Detailed information for compound 504695

Basic information

Technical information
  • TDR Targets ID: 504695
  • Name: N-(2-aminophenyl)-4-[2-(naphthalen-2-ylamino) -2-oxo-1-(4-phenylpiperazin-1-yl)ethyl]benzam ide
  • MW: 555.669 | Formula: C35H33N5O2
  • H donors: 3 H acceptors: 2 LogP: 5.86 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(C(c1ccc(cc1)C(=O)Nc1ccccc1N)N1CCN(CC1)c1ccccc1)Nc1ccc2c(c1)cccc2
  • InChi: 1S/C35H33N5O2/c36-31-12-6-7-13-32(31)38-34(41)27-16-14-26(15-17-27)33(40-22-20-39(21-23-40)30-10-2-1-3-11-30)35(42)37-29-19-18-25-8-4-5-9-28(25)24-29/h1-19,24,33H,20-23,36H2,(H,37,42)(H,38,41)
  • InChiKey: WPBSNVTXKCFCIY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-aminophenyl)-4-[2-(2-naphthylamino)-2-oxo-1-(4-phenylpiperazin-1-yl)ethyl]benzamide
  • N-(2-aminophenyl)-4-[2-(2-naphthalenylamino)-2-oxo-1-(4-phenyl-1-piperazinyl)ethyl]benzamide
  • N-(2-aminophenyl)-4-[2-keto-2-(2-naphthylamino)-1-(4-phenylpiperazino)ethyl]benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.03 0.1392 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0044 0.0552
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0106 0.057
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.002 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0086
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0033 0.0337
Loa Loa (eye worm) hypothetical protein 0.005 0.0175 0.0591
Echinococcus granulosus thyroid hormone receptor alpha 0.005 0.0175 0.0175
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Onchocerca volvulus 0.0107 0.045 0.4156
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0256 0.0864
Loa Loa (eye worm) nuclear receptor nhr-7B 0.005 0.0175 0.0591
Echinococcus multilocularis solute carrier family 22 0.002 0.0025 0.0239
Brugia malayi nuclear receptor NHR-88 0.0107 0.045 0.1517
Schistosoma mansoni nuclear hormone receptor 0.005 0.0175 0.0946
Loa Loa (eye worm) hypothetical protein 0.0098 0.0407 0.1373
Loa Loa (eye worm) hypothetical protein 0.0107 0.045 0.1517
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0288 0.2713
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0178 0.3392
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0459 0.1546
Brugia malayi Death domain containing protein 0.0014 0.000000010137 0.00000003416
Brugia malayi nuclear receptor NHR-67 0.005 0.0175 0.0591
Trypanosoma cruzi sugar transporter, putative 0.002 0.0025 0.0409
Schistosoma mansoni glucose transport protein 0.002 0.0025 0.0137
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0055
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.002 0.0025 0.0025
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0107 0.045 0.4236
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0146 0.0146
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.0647 0.2179
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0022 0.0039
Loa Loa (eye worm) hypothetical protein 0.0107 0.045 0.1517
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.03 0.1392 1
Schistosoma mansoni hypothetical protein 0.0068 0.0262 0.1414
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0105 0.0987
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.004 0.0214
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0107 0.045 0.4236
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0029
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0942 0.3176
Leishmania major UDP-galactopyranose mutase 0.0021 0.0033 0.0559
Brugia malayi orphan nuclear receptor NR2E1 0.005 0.0175 0.0591
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0073 0.1039
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.012 0.0516 0.2782
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0039 0.0119 0.223
Leishmania major glucose transporter, lmgt3 0.002 0.0025 0.0409
Echinococcus multilocularis Sugar transporter ERD6 protein 0.002 0.0025 0.0239
Loa Loa (eye worm) hypothetical protein 0.005 0.0175 0.0591
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0395 0.1854 1
Schistosoma mansoni nuclear receptor 0.005 0.0175 0.0946
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0178 0.0178
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.0647 0.3488
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0225 0.4125
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0149 0.2656
Echinococcus granulosus fatty acid binding protein FABP2 0.0067 0.0257 0.0257
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0045 0.0153
Leishmania major glucose transporter, lmgt1 0.002 0.0025 0.0409
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0019 0.0021 0.0077
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0251 0.4825
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0029
Entamoeba histolytica hypothetical protein 0.0038 0.0115 0.0706
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0146 0.049
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0073 0.1039
Brugia malayi Sugar transporter family protein 0.002 0.0025 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0197 0.0891 0.4806
Trypanosoma brucei glucose transporter, putative 0.002 0.0025 0.0409
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0107 0.045 0.4236
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0146 0.0785
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0459 0.4318
Loa Loa (eye worm) hypothetical protein 0.0067 0.0256 0.0864
Toxoplasma gondii ATP-citrate lyase, putative 0.0053 0.019 0.3405
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0459 0.0459
Brugia malayi bZIP transcription factor family protein 0.0084 0.0339 0.1141
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0075 0.0406
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0049 0.0867
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0178 0.1675
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0149 0.0149
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0225 0.0225
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0107 0.045 0.2428
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Brugia malayi photoreceptor-specific nuclear receptor 0.0107 0.045 0.1517
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0067 0.0928
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0178 0.0178
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0279 0.1289 1
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0044 0.0769
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0086
Echinococcus multilocularis fatty acid binding protein FABP2 0.0205 0.0929 0.8742
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0205 0.069
