Detailed information for compound 402559

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1549.57 | Formula: C89H80O25
  • H donors: 8 H acceptors: 14 LogP: 15.01 Rotable bonds: 44
    Rule of 5 violations (Lipinski): 4
  • SMILES: OCc1cc(OCc2ccccc2)c(cc1OCC(=O)O)Cc1cc(OCc2ccccc2)c(cc1OCC(=O)O)Cc1cc(OCc2ccccc2)c(cc1OCC(=O)O)Cc1cc(OCc2ccccc2)c(cc1OCC(=O)O)Cc1cc(OCc2ccccc2)c(cc1OCC(=O)O)Cc1cc(O)ccc1OCC(=O)O
  • InChi: 1S/C89H80O25/c90-44-71-43-82(108-49-60-24-14-5-15-25-60)70(42-83(71)114-55-89(102)103)32-69-37-77(107-48-59-22-12-4-13-23-59)65(41-81(69)113-54-88(100)101)31-68-36-76(106-47-58-20-10-3-11-21-58)64(40-80(68)112-53-87(98)99)30-67-35-75(105-46-57-18-8-2-9-19-57)63(39-79(67)111-52-86(96)97)29-66-34-74(104-45-56-16-6-1-7-17-56)62(38-78(66)110-51-85(94)95)28-61-33-72(91)26-27-73(61)109-50-84(92)93/h1-27,33-43,90-91H,28-32,44-55H2,(H,92,93)(H,94,95)(H,96,97)(H,98,99)(H,100,101)(H,102,103)
  • InChiKey: MODVMEKJPRXTGW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens elastase, neutrophil expressed Starlite/ChEMBL References
Homo sapiens cathepsin G Starlite/ChEMBL References
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus transmembrane protease serine 3 elastase, neutrophil expressed 267 aa 236 aa 27.5 %
Schistosoma mansoni cercarial elastase (S01 family) cathepsin G 255 aa 209 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis survival motor neuron protein 1 0.0512 0.0648 0.0648
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.07 0.0892 0.0892
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0025 0.0198
Echinococcus granulosus regulator of G protein signaling 7 0.0029 0.0022 0.0022
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0035 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0008 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.003 0.0142
Brugia malayi hypothetical protein 0.0035 0.003 0.0236
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0008 0.002
Onchocerca volvulus 0.0035 0.003 0.0636
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0008 0.0053
Brugia malayi Protein kinase domain containing protein 0.0349 0.0437 0.3664
Echinococcus multilocularis Ankyrin 0.0016 0.0004 0.0004
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0029 0.0022 0.0173
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0137 0.0391
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.003 0.003
Toxoplasma gondii isocitrate dehydrogenase 0.0056 0.0057 0.0617
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0036 0.0285
Onchocerca volvulus 0.0145 0.0172 0.3915
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0254 0.2125
Schistosoma mansoni hypothetical protein 0.0035 0.003 0.0142
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0055 0.0056 0.0156
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0035 0.003 0.0142
Schistosoma mansoni hypothetical protein 0.0265 0.0327 0.1811
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0015
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.0012 0.0254
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0349 0.0437 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0655 0.0834 0.7004
Schistosoma mansoni amine GPCR 0.0035 0.003 0.0142
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0025 0.0198
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0035 0.0029 0.0233
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0145 0.0172 0.0941
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0137 0.1071
Loa Loa (eye worm) hypothetical protein 0.0128 0.015 0.093
Loa Loa (eye worm) hypothetical protein 0.0148 0.0175 0.1092
Schistosoma mansoni hypothetical protein 0.0018 0.0007 0.0016
Entamoeba histolytica serine/threonine protein kinase, putative 0.0208 0.0254 0.2063
Echinococcus granulosus death domain containing protein 0.0016 0.0004 0.0004
Loa Loa (eye worm) TAR-binding protein 0.0172 0.0208 0.1295
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.0867 0.7277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0635 0.0808 0.6786
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0029 0.0022 0.0173
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0038 0.0397
Echinococcus multilocularis GPCR, family 2 0.0128 0.015 0.015
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.139 0.1788 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0647 0.0823 0.2248
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0038 0.0104
Echinococcus multilocularis muscleblind protein 0.0148 0.0175 0.0175
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0008 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.031 0.2589
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0026 0.0026
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0145 0.0172 0.5739
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0137 0.1071
Plasmodium falciparum glycogen synthase kinase 3 0.0055 0.0056 0.1593
Toxoplasma gondii hypothetical protein 0.0021 0.0011 0.0087
Brugia malayi RNA, U transporter 1 0.0161 0.0192 0.1606
Schistosoma mansoni amine GPCR 0.0035 0.003 0.0142
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0209 0.1744
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.003 0.0142
Loa Loa (eye worm) hypothetical protein 0.0217 0.0266 0.166
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0393 0.0494 0.4093
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0097 0.011 0.0591
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0055 0.0056 0.034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0675 0.086 0.7222
Toxoplasma gondii kringle domain-containing protein 0.0021 0.0012 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.041 0.0517 0.4332
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0025 0.0198
Echinococcus multilocularis isocitrate dehydrogenase 0.0056 0.0057 0.0057
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.003 0.003
Onchocerca volvulus 0.0255 0.0315 0.7207
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.069 0.0879 0.7384
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0054 0.0277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0145 0.0172 0.1434
Leishmania major ATP-dependent phosphofructokinase 0.0118 0.0137 0.0371
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0008 0.0037
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0172 0.0208 0.1295
Schistosoma mansoni hypothetical protein 0.0035 0.003 0.0142
Schistosoma mansoni intermediate filament proteins 0.0082 0.009 0.0482
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Giardia lamblia Hypothetical protein 0.0145 0.0172 0.1693
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0029 0.0022 0.0099
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0145 0.0172 0.0492
Loa Loa (eye worm) hypothetical protein 0.0241 0.0297 0.1859
Trichomonas vaginalis PIKK family atypical protein kinase 0.0635 0.0808 0.6786
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0445 0.0561 0.3121
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0008 0.002
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0035 0.003 0.003
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.07 0.0892 0.7476
Echinococcus multilocularis expressed conserved protein 0.0089 0.0099 0.0099
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0035 0.003 0.0236
Loa Loa (eye worm) hypothetical protein 0.0056 0.0057 0.0349
Loa Loa (eye worm) hypothetical protein 0.0165 0.0198 0.1232
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0198 0.1647
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0011 0.0038
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.003 0.003
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0241 0.0297 0.0852
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.007 0.0197
Echinococcus multilocularis glycoprotein Antigen 5 0.0018 0.0007 0.0007
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0035 0.0029 0.0029
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.007 0.0574
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0066 0.007 0.0369
Echinococcus granulosus allatostatin A receptor 0.0035 0.003 0.003
Echinococcus multilocularis g protein coupled receptor 0.0035 0.003 0.003
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0655 0.0834 0.7004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.003 0.003
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0008 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0172 0.0208 0.114
Brugia malayi regulator of G-protein signaling egl-10 0.0029 0.0022 0.0169
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0008 0.0008
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0697 0.0889 0.7462
Onchocerca volvulus 0.0055 0.0056 0.1242
Brugia malayi Dopamine receptor protein 1 0.0035 0.003 0.0236
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.007 0.0574
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0008 0.0137
Echinococcus granulosus g protein coupled receptor 0.0035 0.003 0.003
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0035 0.003 0.0142
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.003 0.003
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.093 0.119 1
Plasmodium falciparum casein kinase II beta chain 0.004 0.0036 0.0887
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0037
Echinococcus multilocularis serine protein kinase ATM 0.0387 0.0486 0.0486
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0007 0.0014
Echinococcus granulosus survival motor neuron protein 1 0.0512 0.0648 0.0648
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0036 0.0209
Brugia malayi 6-phosphofructokinase 0.0118 0.0137 0.1142
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0038
Loa Loa (eye worm) hypothetical protein 0.0029 0.0022 0.0127
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0037
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0014 0.0113
Echinococcus granulosus alpha 1A adrenergic receptor 0.0035 0.003 0.003
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0008 0.002
