Detailed information for compound 422032

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 370.525 | Formula: C24H34O3
  • H donors: 0 H acceptors: 0 LogP: 5.6 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1C2CC3CC1CC(C2)(C3)[C@@H]1OO[C@@H]([C@@H]2[C@H]1O2)C12CC3CC(C2)CC(C1)C3
  • InChi: 1S/C24H34O3/c1-13-2-15-3-14(1)8-23(7-13,9-15)21-19-20(25-19)22(27-26-21)24-10-16-4-17(11-24)6-18(5-16)12-24/h13-22H,1-12H2/t13?,14?,15?,16?,17?,18?,19-,20+,21-,22+,23?,24?
  • InChiKey: ZUQRFZRGGNXHAV-HHVRMCCKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus slit 2 protein 0.0052 0.0462 0.0855
Schistosoma mansoni tyrosinase precursor 0.0293 0.3175 0.6375
Echinococcus granulosus GA binding protein alpha chain 0.008 0.0776 0.1438
Echinococcus granulosus thyroid hormone receptor alpha 0.0052 0.0458 0.0849
Echinococcus granulosus nuclear receptor 2DBD gamma 0.011 0.1115 0.2066
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0026 0.0167 0.031
Loa Loa (eye worm) hypothetical protein 0.0016 0.0053 0.0098
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0076 0.0419
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0038 0.0009
Schistosoma mansoni thyroid hormone receptor 0.025 0.2688 0.5396
Schistosoma mansoni hypothetical protein 0.0015 0.0043 0.0087
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0113 0.0808
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0264 0.035
Echinococcus granulosus pikachurin 0.0052 0.0462 0.0855
Entamoeba histolytica hypothetical protein 0.0109 0.1104 1
Leishmania major cytochrome p450-like protein 0.0033 0.0242 0.2187
Echinococcus granulosus serotonin transporter 0.0067 0.0627 0.1161
Schistosoma mansoni lamin 0.0056 0.0502 0.1008
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0018 0.0079 0.0045
Echinococcus granulosus FTZ F1 alpha 0.011 0.1115 0.2066
Brugia malayi CXXC zinc finger family protein 0.0032 0.0231 0.0427
Echinococcus granulosus jun protein 0.0259 0.2786 0.5161
Loa Loa (eye worm) hypothetical protein 0.011 0.1115 0.2066
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0113 0.0808
Echinococcus granulosus geminin 0.0352 0.3832 0.7099
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0973 0.168
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0051 0.0051
Toxoplasma gondii cytochrome p450 superfamily protein 0.0015 0.0037 0.0599
Schistosoma mansoni cytochrome P450 0.0015 0.0037 0.0075
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0973 0.168
Brugia malayi hypothetical protein 0.0203 0.216 0.4002
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.0973 0.1797
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0026 0.016 0.016
Echinococcus multilocularis cpg binding protein 0.0034 0.0251 0.0251
Echinococcus multilocularis dnaJ subfamily B 0.0454 0.4981 0.4981
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.0973 0.0973
Loa Loa (eye worm) hypothetical protein 0.011 0.1115 0.2066
Echinococcus granulosus nmda type glutamate receptor 0.0026 0.016 0.0296
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0113 0.0068
Schistosoma mansoni laminin gamma-3 chain 0.0052 0.0462 0.0927
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0264 1
Echinococcus multilocularis 0.0015 0.0037 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0973 0.168
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0414 0.0767
Brugia malayi Protein kinase domain containing protein 0.0017 0.006 0.0112
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.011 0.1115 0.2066
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0176 0.1484
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.0973 0.1803
Schistosoma mansoni hypothetical protein 0.0015 0.0043 0.0087
Loa Loa (eye worm) hypothetical protein 0.0091 0.0902 0.1671
Brugia malayi laminin-like protein K08C7.3 precursor 0.0052 0.0462 0.0855
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0242 0.0448
Brugia malayi nuclear receptor RXR 0.0058 0.0529 0.0979
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0113 0.0808
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0113 0.0259
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0264 0.0775
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0012 0.0003 0.0006
Leishmania major protein kinase, putative 0.0027 0.0176 0.1484
Entamoeba histolytica protein kinase domain containing protein 0.0092 0.0911 0.8123
Echinococcus granulosus nuclear factor of activated T cells 5 0.0082 0.0792 0.1466
Echinococcus multilocularis dual specificity 0.0092 0.0911 0.0911
Loa Loa (eye worm) hypothetical protein 0.0052 0.0458 0.0849
Loa Loa (eye worm) hypothetical protein 0.0491 0.5398 1
Echinococcus multilocularis neurogenic locus notch protein 0.0052 0.0462 0.0462
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0082 0.0792 0.0792
Schistosoma mansoni gabp alpha 0.008 0.0776 0.1559
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0974 0.1804
Mycobacterium tuberculosis Conserved protein 0.0035 0.0264 0.0775
Brugia malayi Nuclear hormone receptor family member nhr-1 0.011 0.1115 0.2066
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0052 0.0458 0.092
