Detailed information for compound 54296

Basic information

Technical information
  • TDR Targets ID: 54296
  • Name: 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-(2 -methyl-3-oxobutan-2-yl)oxybenzamide
  • MW: 369.886 | Formula: C18H28ClN3O3
  • H donors: 2 H acceptors: 2 LogP: 2.23 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCNC(=O)c1cc(Cl)c(cc1OC(C(=O)C)(C)C)N)CC
  • InChi: 1S/C18H28ClN3O3/c1-6-22(7-2)9-8-21-17(24)13-10-14(19)15(20)11-16(13)25-18(4,5)12(3)23/h10-11H,6-9,20H2,1-5H3,(H,21,24)
  • InChiKey: QRUGIBFAVQDPIS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-(1,1-dimethyl-2-oxo-propoxy)benzamide
  • 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-(1,1-dimethyl-2-oxopropoxy)benzamide
  • 4-azanyl-5-chloro-N-(2-diethylaminoethyl)-2-(2-methyl-3-oxo-butan-2-yl)oxy-benzamide
  • 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-(2-keto-1,1-dimethyl-propoxy)benzamide
  • 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-(2-methyl-3-oxo-butan-2-yl)oxy-benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine D2 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis serotonin receptor Dopamine D2 receptor   444 aa 428 aa 31.3 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Dopamine D2 receptor   444 aa 487 aa 23.8 %
Schistosoma japonicum Octopamine receptor, putative Dopamine D2 receptor   444 aa 456 aa 29.4 %
Onchocerca volvulus Dopamine D2 receptor   444 aa 418 aa 23.0 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Dopamine D2 receptor   444 aa 386 aa 19.7 %
Echinococcus granulosus g protein coupled receptor Dopamine D2 receptor   444 aa 457 aa 21.0 %
Echinococcus multilocularis g protein coupled receptor Dopamine D2 receptor   444 aa 465 aa 21.5 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Dopamine D2 receptor   444 aa 476 aa 24.2 %
Echinococcus granulosus biogenic amine 5HT receptor Dopamine D2 receptor   444 aa 429 aa 31.7 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Dopamine D2 receptor   444 aa 432 aa 30.8 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Dopamine D2 receptor   444 aa 440 aa 30.0 %
Loa Loa (eye worm) hypothetical protein Dopamine D2 receptor   444 aa 433 aa 21.2 %
Schistosoma mansoni biogenic amine receptor Dopamine D2 receptor   444 aa 452 aa 30.1 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Dopamine D2 receptor   444 aa 474 aa 23.4 %
Schistosoma mansoni amine GPCR Dopamine D2 receptor   444 aa 424 aa 32.1 %
Schistosoma mansoni biogenic amine (dopamine) receptor Dopamine D2 receptor   444 aa 494 aa 26.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.011 0.0119 0.1145
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0145 0.0164 0.1076
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.005 0.0043 0.0412
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0181
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0125 0.0139 0.1272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0165 0.0189 0.176
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0021 0.0021
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0388 0.0471 0.4476
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0025 0.0011 0.0084
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0122
Brugia malayi Pre-SET motif family protein 0.0226 0.0266 0.255
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0713 0.0882 0.2538
Trichomonas vaginalis PIKK family atypical protein kinase 0.0231 0.0272 0.2562
Entamoeba histolytica protein kinase, putative 0.0056 0.0051 0.0425
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0021 0.0139
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0145 0.0164 0.1569
Loa Loa (eye worm) RecQ helicase 0.0023 0.0009 0.0069
Echinococcus granulosus casein kinase ii subunit alpha 0.015 0.017 0.017
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0145 0.0164 0.1924
Brugia malayi Death domain containing protein 0.0016 0.000000005167 0.000000049498
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0232 0.0274 0.0274
Entamoeba histolytica hypothetical protein 0.0039 0.003 0.0225
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0007 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0021 0.0139
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0713 0.0882 0.2411
Schistosoma mansoni single-minded 0.0053 0.0048 0.0312
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0087 0.009 0.0806
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0702 0.0869 0.5707
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.005 0.0043 0.035
Echinococcus granulosus geminin 0.0184 0.0213 0.0213
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.7921 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0125 0.0139 0.1272
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0035 0.0025 0.0025
Trichomonas vaginalis CMGC family protein kinase 0.015 0.017 0.1574
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0376 0.0456 0.4369
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0007 0.0064
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Loa Loa (eye worm) hypothetical protein 0.0136 0.0152 0.1124
Plasmodium falciparum casein kinase II beta chain 0.004 0.0031 0.0933
Brugia malayi intracellular kinase 0.0056 0.0051 0.0486
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0007 0.0007
Giardia lamblia Kinase, CMGC GSK 0.0056 0.0051 0.0348
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0145 0.0164 0.1515
Loa Loa (eye worm) phosphatidylinositol 3 0.1086 0.1354 1
Brugia malayi SH2 domain containing protein 0.0373 0.0451 0.4324
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.005 0.0043 0.035
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Brugia malayi M-phase phosphoprotein, mpp8 0.011 0.0119 0.1143
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0007 0.0007