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.007 0.0574
Echinococcus granulosus neuropeptide Y receptor 0.0035 0.003 0.003
Echinococcus granulosus serine protein kinase ATM 0.0387 0.0486 0.0486
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.003 0.003
Schistosoma mansoni biogenic amine receptor 0.0035 0.003 0.0142
Echinococcus multilocularis Mastin 0.0018 0.0007 0.0007
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0089 0.0474
Brugia malayi neuropeptide F receptor 0.0035 0.003 0.0236
Toxoplasma gondii HEAT repeat-containing protein 0.0056 0.0057 0.0623
Schistosoma mansoni amine GPCR 0.0035 0.003 0.0142
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.003 0.003
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.012 0.0993
Schistosoma mansoni hypothetical protein 0.0128 0.015 0.0815
Giardia lamblia Phosphatidylinositol 4-kinase 0.0145 0.0172 0.1693
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.093 0.119 0.3428
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0177 0.1475
Loa Loa (eye worm) hypothetical protein 0.004 0.0035 0.021
Echinococcus multilocularis casein kinase ii subunit beta 0.004 0.0036 0.0036
Mycobacterium leprae conserved hypothetical protein 0.0145 0.0172 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0241 0.0297 0.1641
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0007 0.0016
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0026 0.0255
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.003 0.0142
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0043 0.035
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0014 0.0489
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0029 0.0022 0.0022
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.139 0.1788 0.1788
Echinococcus multilocularis sex peptide receptor 0.0035 0.003 0.003
Echinococcus multilocularis protein kinase shaggy 0.0055 0.0056 0.0056
Schistosoma mansoni regulator of G protein signaling 0.0029 0.0022 0.0097
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0011 0.0011
Toxoplasma gondii FATC domain-containing protein 0.0387 0.0486 0.5625
Trichomonas vaginalis PIKK family atypical protein kinase 0.0675 0.086 0.7222
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0177 0.1475
Onchocerca volvulus 0.0035 0.003 0.0636
Brugia malayi nuclear receptor NHR-88 0.0018 0.0008 0.0053
Echinococcus multilocularis neuropeptide receptor A26 0.0035 0.003 0.003
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0035 0.0029 0.0029
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0066 0.007 0.007
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.007 0.0574
Brugia malayi Calcitonin receptor-like protein seb-1 0.0403 0.0507 0.4256
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0033
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0097 0.011 0.0591
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.07 0.0892 0.2569
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.005
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.007 0.0574
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0007 0.0016
Echinococcus multilocularis somatostatin receptor 0.0035 0.003 0.003
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0198 0.1647
Echinococcus granulosus tumor protein p63 0.0367 0.0461 0.0461
Loa Loa (eye worm) phosphofructokinase 0.0118 0.0137 0.0852
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0241 0.0297 0.2425
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0033
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0011 0.008
Brugia malayi RNA recognition motif domain containing protein 0.0172 0.0208 0.1735
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0349 0.0437 0.0437
Brugia malayi Trypsin family protein 0.0018 0.0007 0.0047
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0035 0.003 0.0236
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.003 0.003
Onchocerca volvulus 0.0104 0.012 0.2703
Brugia malayi Casein kinase II, alpha chain 0.0149 0.0177 0.1478
Loa Loa (eye worm) hypothetical protein 0.0177 0.0214 0.1336
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0026 0.0151
Echinococcus multilocularis lamin 0.0082 0.009 0.009
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0145 0.0172 0.1906
Echinococcus multilocularis Zinc finger, PHD finger 0.0241 0.0297 0.0297
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.772 1 1
Plasmodium vivax glycogen synthase kinase 3, putative 0.0055 0.0056 0.1766
Brugia malayi AKH receptor 0.0035 0.003 0.0236
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0014 0.0683
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0025 0.0251
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0145 0.0172 0.5649
Echinococcus granulosus neuropeptide s receptor 0.0035 0.003 0.003
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0056 0.0057 0.2821
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0785 0.1002 0.8404
Brugia malayi RE15519p 0.0035 0.003 0.0236
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0025 0.0198
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0004 0.0015
Echinococcus multilocularis musashi 0.0082 0.009 0.009
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0056 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Leishmania major phosphatidylinositol 4-kinase, putative 0.0145 0.0172 0.0466
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0018 0.0007 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0198 0.1647
Echinococcus multilocularis G-protein coupled receptor, putative 0.0035 0.003 0.003
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.031 0.2589
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.07 0.0892 0.2437
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0007 0.0016
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0025 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.041 0.0517 0.4332
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0004 0.0056
Schistosoma mansoni ran 0.0042 0.0038 0.0189
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0045 0.0043 0.0343
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0056 0.0056 0.0292
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0137 0.0746
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0035 0.0029 0.0029
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0053 0.0271
Onchocerca volvulus 0.0145 0.0172 0.3915
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0062
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0036 0.0285
Brugia malayi hypothetical protein 0.0035 0.003 0.0236
Loa Loa (eye worm) hypothetical protein 0.0265 0.0327 0.2048
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0241 0.0297 0.0851
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.007 0.0574
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0128 0.015 0.015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0043 0.0215
Echinococcus granulosus protein kinase shaggy 0.0055 0.0056 0.0056
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0008 0.002
Loa Loa (eye worm) gastrulation defective protein 1 0.0142 0.0168 0.1045
Schistosoma mansoni neuropeptide F-like receptor 0.0035 0.003 0.0142
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0058
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0025 0.0016 0.0088
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0008 0.0008
Echinococcus multilocularis neuropeptide receptor 0.0035 0.003 0.003
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0035 0.003 0.0142
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0011 0.0011
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0011 0.0011
Echinococcus granulosus orexin receptor type 2 0.0035 0.003 0.003
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0008 0.0018
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0043 0.035
Loa Loa (eye worm) RecQ helicase 0.0023 0.0014 0.0076
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0241 0.0297 0.0851
Brugia malayi Muscleblind-like protein 0.0148 0.0175 0.1463
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.006 0.0485
Schistosoma mansoni tar DNA-binding protein 0.0172 0.0208 0.114
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0014 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0008 0.0053
Entamoeba histolytica hypothetical protein 0.0145 0.0172 0.1367
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0036 0.0285
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.007 0.0574
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0149 0.0177 0.5907
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0177 0.1475
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0254 0.2125
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0037
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0094 0.0106 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.0655 0.0834 0.7004
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0254 0.2125
Onchocerca volvulus 0.0035 0.003 0.0636
Echinococcus granulosus GPCR family 2 0.0128 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0035 0.0029 0.0172
Brugia malayi Uncoordinated protein 44 0.0016 0.0004 0.0023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0008 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.003 0.0142
Onchocerca volvulus 0.0035 0.003 0.0636
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.003 0.0142
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0007 0.0007
Brugia malayi Trypsin family protein 0.0018 0.0007 0.0047
Plasmodium vivax hypothetical protein 0.0145 0.0172 0.5739
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0014 0.5
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0241 0.0297 0.0808
Trypanosoma cruzi polo-like protein kinase, putative 0.0208 0.0254 0.0728
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0008 0.0008
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.003 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0011 0.0081
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0004 0.0004
