Detailed information for compound 42538

Basic information

Technical information
  • TDR Targets ID: 42538
  • Name: (3R,4R)-3-amino-1-hydroxy-4-methylpyrrolidin- 2-one
  • MW: 130.145 | Formula: C5H10N2O2
  • H donors: 2 H acceptors: 2 LogP: -1.07 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H]1CN(C(=O)[C@@H]1N)O
  • InChi: 1S/C5H10N2O2/c1-3-2-7(9)5(8)4(3)6/h3-4,9H,2,6H2,1H3/t3-,4-/m1/s1
  • InChiKey: SKYSFPFYQBZGDC-QWWZWVQMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3R,4R)-3-amino-1-hydroxy-4-methyl-pyrrolidin-2-one
  • (3R,4R)-3-amino-1-hydroxy-4-methyl-2-pyrrolidinone
  • (3R,4R)-3-azanyl-1-hydroxy-4-methyl-pyrrolidin-2-one
  • (3R,4R)-3-amino-1-hydroxy-4-methyl-2-pyrrolidone
  • L 687414

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Glutamate NMDA receptor References
Rattus norvegicus Glutamate [NMDA] receptor subunit epsilon 3 Starlite/ChEMBL References
Rattus norvegicus Glutamate (NMDA) receptor subunit zeta 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus glutamate NMDA receptor subunit Get druggable targets OG5_129290 All targets in OG5_129290
Echinococcus multilocularis glutamate (NMDA) receptor subunit Get druggable targets OG5_129290 All targets in OG5_129290
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum expressed protein Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum ko:K05314 glutamate receptor, ionotropic, N-methyl-D-aspartate 2, invertebrate, putative Get druggable targets OG5_129290 All targets in OG5_129290
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma mansoni glutamate receptor NMDA Get druggable targets OG5_129290 All targets in OG5_129290
Echinococcus multilocularis nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma mansoni glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Drosophila melanogaster NMDA receptor 2 Glutamate (NMDA) receptor subunit zeta 1   938 aa 878 aa 27.4 %
Echinococcus multilocularis glutamate (NMDA) receptor subunit Glutamate (NMDA) receptor subunit zeta 1   938 aa 822 aa 23.2 %
Drosophila melanogaster Glutamate receptor IA Glutamate (NMDA) receptor subunit zeta 1   938 aa 979 aa 23.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0023 0.0166 0.0586
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0112 0.0225
Toxoplasma gondii exonuclease III APE 0.0039 0.0363 0.1662
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0102 0.0102
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0266 0.3202 0.3202
Plasmodium falciparum nitric oxide synthase, putative 0.0079 0.0856 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0102 0.0395
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0119 0.0165
Onchocerca volvulus 0.0014 0.0052 0.0183
Brugia malayi Fli-1 protein 0.0217 0.2587 1
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0002 0.0003
Onchocerca volvulus 0.0014 0.0045 0.0159
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0002 0.0005
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0102 0.0142
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0102 0.0205
Echinococcus multilocularis pikachurin 0.0024 0.0175 0.0175
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0084 0.0117
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0112 0.0225
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0129 0.1483 0.2976
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0166 0.0166
Echinococcus granulosus aminopeptidase N 0.0012 0.0027 0.0038
Schistosoma mansoni neuropeptide receptor 0.0023 0.0166 0.0334
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Brugia malayi transcription factor E74 isoform 0.001 0.0002 0.001
Schistosoma mansoni NADPH flavin oxidoreductase 0.004 0.0368 0.0739
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0027 0.0124
Loa Loa (eye worm) hypothetical protein 0.0051 0.0512 0.1335
Echinococcus granulosus bloom syndrome protein 0.002 0.012 0.0167
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0011 0.0009 0.0031
Brugia malayi putative neuropeptide receptor 0.0023 0.0166 0.0643
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0135
Trichomonas vaginalis sulfite reductase, putative 0.0079 0.0856 0.3016
Onchocerca volvulus 0.0015 0.0063 0.0221
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0084 0.0297
Schistosoma mansoni DNA helicase recq5 0.002 0.012 0.0242
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0052 0.0237
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0166 0.0434
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.4981 0.4981
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0102 0.0395
Trypanosoma brucei Aminopeptidase M1, putative 0.0012 0.0027 0.0316
Schistosoma mansoni hypothetical protein 0.0409 0.4981 1
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0166 0.0334
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0185 0.2185 1
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.012 0.0424
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0166 0.0231
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0102 0.0142
Onchocerca volvulus 0.0023 0.0166 0.0586
Brugia malayi RE15519p 0.0023 0.0166 0.0643
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.1128 0.2264
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0562 0.0562
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0231 0.0604
Echinococcus multilocularis neuropeptide s receptor 0.0023 0.0166 0.0166
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0027 0.0105
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.1128 0.2264
Leishmania major cytochrome P450 reductase, putative 0.007 0.0744 0.3407
Echinococcus multilocularis glutamate receptor NMDA 0.0095 0.1063 0.1063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0321 0.0838
Onchocerca volvulus 0.0237 0.2839 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Toxoplasma gondii kringle domain-containing protein 0.0022 0.015 0.0685
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Schistosoma mansoni cpg binding protein 0.0029 0.0231 0.0465
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0002 0.0006
Trichomonas vaginalis NADPH cytochrome P450, putative 0.003 0.0249 0.0877
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0166 0.0231
Brugia malayi AKH receptor 0.0023 0.0166 0.0643
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0084 0.0169
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Entamoeba histolytica aminopeptidase, putative 0.0012 0.0027 0.054
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0341 0.0341
Onchocerca volvulus 0.0023 0.0166 0.0586
Loa Loa (eye worm) hypothetical protein 0.0024 0.0175 0.0457
Echinococcus multilocularis RUN 0.002 0.0119 0.0119
Schistosoma mansoni nAChR subunit 0.0018 0.0102 0.0205
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0063 0.0243
Brugia malayi hypothetical protein 0.002 0.0119 0.046
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0079 0.0856 1
Brugia malayi hypothetical protein 0.0023 0.0166 0.0643
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Toxoplasma gondii aminopeptidase N, putative 0.0012 0.0027 0.0124
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0063 0.0087
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0118
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0102 0.0102
Echinococcus multilocularis neuropeptide receptor A26 0.0023 0.0166 0.0166
Schistosoma mansoni thyroid hormone receptor 0.0293 0.3531 0.709
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0002 0.0002
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0112 0.0293
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0164
Echinococcus granulosus g protein coupled receptor 0.0023 0.0166 0.0231
Entamoeba histolytica cell division protein kinase 2, putative 0.005 0.0501 1
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0011 0.0009 0.0023
Toxoplasma gondii hypothetical protein 0.0014 0.0052 0.0237
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0102 0.0102
Schistosoma mansoni nAChR subunit 0.0018 0.0102 0.0205
Echinococcus multilocularis nmda type glutamate receptor 0.0109 0.1235 0.1235
Loa Loa (eye worm) hypothetical protein 0.0051 0.0516 0.1346
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0135
Loa Loa (eye worm) hypothetical protein 0.01 0.1128 0.2941
Echinococcus multilocularis expressed protein 0.0033 0.029 0.029
Schistosoma mansoni nAChR subunit 0.0018 0.0102 0.0205
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0084 0.0326
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0199 0.0199
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0102 0.0395
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0023 0.0166 0.0643
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0102 0.0205
Schistosoma mansoni thyroid hormone receptor 0.0293 0.3531 0.709
Brugia malayi von Willebrand factor type A domain containing protein 0.0011 0.0009 0.0034
Toxoplasma gondii aminopeptidase n, putative 0.0012 0.0027 0.0124
Brugia malayi flavodoxin family protein 0.0079 0.0856 0.3309
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.028 0.3272
Schistosoma mansoni lamin 0.0054 0.0549 0.1102
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.003 0.0249 0.2908
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0135
Brugia malayi FAD binding domain containing protein 0.0079 0.0856 0.3309
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0185 0.2185 0.2185
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0027 0.0027
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0002 0.0003
Schistosoma mansoni cytochrome P450 reductase 0.0079 0.0856 0.1719
Trypanosoma brucei cdc2-related kinase 3 0.005 0.0501 0.5858
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.005 0.0501 0.1308
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0112 0.0156
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0071
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0002 0.0002
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0084 0.0326
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.005 0.0501 0.2296
Brugia malayi Guanylyl cyclase protein 23 0.0014 0.0045 0.0175
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0321 0.1132
Echinococcus granulosus methionine synthase reductase 0.0049 0.048 0.0667
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0321 0.1242
Schistosoma mansoni tyrosine kinase 0.0014 0.0045 0.0091
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0166 0.0166