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0136 0.0152 0.1
Onchocerca volvulus 0.0258 0.0306 0.7191
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.0166 0.1088
Loa Loa (eye worm) hypothetical protein 0.0179 0.0206 0.1524
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0021 0.0021
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0007 0.0007
Onchocerca volvulus Casein kinase II subunit beta homolog 0.004 0.0031 0.0725
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0271 0.0323 0.0323
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0074 0.0074 0.5397
Onchocerca volvulus Serine\/threonine kinase homolog 0.021 0.0246 0.5778
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0007 0.0007
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0365 0.0442 0.4233
Loa Loa (eye worm) hypothetical protein 0.0032 0.0021 0.0156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0673 0.0831 0.7947
Loa Loa (eye worm) phosphatidylinositol 3 0.0145 0.0164 0.1209
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0052 0.0046 0.0378
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1219 0.1522 0.1522
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0232 0.0274 0.1799
Brugia malayi Pre-SET motif family protein 0.0032 0.0021 0.0202
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0376 0.0456 0.0456
Entamoeba histolytica hypothetical protein 0.0145 0.0164 0.1515
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0352 0.0425 0.4075
Loa Loa (eye worm) hypothetical protein 0.0036 0.0025 0.0188
Giardia lamblia Kinase, CMGC GSK 0.0056 0.0051 0.0348
Giardia lamblia GTOR 0.0713 0.0882 1
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0007 0.0007
Plasmodium falciparum casein kinase II beta chain 0.004 0.0031 0.0933
Brugia malayi Cytochrome P450 family protein 0.0021 0.0007 0.0066
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Giardia lamblia Casein kinase II beta chain 0.004 0.0031 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0139 0.1272
Brugia malayi serine/threonine-protein kinase plk-2 0.021 0.0246 0.2355
Trypanosoma cruzi target of rapamycin kinase 3 0.0693 0.0856 0.2465
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.015 0.017 0.1255
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0693 0.0856 0.2341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0673 0.0831 0.7947
Echinococcus multilocularis survival motor neuron protein 1 0.0516 0.0633 0.0633
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0119 0.0131 0.7613
Onchocerca volvulus 0.0029 0.0017 0.0403
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0009 0.009
Echinococcus granulosus serine protein kinase ATM 0.0392 0.0476 0.0476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0713 0.0882 0.8437
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0087 0.009 0.0806
Onchocerca volvulus 0.0045 0.0037 0.0865
Brugia malayi PAS domain containing protein 0.0053 0.0048 0.0455
Loa Loa (eye worm) hypothetical protein 0.011 0.0119 0.0882
Loa Loa (eye worm) Csnk2b protein 0.004 0.0031 0.0228
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0007 0.0044
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0145 0.0164 0.0164
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0007 0.0007
Trichomonas vaginalis CMGC family protein kinase 0.015 0.017 0.1574
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0145 0.0164 0.1793
Entamoeba histolytica hypothetical protein 0.0145 0.0164 0.1515
Brugia malayi hypothetical protein 0.0021 0.0007 0.0064
Echinococcus granulosus lamin dm0 0.0029 0.0017 0.0017
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0232 0.0274 0.2624
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0007 0.0013
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0051 0.0425
Trichomonas vaginalis PIKK family atypical protein kinase 0.0647 0.0799 0.7639
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0007 0.0007
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0007 0.0007
Entamoeba histolytica casein kinase, putative 0.015 0.017 0.1574
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0087 0.009 0.0254
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0841 0.1044 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.004
Entamoeba histolytica hypothetical protein 0.0392 0.0476 0.4528
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.015 0.017 0.5893
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0392 0.0476 0.4563
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.005 0.0043 0.0043
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0021 0.0136
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.021 0.0246 0.0668
Onchocerca volvulus 0.0145 0.0164 0.385
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0035 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0105 0.0113 0.0744
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.003 0.003
Echinococcus multilocularis voltage dependent calcium channel 0.0035 0.0025 0.0025
Loa Loa (eye worm) phosphatidylinositol 3 0.0713 0.0882 0.6511
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0087 0.009 0.0593
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0436 0.0532 0.6004
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0007 0.0044
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Onchocerca volvulus Casein kinase II subunit beta homolog 0.004 0.0031 0.0725
Echinococcus granulosus serine:threonine protein kinase PLK1 0.021 0.0246 0.0246
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0025 0.1497
Mycobacterium ulcerans putative regulatory protein 0.0039 0.003 0.1861
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0087 0.009 0.0806
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0021 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Loa Loa (eye worm) hypothetical protein 0.0029 0.0017 0.0127