Trichomonas vaginalis sensor histidine kinase, putative 0.0024 0.0048 0.02
Schistosoma mansoni nuclear receptor 0.005 0.0175 0.0946
Echinococcus multilocularis fatty acid binding protein FABP2 0.0067 0.0257 0.2423
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0111
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Echinococcus granulosus lamin 0.0027 0.0061 0.0061
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0013 0.0013
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0459 0.8886
Echinococcus granulosus lamin dm0 0.0027 0.0061 0.0061
Brugia malayi Major Facilitator Superfamily protein 0.002 0.0025 0.0086
Trypanosoma brucei THT1 - hexose transporter, putative 0.002 0.0025 0.0409
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0225 0.152
Trypanosoma brucei protein kinase, putative 0.0051 0.0178 0.3392
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0044 0.8385
Onchocerca volvulus Bile acid receptor homolog 0.0107 0.045 0.4156
Trypanosoma cruzi UDP-glucoronosyl and UDP-glucosyl transferase, putative 0.0026 0.0056 0.1003
Brugia malayi nuclear hormone receptor family member odr-7 0.005 0.0175 0.0591
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0225 0.2122
Loa Loa (eye worm) hypothetical protein 0.0107 0.045 0.1517
Toxoplasma gondii sugar transporter ST1 0.002 0.0025 0.0077
Brugia malayi hypothetical protein 0.0038 0.0115 0.0389
Schistosoma mansoni intermediate filament proteins 0.0027 0.0061 0.033
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.002 0.0025 0.0025
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0107 0.045 0.2428
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0251 0.2364
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.002 0.0025 0.0066
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0251 0.4825
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.004 0.004
Onchocerca volvulus 0.002 0.0025 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0107 0.045 0.1517
Echinococcus granulosus synaptic vesicle 2 protein 0.002 0.0025 0.0025
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0081 0.0081
Loa Loa (eye worm) lipocalin/cytosolic fatty-acid binding protein family protein 0.0623 0.2967 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0327 0.1103
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Brugia malayi Lipocalin / cytosolic fatty-acid binding protein family protein 0.0623 0.2967 1
Brugia malayi Nuclear hormone receptor E75 0.005 0.0175 0.0591
Toxoplasma gondii histone lysine-specific demethylase 0.0021 0.0033 0.0233
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0178 0.3392
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0024 0.0048 0.02
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0022 0.0078
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0013 0.007
Brugia malayi Bromodomain containing protein 0.0078 0.0312 0.1052
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.000000010137 0.000000010137
Schistosoma mansoni thyroid hormone receptor 0.0232 0.1062 0.5731
Schistosoma mansoni nuclear hormone receptor 0.005 0.0175 0.0946
Echinococcus multilocularis lamin 0.0027 0.0061 0.0576
Onchocerca volvulus 0.002 0.0025 0.0234
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0013 0.007
Leishmania major myo-inositol/proton symporter (MIT) 0.002 0.0025 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0107 0.045 0.1517
Loa Loa (eye worm) hypothetical protein 0.0024 0.0049 0.0164
Onchocerca volvulus 0.002 0.0025 0.0234
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0021 0.0033 0.0311
Schistosoma mansoni coup transcription factor 0.0107 0.045 0.2428
Trypanosoma brucei glucose transporter 2A 0.002 0.0025 0.0409
Trypanosoma brucei glucose transporter, putative 0.002 0.0025 0.0409
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.1352 1
Brugia malayi 6-phosphofructokinase 0.0108 0.0459 0.1546
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.0647 0.6086
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.0625 0.4797
Brugia malayi phosphofructokinase 0.0108 0.0459 0.1546
Trypanosoma cruzi hexose transporter 0.002 0.0025 0.0409
Brugia malayi TAR-binding protein 0.0197 0.0891 0.3002
Echinococcus granulosus solute carrier family 22 0.002 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0086
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.038 0.3575
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0225 0.1674
Schistosoma mansoni tar DNA-binding protein 0.0197 0.0891 0.4806
Brugia malayi Sugar transporter family protein 0.002 0.0025 0.0086
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0022 0.0334
Loa Loa (eye worm) hypothetical protein 0.0056 0.0205 0.069
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0044 0.0552
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0044 0.02
Loa Loa (eye worm) hypothetical protein 0.0083 0.0334 0.1127
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0056 0.0205 0.1927
Echinococcus multilocularis Nuclear hormone receptor HR96 0.005 0.0175 0.1651
Brugia malayi MAP kinase sur-1 0.0051 0.0178 0.06
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0049 0.0552
Loa Loa (eye worm) hypothetical protein 0.0146 0.0642 0.2163
Brugia malayi nuclear hormone receptor family member nhr-6 0.005 0.0175 0.0591
Loa Loa (eye worm) hypothetical protein 0.0028 0.0067 0.0227
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0033 0.0112
Entamoeba histolytica hypothetical protein 0.0038 0.0115 0.0706
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0107 0.045 0.1517
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0022 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.1352 1
Echinococcus granulosus fatty acid binding protein FABP2 0.0205 0.0929 0.0929
Onchocerca volvulus 0.0027 0.0061 0.0566
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.000000010137 0.000000054684
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.007 0.007
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0459 0.2475
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0045 0.0212
Schistosoma mansoni ATP-citrate synthase 0.0045 0.015 0.081
Echinococcus granulosus solute carrier family 22 0.002 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0056 0.0205 0.069
Loa Loa (eye worm) hypothetical protein 0.0107 0.045 0.1517
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0107 0.045 0.1517
Trypanosoma brucei THT1 - hexose transporter, putative 0.002 0.0025 0.0409
Echinococcus granulosus peregrin 0.0034 0.0096 0.0096
Onchocerca volvulus 0.002 0.0025 0.0234
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0334 0.1804