Trichomonas vaginalis ran, putative 0.0042 0.0038 0.0304
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.003 0.003
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.012 0.0993
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0036 0.0285
Schistosoma mansoni hypothetical protein 0.0035 0.003 0.0142
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.0002 0.0002
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0007 0.0016
Onchocerca volvulus 0.0035 0.003 0.0636
Loa Loa (eye worm) phosphatidylinositol 3 0.0145 0.0172 0.1072
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.003 0.0142
Echinococcus multilocularis regulator of G protein signaling 7 0.0029 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0104 0.012 0.0646
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0035 0.0035
Entamoeba histolytica hypothetical protein 0.0039 0.0035 0.0201
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0675 0.0859 0.0859
Onchocerca volvulus 0.0018 0.0007 0.0121
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.003 0.003
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0052 0.0051 0.0311
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.007 0.0197
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0056 0.0057 0.015
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0014 0.0032
Echinococcus multilocularis 6 phosphofructokinase 0.0118 0.0137 0.0137
Echinococcus multilocularis fmrfamide receptor 0.0035 0.003 0.003
Brugia malayi Latrophilin receptor protein 2 0.0128 0.015 0.1246
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0036 0.0285
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0145 0.0172 0.0172
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0008 0.0053
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0025 0.0198
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.003 0.003
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0056 0.038
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0097 0.011 0.011
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.069 0.0879 0.2531
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0177 0.1475
Trichomonas vaginalis conserved hypothetical protein 0.0226 0.0277 0.2313
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0011 0.008
Echinococcus multilocularis geminin 0.0515 0.0652 0.0652
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0008 0.0008
Brugia malayi hypothetical protein 0.0035 0.003 0.0236
Brugia malayi hypothetical protein 0.0018 0.0007 0.0047
Brugia malayi Cytochrome P450 family protein 0.0021 0.0011 0.0083
Brugia malayi Cytochrome P450 family protein 0.0032 0.0026 0.0205
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0066 0.007 0.0574
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0035 0.003 0.0236
Schistosoma mansoni hypothetical protein 0.0021 0.0012 0.0041
Echinococcus granulosus hypothetical protein 0.0035 0.003 0.003
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0194 0.0236 0.1473
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Schistosoma mansoni hypothetical protein 0.0515 0.0652 0.3629
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0137 0.0852
Brugia malayi GnHR receptor homolog 0.0035 0.003 0.0236
Loa Loa (eye worm) hypoxia-induced factor 1 0.0164 0.0196 0.1224
Echinococcus granulosus neuropeptide FF receptor 2 0.0035 0.003 0.003
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0011 0.0038
Loa Loa (eye worm) phosphatidylinositol 3 0.0647 0.0823 0.5168
Loa Loa (eye worm) RNA binding protein 0.0172 0.0208 0.1295
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0035 0.0029 0.0029
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0008 0.002
Schistosoma mansoni voltage-gated cation channel 0.0035 0.0029 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0226 0.0277 0.2313
Echinococcus granulosus microtubule associated protein 2 0.0681 0.0868 0.0868
Onchocerca volvulus 0.0018 0.0007 0.0121
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0474 0.0599 0.4983
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0035 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0148 0.0175 0.1092
Onchocerca volvulus 0.0035 0.003 0.0636
Brugia malayi hypothetical protein 0.0035 0.003 0.0236
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0007 0.0016
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0025 0.0251
Toxoplasma gondii non-specific serine/threonine protein kinase 0.041 0.0516 0.5977
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0137 0.114
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.003 0.0142
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0007 0.0014
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0393 0.0494 0.4139
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0241 0.0297 0.2425
Brugia malayi sulfakinin receptor protein 0.0035 0.003 0.0236
Echinococcus multilocularis transmembrane protease serine 3 0.0018 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.006 0.0485
Schistosoma mansoni coup transcription factor 0.0018 0.0008 0.002
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0004 0.0001
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0025 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0145 0.0172 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0126 0.078
Loa Loa (eye worm) intermediate filament protein 0.0082 0.009 0.0556
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Entamoeba histolytica hypothetical protein 0.0778 0.0993 0.8332
Echinococcus granulosus single minded 2 0.0039 0.0035 0.0035
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.093 0.119 0.3428
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0008 0.0053
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0145 0.0172 0.5739
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0177 0.1475
Echinococcus multilocularis neuropeptide receptor 0.0035 0.003 0.003
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0251 0.031 0.2591
Loa Loa (eye worm) phosphatidylinositol 3 0.0145 0.0172 0.1072
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0393 0.0494 0.4139
Toxoplasma gondii GAF domain-containing protein 0.0021 0.0011 0.0087
Echinococcus granulosus intermediate filament protein 0.0082 0.009 0.009
Brugia malayi Dopamine receptor 0.0035 0.003 0.0236
Leishmania major hypothetical protein, conserved 0.0021 0.0012 0.0027
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.007 0.0574
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.031 0.2589
Onchocerca volvulus 0.0035 0.003 0.0636
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0008 0.002
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0145 0.0172 0.0172
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0008 0.0053
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0008 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0011 0.0077
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0056 0.0057 0.0608
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0277 0.0343 0.0343
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0007 0.0016
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0145 0.0172 0.1436
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.093 0.119 1
Trichomonas vaginalis conserved hypothetical protein 0.0265 0.0327 0.274
Loa Loa (eye worm) isocitrate dehydrogenase 0.0056 0.0057 0.0346
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0018 0.0007 0.0007
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0025 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0035 0.003 0.0142
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0145 0.0172 0.1966
Leishmania major protein kinase, putative 0.0017 0.0007 0.0013
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0097 0.011 0.011
Schistosoma mansoni alpha-1 adrenergic receptor 0.0035 0.003 0.0142
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0145 0.0172 0.0172
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0011 0.0011
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0265 0.0327 0.0327
Schistosoma mansoni serine/threonine protein kinase 0.0145 0.0173 0.0944
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.007 0.0574
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0011 0.006
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0675 0.086 0.7222
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0008 0.0037
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0011 0.0038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0008 0.0008
Entamoeba histolytica protein kinase domain containing protein 0.0149 0.0177 0.1409
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0036 0.0285
Plasmodium falciparum casein kinase 2, alpha subunit 0.0149 0.0177 0.5821
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0349 0.0437 0.3664
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0137 0.0852
Echinococcus granulosus glycoprotein Antigen 5 0.0018 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0035 0.003 0.0142
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0635 0.0808 0.9053
Onchocerca volvulus 0.0035 0.003 0.0636
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0011 0.0038
Loa Loa (eye worm) hypothetical protein 0.0675 0.0859 0.5394
Onchocerca volvulus 0.0018 0.0008 0.0137
Onchocerca volvulus 0.0081 0.0089 0.1998
Plasmodium vivax unspecified product 0.0149 0.0177 0.5907
Loa Loa (eye worm) hypothetical protein 0.0512 0.0648 0.4066
Echinococcus multilocularis G protein coupled receptor 139 0.0035 0.003 0.003
Echinococcus multilocularis dro:myosuppressin receptor 0.0035 0.003 0.003
Onchocerca volvulus 0.0021 0.0012 0.0225
Schistosoma mansoni lamin 0.0082 0.009 0.0482
Brugia malayi PXA domain containing protein 0.0022 0.0013 0.0097
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.007 0.0574
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0442 0.0558 0.4636
Brugia malayi Pre-SET motif family protein 0.0224 0.0275 0.2302
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0137 0.114
