Detailed information for compound 329518

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 284.353 | Formula: C17H20N2O2
  • H donors: 0 H acceptors: 1 LogP: 2.07 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccn1C)C(c1ccccc1)N1CCOCC1
  • InChi: 1S/C17H20N2O2/c1-18-9-5-8-15(18)17(20)16(14-6-3-2-4-7-14)19-10-12-21-13-11-19/h2-9,16H,10-13H2,1H3
  • InChiKey: GLRWRCKFRUZWGS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Monoamine oxidase A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) Get druggable targets OG5_130722 All targets in OG5_130722
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH Get druggable targets OG5_130722 All targets in OG5_130722
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH Get druggable targets OG5_130722 All targets in OG5_130722
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Monoamine oxidase A   526 aa 524 aa 22.9 %
Brugia malayi amine oxidase, flavin-containing family protein Monoamine oxidase A   526 aa 464 aa 21.6 %
Dictyostelium discoideum hypothetical protein Monoamine oxidase A   526 aa 518 aa 22.4 %
Dictyostelium discoideum amine oxidase Monoamine oxidase A   526 aa 491 aa 31.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ORL1-like opioid receptor 0.0011 0.0001 0.0001
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0206 0.0734 0.5279
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0042 0.0041
Leishmania major heat shock protein 83-1 0.0053 0.0159 0.1041
Leishmania major mitochondrial DNA polymerase beta 0.0206 0.0734 0.5279
Echinococcus granulosus GPCR family 2 0.0013 0.0008 0.0007
Echinococcus granulosus lysine specific histone demethylase 1A 0.0025 0.0053 0.0053
Plasmodium vivax hypothetical protein, conserved 0.0452 0.1663 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0452 0.1663 0.1662
Echinococcus granulosus expressed conserved protein 0.014 0.0487 0.0486
Echinococcus multilocularis short transient receptor potential channel 6 0.0044 0.0123 0.0122
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0024 0.0049 0.0048
Toxoplasma gondii NAC domain-containing protein 0.0024 0.0048 0.0181
Leishmania major heat shock protein 83-1 0.0053 0.0159 0.1041
Brugia malayi Calcitonin receptor-like protein seb-1 0.0042 0.0115 0.0115
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0097 0.0325 0.2265
Brugia malayi Hsp90 protein 0.003 0.0071 0.0071
Echinococcus multilocularis muscleblind protein 1 0.0346 0.1265 0.1264
Echinococcus granulosus TRP transient receptor potential channel 0.0025 0.0051 0.005
Schistosoma mansoni amine oxidase 0.0025 0.0053 0.0053
Brugia malayi RNA binding protein 0.0043 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0452 0.1663 0.1662
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0042 0.0041
Chlamydia trachomatis protoporphyrinogen oxidase 0.0025 0.0053 0.0214
Echinococcus granulosus GA binding protein alpha chain 0.0049 0.0144 0.0143
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0452 0.1663 0.1663
Loa Loa (eye worm) TAR-binding protein 0.0043 0.0121 0.012
Entamoeba histolytica hypothetical protein 0.0055 0.0164 0.2896
Echinococcus multilocularis peregrin 0.0026 0.0058 0.0057
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0053 0.0214
Trichomonas vaginalis set domain proteins, putative 0.0163 0.0573 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0023 0.0032
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0018 0.0025 0.0018
Plasmodium falciparum heat shock protein 90, putative 0.0127 0.0439 0.2556
Schistosoma mansoni biogenic amine (5HT) receptor 0.0135 0.0469 0.0468
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0042 0.0041
Trypanosoma cruzi transcription factor btf3, putative 0.0024 0.0048 0.0188
Brugia malayi Serotonin receptor 0.0011 0.0001 0.0001
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0452 0.1663 0.1662
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0452 0.1663 0.1662
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0038 0.0038
Echinococcus multilocularis histone acetyltransferase MYST2 0.0037 0.0098 0.0097
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0042 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0083 0.0273 0.0272
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0042 0.0042
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0025 0.0053 0.0053
Schistosoma mansoni microtubule-associated protein tau 0.047 0.1732 0.1731
Echinococcus granulosus Protein patched homolog 1 0.0064 0.02 0.0199
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0047 0.0135 0.0977
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0023 0.0022
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0042 0.0041
Trypanosoma brucei heat shock protein, putative 0.0053 0.0159 0.1041
Mycobacterium tuberculosis Conserved hypothetical protein 0.0025 0.0053 0.0294
Echinococcus multilocularis GA binding protein alpha chain 0.0049 0.0144 0.0143
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0002 0.0002
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Echinococcus multilocularis geminin 0.0115 0.0394 0.0393
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0042 0.0041
Brugia malayi MH2 domain containing protein 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0022 0.0043 0.0042
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0023 0.0047 0.0172
Entamoeba histolytica hypothetical protein 0.0055 0.0164 0.2896
Onchocerca volvulus 0.0025 0.0053 0.0053
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0023 0.0027
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.2662 1 1
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0023 0.0022
Echinococcus multilocularis neuropeptide receptor A26 0.0325 0.1183 0.1182
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0023 0.0027
Echinococcus granulosus sodium and chloride dependent glycine 0.0452 0.1663 0.1662
Entamoeba histolytica heat shock protein 90, putative 0.0053 0.0159 0.2808
Schistosoma mansoni tar DNA-binding protein 0.0043 0.0121 0.012