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0167 0.1389
Brugia malayi Uncoordinated protein 44 0.0016 0.0051 0.0095
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0037 0.0069
Brugia malayi laminin alpha chain 0.0052 0.0462 0.0855
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0264 0.0529
Loa Loa (eye worm) hypothetical protein 0.0052 0.0458 0.0849
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0264 0.035
Echinococcus multilocularis serotonin transporter 0.0067 0.0627 0.0627
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0051 0.0095
Onchocerca volvulus 0.0032 0.0231 0.0426
Schistosoma mansoni retinoid-x-receptor (RXR) 0.011 0.1115 0.2239
Loa Loa (eye worm) hypothetical protein 0.0035 0.0264 0.0488
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0076 0.0419
Trichomonas vaginalis esterase, putative 0.0035 0.0264 0.035
Onchocerca volvulus 0.0063 0.0577 0.1066
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0018 0.0079 0.472
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0973 0.168
Onchocerca volvulus 0.0056 0.0502 0.0927
Schistosoma mansoni survival motor neuron protein 0.01 0.0999 0.2006
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0264 0.2417
Loa Loa (eye worm) hypothetical protein 0.0063 0.0577 0.1069
Schistosoma mansoni single-minded 0.0101 0.1009 0.2025
Schistosoma mansoni aryl hydrocarbon receptor 0.0101 0.1009 0.2025
Brugia malayi Cytochrome P450 family protein 0.0015 0.0037 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-14 0.011 0.1115 0.2066
Echinococcus multilocularis lamin dm0 0.0056 0.0502 0.0502
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.011 0.1115 0.2066
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0259 0.2794 0.5176
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.042 0.0643
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0974 0.1956
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0113 0.0808
Schistosoma mansoni elf1 0.0012 0.0003 0.0006
Schistosoma mansoni hypothetical protein 0.0055 0.0494 0.0992
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0003 0.0006
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0483 0.0895
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0973 0.168
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0113 0.0209
Brugia malayi orphan nuclear receptor NR2E1 0.0052 0.0458 0.0849
Echinococcus granulosus Nuclear hormone receptor HR96 0.0052 0.0458 0.0849
Echinococcus granulosus nuclear receptor nhr 48 0.0052 0.0458 0.0849
Echinococcus multilocularis musashi 0.0056 0.0502 0.0502
Schistosoma mansoni cpg binding protein 0.0032 0.0231 0.0463
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0264 0.4565
Loa Loa (eye worm) hypothetical protein 0.0052 0.0458 0.0849
Leishmania major hypothetical protein, conserved 0.0024 0.0146 0.1163
Echinococcus granulosus ETS transcription factor Elf 5 0.0012 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0067 0.0627 0.1161
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0052 0.0458 0.0849
Loa Loa (eye worm) ShTK domain-containing protein 0.0293 0.3175 0.5882
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0026 0.0167 0.031
Schistosoma mansoni kinase 0.005 0.0434 0.0872
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0076 0.5
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.014 0.1444 0.2675
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0026 0.0167 0.0167
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0113 0.0068
Mycobacterium ulcerans lipase LipD 0.0035 0.0264 0.0775
Brugia malayi hypothetical protein 0.0058 0.0529 0.0979
Echinococcus multilocularis ETS transcription factor Elf 5 0.0012 0.0003 0.0003
Mycobacterium ulcerans putative regulatory protein 0.0075 0.0713 0.2314
Loa Loa (eye worm) nuclear hormone receptor 0.0052 0.0458 0.0849
Echinococcus granulosus dnaJ subfamily B 0.0454 0.4981 0.9226
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0018 0.0079 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-25 0.011 0.1115 0.2066
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0006
Onchocerca volvulus 0.0056 0.0502 0.0927
Loa Loa (eye worm) CYP4Cod1 0.0033 0.0242 0.0448
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0577 0.929
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.0242 0.2187
Giardia lamblia Kinase, PLK 0.0098 0.0973 1
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0259 0.2786 0.5161
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0974 0.1956
Mycobacterium tuberculosis Probable oxidoreductase 0.0274 0.2959 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.011 0.1115 0.2066
Trypanosoma brucei unspecified product 0.0021 0.0113 0.0808
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0076 0.0142
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0974 0.1804
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0658 0.1322
Loa Loa (eye worm) fli-1 protein 0.0244 0.2618 0.485
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0209 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-25 0.011 0.1115 0.2066
Leishmania major DNA polymerase eta, putative 0.0021 0.0113 0.0808
