Detailed information for compound 511708

Basic information

Technical information
  • TDR Targets ID: 511708
  • Name: 2-butyl-6-methyl-1-[[4-[2-(2H-tetrazol-5-yl)p henyl]phenyl]methyl]pyrazolo[3,4-b]pyridin-3- one
  • MW: 439.512 | Formula: C25H25N7O
  • H donors: 1 H acceptors: 5 LogP: 4.72 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCn1c(=O)c2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)nc(cc2)C
  • InChi: 1S/C25H25N7O/c1-3-4-15-31-25(33)22-14-9-17(2)26-24(22)32(31)16-18-10-12-19(13-11-18)20-7-5-6-8-21(20)23-27-29-30-28-23/h5-14H,3-4,15-16H2,1-2H3,(H,27,28,29,30)
  • InChiKey: GCRHVXYVQWLSJN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-butyl-6-methyl-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-3-pyrazolo[3,4-b]pyridinone
  • 2-butyl-6-methyl-1-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]pyrazolo[3,4-b]pyridin-3-one
  • 2-butyl-6-methyl-1-[4-[2-(2H-tetrazol-5-yl)phenyl]benzyl]pyrazolo[3,4-b]pyridin-3-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Type-1A angiotensin II receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Type-1A angiotensin II receptor   359 aa 336 aa 22.3 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Type-1A angiotensin II receptor   359 aa 346 aa 18.2 %
Loa Loa (eye worm) hypothetical protein Type-1A angiotensin II receptor   359 aa 330 aa 26.7 %
Echinococcus multilocularis neuropeptide receptor Type-1A angiotensin II receptor   359 aa 316 aa 25.3 %
Schistosoma mansoni peptide (allatostatin)-like receptor Type-1A angiotensin II receptor   359 aa 314 aa 26.1 %
Echinococcus multilocularis G-protein coupled receptor, putative Type-1A angiotensin II receptor   359 aa 308 aa 22.4 %
Echinococcus granulosus growth hormone secretagogue receptor type 1 Type-1A angiotensin II receptor   359 aa 351 aa 21.9 %
Brugia malayi putative neuropeptide receptor NPR1 Type-1A angiotensin II receptor   359 aa 295 aa 27.5 %
Echinococcus granulosus thyrotropin releasing hormone receptor Type-1A angiotensin II receptor   359 aa 337 aa 24.0 %
Onchocerca volvulus E3 ubiquitin-protein ligase rpm-1 homolog Type-1A angiotensin II receptor   359 aa 352 aa 20.5 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor Type-1A angiotensin II receptor   359 aa 407 aa 19.4 %
Onchocerca volvulus Type-1A angiotensin II receptor   359 aa 303 aa 25.1 %
Echinococcus granulosus allatostatin A receptor Type-1A angiotensin II receptor   359 aa 348 aa 25.9 %
Loa Loa (eye worm) hypothetical protein Type-1A angiotensin II receptor   359 aa 335 aa 23.3 %
Onchocerca volvulus Type-1A angiotensin II receptor   359 aa 386 aa 24.9 %
Loa Loa (eye worm) neuropeptide F receptor Type-1A angiotensin II receptor   359 aa 356 aa 24.2 %
Echinococcus multilocularis growth hormone secretagogue receptor type 1 Type-1A angiotensin II receptor   359 aa 351 aa 21.9 %
Brugia malayi GnHR receptor homolog Type-1A angiotensin II receptor   359 aa 364 aa 20.9 %
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor Type-1A angiotensin II receptor   359 aa 406 aa 20.0 %
Onchocerca volvulus Type-1A angiotensin II receptor   359 aa 294 aa 23.8 %
Echinococcus granulosus tm gpcr rhodopsin Type-1A angiotensin II receptor   359 aa 303 aa 22.4 %
Schistosoma japonicum Rhodopsin, putative Type-1A angiotensin II receptor   359 aa 327 aa 24.2 %
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Type-1A angiotensin II receptor   359 aa 303 aa 22.4 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Type-1A angiotensin II receptor   359 aa 311 aa 23.5 %
Schistosoma mansoni opsin-like receptor Type-1A angiotensin II receptor   359 aa 299 aa 25.1 %
Echinococcus granulosus neuropeptide receptor Type-1A angiotensin II receptor   359 aa 316 aa 25.0 %
Onchocerca volvulus Type-1A angiotensin II receptor   359 aa 312 aa 19.2 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Type-1A angiotensin II receptor   359 aa 334 aa 23.7 %
Onchocerca volvulus Type-1A angiotensin II receptor   359 aa 314 aa 25.8 %
Onchocerca volvulus Type-1A angiotensin II receptor   359 aa 395 aa 23.0 %
Echinococcus multilocularis allatostatin A receptor Type-1A angiotensin II receptor   359 aa 348 aa 25.9 %
Brugia malayi ORL1-like opioid receptor Type-1A angiotensin II receptor   359 aa 314 aa 20.1 %
Schistosoma mansoni adenoreceptor Type-1A angiotensin II receptor   359 aa 329 aa 24.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus GPCR family 2 0.0034 0.0155 0.0219
Loa Loa (eye worm) hypothetical protein 0.0108 0.0582 0.0841
Trichomonas vaginalis set domain proteins, putative 0.0282 0.1584 0.1584
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.0088 0.0122
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0088 0.0088
Schistosoma mansoni ferritin light chain 0.001 0.0013 0.0009
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0088 0.0122
Schistosoma mansoni opsin-like receptor 0.0204 0.1137 0.1188
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0158 0.0513
Plasmodium falciparum carbonic anhydrase 0.0527 0.3003 1
Onchocerca volvulus 0.0033 0.0147 0.0901
Schistosoma mansoni amine GPCR 0.0204 0.1137 0.1188
Brugia malayi Thioredoxin reductase 0.0056 0.0281 0.0403
Leishmania major ATP-dependent phosphofructokinase 0.0129 0.0702 0.0731
Loa Loa (eye worm) hypothetical protein 0.0034 0.0155 0.0219
Entamoeba histolytica phosphofructokinase, putative 0.0129 0.0702 0.0731
Echinococcus granulosus 7TM GPCR rhodopsin 0.0204 0.1137 0.1649
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0069 0.0095
Brugia malayi hypothetical protein 0.001 0.0016 0.0017
Brugia malayi G-protein coupled receptor 0.0204 0.1137 0.1649
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0175 0.0179
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0069 0.0095
Trichomonas vaginalis phosphofructokinase, putative 0.0129 0.0702 0.0702
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0046 0.0061
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0007 0.0003
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1659 0.954 1
Leishmania major carbonic anhydrase family protein, putative 0.1659 0.954 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0017 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.0204 0.1137 0.1649
Echinococcus multilocularis G-protein coupled receptor, putative 0.0204 0.1137 0.1649
Loa Loa (eye worm) hypothetical protein 0.0527 0.3003 0.4367
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0204 0.1137 0.1649
Brugia malayi beta-lactamase family protein 0.0035 0.0159 0.0225
Mycobacterium ulcerans arylsulfatase, AslA 0.001 0.0016 0.0003
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0069 0.0056
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0204 0.1137 0.1649
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0193 0.0193
Schistosoma mansoni hypothetical protein 0.0034 0.0155 0.0158
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0013 0.003 0.0038
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0038 0.005
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0204 0.1137 0.1649
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0012 0.0011
Toxoplasma gondii hypothetical protein 0.0527 0.3003 1