Brugia malayi jmjC domain containing protein 0.0017 0.0023 0.0023
Brugia malayi N-terminal motif family protein 0.0151 0.0526 0.0526
Schistosoma mansoni sex comb on midleg homolog 0.0032 0.0081 0.008
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0024 0.0049 0.0048
Loa Loa (eye worm) endoplasmin 0.0053 0.0159 0.0159
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0042 0.0041
Echinococcus multilocularis heat shock protein 0.0053 0.0159 0.0159
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0012 0.0005 0.0004
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0032 0.0081 0.008
Echinococcus multilocularis 0.0025 0.0053 0.0053
Brugia malayi Fli-1 protein 0.015 0.0523 0.0523
Brugia malayi hypothetical protein 0.0161 0.0566 0.0566
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0032 0.0081 0.008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0022
Trypanosoma brucei heat shock protein, putative 0.0053 0.0159 0.1041
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0452 0.1663 0.1662
Echinococcus granulosus mixed lineage leukemia protein mll 0.0012 0.0005 0.0004
Brugia malayi sulfakinin receptor protein 0.0011 0.0001 0.0001
Trichomonas vaginalis heat shock protein, putative 0.0036 0.0095 0.1273
Leishmania major UDP-galactopyranose mutase 0.0025 0.0053 0.0259
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0023 0.0047 0.0177
Loa Loa (eye worm) latrophilin receptor protein 2 0.0013 0.0008 0.0007
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0209 0.0208
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0042 0.0041
Plasmodium vivax JmjC domain containing protein 0.0017 0.0023 0.0027
Brugia malayi Tachykinin-like peptides receptor 99D 0.0011 0.0001 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0031 0.0076 0.0075
Schistosoma mansoni cpg binding protein 0.0044 0.0122 0.0121
Echinococcus granulosus lamin dm0 0.0018 0.0027 0.0027
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0304 0.0303
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0071 0.0386
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0452 0.1663 0.1662
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0029 0.0028
Schistosoma mansoni hypothetical protein 0.002 0.0033 0.0032
Echinococcus granulosus lamin 0.0018 0.0027 0.0027
Loa Loa (eye worm) transcription factor SMAD2 0.0181 0.0641 0.064
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0023 0.0022
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0011 0.0001 0.0001
Leishmania major heat shock protein 83-1 0.0053 0.0159 0.1041
Onchocerca volvulus Huntingtin homolog 0.0083 0.0273 0.0272
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0012 0.0005 0.0004
Loa Loa (eye worm) flap endonuclease-1 0.0018 0.0025 0.0024
Brugia malayi Melatonin receptor type 1A 0.0011 0.0001 0.0001
Echinococcus granulosus geminin 0.0115 0.0394 0.0393
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0013 0.0008 0.0008
Brugia malayi AKH receptor 0.0011 0.0001 0.0001
Echinococcus multilocularis serotonin transporter 0.2662 1 1
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Brugia malayi neuropeptide F receptor 0.0011 0.0001 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0043 0.0121 0.012
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0042 0.0041
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0042 0.0041
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0452 0.1663 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0022
Schistosoma mansoni hypothetical protein 0.0115 0.0394 0.0393
Schistosoma mansoni smad 0.0012 0.0005 0.0004
Brugia malayi G-protein coupled receptor 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0452 0.1663 0.1662
Brugia malayi Flap endonuclease-1 0.0018 0.0025 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0042 0.0042
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0025 0.0053 0.0272
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0005 0.0004
Echinococcus granulosus polycomb protein SCMH1 0.0032 0.0081 0.008
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0023 0.0022
Schistosoma mansoni cpg binding protein 0.0046 0.0132 0.0131
Loa Loa (eye worm) hypothetical protein 0.0042 0.0117 0.0116
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0041
Brugia malayi G-protein coupled receptor 0.0011 0.0001 0.0001
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0125 0.183
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0033 0.0032
Schistosoma mansoni transient receptor potential channel 0.0044 0.0123 0.0122
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0025 0.0053 0.0214
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0022 0.0041 0.004
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0333 0.1216 1
Plasmodium falciparum amino acid transporter, putative 0.0452 0.1663 1
Schistosoma mansoni tar DNA-binding protein 0.0043 0.0121 0.012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0041
Echinococcus granulosus flap endonuclease 1 0.0018 0.0025 0.0024
Brugia malayi nuclear hormone receptor 0.0022 0.0042 0.0042
Mycobacterium ulcerans hypothetical protein 0.0108 0.0367 0.2697
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0452 0.1663 0.1663
Loa Loa (eye worm) hypothetical protein 0.0066 0.0208 0.0207
Leishmania major heat shock protein 83-1 0.0053 0.0159 0.1041
Brugia malayi CXXC zinc finger family protein 0.0044 0.0122 0.0122
Plasmodium falciparum transporter, putative 0.0452 0.1663 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0013 0.0008 0.0007
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0025 0.0053 0.0053
Leishmania major heat shock protein 83-1 0.0053 0.0159 0.1041
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0032
Echinococcus granulosus biogenic amine 5HT receptor 0.0135 0.0469 0.0468
Trypanosoma cruzi Heat shock protein 83, putative 0.0053 0.0159 0.1012
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0452 0.1663 0.1662
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0023 0.0022
Echinococcus granulosus PHD finger protein rhinoceros 0.002 0.0033 0.0032
