Detailed information for compound 44173

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 265.113 | Formula: C10H12Cl2NO3-
  • H donors: 2 H acceptors: 2 LogP: 2.62 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1cc(Cl)c(c(c1)CN)O.[Cl-]
  • InChi: 1S/C10H12ClNO3.ClH/c1-2-15-10(14)6-3-7(5-12)9(13)8(11)4-6;/h3-4,13H,2,5,12H2,1H3;1H/p-1
  • InChiKey: ZUPGNYKKZVIHPP-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0021 0.0053 0.0063
Brugia malayi jmjC domain containing protein 0.0101 0.0506 0.0601
Plasmodium vivax SET domain protein, putative 0.0097 0.0482 0.9772
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0039 0.0153 0.0534
Plasmodium vivax acetyl-CoA synthetase, putative 0.0039 0.0153 0.3101
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0222 0.0527
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0341
Brugia malayi jmjC domain containing protein 0.0043 0.0176 0.0209
Plasmodium vivax importin-beta 2, putative 0.0063 0.0289 0.585
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0058 0.0064
Echinococcus multilocularis snurportin 1 0.0668 0.373 0.373
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0099 0.0493 0.1628
Loa Loa (eye worm) MH2 domain-containing protein 0.0273 0.1484 0.2198
Trichomonas vaginalis ap endonuclease, putative 0.0064 0.0299 0.0711
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0058 0.0058
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0668 0.373 0.5526
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0058 0.0086
Echinococcus multilocularis peregrin 0.0034 0.0129 0.0128
Echinococcus multilocularis synaptojanin 1 0.0016 0.0024 0.0023
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0024 0.0028
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0039 0.0153 0.0534
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0399 0.1547
Schistosoma mansoni ap endonuclease 0.0064 0.0299 0.0331
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0064 0.0299 0.0331
Trichomonas vaginalis set domain proteins, putative 0.0752 0.4206 1
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0033 0.0123 0.0343
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0024 0.0034
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0048 0.0207 0.0306
Echinococcus multilocularis thioredoxin glutathione reductase 0.0061 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0064 0.03 0.0443
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0016 0.0024 0.0026
Brugia malayi Calcitonin receptor-like protein seb-1 0.0202 0.1078 0.1283
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0153 0.1592
Schistosoma mansoni microtubule-associated protein tau 0.1602 0.9032 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0132 0.0683 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0024 0.0341
Loa Loa (eye worm) hypothetical protein 0.0031 0.0108 0.0159
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0058 0.0064
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0039 0.0153 0.1592
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0016 0.0024 0.0056
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0039 0.0153 0.1592
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0024 0.0472
Loa Loa (eye worm) acetyltransferase 0.0149 0.078 0.1155
Onchocerca volvulus 0.0039 0.0153 0.031
Schistosoma mansoni smad1 5 8 and 0.0019 0.0039 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0058 0.0137
Brugia malayi MH1 domain containing protein 0.0019 0.0039 0.0046
Echinococcus granulosus histone lysine methyltransferase setb 0.0097 0.0482 0.0533
Loa Loa (eye worm) hypothetical protein 0.0132 0.0683 0.1011
Brugia malayi AMP-binding enzyme family protein 0.0132 0.0683 0.0812
Loa Loa (eye worm) hypothetical protein 0.0099 0.0493 0.073
Loa Loa (eye worm) histone methyltransferase 0.0033 0.0123 0.0182
Loa Loa (eye worm) hypothetical protein 0.0376 0.2067 0.3062
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0021 0.0053 0.1068
Loa Loa (eye worm) transcription factor SMAD2 0.0273 0.1484 0.2198
Brugia malayi F/Y-rich N-terminus family protein 0.0043 0.0178 0.0211
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0058 0.0058
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0347 0.2106
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0016 0.0024 0.0341
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0058 0.0064
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.002 0.0048 0.0959
Loa Loa (eye worm) oxidoreductase 0.0039 0.0153 0.0227
Loa Loa (eye worm) hypothetical protein 0.0039 0.0153 0.0227
Trypanosoma brucei trypanothione reductase 0.0061 0.0279 0.1138
Echinococcus granulosus thioredoxin glutathione reductase 0.0061 0.0279 0.0309
Brugia malayi AMP-binding enzyme family protein 0.0039 0.0153 0.0182
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0016 0.0024 0.0141
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0039 0.0153 0.0182
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0153 0.1592
Echinococcus multilocularis traf and tnf receptor associated protein 0.0016 0.0024 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0058 0.0137
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0053 0.0121
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0021 0.0055 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0058 0.0137
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0053 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0058 0.0137
Trichomonas vaginalis mercuric reductase, putative 0.0021 0.0053 0.0126
Schistosoma mansoni hypothetical protein 0.0064 0.0296 0.0327
Entamoeba histolytica hypothetical protein 0.0051 0.0222 0.324
Echinococcus multilocularis Smad4 0.0019 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.0079 0.0383 0.0567
Schistosoma mansoni inositol 145-trisphosphate receptor 0.1342 0.7555 0.8365