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0084 0.0169
Entamoeba histolytica hypothetical protein, conserved 0.0011 0.0009 0.0174
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0063 0.0087
Leishmania major hypothetical protein, conserved 0.003 0.0249 0.1139
Schistosoma mansoni lipoxygenase 0.0055 0.0562 0.1129
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0286
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0125 0.0252
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0112 0.0434
Toxoplasma gondii aminopeptidase N protein 0.0012 0.0027 0.0124
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Brugia malayi hypothetical protein 0.0019 0.011 0.0424
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0102 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0321 0.1242
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0102 0.0102
Onchocerca volvulus 0.0029 0.0231 0.0815
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0566 0.2591
Brugia malayi nuclear receptor RXR 0.0017 0.0084 0.0326
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.2185 1
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0012 0.0027 0.0216
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0079 0.0856 1
Loa Loa (eye worm) hypothetical protein 0.01 0.1128 0.2941
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0112 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0321 0.1242
Entamoeba histolytica hypothetical protein 0.0019 0.0112 0.2237
Schistosoma mansoni ap endonuclease 0.0039 0.0363 0.0729
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0166 0.0166
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0076 0.0153
Schistosoma mansoni hypothetical protein 0.0257 0.3083 0.6189
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0079 0.0856 1
Giardia lamblia Kinase, CMGC CDK 0.005 0.0501 0.6738
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0164
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.2185 1
Schistosoma mansoni ap endonuclease 0.0039 0.0363 0.0729
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0011 0.0009 0.0009
Chlamydia trachomatis sulfite reductase 0.0049 0.048 0.6209
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0166 0.0334
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0512 0.598
Loa Loa (eye worm) norepinephrine transporter 0.0015 0.0063 0.0164
Schistosoma mansoni cpg binding protein 0.003 0.0252 0.0506
Schistosoma mansoni elf1 0.001 0.0002 0.0005
Brugia malayi hypothetical protein 0.0019 0.0112 0.0434
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.0175 0.0244
Brugia malayi metabotropic glutamate receptor type 2 0.0014 0.0045 0.0175
Echinococcus granulosus voltage dependent calcium channel subunit 0.0586 0.7193 1
Entamoeba histolytica hypothetical protein 0.0019 0.0112 0.2237
Brugia malayi TATA binding protein associated factor 0.0012 0.0027 0.0105
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0166 0.0334
Onchocerca volvulus 0.0023 0.0166 0.0586
Brugia malayi hypothetical protein 0.0023 0.0166 0.0643
Brugia malayi Glutamate receptor 2 precursor 0.0027 0.0209 0.0808
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0061 0.0637 0.1662
Loa Loa (eye worm) TYRA-2 protein 0.0023 0.0166 0.0434
Schistosoma mansoni amine GPCR 0.0023 0.0166 0.0334
Brugia malayi PAN domain containing protein 0.0014 0.0052 0.0201
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0027 0.0038
Brugia malayi hypothetical protein 0.0014 0.0045 0.0175
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0063 0.0126
Entamoeba histolytica hypothetical protein 0.0037 0.0341 0.6796
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0084 0.0169
Trichomonas vaginalis rotamase, putative 0.0033 0.028 0.0987
Schistosoma mansoni hypothetical protein 0.0023 0.0159 0.032
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0063 0.0164
Loa Loa (eye worm) hypothetical protein 0.0022 0.015 0.039
Echinococcus multilocularis musashi 0.0054 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Onchocerca volvulus 0.0014 0.0045 0.0159
Loa Loa (eye worm) hypothetical protein 0.0036 0.0321 0.0838
Brugia malayi nuclear receptor NHR-88 0.0036 0.0321 0.1242
Schistosoma mansoni histamine h1 receptor 0.0023 0.0166 0.0334
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0027 0.0105
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0041 0.0381 0.0381
Trypanosoma brucei Aminopeptidase M1, putative 0.0012 0.0027 0.0316
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0011 0.0009 0.0034
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0112 0.0156
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0063 0.0288
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0321 0.0447
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0166 0.0166
Schistosoma mansoni ets-related 0.0217 0.2587 0.5194
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0112 0.0293
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0052 0.0237
Trypanosoma cruzi aminopeptidase, putative 0.0012 0.0027 0.0316
Echinococcus granulosus fmrfamide receptor 0.0023 0.0166 0.0231
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0023 0.0166 0.0231
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0002 0.0003
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0084 0.0326
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0023 0.0166 0.0434
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.012 0.0314
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0125 0.0327
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Onchocerca volvulus 0.0015 0.0063 0.0221
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0159 0.0222
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0166 0.0231
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0321 0.0838
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0002 0.0003
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0063 0.0126
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0102 0.0142
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0102 0.0142
Brugia malayi von Willebrand factor type A domain containing protein 0.0011 0.0009 0.0034
Brugia malayi laminin alpha chain 0.0024 0.0175 0.0677
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0321 0.0838
Loa Loa (eye worm) hypothetical protein 0.0026 0.0199 0.0519
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0112 0.0225
Onchocerca volvulus 0.0023 0.0166 0.0586
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0012 0.0027 0.0216
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0102 0.0102
Loa Loa (eye worm) FAD binding domain-containing protein 0.0079 0.0856 0.2232
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0079 0.0856 0.3919
Brugia malayi G protein-coupled receptor F59B2.13 0.0023 0.0166 0.0643
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0166 0.0166
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0023 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0027 0.0027
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0014 0.0045 0.0045
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.01 0.1128 0.1128
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0024 0.0175 0.0352
Trypanosoma cruzi Aminopeptidase M1, putative 0.0012 0.0027 0.0316
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0023 0.0166 0.0434
Brugia malayi nuclear hormone receptor 0.0017 0.0084 0.0326
Onchocerca volvulus 0.0014 0.0052 0.0183
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0084 0.0326
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0321 0.0645
Echinococcus multilocularis neuropeptide FF receptor 2 0.0023 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0586 0.7193 0.7193
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0023 0.0166 0.0166
Schistosoma mansoni opsin-like receptor 0.0023 0.0166 0.0334
Brugia malayi neuropeptide F receptor 0.0023 0.0166 0.0643
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0063 0.0243
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0063 0.0288
Toxoplasma gondii subtilisin SUB12 0.0014 0.0052 0.0237
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0063 0.0164
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0112 0.0156
Echinococcus multilocularis thyroid hormone receptor alpha 0.0293 0.3531 0.3531
Entamoeba histolytica hypothetical protein 0.0037 0.0341 0.6796
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0166 0.0231
Schistosoma mansoni neuropeptide receptor 0.0023 0.0166 0.0334
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0112 0.0112
Schistosoma mansoni nuclear receptor 0.0017 0.0084 0.0169
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0321 0.0645
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0166 0.0334
Echinococcus granulosus peptide allatostatin:somatostatin 0.0023 0.0166 0.0231
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0112 0.0434
Loa Loa (eye worm) glutamate receptor 0.0014 0.0045 0.0118
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0102 0.0205
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0012 0.0027 0.0316
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0063 0.0243
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0084 0.0084
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0102 0.0102
Schistosoma mansoni lamin 0.0054 0.0549 0.1102
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.003 0.0249 0.2908
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0166 0.0166
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.012 0.0424
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Schistosoma mansoni loxhd1 0.002 0.0119 0.0239
Brugia malayi Receptor family ligand binding region containing protein 0.0014 0.0045 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0321 0.1242
Brugia malayi cell division control protein 2 homolog 0.005 0.0501 0.1938
Echinococcus granulosus g-protein coupled receptor 0.0023 0.0166 0.0231
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0112 0.0225
Schistosoma mansoni DNA helicase recq1 0.002 0.012 0.0242
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0052 0.0135
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0321 0.1242
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0102 0.0205
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0232 0.2777 0.2777
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0112 0.0225
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0166 0.0334
