 0.0675 1
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.001 0.0009 0.0068
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0136 0.0313
Trypanosoma cruzi glucose transporter, putative 0.001 0.0009 0.0137
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0263 0.1945
Trichomonas vaginalis set domain proteins, putative 0.1026 0.4928 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0213 0.0992 0.7343
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.005 0.0206 0.346
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0034 0.0125 0.0288
Mycobacterium ulcerans hypothetical protein 0.0036 0.0136 0.1003
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0192 0.0889 0.6578
Loa Loa (eye worm) hypothetical protein 0.0036 0.0136 0.0313
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0147 0.0675 0.0675
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.2806 0.5694
Schistosoma mansoni intermediate filament proteins 0.0027 0.0091 0.0091
Plasmodium falciparum importin beta, putative 0.0033 0.0123 0.3327
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0131 0.0594 0.0594
Trypanosoma cruzi hexose transporter 0.001 0.0009 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0055 0.0821
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0055 0.0197
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0442 0.1022
Trichomonas vaginalis glucose transporter, putative 0.001 0.0009 0.0019
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.006 0.006
Brugia malayi CED-6 protein 0.0008 0.0003 0.0006
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0066 0.0152
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0068 0.0138
Schistosoma mansoni lamin 0.0027 0.0091 0.0091
Plasmodium vivax importin-beta 2, putative 0.0033 0.0123 0.2065
Brugia malayi 6-phosphofructokinase 0.0111 0.05 0.1157
Schistosoma mansoni cpg binding protein 0.0062 0.0264 0.0264
Trichomonas vaginalis sugar transport protein, putative 0.001 0.0009 0.0019
Toxoplasma gondii hypothetical protein 0.002 0.0061 0.1022
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0103 0.1737
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0006
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0108 0.0219
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0103 0.0209
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0218 0.0218
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Plasmodium falciparum carbonic anhydrase 0.0034 0.0125 0.3385
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0078 0.0179
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0055 0.0821
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0031 0.0062
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0103 0.0103
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.008 0.1352
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0114 0.0114
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0461 0.0461
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0108 0.0447
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.2806 0.5694
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0072 0.0072
Trypanosoma brucei glucose transporter, putative 0.001 0.0009 0.0137
Brugia malayi beta-lactamase family protein 0.0036 0.0136 0.0313
Loa Loa (eye worm) glutathione reductase 0.0084 0.0369 0.0852
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0006
Loa Loa (eye worm) sugar transporter 0.001 0.0009 0.0021
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.0057
Mycobacterium ulcerans integral membrane transport protein 0.001 0.0009 0.0068
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0046 0.0046
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0263 0.0263
Onchocerca volvulus 0.001 0.0009 0.0019
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.011 0.0496 0.0496
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0263 0.0263
Echinococcus granulosus bloom syndrome protein 0.0022 0.0068 0.0068
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0103 0.0461 0.6837
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0047 0.0189 0.0189
Leishmania major hypothetical protein, conserved 0.001 0.0009 0.0137
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0588 0.2806 0.5694
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0009 0.0019
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0192 0.0889 0.6578
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0114 0.0114
Toxoplasma gondii hypothetical protein 0.0034 0.0125 0.2101
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0027 0.0393
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0009 0.0021
Trypanosoma cruzi sugar transporter, putative 0.001 0.0009 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.007 0.03 0.0609
Schistosoma mansoni sugar transporter 0.001 0.0009 0.0009
Trypanosoma cruzi trypanothione reductase, putative 0.0084 0.0369 0.5464
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0114 0.0264
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0136 0.1003
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.001 0.0009 0.0009
Echinococcus multilocularis carbonic anhydrase 0.0034 0.0125 0.0125