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Echinococcus multilocularis neuropeptide Y receptor 0.0204 0.1137 0.1649
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0166 0.0235
Echinococcus multilocularis orexin receptor type 2 0.0204 0.1137 0.1649
Echinococcus granulosus lamin dm0 0.0032 0.0142 0.02
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0023 0.0027
Echinococcus granulosus sex peptide receptor 0.0204 0.1137 0.1649
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0204 0.1137 0.1188
Treponema pallidum bacterioferrin (TpF1) 0.001 0.0013 0.0124
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0022 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0088 0.0088
Echinococcus multilocularis g protein coupled receptor 0.0204 0.1137 0.1649
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.001 0.0013 0.0013
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0158 0.0158
Echinococcus granulosus somatostatin receptor 0.0204 0.1137 0.1649
Trypanosoma brucei carbonic anhydrase-like protein 0.1197 0.6872 1
Loa Loa (eye worm) neuropeptide F receptor 0.0204 0.1137 0.1649
Echinococcus multilocularis expressed protein 0.001 0.0013 0.0013
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0204 0.1137 0.1188
Echinococcus granulosus g-protein coupled receptor 0.0204 0.1137 0.1649
Echinococcus granulosus smad 0.0009 0.001 0.0008
Echinococcus granulosus g protein coupled receptor 0.0204 0.1137 0.1649
Schistosoma mansoni opsin-like receptor 0.0204 0.1137 0.1188
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Schistosoma mansoni biogenic amine receptor 0.0204 0.1137 0.1188
Brugia malayi Smad1 0.0009 0.001 0.0008
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0017 0.0043
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Onchocerca volvulus 0.0204 0.1137 0.7169
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0191 0.2683
Schistosoma mansoni hypothetical protein 0.0074 0.0384 0.0399
Loa Loa (eye worm) hypothetical protein 0.0223 0.1247 0.1809
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Schistosoma mansoni apoferritin-2 0.001 0.0013 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.1517 0.1517
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0069 0.0068
Echinococcus multilocularis neuropeptides capa receptor 0.0204 0.1137 0.1649
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0527 0.3003 0.4367
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0175 0.0179
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0069 0.0068
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Schistosoma mansoni ap endonuclease 0.0041 0.0191 0.0196
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0159 0.0225
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0248 0.1387 0.2014
Mycobacterium tuberculosis Probable reductase 0.0128 0.0696 0.1045
Trypanosoma brucei glucosidase, putative 0.0038 0.0175 0.0249
Brugia malayi MH1 domain containing protein 0.0009 0.001 0.0008
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0159 0.0234
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0128 0.0696 0.0717
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0009 0.0007 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0069 0.0095
Loa Loa (eye worm) beta-lactamase 0.0035 0.0159 0.0225
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0088 0.0088
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0044 0.021 0.0299
Echinococcus multilocularis fmrfamide receptor 0.0204 0.1137 0.1649
Echinococcus granulosus expressed protein 0.0443 0.2515 0.3655
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0122
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0007 0.0003
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0038 0.0036
Echinococcus multilocularis somatostatin receptor 0.0204 0.1137 0.1649
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0233 0.024
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1197 0.6872 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0056
Leishmania major C-8 sterol isomerase-like protein 0.0437 0.248 0.2596
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0527 0.3003 0.4367
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0004 0.0004
Loa Loa (eye worm) thioredoxin reductase 0.0056 0.0281 0.0403
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Echinococcus granulosus rhodopsin orphan GPCR 0.0204 0.1137 0.1649
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0154 0.0218
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.021 0.0299
Brugia malayi 6-phosphofructokinase 0.0129 0.0702 0.1016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0159 0.0162
Schistosoma mansoni hypothetical protein 0.0034 0.0155 0.0158
Schistosoma mansoni hypothetical protein 0.0034 0.0155 0.0158
Mycobacterium tuberculosis Conserved protein 0.0035 0.0159 0.0234
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0159 0.0225
Echinococcus granulosus carbonic anhydrase 0.0527 0.3003 0.4367
Onchocerca volvulus 0.0204 0.1137 0.7169
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0007 0.0003
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0175 0.0175
Brugia malayi MH2 domain containing protein 0.0009 0.001 0.0008
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0204 0.1137 0.1649
Schistosoma mansoni smad1 5 8 and 0.0009 0.001 0.0006
Mycobacterium tuberculosis Conserved protein 0.0035 0.0159 0.0234
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Echinococcus multilocularis rhodopsin orphan GPCR 0.0204 0.1137 0.1649
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0088 0.0122
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.0088 0.0122
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0204 0.1137 0.1649
Echinococcus granulosus expressed protein 0.001 0.0013 0.0013
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0017 0.0696
Schistosoma mansoni alpha glucosidase 0.0038 0.0175 0.0179
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0072 0.0071
Plasmodium falciparum thioredoxin reductase 0.0019 0.0069 0.0217
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0017
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0204 0.1137 0.1649
Onchocerca volvulus 0.0204 0.1137 0.7169
Onchocerca volvulus 0.0204 0.1137 0.7169
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Brugia malayi MH1 domain containing protein 0.0009 0.001 0.0008
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0088 0.0122
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0009 0.0007 0.0004
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0384 0.0553
Schistosoma mansoni adenoreceptor 0.0204 0.1137 0.1188
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0017 0.0019
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0235
Schistosoma mansoni histamine h1 receptor 0.0204 0.1137 0.1188
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0191 0.0272
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0159 0.0234
Echinococcus granulosus voltage gated potassium channel 0.0013 0.003 0.0038
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0122
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0088 0.0122