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0452 0.1663 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0172 0.0171
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0033 0.009
Toxoplasma gondii histone lysine methyltransferase SET1 0.0084 0.0275 0.156
Brugia malayi GnHR receptor homolog 0.0011 0.0001 0.0001
Trichomonas vaginalis heat shock protein, putative 0.0053 0.0159 0.2451
Echinococcus granulosus histone acetyltransferase MYST2 0.0037 0.0098 0.0097
Brugia malayi G protein-coupled receptor 0.0011 0.0001 0.0001
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0023 0.0047 0.0177
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0206 0.0734 0.5264
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0007
Trypanosoma brucei C-8 sterol isomerase, putative 0.0375 0.1375 1
Schistosoma mansoni lamin 0.0018 0.0027 0.0027
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0033 0.009
Brugia malayi jmjC domain containing protein 0.0017 0.0023 0.0023
Brugia malayi Dopamine receptor protein 1 0.0011 0.0001 0.0001
Loa Loa (eye worm) heat shock protein 90 0.0053 0.0159 0.0159
Leishmania major hypothetical protein, conserved 0.0017 0.0023 0.0035
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Brugia malayi Intermediate filament tail domain containing protein 0.0018 0.0027 0.0027
Echinococcus granulosus Smad4 0.0012 0.0005 0.0004
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0055 0.0164 0.0163
Toxoplasma gondii hypothetical protein 0.0452 0.1663 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0029 0.0067 0.033
Plasmodium falciparum heat shock protein 90 0.0053 0.0159 0.0858
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0023 0.0047 0.0046
Trypanosoma brucei heat shock protein, putative 0.0053 0.0159 0.1041
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0448 0.165 0.1649
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0042 0.0041
Schistosoma mansoni transient receptor potential channel 0.0066 0.0208 0.0207
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Trypanosoma brucei PAB1-binding protein , putative 0.0017 0.0023 0.0035
Trypanosoma brucei heat shock protein 90, putative 0.0053 0.0159 0.1041
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0375 0.1375 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0452 0.1663 0.1662
Brugia malayi Ets-domain containing protein 0.0049 0.0144 0.0144
Echinococcus multilocularis sodium and chloride dependent glycine 0.0452 0.1663 0.1662
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0013 0.0008 0.0007
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0057 0.0172 0.0171
Echinococcus granulosus microtubule associated protein 2 0.047 0.1732 0.1731
Loa Loa (eye worm) hypothetical protein 0.0452 0.1663 0.1662
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0041 0.004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0042 0.0042
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0029 0.0067 0.033
Loa Loa (eye worm) hypothetical protein 0.0346 0.1265 0.1264
Brugia malayi putative neuropeptide receptor NPR1 0.0011 0.0001 0.0001
Mycobacterium ulcerans heat shock protein 90 0.0047 0.0135 0.0905
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0047 0.0135 0.0862
Loa Loa (eye worm) MH1 domain-containing protein 0.0012 0.0005 0.0004
Brugia malayi beta-NAC-like protein 0.0024 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0062 0.0191 0.019
Loa Loa (eye worm) hypothetical protein 0.2662 1 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0254 0.0253
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Brugia malayi G protein-coupled receptor F59B2.13 0.0011 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0007
Echinococcus granulosus histone lysine methyltransferase setb 0.0022 0.0041 0.004
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0105 0.0355 0.0354
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0042 0.0041
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0015 0.0014
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0029 0.0067 0.033
Echinococcus granulosus tar DNA binding protein 0.0043 0.0121 0.012
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0025 0.0053 0.0214
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0047 0.0135 1
Loa Loa (eye worm) hypothetical protein 0.0346 0.1265 0.1264
Giardia lamblia Heat shock protein HSP 90-alpha 0.0053 0.0159 1
Plasmodium vivax basic transcription factor 3b, putative 0.0024 0.0048 0.0181
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0042 0.0041
Echinococcus multilocularis sterol regulatory element binding protein 0.0064 0.02 0.0199
Schistosoma mansoni intermediate filament proteins 0.0018 0.0027 0.0027
Echinococcus granulosus lysine specific demethylase 5A 0.0067 0.0209 0.0208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0042 0.0041
Brugia malayi Latrophilin receptor protein 2 0.0013 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0452 0.1663 0.1662
Loa Loa (eye worm) hypothetical protein 0.0149 0.0521 0.052
Echinococcus multilocularis serotonin receptor 0.0135 0.0469 0.0468
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0055 0.0164 0.0163
Loa Loa (eye worm) isocitrate dehydrogenase 0.0023 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0025 0.0053 0.0053
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0042 0.0041
Brugia malayi CHE-14 protein 0.0064 0.02 0.02
Brugia malayi Isocitrate dehydrogenase 0.0023 0.0047 0.0047
Schistosoma mansoni smad1 5 8 and 0.0012 0.0005 0.0004
Leishmania major heat shock protein 83-1 0.0053 0.0159 0.1041
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Schistosoma mansoni coup transcription factor 0.0022 0.0042 0.0041
Echinococcus multilocularis heat shock protein 90 0.0053 0.0159 0.0159
Schistosoma mansoni transient receptor potential channel 0.0044 0.0123 0.0122
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0037 0.0098 0.0097
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0023 0.0047 0.0046
Mycobacterium ulcerans monoamine oxidase 0.0025 0.0053 0.0272