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0103 0.5021
Echinococcus multilocularis sodium channel protein 0.0047 0.0189 0.0189
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0055 0.0821
Leishmania major hypothetical protein, conserved 0.0009 0.0007 0.0107
Trypanosoma brucei trypanothione reductase 0.0084 0.0369 0.5464
Trypanosoma brucei glucose transporter, putative 0.001 0.0009 0.0137
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0115 0.0521 0.7717
Onchocerca volvulus 0.0131 0.0594 0.1205
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0072 0.0072
Echinococcus granulosus mitogen activated protein kinase 3 0.0103 0.0461 0.0461
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0019 0.0038
Entamoeba histolytica Ran family GTPase 0.0024 0.008 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0009 0.0019
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.005 0.0206 0.5575
Loa Loa (eye worm) hypothetical protein 0.0036 0.0136 0.0313
Echinococcus multilocularis snurportin 1 0.0353 0.1673 0.1673
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0006 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0007 0.0107
Echinococcus granulosus solute carrier family 22 0.001 0.0009 0.0009
Toxoplasma gondii transporter, cation channel family protein 0.0023 0.0074 0.125
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0103 0.0239
Echinococcus granulosus L aminoadipate semialdehyde 0.0179 0.0827 0.0827
Loa Loa (eye worm) voltage-dependent calcium channel 0.0023 0.0074 0.0172
Schistosoma mansoni hypothetical protein 0.0034 0.0125 0.0125
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0103 0.0461 0.1066
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0031 0.0062
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0006
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0136 0.0136
Plasmodium falciparum thioredoxin reductase 0.0084 0.0369 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0147 0.0675 1
Trypanosoma cruzi hexose transporter, putative 0.001 0.0009 0.0137
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0442 0.1022
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.008 0.2179
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0108 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0594 0.0594
Trypanosoma brucei glucose transporter 2A 0.001 0.0009 0.0137
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0263 0.0263
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0136 0.1003
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.001 0.0009 0.0251
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0136 0.1003
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.0461 0.0936
Brugia malayi AIDA-1b 0.0008 0.0003 0.0006
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.05 0.1157
Mycobacterium tuberculosis Probable dehydrogenase 0.0192 0.0889 0.6578
Leishmania major glucose transporter, lmgt3 0.001 0.0009 0.0137
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.011 0.0496 0.0496
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0206 0.3466
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0115 0.0521 0.3852
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0021
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0021
Loa Loa (eye worm) beta-lactamase 0.0036 0.0136 0.0313
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0055 0.1498
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0006 0.0014
Trypanosoma brucei THT1 - hexose transporter, putative 0.001 0.0009 0.0137
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0108 0.0483 0.1116
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0103 0.153
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0147 0.0675 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0213 0.0992 0.7343
Trypanosoma brucei hypothetical protein, conserved 0.005 0.0206 0.3047
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0052
Loa Loa (eye worm) hypothetical protein 0.0034 0.0125 0.0288
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0068 0.0157
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0147 0.0675 0.1559
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0103 0.153
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0103 0.153
Loa Loa (eye worm) hypothetical protein 0.0034 0.0125 0.0288
Brugia malayi 6-phosphofructokinase 0.0111 0.05 0.1157
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0055 0.0821
Brugia malayi hypothetical protein 0.005 0.0206 0.0476
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0136 0.0275
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0136 0.201
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0103 0.0763
Toxoplasma gondii sugar transporter ST1 0.001 0.0009 0.0156
Schistosoma mansoni glucose transporter 0.001 0.0009 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0136 0.0275
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0055 0.0821
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0006 0.0163
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.008 0.0286
Entamoeba histolytica hypothetical protein 0.005 0.0206 0.0732
Loa Loa (eye worm) hypothetical protein 0.0033 0.0123 0.0283
