Detailed information for compound 59994

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 488.514 | Formula: C22H24N4O7S
  • H donors: 5 H acceptors: 9 LogP: 1.76 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccc(s1)C(=O)N[C@@H](C(=O)O)CCC(=O)O)Cc1ccc2c(c1)c(O)nc(n2)CO
  • InChi: 1S/C22H24N4O7S/c1-2-26(10-12-3-4-14-13(9-12)20(30)25-17(11-27)23-14)18-7-6-16(34-18)21(31)24-15(22(32)33)5-8-19(28)29/h3-4,6-7,9,15,27H,2,5,8,10-11H2,1H3,(H,24,31)(H,28,29)(H,32,33)(H,23,25,30)/t15-/m1/s1
  • InChiKey: WYHZLPKNEFOFDC-OAHLLOKOSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus thymidylate synthase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Get druggable targets OG5_127385 All targets in OG5_127385
Onchocerca volvulus Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania infantum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium ulcerans thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus granulosus thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus multilocularis thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum ko:K00560 thymidylate synthase [EC2.1.1.45], putative Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium yoelii thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Babesia bovis dihydrofolate reductase/thymidilate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Brugia malayi thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania major dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania donovani dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium hominis chain A, crystal structure of Dhfr Get druggable targets OG5_127385 All targets in OG5_127385
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Delta tubulin 0.0053 0.0859 0.1951
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Plasmodium vivax multidrug resistance protein 1, putative 0.0011 0.0014 0.0033
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0268 0.0621
Leishmania major beta tubulin 0.0223 0.4321 1
Plasmodium vivax vivapain-1 0.0221 0.4267 0.9875
Loa Loa (eye worm) tubulin alpha 2 0.0116 0.2153 0.3108
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0014 0.0014
Brugia malayi Tubulin beta chain 0.0053 0.0859 0.123
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1802 0.2598
Brugia malayi sulfakinin receptor protein 0.0068 0.1167 0.1676
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0441 0.0441
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0129 0.0308
Brugia malayi Cathepsin L-like precursor 0.0023 0.0258 0.0357
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.008 0.1423 0.2049
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0525 0.0525
Brugia malayi Doublecortin family protein 0.002 0.0195 0.0266
Brugia malayi Serotonin receptor 0.0068 0.1167 0.1676
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0258 0.0357
Loa Loa (eye worm) fibroinase 0.0023 0.0258 0.036
Schistosoma mansoni biogenic amine receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0011 0.002 0.002
Echinococcus granulosus dna polymerase kappa 0.0019 0.018 0.018
Onchocerca volvulus 0.0023 0.0258 0.0661
Onchocerca volvulus Cathepsin L homolog 0.0023 0.0258 0.0661
Echinococcus multilocularis g protein coupled receptor 0.0068 0.1167 0.1167
Brugia malayi hypothetical protein 0.0068 0.1167 0.1676
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0068 0.1167 0.1676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.018 0.0417
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0638 0.0638
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0268 0.0621
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.018 0.0417
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0441 0.1021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0011 0.002 0.0047
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Leishmania major DNA polymerase eta, putative 0.0019 0.018 0.0417
Loa Loa (eye worm) nuclear factor I 0.0013 0.0063 0.0077
Echinococcus multilocularis cathepsin L cysteine protease 0.0023 0.0258 0.0258
Plasmodium vivax delta tubulin, putative 0.0053 0.0859 0.1989
Leishmania major beta tubulin 0.0223 0.4321 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0169 0.3218 0.3218
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0638 0.0638
Echinococcus multilocularis tubulin alpha 0.0121 0.2247 0.2247
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.018 0.0417
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0148 0.036
Schistosoma mansoni alpha tubulin 0.0169 0.3218 0.3218
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0011 0.002 0.002
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0148 0.0344
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0493 0.1111
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.018 0.018
Schistosoma mansoni tubulin subunit delta 0.0053 0.0859 0.0859
Leishmania major beta tubulin 0.0223 0.4321 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0116 0.2153 0.3108
Echinococcus granulosus tubulin alpha 3 chain 0.0169 0.3218 0.3218
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.043 0.043