Leishmania major heat shock protein 83-1 0.0053 0.0159 0.1041
Schistosoma mansoni transient receptor potential channel 4 0.0066 0.0208 0.0207
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0452 0.1663 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0042 0.0041
Brugia malayi jmjC domain containing protein 0.0017 0.0023 0.0023
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0023 0.0022
Brugia malayi MH2 domain containing protein 0.0181 0.0641 0.0641
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0032 0.0031
Brugia malayi hypothetical protein 0.0017 0.0023 0.0023
Echinococcus multilocularis endoplasmin 0.0047 0.0135 0.0134
Onchocerca volvulus 0.0452 0.1663 0.1662
Trypanosoma cruzi heat shock protein 85, putative 0.0044 0.0125 0.076
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0452 0.1663 0.1663
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0023 0.0047 0.0172
Toxoplasma gondii histone lysine-specific demethylase 0.0025 0.0053 0.0214
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0042 0.0041
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0071 0.0318
Echinococcus multilocularis GPCR, family 2 0.0013 0.0008 0.0007
Schistosoma mansoni sodium/chloride dependent transporter 0.0452 0.1663 0.1662
Trypanosoma brucei heat shock protein, putative 0.0053 0.0159 0.1041
Brugia malayi MH2 domain containing protein 0.0012 0.0005 0.0005
Echinococcus multilocularis lamin 0.0018 0.0027 0.0027
Onchocerca volvulus 0.0163 0.0573 0.0572
Echinococcus multilocularis polycomb protein SCMH1 0.0032 0.0081 0.008
Loa Loa (eye worm) CXXC zinc finger family protein 0.0044 0.0122 0.0121
Echinococcus granulosus neuropeptide s receptor 0.0325 0.1183 0.1182
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0209 0.0208
Echinococcus multilocularis L aminoadipate semialdehyde 0.0057 0.0172 0.0171
Trypanosoma brucei heat shock protein, putative 0.0053 0.0159 0.1041
Echinococcus granulosus mothers against decapentaplegic 5 0.0012 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0045 0.0127 0.0126
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0049 0.0144 0.0143
Brugia malayi steroid hormone receptor 0.0022 0.0042 0.0042
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0023 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.0161 0.0566 0.0565
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0064 0.02 0.0199
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0031 0.0076 0.0075
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0094 0.0312 0.0311
Trypanosoma cruzi heat shock protein 85, putative 0.0053 0.0159 0.1012
Plasmodium falciparum protoporphyrinogen oxidase 0.0025 0.0053 0.0214
Echinococcus multilocularis musashi 0.0018 0.0027 0.0027
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0071 0.1042
Brugia malayi heat shock protein 90 0.0053 0.0159 0.0159
Brugia malayi isocitrate dehydrogenase 0.0023 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0007
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0452 0.1663 0.1663
Onchocerca volvulus Huntingtin homolog 0.0083 0.0273 0.0272
Brugia malayi hypothetical protein 0.0055 0.0164 0.0164
Brugia malayi Pre-SET motif family protein 0.0143 0.0499 0.0499
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0076 0.0075
Loa Loa (eye worm) hypothetical protein 0.0042 0.0115 0.0114
Trypanosoma cruzi heat shock protein 85, putative 0.0053 0.0159 0.1012
Echinococcus multilocularis protein dispatched 1 0.0073 0.0234 0.0233
Schistosoma mansoni heat shock protein 0.0053 0.0159 0.0159
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0042 0.0042
Toxoplasma gondii Hsp90 domain-containing protein 0.0127 0.0439 0.2556
Plasmodium falciparum ataxin-2 like protein, putative 0.0017 0.0023 0.0028
Schistosoma mansoni survival motor neuron protein 0.0033 0.0082 0.0081
Echinococcus multilocularis short transient receptor potential channel 6 0.0044 0.0123 0.0122
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0023 0.0022
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0057 0.0172 0.0172
Echinococcus multilocularis lamin dm0 0.0018 0.0027 0.0027
Toxoplasma gondii hypothetical protein 0.0452 0.1663 1
Schistosoma mansoni transcription factor LCR-F1 0.0055 0.0164 0.0163
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0042 0.0041
Brugia malayi TAR-binding protein 0.0043 0.0121 0.0121
Brugia malayi jmjC domain containing protein 0.0017 0.0023 0.0023
Echinococcus multilocularis protein patched 0.0064 0.02 0.0199
Loa Loa (eye worm) hypothetical protein 0.0025 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0007
Brugia malayi hypothetical protein 0.0452 0.1663 0.1663
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0042 0.0042
Plasmodium vivax heat shock protein, putative 0.0127 0.0439 0.2556
Trypanosoma cruzi transcription factor btf3, putative 0.0024 0.0048 0.0188
Brugia malayi Dopamine receptor protein 2 0.0011 0.0001 0.0001
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0057 0.0252
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.002 0.0032 0.0031
Echinococcus multilocularis neuropeptide s receptor 0.0325 0.1183 0.1182
Trichomonas vaginalis heat shock protein, putative 0.0047 0.0135 0.2009
Echinococcus multilocularis serotonin receptor 0.0135 0.0469 0.0468
Schistosoma mansoni heat shock protein 0.0053 0.0159 0.0159
Echinococcus granulosus endoplasmin 0.0047 0.0135 0.0134
Brugia malayi hypothetical protein 0.0012 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0042 0.0115 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0452 0.1663 0.1662
Leishmania major heat shock protein 83-1 0.0053 0.0159 0.1041
Schistosoma mansoni myelin transcription factor 1 myt1 0.0037 0.0098 0.0097
Giardia lamblia Heat shock protein HSP 90-alpha 0.0044 0.0125 0.7468
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0076 0.0075
Loa Loa (eye worm) hypothetical protein 0.0022 0.0041 0.004
Brugia malayi PHD-finger family protein 0.002 0.0033 0.0033
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0037 0.0098 0.0097
