Detailed information for compound 35951

Basic information

Technical information
  • TDR Targets ID: 35951
  • Name: [(Z)-4-[(2-amino-6-oxo-3H-purin-9-yl)oxy]but- 1-enyl]phosphonic acid
  • MW: 301.196 | Formula: C9H12N5O5P
  • H donors: 4 H acceptors: 7 LogP: -1.12 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc(O)c2c(n1)n(OCC/C=C\P(=O)(O)O)cn2
  • InChi: 1S/C9H12N5O5P/c10-9-12-7-6(8(15)13-9)11-5-14(7)19-3-1-2-4-20(16,17)18/h2,4-5H,1,3H2,(H2,16,17,18)(H3,10,12,13,15)/b4-2-
  • InChiKey: ACEIHNQZRUVVEZ-RQOWECAXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(Z)-4-[(2-azanyl-6-oxo-3H-purin-9-yl)oxy]but-1-enyl]phosphonic acid
  • [(Z)-4-[(2-amino-6-keto-3H-purin-9-yl)oxy]but-1-enyl]phosphonic acid
  • AIDS-028624
  • AIDS028624
  • (Z)-9-[(4-Phosphonobut-3-enyl)oxy]guanine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0017 0.0054 0.0247
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0054 1
Schistosoma mansoni hypothetical protein 0.0017 0.0054 0.0052
Echinococcus multilocularis UNCoordinated family member (unc 13) 0.0017 0.0054 0.0247
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0017 0.0054 0.0247
Toxoplasma gondii Elicitor-responsive protein, putative 0.0017 0.0054 0.0163
Leishmania major hypothetical protein, conserved 0.0017 0.0054 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Entamoeba histolytica hypothetical protein 0.0017 0.0054 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Trichomonas vaginalis synaptotagmin, putative 0.0017 0.0054 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Echinococcus granulosus protein kinase c epsilon type 0.0017 0.0054 0.0247
Leishmania major hypothetical protein, conserved 0.0017 0.0054 1
Brugia malayi C2 domain containing protein 0.0017 0.0054 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0017 0.0054 0.0052
Loa Loa (eye worm) C2 domain-containing protein 0.0017 0.0054 0.017
Plasmodium falciparum ferlin, putative 0.0017 0.0054 0.5
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0017 0.0054 0.0247
Schistosoma mansoni hypothetical protein 0.0017 0.0054 0.0052
Trichomonas vaginalis synaptotagmin, putative 0.0017 0.0054 0.5
Echinococcus multilocularis extended synaptotagmin 2 0.0017 0.0054 0.0247
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0054 1
Giardia lamblia ABC transporter, putative 0.0014 0.0002 1
Schistosoma mansoni synaptotagmin 0.0017 0.0054 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0017 0.0054 0.0247
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0054 1
Echinococcus multilocularis serine threonine protein kinase 0.0017 0.0054 0.0247
Schistosoma mansoni unc-13 (munc13) 0.0017 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Plasmodium vivax ferlin, putative 0.0017 0.0054 0.5
Echinococcus granulosus UNCoordinated family member unc 13 0.0017 0.0054 0.0247
Trichomonas vaginalis synaptotagmin, putative 0.0017 0.0054 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Echinococcus multilocularis myoferlin 0.0017 0.0054 0.0247
Echinococcus granulosus synaptotagmin 2 0.0017 0.0054 0.0247
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0054 1
Trichomonas vaginalis copine, putative 0.0017 0.0054 0.5
Loa Loa (eye worm) C2 domain-containing protein 0.0017 0.0054 0.017
Schistosoma mansoni synaptic ras gtpase activating protein syngap 0.0017 0.0054 0.0052
Echinococcus granulosus Protein kinase C brain isozyme 0.0017 0.0054 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Echinococcus multilocularis synaptotagmin 2 0.0017 0.0054 0.0247
Schistosoma mansoni otoferlin 0.0017 0.0054 0.0052
Trichomonas vaginalis calcium-dependent lipid-binding protein, putative 0.0017 0.0054 0.5
Echinococcus multilocularis intersectin 2 0.0017 0.0054 0.0247
Echinococcus multilocularis copine 9 0.0017 0.0054 0.0247
Leishmania major copine i-like protein 0.0017 0.0054 1
Brugia malayi Copine family protein 0.0017 0.0054 1
Entamoeba histolytica C2 domain containing protein 0.0017 0.0054 1
Trypanosoma brucei C2 domain containing protein, putative 0.0017 0.0054 1
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0017 0.0054 0.5
Brugia malayi Synaptotagmin protein 3 0.0017 0.0054 1
Leishmania major hypothetical protein, conserved 0.0017 0.0054 1
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0126 0.2096 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0017 0.0054 0.5