Echinococcus granulosus glutamate receptor NMDA 0.0095 0.1063 0.1478
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0102 0.0102
Brugia malayi hypothetical protein 0.0051 0.0512 0.1979
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0014 0.0052 0.0237
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0166 0.0334
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.029 0.1021
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0084 0.0326
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0512 0.5938
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0166 0.0231
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0321 0.0447
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0112 0.0395
Echinococcus granulosus nmda type glutamate receptor 0.0109 0.1235 0.1717
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0023 0.0166 0.0334
Onchocerca volvulus 0.0023 0.0166 0.0586
Loa Loa (eye worm) hypothetical protein 0.0024 0.0175 0.0457
Loa Loa (eye worm) DR-78 0.0017 0.0084 0.022
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0002 0.0003
Brugia malayi Glutamate receptor 1 precursor 0.0027 0.0209 0.0808
Schistosoma mansoni glutamate receptor NMDA 0.0094 0.1042 0.2092
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0084 0.0326
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0166 0.0166
Onchocerca volvulus 0.0018 0.0102 0.036
Onchocerca volvulus 0.0017 0.0084 0.0297
Plasmodium falciparum protein kinase 5 0.005 0.0501 0.5815
Brugia malayi Zona pellucida-like domain containing protein 0.0011 0.0009 0.0034
Brugia malayi Cation transporter family protein 0.0018 0.0102 0.0395
Brugia malayi Serotonin receptor 0.0023 0.0166 0.0643
Echinococcus granulosus alpha 1A adrenergic receptor 0.0023 0.0166 0.0231
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0002 0.0002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0102 0.0395
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus multilocularis tumor protein p63 0.0352 0.4269 0.4269
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Loa Loa (eye worm) glutamate receptor 2 0.0027 0.0209 0.0545
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0341 0.0684
Echinococcus multilocularis cpg binding protein 0.003 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Onchocerca volvulus 0.0011 0.0009 0.0031
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0002 0.0002
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0027 0.0124
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0084 0.022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Brugia malayi hypothetical protein 0.0012 0.0027 0.0105
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0045 0.0118
Trypanosoma cruzi cdc2-related kinase 3 0.005 0.0501 0.5858
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0166 0.0166
Onchocerca volvulus Neuropeptide F receptor homolog 0.0023 0.0166 0.0586
Mycobacterium ulcerans aminopeptidase N PepN 0.0012 0.0027 0.0124
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0063 0.0243
Brugia malayi von Willebrand factor type A domain containing protein 0.0011 0.0009 0.0034
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0166 0.0231
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Schistosoma mansoni neuropeptide f receptor 76f 0.0023 0.0166 0.0334
Schistosoma mansoni nAChR subunit 0.0018 0.0102 0.0205
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0512 0.2343
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0112 0.0434
Trypanosoma cruzi cdc2-related kinase 1 0.005 0.0501 0.5858
Brugia malayi FAD binding domain containing protein 0.0049 0.048 0.1855
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Brugia malayi laminin-like protein K08C7.3 precursor 0.0024 0.0175 0.0677
Trichomonas vaginalis NADPH cytochrome P450, putative 0.003 0.0249 0.0877
Brugia malayi von Willebrand factor type A domain containing protein 0.0011 0.0009 0.0034
Brugia malayi Cytochrome P450 family protein 0.0023 0.0157 0.0608
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0125 0.0252
Echinococcus multilocularis serotonin transporter 0.0015 0.0063 0.0063
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0321 0.0447
Echinococcus multilocularis cyclin dependent kinase 5 0.005 0.0501 0.0501
Entamoeba histolytica type A flavoprotein, putative 0.003 0.0249 0.4964
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Plasmodium vivax hypothetical protein, conserved 0.003 0.0249 0.2835
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0023 0.0166 0.0643
Brugia malayi hypothetical protein 0.0033 0.0285 0.1103
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0112 0.0395
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0102 0.0395
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0014 0.0045 0.0159
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.012 0.012
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.003 0.0249 0.2835
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0166 0.0166
Brugia malayi Protein kinase domain containing protein 0.0022 0.015 0.0579
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0023 0.0166 0.0643
Echinococcus multilocularis G-protein coupled receptor, putative 0.0023 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0118
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0767 0.1066
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0041 0.0381 0.0381
Brugia malayi Doublecortin family protein 0.002 0.0119 0.046
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0112 0.0112
Onchocerca volvulus 0.0023 0.0166 0.0586
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0023 0.0166 0.0643
Schistosoma mansoni sodium-dependent amino acid transporter 0.0015 0.0063 0.0126
Brugia malayi hypothetical protein 0.0023 0.0166 0.0643
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0164
Loa Loa (eye worm) CUTiclin family member 0.0011 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0321 0.0321
Entamoeba histolytica cell division protein kinase 2, putative 0.005 0.0501 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0027 0.0105
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0112 0.0112
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0027 0.0038
Loa Loa (eye worm) fli-1 protein 0.0217 0.2587 0.6747
Leishmania major p450 reductase, putative 0.0079 0.0856 0.3919
Toxoplasma gondii microneme protein MIC2 0.0011 0.0009 0.004
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.011 0.022
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0063 0.0126
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0023 0.0166 0.0334
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0185 0.2185 1
Echinococcus granulosus intermediate filament protein 0.0054 0.0549 0.0763
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0118
Echinococcus multilocularis tyrosine kinase 0.0014 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0019 0.0112 0.0293
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Plasmodium vivax flavodoxin domain containing protein 0.007 0.0744 0.8681
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0063 0.0126
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0341 0.0474
Brugia malayi intermediate filament protein 0.0054 0.0549 0.2121
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.0175 0.0352
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0079 0.0856 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0084 0.0084
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0321 0.0321
Brugia malayi steroid hormone receptor 0.0036 0.0321 0.1242
Brugia malayi von Willebrand Factor 0.0011 0.0009 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0166 0.0334
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.003 0.0249 0.2908
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0006
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0102 0.0142
Brugia malayi Cation transporter family protein 0.0018 0.0102 0.0395
Schistosoma mansoni glutamate receptor kainate 0.0027 0.0209 0.042
Schistosoma mansoni zinc finger protein 0.0017 0.0084 0.0169
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0084 0.0117
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0102 0.0205
Schistosoma mansoni regulator of G protein signaling 0.0021 0.013 0.026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0321 0.0645
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Trypanosoma cruzi aminopeptidase, putative 0.0012 0.0027 0.0316
Entamoeba histolytica elongation factor-2 kinase, putative 0.0011 0.0009 0.0174
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0253 0.116
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0363 0.4182
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0112 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0321 0.1242
Brugia malayi hypothetical protein 0.0023 0.0166 0.0643
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Brugia malayi Dopamine receptor protein 2 0.0023 0.0166 0.0643
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0166 0.0334
Echinococcus granulosus dro:myosuppressin receptor 0.0023 0.0166 0.0231
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0501 0.1308
Schistosoma mansoni tyrosine kinase 0.0014 0.0045 0.0091
Brugia malayi hypothetical protein 0.0019 0.0112 0.0434
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0321 0.1242
Onchocerca volvulus 0.0014 0.0052 0.0183
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0023 0.0166 0.0334
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Echinococcus granulosus glutamate NMDA receptor subunit 0.0094 0.1042 0.1449
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0516 0.1036
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0023 0.0166 0.0334
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0321 0.1242
Schistosoma mansoni diflavin oxidoreductase 0.0039 0.0361 0.0724
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0321 0.1242
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0253 0.0509
Brugia malayi Ets-domain containing protein 0.0072 0.0767 0.2964
Onchocerca volvulus 0.002 0.0119 0.0419
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0102 0.0395
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0501 0.1766
Brugia malayi PAN domain containing protein 0.0014 0.0052 0.0201
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0023 0.0166 0.0334
Schistosoma mansoni glutamate receptor kainate 0.0027 0.0209 0.042