Onchocerca volvulus 0.002 0.0025 0.0234
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0078 0.0313 0.5889
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0078 0.0313 0.2153
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0056 0.0205 0.0205
Mycobacterium ulcerans dehydrogenase 0.0021 0.0033 0.0122
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0107 0.045 0.045
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.012 0.0516 0.3715
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0045 0.0179
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Schistosoma mansoni hypothetical protein 0.0031 0.0081 0.0437
Schistosoma mansoni zinc finger protein 0.005 0.0175 0.0946
Echinococcus granulosus Nuclear hormone receptor HR96 0.005 0.0175 0.0175
Echinococcus multilocularis GPCR, family 2 0.0031 0.0081 0.0763
Onchocerca volvulus Protein ultraspiracle homolog 0.0107 0.045 0.4156
Trichomonas vaginalis glucose transporter, putative 0.002 0.0025 0.0029
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0022 0.0203
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0111
Brugia malayi nuclear receptor NHR-88 0.005 0.0175 0.0591
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0045 0.08
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0045 0.0212
Schistosoma mansoni amine oxidase 0.0021 0.0033 0.0178
Echinococcus multilocularis fatty acid binding protein FABP2 0.0205 0.0929 0.8742
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0073 0.0386
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0022 0.0334
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.002 0.0025 0.0137
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0086
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0225 0.4321
Brugia malayi Major Facilitator Superfamily protein 0.002 0.0025 0.0086
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.002 0.0025 0.0239
Echinococcus multilocularis Nuclear hormone receptor HR96 0.005 0.0175 0.1651
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0056 0.0205 0.1105
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0022 0.0106
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0372 0.1252
Onchocerca volvulus 0.002 0.0025 0.0234
Brugia malayi Major Facilitator Superfamily protein 0.002 0.0025 0.0086
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0106 0.057
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0238 0.0238
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0073 0.1135
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0149 0.0957
Trypanosoma cruzi hexose transporter, putative 0.002 0.0025 0.0409
Brugia malayi hypothetical protein 0.002 0.0025 0.0086
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0459 0.3287
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0019 0.0021 0.0037
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0019 0.0021 0.0037
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0021 0.0033 0.0337
Loa Loa (eye worm) sugar transporter 0.002 0.0025 0.0086
Loa Loa (eye worm) hypothetical protein 0.0056 0.0205 0.069
Schistosoma mansoni tar DNA-binding protein 0.0197 0.0891 0.4806
Brugia malayi Sugar transporter family protein 0.002 0.0025 0.0086
Onchocerca volvulus 0.002 0.0025 0.0234
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0115 0.1086
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0178 0.1675
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0225 0.152
Schistosoma mansoni lamin 0.0027 0.0061 0.033
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0073 0.0386
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Brugia malayi tailless protein 0.005 0.0175 0.0591
Echinococcus granulosus Ankyrin 0.0014 0.0001 0.0001
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0086
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Brugia malayi Nuclear hormone receptor-like 1 0.0107 0.045 0.1517
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0107 0.045 0.1517
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0288 0.0288
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0067 0.0928
Onchocerca volvulus 0.005 0.0175 0.1619
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0107 0.045 0.1517
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0107 0.045 0.045
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0044 0.045
Echinococcus multilocularis ecdysone induced protein 78C 0.0107 0.045 0.4236
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0049 0.0652
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0107 0.045 0.1517
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0086
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0061 0.0206
Brugia malayi jmjC domain containing protein 0.0036 0.0106 0.0356
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0146 0.137
Loa Loa (eye worm) tyrosinase 1 0.0091 0.0372 0.1252
Loa Loa (eye worm) hypothetical protein 0.0056 0.0205 0.069
Schistosoma mansoni hypothetical protein 0.0031 0.0081 0.0437
Loa Loa (eye worm) leucine Rich Repeat family protein 0.004 0.0126 0.0426
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0045 0.08
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0146 0.0146
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0107 0.045 0.045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0158 0.0854
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.005 0.0175 0.1651
Echinococcus multilocularis peregrin 0.0034 0.0096 0.0905
Brugia malayi SWIRM domain containing protein 0.0021 0.0033 0.0111
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0158 0.0158
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0044 0.045
Loa Loa (eye worm) acetyltransferase 0.0147 0.0647 0.2179
Schistosoma mansoni sugar transporter 0.002 0.0025 0.0137
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0055
Mycobacterium ulcerans monoamine oxidase 0.0021 0.0033 0.0122
Brugia malayi hypothetical protein 0.0066 0.0251 0.0845
Brugia malayi nuclear receptor RXR 0.0056 0.0205 0.069
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0107 0.045 0.1517
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0073 0.1135
Giardia lamblia Fructose-bisphosphate aldolase 0.0292 0.1352 1
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.012 0.0516 0.0516
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0459 0.8886
Echinococcus multilocularis solute carrier family 22 0.002 0.0025 0.0239
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0086
Brugia malayi amine oxidase, flavin-containing family protein 0.0021 0.0033 0.0111
Loa Loa (eye worm) RNA binding protein 0.0197 0.0891 0.3002