Loa Loa (eye worm) G-protein coupled receptor 0.0204 0.1137 0.1649
Mycobacterium tuberculosis Bacterioferritin BfrB 0.001 0.0013 0.0013
Brugia malayi Melatonin receptor type 1A 0.0204 0.1137 0.1649
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0204 0.1137 0.1188
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0204 0.1137 0.1188
Loa Loa (eye worm) glutathione reductase 0.0056 0.0281 0.0403
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0122
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0069 0.0095
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Trichomonas vaginalis esterase, putative 0.0035 0.0159 0.0159
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0158 0.0513
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Echinococcus granulosus intermediate filament protein 0.0032 0.0142 0.02
Echinococcus multilocularis rhodopsin orphan GPCR 0.0204 0.1137 0.1649
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0159 0.0234
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0044 0.021 0.0299
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0069 0.0068
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.001 0.0008
Echinococcus multilocularis neuropeptide FF receptor 2 0.0204 0.1137 0.1649
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0142 0.02
Echinococcus granulosus neuropeptide Y receptor 0.0204 0.1137 0.1649
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0069 0.0217
Schistosoma mansoni neuropeptide receptor 0.0204 0.1137 0.1188
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0204 0.1137 0.1649
Schistosoma mansoni neuropeptide F-like receptor 0.0204 0.1137 0.1188
Plasmodium falciparum thioredoxin reductase 0.0056 0.0281 0.0922
Schistosoma mansoni neuropeptide f receptor 76f 0.0204 0.1137 0.1188
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0009 0.0007 0.0004
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0204 0.1137 0.1188
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0023 0.0027
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.001 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.1738 1 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0191 0.0196
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0103 0.0103
Echinococcus granulosus alpha 1A adrenergic receptor 0.0204 0.1137 0.1649
Mycobacterium ulcerans sulfatase 0.001 0.0016 0.0003
Echinococcus granulosus neuropeptide receptor A26 0.0204 0.1137 0.1649
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.1517 0.1517
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0129 0.0702 0.0723
Brugia malayi GnHR receptor homolog 0.0204 0.1137 0.1649
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0038 0.0036
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Echinococcus granulosus neuropeptide receptor 0.0204 0.1137 0.1649
Echinococcus granulosus Smad4 0.0009 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0204 0.1137 0.1188
Loa Loa (eye worm) TYRA-2 protein 0.0204 0.1137 0.1649
Echinococcus multilocularis GPCR, family 2 0.0034 0.0155 0.0219
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0038 0.0038
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0204 0.1137 0.1649
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0437 0.248 0.3605
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.021 0.0299
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0069 0.0056
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0159 0.0146
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0204 0.1137 0.1649
Brugia malayi hypothetical protein 0.0144 0.0791 0.1146
Brugia malayi glutathione reductase 0.0056 0.0281 0.0403
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0159 0.0225
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0158 0.0513
Onchocerca volvulus 0.0204 0.1137 0.7169
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0032 0.0142 0.02
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0981 0.0981
Brugia malayi hypothetical protein 0.0204 0.1137 0.1649
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0191 0.0191
Echinococcus multilocularis rhodopsin orphan GPCR 0.0204 0.1137 0.1649
Loa Loa (eye worm) neuropeptide F receptor 0.0204 0.1137 0.1649
Trichomonas vaginalis phosphofructokinase, putative 0.0129 0.0702 0.0702
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0159 0.0162
Echinococcus multilocularis neuropeptide s receptor 0.0204 0.1137 0.1649
Schistosoma mansoni neuropeptide F-like receptor 0.0204 0.1137 0.1188
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0191 0.0272
Brugia malayi RE15519p 0.0204 0.1137 0.1649
Loa Loa (eye worm) hypothetical protein 0.0636 0.3633 0.5284
Brugia malayi Pre-SET motif family protein 0.0248 0.1387 0.2014
Brugia malayi follicle stimulating hormone receptor 0.0477 0.2713 0.3944
Onchocerca volvulus 0.0204 0.1137 0.7169
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0166 0.0169
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0155 0.0219
Mycobacterium ulcerans beta-lactamase 0.0035 0.0159 0.0146
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0159 0.0234
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0367 0.038
Brugia malayi hypothetical protein 0.0204 0.1137 0.1649
Echinococcus granulosus rhodopsin orphan GPCR 0.0204 0.1137 0.1649
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.0088 0.0088
Schistosoma mansoni opsin-like receptor 0.0204 0.1137 0.1188
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0069 0.0069
Mycobacterium tuberculosis Conserved protein 0.0035 0.0159 0.0234
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Onchocerca volvulus 0.0204 0.1137 0.7169
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0175 0.0179
Loa Loa (eye worm) hypothetical protein 0.0636 0.3633 0.5284
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Treponema pallidum NADH oxidase 0.0019 0.0069 0.0931
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0008 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0056 0.1862
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.001 0.0016 0.0017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0204 0.1137 0.1649
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0175 0.0249
Echinococcus multilocularis carbonic anhydrase 0.0527 0.3003 0.4367
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.027 0.1517 0.2203
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0129 0.0702 0.1016
Trypanosoma brucei C-8 sterol isomerase, putative 0.0437 0.248 0.3605
Schistosoma mansoni carbonic anhydrase-related 0.0527 0.3003 0.3145
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0981 0.0981
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.001 0.0016 0.0016
Schistosoma mansoni ferritin 0.001 0.0013 0.0009
Onchocerca volvulus 0.0204 0.1137 0.7169
Loa Loa (eye worm) hypothetical protein 0.0035 0.0159 0.0225
Echinococcus granulosus rhodopsin orphan GPCR 0.0204 0.1137 0.1649
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0159 0.0225
Echinococcus multilocularis neuropeptide Y receptor 0.0204 0.1137 0.1649
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Brugia malayi beta-lactamase family protein 0.0035 0.0159 0.0225