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0035 0.003 0.0174
Leishmania major cytochrome p450-like protein 0.0021 0.0011 0.0026
Brugia malayi PAS domain containing protein 0.0053 0.0053 0.043
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Schistosoma mansoni casein kinase II beta subunit 0.004 0.0036 0.0176
Entamoeba histolytica casein kinase, putative 0.0149 0.0177 0.1409
Schistosoma mansoni fkbp-rapamycin associated protein 0.0371 0.0465 0.2582
Echinococcus granulosus dro:myosuppressin receptor 0.0035 0.003 0.003
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0297 0.0369 0.3961
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0043 0.035
Echinococcus multilocularis serotonin receptor 0.0035 0.003 0.003
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0241 0.0297 0.3423
Echinococcus granulosus peptide allatostatin:somatostatin 0.0035 0.003 0.003
Leishmania major phosphatidylinositol 3-kinase, putative 0.0635 0.0808 0.2207
Loa Loa (eye worm) hypothetical protein 0.0082 0.009 0.0556
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0011 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0172 0.0208 0.114
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0012 0.0012
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.068 0.0867 0.2366
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0025 0.0725
Toxoplasma gondii target of rapamycin (TOR), putative 0.0675 0.086 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0011 0.006
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0008 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0172 0.0208 0.114
Echinococcus multilocularis voltage dependent calcium channel 0.0035 0.0029 0.0029
Brugia malayi 6-phosphofructokinase 0.0118 0.0137 0.1142
Echinococcus multilocularis cyclin dependent kinase 19 0.0145 0.0173 0.0173
Trypanosoma cruzi hypothetical protein, conserved 0.2685 0.3468 1
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.003 0.0174
Leishmania major protein kinase ck2 regulatory subunit, putative 0.004 0.0036 0.0093
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.007 0.0574
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.07 0.0892 0.0892
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0056 0.0057 0.0608
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.07 0.0892 0.7496
Entamoeba histolytica hypothetical protein 0.0039 0.0035 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.0867 0.7277
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0014 0.4937
Loa Loa (eye worm) hypothetical protein 0.0371 0.0465 0.2913
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0035 0.0029 0.014
Schistosoma mansoni neuropeptide f receptor 76f 0.0035 0.003 0.0142
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0387 0.0486 0.4072
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0036 0.0285
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0066 0.007 0.0197
Brugia malayi photoreceptor-specific nuclear receptor 0.0217 0.0266 0.2223
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0677 0.0863 0.7244
Echinococcus granulosus transmembrane protease serine 3 0.0018 0.0007 0.0007
Plasmodium falciparum casein kinase II beta chain 0.004 0.0036 0.0887
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0043 0.0215
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0241 0.0297 0.3423
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.07 0.0892 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0371 0.0465 0.0465
Brugia malayi hypothetical protein 0.0021 0.0011 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0635 0.0808 0.6786
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0371 0.0465 0.0465
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0007 0.0016
Schistosoma mansoni growth hormone secretagogue receptor 0.0035 0.003 0.0142
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0254 0.2125
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0008 0.0053
Brugia malayi Pre-SET motif family protein 0.0032 0.0026 0.0204
Entamoeba histolytica hypothetical protein 0.0046 0.0043 0.0275
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0241 0.0297 0.0297
Echinococcus multilocularis fmrfamide receptor 0.0035 0.003 0.003
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.07 0.0892 0.7495
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0208 0.0254 0.0691
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0011 0.0247
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0008 0.002
Schistosoma mansoni amine GPCR 0.0035 0.003 0.0142
Echinococcus granulosus neuropeptide receptor 0.0035 0.003 0.003
Onchocerca volvulus 0.0054 0.0054 0.1193
Echinococcus granulosus casein kinase ii subunit alpha 0.0149 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0552 0.0701 0.4396
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0014 0.0122
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0055 0.0056 0.0056
Echinococcus granulosus regulator of G protein signaling 7 0.0029 0.0022 0.0022
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0014 0.0489
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0038 0.0307
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0066 0.007 0.0758
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0012 0.0028
Loa Loa (eye worm) trypsin family protein 0.0018 0.0007 0.0033
Entamoeba histolytica hypothetical protein 0.0039 0.0035 0.0201
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0011 0.0011
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0241 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0058
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0241 0.0297 0.0297
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0198 0.1647
Echinococcus multilocularis tar DNA binding protein 0.0172 0.0208 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0008 0.0053
Mycobacterium ulcerans 6-phosphofructokinase 0.0118 0.0137 1
Schistosoma mansoni myosin xvIII 0.0035 0.003 0.0142
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0208 0.0254 0.0254
Onchocerca volvulus 0.0109 0.0126 0.2845
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0056 0.0455
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.07 0.0892 0.7495
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.003 0.0142
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0241 0.0297 0.2484
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.0198 0.4498
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.007 0.0574
Plasmodium vivax casein kinase II beta chain, putative 0.004 0.0036 0.1075
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0285 0.0354 0.2215
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0066 0.007 0.0574
Trichomonas vaginalis PIKK family atypical protein kinase 0.0371 0.0465 0.3897
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0056 0.0057 0.0158
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0008 0.0008
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0137 0.0746
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0037
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0058
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0011 0.0011
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0056 0.0455
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0089 0.0734
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0043 0.0346
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Echinococcus multilocularis neuropeptide Y receptor 0.0035 0.003 0.003
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0038 0.0144
Mycobacterium ulcerans putative regulatory protein 0.0021 0.0011 0.0331
Plasmodium vivax casein kinase II beta chain, putative 0.004 0.0036 0.1075
Entamoeba histolytica hypothetical protein 0.0145 0.0172 0.1367
Echinococcus granulosus expressed protein 0.0406 0.051 0.051
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0014 0.0014
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0021 0.0011 0.0331
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0055 0.0056 0.034
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0026 0.0026
Brugia malayi G protein-coupled receptor 0.0035 0.003 0.0236
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.07 0.0892 0.2569
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.003 0.0142
Echinococcus multilocularis lamin dm0 0.0082 0.009 0.009
Mycobacterium ulcerans putative regulatory protein 0.0021 0.0011 0.0331
Schistosoma mansoni serine/threonine protein kinase 0.0208 0.0254 0.1402
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0011 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0647 0.0823 0.6914
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0007 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0145 0.0172 0.1434
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0035 0.0029 0.014
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0008 0.0053
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.069 0.0879 0.4905
Trichomonas vaginalis PIKK family atypical protein kinase 0.0655 0.0834 0.7004
Echinococcus multilocularis neuropeptide s receptor 0.0035 0.003 0.003
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0241 0.0297 0.1857
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.07 0.0892 0.2437
Loa Loa (eye worm) hypothetical protein 0.0029 0.0022 0.0124
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0778 0.0993 0.8332
Brugia malayi SH2 domain containing protein 0.0369 0.0463 0.3886
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0371 0.0465 0.1336
Schistosoma mansoni survival motor neuron protein 0.0104 0.012 0.0646
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0066 0.007 0.0574
Brugia malayi Trypsin family protein 0.0018 0.0007 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.041 0.0516 0.4324
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0145 0.0172 0.5739
Brugia malayi G protein-coupled receptor F59B2.13 0.0035 0.003 0.0236
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0056 0.0057 0.0057