Schistosoma mansoni hypothetical protein 0.001 0.0002 0.0005
Onchocerca volvulus 0.0015 0.0063 0.0221
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0166 0.0334
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0363 0.1662
Echinococcus granulosus 7tm_1 domain containing protein 0.0023 0.0166 0.0231
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0767 0.2
Echinococcus multilocularis cyclin dependent kinase 0.005 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0112 0.0395
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0084 0.0084
Onchocerca volvulus 0.0014 0.0052 0.0183
Echinococcus granulosus slit 2 protein 0.0024 0.0175 0.0244
Brugia malayi PAN domain containing protein 0.0014 0.0052 0.0201
Echinococcus multilocularis ets variant gene 4 0.001 0.0002 0.0002
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0084 0.0297
Brugia malayi von Willebrand factor type A domain containing protein 0.0011 0.0009 0.0034
Brugia malayi Pre-SET motif family protein 0.003 0.0253 0.098
Onchocerca volvulus 0.0023 0.0166 0.0586
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0166 0.0231
Schistosoma mansoni amine GPCR 0.0023 0.0166 0.0334
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0102 0.0395
Echinococcus multilocularis NMDA receptor 0.0027 0.0209 0.0209
Schistosoma mansoni serine-rich repeat protein 0.0138 0.1592 0.3197
Plasmodium vivax protein kinase Crk2 0.005 0.0501 0.5815
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0363 0.1279
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0002 0.0002
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0102 0.0266
Echinococcus granulosus lamin dm0 0.0054 0.0549 0.0763
Brugia malayi hypothetical protein 0.0011 0.0009 0.0034
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0119 0.0119
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.0175 0.0175
Onchocerca volvulus 0.0014 0.0052 0.0183
Brugia malayi von Willebrand factor type A domain containing protein 0.0011 0.0009 0.0034
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.011 0.0424
Onchocerca volvulus 0.0054 0.0549 0.1933
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0321 0.0645
Brugia malayi nuclear hormone receptor 0.0036 0.0321 0.1242
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0166 0.0334
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0512 0.598
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0321 0.0645
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0166 0.0334
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0071
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.003 0.0249 0.2835
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0023 0.0166 0.0166
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0052 0.0237
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0069 0.0735 0.1104
Mycobacterium ulcerans aldehyde dehydrogenase 0.0185 0.2185 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.031
Entamoeba histolytica type A flavoprotein, putative 0.003 0.0249 0.4964
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0079 0.0856 0.119
Schistosoma mansoni opsin-like receptor 0.0023 0.0166 0.0334
Onchocerca volvulus 0.0023 0.0166 0.0586
Schistosoma mansoni nAChR subunit 0.0018 0.0102 0.0205
Onchocerca volvulus 0.0014 0.0052 0.0183
Leishmania major hypothetical protein, conserved 0.0051 0.0512 0.2343
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0063 0.0126
Onchocerca volvulus 0.0018 0.0102 0.036
Echinococcus granulosus neuropeptide s receptor 0.0023 0.0166 0.0231
Schistosoma mansoni biogenic amine receptor 0.0023 0.0166 0.0334
Onchocerca volvulus 0.0011 0.0009 0.0031
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0112 0.0112
Loa Loa (eye worm) TATA binding protein associated factor 0.0012 0.0027 0.0071
Brugia malayi neuropeptide F receptor 0.0023 0.0166 0.0643
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0023 0.0166 0.0231
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0023 0.0166 0.0643
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0166 0.0166
Onchocerca volvulus 0.003 0.0253 0.0893
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0363 0.0947
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.003 0.0249 0.2908
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0112 0.0156
Entamoeba histolytica hypothetical protein 0.0037 0.0341 0.6796
Onchocerca volvulus 0.0014 0.0052 0.0183
Trypanosoma cruzi extracellular receptor, putative 0.0014 0.0045 0.0527
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.028 0.3272
Schistosoma mansoni hypothetical protein 0.0138 0.1592 0.3197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0321 0.0838
Treponema pallidum sodium- and chloride- dependent transporter 0.0015 0.0063 0.0094
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.01 0.1128 0.2264
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0102 0.0395
Echinococcus multilocularis nmda type glutamate receptor 0.0191 0.2261 0.2261
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0542 0.6652 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0363 1
Echinococcus multilocularis allatostatin A receptor 0.0023 0.0166 0.0166
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.0011 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0317 0.3835 1
Brugia malayi hypothetical protein 0.0023 0.0166 0.0643
Treponema pallidum hypothetical protein 0.0011 0.0009 0.0013
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0096 0.1071 0.1071
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0135
Schistosoma mansoni hypothetical protein 0.0023 0.0166 0.0334
Loa Loa (eye worm) hypothetical protein 0.0025 0.0187 0.0487
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0166 0.0334
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0112 0.0395
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0052 0.0135
Onchocerca volvulus 0.0014 0.0052 0.0183
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0166 0.0334
Brugia malayi ORL1-like opioid receptor 0.0023 0.0166 0.0643
Loa Loa (eye worm) solute carrier family 6 member 4 0.0015 0.0063 0.0164
Onchocerca volvulus 0.0012 0.0027 0.0095
Brugia malayi Cation transporter family protein 0.0018 0.0102 0.0395
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0014 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.001 0.0002 0.0005
Echinococcus granulosus g protein coupled receptor 0.0023 0.0166 0.0231
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0321 0.0321
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0084 0.0084
Brugia malayi hypothetical protein 0.0015 0.0063 0.0243
Echinococcus granulosus G protein coupled receptor 139 0.0023 0.0166 0.0231
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0102 0.0142
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Entamoeba histolytica hypothetical protein 0.0037 0.0341 0.6796
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0112 0.0156
Toxoplasma gondii hypothetical protein 0.0015 0.0063 0.0288
Echinococcus granulosus expressed protein 0.0373 0.4534 0.6304
Echinococcus granulosus collagen alpha 1VII chain 0.0011 0.0009 0.0012
Brugia malayi flavodoxin family protein 0.003 0.0249 0.0962
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Schistosoma mansoni rab6-interacting 0.002 0.0119 0.0239
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0164
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0052 0.0135
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0112 0.0225
Schistosoma mansoni glutamate receptor AMPA 0.0027 0.0209 0.042
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0041 0.0381 0.053
Loa Loa (eye worm) hypothetical protein 0.0118 0.1347 0.3512
Onchocerca volvulus 0.0018 0.0102 0.036
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0166 0.0166
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0125 0.0252
Giardia lamblia Hypothetical protein 0.007 0.0744 1
Schistosoma mansoni opsin-like receptor 0.0023 0.0166 0.0334
Echinococcus granulosus expressed protein 0.0033 0.029 0.0403
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0112 0.0112
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0014 0.0045 0.0118
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Schistosoma mansoni amine GPCR 0.0023 0.0166 0.0334
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0015 0.0063 0.0087
Echinococcus granulosus cyclin dependent kinase 5 0.005 0.0501 0.0697
Schistosoma mansoni rab6-interacting 0.002 0.0119 0.0239
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.01 0.1128 0.1568
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0102 0.0395
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0012 0.0027 0.0095
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0125 0.0327
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0112 0.0395
Echinococcus granulosus sex peptide receptor 0.0023 0.0166 0.0231
Echinococcus granulosus serotonin receptor 0.0023 0.0166 0.0231
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0166 0.0231
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0125 0.0485
Onchocerca volvulus 0.0018 0.0102 0.036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0036 0.0321 0.0838
Onchocerca volvulus 0.0011 0.0009 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0321 0.0838
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0166 0.0166
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0166 0.0166
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.005 0.0501 0.2296
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0166 0.0231
Echinococcus granulosus neuropeptide receptor 0.0023 0.0166 0.0231
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0321 0.0645
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0052 0.0237
Brugia malayi Pre-SET motif family protein 0.0209 0.248 0.9585
Brugia malayi PXA domain containing protein 0.0019 0.0112 0.0434
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0112 0.0225
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0027 0.0209 0.0291
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.011 0.022
Schistosoma mansoni ets 0.001 0.0002 0.0005
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0119 0.1302
Brugia malayi Dopamine receptor protein 1 0.0023 0.0166 0.0643
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0135
Onchocerca volvulus 0.0014 0.0052 0.0183
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0166 0.0334