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0088 0.0088
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0981 0.0981
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0069 0.0095
Echinococcus multilocularis rhodopsin orphan GPCR 0.0204 0.1137 0.1649
Brugia malayi Dopamine receptor 0.0204 0.1137 0.1649
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0069 0.0217
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0191 0.0283
Echinococcus multilocularis serotonin receptor 0.0636 0.3633 0.5284
Brugia malayi MH2 domain containing protein 0.0009 0.001 0.0008
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0191 0.0272
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0166 0.0169
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0204 0.1137 0.1188
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Schistosoma mansoni 6-phosphofructokinase 0.0129 0.0702 0.0731
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0204 0.1137 0.1649
Loa Loa (eye worm) hypothetical protein 0.0376 0.2131 0.3096
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0204 0.1137 0.1649
Echinococcus multilocularis smad 0.0009 0.001 0.0008
Echinococcus granulosus biogenic amine 5HT receptor 0.0204 0.1137 0.1649
Brugia malayi MH2 domain containing protein 0.0134 0.0733 0.1061
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0069 0.347
Echinococcus granulosus g protein coupled receptor 0.0204 0.1137 0.1649
Echinococcus granulosus neuropeptides capa receptor 0.0204 0.1137 0.1649
Echinococcus granulosus bloom syndrome protein 0.0025 0.0103 0.0144
Brugia malayi hypothetical protein 0.0204 0.1137 0.1649
Echinococcus granulosus carbonic anhydrase 0.0527 0.3003 0.4367
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0088 0.0122
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0142 0.0779 0.117
Onchocerca volvulus 0.0204 0.1137 0.7169
Plasmodium vivax glutathione reductase, putative 0.0056 0.0281 1
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.0733 0.1061
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0088 0.0122
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0038 0.0038
Schistosoma mansoni cpg binding protein 0.0035 0.0158 0.0161
Schistosoma mansoni microtubule-associated protein tau 0.0818 0.4685 0.4909
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0046 0.0061
Echinococcus granulosus fmrfamide receptor 0.0204 0.1137 0.1649
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0324 0.1066
Schistosoma mansoni amine GPCR 0.0204 0.1137 0.1188
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.001 0.0016 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0981 0.0981
Brugia malayi G-protein coupled receptor 0.0204 0.1137 0.1649
Entamoeba histolytica carbonic anhydrase, putative 0.1659 0.954 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0004
Onchocerca volvulus Neuropeptide F receptor homolog 0.0204 0.1137 0.7169
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0129 0.0702 0.1016
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1197 0.6872 0.7202
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0159 0.0225
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0158 0.0158
Mycobacterium ulcerans arylsulfatase AtsB 0.001 0.0016 0.0003
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0088 0.0122
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0158 0.0513
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Echinococcus granulosus rhodopsin orphan GPCR 0.0204 0.1137 0.1649
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0204 0.1137 0.1188
Onchocerca volvulus 0.0204 0.1137 0.7169
Schistosoma mansoni cpg binding protein 0.0033 0.0147 0.0149
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0158 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0009 0.0007 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0204 0.1137 0.1649
Loa Loa (eye worm) hypothetical protein 0.0074 0.0384 0.0553
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.0088 0.0122
Echinococcus granulosus neuropeptide FF receptor 2 0.0204 0.1137 0.1649
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0088 0.0122
Schistosoma mansoni myosin xvIII 0.0204 0.1137 0.1188
Schistosoma mansoni amine GPCR 0.0204 0.1137 0.1188
Trypanosoma cruzi trypanothione reductase, putative 0.0056 0.0281 0.0403
Echinococcus granulosus g protein coupled receptor 0.0204 0.1137 0.1649
Loa Loa (eye worm) melatonin receptor type 1A 0.0204 0.1137 0.1649
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0175 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Schistosoma mansoni growth hormone secretagogue receptor 0.0204 0.1137 0.1188
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0122
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0204 0.1137 0.1649
Brugia malayi Cytochrome P450 family protein 0.0027 0.0112 0.0157
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0038 0.0038
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0007 0.0003
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0069 0.0098
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0204 0.1137 0.1649
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0582 0.0841
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0204 0.1137 0.1188
Echinococcus multilocularis ferritin 0.001 0.0013 0.0013
Brugia malayi Serotonin receptor 0.0204 0.1137 0.1649
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0017 0.0019
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0008 0.0004 0.0004
Echinococcus granulosus cpg binding protein 0.0035 0.0158 0.0223
Schistosoma mansoni Smad4 0.0009 0.001 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0088 0.0088
Echinococcus granulosus G protein coupled receptor 139 0.0204 0.1137 0.1649
Brugia malayi hypothetical protein 0.0204 0.1137 0.1649
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1197 0.6872 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0204 0.1137 0.1649
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0155 0.0219
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0582 0.0841
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.0088 0.0122
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0981 0.0981
Trichomonas vaginalis phosphofructokinase, putative 0.0129 0.0702 0.0702
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0191 0.0272
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0191 1
Schistosoma mansoni neuropeptide receptor 0.0204 0.1137 0.1188
Schistosoma mansoni DNA helicase recq5 0.001 0.0017 0.0014
Brugia malayi Dopamine receptor protein 2 0.0204 0.1137 0.1649
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0069 0.0056
Brugia malayi hypothetical protein 0.0204 0.1137 0.1649
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0204 0.1137 0.1188
Plasmodium falciparum glutathione reductase 0.0056 0.0281 0.0922
Echinococcus granulosus thioredoxin glutathione reductase 0.0056 0.0281 0.0403
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0204 0.1137 0.1649
Trichomonas vaginalis Phospholipase C precursor, putative 0.0008 0.0004 0.0004