Entamoeba histolytica hypothetical protein 0.0017 0.0054 1
Schistosoma mansoni synaptotagmin 0.0017 0.0054 0.0052
Leishmania major c2 domain protein, putative 0.0017 0.0054 1
Trichomonas vaginalis copine, putative 0.0017 0.0054 0.5
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0017 0.0054 1
Loa Loa (eye worm) synaptotagmin-1 0.0017 0.0054 0.017
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0017 0.0054 0.0247
Echinococcus multilocularis active breakpoint cluster region 0.0017 0.0054 0.0247
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0054 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Giardia lamblia MRP-like ABC transporter 0.0014 0.0002 1
Trypanosoma brucei predicted C2 domain protein 0.0017 0.0054 1
Trypanosoma cruzi synaptotagmin, putative 0.0017 0.0054 1
Toxoplasma gondii MAPEG family protein 0.0126 0.2096 0.6619
Entamoeba histolytica protein kinase, putative 0.0017 0.0054 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0017 0.0054 0.5
Entamoeba histolytica C2 domain containing protein 0.0017 0.0054 1
Echinococcus multilocularis copine 9 0.0017 0.0054 0.0247
Entamoeba histolytica C2 domain containing protein 0.0017 0.0054 1
Brugia malayi LD23056p 0.0017 0.0054 1
Echinococcus granulosus active breakpoint cluster region 0.0017 0.0054 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Trypanosoma brucei predicted C2 domain protein 0.0017 0.0054 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Trichomonas vaginalis synaptotagmin, putative 0.0017 0.0054 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Schistosoma mansoni unc-13 (munc13) 0.0017 0.0054 0.0052
Trichomonas vaginalis copine, putative 0.0017 0.0054 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0017 0.0054 0.017
Leishmania major hypothetical protein, conserved 0.0017 0.0054 1
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0017 0.0054 0.0247
Entamoeba histolytica DENN domain protein 0.0017 0.0054 1
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0017 0.0054 0.5
Brugia malayi C2 domain containing protein 0.0017 0.0054 1
Schistosoma mansoni mctp-related 0.0017 0.0054 0.0052
Leishmania major hypothetical protein, conserved 0.0017 0.0054 1
Echinococcus multilocularis synaptotagmin 0.0017 0.0054 0.0247
Brugia malayi C2 domain containing protein 0.0017 0.0054 1
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0017 0.0054 0.0247
Trypanosoma brucei C2 domain containing protein, putative 0.0017 0.0054 1
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0017 0.0054 0.5
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0017 0.0054 0.0247
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0017 0.0054 0.0247
Echinococcus granulosus synaptotagmin 15 0.0017 0.0054 0.0247
Trypanosoma brucei C2 domain containing protein, putative 0.0017 0.0054 1
Schistosoma mansoni rabphilin-3a 0.0017 0.0054 0.0052
Entamoeba histolytica C2 domain containing protein 0.0017 0.0054 1
Echinococcus granulosus copine 9 0.0017 0.0054 0.0247
Echinococcus granulosus microsomal glutathione S transferase 3 0.0126 0.2096 1
Loa Loa (eye worm) hypothetical protein 0.0184 0.3166 1
Entamoeba histolytica hypothetical protein 0.0017 0.0054 1
Echinococcus granulosus neural cell expressed developmentally 0.0017 0.0054 0.0247
Loa Loa (eye worm) hypothetical protein 0.0184 0.3166 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Brugia malayi C2 domain containing protein 0.0017 0.0054 1
Schistosoma mansoni unc-13 (munc13) 0.0017 0.0054 0.0052
Schistosoma mansoni fer-1-related 0.0017 0.0054 0.0052
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0017 0.0054 0.017
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0017 0.0054 1
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0017 0.0054 0.0247
Entamoeba histolytica calcium-binding protein, putative 0.0017 0.0054 1
Schistosoma mansoni microsomal glutathione s-transferase 0.0126 0.2096 0.2094
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0054 1
Loa Loa (eye worm) hypothetical protein 0.0184 0.3166 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Entamoeba histolytica C2 domain protein, putative 0.0017 0.0054 1
Onchocerca volvulus Putative cc2d1b protein 0.0017 0.0054 0.5
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0184 0.3166 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0007
Loa Loa (eye worm) C2 domain-containing protein 0.0017 0.0054 0.017