Onchocerca volvulus 0.0105 0.0113 0.2662
Brugia malayi Cytochrome P450 family protein 0.0033 0.0021 0.0203
Leishmania major casein kinase II, putative 0.015 0.017 0.046
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0087 0.009 0.0254
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0232 0.0274 0.3221
Brugia malayi Uncoordinated protein 44 0.0016 0.000000005167 0.000000049498
Entamoeba histolytica serine/threonine protein kinase, putative 0.021 0.0246 0.2306
Echinococcus multilocularis casein kinase ii subunit beta 0.004 0.0031 0.0031
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0105 0.0113 0.1085
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0702 0.0869 0.0869
Loa Loa (eye worm) hypothetical protein 0.0416 0.0507 0.3742
Trichomonas vaginalis CMGC family protein kinase 0.015 0.017 0.1574
Trichomonas vaginalis PIKK family atypical protein kinase 0.0388 0.0471 0.4476
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0035 0.0025 0.0025
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0365 0.0442 0.4196
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0702 0.0869 0.8322
Echinococcus multilocularis casein kinase ii subunit alpha 0.015 0.017 0.017
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0232 0.0274 0.0274
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0021 0.0136
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0021 0.0241
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0114 0.1031
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0841 0.1044 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0185 0.0215 0.2374
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0131 0.1197
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0147 0.0166 0.1222
Echinococcus granulosus survival motor neuron protein 1 0.0516 0.0633 0.0633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0392 0.0476 0.4528
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0145 0.0164 0.1515
Onchocerca volvulus 0.0054 0.0049 0.1143
Trichomonas vaginalis conserved hypothetical protein 0.0231 0.0272 0.2562
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.004 0.0031 0.036
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0087 0.009 0.009
Loa Loa (eye worm) gastrulation defective protein 1 0.0143 0.0161 0.1188
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0232 0.0274 1
Leishmania major phosphatidylinositol 4-kinase, putative 0.0145 0.0164 0.0443
Trichomonas vaginalis PIKK family atypical protein kinase 0.0688 0.085 0.813
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0618 0.0762 0.0762
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0087 0.009 0.0806
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1219 0.1522 0.1522
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0011 0.0074
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0637 0.0786 0.7517
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0025 0.0011 0.0109
Plasmodium vivax glycogen synthase kinase 3, putative 0.0056 0.0051 0.1183
Giardia lamblia Kinase, CMGC CK2 0.015 0.017 0.1732
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.0824 0.7885
Plasmodium vivax SET domain protein, putative 0.0032 0.0021 0.0013
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0087 0.009 0.0806
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0131 0.0966
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0035 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0039 0.003 0.0197
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0659 0.0814 0.2224
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0026
Loa Loa (eye worm) phosphatidylinositol 3 0.0145 0.0164 0.1209
Brugia malayi Protein kinase domain containing protein 0.0147 0.0166 0.1586
Trichomonas vaginalis PIKK family atypical protein kinase 0.0145 0.0164 0.1515
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0232 0.0274 0.2577
Loa Loa (eye worm) hypothetical protein 0.0376 0.0456 0.3367
Brugia malayi hypoxia-induced factor 1 0.0165 0.0189 0.1809
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0087 0.009 0.0806
Onchocerca volvulus 0.0145 0.0164 0.385
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0647 0.0799 0.9053
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0145 0.0164 0.1076
Leishmania major hypothetical protein, unknown function 0.0145 0.0164 0.0443
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0131 0.1197
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0378 0.0458 0.4392
Echinococcus granulosus expressed protein 0.0409 0.0498 0.0498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0659 0.0814 0.7782
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0145 0.0164 0.0164
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.0038 0.0028 0.0245
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0049
Trichomonas vaginalis CMGC family protein kinase 0.015 0.017 0.1574
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0145 0.0164 0.1569
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.004 0.0031 0.0082
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0196 0.0228 0.1683
Loa Loa (eye worm) hypothetical protein 0.0271 0.0323 0.2385
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0087 0.009 0.0806
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0713 0.0882 0.8447
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0415 0.0505 0.4803
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0696 0.086 0.8229
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0713 0.0882 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0647 0.0799 0.7639
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0392 0.0476 0.3129
Loa Loa (eye worm) phosphofructokinase 0.0119 0.0131 0.0966
Echinococcus multilocularis Zinc finger, PHD finger 0.0232 0.0274 0.0274
Toxoplasma gondii hypothetical protein 0.0036 0.0025 0.0297