Brugia malayi Steroid receptor seven-up type 2 0.011 0.1115 0.2066
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.2375 0.7999
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0043 0.008
Loa Loa (eye worm) hypothetical protein 0.0052 0.0458 0.0849
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0043 0.008
Brugia malayi hypothetical protein 0.0052 0.0458 0.0849
Trypanosoma brucei unspecified product 0.0015 0.0038 0.0009
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0051 0.0095
Loa Loa (eye worm) hypothetical protein 0.0091 0.0902 0.1671
Entamoeba histolytica hypothetical protein 0.0109 0.1104 1
Brugia malayi Cytochrome P450 family protein 0.0033 0.0242 0.0448
Loa Loa (eye worm) hypothetical protein 0.011 0.1115 0.2066
Schistosoma mansoni intermediate filament proteins 0.0056 0.0502 0.1008
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0113 0.0113
Brugia malayi Fli-1 protein 0.0244 0.2618 0.485
Schistosoma mansoni nuclear hormone receptor 0.011 0.1115 0.2239
Loa Loa (eye worm) hypothetical protein 0.0252 0.2706 0.5013
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0052 0.0458 0.092
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0026 0.0167 0.017
Loa Loa (eye worm) serotonin transporter b 0.0067 0.0627 0.1161
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0003 0.0006
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0018 0.0079 0.0143
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.011 0.1115 0.2066
Loa Loa (eye worm) ets-domain-containing protein 0.0012 0.0003 0.0006
Brugia malayi nuclear hormone receptor 0.011 0.1115 0.2066
Loa Loa (eye worm) hypothetical protein 0.0024 0.0146 0.0271
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0293 0.3175 0.5882
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0052 0.0458 0.0846
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0404 0.0614
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0058 0.0529 0.1062
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0293 0.3175 0.5882
Brugia malayi nuclear hormone receptor family member nhr-6 0.0052 0.0458 0.0849
Brugia malayi beta-lactamase 0.0035 0.0264 0.0488
Loa Loa (eye worm) hypothetical protein 0.0052 0.0462 0.0855
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0052 0.0458 0.0849
Entamoeba histolytica hypothetical protein 0.0109 0.1104 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0058 0.0529 0.0979
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0264 0.0264
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.0973 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0076 0.0419
Echinococcus multilocularis dna polymerase eta 0.0021 0.0113 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0113 0.0808
Loa Loa (eye worm) hypothetical protein 0.0052 0.0458 0.0849
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.0999 0.1851
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0058 0.0529 0.0529
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0012 0.0003 0.0006
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0076 0.0076
Echinococcus multilocularis GPCR, family 2 0.0015 0.0043 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0973 0.1954
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0264 0.0775
Brugia malayi Pre-SET motif family protein 0.0433 0.4744 0.8787
Loa Loa (eye worm) hypothetical protein 0.011 0.1115 0.2066
Echinococcus granulosus lamin 0.0056 0.0502 0.093
Brugia malayi hypothetical protein 0.0109 0.1104 0.2045
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0051 0.0095
Schistosoma mansoni hypothetical protein 0.0454 0.4981 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0113 0.0259
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0008 0.0016
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0051 0.0103
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.036 0.2758
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.011 0.1115 0.2239
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0176 0.1484
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0052 0.0458 0.0846
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0264 0.035
Schistosoma mansoni retinoic acid receptor RXR 0.011 0.1115 0.2239
Brugia malayi Cytochrome P450 family protein 0.0054 0.0483 0.0895
Echinococcus multilocularis jun protein 0.0259 0.2786 0.2786
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0264 0.035
Loa Loa (eye worm) cytochrome P450 0.0015 0.0037 0.0069
Echinococcus multilocularis ecdysone induced protein 78C 0.011 0.1115 0.1115
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0621 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0113 0.0808
Loa Loa (eye worm) steroid hormone receptor 0.011 0.1115 0.2066
Schistosoma mansoni hypothetical protein 0.0109 0.1104 0.2217
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0052 0.0458 0.0458
Schistosoma mansoni hypothetical protein 0.0033 0.0243 0.0487
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0052 0.0458 0.0458
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0146 0.253
Giardia lamblia DINP protein human, muc B family 0.0021 0.0113 0.0406