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0025 0.0016 0.0088
Echinococcus granulosus neuropeptide receptor 0.0035 0.003 0.003
Giardia lamblia Kinase, CMGC CK2 0.0149 0.0177 0.175
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0177 0.1475
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0008 0.0008
Schistosoma mansoni protein kinase 0.0149 0.0177 0.0969
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0008 0.0053
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0066 0.007 0.0574
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0035 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.041 0.0516 0.3232
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0461 0.0582 0.4884
Trichomonas vaginalis PIKK family atypical protein kinase 0.0655 0.0834 0.7004
Toxoplasma gondii isocitrate dehydrogenase 0.0056 0.0057 0.0617
Toxoplasma gondii ck2 beta subunit 0.004 0.0036 0.0371
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0035 0.003 0.003
Echinococcus granulosus enteropeptidase 0.0018 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0035 0.003 0.003
Echinococcus granulosus 6 phosphofructokinase 0.0118 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0037
Trichomonas vaginalis CMGC family protein kinase 0.0149 0.0177 0.1475
Echinococcus multilocularis serotonin receptor 0.0035 0.003 0.003
Trypanosoma brucei importin beta-1 subunit, putative 0.0056 0.0057 0.0614
Brugia malayi ORL1-like opioid receptor 0.0035 0.003 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0655 0.0834 0.7004
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.007 0.0574
Echinococcus granulosus tar DNA binding protein 0.0172 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Echinococcus multilocularis g protein coupled receptor 0.0035 0.003 0.003
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0277 0.0343 0.0343
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0026 0.012
Onchocerca volvulus 0.0035 0.003 0.0636
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0014 0.0101
Onchocerca volvulus Serine\/threonine kinase homolog 0.0208 0.0254 0.5802
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.003 0.003
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0208 0.0254 0.1588
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0004 0.0004
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0008 0.0008
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.0012 0.0012
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0387 0.0486 0.2698
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0254 0.2125
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0043 0.012
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.069 0.0879 0.2531
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0118 0.0137 0.795
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.003 0.003
Echinococcus granulosus geminin 0.0515 0.0652 0.0652
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.0011 0.0077
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.0002 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.031 0.2589
Onchocerca volvulus 0.0035 0.003 0.0636
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.007 0.0574
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0881 0.1127 0.1127
Brugia malayi RNA binding protein 0.0172 0.0208 0.1735
Schistosoma mansoni opsin-like receptor 0.0035 0.003 0.0142
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0008 0.0008
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0035 0.003 0.003
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0035 0.003 0.003
Onchocerca volvulus Casein kinase II subunit beta homolog 0.004 0.0036 0.0777
Echinococcus multilocularis neuropeptide FF receptor 2 0.0035 0.003 0.003
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0025 0.0198
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0045 0.0043 0.0343
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.003 0.0142
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0145 0.0172 0.1436
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0118 0.0137 1
Onchocerca volvulus 0.0035 0.003 0.0636
Trypanosoma brucei importin beta-1 subunit, putative 0.0056 0.0057 0.0614
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0007 0.0016
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0145 0.0173 0.1075
Brugia malayi serine/threonine-protein kinase plk-2 0.0208 0.0254 0.2127
Schistosoma mansoni hypothetical protein 0.0128 0.015 0.0815
Schistosoma mansoni biogenic amine receptor 0.0035 0.003 0.0142
Echinococcus granulosus neuropeptide receptor A26 0.0035 0.003 0.003
Brugia malayi Isocitrate dehydrogenase 0.0056 0.0057 0.0465
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.093 0.119 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0035 0.003 0.0174
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0198 0.1647
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.007 0.0574
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0021 0.0011 0.0325
Trypanosoma brucei cytochrome P450, putative 0.0021 0.0011 0.0098
Schistosoma mansoni z-protein (S1r protein) 0.0029 0.0022 0.0097
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0011 0.0038
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0035 0.0035
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0056 0.0057 0.0057
Brugia malayi hypothetical protein 0.0512 0.0648 0.5441
Loa Loa (eye worm) phosphatidylinositol 3 0.0145 0.0172 0.1072
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.007 0.0574
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0011 0.008
Schistosoma mansoni kinase 0.0107 0.0123 0.0667
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0025 0.0198
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0056 0.0057 0.1623
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0025 0.053
Plasmodium vivax hypothetical protein, conserved 0.0145 0.0172 0.5739
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0145 0.0172 0.1966
Loa Loa (eye worm) calcium channel 0.0035 0.0029 0.0172
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0043 0.0215
Loa Loa (eye worm) hypothetical protein 0.0032 0.0026 0.015
Trypanosoma brucei target of rapamycin kinase 3, putative 0.068 0.0867 0.971
Trichomonas vaginalis PIKK family atypical protein kinase 0.0387 0.0486 0.407
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0025 0.0016 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.0867 0.7277
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.003 0.0142
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0018 0.0007 0.0047
Loa Loa (eye worm) TYRA-2 protein 0.0035 0.003 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0675 0.086 0.7222
Echinococcus multilocularis orexin receptor type 2 0.0035 0.003 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.003 0.003
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0035 0.003 0.0142
Echinococcus granulosus high voltage activated calcium channel beta 0.0094 0.0106 0.0106
Toxoplasma gondii hypothetical protein 0.0058 0.006 0.0649
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0145 0.0172 0.1367
Toxoplasma gondii hypothetical protein 0.0021 0.0011 0.0087
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0198 0.1647
Trypanosoma cruzi target of rapamycin kinase 3 0.068 0.0867 0.2495
Brugia malayi neuropeptide F receptor 0.0035 0.003 0.0236
Onchocerca volvulus 0.0109 0.0126 0.2845
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0145 0.0172 0.0492
Loa Loa (eye worm) hypothetical protein 0.0054 0.0054 0.0327
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0007 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0008 0.0037
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0066 0.007 0.0574
Loa Loa (eye worm) hypothetical protein 0.0276 0.0342 0.2139
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0208 0.0254 0.0254
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.003 0.003
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0011 0.0011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0008 0.0008
Echinococcus multilocularis casein kinase ii subunit alpha 0.0149 0.0177 0.0177
Brugia malayi hypothetical protein 0.0109 0.0126 0.1046
Echinococcus granulosus serotonin receptor 0.0035 0.003 0.003
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0089 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0008 0.0053
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0025 0.0725
Trypanosoma cruzi polo-like protein kinase, putative 0.0208 0.0254 0.0728
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0145 0.0172 0.0941
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0036 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.006 0.0485
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.009 0.0556
Trichomonas vaginalis set domain proteins, putative 0.0255 0.0315 0.2638
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0014 0.0111
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0014 0.0111
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0008 0.0137
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0008 0.002
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0056 0.038
Brugia malayi Kringle domain containing protein 0.0021 0.0012 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0011 0.0077
Brugia malayi larval opioid receptor 0.0035 0.003 0.0236
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0025 0.0251
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0036 0.0285
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Onchocerca volvulus 0.0039 0.0035 0.0757
Onchocerca volvulus 0.0035 0.003 0.0636
Schistosoma mansoni hypothetical protein 0.0128 0.015 0.0815
Brugia malayi Trypsin family protein 0.0018 0.0007 0.0047
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.003 0.003
Loa Loa (eye worm) melatonin receptor type 1A 0.0035 0.003 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0165 0.0198 0.1651