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0013 0.0123
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0019 0.0021 0.0037
Loa Loa (eye worm) hypothetical protein 0.005 0.0175 0.0591
Echinococcus granulosus Nuclear hormone receptor HR96 0.005 0.0175 0.0175
Trichomonas vaginalis set domain proteins, putative 0.0236 0.1082 0.7974
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0334 0.0334
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0001 0.0003
Treponema pallidum methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-2) 0.0528 0.2507 1
Brugia malayi Protein kinase domain containing protein 0.0015 0.0002 0.0008
Onchocerca volvulus 0.003 0.0075 0.0695
Schistosoma mansoni ap endonuclease 0.0019 0.0022 0.0116
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0086
Loa Loa (eye worm) major facilitator superfamily transporter 0.002 0.0025 0.0086
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0081 0.0081
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0178 0.1176
Mycobacterium tuberculosis Possible oxidoreductase 0.0021 0.0033 0.0168
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0459 0.3287
Schistosoma mansoni thyroid hormone receptor 0.0232 0.1062 0.5731
Schistosoma mansoni tar DNA-binding protein 0.0197 0.0891 0.4806
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0055
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0019 0.0021 0.0077
Trypanosoma brucei glucose transporter, putative 0.002 0.0025 0.0409
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0459 0.3216
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.012 0.208
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0019 0.0021 0.0102
Onchocerca volvulus 0.002 0.0025 0.0234
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0073 0.0386
Trypanosoma cruzi glucose transporter, putative 0.002 0.0025 0.0409
Schistosoma mansoni nuclear receptor nhr-48 0.005 0.0175 0.0946
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Brugia malayi jmjC domain containing protein 0.0092 0.038 0.128
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0107 0.045 0.4236
Brugia malayi ATP-citrate synthase 0.0053 0.019 0.064
Loa Loa (eye worm) hypothetical protein 0.0071 0.0274 0.0924
Leishmania major hypothetical protein, conserved 0.002 0.0025 0.0409
Schistosoma mansoni zinc finger protein 0.0023 0.0043 0.023
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0459 0.1546
Onchocerca volvulus 0.002 0.0025 0.0234
Echinococcus multilocularis lamin dm0 0.0027 0.0061 0.0576
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0049 0.0652
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0073 0.0386
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0178 0.1176
Schistosoma mansoni hypothetical protein 0.0021 0.003 0.0164
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0111
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0107 0.045 0.045
Trichomonas vaginalis myo-inositol transporter, putative 0.002 0.0025 0.0029
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.005 0.0175 0.0946
Loa Loa (eye worm) hypothetical protein 0.0026 0.0059 0.0198
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0024 0.0048 1
Brugia malayi RNA recognition motif domain containing protein 0.0197 0.0891 0.3002
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0024 0.0048 0.02
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.012 0.0516 0.1738
Brugia malayi hypothetical protein 0.0056 0.0205 0.069
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.005 0.0175 0.1619
Loa Loa (eye worm) hypothetical protein 0.0027 0.0061 0.0206
Mycobacterium ulcerans integral membrane transport protein 0.002 0.0025 0.0066
Schistosoma mansoni sugar transporter 0.002 0.0025 0.0137
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0407 0.1373
Echinococcus granulosus ecdysone induced protein 78C 0.0107 0.045 0.045
Echinococcus granulosus solute carrier family 22 0.002 0.0025 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0107 0.045 0.1517
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0073 0.0386
Trypanosoma cruzi hexose transporter, putative 0.002 0.0025 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0029
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0459 0.176
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0149 0.2577
Echinococcus multilocularis protoporphyrinogen oxidase 0.0021 0.0033 0.0311
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0073 0.1135
Loa Loa (eye worm) hypothetical protein 0.005 0.0175 0.0591
Brugia malayi hypothetical protein 0.002 0.0025 0.0086
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0045 0.0265
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0061 0.0206
Schistosoma mansoni hypothetical protein 0.0031 0.0081 0.0437
Brugia malayi ecdysone receptor 0.005 0.0175 0.0591
Loa Loa (eye worm) hypothetical protein 0.0046 0.0155 0.0522
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0021 0.0033 0.0178
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0021 0.0033 0.0178
Loa Loa (eye worm) hypothetical protein 0.005 0.0175 0.0591
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.002 0.0025 0.0409
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0045 0.0097
Onchocerca volvulus 0.0027 0.0061 0.0566
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0251 0.1355
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0175 0.1651
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0021 0.0033 0.0233
Entamoeba histolytica hypothetical protein 0.0038 0.0115 0.0706
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0021 0.0033 0.0337
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0111
Brugia malayi nuclear receptor RXR 0.005 0.0175 0.0591
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0178 0.1176
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0033 0.0559
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0214 0.072
Brugia malayi hypothetical protein 0.005 0.0175 0.0591
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0086
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0049 0.0867
Schistosoma mansoni lamin 0.0027 0.0061 0.033
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.002 0.0025 0.0108
Plasmodium vivax sugar transporter, putative 0.002 0.0025 0.0183
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0107 0.045 0.1517
Trypanosoma brucei glucose transporter 1E 0.002 0.0025 0.0409
Schistosoma mansoni hypothetical protein 0.0067 0.0256 0.1383
Loa Loa (eye worm) DR-78 0.005 0.0175 0.0591
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.002 0.0025 0.0239