Onchocerca volvulus 0.0026 0.0167 0.0309
Brugia malayi beta-lactamase family protein 0.0035 0.0264 0.0488
Brugia malayi Nuclear hormone receptor family member nhr-19 0.011 0.1115 0.2066
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0176 0.0326
Plasmodium vivax SET domain protein, putative 0.0063 0.0577 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0164 0.0305
Echinococcus multilocularis protein C ets 2 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0067 0.0627 0.1161
Mycobacterium leprae Probable lipase LipE 0.0035 0.0264 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0092 0.0911 0.1688
Loa Loa (eye worm) hypothetical protein 0.0021 0.0113 0.0209
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0058 0.0529 0.1062
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.036 0.3159
Echinococcus granulosus nuclear receptor 2DBD gamma 0.011 0.1115 0.2066
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0076 0.0142
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0142
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0067 0.0627 0.1161
Onchocerca volvulus 0.0293 0.3175 0.5862
Loa Loa (eye worm) hypothetical protein 0.0055 0.0491 0.0909
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.008 0.0776 0.1438
Loa Loa (eye worm) hypothetical protein 0.0052 0.0462 0.0855
Echinococcus granulosus survival motor neuron protein 1 0.0491 0.5398 1
Echinococcus granulosus ETS domain containing protein Elk 1 0.0012 0.0003 0.0006
Brugia malayi tailless protein 0.0052 0.0458 0.0849
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0502 0.093
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0264 0.0488
Loa Loa (eye worm) hypothetical protein 0.0026 0.0164 0.0305
Brugia malayi Nuclear hormone receptor-like 1 0.011 0.1115 0.2066
Entamoeba histolytica hypothetical protein 0.0092 0.0911 0.8123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.011 0.1115 0.2066
Brugia malayi bHLH-PAS transcription factor 0.0075 0.0713 0.1321
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.1104 0.2217
Loa Loa (eye worm) norepinephrine transporter 0.0067 0.0627 0.1161
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0161 0.1682 0.1682
Loa Loa (eye worm) hypothetical protein 0.0035 0.0264 0.0488
Loa Loa (eye worm) hypothetical protein 0.0058 0.0529 0.0979
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0167 0.1389
Schistosoma mansoni hypothetical protein 0.021 0.224 0.4498
Loa Loa (eye worm) hypothetical protein 0.0339 0.3686 0.6828
Echinococcus multilocularis survival motor neuron protein 1 0.0491 0.5398 0.5398
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0577 0.0577
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0264 0.0775
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0167 0.017
Brugia malayi beta-lactamase family protein 0.0035 0.0264 0.0488
Echinococcus granulosus Ankyrin 0.0016 0.0053 0.0098
Brugia malayi Ets-domain containing protein 0.008 0.0776 0.1438
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.014 0.1444 0.1444
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0113 0.0808
Onchocerca volvulus Bile acid receptor homolog 0.011 0.1115 0.2059
Loa Loa (eye worm) ShTK domain-containing protein 0.0293 0.3175 0.5882
Echinococcus multilocularis pikachurin 0.0052 0.0462 0.0462
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0167 0.017
Echinococcus granulosus intermediate filament protein 0.0056 0.0502 0.093
Brugia malayi nuclear receptor NHR-88 0.011 0.1115 0.2066
Brugia malayi hypothetical protein 0.0491 0.5398 1
Schistosoma mansoni ets 0.0012 0.0003 0.0006
Onchocerca volvulus 0.0035 0.0264 0.0487
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0003 0.0003
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0176 0.1484
Onchocerca volvulus 0.0035 0.0264 0.0487
Onchocerca volvulus 0.0035 0.0264 0.0487
Schistosoma mansoni netrin receptor unc5 0.0016 0.0051 0.0103
Leishmania major DNA polymerase kappa, putative 0.0021 0.0113 0.0808
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0577 0.0577
Loa Loa (eye worm) hypothetical protein 0.0048 0.0414 0.0767
Schistosoma mansoni ets-related 0.0244 0.2618 0.5256
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0113 0.0354
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0095
Schistosoma mansoni slit 0.0052 0.0462 0.0927
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0264 0.0488
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0264 0.2417
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0973 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0577 0.1159
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0113 0.0259
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.011 0.1115 0.2239
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.011 0.1115 0.2066
Onchocerca volvulus 0.0293 0.3175 0.5862
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0973 0.168
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0167 0.017
Schistosoma mansoni sodium/chloride dependent transporter 0.0067 0.0627 0.1259
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0911 0.9335