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.002 0.0033 0.0032
Brugia malayi RNA recognition motif domain containing protein 0.0043 0.0121 0.0121
Treponema pallidum sodium- and chloride- dependent transporter 0.2662 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0081 0.008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0013 0.0008 0.0007
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0025 0.0053 0.0214
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0083 0.0273 0.0272
Onchocerca volvulus 0.0022 0.0042 0.0041
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0023 0.0047 0.0046
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0002 0.0002
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0452 0.1663 0.1662
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0076 0.0075
Echinococcus granulosus Niemann Pick C1 protein 0.0213 0.0763 0.0762
Echinococcus granulosus muscleblind protein 0.0346 0.1265 0.1264
Echinococcus multilocularis sodium and chloride dependent glycine 0.0452 0.1663 0.1662
Schistosoma mansoni heat shock protein 0.003 0.0071 0.007
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0002 0.0002
Onchocerca volvulus 0.0032 0.0081 0.008
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0013 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0028 0.0065 0.0065
Entamoeba histolytica hypothetical protein 0.0055 0.0164 0.2896
Loa Loa (eye worm) solute carrier family 6 member 4 0.2662 1 1
Echinococcus multilocularis smad 0.0012 0.0005 0.0004
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0359 0.1311 1
Loa Loa (eye worm) hypothetical protein 0.0135 0.0469 0.0468
Onchocerca volvulus 0.0018 0.0027 0.0027
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0047 0.0135 1
Plasmodium vivax ataxin-2 like protein, putative 0.0017 0.0023 0.0028
Loa Loa (eye worm) hypothetical protein 0.0025 0.0053 0.0053
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0023 0.0047 0.0237
Plasmodium vivax endoplasmin, putative 0.0053 0.0159 0.0858
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0023 0.0047 0.0209
Brugia malayi putative neuropeptide receptor 0.0011 0.0001 0.0001
Echinococcus granulosus lysine specific histone demethylase 1A 0.0025 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.2662 1 1
Plasmodium falciparum endoplasmin, putative 0.0036 0.0095 0.0466
Echinococcus granulosus L aminoadipate semialdehyde 0.0057 0.0172 0.0171
Toxoplasma gondii LsmAD domain-containing protein 0.0017 0.0023 0.0028
Schistosoma mansoni sodium/chloride dependent transporter 0.0452 0.1663 0.1662
Leishmania major heat shock protein 83-1 0.0053 0.0159 0.1041
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0042 0.0042
Brugia malayi follicle stimulating hormone receptor 0.0011 0.0001 0.0001
Entamoeba histolytica heat shock protein 90, putative 0.0053 0.0159 0.2808
Loa Loa (eye worm) MBCTL1 0.0037 0.0098 0.0097
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0452 0.1663 0.1662
Brugia malayi jmjC domain containing protein 0.0067 0.0209 0.0209
Brugia malayi Bromodomain containing protein 0.002 0.0033 0.0033
Leishmania major heat shock protein 83-1 0.0053 0.0159 0.1041
Brugia malayi Smad1 0.0012 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0042 0.0042
Schistosoma mansoni sodium-dependent amino acid transporter 0.0452 0.1663 0.1662
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0128 0.0441 0.044
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0023 0.0022
Brugia malayi Dopamine receptor 0.0011 0.0001 0.0001
Trypanosoma cruzi PAB1-binding protein , putative 0.0017 0.0023 0.0002
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0055 0.0164 0.2896
Brugia malayi jmjC domain containing protein 0.0105 0.0355 0.0355
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0037 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0192 0.0682 0.0681
Echinococcus multilocularis mothers against decapentaplegic 5 0.0012 0.0005 0.0004
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0151 0.0526 0.0525
Loa Loa (eye worm) histone methyltransferase 0.0015 0.0015 0.0014
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0023 0.0047 0.0046
Trypanosoma cruzi heat shock protein 85, putative 0.0053 0.0159 0.1012
Leishmania major heat shock protein 83-1 0.0053 0.0159 0.1041
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0452 0.1663 0.1662
Treponema pallidum heat shock protein 90 0.0047 0.0135 0.0117
Schistosoma mansoni hypothetical protein 0.0198 0.0703 0.0703
Leishmania major hypothetical protein, conserved 0.0017 0.0023 0.0032
Onchocerca volvulus 0.0452 0.1663 0.1662
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0042 0.0041
Trichomonas vaginalis heat shock protein, putative 0.0047 0.0135 0.2009
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0071 0.007
Loa Loa (eye worm) hypothetical protein 0.0135 0.0469 0.0468
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0053 0.0214
Echinococcus multilocularis cpg binding protein 0.0046 0.0132 0.0131
Schistosoma mansoni endoplasmin 0.0053 0.0159 0.0159
Onchocerca volvulus 0.0033 0.0082 0.0081
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0041
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0042 0.0041
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0061 0.0259
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0018 0.0025 0.005
Giardia lamblia PHD finger protein 15 0.002 0.0033 0.0595
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0002 0.0002
Toxoplasma gondii heat shock protein HSP90 0.0053 0.0159 0.0858
Brugia malayi Endoplasmin precursor 0.0053 0.0159 0.0159
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0452 0.1663 0.1662
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Echinococcus granulosus intermediate filament protein 0.0018 0.0027 0.0027
Onchocerca volvulus 0.0044 0.0122 0.0121
Schistosoma mansoni hypothetical protein 0.0062 0.0191 0.019
Leishmania major heat shock protein 83-1 0.0053 0.0159 0.1041
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0023 0.0022