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0064 0.0299 0.4377
Toxoplasma gondii HEAT repeat-containing protein 0.0063 0.0289 0.2843
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0053 0.0215
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0443 0.245 1
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0016 0.0024 0.0474
Echinococcus granulosus traf and tnf receptor associated protein 0.0016 0.0024 0.0026
Leishmania major GTP-binding protein, putative 0.0046 0.0195 0.1183
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0058 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0058 0.0069
Onchocerca volvulus 0.0097 0.0482 0.1096
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0034
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0347 0.466
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0053 0.0121
Leishmania major trypanothione reductase 0.0061 0.0279 0.1696
Schistosoma mansoni hypothetical protein 0.0064 0.0296 0.0327
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0058 0.0064
Mycobacterium tuberculosis Probable lipase LipD 0.0082 0.0399 0.1301
Onchocerca volvulus 0.0064 0.03 0.0659
Toxoplasma gondii thioredoxin reductase 0.0061 0.0279 0.2747
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0099 0.0493 0.6991
Echinococcus multilocularis mothers against decapentaplegic 5 0.0019 0.0039 0.0038
Echinococcus granulosus geminin 0.0545 0.3027 0.3351
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0058 0.0064
Loa Loa (eye worm) beta-lactamase 0.0082 0.0399 0.0591
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0039 0.0153 0.1592
Schistosoma mansoni ap endonuclease 0.0064 0.0299 0.0331
Leishmania major acetyl-CoA synthetase, putative 0.0039 0.0153 0.093
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0195 0.0706
Onchocerca volvulus 0.0039 0.0153 0.031
Echinococcus multilocularis microtubule associated protein 2 0.1602 0.9032 0.9032
Plasmodium falciparum glutathione reductase 0.0021 0.0053 0.1068
Mycobacterium ulcerans hypothetical protein 0.0132 0.0683 1
Onchocerca volvulus 0.0022 0.0058 0.0082
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0024 0.0034
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0035 0.0134 0.0148
Trypanosoma cruzi hypothetical protein, conserved 0.0082 0.0399 0.1547
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0039 0.0153 0.0227
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0209 0.1119 0.1238
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0053 0.0215
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0341
Loa Loa (eye worm) CXXC zinc finger family protein 0.0097 0.0483 0.0715
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0021 0.0053 0.0058
Leishmania major RNA-editing complex protein MP100, putative 0.0016 0.0024 0.0141
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0347 0.466
Loa Loa (eye worm) hypothetical protein 0.0325 0.178 0.2637
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0048 0.0207 0.0207
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0064 0.0299 1
Schistosoma mansoni coup transcription factor 0.0022 0.0058 0.0064
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.0222 0.0816
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0399 0.0949
Loa Loa (eye worm) hypothetical protein 0.0325 0.178 0.2637
Plasmodium vivax acyl-CoA synthetase, putative 0.0099 0.0493 1
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0039 0.0153 0.1592
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0463 0.1522
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0161 0.5
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0086
Leishmania major 4-coumarate:coa ligase-like protein 0.0132 0.0683 0.4153
Echinococcus granulosus neutral sphingomyelinase 0.0016 0.0024 0.0026
Loa Loa (eye worm) hypothetical protein 0.0132 0.0683 0.1011
Loa Loa (eye worm) hypothetical protein 0.12 0.6749 1
Echinococcus granulosus snurportin 1 0.0668 0.373 0.4129
Onchocerca volvulus 0.0132 0.0683 0.1576
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.002 0.0048 0.0056
Onchocerca volvulus 0.0082 0.0399 0.0897
Leishmania major hypothetical protein, conserved 0.0301 0.1644 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.0716 0.106
Trichomonas vaginalis penicillin-binding protein, putative 0.0082 0.0399 0.0949
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0046 0.0195 0.6216
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.078 0.0927
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0347 0.0383
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0229
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0296 0.0295
Plasmodium vivax hypothetical protein, conserved 0.0082 0.0399 0.8085
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0296 0.0437
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0039 0.0153 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0058 0.0069
Loa Loa (eye worm) hypothetical protein 0.0099 0.0493 0.073
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0058 0.0137
Mycobacterium ulcerans hypothetical protein 0.0082 0.0399 0.5492
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0024 0.0095
Loa Loa (eye worm) hypothetical protein 0.0099 0.0493 0.073
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0182 0.0201
Trichomonas vaginalis ran, putative 0.0046 0.0195 0.0463
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0024 0.0474
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0016 0.0024 0.0056
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0097 0.0482 0.0482
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0021 0.0053 0.0053
Plasmodium falciparum importin beta, putative 0.0063 0.0289 0.585
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0016 0.0024 0.0095
Echinococcus granulosus smad 0.0019 0.0039 0.0042