Schistosoma mansoni coup transcription factor 0.011 0.1115 0.2239
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0242 0.0448
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0404 0.6504
Loa Loa (eye worm) hypothetical protein 0.0058 0.0529 0.0979
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0067 0.0627 0.1259
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0043 0.0043
Loa Loa (eye worm) solute carrier family 6 member 4 0.0067 0.0627 0.1161
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0033 0.0242 0.0701
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0458 0.0849
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0146 0.1163
Echinococcus granulosus GPCR family 2 0.0015 0.0043 0.008
Mycobacterium tuberculosis Conserved protein 0.0035 0.0264 0.0775
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0911 0.1829
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0167 0.017
Echinococcus granulosus retinoic acid receptor rxr beta a 0.011 0.1115 0.2066
Brugia malayi hypothetical protein 0.0016 0.0049 0.0091
Schistosoma mansoni hypothetical protein 0.014 0.1444 0.29
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0264 0.0775
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0404 0.0749
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0974 0.0974
Loa Loa (eye worm) hypothetical protein 0.0056 0.0502 0.093
Loa Loa (eye worm) hypothetical protein 0.0058 0.0529 0.0979
Mycobacterium tuberculosis Conserved protein 0.0035 0.0264 0.0775
Schistosoma mansoni hypothetical protein 0.01 0.0999 0.2006
Echinococcus multilocularis ewsr:fli fusion protein type 0.0012 0.0003 0.0003
Brugia malayi bZIP transcription factor family protein 0.0259 0.2786 0.5161
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0264 0.035
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0414 0.0767
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0051 0.0095
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0113 0.0808
Leishmania major protein kinase, putative 0.0027 0.0176 0.1484
Onchocerca volvulus 0.01 0.0999 0.1844
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0052 0.0462 0.0927
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0404 0.0614
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0092 0.0911 0.9335
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0577 0.1159
Brugia malayi DNA-binding protein D-ETS-3 0.0012 0.0003 0.0006
Brugia malayi Protein kinase domain containing protein 0.0092 0.0911 0.1688
Echinococcus multilocularis geminin 0.0352 0.3832 0.3832
Schistosoma mansoni nuclear receptor nhr-48 0.0052 0.0458 0.092
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0113 0.0808
Brugia malayi Common central domain of tyrosinase family protein 0.0293 0.3175 0.5882
Echinococcus multilocularis ETS transcription factor Elf 1 0.0012 0.0003 0.0003
Toxoplasma gondii ABC1 family protein 0.0035 0.0264 0.4241
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0146 0.406
Brugia malayi follicle stimulating hormone receptor 0.0259 0.2794 0.5176
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0973 0.168
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.011 0.1115 0.1115
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.0973 0.8729
Loa Loa (eye worm) hypothetical protein 0.0052 0.0458 0.0849
Brugia malayi intermediate filament protein 0.0056 0.0502 0.093
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.1104 0.2045
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0264 0.0488
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0076 0.0419
Mycobacterium ulcerans hypothetical protein 0.0035 0.0264 0.0775
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0974 0.1804
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0264 0.0775
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0293 0.3175 0.5882
Loa Loa (eye worm) hypoxia-induced factor 1 0.0312 0.3391 0.6281
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0974 0.1804
Loa Loa (eye worm) hypothetical protein 0.0067 0.0627 0.1161
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.011 0.1115 0.2066
Schistosoma mansoni jun-related protein 0.021 0.224 0.4498
Brugia malayi Ets-domain containing protein 0.0012 0.0003 0.0006
Echinococcus granulosus ewsr:fli fusion protein type 0.0012 0.0003 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0113 0.0808
Echinococcus granulosus dna polymerase kappa 0.0021 0.0113 0.0209
Schistosoma mansoni hypothetical protein 0.0352 0.3832 0.7694
Schistosoma mansoni tyrosinase precursor 0.0293 0.3175 0.6375
Schistosoma mansoni hypothetical protein 0.0015 0.0043 0.0087
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0259 0.2786 0.2786
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0038 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0974 0.1956
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.011 0.1115 0.2066
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0026 0.0167 0.1389
Echinococcus multilocularis Ankyrin 0.0016 0.0053 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0167 0.017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0264 0.0529