Entamoeba histolytica hypothetical protein 0.0024 0.0048 0.0592
Echinococcus granulosus SAM and MBT domain containing protein 0.0032 0.0081 0.008
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0042 0.0041
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0015 0.0014
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0452 0.1663 0.1662
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0041
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0025 0.0053 0.0214
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0042 0.0115 0.0114
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0002 0.0002
Trypanosoma brucei heat shock protein, putative 0.0053 0.0159 0.1041
Plasmodium vivax heat shock protein 86, putative 0.0053 0.0159 0.0858
Onchocerca volvulus Alhambra homolog 0.002 0.0033 0.0032
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0029 0.0067 0.0362
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0023 0.0047 0.0046
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0005 0.0004
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0018 0.0025 0.005
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0143 0.0499 0.0499
Echinococcus granulosus transient receptor potential gamma protein 0.0066 0.0208 0.0207
Echinococcus granulosus sodium and chloride dependent glycine 0.0452 0.1663 0.1662
Plasmodium vivax heat shock protein 90, putative 0.003 0.0071 0.0318
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0375 0.1375 0.1375
Brugia malayi nuclear receptor NHR-88 0.0022 0.0042 0.0042
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0042 0.0041
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0105 0.0355 0.0354
Schistosoma mansoni hypothetical protein 0.0033 0.0082 0.0081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0041 0.004
Trypanosoma brucei heat shock protein 90, putative 0.0053 0.0159 0.1041
Loa Loa (eye worm) hypothetical protein 0.0064 0.02 0.0199
Echinococcus multilocularis protoporphyrinogen oxidase 0.0025 0.0053 0.0053
Leishmania major heat shock protein 83-1 0.0053 0.0159 0.1041
Loa Loa (eye worm) hypothetical protein 0.0452 0.1663 0.1662
Brugia malayi intermediate filament protein 0.0018 0.0027 0.0027
Schistosoma mansoni endoplasmin 0.0053 0.0159 0.0159
Brugia malayi Ets-domain containing protein 0.0049 0.0144 0.0144
Giardia lamblia Grp94/Hsp90 0.0047 0.0135 0.8195
Plasmodium falciparum phd finger protein, putative 0.002 0.0033 0.009
Brugia malayi MH1 domain containing protein 0.0012 0.0005 0.0005
Echinococcus granulosus transient receptor potential ion channel A 0.0064 0.0199 0.0198
Loa Loa (eye worm) hypothetical protein 0.0083 0.0273 0.0272
Echinococcus multilocularis transcription factor btf3 0.0024 0.0048 0.0047
Echinococcus granulosus TGF beta signal transducer SmadC 0.0012 0.0005 0.0004
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0359 0.1311 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0206 0.0734 0.5264
Trichomonas vaginalis endoplasmin, putative 0.0036 0.0095 0.1273
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0042 0.0042
Brugia malayi neuropeptide F receptor 0.0011 0.0001 0.0001
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0042 0.0041
Echinococcus granulosus sterol regulatory element binding protein 0.0064 0.02 0.0199
Echinococcus multilocularis survival motor neuron protein 1 0.0161 0.0566 0.0565
Echinococcus multilocularis microtubule associated protein 2 0.047 0.1732 0.1731
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0011 0.0001 0.0001
Echinococcus granulosus neuropeptide receptor A26 0.0325 0.1183 0.1182
Brugia malayi nuclear receptor RXR 0.0012 0.0002 0.0002
Echinococcus granulosus peregrin 0.0026 0.0058 0.0057
Toxoplasma gondii isocitrate dehydrogenase 0.0023 0.0047 0.0172
Echinococcus granulosus Niemann Pick C1 protein 0.0149 0.0521 0.052
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.005
Trypanosoma cruzi heat shock protein, putative 0.003 0.0071 0.0355
Schistosoma mansoni amine oxidase 0.0025 0.0053 0.0053
Brugia malayi SWIRM domain containing protein 0.0025 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0022
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0452 0.1663 0.1662
Loa Loa (eye worm) MH2 domain-containing protein 0.0181 0.0641 0.064
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0031 0.0076 0.0076
Echinococcus multilocularis transient receptor potential gamma protein 0.0066 0.0208 0.0207
Schistosoma mansoni hypothetical protein 0.0279 0.1009 0.1008
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0043 0.0121 0.012
Loa Loa (eye worm) hypothetical protein 0.0025 0.0053 0.0053
Trypanosoma brucei Heat shock protein 83, putative 0.0053 0.0159 0.1041
Loa Loa (eye worm) nuclear hormone receptor 0.0072 0.0229 0.0228
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0042 0.0041
Schistosoma mansoni hypothetical protein 0.0115 0.0394 0.0393
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0011 0.0001 0.0001
Echinococcus granulosus dnaJ subfamily B 0.0279 0.1009 0.1008
Echinococcus multilocularis muscleblind protein 0.0346 0.1265 0.1264
Brugia malayi Transient-receptor-potential like protein 0.0025 0.0051 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0043 0.0121 0.012
Toxoplasma gondii isocitrate dehydrogenase 0.0023 0.0047 0.0172
Leishmania major heat shock protein 83-1 0.0053 0.0159 0.1041
Loa Loa (eye worm) hypothetical protein 0.0375 0.1375 0.1374
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0042 0.0041
Echinococcus multilocularis flap endonuclease 1 0.0018 0.0025 0.0024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0031 0.0076 0.0075
Loa Loa (eye worm) fli-1 protein 0.015 0.0523 0.0522
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0083 0.0273 0.0272
Onchocerca volvulus 0.0448 0.165 0.1649
Loa Loa (eye worm) ICD-1 protein 0.0024 0.0048 0.0047
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0033 0.0082 0.0082
Echinococcus multilocularis PHD finger protein rhinoceros 0.002 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0041