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0232 0.0274 0.1799
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0713 0.0882 0.2411
Leishmania major hypothetical protein, conserved 0.0038 0.0028 0.0071
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0007 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0271 0.0323 0.305
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Trichomonas vaginalis CMGC family protein kinase 0.015 0.017 0.1574
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0051 0.0425
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0352 0.0425 0.3141
Trypanosoma brucei Casein kinase II subunit beta, putative 0.004 0.0031 0.0273
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0035 0.0025 0.0235
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0021 0.0557
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0056 0.0051 0.0133
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0087 0.009 0.0806
Schistosoma mansoni kinase 0.0108 0.0117 0.0769
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0889 0.1104 0.1104
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0232 0.0274 0.0784
Loa Loa (eye worm) phosphatidylinositol 3 0.0145 0.0164 0.1209
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.000000005167 0.000000005167
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0056 0.0051 0.014
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0038 0.0028 0.0075
Echinococcus multilocularis 6 phosphofructokinase 0.0119 0.0131 0.0131
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0021 0.0136
Loa Loa (eye worm) hypothetical protein 0.005 0.0043 0.0316
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0131 0.0859
Leishmania major phosphatidylinositol kinase related protein, putative 0.0161 0.0184 0.0498
Echinococcus granulosus single minded 2 0.0039 0.003 0.003
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0007 0.0044
Plasmodium vivax unspecified product 0.015 0.017 0.5893
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0007 0.0044
Echinococcus granulosus expressed conserved protein 0.0089 0.0093 0.0093
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0007 0.0044
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.021 0.0246 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0073 0.0637
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0145 0.0164 0.5649
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0007 0.0064
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0056 0.0051 0.0375
Onchocerca volvulus 0.0039 0.003 0.0705
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Onchocerca volvulus 0.011 0.0119 0.2805
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0841 0.1044 0.3006
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.0824 0.7885
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0352 0.0425 0.3141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0416 0.0507 0.4823
Plasmodium vivax casein kinase II beta chain, putative 0.004 0.0031 0.0398
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0365 0.0442 0.4196
Echinococcus multilocularis expressed conserved protein 0.005 0.0043 0.0043
Echinococcus multilocularis 0.0145 0.0164 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0693 0.0856 0.8192
Echinococcus granulosus protein kinase shaggy 0.0056 0.0051 0.0051
Entamoeba histolytica hypothetical protein 0.0039 0.003 0.0225
Echinococcus granulosus cyclin dependent kinase 19 0.0147 0.0166 0.0166
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0131 0.1197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0647 0.0799 0.7639
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0007 0.0051
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0035 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0416 0.0507 0.4821
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0098 0.0104 0.0681
Plasmodium vivax casein kinase II beta chain, putative 0.004 0.0031 0.0398
Echinococcus granulosus casein kinase ii subunit beta 0.004 0.0031 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0688 0.085 0.813
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0365 0.0442 0.4196
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0131 0.0371
Schistosoma mansoni intermediate filament proteins 0.0029 0.0017 0.0113
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0702 0.0869 0.2501
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0021 0.0241
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0693 0.0856 0.971
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0017 0.0127
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0145 0.0164 0.1569
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0145 0.0164 0.0466
Trypanosoma cruzi polo-like protein kinase, putative 0.021 0.0246 0.0703
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0049
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0051 0.0425
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.000000005167 0.000000005167
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0713 0.0882 0.0882
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0025 0.0185
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0031 0.0233
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0028 0.0209
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0841 0.1044 0.3006
Entamoeba histolytica hypothetical protein 0.0145 0.0164 0.1515
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0131 0.0966
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0087 0.009 0.0806
Plasmodium falciparum GAF domain-related protein, putative 0.0036 0.0025 0.0732
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Trichomonas vaginalis CMGC family protein kinase 0.015 0.017 0.1574
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0095 0.01 0.01
Echinococcus multilocularis expressed conserved protein 0.0089 0.0093 0.0093