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0506 0.056
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0132 0.0683 0.2285
Mycobacterium tuberculosis Probable esterase LipL 0.0082 0.0399 0.1301
Mycobacterium tuberculosis Probable lipase LipE 0.0082 0.0399 0.1301
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0053 0.0121
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0082 0.0399 0.5492
Brugia malayi MIR domain containing protein 0.0082 0.0401 0.0476
Loa Loa (eye worm) Plcb4 protein 0.0047 0.02 0.0296
Brugia malayi exodeoxyribonuclease III family protein 0.0064 0.0299 0.0355
Schistosoma mansoni synaptojanin 0.0016 0.0024 0.0026
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0294 0.0435
Brugia malayi CXXC zinc finger family protein 0.0097 0.0483 0.0574
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0182 0.0433
Brugia malayi beta-lactamase family protein 0.0082 0.0399 0.0474
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0039 0.0153 0.0449
Echinococcus granulosus ryanodine receptor 44f 0.0292 0.1589 0.1759
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0132 0.0683 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0082 0.0399 0.1301
Mycobacterium ulcerans acyl-CoA synthetase 0.0132 0.0683 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0021 0.0025
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0028 0.0089 0.0089
Mycobacterium tuberculosis Conserved protein 0.0082 0.0399 0.1301
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0064 0.0299 0.1135
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0482 0.0533
Schistosoma mansoni ran 0.0046 0.0195 0.0215
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0039 0.0153 0.0449
Entamoeba histolytica acyl-CoA synthetase, putative 0.0132 0.0683 1
Loa Loa (eye worm) glutathione reductase 0.0061 0.0279 0.0413
Schistosoma mansoni inositol 145-trisphosphate receptor 0.1116 0.6271 0.6943
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0039 0.0153 0.093
Schistosoma mansoni hypothetical protein 0.0545 0.3027 0.3351
Mycobacterium ulcerans acyl-CoA synthetase 0.0132 0.0683 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0132 0.0683 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0046 0.0195 0.0794
Entamoeba histolytica Ran family GTPase 0.0046 0.0195 0.2849
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0058 0.0137
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0082 0.0399 0.0474
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0058 0.0137
Echinococcus granulosus beta LACTamase domain containing family member 0.0082 0.0399 0.0441
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0153 0.1592
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0058 0.0137
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0039 0.0153 0.0534
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0024 0.0028
Entamoeba histolytica hypothetical protein 0.0035 0.0132 0.1925
Trichomonas vaginalis esterase, putative 0.0082 0.0399 0.0949
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0053 0.032
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0058 0.0058
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0021 0.0055 0.008
Mycobacterium tuberculosis Probable hydrolase 0.0082 0.0399 0.1301
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.1038 0.1149
Brugia malayi RNA, U transporter 1 0.0178 0.0945 0.1123
Trypanosoma cruzi trypanothione reductase, putative 0.0021 0.0053 0.0121
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0229
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0058 0.0137
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0024 0.0026
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0088 0.0431 0.0477
Onchocerca volvulus 0.0752 0.4206 1
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0058 0.0064
Brugia malayi MH2 domain containing protein 0.0019 0.0039 0.0046
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0039 0.0153 0.1507
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0024 0.007 0.0102
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0296 0.0327
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0021 0.0025
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0039 0.0153 0.3101
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0058 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0058 0.0086
Leishmania major hypothetical protein, conserved 0.0016 0.0024 0.0141
Echinococcus multilocularis dnaJ subfamily B 0.1378 0.7761 0.7761
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0089 0.0089
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0132 0.0683 1
Echinococcus granulosus importin subunit beta 1 0.0063 0.0289 0.0319
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0016 0.0024 0.0341
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0039 0.0153 0.1592
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0153 0.0449
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0089 0.0099
Trichomonas vaginalis helicase, putative 0.0022 0.0058 0.0137
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0046 0.0195 0.3945
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.002 0.0048 0.0288
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0039 0.0153 0.1592
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0058 0.0064
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0039 0.0153 0.1592
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.1038 0.1149
Echinococcus multilocularis cpg binding protein 0.0102 0.0514 0.0514
Onchocerca volvulus 0.0048 0.0207 0.0439
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.0756 0.0837
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0058 0.0069
Schistosoma mansoni hypothetical protein 0.0545 0.3027 0.3351