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0006 0.0006
Brugia malayi Thioredoxin reductase 0.0084 0.0369 0.0852
Schistosoma mansoni cpg binding protein 0.0066 0.0281 0.0281
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0068 0.0138
Echinococcus multilocularis transcription factor btf3 0.007 0.03 0.03
Schistosoma mansoni glucose transport protein 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0089 0.0206
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0079 0.0079
Mycobacterium leprae conserved hypothetical protein 0.005 0.0206 0.1521
Schistosoma mansoni hypothetical protein 0.0031 0.0114 0.0114
Echinococcus granulosus dna polymerase eta 0.0019 0.0055 0.0055
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0103 0.2799
Mycobacterium tuberculosis Conserved protein 0.0036 0.0136 0.1003
Onchocerca volvulus 0.0027 0.0091 0.0185
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.029 0.0671
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Echinococcus granulosus GPCR family 2 0.0031 0.0114 0.0114
Leishmania major glucose transporter, lmgt2 0.001 0.0009 0.0137
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0019 0.0067
Echinococcus multilocularis GPCR, family 2 0.0031 0.0114 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.007 0.03 0.0609
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0103 0.0763
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0136 0.1003
Schistosoma mansoni voltage-gated cation channel 0.011 0.0496 0.0496
Onchocerca volvulus 0.0027 0.0091 0.0185
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.1069 0.7908
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Echinococcus multilocularis mixed lineage leukemia protein mll 0.002 0.006 0.006
Trichomonas vaginalis glucose transporter, putative 0.001 0.0009 0.0019
Leishmania major trypanothione reductase 0.0084 0.0369 0.5464
Echinococcus granulosus solute carrier family 22 0.001 0.0009 0.0009
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0084 0.0369 0.2727
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0021
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0034 0.0125 0.0288
Trypanosoma brucei glucose transporter, putative 0.001 0.0009 0.0137
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0123 0.0123
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0091 0.0211
Brugia malayi CXXC zinc finger family protein 0.0062 0.0264 0.0611
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0206 0.3051
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0009 0.0019
Onchocerca volvulus 0.001 0.0009 0.0019
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0091 0.0211
Loa Loa (eye worm) phosphofructokinase 0.0111 0.05 0.1157
Echinococcus granulosus carboxyl terminal PDZ ligand of neuronal nitric 0.0008 0.0003 0.0003
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0103 0.153
Plasmodium falciparum hexose transporter 0.001 0.0009 0.0251
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0103 0.5021
Echinococcus granulosus carbonic anhydrase 0.0034 0.0125 0.0125
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0103 0.153
Brugia malayi hypothetical protein 0.001 0.0009 0.0021
Trypanosoma brucei glucose transporter, putative 0.001 0.0009 0.0137
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0108 0.0219
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0021
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.001 0.0009 0.0009
Brugia malayi POT family protein 0.0081 0.0352 0.0815
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Trypanosoma brucei unspecified product 0.0013 0.0027 0.0393
Echinococcus multilocularis thioredoxin glutathione reductase 0.0084 0.0371 0.0371
Trichomonas vaginalis ran, putative 0.0024 0.008 0.0163
Loa Loa (eye worm) hypothetical protein 0.0036 0.0136 0.0313
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0006
Trichomonas vaginalis sugar transporter, putative 0.001 0.0009 0.0019
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0287 0.1351 1
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.05 0.1015
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0067 0.0287 0.4258
Loa Loa (eye worm) hypothetical protein 0.0027 0.0091 0.0211
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0009 0.0021
Echinococcus multilocularis solute carrier family 22 0.001 0.0009 0.0009
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0103 0.0461 0.6837
Echinococcus granulosus intermediate filament protein 0.0027 0.0091 0.0091
Brugia malayi Major Facilitator Superfamily protein 0.001 0.0009 0.0021
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0114 0.0114

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.13 uM Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assay ChEMBL. 15771438
IC50 (binding) = 0.13 uM Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assay ChEMBL. 15771438
Kd (binding) = 140 nM Binding affinity to human CA2 by ThermoFluor assay ChEMBL. 16759092
Kd (binding) = 140 nM Binding affinity to human CA2 by ThermoFluor assay ChEMBL. 16759092

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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