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0253 0.0509
Schistosoma mansoni hypothetical protein 0.0037 0.0341 0.0684
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0023 0.0166 0.0166
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0102 0.0395
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0112 0.0112
Brugia malayi von Willebrand factor type A domain containing protein 0.0011 0.0009 0.0034
Schistosoma mansoni myosin xvIII 0.0023 0.0166 0.0334
Loa Loa (eye worm) aminopeptidase N 0.0012 0.0027 0.0071
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0363 0.4182
Loa Loa (eye worm) glutamate receptor 1 0.0027 0.0209 0.0545
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0501 0.1007
Onchocerca volvulus 0.0011 0.0009 0.0031
Onchocerca volvulus 0.0012 0.0027 0.0095
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0063 0.0126
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0027 0.0027
Echinococcus multilocularis lamin 0.0054 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.0012 0.0027 0.0071
Onchocerca volvulus 0.0014 0.0052 0.0183
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0102 0.0142
Brugia malayi hypothetical protein 0.0037 0.0341 0.1317
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0164
Schistosoma mansoni hypothetical protein 0.0023 0.0166 0.0334
Plasmodium vivax amine transporter, putative 0.0015 0.0063 0.0638
Onchocerca volvulus 0.0023 0.0166 0.0586
Brugia malayi GnHR receptor homolog 0.0023 0.0166 0.0643
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0253 0.0509
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0112 0.0225
Brugia malayi larval opioid receptor 0.0023 0.0166 0.0643
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0166 0.0166
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0027 0.0209 0.0209
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0166 0.0231
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0232 0.0322
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0321 0.0321
Schistosoma mansoni protein kinase 0.0014 0.0045 0.0091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0166 0.0334
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0069 0.0735 0.3363
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.005 0.0501 0.1308
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0232 0.2777 0.7241
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0052 0.0237
Brugia malayi nuclear receptor NHR-67 0.0017 0.0084 0.0326
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0166 0.0166
Echinococcus granulosus glutamate receptor 2 0.0014 0.0045 0.0063
Schistosoma mansoni rotamase 0.0033 0.029 0.0582
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus multilocularis aminopeptidase N 0.0012 0.0027 0.0027
Brugia malayi Zona pellucida-like domain containing protein 0.0011 0.0009 0.0034
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0112 0.0156
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0027 0.0209 0.0291
Brugia malayi putative neuropeptide receptor NPR1 0.0023 0.0166 0.0643
Schistosoma mansoni neuropeptide receptor 0.0023 0.0166 0.0334
Echinococcus granulosus orexin receptor type 2 0.0023 0.0166 0.0231
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0012 0.0027 0.0316
Echinococcus granulosus dnaJ subfamily B 0.0409 0.4981 0.6925
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0321 0.0645
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Loa Loa (eye worm) hypothetical protein 0.002 0.012 0.0314
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0102 0.0102
Trypanosoma brucei aminopeptidase, putative 0.0012 0.0027 0.0316
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0112 0.0434
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.012 0.1317
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0112 0.0112
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0102 0.0142
Echinococcus granulosus allatostatin A receptor 0.0023 0.0166 0.0231
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0512 0.5938
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0166 0.0231
Schistosoma mansoni growth hormone secretagogue receptor 0.0023 0.0166 0.0334
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0023 0.0166 0.0434
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0014 0.0045 0.0175
Brugia malayi PAN domain containing protein 0.0014 0.0052 0.0201
Brugia malayi PAN domain containing protein 0.0014 0.0052 0.0201
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0166 0.0231
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0063 0.0288
Brugia malayi Protein kinase domain containing protein 0.005 0.0501 0.1938
Echinococcus granulosus neuropeptide receptor 0.0023 0.0166 0.0231
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0166 0.0231
Giardia lamblia Kinase, CMGC CDK 0.005 0.0501 0.6738
Schistosoma mansoni ATP-binding cassette transporter 0.0027 0.0209 0.042
Leishmania major hypothetical protein, conserved 0.0022 0.015 0.0685
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0253 0.0253
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0112 0.0156
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0079 0.0856 1
Entamoeba histolytica type A flavoprotein, putative 0.003 0.0249 0.4964
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0321 0.0447
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0102 0.0395
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0232 0.2777 0.5575
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0079 0.0856 1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0041 0.0381 0.0381
Schistosoma mansoni glutamate receptor AMPA 0.0027 0.0209 0.042
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0027 0.0038
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0027 0.0038
Echinococcus granulosus metabotropic glutamate receptor 5 0.0014 0.0045 0.0063
Onchocerca volvulus 0.002 0.0119 0.0419
Schistosoma mansoni hypothetical protein 0.0022 0.015 0.0301
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Brugia malayi G protein-coupled receptor 0.0023 0.0166 0.0643
Brugia malayi ecdysone receptor 0.0017 0.0084 0.0326
Schistosoma mansoni intermediate filament proteins 0.0054 0.0549 0.1102
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0321 0.0645
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.028 0.1282
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0119 0.0119
Loa Loa (eye worm) FAD binding domain-containing protein 0.0049 0.048 0.1252
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0063 0.0087
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0015 0.0063 0.0063
Brugia malayi ecdysteroid receptor 0.0036 0.0321 0.1242
Onchocerca volvulus 0.0011 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0164
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0063 0.0087
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.012 0.0465
Echinococcus multilocularis lamin dm0 0.0054 0.0549 0.0549
Toxoplasma gondii hypothetical protein 0.0015 0.0063 0.0288
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0023 0.0166 0.0166
Trichomonas vaginalis rotamase, putative 0.0033 0.029 0.1021
Echinococcus granulosus neuropeptide receptor A26 0.0023 0.0166 0.0231
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0069 0.0735 0.3363
Schistosoma mansoni coup transcription factor 0.0036 0.0321 0.0645
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0166 0.0166
Brugia malayi Receptor family ligand binding region containing protein 0.0014 0.0045 0.0175
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0501 0.1766
Trypanosoma cruzi p450 reductase, putative 0.0079 0.0856 1
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.012 0.0424
Toxoplasma gondii PAN/Apple domain-containing protein 0.0014 0.0052 0.0237
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.005 0.0501 0.0697
Schistosoma mansoni biogenic amine receptor 0.0023 0.0166 0.0334
Echinococcus granulosus somatostatin receptor 0.0023 0.0166 0.0231
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Schistosoma mansoni ets-related 0.001 0.0002 0.0005
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0012 0.0027 0.0316
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0027 0.0038
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0286
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.029 0.1121
Trypanosoma cruzi cdc2-related kinase 1 0.005 0.0501 0.5858
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0063 0.0638
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.012 0.1405
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0023 0.0166 0.0334
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0045 0.0118
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0079 0.0856 0.0856
Toxoplasma gondii PAN domain-containing protein 0.0014 0.0052 0.0237
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0118
Echinococcus granulosus tumor protein p63 0.0352 0.4269 0.5934
Echinococcus granulosus nAChR subunit 0.0018 0.0102 0.0142
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0079 0.0856 0.119
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus granulosus lamin 0.0054 0.0549 0.0763
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0119 0.1302
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0321 0.1242
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0036 0.0321 0.0838
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0112 0.0395
Echinococcus granulosus tyrosine kinase 0.0014 0.0045 0.0063
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0069 0.0735 0.1104
Schistosoma mansoni aldehyde dehydrogenase 0.0185 0.2185 0.4386
Treponema pallidum 76K protein 0.0011 0.0009 0.0013
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0199 0.0277
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0063 0.0126
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0079 0.0856 0.3919
Echinococcus granulosus protein C ets 2 0.001 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0049 0.0488 0.1273
Echinococcus multilocularis geminin 0.0169 0.1989 0.1989
Onchocerca volvulus 0.0018 0.0102 0.036
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0102 0.0142
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0002 0.0006
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0321 0.0838
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0112 0.0293
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0012 0.0027 0.0054
Plasmodium falciparum transporter, putative 0.0015 0.0063 0.0638