Brugia malayi hypothetical protein 0.0012 0.0002 0.0002
Echinococcus granulosus phd:f box containing protein 0.0017 0.0023 0.0022
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0071 0.007
Echinococcus multilocularis Smad4 0.0012 0.0005 0.0004
Entamoeba histolytica Flap nuclease, putative 0.0018 0.0025 0.0136
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0097 0.0325 0.224
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0113 0.0112
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0041
Mycobacterium tuberculosis Conserved hypothetical protein 0.0108 0.0367 0.2912
Echinococcus multilocularis Niemann Pick C1 protein 0.0149 0.0521 0.052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0042 0.0041
Brugia malayi amine oxidase, flavin-containing family protein 0.0025 0.0053 0.0053
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0042 0.0041
Brugia malayi mbt repeat family protein 0.0032 0.0081 0.0081
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0042 0.0041
Schistosoma mansoni hypothetical protein 0.0062 0.0191 0.019
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0071 0.007
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0023 0.0022
Schistosoma mansoni Smad4 0.0012 0.0005 0.0004
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0042 0.0041
Brugia malayi latrophilin 2 splice variant baaae 0.0028 0.0065 0.0065
Plasmodium falciparum ataxin-2 like protein, putative 0.0017 0.0023 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0042 0.0041
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0007
Loa Loa (eye worm) heat shock protein 75 0.003 0.0071 0.007
Trypanosoma brucei transcription factor BTF3, putative 0.0024 0.0048 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.02 0.3185
Entamoeba histolytica transcription factor BTF3, putative 0.0024 0.0048 0.0592
Schistosoma mansoni cpg binding protein 0.0046 0.0132 0.0131
Leishmania major heat shock protein 83-1 0.0053 0.0159 0.1041
Loa Loa (eye worm) intermediate filament protein 0.0018 0.0027 0.0027
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0042 0.0041
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0042 0.0041
Plasmodium vivax SET domain protein, putative 0.0022 0.0041 0.014
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0022 0.0041 0.004
Schistosoma mansoni flap endonuclease-1 0.0016 0.0019 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0042 0.0041
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Echinococcus granulosus heat shock protein 90 0.0044 0.0125 0.0125
Echinococcus multilocularis dnaJ subfamily B 0.0279 0.1009 0.1008
Trypanosoma cruzi UDP-galactopyranose mutase 0.0025 0.0053 0.0228
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0012 0.0005 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0048 0.0418
Trypanosoma brucei heat shock protein, putative 0.0053 0.0159 0.1041
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0452 0.1663 0.1662
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0041
Schistosoma mansoni tar DNA-binding protein 0.0043 0.0121 0.012
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0042 0.0041
Echinococcus granulosus short transient receptor potential channel 6 0.0044 0.0123 0.0122
Onchocerca volvulus 0.0018 0.0027 0.0027
Plasmodium vivax amine transporter, putative 0.0452 0.1663 1
Echinococcus granulosus jumonji domain containing protein 0.0028 0.0062 0.0062
Schistosoma mansoni transcription factor btf3 0.0024 0.0048 0.0047
Onchocerca volvulus 0.0057 0.0172 0.0171
Leishmania major heat shock protein 83-1 0.0053 0.0159 0.1041
Schistosoma mansoni gabp alpha 0.0049 0.0144 0.0143
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0023 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.02 0.0199
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0025 0.0053 0.0053
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0023 0.0047 0.0209
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0452 0.1663 1
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0452 0.1663 0.1662
Echinococcus granulosus heat shock protein 90 0.0053 0.0159 0.0159
Echinococcus multilocularis isocitrate dehydrogenase 0.0023 0.0047 0.0046
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0032 0.0031
Plasmodium falciparum basic transcription factor 3b, putative 0.0024 0.0048 0.0181
Echinococcus multilocularis jumonji domain containing protein 0.0028 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0048 0.0418
Schistosoma mansoni smad1 5 8 and 0.0012 0.0005 0.0004
Onchocerca volvulus 0.0022 0.0041 0.004
Brugia malayi hypothetical protein 0.0448 0.165 0.165
Schistosoma mansoni SET domain protein 0.0024 0.0049 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0042 0.0042
Leishmania major heat shock protein 83-1 0.0053 0.0159 0.1041
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0023 0.0027
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0042 0.0041
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0023 0.0047 0.0209
Plasmodium falciparum flap endonuclease 1 0.0018 0.0025 0.0042
Loa Loa (eye worm) MH2 domain-containing protein 0.0012 0.0005 0.0004
Brugia malayi mbt repeat family protein 0.0032 0.0081 0.0081
Echinococcus granulosus cpg binding protein 0.0046 0.0132 0.0131
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0128 0.0441 0.044
Schistosoma mansoni hypothetical protein 0.0055 0.0164 0.0163
Brugia malayi RE15519p 0.0011 0.0001 0.0001
Schistosoma mansoni ets-related 0.015 0.0523 0.0522
Loa Loa (eye worm) RNA binding protein 0.0043 0.0121 0.012
Echinococcus granulosus heat shock protein 0.0053 0.0159 0.0159
Echinococcus multilocularis heat shock protein 90 0.0044 0.0125 0.0125
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.188 0.705 0.705
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0022 0.0041 0.014
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0149 0.0521 1
Plasmodium vivax hypothetical protein, conserved 0.002 0.0033 0.009
Schistosoma mansoni lamin 0.0018 0.0027 0.0027