Trichomonas vaginalis annexin VII, putative 0.0017 0.0054 0.5
Echinococcus granulosus copine 9 0.0017 0.0054 0.0247
Trichomonas vaginalis Circumsporozoite protein precursor, putative 0.0017 0.0054 0.5
Echinococcus multilocularis synaptotagmin 0.0017 0.0054 0.0247
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Leishmania major hypothetical protein, conserved 0.0017 0.0054 1
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0017 0.0054 1
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0054 0.0052
Echinococcus granulosus myoferlin 0.0017 0.0054 0.0247
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Trypanosoma cruzi cAMP binding protein, putative 0.0017 0.0054 1
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0054 0.5
Brugia malayi protein kinase C II. 0.0017 0.0054 1
Echinococcus granulosus extended synaptotagmin 2 0.0017 0.0054 0.0247
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0054 1
Schistosoma mansoni synaptotagmin 0.0017 0.0054 0.0052
Brugia malayi C2 domain containing protein 0.0017 0.0054 1
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0017 0.0054 0.0247
Echinococcus multilocularis synaptotagmin protein 4 0.0017 0.0054 0.0247
Schistosoma mansoni glut4 vesicle protein-related 0.0017 0.0054 0.0052
Schistosoma mansoni copine 0.0017 0.0054 0.0052
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0017 0.0054 0.0052
Plasmodium falciparum double C2-like domain-containing protein 0.0017 0.0054 0.5
Echinococcus granulosus Immunoglobulin E set 0.0017 0.0054 0.0247
Echinococcus granulosus synaptotagmin 0.0017 0.0054 0.0247
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0017 0.0054 0.0247
Onchocerca volvulus 0.0017 0.0054 0.5
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.0002 1
Echinococcus granulosus synaptotagmin 0.0017 0.0054 0.0247
Brugia malayi C2 domain containing protein 0.0017 0.0054 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Toxoplasma gondii hypothetical protein 0.0017 0.0054 0.0163
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Trichomonas vaginalis synaptotagmin, putative 0.0017 0.0054 0.5
Brugia malayi C2 domain containing protein 0.0017 0.0054 1
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0054 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Echinococcus granulosus synaptotagmin 0.0017 0.0054 0.0247
Trypanosoma cruzi C2 domain/Ankyrin repeats (3 copies), putative 0.0017 0.0054 1
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0017 0.0054 0.017
Onchocerca volvulus 0.0017 0.0054 0.5
Brugia malayi Synapse defective protein 1 0.0017 0.0054 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Echinococcus multilocularis synaptotagmin 0.0017 0.0054 0.0247
Schistosoma mansoni synaptotagmin 12 0.0017 0.0054 0.0052
Echinococcus multilocularis neural cell expressed, developmentally 0.0017 0.0054 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Onchocerca volvulus Multiple C2 domain and transmembrane region protein homolog 0.0017 0.0054 0.5
Schistosoma mansoni synaptotagmin 0.0017 0.0054 0.0052
Onchocerca volvulus 0.0017 0.0054 0.5
Toxoplasma gondii hypothetical protein 0.0017 0.0054 0.0163
Brugia malayi Synaptotagmin I 0.0017 0.0054 1
Brugia malayi C2 domain containing protein 0.0017 0.0054 1
Brugia malayi Copine VIII 0.0017 0.0054 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0017 0.0054 0.0052
Entamoeba histolytica C2 domain containing protein 0.0017 0.0054 1
Trypanosoma brucei predicted C2 domain protein 0.0017 0.0054 1
Echinococcus granulosus NEDD4 E3 ubiquitin protein ligase WWP1 0.0017 0.0054 0.0247
Schistosoma mansoni synaptotagmin 12 0.0017 0.0054 0.0052
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0017 0.0054 0.0247
Trichomonas vaginalis copine, putative 0.0017 0.0054 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0054 1
Echinococcus multilocularis protein piccolo 0.0017 0.0054 0.0247
Schistosoma mansoni hypothetical protein 0.0017 0.0054 0.0052
Onchocerca volvulus 0.0017 0.0054 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Entamoeba histolytica C2 domain containing protein 0.0017 0.0054 1
Toxoplasma gondii C2 domain-containing protein 0.0017 0.0054 0.0163
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.0017 0.0054 0.0052
Schistosoma mansoni synaptotagmin 0.0017 0.0054 0.0052
Brugia malayi calpain 5 0.0017 0.0054 1
Toxoplasma gondii hypothetical protein 0.0017 0.0054 0.0163