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.003 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0204 0.1137 0.1188
Schistosoma mansoni ap endonuclease 0.0041 0.0191 0.0196
Schistosoma mansoni carbonic anhydrase-related 0.0527 0.3003 0.3145
Mycobacterium tuberculosis Possible hydrolase 0.001 0.0016 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0204 0.1137 0.1649
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0204 0.1137 0.1649
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0158 0.0158
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0012 0.0011
Echinococcus granulosus neuropeptide Y receptor 0.0204 0.1137 0.1649
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0088 0.0122
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0088 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0204 0.1137 0.1188
Onchocerca volvulus 0.0282 0.1584 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0175 0.0175
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0193 0.0193
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0159 0.0146
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0088 0.0122
Echinococcus multilocularis lamin 0.0032 0.0142 0.02
Schistosoma mansoni alpha-glucosidase 0.0147 0.0804 0.0839
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0175 0.0249
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0204 0.1137 0.1649
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0129 0.0702 0.1054
Brugia malayi PXA domain containing protein 0.0023 0.0088 0.0122
Brugia malayi 6-phosphofructokinase 0.0129 0.0702 0.1016
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0159 0.0234
Schistosoma mansoni ferritin 0.001 0.0013 0.0009
Schistosoma mansoni ferritin light chain 0.001 0.0013 0.0009
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0069 0.0095
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.0941 0.1364
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0159 0.0225
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0035 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Toxoplasma gondii ABC1 family protein 0.0035 0.0159 0.0516
Echinococcus multilocularis carbonic anhydrase 0.0527 0.3003 0.4367
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.001 0.0008
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0009 0.0007 0.0004
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0175 0.0175
Mycobacterium ulcerans hypothetical protein 0.0035 0.0159 0.0146
Mycobacterium tuberculosis Probable sulfatase 0.001 0.0016 0.0017
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.001 0.0016 0.0016
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0007 0.0004
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0085 0.027
Brugia malayi hypothetical protein 0.0204 0.1137 0.1649
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0175 0.0175
Schistosoma mansoni biogenic amine receptor 0.0204 0.1137 0.1188
Plasmodium vivax SET domain protein, putative 0.0036 0.0166 0.5832
Giardia lamblia Hypothetical protein 0.001 0.0016 0.0613
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0038 0.005
Loa Loa (eye worm) 6-phosphofructokinase 0.0129 0.0702 0.1016
Mycobacterium ulcerans lipase LipD 0.0035 0.0159 0.0146
Brugia malayi hypothetical protein 0.0204 0.1137 0.1649
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0056 0.0075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0204 0.1137 0.1188
Onchocerca volvulus 0.0032 0.0142 0.087
Loa Loa (eye worm) G-protein coupled receptor 0.0204 0.1137 0.1649
Schistosoma mansoni alpha-glucosidase 0.0147 0.0804 0.0839
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0088 0.0088
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0158 0.0158
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0088 0.0088
Echinococcus granulosus neuropeptides capa receptor 0.0204 0.1137 0.1649
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0007 0.0004
Brugia malayi ORL1-like opioid receptor 0.0204 0.1137 0.1649
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0017 0.0019
Brugia malayi putative neuropeptide receptor NPR1 0.0204 0.1137 0.1649
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Onchocerca volvulus 0.0204 0.1137 0.7169
Loa Loa (eye worm) hypothetical protein 0.0035 0.0159 0.0225
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0159 0.0153
Schistosoma mansoni intermediate filament proteins 0.0032 0.0142 0.0144
Schistosoma mansoni smad 0.0009 0.001 0.0006
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0046 0.0061
Brugia malayi hypothetical protein 0.0023 0.0088 0.0122
Entamoeba histolytica hypothetical protein 0.0023 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0038 0.0176 0.025
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0204 0.1137 0.1649
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0233 0.024
Brugia malayi intermediate filament protein 0.0032 0.0142 0.02
Trichomonas vaginalis conserved hypothetical protein 0.1738 1 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0191 1
Echinococcus granulosus allatostatin A receptor 0.0204 0.1137 0.1649
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0175 0.0249
Brugia malayi Dopamine receptor protein 1 0.0204 0.1137 0.1649
Echinococcus multilocularis thioredoxin glutathione reductase 0.0056 0.0281 0.0403
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0007 0.0004
Echinococcus granulosus carbonic anhydrase 0.0527 0.3003 0.4367
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0155 0.0219
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0088 0.0088
Onchocerca volvulus 0.0204 0.1137 0.7169
Echinococcus granulosus tm gpcr rhodopsin 0.0204 0.1137 0.1649
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1036 0.1036
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0159 0.0234
Plasmodium vivax thioredoxin reductase, putative 0.0056 0.0281 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0175 0.0249
Echinococcus multilocularis neuropeptide receptor A26 0.0204 0.1137 0.1649
Mycobacterium ulcerans arylsulfatase AtsD 0.001 0.0016 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0038 0.0038
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0155 0.0219
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Trichomonas vaginalis phosphofructokinase, putative 0.0129 0.0702 0.0702
Schistosoma mansoni hypothetical protein 0.0468 0.2659 0.2784
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0088 0.0088
Schistosoma mansoni 6-phosphofructokinase 0.0129 0.0702 0.0731
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0204 0.1137 0.1188
Trypanosoma brucei trypanothione reductase 0.0056 0.0281 0.0403
Echinococcus multilocularis neuropeptide receptor 0.0204 0.1137 0.1649
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Onchocerca volvulus 0.0032 0.0142 0.087
Echinococcus granulosus biogenic amine 5HT receptor 0.0636 0.3633 0.5284
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Schistosoma mansoni ferritin 0.001 0.0013 0.0009
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.0733 0.1061
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0103 0.0144
Loa Loa (eye worm) Smad1 0.0009 0.001 0.0008