Schistosoma mansoni hypothetical protein 0.0352 0.3832 0.7694
Brugia malayi Pre-SET motif family protein 0.0063 0.0577 0.1069
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0076 0.1324
Loa Loa (eye worm) hypothetical protein 0.0035 0.0264 0.0488
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0113 0.0808
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0176 0.0176
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0008 0.0016
Mycobacterium ulcerans short chain dehydrogenase 0.0274 0.2959 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0113 0.0808
Echinococcus multilocularis FTZ F1 alpha 0.011 0.1115 0.1115
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0113 0.0808
Schistosoma mansoni Tr4/Tr2 (homologue) 0.011 0.1115 0.2239
Loa Loa (eye worm) hypothetical protein 0.011 0.1115 0.2066
Onchocerca volvulus 0.0492 0.5417 1
Echinococcus granulosus single minded 2 0.0075 0.0713 0.1321
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.011 0.1115 0.2059
Schistosoma mansoni lamin 0.0056 0.0502 0.1008
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0209 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-19 0.011 0.1115 0.2066
Brugia malayi Nuclear hormone receptor family member nhr-31 0.011 0.1115 0.2066
Echinococcus granulosus death domain containing protein 0.0016 0.0051 0.0095
Echinococcus multilocularis slit 2 protein 0.0052 0.0462 0.0462
Onchocerca volvulus Protein ultraspiracle homolog 0.011 0.1115 0.2059
Brugia malayi EGF-like domain containing protein 0.0052 0.0462 0.0855
Echinococcus granulosus dual specificity 0.0092 0.0911 0.1688
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0113 0.0808
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0012 0.0003 0.0006
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0051 0.0095
Loa Loa (eye worm) hypothetical protein 0.0052 0.0458 0.0849
Brugia malayi photoreceptor-specific nuclear receptor 0.011 0.1115 0.2066
Brugia malayi hypothetical protein 0.0052 0.0458 0.0849
Brugia malayi ShTK domain containing protein 0.0293 0.3175 0.5882
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0113 0.0808
Brugia malayi Nuclear hormone receptor family member nhr-40 0.011 0.1115 0.2066
Schistosoma mansoni nuclear receptor 0.0052 0.0458 0.092
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0264 0.0775
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.011 0.1115 0.2066
Brugia malayi Cytochrome P450 family protein 0.0033 0.0242 0.0448
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0146 0.2351
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0113 0.0808
Echinococcus granulosus Nuclear hormone receptor HR96 0.0052 0.0458 0.0849
Echinococcus granulosus aryl hydrocarbon receptor 0.0026 0.0167 0.031
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0026 0.0167 0.031
Onchocerca volvulus 0.0052 0.0458 0.0846
Schistosoma mansoni thyroid hormone receptor 0.025 0.2688 0.5396
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.011 0.1115 0.1115
Loa Loa (eye worm) DR-78 0.0052 0.0458 0.0849
Entamoeba histolytica protein kinase, putative 0.0092 0.0911 0.8123
Brugia malayi Nuclear hormone receptor E75 0.0052 0.0458 0.0849
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0161 0.1682 0.3377
Trichomonas vaginalis set domain proteins, putative 0.0492 0.5415 1
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0167 0.017
Onchocerca volvulus 0.011 0.1115 0.2059
Schistosoma mansoni ap endonuclease 0.0018 0.0076 0.0154
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0146 0.1163
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0092 0.0911 0.9335
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0433 0.4744 0.8787
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0113 0.0209
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0076 0.0134
Schistosoma mansoni ap endonuclease 0.0018 0.0076 0.0154
Onchocerca volvulus 0.0067 0.0627 0.1157
Loa Loa (eye worm) hypothetical protein 0.0052 0.0458 0.0849
Loa Loa (eye worm) hypothetical protein 0.0052 0.0458 0.0849
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0176 0.1484
Schistosoma mansoni ets-related 0.0012 0.0003 0.0006
Echinococcus multilocularis nmda type glutamate receptor 0.0026 0.016 0.016
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0404 0.6504
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0502 0.093
Brugia malayi hypothetical protein 0.0024 0.0146 0.0271
Brugia malayi Nuclear hormone receptor E75 0.0052 0.0458 0.0849
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0003 0.0003
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0007 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-49 0.011 0.1115 0.2066
Schistosoma mansoni zinc finger protein 0.0052 0.0458 0.092
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0043 0.008
Schistosoma mansoni cpg binding protein 0.0034 0.0251 0.0504
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.011 0.1115 0.2066
Brugia malayi Nuclear hormone receptor-like 1 0.0058 0.0529 0.0979
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.042 0.0643
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0026 0.0167 1