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Entamoeba histolytica hypothetical protein 0.0023 0.0044 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0029
Echinococcus granulosus solute carrier family 22 0.002 0.0025 0.0025
Treponema pallidum fructose-bisphosphate aldolase 0.0292 0.1352 0.5353
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0044 0.0253
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0175 0.0175
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0107 0.045 0.045
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0111
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.038 0.038
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0019 0.0021 0.0077
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0021 0.0033 0.0337
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0091 0.0372 0.1252
Trypanosoma cruzi hexose transporter, putative 0.002 0.0025 0.0409
Loa Loa (eye worm) hypothetical protein 0.0107 0.045 0.1517
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0459 0.176
Brugia malayi Nuclear hormone receptor E75 0.005 0.0175 0.0591
Schistosoma mansoni hypothetical protein 0.0052 0.0182 0.098
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0657 0.6181
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.003 0.0103
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0045 0.08
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0146 0.137
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0251 0.0251
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.1352 1
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0044 0.0091
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0045 0.0097
Trypanosoma brucei sugar transporter, putative 0.002 0.0025 0.0409
Schistosoma mansoni bromodomain containing protein 0.0067 0.0255 0.1376
Onchocerca volvulus 0.0236 0.1083 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.0045 0.0212
Echinococcus multilocularis synaptic vesicle 2 protein 0.002 0.0025 0.0239
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0251 0.1726
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0107 0.045 0.2428
Brugia malayi Muscleblind-like protein 0.0149 0.0657 0.2213
Brugia malayi hypothetical protein 0.002 0.0025 0.0086
Trypanosoma cruzi hexose transporter, putative 0.002 0.0025 0.0409
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0049 0.0867
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0086
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0045 0.0212
Mycobacterium ulcerans sugar transporter 0.002 0.0025 0.0066
Schistosoma mansoni steroid hormone receptor ad4bp 0.0107 0.045 0.2428
Trypanosoma brucei glucose transporter, putative 0.002 0.0025 0.0409
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0459 0.35
Loa Loa (eye worm) hypothetical protein 0.005 0.0175 0.0591
Onchocerca volvulus 0.0021 0.0033 0.0305
Plasmodium falciparum protoporphyrinogen oxidase 0.0021 0.0033 0.0337
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0084 0.0339 0.3187
Loa Loa (eye worm) hypothetical protein 0.005 0.0175 0.0591
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0021 0.0033 0.0122
Schistosoma mansoni hypothetical protein 0.0169 0.0754 0.4069
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0459 0.3287
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0073 0.0386
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0073 0.1135
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0067 0.0227
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.002 0.0025 0.0183
Loa Loa (eye worm) nuclear receptor NHR-67 0.005 0.0175 0.0591
Echinococcus multilocularis FTZ F1 alpha 0.0107 0.045 0.4236
Toxoplasma gondii sugar transporter ST2 0.002 0.0025 0.0077
Schistosoma mansoni jun-related protein 0.0068 0.0262 0.1414
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Schistosoma mansoni hypothetical protein 0.0031 0.0081 0.0437
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0407 0.1373
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.1352 1
Schistosoma mansoni tyrosinase precursor 0.0091 0.0372 0.2004
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.002 0.0025 0.1511
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.0615 0.0615
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.012 0.0516 1
Schistosoma mansoni nuclear hormone receptor 0.0107 0.045 0.2428
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0044 0.02
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0021 0.0033 0.0047
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.002 0.0025 0.0239
Toxoplasma gondii facilitative glucose transporter GT1 0.002 0.0025 0.0077
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.005 0.0175 0.1619
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0029
Onchocerca volvulus 0.0146 0.0642 0.5928
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0287 0.155
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0251 0.0846
Echinococcus multilocularis solute carrier family 22 0.002 0.0025 0.0239
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0178 0.06
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Loa Loa (eye worm) hypothetical protein 0.0107 0.045 0.1517
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0045 0.0153
Schistosoma mansoni glucose transport protein 0.002 0.0025 0.0137
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0073 0.1135
Schistosoma mansoni sugar transporter 0.002 0.0025 0.0137
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.012 0.0741
Schistosoma mansoni hypothetical protein 0.0126 0.0542 0.2926
Echinococcus multilocularis Ankyrin 0.0014 0.0001 0.0006
Schistosoma mansoni hypothetical protein 0.002 0.0025 0.0137
Brugia malayi major facilitator superfamily protein 0.002 0.0025 0.0086
Loa Loa (eye worm) TAR-binding protein 0.0197 0.0891 0.3002
Schistosoma mansoni sugar transporter 0.002 0.0025 0.0137
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0045 0.0179
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0019 0.0021 0.0037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.1352 1
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.012 0.0516 1
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0084 0.0339 0.0339
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.012 0.0516 0.3715
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0178 0.1176
Schistosoma mansoni fatty acid binding protein 0.0205 0.0929 0.501
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0106 0.0106
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.1352 1
Brugia malayi Pre-SET motif family protein 0.003 0.0075 0.0254