Loa Loa (eye worm) hypothetical protein 0.0099 0.0493 0.073
Schistosoma mansoni cellular tumor antigen P53 0.0059 0.027 0.0298
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.007
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0024 0.0028
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0525 0.2917 0.3471
Mycobacterium ulcerans esterase/lipase LipP 0.0082 0.0399 0.5492
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0108 0.0119
Echinococcus multilocularis ryanodine receptor 44f 0.0376 0.2067 0.2067
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0034
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0058 0.0082
Echinococcus granulosus peregrin 0.0034 0.0129 0.0142
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0024 0.0028
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.1038 0.1038
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0039 0.0153 0.0624
Onchocerca volvulus 0.0097 0.0483 0.1098
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0176 0.026
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0108 0.106
Brugia malayi Smad1 0.0019 0.0039 0.0046
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0341
Trichomonas vaginalis hypothetical protein 0.0012 0 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0482 0.0533
Mycobacterium tuberculosis Probable oxidoreductase 0.0021 0.0053 0.0102
Schistosoma mansoni hypothetical protein 0.1378 0.7761 0.8593
Brugia malayi ecdysteroid receptor 0.0022 0.0058 0.0069
Brugia malayi cation channel family protein 0.1491 0.8405 1
Schistosoma mansoni hypothetical protein 0.0064 0.0296 0.0327
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0058 0.0064
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0161 0.3266
Brugia malayi beta-lactamase 0.0082 0.0399 0.0474
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0058 0.0058
Loa Loa (eye worm) MIR domain-containing protein 0.0082 0.0401 0.0593
Echinococcus granulosus Smad4 0.0019 0.0039 0.0042
Schistosoma mansoni hypothetical protein 0.0064 0.0296 0.0327
Brugia malayi Bromodomain containing protein 0.0034 0.0129 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0058 0.0086
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0132 0.0683 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0039 0.0153 0.1592
Onchocerca volvulus 0.0082 0.0399 0.0897
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0347 0.466
Loa Loa (eye worm) hypothetical protein 0.0063 0.0289 0.0427
Echinococcus granulosus tumor protein p63 0.0405 0.2234 0.2473
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0021 0.0053 0.0102
Loa Loa (eye worm) hypothetical protein 0.0202 0.1078 0.1597
Onchocerca volvulus 0.0039 0.0153 0.031
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0016 0.0024 0.0472
Trichomonas vaginalis Phospholipase C precursor, putative 0.0016 0.0024 0.0056
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0058 0.0069
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0108 0.2182
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0053 0.0121
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.0716 0.0851
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0524 0.2909 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0233 0.0344
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0341
Onchocerca volvulus 0.0059 0.027 0.0589
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0058 0.0058
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0016 0.0024 0.0472
Plasmodium vivax exodeoxyribonuclease III, putative 0.0016 0.0024 0.0472
Echinococcus multilocularis beta LACTamase domain containing family member 0.0082 0.0399 0.0399
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0145 0.0144
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0058 0.0064
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0034
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0347 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0058 0.0137
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0058 0.0064
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0021 0.0055 0.0534
Schistosoma mansoni hypothetical protein 0.0668 0.373 0.4129
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0016 0.0024 0.0056
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0108 0.0119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0058 0.0137
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0463 0.1522
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0024 0.0056
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0021 0.0053 0.1068
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0058 0.0058
Brugia malayi CCR4 0.0016 0.0024 0.0028
Leishmania major endonuclease/exonuclease protein-like protein 0.0016 0.0024 0.0141
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0024 0.0472
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0399 0.0949
Toxoplasma gondii histone lysine methyltransferase SET1 0.019 0.1015 1
Onchocerca volvulus 0.0039 0.0153 0.031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.1038 0.1149
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.1038 0.1149
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0034
Schistosoma mansoni stromal cell-derived factor 2 precursor-like protein 0.0082 0.0401 0.0443
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0099 0.0493 1
Trypanosoma brucei RNA editing exonuclease 2 0.0016 0.0024 0.0095
Echinococcus multilocularis neutral sphingomyelinase 0.0016 0.0024 0.0023
Schistosoma mansoni cpg binding protein 0.0102 0.0514 0.0569
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0046 0.0195 0.0231
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0058 0.0058
Echinococcus granulosus cytohesin 1 0.0088 0.0431 0.0477
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0016 0.0024 0.0023