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0713 0.0882 0.8437
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0035 0.0025 0.0161
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0049
Schistosoma mansoni hypothetical protein 0.0271 0.0323 0.2122
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0017 0.0127
Plasmodium vivax hypothetical protein, conserved 0.0145 0.0164 0.5649
Trichomonas vaginalis CAMK family protein kinase 0.021 0.0246 0.2306
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0352 0.0425 0.0425
Plasmodium falciparum casein kinase 2, alpha subunit 0.015 0.017 0.6121
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0145 0.0164 0.1076
Trichomonas vaginalis CAMK family protein kinase 0.021 0.0246 0.2306
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0021 0.0136
Brugia malayi Serotonin receptor 0.0514 0.063 0.6038
Loa Loa (eye worm) hypothetical protein 0.0516 0.0633 0.4674
Toxoplasma gondii target of rapamycin (TOR), putative 0.0688 0.085 1
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0007 0.0007
Loa Loa (eye worm) calcium channel 0.0035 0.0025 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0376 0.0456 0.4333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0688 0.085 0.813
Loa Loa (eye worm) hypothetical protein 0.0272 0.0324 0.2396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.0824 0.7884
Brugia malayi hypothetical protein 0.0039 0.003 0.0287
Schistosoma mansoni lamin 0.0029 0.0017 0.0113
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0713 0.0882 0.8437
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0038 0.0028 0.0075
Schistosoma mansoni lamin 0.0029 0.0017 0.0113
Echinococcus multilocularis tumor protein p63 0.037 0.0449 0.0449
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0365 0.0442 0.4196
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0073 0.0637
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0007 0.0044
Loa Loa (eye worm) hypoxia-induced factor 1 0.0165 0.0189 0.1394
Trichomonas vaginalis PIKK family atypical protein kinase 0.0688 0.085 0.813
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0009 0.0064
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0095 0.01 0.01
Echinococcus granulosus voltage dependent calcium channel 0.0035 0.0025 0.0025
Onchocerca volvulus 0.0056 0.0051 0.1193
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0145 0.0164 0.0466
Entamoeba histolytica protein kinase domain containing protein 0.0056 0.0051 0.0425
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Echinococcus multilocularis high voltage activated calcium channel beta 0.0095 0.01 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.2756 0.3467 1
Brugia malayi PXA domain containing protein 0.0023 0.0009 0.0082
Schistosoma mansoni hypothetical protein 0.0145 0.0164 0.1076
Echinococcus granulosus beta-adrenergic receptor kinase 0.0025 0.0011 0.0011
Schistosoma mansoni casein kinase II beta subunit 0.004 0.0031 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0688 0.085 0.813
Loa Loa (eye worm) hypothetical protein 0.0016 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0145 0.0164 0.1515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.0824 0.7884
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0145 0.0164 0.1924
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0025 0.0182
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0702 0.0869 0.2501
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0232 0.0274 0.2577
Toxoplasma gondii hypothetical protein 0.0036 0.0025 0.0297
Toxoplasma gondii ck2 beta subunit 0.004 0.0031 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0693 0.0856 0.8192
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0145 0.0164 0.0466
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.021 0.0246 0.1815
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0618 0.0762 0.0762
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0098 0.0104 0.0104
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0232 0.0274 0.2577
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0365 0.0442 0.4972
Brugia malayi Protein kinase domain containing protein 0.0352 0.0425 0.4075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0647 0.0799 0.7639
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0021 0.0139
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0232 0.0274 0.2022
Giardia lamblia Hypothetical protein 0.0145 0.0164 0.1661
Trichomonas vaginalis PIKK family atypical protein kinase 0.0693 0.0856 0.8192
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0007 0.0007
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0051 0.0045 0.0368
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0145 0.0164 0.0164
Schistosoma mansoni serine/threonine protein kinase 0.021 0.0246 0.1615
Echinococcus granulosus bloom syndrome protein 0.0023 0.0009 0.0009
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0713 0.0882 0.0882
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0131 0.1197
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0051 0.0045 0.0123
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0232 0.0274 0.0274
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Brugia malayi phosphofructokinase 0.0119 0.0131 0.1253
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0119 0.0131 1
Schistosoma mansoni survival motor neuron protein 0.0105 0.0113 0.0744
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0007 0.0064
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0352 0.0425 0.0425
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0505 0.0618 0.694
Entamoeba histolytica protein kinase domain containing protein 0.015 0.017 0.1574
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0376 0.0456 0.131