Entamoeba histolytica phosphofructokinase, putative 0.0129 0.0702 0.0731
Schistosoma mansoni biogenic amine (5HT) receptor 0.0204 0.1137 0.1188
Echinococcus granulosus tm gpcr rhodopsin 0.0204 0.1137 0.1649
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0204 0.1137 0.1649
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0204 0.1137 0.1649
Schistosoma mansoni hypothetical protein 0.0204 0.1137 0.1188
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.0088 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0069 0.2347
Schistosoma mansoni neuropeptide receptor 0.0204 0.1137 0.1188
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0582 0.0841
Brugia malayi Glycosyl hydrolases family 31 protein 0.017 0.0941 0.1364
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0158 0.5562
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0204 0.1137 0.1649
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0069 0.2347
Loa Loa (eye worm) 6-phosphofructokinase 0.0129 0.0702 0.1016
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0155 0.0219
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0069 0.0095
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0122
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0008 0.0004 0.0004
Onchocerca volvulus 0.0204 0.1137 0.7169
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0038 0.005
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0142 0.02
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0204 0.1137 0.1188
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.001 0.0006
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.001 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.1517 0.1517
Leishmania major trypanothione reductase 0.0056 0.0281 0.029
Schistosoma mansoni hypothetical protein 0.0204 0.1137 0.1188
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0069 0.0095
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0128 0.0696 0.1045
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Trichomonas vaginalis ferritin, putative 0.001 0.0013 0.0013
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0017 0.0043
Echinococcus granulosus neuropeptide s receptor 0.0204 0.1137 0.1649
Mycobacterium ulcerans 6-phosphofructokinase 0.0129 0.0702 0.069
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0007 0.0003
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0204 0.1137 0.1649
Schistosoma mansoni amine GPCR 0.0204 0.1137 0.1188
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0088 0.0122
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0088 0.0122
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.0158 0.2206
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0204 0.1137 0.1188
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.0088 0.0122
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0158 0.0513
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0007 0.0004
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0191 0.0624
Echinococcus multilocularis g protein coupled receptor 0.0204 0.1137 0.1649
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0191 0.0196
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0038 0.0038
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0191 0.0191
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0008 0.0004 0.0004
Echinococcus multilocularis neuropeptides capa receptor 0.0204 0.1137 0.1649
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Echinococcus granulosus neuropeptide receptor 0.0204 0.1137 0.1649
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0038 0.0215
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0056
Echinococcus multilocularis carbonic anhydrase 0.0527 0.3003 0.4367
Loa Loa (eye worm) hypothetical protein 0.0527 0.3003 0.4367
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0158 0.0158
Schistosoma mansoni amine GPCR 0.0204 0.1137 0.1188
Schistosoma mansoni neuropeptide receptor 0.0204 0.1137 0.1188
Onchocerca volvulus 0.0204 0.1137 0.7169
Echinococcus multilocularis dnaJ subfamily B 0.0468 0.2659 0.3865
Echinococcus granulosus serotonin receptor 0.0204 0.1137 0.1649
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0035 0.0045
Loa Loa (eye worm) hypothetical protein 0.0035 0.0159 0.0225
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0023 0.0027
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0009 0.0007 0.0004
Onchocerca volvulus 0.0035 0.0159 0.098
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0142 0.0779 0.117
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0204 0.1137 0.1649
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0527 0.3003 0.4367
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0527 0.3003 0.4367
Toxoplasma gondii thioredoxin reductase 0.0056 0.0281 0.0922
Onchocerca volvulus 0.0204 0.1137 0.7169
Schistosoma mansoni carbonic anhydrase 0.0527 0.3003 0.3145
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.1517 0.1517
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Loa Loa (eye worm) carbonic anhydrase 3 0.1197 0.6872 1
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0069 0.0217
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0204 0.1137 0.1649
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0527 0.3003 0.4367
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Schistosoma mansoni apoferritin-2 0.001 0.0013 0.0009
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.0088 0.0122
Brugia malayi AKH receptor 0.0204 0.1137 0.1649
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0088 0.0122
Schistosoma mansoni hypothetical protein 0.0204 0.1137 0.1188
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0055 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0088 0.0088
Mycobacterium ulcerans arylsulfatase AtsD 0.001 0.0016 0.0003
Brugia malayi neuropeptide F receptor 0.0204 0.1137 0.1649
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0191 0.0272
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0069 0.0095
Mycobacterium tuberculosis Probable oxidoreductase 0.0142 0.0779 0.117
Onchocerca volvulus 0.0099 0.0526 0.3304
Echinococcus granulosus lysosomal alpha glucosidase 0.017 0.0941 0.1364
Echinococcus multilocularis lamin dm0 0.0032 0.0142 0.02
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.1517 0.1517
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0159 0.0225
Brugia malayi CXXC zinc finger family protein 0.0033 0.0147 0.0207
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0159 0.0159
Brugia malayi G protein-coupled receptor F59B2.13 0.0204 0.1137 0.1649
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0069 0.0095
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0142 0.02
Schistosoma mansoni cpg binding protein 0.0035 0.0158 0.0161
Brugia malayi G protein-coupled receptor 0.0204 0.1137 0.1649
Schistosoma mansoni biogenic amine receptor 0.0204 0.1137 0.1188
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.0088 0.0122
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0166 0.0538
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.001 0.0016 0.0073
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0204 0.1137 0.1649