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0064 0.0299 0.606
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0021 0.0053 0.032
Entamoeba histolytica acyl-coA synthetase, putative 0.0132 0.0683 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0053 0.0121
Entamoeba histolytica hypothetical protein 0.0035 0.0132 0.1925
Toxoplasma gondii propionate-CoA ligase 0.0039 0.0153 0.1507
Echinococcus granulosus dnaJ subfamily B 0.1378 0.7761 0.8593
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0024 0.0028
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0053 0.0121
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0176 0.0195
Trichomonas vaginalis importin beta-1, putative 0.0051 0.0222 0.0527
Brugia malayi beta-lactamase family protein 0.0082 0.0399 0.0474
Echinococcus multilocularis deoxyribonuclease 1 2 0.0016 0.0024 0.0023
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0341
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0229
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0021 0.0053 0.1068
Schistosoma mansoni hypothetical protein 0.0138 0.0716 0.0792
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0058 0.0082
Leishmania major importin beta-1 subunit, putative 0.0051 0.0222 0.1345
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0341
Loa Loa (eye worm) hypothetical protein 0.0016 0.0022 0.0031
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0024 0.0095
Trichomonas vaginalis D-aminoacylase, putative 0.0082 0.0399 0.0949
Loa Loa (eye worm) hypothetical protein 0.0079 0.0383 0.0567
Brugia malayi AMP-binding enzyme family protein 0.0132 0.0683 0.0812
Loa Loa (eye worm) hypothetical protein 0.0079 0.0383 0.0567
Leishmania major hypothetical protein, conserved 0.0016 0.0024 0.0141
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0058 0.0069
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0039 0.0153 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0058 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0058 0.0069
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0132 0.0145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0058 0.0086
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0161 0.2359
Schistosoma mansoni Smad4 0.0019 0.0039 0.0042
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0058 0.0064
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0058 0.0064
Mycobacterium tuberculosis Conserved protein 0.0082 0.0399 0.1301
Loa Loa (eye worm) hypothetical protein 0.1116 0.6271 0.9292
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0176 0.0195
Onchocerca volvulus Alhambra homolog 0.0031 0.0108 0.0202
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.078 0.078
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0296 0.0327
Echinococcus granulosus GTP binding nuclear protein Ran 0.0046 0.0195 0.0215
Plasmodium vivax glutathione reductase, putative 0.0061 0.0279 0.5654
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0061 0.0279 0.0885
Echinococcus granulosus muscleblind protein 0.0325 0.178 0.1971
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0202 0.1078 0.1597
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0194 0.1038 0.1234
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0024 0.0095
Brugia malayi glutathione reductase 0.0061 0.0279 0.0332
Leishmania major inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0079 0.0383 0.2329
Echinococcus granulosus microtubule associated protein 2 0.1602 0.9032 1
Echinococcus granulosus ryanodine receptor 44f 0.0376 0.2067 0.2288
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0086
Brugia malayi nuclear receptor NHR-88 0.0022 0.0058 0.0069
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0058 0.0064
Trichomonas vaginalis glutathione reductase, putative 0.0021 0.0053 0.0126
Giardia lamblia NADH oxidase lateral transfer candidate 0.0021 0.0053 0.1066
Schistosoma mansoni hypothetical protein 0.0031 0.0108 0.0119
Leishmania major 4-coumarate:coa ligase-like protein 0.0132 0.0683 0.4153
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0021 0.0055 0.0064
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0024 0.0472
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0132 0.0131
Entamoeba histolytica acyl-CoA synthetase, putative 0.0132 0.0683 1
Toxoplasma gondii exonuclease III APE 0.0064 0.0299 0.2945
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0039 0.0153 0.0449
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0182 0.0433
Echinococcus multilocularis ryanodine receptor 44f 0.0292 0.1589 0.1589
Schistosoma mansoni carbon catabolite repressor protein 0.0016 0.0024 0.0026
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0053 0.0121
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0132 0.0683 0.2285
Brugia malayi AMP-binding enzyme family protein 0.0039 0.0153 0.0182
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0086
Plasmodium falciparum thioredoxin reductase 0.0061 0.0279 0.5654
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0024 0.0028
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0047 0.02 0.0238
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0463 0.1522
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0058 0.0064
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0039 0.0057
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0086
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0153 0.0449
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0058 0.0064
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0229
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0182 0.3686
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0016 0.0024 0.0472
Echinococcus multilocularis stromal cell derived factor 2 0.0082 0.0401 0.04
Plasmodium falciparum acyl-CoA synthetase 0.0099 0.0493 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.027 0.0399