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0011 0.0074
Giardia lamblia Phosphatidylinositol 4-kinase 0.0145 0.0164 0.1661
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0376 0.0456 0.0456
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0637 0.0786 0.7517
Echinococcus granulosus expressed conserved protein 0.005 0.0043 0.0043
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.002 0.002
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0021 0.0241
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0232 0.0274 0.2577
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0021 0.0245
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0007 0.0044
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0145 0.0164 0.1515
Echinococcus granulosus lamin 0.0029 0.0017 0.0017
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0021 0.0136
Echinococcus granulosus 6 phosphofructokinase 0.0119 0.0131 0.0131
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0007 0.0051
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0417 0.0508 0.3337
Plasmodium falciparum glycogen synthase kinase 3 0.0056 0.0051 0.1675
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0009 0.0027
Onchocerca volvulus 0.011 0.0119 0.2805
Brugia malayi hypothetical protein 0.0021 0.0007 0.0064
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0087 0.009 0.0952
Brugia malayi hypothetical protein 0.005 0.0043 0.0409
Entamoeba histolytica protein kinase rad3, putative 0.0376 0.0456 0.4333
Brugia malayi PXA domain containing protein 0.0023 0.0009 0.0082
Loa Loa (eye worm) phosphatidylinositol 3 0.0659 0.0814 0.601
Toxoplasma gondii GAF domain-containing protein 0.0036 0.0025 0.0297
Toxoplasma gondii hypothetical protein 0.0073 0.0073 0.0853
Trypanosoma cruzi casein kinase II, putative 0.015 0.017 0.0484
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0056 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0184 0.0213 0.14
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0145 0.0164 0.0466
Trichomonas vaginalis CAMK family protein kinase 0.021 0.0246 0.2306
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0119 0.0131 0.7613
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0145 0.0164 0.0164
Leishmania major protein kinase ck2 regulatory subunit, putative 0.004 0.0031 0.0078
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0007 0.0013
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0232 0.0274 0.0784
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0713 0.0882 0.2538
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0278 0.0332 0.3612
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.003 0.003
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0262 0.0311 0.2299
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0087 0.009 0.009
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.0266 0.1966
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0021 0.0021
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0713 0.0882 1
Mycobacterium leprae conserved hypothetical protein 0.0145 0.0164 1
Trichomonas vaginalis CAMK family protein kinase 0.021 0.0246 0.2306
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0708 0.0876 0.8381
Entamoeba histolytica hypothetical protein 0.0708 0.0876 0.8381
Trichomonas vaginalis CAMK family protein kinase 0.021 0.0246 0.2306
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0161 0.0184 0.0525
Loa Loa (eye worm) hypothetical protein 0.005 0.0043 0.0316
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0841 0.1044 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0037 0.0242
Echinococcus multilocularis beta adrenergic receptor kinase 0.0025 0.0011 0.0011
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0007 0.0007
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.022 0.0258 0.0739
Echinococcus multilocularis serine protein kinase ATM 0.0392 0.0476 0.0476
Schistosoma mansoni voltage-gated cation channel 0.0035 0.0025 0.0161
Leishmania major phosphatidylinositol 3-kinase, putative 0.0647 0.0799 0.2184
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0021 0.0136
Brugia malayi 6-phosphofructokinase 0.0119 0.0131 0.1253
Plasmodium vivax hypothetical protein 0.0145 0.0164 0.5649
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0659 0.0814 0.9223
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0436 0.0531 0.506
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0035 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0145 0.0164 0.1209
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.000000005167 0.000000033943
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0392 0.0476 0.5365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0422 0.0513 0.4885
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0247 0.0293 0.0838
Echinococcus multilocularis geminin 0.0184 0.0213 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0693 0.0856 0.8192
Echinococcus multilocularis expressed protein 0.0409 0.0498 0.0498
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0035 0.0025 0.0161
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0713 0.0882 0.8437
Trichomonas vaginalis PIKK family atypical protein kinase 0.0693 0.0856 0.8192
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0392 0.0476 0.1368
Echinococcus granulosus tumor protein p63 0.037 0.0449 0.0449
Trichomonas vaginalis CMGC family protein kinase 0.015 0.017 0.1574
Giardia lamblia Kinase, PLK 0.021 0.0246 0.2614
Leishmania major phosphatidylinositol kinase, putative 0.0145 0.0164 0.0443
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.005 0.0043 0.035
Brugia malayi bHLH-PAS transcription factor 0.0039 0.003 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0416 0.0507 0.4823
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0007 0.0049
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0007 0.0064