Schistosoma mansoni cell polarity protein 0.0052 0.0462 0.0927
Brugia malayi Nuclear hormone receptor family member nhr-3 0.011 0.1115 0.2066
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0043 0.008
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0458 0.092
Entamoeba histolytica hypothetical protein 0.0109 0.1104 1
Onchocerca volvulus 0.0293 0.3175 0.5862
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.011 0.1115 0.1115
Schistosoma mansoni nuclear receptor 0.0052 0.0458 0.092
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0264 0.0775
Loa Loa (eye worm) nuclear receptor NHR-67 0.0052 0.0458 0.0849
Loa Loa (eye worm) hypothetical protein 0.0052 0.0458 0.0849
Brugia malayi nuclear receptor NHR-88 0.0052 0.0458 0.0849
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.008
Loa Loa (eye worm) hypothetical protein 0.0058 0.0529 0.0979
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0293 0.3175 0.5882
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0577 0.1159
Loa Loa (eye worm) hypothetical protein 0.0035 0.0264 0.0488
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0012 0.0003 0.0003
Leishmania major hypothetical protein, conserved 0.0035 0.0264 0.2417
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0052 0.0458 0.0849
Echinococcus granulosus ecdysone induced protein 78C 0.011 0.1115 0.2066
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0076 0.0142
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0043 0.0043
Brugia malayi steroid hormone receptor 0.011 0.1115 0.2066
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0167 0.017
Trypanosoma brucei polo-like protein kinase 0.0098 0.0973 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0231 0.0427
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.011 0.1115 0.1115
Brugia malayi nuclear hormone receptor 0.0052 0.0458 0.0849
Echinococcus multilocularis aryl hydrocarbon receptor 0.0026 0.0167 0.0167
Loa Loa (eye worm) beta-lactamase 0.0035 0.0264 0.0488
Brugia malayi Death domain containing protein 0.0016 0.0051 0.0095
Onchocerca volvulus 0.0052 0.0458 0.0846
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0146 0.406
Onchocerca volvulus 0.0075 0.0713 0.1317
Schistosoma mansoni sodium/chloride dependent transporter 0.0012 0.0009 0.0018
Brugia malayi conserved hypotetical protein 0.0052 0.0458 0.0849
Brugia malayi hypothetical protein 0.0058 0.0529 0.0979
Mycobacterium ulcerans beta-lactamase 0.0035 0.0264 0.0775
Echinococcus multilocularis nuclear receptor nhr 48 0.0052 0.0458 0.0458
Brugia malayi nuclear hormone receptor family member odr-7 0.0052 0.0458 0.0849
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0113 0.0113
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0026 0.0167 0.017
Echinococcus granulosus cpg binding protein 0.0034 0.0251 0.0465
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0052 0.0458 0.0458
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0404 0.7001
Loa Loa (eye worm) hypothetical protein 0.0058 0.0529 0.0979
Loa Loa (eye worm) hypothetical protein 0.011 0.1115 0.2066
Schistosoma mansoni cpg binding protein 0.0034 0.0251 0.0504
Onchocerca volvulus 0.0203 0.216 0.3988
Echinococcus granulosus ETS transcription factor Elf 1 0.0012 0.0003 0.0006
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.1104 0.1104
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0052 0.0462 0.0855
Brugia malayi nuclear receptor RXR 0.0052 0.0458 0.0849
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0113 0.0808
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0113 0.0808
Loa Loa (eye worm) hypothetical protein 0.0035 0.0264 0.0488
Schistosoma mansoni hypothetical protein 0.0015 0.0043 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.011 0.1115 0.2066
Echinococcus multilocularis transfer RNA-Lys 0.0075 0.0713 0.0713
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.011 0.1115 0.2239
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.011 0.1115 0.1115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.011 0.1115 0.2066
Echinococcus granulosus neurogenic locus notch protein 0.0052 0.0462 0.0855
Echinococcus granulosus histone acetyltransferase KAT2B 0.0156 0.1631 0.3022
Entamoeba histolytica protein kinase, putative 0.0092 0.0911 0.8123
Brugia malayi Ets-domain containing protein 0.008 0.0776 0.1438
Loa Loa (eye worm) abnormal epIthelia family member 0.0052 0.0462 0.0855
Schistosoma mansoni DNA polymerase eta 0.0021 0.0113 0.0227
Brugia malayi cytochrome P450 0.0015 0.0037 0.0069
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0076 0.0134
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.011 0.1115 0.1115
Loa Loa (eye worm) hypothetical protein 0.0293 0.3175 0.5882
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0113 0.0209
Onchocerca volvulus 0.0293 0.3175 0.5862
Loa Loa (eye worm) hypothetical protein 0.0035 0.0264 0.0488
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0113 0.0227
Schistosoma mansoni steroid hormone receptor ad4bp 0.011 0.1115 0.2239
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0577 0.1159