Entamoeba histolytica protein kinase rad3, putative 0.0371 0.0465 0.3849
Echinococcus granulosus importin subunit beta 1 0.0056 0.0057 0.0057
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0008 0.0053
Loa Loa (eye worm) phosphatidylinositol 3 0.1239 0.1591 1
Echinococcus multilocularis neuropeptides capa receptor 0.0035 0.003 0.003
Schistosoma mansoni neuropeptide receptor 0.0035 0.003 0.0142
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0393 0.0494 0.4139
Loa Loa (eye worm) hypothetical protein 0.008 0.0088 0.0544
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0104 0.012 0.0993
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0036 0.0209
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0094 0.0106 0.0106
Echinococcus granulosus beta-adrenergic receptor kinase 0.0025 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0033
Brugia malayi Protein kinase domain containing protein 0.0021 0.0012 0.0085
Onchocerca volvulus 0.0035 0.003 0.0636
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0035 0.2126
Echinococcus granulosus g-protein coupled receptor 0.0035 0.003 0.003
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0066 0.007 0.0574
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0145 0.0172 0.0172
Echinococcus granulosus casein kinase ii subunit beta 0.004 0.0036 0.0036
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0145 0.0172 0.5649
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0224 0.0275 0.1719
Schistosoma mansoni single-minded 0.0053 0.0053 0.0271
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0066 0.007 0.0758
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0036 0.0285
Echinococcus granulosus biogenic amine 5HT receptor 0.0035 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0304 0.0379 0.2372
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0026 0.012
Giardia lamblia Kinase, CMGC GSK 0.0055 0.0056 0.0351
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.003 0.003
Mycobacterium leprae conserved hypothetical protein 0.0021 0.0011 0.0563
Trypanosoma brucei Casein kinase II subunit beta, putative 0.004 0.0036 0.0371
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0198 0.1647
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0008 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0209 0.1744
Echinococcus multilocularis expressed protein 0.0406 0.051 0.051
Entamoeba histolytica hypothetical protein 0.0039 0.0035 0.0201
Brugia malayi hypothetical protein 0.0035 0.003 0.0236
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0118 0.0137 0.7828
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.004 0.0036 0.0098
Giardia lamblia Kinase, CMGC GSK 0.0055 0.0056 0.0351
Schistosoma mansoni lamin 0.0082 0.009 0.0482
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0128 0.015 0.1246
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0016 0.0065
Brugia malayi hypothetical protein 0.0035 0.003 0.0236
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0697 0.0889 0.7462
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Trypanosoma brucei polo-like protein kinase 0.0208 0.0254 0.2828
Echinococcus multilocularis beta adrenergic receptor kinase 0.0025 0.0016 0.0016
Entamoeba histolytica hypothetical protein 0.0145 0.0172 0.1367
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0011 0.006
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.031 0.2589
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0011 0.0027
Leishmania major importin beta-1 subunit, putative 0.0046 0.0043 0.0114
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0066 0.007 0.007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.003 0.003
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0241 0.0297 0.1641
Plasmodium falciparum importin beta, putative 0.0056 0.0057 0.1641
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0008 0.0037
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0035 0.003 0.0236
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0546 0.0692 0.7686
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0137 0.114
Echinococcus granulosus 7tm_1 domain containing protein 0.0035 0.003 0.003
Brugia malayi Trypsin-like protease protein 5 0.0018 0.0007 0.0047
Brugia malayi G-protein coupled receptor 0.0035 0.003 0.0236
Echinococcus multilocularis g protein coupled receptor 0.0035 0.003 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.003 0.003
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0145 0.0172 0.1072
Onchocerca volvulus 0.0035 0.003 0.0636
Schistosoma mansoni opsin-like receptor 0.0035 0.003 0.0142
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0254 0.2125
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0008 0.0137
Brugia malayi hypothetical protein 0.0035 0.003 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.041 0.0517 0.4332
Brugia malayi hypothetical protein 0.0177 0.0214 0.1789
Trichomonas vaginalis PIKK family atypical protein kinase 0.0436 0.0549 0.4605
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0018 0.0007 0.0007
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0089 0.0089
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0128 0.015 0.015
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.093 0.119 1
Brugia malayi Dopamine receptor protein 2 0.0035 0.003 0.0236
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0007 0.0016
Trypanosoma brucei protein kinase, putative 0.0055 0.0056 0.0598
Trichomonas vaginalis PIKK family atypical protein kinase 0.07 0.0892 0.7495
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0055 0.0056 0.0148
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0145 0.0172 0.1434
Brugia malayi Csnk2b protein 0.004 0.0036 0.0288
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.003 0.003
Onchocerca volvulus Neuropeptide F receptor homolog 0.0035 0.003 0.0636
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.007 0.0574
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.004 0.0036 0.0371
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0008 0.0008
Brugia malayi Death domain containing protein 0.0016 0.0004 0.0023
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0035 0.028
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0008 0.0053
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Onchocerca volvulus 0.0035 0.003 0.0636
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0011 0.0077
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0043 0.0043
Echinococcus granulosus somatostatin receptor 0.0035 0.003 0.003
Brugia malayi follicle stimulating hormone receptor 0.0285 0.0354 0.2965
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.007 0.0574
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.003 0.003
Giardia lamblia Casein kinase II beta chain 0.004 0.0036 0.0118
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0014 0.0317
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0011 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0675 0.086 0.7222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0635 0.0808 0.6786
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0038 0.0967
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.069 0.0879 0.0879
Leishmania major phosphatidylinositol kinase, putative 0.0145 0.0172 0.0466
Schistosoma mansoni neuropeptide receptor 0.0035 0.003 0.0142
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.0868 0.0868
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0035 0.003 0.003
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0137 0.1071
Echinococcus multilocularis nuclear factor of activated T cells 5 0.008 0.0088 0.0088
Echinococcus granulosus lamin 0.0082 0.009 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0455 0.0574 0.4814
Giardia lamblia GTOR 0.07 0.0892 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0035 0.003 0.003
Onchocerca volvulus 0.0018 0.0007 0.0121
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0035 0.003 0.0236
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0011 0.0027
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0036 0.0209
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0033
Echinococcus multilocularis allatostatin A receptor 0.0035 0.003 0.003
Onchocerca volvulus 0.0082 0.009 0.2032
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0145 0.0172 0.0492
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0035 0.003 0.003
Loa Loa (eye worm) phosphatidylinositol kinase 0.0145 0.0172 0.1072
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0013 0.007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0552 0.0701 0.5882
Brugia malayi G-protein coupled receptor 0.0035 0.003 0.0236
Brugia malayi ecdysteroid receptor 0.0018 0.0008 0.0053
Entamoeba histolytica protein kinase, putative 0.0055 0.0056 0.038
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.0002 0.0002
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0349 0.0437 0.2737
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.006
Schistosoma mansoni adenoreceptor 0.0035 0.003 0.0142
Leishmania major phosphatidylinositol 3-kinase, putative 0.0241 0.0297 0.0808
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0011 0.008
Brugia malayi hypothetical protein 0.0035 0.003 0.0236
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.139 0.1788 0.1788
Trichomonas vaginalis PIKK family atypical protein kinase 0.0382 0.048 0.4024
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0035 0.003 0.0142
Echinococcus multilocularis high voltage activated calcium channel beta 0.0094 0.0106 0.0106
Loa Loa (eye worm) neuropeptide F receptor 0.0035 0.003 0.0174
Brugia malayi intermediate filament protein 0.0082 0.009 0.0747
Loa Loa (eye worm) hypothetical protein 0.0038 0.0033 0.0198
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0011 0.0011
Schistosoma mansoni amine GPCR 0.0035 0.003 0.0142
Entamoeba histolytica hypothetical protein 0.0387 0.0486 0.4024
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.009 0.0747
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0675 0.0859 0.0859