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0102 0.0266
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0321 0.1242
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.001 0 0.5
Echinococcus granulosus leukotriene A 4 hydrolase 0.0232 0.2777 0.386
Echinococcus multilocularis glutamate receptor 2 0.0027 0.0209 0.0209
Echinococcus granulosus serotonin transporter 0.0015 0.0063 0.0087
Onchocerca volvulus 0.0051 0.0516 0.1818
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0027 0.0209 0.0209
Echinococcus multilocularis bloom syndrome protein 0.002 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0112 0.0293
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0102 0.0395
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0102 0.0266
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0363 0.724
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0002 0.0006
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.001 0 0.5
Brugia malayi PAN domain containing protein 0.0014 0.0052 0.0201
Loa Loa (eye worm) doublecortin family protein 0.002 0.0119 0.031
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0084 0.0117
Schistosoma mansoni nuclear receptor 0.0017 0.0084 0.0169
Echinococcus multilocularis expressed protein 0.0373 0.4534 0.4534
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0164
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0286
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0363 0.1279
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0119 0.0165
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0023 0.0166 0.0166
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.029 0.0756
Onchocerca volvulus 0.0023 0.0166 0.0586
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Loa Loa (eye worm) melatonin receptor type 1A 0.0023 0.0166 0.0434
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0166 0.0231
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0363 0.0363
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0102 0.0395
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0363 0.4241
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0166 0.0434
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0052 0.0135
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0102 0.0395
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0102 0.0102
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0027 0.0209 0.0209
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0321 0.0838
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.012 0.0167
Brugia malayi hypothetical protein 0.0012 0.0027 0.0105
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0235 0.0908
Entamoeba histolytica type A flavoprotein, putative 0.003 0.0249 0.4964
Brugia malayi PAN domain containing protein 0.0014 0.0052 0.0201
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0549 0.1431
Entamoeba histolytica hypothetical protein 0.0019 0.0112 0.2237
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0647 0.1299
Echinococcus granulosus nmda type glutamate receptor 0.0191 0.2261 0.3143
Plasmodium vivax SET domain protein, putative 0.003 0.0253 0.2888
Schistosoma mansoni hypothetical protein 0.0169 0.1989 0.3993
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0363 0.4878
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0023 0.0166 0.0334
Schistosoma mansoni adenoreceptor 0.0023 0.0166 0.0334
Brugia malayi hypothetical protein 0.002 0.0119 0.046
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0009 0.0034
Echinococcus granulosus glutamate receptor subunit protein glur 0.0027 0.0209 0.0291
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0025 0.0187 0.0487
Loa Loa (eye worm) hypothetical protein 0.0019 0.0112 0.0293
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Brugia malayi nuclear receptor NHR-88 0.0017 0.0084 0.0326
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0166 0.0231
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0321 0.0838
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Loa Loa (eye worm) CUTiclin-Like family member 0.0011 0.0009 0.0023
Schistosoma mansoni glutamate receptor kainate 0.0027 0.0209 0.042
Schistosoma mansoni glutamate receptor NMDA 0.0136 0.1572 0.3155
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0079 0.0856 1
Brugia malayi sulfakinin receptor protein 0.0023 0.0166 0.0643
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0023 0.0166 0.0586
Onchocerca volvulus 0.0023 0.0166 0.0586
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0102 0.0395
Brugia malayi CXXC zinc finger family protein 0.0029 0.0231 0.0895
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0363 0.1662
Echinococcus multilocularis cyclin dependent kinase 1 0.005 0.0501 0.0501
Brugia malayi follicle stimulating hormone receptor 0.0023 0.0166 0.0643
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0321 0.0321
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0022 0.015 0.1664
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0321 0.0447
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0012 0.0027 0.0316
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0069 0.0735 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0257 0.3083 0.4286
Echinococcus granulosus geminin 0.0169 0.1989 0.2765
Echinococcus granulosus voltage dependent calcium channel subunit 0.0266 0.3202 0.4452
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.012 0.1616
Echinococcus multilocularis receptor type guanylyl cyclase 0.0014 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Giardia lamblia Nitric oxide synthase, inducible 0.007 0.0744 1
Entamoeba histolytica type A flavoprotein, putative 0.003 0.0249 0.4964
Schistosoma mansoni hypothetical protein 0.0027 0.0209 0.042
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0014 0.0052 0.0135
Echinococcus multilocularis sex peptide receptor 0.0023 0.0166 0.0166
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0079 0.0856 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0102 0.0142
Brugia malayi PAN domain containing protein 0.0014 0.0052 0.0201
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0321 0.0447
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0084 0.0084
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0112 0.0434
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0102 0.0142
Loa Loa (eye worm) serotonin transporter b 0.0015 0.0063 0.0164
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0027 0.0124
Schistosoma mansoni hypothetical protein 0.0169 0.1989 0.3993
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0023 0.0166 0.0334
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.005 0.0501 0.2296
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0084 0.022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0102 0.0266
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0363 0.0546
Onchocerca volvulus 0.0023 0.0166 0.0586
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0321 0.0447
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0084 0.022
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0321 0.0645
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0012 0.0027 0.0316
Schistosoma mansoni lipoxygenase 0.002 0.0119 0.0239
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0112 0.0112
Brugia malayi G-protein coupled receptor 0.0023 0.0166 0.0643
Brugia malayi hypothetical protein 0.0023 0.0166 0.0643
Leishmania major extracellular receptor, putative 0.0014 0.0045 0.0207
Echinococcus granulosus RUN 0.002 0.0119 0.0165
Treponema pallidum flavodoxin 0.003 0.0249 0.0374
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0512 0.5938
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0112 0.0395
Toxoplasma gondii microneme protein MIC17A 0.0014 0.0052 0.0237
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0321 0.1132
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.012 0.0551
Brugia malayi Tachykinin-like peptides receptor 99D 0.0023 0.0166 0.0643
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0166 0.0231
Onchocerca volvulus 0.0012 0.0027 0.0095
Brugia malayi von Willebrand factor type A domain containing protein 0.0011 0.0009 0.0034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Schistosoma mansoni neuropeptide receptor 0.0023 0.0166 0.0334
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0011 0.0009 0.004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0321 0.0838
Loa Loa (eye worm) hypothetical protein 0.0019 0.0112 0.0293
Brugia malayi hypothetical protein 0.0017 0.0084 0.0326
Schistosoma mansoni hypothetical protein 0.0011 0.0009 0.0018
Loa Loa (eye worm) RecQ helicase 0.002 0.012 0.0314
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0102 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0321 0.1242
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0012 0.0027 0.0216
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0012 0.0027 0.0316
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0063 0.0063
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0257 0.3083 0.3083
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0166 0.0434
Plasmodium falciparum amino acid transporter, putative 0.0015 0.0063 0.0638
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0102 0.0142
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Chlamydia trachomatis glutamine binding protein 0.0069 0.0735 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0023 0.0166 0.0166
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0363 0.1403
Toxoplasma gondii flavodoxin domain-containing protein 0.0039 0.0361 0.1651
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0002 0.0006
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0012 0.0027 0.0095
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0166 0.0166
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0102 0.0205
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0321 0.0645
Trichomonas vaginalis NADPH cytochrome P450, putative 0.003 0.0249 0.0877
Schistosoma mansoni metabotropic glutamate receptor 0.0014 0.0045 0.0091
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.028 0.5585
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0286
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0185 0.2185 0.3037
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0286
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0164