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0056 0.0281 0.0418
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1197 0.6872 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0204 0.1137 0.1649
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0112 0.0157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0204 0.1137 0.1188
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0204 0.1137 0.1188
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0191 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0088 0.0088
Echinococcus multilocularis g-protein coupled receptor 0.0204 0.1137 0.1649
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1197 0.6872 1
Onchocerca volvulus 0.0036 0.0166 0.1021
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0009 0.0007 0.0004
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0069 0.3153
Leishmania major hypothetical protein, conserved 0.0035 0.0159 0.0162
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0129 0.0702 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.005
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.0158 0.0158
Echinococcus granulosus 7tm_1 domain containing protein 0.0204 0.1137 0.1649
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0191 0.0272
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0008 0.0004 0.0004
Brugia malayi putative neuropeptide receptor 0.0204 0.1137 0.1649
Schistosoma mansoni smad1 5 8 and 0.0009 0.001 0.0006
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0175 0.0175
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0142 0.0779 0.0803
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0069 0.0095
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0159 0.5597
Brugia malayi hypothetical protein 0.0204 0.1137 0.1649
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0069 0.0095
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0159 0.0234
Loa Loa (eye worm) hypothetical protein 0.0035 0.0159 0.0225
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1036 0.1036
Schistosoma mansoni hypothetical protein 0.0527 0.3003 0.3145
Schistosoma mansoni DNA helicase recq1 0.001 0.0017 0.0014
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0175 0.0175
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0175 0.0175
Schistosoma mansoni hypothetical protein 0.0034 0.0155 0.0158
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0069 0.0068
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0088 0.0122
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0017
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0175 0.0175
Mycobacterium ulcerans carbonic anhydrase 0.1659 0.954 0.954
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.0941 0.1364
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0585 0.3334 0.5032
Echinococcus granulosus rhodopsin orphan GPCR 0.0204 0.1137 0.1649
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Echinococcus multilocularis carbonic anhydrase II 0.1197 0.6872 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0962 0.5513 0.8021
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0155 0.0219
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0981 0.0981
Echinococcus multilocularis expressed protein 0.0443 0.2515 0.3655
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0159 0.0159
Schistosoma mansoni carbonic anhydrase-related 0.0527 0.3003 0.3145
Entamoeba histolytica hypothetical protein 0.0023 0.0088 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0069 0.0095
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.017 0.0941 0.1364
Loa Loa (eye worm) phosphofructokinase 0.0129 0.0702 0.1016
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0204 0.1137 0.1188
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.1249 0.188
Echinococcus multilocularis microtubule associated protein 2 0.0818 0.4685 0.6816
Loa Loa (eye worm) hypothetical protein 0.0035 0.0159 0.0225
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0069 0.0069
Brugia malayi Tachykinin-like peptides receptor 99D 0.0204 0.1137 0.1649
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0035 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0088 0.0088
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.003 0.0038
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1197 0.6872 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0166 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Echinococcus granulosus lamin 0.0032 0.0142 0.02
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.0038
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0158 0.8223
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0128 0.0696 0.1045
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.1154 0.6623 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0138 0.0195
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0069 0.0095
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0103 0.0144
Mycobacterium leprae Probable lipase LipE 0.0035 0.0159 0.0153
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0069 0.0095
Mycobacterium ulcerans hydrolase 0.001 0.0016 0.0003
Echinococcus granulosus hypothetical protein 0.0204 0.1137 0.1649
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0204 0.1137 0.1188
Onchocerca volvulus 0.0035 0.0159 0.098
Echinococcus multilocularis neuropeptide receptor 0.0204 0.1137 0.1649
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0008 0.0004 0.0004
Echinococcus granulosus orexin receptor type 2 0.0204 0.1137 0.1649
Echinococcus multilocularis G protein coupled receptor 139 0.0204 0.1137 0.1649
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0088 0.0122
Schistosoma mansoni lamin 0.0032 0.0142 0.0144
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0088 0.0088
Schistosoma mansoni carbonic anhydrase 0.1659 0.954 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.003 0.0038
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0191 0.6764
Echinococcus multilocularis rhodopsin orphan GPCR 0.0204 0.1137 0.1649
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0204 0.1137 0.1649
Echinococcus multilocularis dro:myosuppressin receptor 0.0204 0.1137 0.1649
Schistosoma mansoni biogenic amine (5HT) receptor 0.0636 0.3633 0.3806
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0527 0.3003 0.4367
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0088 0.0122
Mycobacterium tuberculosis Probable dehydrogenase 0.0128 0.0696 0.1045
Echinococcus multilocularis 6 phosphofructokinase 0.0129 0.0702 0.1016
Loa Loa (eye worm) hypothetical protein 0.0035 0.0159 0.0225
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0204 0.1137 0.1649
Brugia malayi hypothetical protein 0.0204 0.1137 0.1649
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.0088 0.0088
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0039 0.0051
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.0158 0.0161
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0166 0.0169
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0069 0.0217
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0012 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0016