Brugia malayi hypothetical protein 0.0083 0.0273 0.0273
Echinococcus multilocularis expressed conserved protein 0.014 0.0487 0.0486
Brugia malayi ecdysteroid receptor 0.0022 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0151 0.0526 0.0525
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0042 0.0042
Echinococcus granulosus serotonin transporter 0.2662 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0209 0.0208
Trypanosoma cruzi heat shock protein 90, putative 0.0053 0.0159 0.1012
Brugia malayi Pre-SET motif family protein 0.0022 0.0041 0.0041
Trypanosoma brucei heat shock protein, putative 0.0053 0.0159 0.1041
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0044 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0037 0.0098 0.0097
Echinococcus granulosus survival motor neuron protein 1 0.0161 0.0566 0.0565
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0028 0.0063 0.0275
Plasmodium vivax flap endonuclease 1, putative 0.0018 0.0025 0.0042
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0035 0.0091 0.0507
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0151 0.053 0.0529
Loa Loa (eye worm) serotonin transporter b 0.2662 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0042 0.0041
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0452 0.1663 0.1662
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.0025 0.0053 0.0053
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0011 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0028 0.0065 0.0065
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0011 0.0001 0.0001
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0061 0.0652
Schistosoma mansoni smad1 5 8 and 0.0012 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0452 0.1663 0.1662
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0025 0.0051 0.005
Echinococcus granulosus short transient receptor potential channel 6 0.0044 0.0123 0.0122
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0042 0.0041
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0018 0.0025 0.0042
Brugia malayi larval opioid receptor 0.0011 0.0001 0.0001
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0023 0.0022
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0022 0.0041 0.004
Leishmania major heat shock protein, putative 0.003 0.0071 0.0386
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0042 0.0042
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0031 0.0076 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0048 0.0418
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0002 0.0002
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0023 0.0022
Echinococcus multilocularis SAM and MBT domain containing protein 0.0032 0.0081 0.008
Schistosoma mansoni hypothetical protein 0.0062 0.0191 0.019
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0042 0.0041
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0025 0.0053 0.3008
Schistosoma mansoni sex comb on midleg homolog 0.0032 0.0081 0.008
Loa Loa (eye worm) Smad1 0.0012 0.0005 0.0004
Onchocerca volvulus 0.0452 0.1663 0.1662
Trypanosoma cruzi heat shock protein 90, putative 0.0044 0.0125 0.076
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.0053 0.0294
Loa Loa (eye worm) hypothetical protein 0.0022 0.0042 0.0041
Loa Loa (eye worm) mbt repeat family protein 0.0032 0.0081 0.008
Echinococcus multilocularis transient receptor potential ion channel A 0.0064 0.0199 0.0198
Mycobacterium ulcerans oxidoreductase 0.0025 0.0053 0.0272
Toxoplasma gondii hypothetical protein 0.0033 0.0083 0.0396
Loa Loa (eye worm) hypothetical protein 0.2662 1 1
Schistosoma mansoni patched 1 0.0064 0.02 0.0199
Echinococcus granulosus transcription factor btf3 0.0024 0.0048 0.0047
Loa Loa (eye worm) norepinephrine transporter 0.2662 1 1
Leishmania major C-8 sterol isomerase-like protein 0.0375 0.1375 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0097 0.0325 0.2265
Echinococcus multilocularis Niemann Pick C1 protein 0.0213 0.0763 0.0762
Brugia malayi hypothetical protein 0.0025 0.0053 0.0053
Brugia malayi MH1 domain containing protein 0.0012 0.0005 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0031 0.0076 0.0075
Loa Loa (eye worm) hypothetical protein 0.0073 0.0233 0.0233
Leishmania major basic transcription factor 3a, putative 0.0024 0.0048 0.0219
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0452 0.1663 0.1662
Echinococcus multilocularis tar DNA binding protein 0.0043 0.0121 0.012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Trypanosoma cruzi UDP-galactopyranose mutase 0.0025 0.0053 0.0228
Brugia malayi Niemann-Pick C1 protein precursor 0.0149 0.0521 0.0521
Brugia malayi Serotonin receptor 0.0011 0.0001 0.0001
Onchocerca volvulus 0.2662 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0042 0.0041
Brugia malayi Muscleblind-like protein 0.0346 0.1265 0.1265
Echinococcus granulosus smad 0.0012 0.0005 0.0004
Schistosoma mansoni sodium/chloride dependent transporter 0.2662 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0042 0.0042
Trypanosoma cruzi PAB1-binding protein , putative 0.0017 0.0023 0.0002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0053 0.0053
Toxoplasma gondii heat shock protein 90, putative 0.0053 0.0159 0.0858
Mycobacterium ulcerans dehydrogenase 0.0025 0.0053 0.0272
Brugia malayi Steroid receptor seven-up type 2 0.0083 0.0273 0.0273

Activities

Activity type Activity value Assay description Source Reference
A-selectivity (binding) > 286 Selectivity for rat Monoamine oxidase A as ratio of Ki(MAO-B)/Ki(MAO-A) ChEMBL. 15974574
Ki (binding) = 0.35 uM Inhibtory concentration for rat Monoamine oxidase A ChEMBL. 15974574
Ki (binding) = 0.35 uM Inhibtory concentration for rat Monoamine oxidase A ChEMBL. 15974574
Ki (binding) > 100 uM Inhibitory concentration for human Monoamine oxidase B ChEMBL. 15974574
Ki (binding) > 100 uM Inhibitory concentration for human Monoamine oxidase B ChEMBL. 15974574

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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