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0506 0.0505
Brugia malayi Importin beta-1 subunit 0.0063 0.0289 0.0343
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0095 0.0474 0.1932
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0058 0.0137
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0064 0.0299 0.0955
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0064 0.0299 0.3907
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0091 0.045 0.0498
Schistosoma mansoni nocturnin 0.0016 0.0024 0.0026
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0058 0.0058
Schistosoma mansoni smad 0.0019 0.0039 0.0042
Trypanosoma cruzi inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0079 0.0383 0.1482
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0202 0.1078 0.1283
Schistosoma mansoni smad1 5 8 and 0.0019 0.0039 0.0042
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0064 0.0299 1
Onchocerca volvulus 0.0082 0.0399 0.0897
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0021 0.0054 0.0126
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0097 0.0482 0.0533
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0153 0.1592
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.0399 0.0441
Schistosoma mansoni cpg binding protein 0.0097 0.0483 0.0534
Schistosoma mansoni hypothetical protein 0.0016 0.0024 0.0026
Brugia malayi phospholipase C homolog 0.0035 0.0134 0.0159
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0347 0.0383
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0039 0.0057
Toxoplasma gondii NADPH-glutathione reductase 0.0021 0.0053 0.0519
Mycobacterium ulcerans beta-lactamase 0.0082 0.0399 0.5492
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0082 0.0399 0.0591
Schistosoma mansoni smad1 5 8 and 0.0019 0.0039 0.0042
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0024 0.0034
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0176 0.0176
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0058 0.0086
Brugia malayi Pre-SET motif family protein 0.0661 0.3689 0.4389
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0058 0.0082
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0039 0.0153 0.1592
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0039 0.0153 0.1507
Brugia malayi hypothetical protein 0.0035 0.0132 0.0156
Loa Loa (eye worm) hypothetical protein 0.0113 0.0574 0.0849
Leishmania major hypothetical protein, conserved 0.0082 0.0399 0.2425
Schistosoma mansoni jumonji domain containing protein 0.008 0.0388 0.0429
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0058 0.0086
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0058 0.0064
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0021 0.0053 0.0058
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0024 0.0034
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0016 0.0024 0.0056
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0153 0.1592
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0153 0.1592
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0024 0.0141
Echinococcus multilocularis cytohesin 1 0.0088 0.0431 0.0431
Loa Loa (eye worm) ryanodine receptor 0.0142 0.0739 0.1094
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0058 0.0069
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0296 0.0351
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0016 0.0024 0.0095
Echinococcus multilocularis GPCR, family 2 0.0064 0.0296 0.0295
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0296 0.0295
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0347 0.1119
Brugia malayi AMP-binding enzyme family protein 0.0039 0.0153 0.0182
Brugia malayi PHD-finger family protein 0.0016 0.0022 0.0025
Leishmania major 4-coumarate:coa ligase-like protein 0.0132 0.0683 0.4153
Mycobacterium leprae conserved hypothetical protein 0.0082 0.0399 0.5492
Echinococcus multilocularis geminin 0.0545 0.3027 0.3027
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0039 0.0153 0.0534
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0058 0.0069
Loa Loa (eye worm) hypothetical protein 0.0082 0.0399 0.0591
Echinococcus granulosus mixed lineage leukemia protein mll 0.0028 0.0089 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0058 0.0137
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0021 0.0053 0.0519
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0082 0.0399 0.1301
Entamoeba histolytica hypothetical protein 0.0035 0.0132 0.1925
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0019 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0086
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0058 0.0069
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0058 0.0064
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0296 0.0351
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0289 0.1177
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0033 0.0123 0.0123
Plasmodium falciparum phd finger protein, putative 0.0031 0.0108 0.2182
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0176 0.0195
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0064 0.0299 0.0299
Entamoeba histolytica MIR domain protein 0.0082 0.0401 0.5865
Toxoplasma gondii ABC1 family protein 0.0082 0.0399 0.3929
Brugia malayi steroid hormone receptor 0.0022 0.0058 0.0069
Mycobacterium ulcerans lipase LipD 0.0082 0.0399 0.5492
Brugia malayi MH2 domain containing protein 0.0019 0.0039 0.0046
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0108 0.106
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0064 0.0299 0.1818
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0039 0.0153 0.0449
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0058 0.0086
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0039 0.0153 0.1592