Trichomonas vaginalis vab10 spectraplakin, putative 0.0017 0.0054 0.5
Brugia malayi C2 domain containing protein 0.0017 0.0054 1
Echinococcus granulosus protein kinase C gamma type 0.0017 0.0054 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Entamoeba histolytica C2 domain containing protein 0.0017 0.0054 1
Onchocerca volvulus 0.0017 0.0054 0.5
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0017 0.0054 0.5
Brugia malayi C2 domain containing protein 0.0017 0.0054 1
Brugia malayi NEDD4.2 0.0017 0.0054 1
Schistosoma mansoni protein kinase C 0.0017 0.0054 0.0052
Onchocerca volvulus 0.0017 0.0054 0.5
Entamoeba histolytica protein kinase, putative 0.0017 0.0054 1
Echinococcus granulosus synaptotagmin protein 4 0.0017 0.0054 0.0247
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0054 0.0052
Brugia malayi C2 domain containing protein 0.0017 0.0054 1
Loa Loa (eye worm) Nedd4-PD 0.0017 0.0054 0.017
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.0002 1
Plasmodium falciparum ferlin, putative 0.0017 0.0054 0.5
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0017 0.0054 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Echinococcus multilocularis unc 13 (munc13) 0.0017 0.0054 0.0247
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Trichomonas vaginalis Proline-rich protein, putative 0.0017 0.0054 0.5
Toxoplasma gondii ferlin family protein 0.0017 0.0054 0.0163
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Echinococcus multilocularis NEDD4 E3 ubiquitin protein ligase WWP1 0.0017 0.0054 0.0247
Trypanosoma cruzi Coiled-coil and C2 domain-containing protein 0.0017 0.0054 1
Echinococcus multilocularis calpain 5 0.0017 0.0054 0.0247
Echinococcus granulosus synaptotagmin 0.0017 0.0054 0.0247
Brugia malayi C2 domain containing protein 0.0017 0.0054 1
Entamoeba histolytica hypothetical protein, conserved 0.0017 0.0054 1
Plasmodium vivax ferlin, putative 0.0017 0.0054 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0017 0.0054 0.5
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0017 0.0054 1
Trypanosoma brucei cAMP binding protein, putative 0.0017 0.0054 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Echinococcus granulosus intersectin 2 0.0017 0.0054 0.0247
Echinococcus granulosus calpain 5 0.0017 0.0054 0.0247
Brugia malayi phospholipase C homolog 0.0017 0.0054 1
Loa Loa (eye worm) copine family protein 0.0017 0.0054 0.017
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Leishmania major hypothetical protein, conserved 0.0017 0.0054 1
Trichomonas vaginalis copine, putative 0.0017 0.0054 0.5
Schistosoma mansoni synaptotagmin 0.0017 0.0054 0.0052
Entamoeba histolytica hypothetical protein, conserved 0.0017 0.0054 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Trypanosoma cruzi C2 domain containing protein, putative 0.0017 0.0054 1
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0017 0.0054 0.0247
Trypanosoma brucei synaptotagmin, putative 0.0017 0.0054 1
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0017 0.0054 0.0247
Trichomonas vaginalis ion channel nompc, putative 0.0017 0.0054 0.5
Schistosoma mansoni E3 ubiquitin-protein ligase nedd-4 0.0017 0.0054 0.0052
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0017 0.0054 0.0247
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0017 0.0054 0.017
Toxoplasma gondii hypothetical protein 0.0184 0.3166 1
Onchocerca volvulus 0.0017 0.0054 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Onchocerca volvulus 0.0017 0.0054 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0054 1
Schistosoma mansoni Mername-AA248 (C02 family) 0.0017 0.0054 0.0052
Trichomonas vaginalis synaptotagmin, putative 0.0017 0.0054 0.5
Plasmodium vivax double C2-like domain-containing protein, putative 0.0017 0.0054 0.5
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0017 0.0054 0.0052
Schistosoma mansoni nedd-4-like E3 ubiquitin-protein ligase 0.0017 0.0054 0.0052
Trypanosoma brucei C2 domain containing protein, putative 0.0017 0.0054 1
Brugia malayi Variant SH3 domain containing protein 0.0017 0.0054 1
Leishmania major hypothetical protein, conserved 0.0017 0.0054 1
Loa Loa (eye worm) C2 domain-containing protein 0.0017 0.0054 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Trypanosoma cruzi synaptotagmin, putative 0.0017 0.0054 1
Trichomonas vaginalis splicing factor 3A subunit, putative 0.0017 0.0054 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0054 1