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.0092 0.0213
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0258 0.0596
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.002 0.002
Entamoeba histolytica P-glycoprotein-2, putative 0.0011 0.0014 0.0033
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0023 0.0258 0.0258
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0708 0.101
Onchocerca volvulus 0.0068 0.1167 0.31
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0493 0.1141
Leishmania major cathepsin L-like protease 0.0023 0.0258 0.0596
Echinococcus multilocularis somatostatin receptor 0.0068 0.1167 0.1167
Brugia malayi Dopamine receptor 0.0068 0.1167 0.1676
Trichomonas vaginalis tubulin beta chain, putative 0.0223 0.4321 1
Trypanosoma brucei beta tubulin 0.0223 0.4321 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Trypanosoma cruzi cysteine protease, putative 0.0023 0.0258 0.0596
Leishmania major beta tubulin 0.0223 0.4321 1
Schistosoma mansoni smad 0.0011 0.0011 0.0011
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0068 0.1167 0.1167
Echinococcus granulosus g protein coupled receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0011 0.002 0.002
Onchocerca volvulus 0.0023 0.0258 0.0661
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0258 0.0596
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0525 0.0525
Brugia malayi tubulin alpha-2 chain 0.0169 0.3218 0.465
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0014 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0708 0.0708
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0014 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0047
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0268 0.0621
Echinococcus granulosus alpha 1A adrenergic receptor 0.0068 0.1167 0.1167
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.1672 0.3848
Echinococcus multilocularis smad 0.0024 0.0279 0.0279
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0068 0.1182 0.2712
Schistosoma mansoni hypothetical protein 0.0503 1 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.2861 0.4133
Entamoeba histolytica cysteine proteinase 1, putative 0.0023 0.0258 0.0596
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Schistosoma mansoni multidrug resistance protein 0.0011 0.0014 0.0014
Schistosoma mansoni smdr2 0.0011 0.0014 0.0014
Echinococcus multilocularis RUN 0.002 0.0195 0.0195
Brugia malayi Cathepsin L-like precursor 0.0023 0.0258 0.0357
Schistosoma mansoni Smad4 0.0011 0.0011 0.0011
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Onchocerca volvulus 0.0068 0.1167 0.31
Trypanosoma brucei epsilon tubulin 0.0121 0.2247 0.52
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0091 0.1649 0.1649
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Schistosoma mansoni hypothetical protein 0.004 0.0608 0.0608
Schistosoma mansoni biogenic amine receptor 0.0068 0.1167 0.1167
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.002 0.002
Schistosoma mansoni tar DNA-binding protein 0.0187 0.359 0.359
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0119
Trichomonas vaginalis tubulin alpha chain, putative 0.0121 0.2247 0.5184
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0187 0.359 0.519
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0493 0.1141
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0011 0.002 0.0047
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.0011 0.0011
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0493 0.1141
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0016
Echinococcus multilocularis dro:myosuppressin receptor 0.0068 0.1167 0.1167
Schistosoma mansoni biogenic amine (5HT) receptor 0.0068 0.1167 0.1167
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0014 0.0014
Plasmodium vivax tubulin alpha chain, putative 0.0169 0.3218 0.7448
Schistosoma mansoni histamine h1 receptor 0.0068 0.1167 0.1167
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Echinococcus granulosus neuropeptide receptor A26 0.0068 0.1167 0.1167
Echinococcus granulosus cathepsin l1 0.0023 0.0258 0.0258
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0091 0.1649 0.1649
Leishmania major beta tubulin 0.0223 0.4321 1
Brugia malayi larval opioid receptor 0.0068 0.1167 0.1676
Echinococcus multilocularis tubulin alpha 1C chain 0.0169 0.3218 0.3218
Loa Loa (eye worm) doublecortin family protein 0.002 0.0195 0.0268
Toxoplasma gondii beta tubulin 0.0223 0.4321 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0014 0.0014
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0011 0.002 0.002
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0441 0.0441
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0258 0.0596
Loa Loa (eye worm) cysteine protease 0.0023 0.0258 0.036
Loa Loa (eye worm) thymidylate synthase 0.0195 0.374 0.5408
Echinococcus multilocularis serotonin receptor 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0116 0.2153 0.4967
Entamoeba histolytica tubulin family protein 0.0223 0.4321 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Brugia malayi hypothetical protein 0.0068 0.1167 0.1676