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0045 0.0212
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.012 0.0516 0.363
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0056 0.0205 0.1105
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0107 0.045 0.1517
Loa Loa (eye worm) hypothetical protein 0.0149 0.0657 0.2213
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0075 0.0406
Brugia malayi RNA binding protein 0.0197 0.0891 0.3002
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.012 0.0516 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0459 0.1546
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0024 0.0048 0.02
Loa Loa (eye worm) hypothetical protein 0.0091 0.0372 0.1252
Echinococcus granulosus FTZ F1 alpha 0.0107 0.045 0.045
Trichomonas vaginalis receptor histidine kinase, putative 0.0024 0.0048 0.02
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0022 0.0334
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0146 0.049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0107 0.045 0.1517
Echinococcus multilocularis muscleblind protein 0.0149 0.0657 0.6181
Trichomonas vaginalis receptor histidine kinase, putative 0.0024 0.0048 0.02
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.1352 1
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Echinococcus multilocularis jun protein 0.0084 0.0339 0.3187
Schistosoma mansoni ap endonuclease 0.0019 0.0022 0.0116
Onchocerca volvulus 0.0024 0.0045 0.0419
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0055
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0073 0.1135
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0178 0.3164
Brugia malayi Bromodomain containing protein 0.0034 0.0096 0.0324
Mycobacterium ulcerans oxidoreductase 0.0021 0.0033 0.0122
Loa Loa (eye worm) major facilitator superfamily transporter 0.002 0.0025 0.0086
Loa Loa (eye worm) hypothetical protein 0.0107 0.045 0.1517
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0107 0.045 0.2428
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0042 0.0133 0.0952
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.002 0.0025 0.0066
Echinococcus multilocularis musashi 0.0027 0.0061 0.0576
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0107 0.045 0.1517
Loa Loa (eye worm) ATP-citrate synthase 0.0053 0.019 0.064
Onchocerca volvulus 0.002 0.0025 0.0234
Loa Loa (eye worm) hypothetical protein 0.0107 0.045 0.1517
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0019 0.0021 0.0077
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0002
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0067 0.0634
Chlamydia trachomatis protoporphyrinogen oxidase 0.0021 0.0033 0.0337
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.012 0.0516 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.0542 0.5106
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0021 0.0033 0.0337
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0019 0.0021 0.0077
Schistosoma mansoni glucose transporter 0.002 0.0025 0.0137
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0121 0.0121
Trichomonas vaginalis glucose transporter, putative 0.002 0.0025 0.0029
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0081 0.0763
Loa Loa (eye worm) hypothetical protein 0.0149 0.0657 0.2213
Leishmania major hypothetical protein, conserved 0.0024 0.0049 0.0867
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0044 0.0769
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.012 0.0516 1
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0121 0.1141
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.005 0.0175 0.0175
Loa Loa (eye worm) ShTK domain-containing protein 0.0091 0.0372 0.1252
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0081 0.0273
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0067 0.1024
Onchocerca volvulus 0.0091 0.0372 0.3431
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0107 0.045 0.4236
Leishmania major glucose transporter, lmgt2 0.002 0.0025 0.0409
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.0542 0.0542
Echinococcus multilocularis solute carrier family 22 0.002 0.0025 0.0239
Echinococcus granulosus jun protein 0.0084 0.0339 0.0339
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0205 0.069
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.002 0.0025 0.0239
Schistosoma mansoni amine oxidase 0.0021 0.0033 0.0178
Echinococcus granulosus geminin 0.0169 0.0754 0.0754
Echinococcus granulosus tar DNA binding protein 0.0197 0.0891 0.0891
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0044 0.009
Loa Loa (eye worm) hypothetical protein 0.0091 0.0372 0.1252
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0086
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.012 0.0516 1
Brugia malayi ecdysteroid receptor 0.0107 0.045 0.1517
Brugia malayi Pre-SET motif family protein 0.0208 0.0942 0.3176
Echinococcus granulosus nuclear receptor nhr 48 0.005 0.0175 0.0175
Schistosoma mansoni hypothetical protein 0.0028 0.0067 0.0364
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0251 0.0846
Loa Loa (eye worm) hypothetical protein 0.0024 0.0045 0.0153
Onchocerca volvulus 0.002 0.0025 0.0234
Echinococcus granulosus fatty acid binding protein, adipocyte 0.0067 0.0257 0.0257
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.012 0.0516 0.3715
Brugia malayi conserved hypotetical protein 0.005 0.0175 0.0591
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0251 0.4825
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0459 0.3287
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0158 0.0854
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0334 0.1127
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0081 0.0273
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0178 0.3392
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0033 0.0168
Loa Loa (eye worm) steroid hormone receptor 0.0107 0.045 0.1517
Schistosoma mansoni zinc finger protein 0.0015 0.0004 0.0024
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0022 0.0334
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0045 0.0153
Echinococcus multilocularis 0.0021 0.0033 0.0311
Trypanosoma brucei THT1 - hexose transporter, putative 0.002 0.0025 0.0409
Echinococcus multilocularis geminin 0.0169 0.0754 0.71
Brugia malayi hypothetical protein 0.0146 0.0642 0.2163
Giardia lamblia PHD finger protein 15 0.0028 0.0067 0.0345
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0197 0.0891 0.3002
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0459 0.8886