Echinococcus multilocularis serotonin receptor 0.0023 0.0166 0.0166
Schistosoma mansoni polycystin 1-related 0.002 0.0119 0.0239
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.028 0.1282
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Onchocerca volvulus Putative nachr subunit 0.0018 0.0102 0.036
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.248 0.6467
Echinococcus multilocularis protein C ets 2 0.001 0.0002 0.0002
Schistosoma mansoni biogenic amine receptor 0.0023 0.0166 0.0334
Echinococcus granulosus cyclin dependent kinase 0.005 0.0501 0.0697
Entamoeba histolytica recQ family helicase, putative 0.002 0.012 0.2399
Echinococcus granulosus cyclin dependent kinase 1 0.005 0.0501 0.0697
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.011 0.0424
Echinococcus multilocularis glutamate receptor 2 0.0041 0.0381 0.0381
Toxoplasma gondii hypothetical protein 0.0014 0.0052 0.0237
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0012 0.0027 0.0095
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus granulosus cpg binding protein 0.003 0.0252 0.035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0549 0.2121
Brugia malayi hypothetical protein 0.0023 0.0166 0.0643
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0084 0.0117
Toxoplasma gondii flavodoxin domain-containing protein 0.0039 0.0361 0.1651
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0084 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0321 0.1242
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0084 0.0117
Loa Loa (eye worm) RGC/RGC protein kinase 0.0014 0.0045 0.0118
Schistosoma mansoni cell polarity protein 0.0024 0.0175 0.0352
Echinococcus multilocularis serotonin receptor 0.0023 0.0166 0.0166
Schistosoma mansoni slit 0.0024 0.0175 0.0352
Brugia malayi EGF-like domain containing protein 0.0024 0.0175 0.0677
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0027 0.0027
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0235 0.0612
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0119 0.0165
Echinococcus multilocularis nAChR subunit 0.0018 0.0102 0.0102
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0014 0.0045 0.0118
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0767 0.0767
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0102 0.0102
Echinococcus granulosus receptor type guanylyl cyclase 0.0014 0.0045 0.0063
Schistosoma mansoni nAChR subunit 0.0018 0.0102 0.0205
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0549 0.1431
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.012 0.012
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0253 0.0352
Echinococcus multilocularis dro:myosuppressin receptor 0.0023 0.0166 0.0166
Brugia malayi Serotonin receptor 0.0023 0.0166 0.0643
Trypanosoma cruzi cdc2-related kinase 3 0.005 0.0501 0.5858
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0012 0.0027 0.0027
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.011 0.0286
Brugia malayi tailless protein 0.0017 0.0084 0.0326
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.012 0.0465
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0027 0.0124
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.015 0.1749
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.012 0.0551
Echinococcus multilocularis orexin receptor type 2 0.0023 0.0166 0.0166
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0321 0.0838
Brugia malayi Cache domain containing protein 0.0118 0.1347 0.5205
Loa Loa (eye worm) hypothetical protein 0.0024 0.0175 0.0457
Loa Loa (eye worm) hypothetical protein 0.0054 0.0549 0.1431
Schistosoma mansoni aldehyde dehydrogenase 0.0185 0.2185 0.4386
Schistosoma mansoni hypothetical protein 0.002 0.0119 0.0239
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0118
Echinococcus multilocularis slit 2 protein 0.0024 0.0175 0.0175
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.028 0.3272
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0166 0.0334
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0102 0.0395
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0321 0.1242
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0321 0.0321
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0102 0.0266
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Toxoplasma gondii microneme protein, putative 0.0014 0.0052 0.0237
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0002 0.001
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0014 0.0045 0.0118
Mycobacterium ulcerans aminopeptidase N PepN 0.0012 0.0027 0.0124
Brugia malayi hypothetical protein 0.0122 0.1393 0.5384
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0166 0.0231
Brugia malayi PXA domain containing protein 0.0019 0.0112 0.0434
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0157 0.041
Echinococcus granulosus atrial natriuretic peptide receptor 0.0014 0.0045 0.0063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0118
Onchocerca volvulus 0.0036 0.0321 0.1132
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Brugia malayi hypothetical protein 0.0023 0.0166 0.0643
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0501 0.1007
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0041 0.0381 0.053
Brugia malayi hypothetical protein 0.0017 0.0084 0.0326
Schistosoma mansoni alpha-1 adrenergic receptor 0.0023 0.0166 0.0334
Trichomonas vaginalis NADPH cytochrome P450, putative 0.003 0.0249 0.0877
Schistosoma mansoni amine GPCR 0.0023 0.0166 0.0334
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0321 0.1242
Loa Loa (eye worm) abnormal epIthelia family member 0.0024 0.0175 0.0457
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0023 0.0166 0.0434
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0112 0.0112
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0084 0.0169
Toxoplasma gondii microneme protein MIC4 0.0014 0.0052 0.0237
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.031
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0112 0.0225
Brugia malayi G-protein coupled receptor 0.0023 0.0166 0.0643
Toxoplasma gondii microneme protein MIC17B 0.0014 0.0052 0.0237
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0166 0.0334
Schistosoma mansoni amine GPCR 0.0023 0.0166 0.0334
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0102 0.0266
Onchocerca volvulus 0.0018 0.0102 0.036
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0014 0.0045 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0321 0.1242
Plasmodium falciparum cysteine repeat modular protein 1 0.0022 0.015 0.1664
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0166 0.0166
Echinococcus multilocularis glutamate receptor 2 0.0014 0.0045 0.0045
Trichomonas vaginalis set domain proteins, putative 0.0237 0.2839 1
Echinococcus granulosus glutamate receptor 2 0.0041 0.0381 0.053
Brugia malayi Melatonin receptor type 1A 0.0023 0.0166 0.0643
Toxoplasma gondii microneme protein MIC17C 0.0014 0.0052 0.0237
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.011 0.0153
Onchocerca volvulus 0.0023 0.0166 0.0586
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0024 0.0175 0.0677
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.012 0.1405
Onchocerca volvulus 0.0023 0.0166 0.0586
Echinococcus granulosus metabotropic glutamate receptor 2 0.0014 0.0045 0.0063
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0049 0.048 0.0964
Echinococcus multilocularis methionine synthase reductase 0.0049 0.048 0.048
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.001 0 0.5
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0015 0.0063 0.0243
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0102 0.0142
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0256 0.3066 0.6156
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0027 0.0209 0.0291
Brugia malayi hypothetical protein 0.0023 0.0166 0.0643
Onchocerca volvulus 0.0014 0.0052 0.0183
Brugia malayi conserved hypotetical protein 0.0017 0.0084 0.0326
Onchocerca volvulus 0.0011 0.0009 0.0031
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0084 0.0169
Echinococcus granulosus pikachurin 0.0024 0.0175 0.0244
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0041 0.0381 0.053
Onchocerca volvulus 0.0054 0.0549 0.1933
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0166 0.0231
Echinococcus multilocularis G protein coupled receptor 139 0.0023 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0363 0.0505
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0023 0.0166 0.0434
Brugia malayi PAN domain containing protein 0.0014 0.0052 0.0201
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.007 0.0744 0.2622
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0023 0.0166 0.0231
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0125 0.0174
Onchocerca volvulus 0.0023 0.0166 0.0586
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0166 0.0434
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0363 0.1662
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0012 0.0027 0.0054
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0166 0.0166
Echinococcus granulosus tachykinin peptides receptor 99D 0.0023 0.0166 0.0231
Brugia malayi PAN domain containing protein 0.0014 0.0052 0.0201
Loa Loa (eye worm) flavodoxin family protein 0.003 0.0249 0.0649
Loa Loa (eye worm) peptidase family M1 containing protein 0.0012 0.0027 0.0071
Echinococcus multilocularis g-protein coupled receptor 0.0023 0.0166 0.0166
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0041 0.0381 0.0381
Schistosoma mansoni metabotropic glutamate receptor 0.0014 0.0045 0.0091
Schistosoma mansoni nAChR subunit 0.0018 0.0102 0.0205
Loa Loa (eye worm) hypothetical protein 0.0019 0.0112 0.0293
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Loa Loa (eye worm) hypothetical protein 0.0036 0.0321 0.0838
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0102 0.0395
Onchocerca volvulus 0.0023 0.0166 0.0586
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0166 0.0231
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0321 0.0447
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0321 0.1132
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0118
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Onchocerca volvulus 0.0015 0.0063 0.0221
Echinococcus granulosus 7TM GPCR rhodopsin 0.0023 0.0166 0.0231
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0166 0.0334