Schistosoma mansoni hypothetical protein 0.0016 0.0051 0.0103
Loa Loa (eye worm) hypothetical protein 0.0293 0.3175 0.5882
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0053 0.0106
Loa Loa (eye worm) hypothetical protein 0.0069 0.0645 0.1195
Toxoplasma gondii exonuclease III APE 0.0018 0.0076 0.123
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0973 1
Brugia malayi ecdysteroid receptor 0.011 0.1115 0.2066
Brugia malayi PAS domain containing protein 0.0101 0.1009 0.1869
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.0973 0.1803
Loa Loa (eye worm) hypothetical protein 0.011 0.1115 0.2066
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.011 0.1115 0.2239
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.0242 0.2187
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.011 0.1115 0.2066
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0018 0.0079 0.0045
Loa Loa (eye worm) hypothetical protein 0.011 0.1115 0.2066
Loa Loa (eye worm) hypothetical protein 0.0052 0.0458 0.0849
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.0973 0.1803
Brugia malayi hypoxia-induced factor 1 0.0312 0.3391 0.6281
Brugia malayi ecdysone receptor 0.0052 0.0458 0.0849
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0113 0.0808
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0458 0.0458
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0006
Schistosoma mansoni hypothetical protein 0.0015 0.0037 0.0075
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0911 0.9335
Brugia malayi Nuclear hormone receptor family member nhr-41 0.011 0.1115 0.2066
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0974 0.0974
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0052 0.0458 0.0458
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0502 0.093
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0146 0.1163
Loa Loa (eye worm) hypothetical protein 0.0033 0.0243 0.0449
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0414 0.0767
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0264 0.0775
Mycobacterium leprae Possible regulatory protein 0.0026 0.0167 0.5746
Treponema pallidum sodium- and chloride- dependent transporter 0.0067 0.0627 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0113 0.0808
Echinococcus multilocularis GA binding protein alpha chain 0.008 0.0776 0.0776
Loa Loa (eye worm) D-ets-2 protein 0.0012 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0176 0.0326
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0043 0.008
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0167 0.017
Brugia malayi Nuclear hormone receptor-like 1 0.0058 0.0529 0.0979
Echinococcus multilocularis ets variant gene 4 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0052 0.0458 0.0849
Echinococcus multilocularis thyroid hormone receptor alpha 0.025 0.2688 0.2688
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0544 0.1007
Schistosoma mansoni RAR-like nuclear receptor 0.011 0.1115 0.2239
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0113 0.0227
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0076 0.2125
Echinococcus multilocularis lamin 0.0056 0.0502 0.0502
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0058 0.0529 0.0979
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0458 0.092
Trypanosoma brucei cytochrome P450, putative 0.0033 0.0242 0.2187
Echinococcus granulosus dna polymerase eta 0.0021 0.0113 0.0209
Brugia malayi hypothetical protein 0.0339 0.3686 0.6828
Chlamydia trachomatis glutamine binding protein 0.0018 0.0079 0.472
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0243 0.0449
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0113 0.0209
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.036 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0038 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0167 0.017
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0006
Echinococcus granulosus protein C ets 2 0.0012 0.0003 0.0006
Brugia malayi nuclear receptor NHR-67 0.0052 0.0458 0.0849
Loa Loa (eye worm) hypothetical protein 0.0052 0.0462 0.0855
Brugia malayi transcription factor E74 isoform 0.0012 0.0003 0.0006
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0577 0.1069
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0113 0.0259
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0264 0.2417
Brugia malayi acetyltransferase, GNAT family protein 0.0161 0.1682 0.3116
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0264 0.0775
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0008 0.0008
Echinococcus granulosus lamin dm0 0.0056 0.0502 0.093
Loa Loa (eye worm) tyrosinase 1 0.0293 0.3175 0.5882
Loa Loa (eye worm) hypothetical protein 0.0052 0.0458 0.0849
Trypanosoma brucei unspecified product 0.0015 0.0038 0.0009
Loa Loa (eye worm) acetyltransferase 0.0161 0.1682 0.3116

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 1000 uM Growth inhibition of Candida albicans JRW#5 ChEMBL. 17079152
IC50 (functional) > 1000 uM Growth inhibition of Candida albicans JRW#5 ChEMBL. 17079152

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.