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Brugia malayi Common central domain of tyrosinase family protein 0.0091 0.0372 0.1252
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0115 0.0623
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0045 0.0212
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0178 0.3392
Loa Loa (eye worm) hypothetical protein 0.0024 0.0045 0.0153
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0107 0.045 0.2428
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0033 0.0033
Onchocerca volvulus Alhambra homolog 0.0028 0.0067 0.0622
Loa Loa (eye worm) hypothetical protein 0.0048 0.0166 0.0558
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0019 0.0021 0.0077
Brugia malayi nuclear hormone receptor 0.0107 0.045 0.1517
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Echinococcus multilocularis nuclear receptor nhr 48 0.005 0.0175 0.1651
Echinococcus granulosus intermediate filament protein 0.0027 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0029
Loa Loa (eye worm) hypothetical protein 0.0047 0.0158 0.0533
Onchocerca volvulus 0.002 0.0025 0.0234
Mycobacterium leprae Possible D-ribose-binding protein 0.0528 0.2507 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0175 0.0591
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Trichomonas vaginalis glucose transporter, putative 0.002 0.0025 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0045 0.0212
Schistosoma mansoni hypothetical protein 0.0038 0.0115 0.0623
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0459 0.2475
Loa Loa (eye worm) nuclear hormone receptor 0.005 0.0175 0.0591
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0045 0.0212
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0024 0.0048 0.02
Toxoplasma gondii transporter, major facilitator family protein 0.002 0.0025 0.0077
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0238 0.2238
Brugia malayi Bromodomain containing protein 0.0042 0.0134 0.045
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0372 0.1252
Brugia malayi hypothetical protein 0.0024 0.0049 0.0164
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0045 0.0153
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0146 0.0785
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0178 0.096
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0022 0.0022
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0459 0.3287
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.0625 0.442
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0081 0.0273
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0096 0.0906
Plasmodium falciparum hexose transporter 0.002 0.0025 0.0183
Loa Loa (eye worm) ShTK domain-containing protein 0.0091 0.0372 0.1252
Onchocerca volvulus 0.002 0.0025 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0107 0.045 0.1517
Schistosoma mansoni tar DNA-binding protein 0.0197 0.0891 0.4806
Loa Loa (eye worm) hypothetical protein 0.005 0.0175 0.0591
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0178 0.3392
Brugia malayi Uncoordinated protein 44 0.0014 0.000000010137 0.00000003416
Echinococcus multilocularis zinc finger protein 0.0023 0.0043 0.0401
Schistosoma mansoni tyrosinase precursor 0.0091 0.0372 0.2004
Brugia malayi hypothetical protein 0.0056 0.0205 0.069
Brugia malayi PHD-finger family protein 0.0028 0.0069 0.0231
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.004 0.0374
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.004 0.0124 0.234
Echinococcus granulosus GPCR family 2 0.0031 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0026 0.0056 0.0188
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0075 0.1087
Schistosoma mansoni RAR-like nuclear receptor 0.0107 0.045 0.2428
Plasmodium vivax hexose transporter 0.002 0.0025 0.0183
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.1352 1
Brugia malayi nuclear hormone receptor 0.005 0.0175 0.0591
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0025 0.0029
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0016 0.0037
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.012 0.0516 0.1989
Brugia malayi 6-phosphofructokinase 0.0108 0.0459 0.1546
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0178 0.3392
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0459 0.3287
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0022 0.0106
Onchocerca volvulus 0.002 0.0025 0.0234
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0061 0.0206
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0407 0.1373
Mycobacterium ulcerans two component sensor kinase MprB 0.0019 0.0021 0.0037
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0107 0.045 0.4236
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0146 0.0785
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0033 0.0337
Onchocerca volvulus 0.002 0.0025 0.0234
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0086
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.012 0.0516 0.3715
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0106 0.0356
Brugia malayi ShTK domain containing protein 0.0091 0.0372 0.1252
Loa Loa (eye worm) sugar transporter 0.002 0.0025 0.0086
Echinococcus granulosus zinc finger protein 0.0023 0.0043 0.0043
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.108 0.3638
Trichomonas vaginalis sugar transport protein, putative 0.002 0.0025 0.0029
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0116 0.0116
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0149 0.2577
Echinococcus multilocularis tar DNA binding protein 0.0197 0.0891 0.8386
Brugia malayi hypothetical protein 0.0021 0.0033 0.0111
Loa Loa (eye worm) hypothetical protein 0.0038 0.0117 0.0393
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0116 0.1091
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0178 0.3392
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0158 0.1489
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0073 0.0386
Trypanosoma brucei glucose transporter, putative 0.002 0.0025 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0107 0.045 0.1517
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0225 0.1216
Loa Loa (eye worm) hypothetical protein 0.005 0.0175 0.0591
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0081 0.0273
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0107 0.045 0.1517
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0225 0.152
Treponema pallidum methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-1) 0.0528 0.2507 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0033 0.0559