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0149 0.0177 0.1103
Brugia malayi phosphofructokinase 0.0118 0.0137 0.1142
Brugia malayi Tachykinin-like peptides receptor 99D 0.0035 0.003 0.0236
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0038 0.0104
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0036 0.0285
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0241 0.0297 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0056 0.0057 0.0158
Brugia malayi hypothetical protein 0.0021 0.0011 0.008
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.003 0.0142
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0038 0.1153
Schistosoma mansoni hypothetical protein 0.0145 0.0172 0.0941
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0011 0.0038
Brugia malayi hypothetical protein 0.0039 0.0035 0.028
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0035 0.0171
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0037
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0035 0.0029 0.0029
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0055 0.0056 0.0289
Onchocerca volvulus 0.0035 0.003 0.0636
Schistosoma mansoni hypothetical protein 0.0128 0.015 0.0815
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0036 0.0285
Echinococcus granulosus tm gpcr rhodopsin 0.0035 0.003 0.003
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0038 0.0397
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0007 0.0014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0026 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.0867 0.7277
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0008 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0011 0.0077
Echinococcus granulosus 7TM GPCR rhodopsin 0.0035 0.003 0.003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0043 0.0043
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0029 0.0022 0.017
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0056 0.0057 0.0057
Brugia malayi Protein kinase domain containing protein 0.0019 0.0009 0.0064
Echinococcus granulosus fmrfamide receptor 0.0035 0.003 0.003
Brugia malayi Serotonin receptor 0.0535 0.0678 0.5694
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0011 0.0038
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0349 0.0437 0.2737
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.043 0.0542 0.6056
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0185 0.0224 0.2487
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0029 0.0022 0.017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0016
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0165 0.0198 0.4502
Onchocerca volvulus 0.0082 0.009 0.2032
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0029 0.0022 0.017
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.07 0.0892 0.7476
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Schistosoma mansoni biogenic amine receptor 0.0035 0.003 0.0142
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.069 0.0879 0.0879
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0241 0.0297 0.2484
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0035 0.003 0.003
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0035 0.003 0.003
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0014 0.0104
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0035 0.003 0.003
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0008 0.002
Schistosoma mansoni hypothetical protein 0.0603 0.0766 0.4272
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0145 0.0172 0.1434
Echinococcus granulosus expressed conserved protein 0.0089 0.0099 0.0099
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0254 0.2125
Echinococcus granulosus G protein coupled receptor 139 0.0035 0.003 0.003
Brugia malayi Importin beta-1 subunit 0.0056 0.0057 0.0469
Echinococcus granulosus Mastin 0.0018 0.0007 0.0007
Schistosoma mansoni neuropeptide receptor 0.0035 0.003 0.0142
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0036 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0008 0.0037
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0043 0.0257
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0014 0.0128
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0035 0.003 0.003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0403 0.0507 0.318
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0349 0.0437 0.0437
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0035 0.003 0.0142
Onchocerca volvulus 0.0035 0.003 0.0636
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0008 0.002
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.07 0.0892 1
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.004 0.0036 0.0098
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0045 0.0043 0.0118
Giardia lamblia Kinase, PLK 0.0208 0.0254 0.264
Brugia malayi nuclear hormone receptor 0.0018 0.0008 0.0053
Echinococcus granulosus voltage dependent calcium channel 0.0035 0.0029 0.0029
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0137 0.1513
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0382 0.048 0.3977
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0043 0.0043
Echinococcus multilocularis snurportin 1 0.0603 0.0766 0.0766
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0007 0.0014
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0029 0.0022 0.0124
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0037
Echinococcus granulosus muscleblind protein 0.0148 0.0175 0.0175
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.0012 0.0048
Brugia malayi TAR-binding protein 0.0172 0.0208 0.1735
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0016 0.0065
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0194 0.0236 0.1973
Echinococcus granulosus lamin dm0 0.0082 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0145 0.0172 0.1906
Echinococcus multilocularis muscleblind protein 1 0.0148 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0369 0.0463 0.2904
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0056 0.0057 0.1796
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0036 0.0285
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0265 0.0327 0.0327
Leishmania major hypothetical protein, conserved 0.283 0.3656 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0007 0.0016
Onchocerca volvulus 0.0018 0.0007 0.0121
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0042 0.021
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0241 0.0297 0.2486
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0241 0.0297 1
Entamoeba histolytica Ran family GTPase 0.0042 0.0038 0.0228
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0058
Loa Loa (eye worm) phosphatidylinositol 3 0.0248 0.0305 0.191
Leishmania major protein kinase, putative 0.0021 0.0011 0.0026
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0035 0.0029 0.0029
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0041 0.0332
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.003 0.0142
Echinococcus multilocularis voltage dependent calcium channel 0.0035 0.0029 0.0029
Echinococcus granulosus g protein coupled receptor 0.0035 0.003 0.003
Echinococcus granulosus cyclin dependent kinase 19 0.0145 0.0173 0.0173
Echinococcus multilocularis tumor protein p63 0.0367 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0038 0.0033 0.0198
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.007 0.0574
Loa Loa (eye worm) G-protein coupled receptor 0.0035 0.003 0.0174
Loa Loa (eye worm) phosphatidylinositol 3 0.0145 0.0172 0.1072
Brugia malayi latrophilin 2 splice variant baaae 0.0276 0.0342 0.2863
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0387 0.0486 0.5426
Plasmodium falciparum GAF domain-related protein, putative 0.0021 0.0011 0.0042
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0647 0.0823 0.9223
Brugia malayi PXA domain containing protein 0.0022 0.0013 0.0097
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.0868 0.4843
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0161 0.0193 0.0551
Plasmodium vivax SET domain protein, putative 0.0032 0.0026 0.0737
Entamoeba histolytica hypothetical protein 0.0023 0.0014 0.0021
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0035 0.0035
Trypanosoma cruzi casein kinase II, putative 0.0149 0.0177 0.0506
Brugia malayi Cytochrome P450 family protein 0.0021 0.0011 0.0083
Echinococcus multilocularis g-protein coupled receptor 0.0035 0.003 0.003
Echinococcus multilocularis enteropeptidase 0.0018 0.0007 0.0007
Brugia malayi hypothetical protein 0.0035 0.003 0.0236
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0026 0.012
Trypanosoma brucei Casein kinase II 0.0149 0.0177 0.1961
Schistosoma mansoni ran 0.0042 0.0038 0.0189
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0035 0.003 0.0174
Brugia malayi hypothetical protein 0.0035 0.003 0.0236
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0066 0.007 0.0574
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0008 0.0053
Echinococcus granulosus tachykinin peptides receptor 99D 0.0035 0.003 0.003
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0011 0.0011
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0094 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Schistosoma mansoni histamine h1 receptor 0.0035 0.003 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0011 0.0077
Echinococcus granulosus sex peptide receptor 0.0035 0.003 0.003
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0056 0.0057 0.0294
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0008 0.002
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0035 0.003 0.003
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0004 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0675 0.086 0.7222
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0011 0.0011
Leishmania major casein kinase II, putative 0.0149 0.0177 0.048