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0058 0.0064
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0039 0.0153 0.0449
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0024 0.0056
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0021 0.0053 0.0215
Schistosoma mansoni phospholipase C beta 0.0047 0.02 0.0221
Brugia malayi phospholipase C homolog 0.0013 0.0006 0.0007
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.0147 0.0162
Trichomonas vaginalis antibiotic synthetase, putative 0.0039 0.0153 0.0365
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0058 0.0064
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0046 0.0195 0.1917
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0132 0.0683 1
Trichomonas vaginalis ap endonuclease, putative 0.0064 0.0299 0.0711
Onchocerca volvulus 0.0048 0.0207 0.0439
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0048 0.0207 0.0229
Loa Loa (eye worm) hypothetical protein 0.0064 0.0296 0.0437
Plasmodium falciparum thioredoxin reductase 0.0021 0.0053 0.1068
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0182 0.1791
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0058 0.0069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.1038 0.1149
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0024 0.0028
Loa Loa (eye worm) hypothetical protein 0.0132 0.0683 0.1011
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0229
Trypanosoma cruzi trypanothione reductase, putative 0.0061 0.0279 0.1053
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0058 0.0069
Schistosoma mansoni cript-related 0.0016 0.0024 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0153 0.1592
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0097 0.0482 0.0482
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.1038 0.1038
Echinococcus multilocularis muscleblind protein 1 0.0325 0.178 0.178
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0097 0.0482 0.0533
Schistosoma mansoni cpg binding protein 0.0102 0.0514 0.0569
Echinococcus multilocularis muscleblind protein 0.0325 0.178 0.178
Treponema pallidum NADH oxidase 0.0021 0.0053 0.1066
Treponema pallidum exodeoxyribonuclease (exoA) 0.0064 0.0299 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0097 0.0482 0.4749
Trichomonas vaginalis penicillin-binding protein, putative 0.0082 0.0399 0.0949
Brugia malayi AMP-binding enzyme family protein 0.0132 0.0683 0.0812
Schistosoma mansoni hypothetical protein 0.0035 0.0132 0.0145
Brugia malayi Pre-SET motif family protein 0.0097 0.0482 0.0573
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0024 0.0028
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0024 0.0095
Brugia malayi PHD-finger family protein 0.0031 0.0108 0.0128
Loa Loa (eye worm) hypothetical protein 0.0039 0.0153 0.0227
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0016 0.0024 0.0341
Echinococcus granulosus mothers against decapentaplegic 5 0.0019 0.0039 0.0042
Mycobacterium leprae Probable lipase LipE 0.0082 0.0399 0.5492
Loa Loa (eye worm) hypothetical protein 0.0082 0.0399 0.0591
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0222 0.0527
Leishmania major pantothenate kinase subunit, putative 0.0021 0.0054 0.0328
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0058 0.0069
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0016 0.0024 0.0056
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0443 0.245 1
Leishmania major acetyl-CoA synthetase, putative 0.0039 0.0153 0.093
Schistosoma mansoni synaptojanin 0.0016 0.0024 0.0026
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0039 0.0153 0.0153
Mycobacterium ulcerans acyl-CoA synthetase 0.0039 0.0153 0.1592
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0182 0.1791
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0016 0.0024 0.0034
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0039 0.0153 0.224
Plasmodium falciparum DNase I-like protein, putative 0.0016 0.0024 0.0472
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0016 0.0024 0.0023
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0108 0.0108
Echinococcus granulosus cpg binding protein 0.0102 0.0514 0.0569
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0176 0.0195
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0033 0.0123 0.0136
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0347 0.3412
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0064 0.0299 0.122
Echinococcus multilocularis smad 0.0019 0.0039 0.0038
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0046 0.0195 0.0288
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0016 0.0024 0.0026
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0108 0.0159
Echinococcus multilocularis tumor protein p63 0.0405 0.2234 0.2233
Leishmania major hypothetical protein, conserved 0.0016 0.0024 0.0141
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0058 0.0086
Onchocerca volvulus 0.0082 0.0401 0.0901
Trichomonas vaginalis mannosyltransferase 1, putative 0.0082 0.0401 0.0953
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0082 0.0399 0.0441
Leishmania major phosphoinositide-specific phospholipase C, putative 0.002 0.0048 0.0288
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0039 0.0153 0.0182
Plasmodium vivax phospholipase C-like, putative 0.002 0.0048 0.0959
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0021 0.0053 0.032
Loa Loa (eye worm) hypothetical protein 0.0082 0.0399 0.0591
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0039 0.0153 0.0624
Echinococcus multilocularis importin subunit beta 1 0.0063 0.0289 0.0288
Entamoeba histolytica hypothetical protein 0.0035 0.0132 0.1925
Loa Loa (eye worm) hypothetical protein 0.0097 0.0482 0.0714
Loa Loa (eye worm) hypothetical protein 0.0082 0.0399 0.0591