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.0082 0.0082
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0035 0.0025 0.0025
Trypanosoma cruzi polo-like protein kinase, putative 0.021 0.0246 0.0703
Entamoeba histolytica hypothetical protein 0.0039 0.003 0.0225
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0011 0.0074
Brugia malayi 6-phosphofructokinase 0.0119 0.0131 0.1253
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0003 0.0021
Toxoplasma gondii CMGC kinase, CK2 family 0.015 0.017 0.1997
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0621 0.0766 0.7334
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0145 0.0164 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0688 0.085 0.813
Brugia malayi intermediate filament protein 0.0029 0.0017 0.0164
Mycobacterium tuberculosis Conserved hypothetical protein 0.0145 0.0164 1
Leishmania major cytochrome p450-like protein 0.0021 0.0007 0.0013
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Echinococcus multilocularis lamin 0.0029 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0073 0.0637
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0087 0.009 0.0806
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0365 0.0442 0.1269
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0007 0.0044
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0049 0.032
Trichomonas vaginalis casein kinase II beta chain, putative 0.004 0.0031 0.0233
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.003 0.0197
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0054 0.0049 0.0359
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0145 0.0164 0.5892
Schistosoma mansoni hypothetical protein 0.0184 0.0213 0.14
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0416 0.0507 0.5961
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0007 0.0044
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0131 0.1197
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0021 0.0157
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0145 0.0164 0.1924
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.0824 0.7885
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0087 0.009 0.0952
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0056 0.0051 0.0051
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0702 0.0869 0.0869
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0025 0.0011 0.0084
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0095 0.01 0.0659
Trichomonas vaginalis PIKK family atypical protein kinase 0.0442 0.0539 0.5131
Brugia malayi Protein kinase domain containing protein 0.0019 0.0005 0.0045
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0098 0.0104 0.0104
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0021 0.0557
Brugia malayi hypothetical protein 0.005 0.0043 0.0409
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0007 0.0007
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0007 0.0044
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0056 0.0051 0.0375
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0131 0.0859
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0056 0.0051 0.0594
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0021 0.0136
Schistosoma mansoni hypothetical protein 0.0056 0.0051 0.0336
Brugia malayi Cytochrome P450 family protein 0.0021 0.0007 0.0066
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0007 0.0064
Trichomonas vaginalis set domain proteins, putative 0.0257 0.0306 0.2884
Trypanosoma brucei polo-like protein kinase 0.021 0.0246 0.2731
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1219 0.1522 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0 0.0001
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0352 0.0425 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0688 0.085 0.813
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0145 0.0164 0.5649
Trichomonas vaginalis PIKK family atypical protein kinase 0.0416 0.0507 0.4823
Echinococcus multilocularis lamin dm0 0.0029 0.0017 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.021 0.0246 0.2306
Trichomonas vaginalis CAMK family protein kinase 0.021 0.0246 0.2306
Loa Loa (eye worm) hypothetical protein 0.0618 0.0762 0.563
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0009 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.0824 0.7884
Loa Loa (eye worm) phosphatidylinositol 3 0.022 0.0258 0.1906
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.005 0.0043 0.0043
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0131 0.1415
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0021 0.5
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0007 0.0007
Brugia malayi FAT domain containing protein 0.0271 0.0323 0.3094
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0145 0.0164 0.5649
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0049
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0031 0.0233
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0048 0.0312
Toxoplasma gondii FATC domain-containing protein 0.0392 0.0476 0.5603
Brugia malayi hypothetical protein 0.0179 0.0206 0.1977
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.004 0.0031 0.0233
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.0082 0.0082
Brugia malayi Casein kinase II, alpha chain 0.015 0.017 0.1628
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0052 0.0046 0.0378
Leishmania major ATP-dependent phosphofructokinase 0.0119 0.0131 0.0352
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0232 0.0274 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0125 0.0139 0.1272
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.004 0.0031 0.0082
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0136 0.0152 0.1458
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0145 0.0164 0.1793