Brugia malayi steroid hormone receptor 0.0018 0.0008 0.0053
Plasmodium vivax importin-beta 2, putative 0.0056 0.0057 0.1814
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Brugia malayi FAT domain containing protein 0.0265 0.0327 0.2742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0675 0.086 0.7222
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0035 0.003 0.0142
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0041 0.0246
Onchocerca volvulus 0.0044 0.0042 0.0916
Brugia malayi isocitrate dehydrogenase 0.0056 0.0057 0.0465
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0036 0.0285
Brugia malayi intracellular kinase 0.0055 0.0056 0.0458
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.0867 0.7277
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0393 0.0494 0.1419
Schistosoma mansoni hypothetical protein 0.0089 0.0099 0.0531
Leishmania major phosphatidylinositol kinase related protein, putative 0.0161 0.0193 0.0523
Echinococcus granulosus bloom syndrome protein 0.0023 0.0014 0.0014
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0387 0.0486 0.1395
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Brugia malayi M-phase phosphoprotein, mpp8 0.0109 0.0126 0.1044
Brugia malayi putative neuropeptide receptor NPR1 0.0035 0.003 0.0236
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0008 0.0008
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0145 0.0172 0.0172
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0055 0.0056 0.0607
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0058
Toxoplasma gondii CMGC kinase, CK2 family 0.0149 0.0177 0.2023
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0012 0.0062
Echinococcus multilocularis 0.0145 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Echinococcus multilocularis importin subunit beta 1 0.0056 0.0057 0.0057
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0018 0.0007 0.0016
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0007 0.0016
Echinococcus granulosus snurportin 1 0.0603 0.0766 0.0766
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Brugia malayi hypoxia-induced factor 1 0.0164 0.0196 0.1639
Brugia malayi Serotonin receptor 0.0035 0.003 0.0236
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0035 0.003 0.0636
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0018 0.0007 0.0007
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0024 0.0024
Echinococcus multilocularis regulator of G protein signaling 7 0.0029 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0081 0.0089 0.0547
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0241 0.0297 0.2484
Loa Loa (eye worm) phosphatidylinositol 3 0.07 0.0892 0.5603
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Onchocerca volvulus 0.0018 0.0007 0.0121
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0248 0.0305 0.0876
Trichomonas vaginalis PIKK family atypical protein kinase 0.0416 0.0523 0.4387
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0056 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0655 0.0834 0.7004
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0016 0.0065
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0035 0.003 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.066 0.0841 0.706
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0145 0.0172 0.1436
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.093 0.119 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0035 0.003 0.0142
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0008 0.0008
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0008 0.002
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0029 0.0022 0.0022
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.007 0.0574
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0145 0.0172 0.1966
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0035 0.003 0.003
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0038 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.066 0.0841 0.706
Echinococcus granulosus neuropeptides capa receptor 0.0035 0.003 0.003
Schistosoma mansoni importin beta-1 0.0056 0.0057 0.0297
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0011 0.0058
Echinococcus granulosus g protein coupled receptor 0.0035 0.003 0.003
Brugia malayi Melatonin receptor type 1A 0.0035 0.003 0.0236
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0035 0.003 0.0142
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0251 0.031 0.1935
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0007 0.0016
Schistosoma mansoni neuropeptide receptor 0.0035 0.003 0.0142
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.07 0.0892 0.4979
Schistosoma mansoni serine/threonine protein kinase 0.0349 0.0437 0.2426
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.0002 0.0002
Schistosoma mansoni opsin-like receptor 0.0035 0.003 0.0142
Schistosoma mansoni hypothetical protein 0.0276 0.0342 0.1892
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0008 0.0008
Schistosoma mansoni biogenic amine (5HT) receptor 0.0035 0.003 0.0142
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0055 0.0056 0.0056
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0066 0.007 0.0574
Brugia malayi putative neuropeptide receptor 0.0035 0.003 0.0236
Schistosoma mansoni hypothetical protein 0.0515 0.0652 0.3629
Loa Loa (eye worm) latrophilin receptor protein 2 0.0128 0.015 0.093
Loa Loa (eye worm) hypothetical protein 0.0109 0.0126 0.0779
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0137 0.114
Echinococcus granulosus nuclear factor of activated T cells 5 0.008 0.0088 0.0088
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0035 0.003 0.0142
Echinococcus multilocularis rhodopsin orphan GPCR 0.0035 0.003 0.003
Onchocerca volvulus Casein kinase II subunit beta homolog 0.004 0.0036 0.0777
Brugia malayi N-terminal motif family protein 0.0165 0.0198 0.1651
Leishmania major GTP-binding protein, putative 0.0042 0.0038 0.0099
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0007 0.0016
Leishmania major hypothetical protein, unknown function 0.0145 0.0172 0.0466
Loa Loa (eye worm) Csnk2b protein 0.004 0.0036 0.0213
Brugia malayi Protein kinase domain containing protein 0.0145 0.0173 0.144
Echinococcus granulosus rhodopsin orphan GPCR 0.0035 0.003 0.003
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0241 0.0297 0.3308
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0025 0.053
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0174
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0145 0.0172 0.0492
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.031 0.2589
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0025 0.0964
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0066 0.007 0.0574
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0393 0.0494 0.5518
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0038 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0172 0.0208 0.114
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0393 0.0494 0.414
Onchocerca volvulus 0.0018 0.0007 0.0121
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0145 0.0172 0.0941
Schistosoma mansoni hypothetical protein 0.0039 0.0035 0.0171
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0004 0.000000029463
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0371 0.0465 0.3898
Echinococcus granulosus Ankyrin 0.0016 0.0004 0.0004
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0603 0.0766 0.4809

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 120 nM Inhibitory activity against human leukocyte elastase ChEMBL. 9341916
Ki (binding) = 120 nM Inhibitory activity against human leukocyte elastase ChEMBL. 9341916
Ki (binding) = 190 nM Binding Affinity of the compound to inhibit HLE ChEMBL. 9341916
Ki (binding) = 190 nM Binding Affinity of the compound to inhibit HLE ChEMBL. 9341916
Ki (binding) > 15000 nM Inhibition of cathepsin G at pH 7.5 in HEPES buffer containing 200 mM NaCl with substrate Suc-Ala-Ala-Pro-Phe-pNA. ChEMBL. 9341916
Ki (binding) > 15000 nM Inhibition of thrombin at pH 7.5 in HEPES buffer containing 200 mM NaCl with substrate Bz-Phe-Val-Arg-pNA. ChEMBL. 9341916
Ki (binding) > 15000 nM Inhibition of cathepsin G at pH 7.5 in HEPES buffer containing 200 mM NaCl with substrate Suc-Ala-Ala-Pro-Phe-pNA. ChEMBL. 9341916
Ki (binding) > 15000 nM Inhibition of thrombin at pH 7.5 in HEPES buffer containing 200 mM NaCl with substrate Bz-Phe-Val-Arg-pNA. ChEMBL. 9341916
Km (binding) = 0.77 uM Inhibition kinetic analysis of HLE activity with compound at 0.2 uM concentration ChEMBL. 9341916
Km (binding) = 0.77 uM Inhibition kinetic analysis of HLE activity with compound at 0.2 uM concentration ChEMBL. 9341916
Km (binding) = 1.1 uM Inhibition kinetic analysis of HLE activity with compound at 0.5 uM concentration ChEMBL. 9341916
Km (binding) = 1.1 uM Inhibition kinetic analysis of HLE activity with compound at 0.5 uM concentration ChEMBL. 9341916
Km (binding) = 2.3 uM Inhibition kinetic analysis of HLE activity with compound at 1 uM concentration ChEMBL. 9341916
Km (binding) = 2.3 uM Inhibition kinetic analysis of HLE activity with compound at 1 uM concentration ChEMBL. 9341916
Vm (binding) = 0.2 uM Maximum inhibition rate of HLE activity with compound at 0.2 uM concentration ChEMBL. 9341916
Vm (binding) = 0.2 uM Maximum inhibition rate of HLE activity with compound at 0.5 uM concentration ChEMBL. 9341916
Vm (binding) = 0.2 uM Maximum inhibition rate of HLE activity with compound at 1 uM concentration ChEMBL. 9341916
Vm (binding) = 0.2 uM Maximum inhibition rate of HLE activity with compound at 0.2 uM concentration ChEMBL. 9341916
Vm (binding) = 0.2 uM Maximum inhibition rate of HLE activity with compound at 0.5 uM concentration ChEMBL. 9341916
Vm (binding) = 0.2 uM Maximum inhibition rate of HLE activity with compound at 1 uM concentration ChEMBL. 9341916

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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