Trypanosoma brucei hypothetical protein, conserved 0.0082 0.0399 0.1627
Schistosoma mansoni acetyl-CoA synthetase 0.0039 0.0153 0.0169
Schistosoma mansoni importin beta-1 0.0063 0.0289 0.0319
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0016 0.0024 0.0026
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0046 0.0195 0.3945
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0039 0.0153 0.1592
Brugia malayi Muscleblind-like protein 0.0325 0.178 0.2118
Mycobacterium ulcerans acetyl-CoA synthetase 0.0039 0.0153 0.1592
Leishmania major phospholipase c-like protein 0.0021 0.0055 0.033
Schistosoma mansoni ran 0.0046 0.0195 0.0215
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0024 0.0023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0032 0.0035
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0064 0.0299 0.606
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0229
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0661 0.3689 0.5466
Echinococcus granulosus TGF beta signal transducer SmadC 0.0019 0.0039 0.0042
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0021 0.0053 0.0102
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0058 0.0137
Trypanosoma cruzi inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0079 0.0383 0.1482
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0024 0.0341
Loa Loa (eye worm) hypothetical protein 0.0099 0.0493 0.073
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0077 0.0373 0.0412
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0058 0.0069
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0019 0.0039 0.0042
Brugia malayi Cytohesin 3 0.0088 0.0431 0.0512
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0021 0.0053 0.0215
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0058 0.0069
Loa Loa (eye worm) thioredoxin reductase 0.0061 0.0279 0.0413
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0016 0.0024 0.0472
Echinococcus granulosus stromal cell derived factor 2 0.0082 0.0401 0.0443
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0021 0.0053 0.1068
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0132 0.0145
Brugia malayi Variant SH3 domain containing protein 0.0024 0.007 0.0082
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0153 0.0449
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.0463 0.1522
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0039 0.0153 0.0449
Loa Loa (eye worm) hypothetical protein 0.119 0.6694 0.9919
Brugia malayi MH1 domain containing protein 0.0019 0.0039 0.0046
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0021 0.0053 0.0102
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0024 0.0056
Echinococcus granulosus GPCR family 2 0.0064 0.0296 0.0327
Brugia malayi AMP-binding enzyme family protein 0.0039 0.0153 0.0182
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0153 0.0449
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0046 0.0195 0.0195
Giardia lamblia PHD finger protein 15 0.0031 0.0108 0.306
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0058 0.0137
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0039 0.0153 0.0449
Schistosoma mansoni ryanodine receptor 1 skeletal muscle 0.0142 0.0739 0.0818
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0024 0.0034
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0347 0.0383
Plasmodium vivax thioredoxin reductase, putative 0.0061 0.0279 0.5654
Schistosoma mansoni neutral sphingomyelinase 0.0016 0.0024 0.0026
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0289 0.1177
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0021 0.0023
Loa Loa (eye worm) Smad1 0.0019 0.0039 0.0057
Loa Loa (eye worm) hypothetical protein 0.0082 0.0399 0.0591
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0058 0.0137
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0195 0.0706
Brugia malayi MH2 domain containing protein 0.0273 0.1484 0.1765
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0053 0.0121
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0082 0.0399 0.1301
Loa Loa (eye worm) hypothetical protein 0.0082 0.0399 0.0591
Brugia malayi Thioredoxin reductase 0.0061 0.0279 0.0332
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0194 0.1038 0.1537
Brugia malayi nuclear hormone receptor 0.0022 0.0058 0.0069
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0024 0.0028
Trichomonas vaginalis antibiotic synthetase, putative 0.0039 0.0153 0.0365
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0021 0.0021
Plasmodium falciparum glutathione reductase 0.0061 0.0279 0.5654
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0064 0.0299 0.0443
Schistosoma mansoni ryanodine receptor related 0.0525 0.2917 0.323
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.078 0.0863
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0058 0.0069
Loa Loa (eye worm) cytohesin 3 0.0088 0.0431 0.0638
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0021 0.0055 0.0221
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0086
Echinococcus granulosus synaptojanin 1 0.0016 0.0024 0.0026
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0024 0.0229
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0132 0.0683 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0064 0.0299 0.1135
Mycobacterium tuberculosis Conserved protein 0.0082 0.0399 0.1301
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0058 0.0064

Activities

Activity type Activity value Assay description Source Reference
Diuretic activity (ADMET) = 100 Compound administered intravenously was evaluated for salidiuretic activity measured as sodium ion excretion in Dog; Value ranges from 100-249 ChEMBL. 7452697

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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