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0044 0.0552
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0086
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.002 0.0025 0.0108
Onchocerca volvulus 0.005 0.0175 0.1619
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0459 0.3287
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0107 0.045 0.2428
Schistosoma mansoni fatty acid binding protein 0.0205 0.0929 0.501
Trypanosoma brucei glucose transporter, putative 0.002 0.0025 0.0409
Loa Loa (eye worm) hypothetical protein 0.0056 0.0205 0.069
Brugia malayi hypothetical protein 0.005 0.0175 0.0591
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0073 0.0207
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.1352 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.1352 1
Brugia malayi major facilitator superfamily protein 0.002 0.0025 0.0086
Brugia malayi steroid hormone receptor 0.0107 0.045 0.1517
Onchocerca volvulus 0.0083 0.0334 0.3089
Onchocerca volvulus 0.0091 0.0372 0.3431
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.002 0.0025 0.0025
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0073 0.0386
Brugia malayi follicle stimulating hormone receptor 0.0236 0.108 0.3638
Onchocerca volvulus 0.002 0.0025 0.0234
Brugia malayi glucose-6-phosphate dehydrogenase 0.012 0.0516 0.1738
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0225 0.1216
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0019 0.0021 0.0037
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0019 0.0021 0.0077
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0075 0.0708
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0045 0.0179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0107 0.045 0.1517
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0022 0.0085
Plasmodium vivax SET domain protein, putative 0.003 0.0075 0.1182
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0107 0.045 0.4156
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.005 0.0175 0.0591
Giardia lamblia Hexose transporter 0.002 0.0025 0.0029
Plasmodium falciparum phd finger protein, putative 0.0028 0.0067 0.1024
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0056 0.0205 0.069
Loa Loa (eye worm) hypothetical protein 0.0021 0.0033 0.0111
Echinococcus granulosus fatty acid binding protein FABP2 0.0205 0.0929 0.0929
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0107 0.045 0.1517
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0149 0.0655 0.6164
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0073 0.1039
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.012 0.0516 0.4854
Onchocerca volvulus Putative transporter 0.002 0.0025 0.0234
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0045 0.0265
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Loa Loa (eye worm) hypothetical protein 0.005 0.0175 0.0591
Loa Loa (eye worm) hypothetical protein 0.005 0.0175 0.0591
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0019 0.0021 0.0037
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0107 0.045 0.1517
Onchocerca volvulus 0.0091 0.0372 0.3431
Brugia malayi hypothetical protein 0.0016 0.0007 0.0023
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0107 0.045 0.045
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.000000010137 0.000000095411
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Entamoeba histolytica hypothetical protein 0.0038 0.0115 0.0706
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0067 0.0364
Onchocerca volvulus 0.0091 0.0372 0.3431
Echinococcus multilocularis thyroid hormone receptor alpha 0.0232 0.1062 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0107 0.045 0.1517
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0086
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.012 0.0741
Schistosoma mansoni retinoic acid receptor RXR 0.0205 0.093 0.5015
Onchocerca volvulus 0.0066 0.0251 0.2316
Trypanosoma brucei glucose transporter, putative 0.002 0.0025 0.0409
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0105 0.0105
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.012 0.0516 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0081 0.0763
Toxoplasma gondii sugar transporter ST3 0.002 0.0025 0.0077
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.0625 0.2427
Echinococcus granulosus Sugar transporter ERD6 protein 0.002 0.0025 0.0025
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0022 0.0073
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0205 0.093 0.093
Mycobacterium ulcerans two component regulator - sensor kinase 0.0019 0.0021 0.0037
Echinococcus granulosus muscleblind protein 0.0149 0.0657 0.0657
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0178 0.1176
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0073 0.0386
Schistosoma mansoni hypothetical protein 0.0015 0.0004 0.0024
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0115 0.0115
Trichomonas vaginalis sugar transporter, putative 0.002 0.0025 0.0029
Trypanosoma brucei glucose transporter, putative 0.002 0.0025 0.0409
Leishmania major glucose transporter/membrane transporter D2, putative 0.002 0.0025 0.0409
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0086
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0372 0.1252
Schistosoma mansoni hypothetical protein 0.0169 0.0754 0.4069
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0 0.0001
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0334 0.3148
Schistosoma mansoni glucose transport protein 0.002 0.0025 0.0137
Brugia malayi Steroid receptor seven-up type 2 0.0107 0.045 0.1517
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0049 0.0652
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0251 0.4825
Loa Loa (eye worm) hypothetical protein 0.0044 0.0145 0.049
Loa Loa (eye worm) hypothetical protein 0.005 0.0175 0.0591
Brugia malayi intermediate filament protein 0.0027 0.0061 0.0206
Giardia lamblia Sugar-proton symporter 0.002 0.0025 0.0029
Brugia malayi PHD-finger family protein 0.0028 0.0067 0.0227
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0149 0.0957

Activities

Activity type Activity value Assay description Source Reference
Inflection point (functional) 0 Growth inhibition of human HCT116 cells after 72 hrs ChEMBL. 18042381
Inflection point (binding) = 620 nM Inhibition of HDAC1 (unknown origin) ChEMBL. 18042381
Inflection point (binding) = 620 nM Inhibition of HDAC1 (unknown origin) ChEMBL. 18042381

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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