Onchocerca volvulus Glucosylceramidase homolog 0.0177 0.0981 0.6181
Brugia malayi Sulfatase family protein 0.001 0.0016 0.0017
Brugia malayi neuropeptide F receptor 0.0204 0.1137 0.1649
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0159 0.0159
Brugia malayi hypothetical protein 0.0023 0.0088 0.0122
Echinococcus granulosus dnaJ subfamily B 0.0468 0.2659 0.3865
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0204 0.1137 0.1188
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0981 0.0981
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0175 0.0175
Onchocerca volvulus 0.0204 0.1137 0.7169
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0007 0.0004
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0088 0.0088
Echinococcus multilocularis allatostatin A receptor 0.0204 0.1137 0.1649
Brugia malayi larval opioid receptor 0.0204 0.1137 0.1649
Brugia malayi beta-lactamase 0.0035 0.0159 0.0225
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0204 0.1137 0.7169
Brugia malayi phosphofructokinase 0.0129 0.0702 0.1016
Echinococcus granulosus ferritin 0.001 0.0013 0.0013
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0158 1
Echinococcus multilocularis g protein coupled receptor 0.0204 0.1137 0.1649
Loa Loa (eye worm) hypothetical protein 0.002 0.0074 0.0101
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0035 0.0045
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.0088 0.0122
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Echinococcus granulosus dro:myosuppressin receptor 0.0204 0.1137 0.1649
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0088 0.0088
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.1074 0.6163 0.9305
Entamoeba histolytica hypothetical protein 0.0023 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Loa Loa (eye worm) RGS-3 protein 0.0023 0.0088 0.0122
Loa Loa (eye worm) hypothetical protein 0.0527 0.3003 0.4367
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0437 0.248 0.3605
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0128 0.0696 0.1045
Echinococcus multilocularis Smad4 0.0009 0.001 0.0008
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0088 0.0122
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0017 0.0043
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0147 0.0207
Schistosoma mansoni lamin 0.0032 0.0142 0.0144
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0056 0.0075
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0088 0.0122
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0155 0.0219
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0069 0.3153
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0103 0.0103
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0477 0.2713 0.3944
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.003 0.0038
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1197 0.6872 0.7202
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0069 0.0095
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.1517 0.1517
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0017 0.0019
Onchocerca volvulus 0.0035 0.0159 0.098
Echinococcus multilocularis rhodopsin orphan GPCR 0.0204 0.1137 0.1649
Leishmania major carbonic anhydrase-like protein 0.1197 0.6872 0.7202
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0007 0.0004
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0128 0.0696 0.1045
Entamoeba histolytica phosphofructokinase, putative 0.0129 0.0702 0.0731
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0204 0.1137 0.1649
Brugia malayi PXA domain containing protein 0.0023 0.0088 0.0122
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0019
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0038 0.0038
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0175 0.0571
Brugia malayi Serotonin receptor 0.0204 0.1137 0.1649
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0204 0.1137 0.1188
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0039 0.0051
Loa Loa (eye worm) RecQ helicase 0.0025 0.0103 0.0144
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0166 0.0235
Echinococcus multilocularis cpg binding protein 0.0035 0.0158 0.0223
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0204 0.1137 0.1188
Plasmodium falciparum glutathione reductase 0.0019 0.0069 0.0217
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0017 0.0019
Echinococcus granulosus 6 phosphofructokinase 0.0129 0.0702 0.1016
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Schistosoma mansoni smad1 5 8 and 0.0009 0.001 0.0006
Toxoplasma gondii exonuclease III APE 0.0041 0.0191 0.0624
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0088 0.0122
Echinococcus multilocularis musashi 0.0032 0.0142 0.02
Schistosoma mansoni alpha-1 adrenergic receptor 0.0204 0.1137 0.1188
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0159 0.0159
Brugia malayi sulfakinin receptor protein 0.0204 0.1137 0.1649
Onchocerca volvulus 0.0204 0.1137 0.7169
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0204 0.1137 0.1649
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0017 0.0019
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0088 0.0088
Echinococcus multilocularis sex peptide receptor 0.0204 0.1137 0.1649
Echinococcus multilocularis fmrfamide receptor 0.0204 0.1137 0.1649
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0166 0.0235
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0122
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0437 0.248 0.3605
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0158 0.5562
Brugia malayi Pre-SET motif family protein 0.0036 0.0166 0.0235
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0175 0.0249
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0035 0.0035
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0009 0.0007 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0204 0.1137 0.1649
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0191 0.0272
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0007 0.0007
Echinococcus granulosus carbonic anhydrase II 0.1197 0.6872 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0038 0.005
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0069 0.0068
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0204 0.1137 0.1649
Giardia lamblia Hypothetical protein 0.001 0.0016 0.0613
Brugia malayi hypothetical protein 0.0204 0.1137 0.1649
Echinococcus multilocularis serotonin receptor 0.0636 0.3633 0.5284
Loa Loa (eye worm) hypothetical protein 0.0204 0.1137 0.1649
Echinococcus granulosus microtubule associated protein 2 0.0818 0.4685 0.6816
Schistosoma mansoni ferritin 0.001 0.0013 0.0009
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0088 0.0122
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.027 0.1517 0.2203

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 81 nM Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane ChEMBL. 18318468
IC50 (binding) = 81 nM Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane ChEMBL. 18318468

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.