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0258 0.0596
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Trypanosoma brucei zeta tubulin 0.0053 0.0859 0.1989
Echinococcus multilocularis cathepsin L cysteine protease 0.0023 0.0258 0.0258
Entamoeba histolytica P-glycoprotein 5, putative 0.0011 0.0014 0.0033
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0011 0.002 0.0047
Trichomonas vaginalis tubulin, putative 0.0223 0.4321 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.018 0.0417
Brugia malayi putative neuropeptide receptor NPR1 0.0068 0.1167 0.1676
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.018 0.0417
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0068 0.1167 0.1167
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0258 0.0596
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0268 0.0717
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Schistosoma mansoni neuropeptide F-like receptor 0.0068 0.1167 0.1167
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.018 0.0385
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0014 0.0014
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0493 0.1141
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Echinococcus granulosus fmrfamide receptor 0.0068 0.1167 0.1167
Entamoeba histolytica P-glycoprotein-2 0.0011 0.0014 0.0033
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.018 0.018
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Plasmodium falciparum tubulin delta chain, putative 0.0053 0.0859 0.1989
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0091 0.1649 0.1649
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Echinococcus granulosus g protein coupled receptor 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Entamoeba histolytica hypothetical protein 0.0036 0.0525 0.1214
Echinococcus multilocularis tubulin alpha 3 chain 0.0169 0.3218 0.3218
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0493 0.1111
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0068 0.1167 0.1167
Schistosoma mansoni hypothetical protein 0.004 0.0608 0.0608
Trichomonas vaginalis tubulin beta chain, putative 0.0169 0.3218 0.7439
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.018 0.0417
Brugia malayi hypothetical protein 0.0068 0.1167 0.1676
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.1167 0.1167
Brugia malayi Tubulin alpha chain 0.0053 0.0859 0.123
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0441 0.0623
Echinococcus granulosus biogenic amine 5HT receptor 0.0068 0.1167 0.1167
Plasmodium falciparum phosphodiesterase gamma, putative 0.0011 0.002 0.0047
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0053 0.0859 0.1989
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis neuropeptide Y receptor 0.0068 0.1167 0.1167
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.008 0.1423 0.1423
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0023 0.0258 0.0258
Brugia malayi Latrophilin receptor protein 2 0.0031 0.043 0.0607
Echinococcus granulosus tubulin gamma 1 chain 0.0121 0.2247 0.2247
Brugia malayi TAR-binding protein 0.0187 0.359 0.5189
Schistosoma mansoni neuropeptide receptor 0.0068 0.1167 0.1167
Schistosoma mansoni tubulin subunit beta 0.0223 0.4321 0.4321
Leishmania major gamma-tubulin 0.0121 0.2247 0.52
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0279 0.0279
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Echinococcus granulosus peroxisome assembly protein 26 0.0169 0.3218 0.3218
Echinococcus multilocularis tubulin subunit TubB 0.0169 0.3218 0.3218
Trypanosoma brucei epsilon tubulin 0.0121 0.2247 0.52
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0011 0.002 0.002
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0268 0.0717
Schistosoma mansoni tubulin subunit beta 0.0223 0.4321 0.4321
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0023 0.0258 0.0258
Leishmania major beta tubulin 0.0223 0.4321 1
Loa Loa (eye worm) neuropeptide F receptor 0.0068 0.1167 0.1678
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0068 0.1167 0.1676
Onchocerca volvulus 0.0068 0.1167 0.31
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.018 0.0417
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0441 0.0441
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.018 0.0417
Plasmodium vivax vivapain-2 0.0023 0.0258 0.0596
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0441 0.1021
Leishmania major beta tubulin 0.0223 0.4321 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0169 0.3218 0.3218
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.2188 0.2188
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0011 0.002 0.0047
Brugia malayi hypothetical protein 0.0151 0.2861 0.4132
Trypanosoma brucei alpha tubulin 0.0169 0.3218 0.7448
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0002
Brugia malayi AKH receptor 0.0068 0.1167 0.1676
Loa Loa (eye worm) tubulin alpha 2 0.0116 0.2153 0.3108
Entamoeba histolytica hypothetical protein 0.0036 0.0525 0.1214
Trichomonas vaginalis tubulin epsilon chain, putative 0.0169 0.3218 0.7439