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0434
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0015 0.0066 0.0132
Brugia malayi Ets-domain containing protein 0.0072 0.0767 0.2964
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Loa Loa (eye worm) hypothetical protein 0.0079 0.0856 0.2232
Onchocerca volvulus 0.0011 0.0009 0.0031
Loa Loa (eye worm) PAN domain-containing protein 0.0014 0.0052 0.0135
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0321 0.0447
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.022
Toxoplasma gondii aldehyde dehydrogenase 0.0185 0.2185 1
Brugia malayi hypothetical protein 0.0019 0.011 0.0424
Loa Loa (eye worm) hypothetical protein 0.0036 0.0321 0.0838
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0023 0.0166 0.0166
Echinococcus granulosus g protein coupled receptor 0.0023 0.0166 0.0231
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0014 0.0045 0.09
Brugia malayi nuclear receptor RXR 0.0019 0.011 0.0424
Schistosoma mansoni hypothetical protein 0.0023 0.0166 0.0334
Trypanosoma brucei cdc2-related kinase 1 0.005 0.0501 0.5858
Loa Loa (eye worm) hypothetical protein 0.0019 0.0112 0.0293
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0253 0.0509
Schistosoma mansoni aminopeptidase A (M01 family) 0.0012 0.0027 0.0054
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0012 0.0027 0.0216
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0363 0.4241
Schistosoma mansoni gabp alpha 0.0072 0.0767 0.154
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.012 0.0551
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0266
Entamoeba histolytica hypothetical protein 0.0011 0.0009 0.0174
Schistosoma mansoni cpg binding protein 0.003 0.0252 0.0506
Schistosoma mansoni hypothetical protein 0.0023 0.0166 0.0334
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0002 0.0003
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0027 0.0038
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0094 0.1042 0.1042
Brugia malayi Metabotropic glutamate receptor precursor. 0.0014 0.0045 0.0175
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0166 0.0166
Entamoeba histolytica hypothetical protein, conserved 0.0011 0.0009 0.0174
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0102 0.0266
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.012 0.1317
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0063 0.0063
Echinococcus granulosus tissue type plasminogen activator 0.0022 0.015 0.0208
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0363 0.4241
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0023
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0041 0.0381 0.053
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0079 0.0856 0.0856
Brugia malayi hypothetical protein 0.0023 0.0166 0.0643
Brugia malayi Kringle domain containing protein 0.0022 0.015 0.0579
Loa Loa (eye worm) hypothetical protein 0.003 0.0253 0.0661
Onchocerca volvulus 0.0017 0.0084 0.0297
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0501 0.1766
Loa Loa (eye worm) hypothetical protein 0.0036 0.0321 0.0838
Echinococcus multilocularis somatostatin receptor 0.0023 0.0166 0.0166
Echinococcus granulosus hypothetical protein 0.0023 0.0166 0.0231
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0118
Onchocerca volvulus 0.0022 0.015 0.0527
Brugia malayi hypothetical protein 0.0107 0.1208 0.4668
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0562 0.0782
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0006
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0015 0.0063 0.0063
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.012 0.0167
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0102 0.0266
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0011 0.0009 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0166 0.0166
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0512 0.598
Brugia malayi Dopamine receptor 0.0023 0.0166 0.0643
Brugia malayi Ets-domain containing protein 0.001 0.0002 0.001
Echinococcus granulosus neuropeptide FF receptor 2 0.0023 0.0166 0.0231
Loa Loa (eye worm) hypothetical protein 0.0053 0.0536 0.1399
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0063 0.0126
Brugia malayi Bloom's syndrome protein homolog 0.002 0.012 0.0465
Echinococcus multilocularis tissue type plasminogen activator 0.0022 0.015 0.015
Loa Loa (eye worm) TK/ROR protein kinase 0.0022 0.015 0.039

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Antagonist activity at glycine site of NMDA receptor in rat brain cortex membrane assessed as inhibition of [3H]Mk-801 binding by liquid scintillation counting in presence of maximally active glycine and antagonist 5,7-dichlorokynurenic acid ChEMBL. 19642674
EC50 (functional) = 16000 nM Inhibition of NMDA-induced depolarizations in rat cortical wedges. ChEMBL. 11384240
EC50 (binding) = 9.5 uM In vitro concentration of the compound eliciting half-maximal effect on [3H]-MK 801 radioligand binding to NMDA receptor ChEMBL. 10360746
EC50 (binding) = 9.5 uM In vitro concentration of the compound eliciting half-maximal effect on [3H]-MK 801 radioligand binding to NMDA receptor ChEMBL. 10360746
ED50 (functional) = 5.1 mg kg-1 In vivo antagonist activity against seizures elicited by audiogenic administered intra peritoneally in mice ChEMBL. 7990104
ED50 (functional) = 5.1 mg kg-1 In vivo antagonist activity against seizures elicited by audiogenic administered intra peritoneally in mice ChEMBL. 7990104
ED50 (functional) = 13 mg kg-1 Antagonist activity in PTZ seizure model in vivo through intravenous route ChEMBL. 7990104
ED50 (functional) = 13 mg kg-1 Antagonist activity in PTZ seizure model in vivo through intravenous route ChEMBL. 7990104
ED50 (functional) = 13.5 mg kg-1 Antagonist activity for neuroprotection, in rat MCAO in vivo through intravenous bolus+infusion route ChEMBL. 7990104
ED50 (functional) = 13.5 mg kg-1 Antagonist activity for neuroprotection, in rat MCAO in vivo through intravenous bolus+infusion route ChEMBL. 7990104
ED50 (functional) = 20 mg kg-1 In vivo antagonist activity against seizures elicited by NMDLA in mice administered intravenously ChEMBL. 7990104
ED50 (functional) = 20 mg kg-1 In vivo antagonist activity against seizures elicited by NMDLA in mice administered intravenously ChEMBL. 7990104
ED50 (functional) = 26 mg kg-1 Antagonist activity in electroshock model in vivo through intravenous route ChEMBL. 7990104
ED50 (functional) = 26 mg kg-1 Antagonist activity in electroshock model in vivo through intravenous route ChEMBL. 7990104
ED50 (functional) = 44 mg kg-1 In vivo antagonist activity against seizures elicited by NMDA in mice administered perorally ChEMBL. 7990104
ED50 (functional) = 44 mg kg-1 In vivo antagonist activity against seizures elicited by NMDA in mice administered perorally ChEMBL. 7990104
IC50 (binding) = 1200 nM Binding affinity at glycine binding site of NMDA receptor in rat cortical membranes by [3H]-L-689,560 displacement. ChEMBL. 11384240
IC50 (binding) = 1200 nM Binding affinity at glycine binding site of NMDA receptor in rat cortical membranes by [3H]-L-689,560 displacement. ChEMBL. 11384240
IC50 (binding) = 1.4 uM Inhibition of [3H]-glycine binding to rat cortical membranes ChEMBL. No reference
IC50 (binding) = 1.4 uM In vitro inhibition of [3H]-Glycine at NMDA receptor ChEMBL. 7990104
IC50 (binding) = 1.4 uM Inhibition of [3H]-glycine binding to rat cortical membranes ChEMBL. No reference
IC50 (binding) = 1.4 uM In vitro inhibition of [3H]-Glycine at NMDA receptor ChEMBL. 7990104
IC50 (binding) = 1.87 uM In vitro inhibitory activity of the compound to inhibit [3H]-glycine binding to NMDA receptor ChEMBL. 10360746
IC50 (binding) = 1.87 uM In vitro inhibitory activity of the compound to inhibit [3H]-glycine binding to NMDA receptor ChEMBL. 10360746
IC50 (binding) = 2.7 uM Displacement of [3H]L-689,560 from NMDA receptor glycine site of rat brain membranes ChEMBL. No reference
IC50 (binding) = 2.7 uM Displacement of [3H]L-689,560 from NMDA receptor glycine site of rat brain membranes ChEMBL. No reference
IC50 (binding) = 2.9 uM Inhibition of [3H]-glycine binding to rat cortical membranes ChEMBL. No reference
IC50 (binding) = 2.9 uM Inhibition of [3H]-glycine binding to rat cortical membranes ChEMBL. No reference
Kb (binding) = 15 uM In vitro inhibition of cortical slice at NMDA receptor ChEMBL. 7990104
Kb (functional) = 15 uM Tested for ability of the compound to inhibit NMDA-induced depolarizations in rat cortical slices ChEMBL. No reference
Kb (binding) = 15 uM In vitro inhibition of cortical slice at NMDA receptor ChEMBL. 7990104
Ki (functional) = 0.65 uM Tested in vitro for the inhibitory constant of glycine (0.3 microM) responses in isolated cultured cortical neurones ChEMBL. No reference
Ki (binding) = 0.65 uM Compound was evaluated for in vitro inhibition of cortical neuron at NMDA receptor ChEMBL. 7990104
Ki (binding) = 0.65 uM Compound was evaluated for in vitro inhibition of cortical neuron at NMDA receptor ChEMBL. 7990104
Ki (functional) = 1.3 uM Compound was evaluated in vitro for the inhibitory activity of glycine (0.3 microM) responses in isolated cultured cortical neurons ChEMBL. No reference
logD = 3.42 Compound was evaluated for the octanol-water partition coefficient following intravenous administration at pH 7.4 ChEMBL. No reference
ME (binding) = 18 % In vitro maximal effect of the compound on [3H]-MK 801 binding to NMDA receptor as compared to a basal value of 100% ChEMBL. 10360746
No. protected/ No.dosed (functional) = 5 Ability to prevent NMDA-induced hyperlocomotion in the mouse following iv administration of 10 mg/kg dose; 5/10 ChEMBL. 11384240
No. protected/ No.dosed (functional) = 10 Ability to prevent NMDA-induced hyperlocomotion in the mouse following iv administration of 30 mg/kg dose; 10/10 ChEMBL. 11384240
No. protected/ No.dosed (functional) = 5 Ability to prevent NMDA-induced hyperlocomotion in the mouse following iv administration of 10 mg/kg dose; 5/10 ChEMBL. 11384240
No. protected/ No.dosed (functional) = 10 Ability to prevent NMDA-induced hyperlocomotion in the mouse following iv administration of 30 mg/kg dose; 10/10 ChEMBL. 11384240
pKa = 8 Compound was evaluated for the pKa value ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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