Echinococcus multilocularis cyclin dependent kinase 19 0.0147 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.011 0.0119 0.0881
Echinococcus multilocularis protein kinase shaggy 0.0056 0.0051 0.0051
Leishmania major hypothetical protein, conserved 0.2902 0.3651 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0145 0.0164 0.1209
Loa Loa (eye worm) phosphatidylinositol 3 0.0145 0.0164 0.1209
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0007 0.0044
Brugia malayi follicle stimulating hormone receptor 0.0262 0.0311 0.2983
Onchocerca volvulus 0.0029 0.0017 0.0403
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0074 0.0074 0.3492
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0271 0.0323 0.0323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.0824 0.7885
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0025 0.1497
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0007 0.0007
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0232 0.0274 0.3221
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0713 0.0882 0.5793
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0049
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0021 0.0136
Trypanosoma brucei Casein kinase II 0.015 0.017 0.1863
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0052 0.0046 0.0341
Leishmania major phosphatidylinositol 3-kinase, putative 0.0232 0.0274 0.0744
Brugia malayi Csnk2b protein 0.004 0.0031 0.0296
Echinococcus granulosus high voltage activated calcium channel beta 0.0095 0.01 0.01
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0131 0.1197
Schistosoma mansoni serine/threonine protein kinase 0.0352 0.0425 0.2795
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0841 0.1044 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0232 0.0274 0.2577
Echinococcus multilocularis voltage dependent calcium channel 0.0035 0.0025 0.0025
Echinococcus multilocularis musashi 0.0029 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0462 0.0564 0.5374
Mycobacterium ulcerans 6-phosphofructokinase 0.0119 0.0131 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0232 0.0274 0.0744
Entamoeba histolytica hypothetical protein 0.0039 0.003 0.0225
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0087 0.009 0.0254
Brugia malayi hypothetical protein 0.0516 0.0633 0.6064
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0051 0.0045 0.0368
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.0114 0.1031
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0017 0.0164
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0056 0.0051 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0713 0.0882 0.8437
Schistosoma mansoni protein kinase 0.015 0.017 0.1116
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0049
Schistosoma mansoni hypothetical protein 0.0089 0.0093 0.0612
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0196 0.0228 0.2183
Trypanosoma brucei protein kinase, putative 0.0056 0.0051 0.0501
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0145 0.0164 0.5892
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0232 0.0274 0.3052
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0098 0.0104 0.0681
Schistosoma mansoni fkbp-rapamycin associated protein 0.0376 0.0456 0.2996
Loa Loa (eye worm) hypothetical protein 0.0247 0.0293 0.2161
Loa Loa (eye worm) hypothetical protein 0.0373 0.0451 0.3333
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.003 0.003
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0841 0.1044 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0007 0.0051
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0131 0.1197
Echinococcus granulosus intermediate filament protein 0.0029 0.0017 0.0017

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 3 mg kg-1 In vivo antagonism activity against dopamine D2 receptor was measured as emesis in dog when administered subcutaneously ChEMBL. 3397992
ED50 (functional) > 3 mg kg-1 In vivo antagonism activity against dopamine D2 receptor was measured as emesis in dog when administered subcutaneously ChEMBL. 3397992
ED50 (functional) > 40 mg kg-1 In vivo antagonistic activity against dopamine D2 receptor was measured as catalepsy in rat when administered subcutaneously ChEMBL. 3397992
ED50 (functional) > 40 mg kg-1 In vivo antagonism activity against D2 receptor was measured as stereotypy in rat when administered subcutaneously ChEMBL. 3397992
ED50 (functional) > 40 mg kg-1 In vivo antagonistic activity against dopamine D2 receptor was measured as catalepsy in rat when administered subcutaneously ChEMBL. 3397992
ED50 (functional) > 40 mg kg-1 In vivo antagonism activity against D2 receptor was measured as stereotypy in rat when administered subcutaneously ChEMBL. 3397992
Emetic episodes (functional) = 2.7 In vivo antagonism of cisplatin-induced emesis in dog measured as emetic episodes, twice the dose of 0.3 mg/kg in 2 dogs ChEMBL. 3397992
Emetic episodes (functional) = 2.7 In vivo antagonism of cisplatin-induced emesis in ferret measured as emetic episodes, twice the dose of 1 mg/kg and in 3 ferrets ChEMBL. 3397992
IC50 (binding) > 1000 nM In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]-spiperone binding ChEMBL. 3397992
IC50 (binding) > 1000 nM In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]-spiperone binding ChEMBL. 3397992
Protection (functional) = 62 % In vitro antagonism of cisplatin-induced emesis in ferret measured as percentage protection for twice the dose of 1 mg/kg and in 3 ferrets ChEMBL. 3397992
Protection (functional) = 77 % In vivo antagonism of cisplatin-induced emesis in dog measured as percentage protection for twice the dose of 0.3 mg/kg in 2 dogs ChEMBL. 3397992

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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