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0017 0.0054 0.0247
Loa Loa (eye worm) C2 domain-containing protein 0.0017 0.0054 0.017
Echinococcus granulosus synaptotagmin 0.0017 0.0054 0.0247
Echinococcus multilocularis synaptotagmin 15 0.0017 0.0054 0.0247
Echinococcus multilocularis 0.0017 0.0054 0.0247
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Schistosoma mansoni rho gtpase activating protein 0.0017 0.0054 0.0052
Leishmania major phospholipase c-like protein 0.0017 0.0054 1
Brugia malayi Synapse defective protein 1 0.0017 0.0054 1
Schistosoma mansoni hypothetical protein 0.0017 0.0054 0.0052
Trypanosoma brucei C2 domain/Ankyrin repeats (3 copies), putative 0.0017 0.0054 1
Entamoeba histolytica C2 domain containing protein 0.0017 0.0054 1
Echinococcus granulosus otoferlin 0.0017 0.0054 0.0247
Schistosoma mansoni synaptotagmin-like protein 0.0017 0.0054 0.0052
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0017 0.0054 0.0247
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0017 0.0054 0.0163
Echinococcus multilocularis protein kinase c epsilon type 0.0017 0.0054 0.0247
Entamoeba histolytica C2 domain containing protein 0.0017 0.0054 1
Echinococcus multilocularis synaptotagmin 0.0017 0.0054 0.0247
Echinococcus granulosus unc 13 munc13 0.0017 0.0054 0.0247
Entamoeba histolytica Rap/Ran GTPase activating protein, putative 0.0017 0.0054 1
Brugia malayi WW domain containing protein 0.0017 0.0054 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Entamoeba histolytica hypothetical protein 0.0017 0.0054 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Schistosoma mansoni hypothetical protein 0.0017 0.0054 0.0052
Echinococcus granulosus protein piccolo 0.0017 0.0054 0.0247
Trichomonas vaginalis synaptotagmin, putative 0.0017 0.0054 0.5
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0014 0.0002 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Loa Loa (eye worm) C2 domain-containing protein 0.0017 0.0054 0.017
Brugia malayi C2 domain containing protein 0.0017 0.0054 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0017 0.0054 1
Entamoeba histolytica hypothetical protein 0.0017 0.0054 1
Echinococcus multilocularis synaptotagmin 0.0017 0.0054 0.0247
Entamoeba histolytica hypothetical protein 0.0017 0.0054 1
Trypanosoma brucei Coiled-coil and C2 domain-containing protein 0.0017 0.0054 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.017
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0017 0.0054 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0054 0.5
Toxoplasma gondii Sma protein 0.0017 0.0054 0.0163
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0007
Brugia malayi Protein kinase c protein 2 0.0017 0.0054 1
Leishmania major c2 domain protein, putative 0.0017 0.0054 1
Brugia malayi C2 domain containing protein 0.0017 0.0054 1

Activities

Activity type Activity value Assay description Source Reference
CD50 (functional) = 11.7 uM Compound was evaluated for the inhibition of cell replication sheep choroid plexus (SCP) cells ChEMBL. 8496903
CD50 (functional) = 26 uM Compound was evaluated for the inhibition of cell replication of human fibroblast (MRC-5) cells ChEMBL. 8496903
CD50 (functional) = 26 uM Compound was evaluated for the inhibition of cell replication of human fibroblast (MRC-5) cells ChEMBL. 8496903
IC50 (functional) 0 uM Compound was evaluated for anti-herpesvirus activity against Herpes simplex virus-1 (SC16) strain; Not active ChEMBL. 8496903
IC50 (functional) 0 uM Compound was evaluated for anti-herpesvirus activity against Herpes simplex virus-2 (MS) strain; Not active ChEMBL. 8496903
IC50 (functional) 0 uM Compound was evaluated for anti-herpesvirus activity against Varicella Zoster virus (Ellen) strain; Not active ChEMBL. 8496903
IC50 (functional) 0 uM Compound was evaluated for anti-retrovirus activity against HIV-1 (D34) Diagen strain; Not active ChEMBL. 8496903
IC50 (functional) = 178 uM Compound was evaluated for anti-herpesvirus activity against Cytomegalovirus (AD169) strain plaques in infected human fibroblast (MRC-5) cells. ChEMBL. 8496903
MIC (functional) = 0.1 uM Compound was evaluated for anti-retrovirus activity against Visna virus (K184) strain in infected sheep choroid plexus cells ChEMBL. 8496903

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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