Schistosoma mansoni alpha tubulin 0.0169 0.3218 0.3218
Echinococcus granulosus dro:myosuppressin receptor 0.0068 0.1167 0.1167
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0011 0.002 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0258 0.0565
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.3458 0.9243
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0708 0.1013
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0011 0.002 0.0047
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0014 0.0014
Brugia malayi isocitrate dehydrogenase 0.0032 0.0441 0.0623
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0068 0.1167 0.31
Echinococcus multilocularis fmrfamide receptor 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1677
Echinococcus granulosus neuropeptide Y receptor 0.0068 0.1167 0.1167
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0441 0.1021
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0068 0.1167 0.1167
Brugia malayi hypothetical protein 0.0068 0.1167 0.1676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Trichomonas vaginalis tubulin beta chain, putative 0.0169 0.3218 0.7439
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0047
Loa Loa (eye worm) tubulin gamma chain 0.0121 0.2247 0.3243
Entamoeba histolytica hypothetical protein 0.0036 0.0525 0.1214
Brugia malayi hypothetical protein 0.0036 0.0525 0.0744
Loa Loa (eye worm) hypothetical protein 0.0031 0.043 0.0609
Onchocerca volvulus 0.0068 0.1167 0.31
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.1761 0.2537
Schistosoma mansoni opsin-like receptor 0.0068 0.1167 0.1167
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0268 0.0621
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.043 0.0607
Loa Loa (eye worm) PDE1B protein 0.0011 0.002 0.0016
Trichomonas vaginalis tubulin epsilon chain, putative 0.0223 0.4321 1
Plasmodium vivax vivapain-2 0.0023 0.0258 0.0596
Onchocerca volvulus 0.0068 0.1167 0.31
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Echinococcus multilocularis Tubulin beta 2C chain 0.0223 0.4321 0.4321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Entamoeba histolytica tubulin alpha chain, putative 0.0169 0.3218 0.7448
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Onchocerca volvulus 0.0151 0.2861 0.7642
Echinococcus multilocularis tubulin alpha chain 0.0169 0.3218 0.3218
Leishmania major beta tubulin 0.0223 0.4321 1
Toxoplasma gondii beta-tubulin, putative 0.0223 0.4321 1
Echinococcus granulosus tubulin beta 4A class IVa 0.0223 0.4321 0.4321
Trichomonas vaginalis tubulin alpha chain, putative 0.0223 0.4321 1
Echinococcus granulosus neuropeptides capa receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0011 0.002 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Loa Loa (eye worm) hypothetical protein 0.0023 0.0258 0.036
Echinococcus granulosus tubulin alpha 3 chain 0.0169 0.3218 0.3218
Onchocerca volvulus 0.0023 0.0258 0.0661
Toxoplasma gondii alpha tubulin TUBA1 0.0169 0.3218 0.7448
Trypanosoma brucei unspecified product 0.0013 0.006 0.014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0441 0.0441
Echinococcus multilocularis g-protein coupled receptor 0.0068 0.1167 0.1167
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0091 0.1649 0.3787
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0011 0.002 0.0047
Onchocerca volvulus 0.0023 0.0258 0.0661
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.018 0.0445
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0068 0.1167 0.1676
Loa Loa (eye worm) hypothetical protein 0.0097 0.1761 0.2538
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0011 0.0014 0.0033
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0258 0.0596
Onchocerca volvulus 0.0023 0.0258 0.0661
Echinococcus multilocularis Tubulin beta 2C chain 0.0223 0.4321 0.4321
Onchocerca volvulus 0.0068 0.1167 0.31
Schistosoma mansoni neuropeptide f receptor 76f 0.0068 0.1167 0.1167
Onchocerca volvulus 0.0068 0.1167 0.31
Brugia malayi N-terminal motif family protein 0.0181 0.3458 0.4997
Schistosoma mansoni hypothetical protein 0.0068 0.1167 0.1167
Schistosoma mansoni alpha tubulin 0.0169 0.3218 0.3218
Loa Loa (eye worm) tubulin beta-1 chain 0.0223 0.4321 0.625
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Brugia malayi RNA binding protein 0.0187 0.359 0.5189
Echinococcus granulosus peptide allatostatin:somatostatin 0.0068 0.1167 0.1167
Echinococcus granulosus somatostatin receptor 0.0068 0.1167 0.1167
Echinococcus granulosus orexin receptor type 2 0.0068 0.1167 0.1167
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.002 0.0014
Trichomonas vaginalis tubulin alpha chain, putative 0.0068 0.1182 0.2712
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0258 0.0357
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0011 0.002 0.0014
Trypanosoma brucei epsilon tubulin 0.0121 0.2247 0.52
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Schistosoma mansoni opsin-like receptor 0.0068 0.1167 0.1167
Brugia malayi hypothetical protein 0.0068 0.1167 0.1676
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.1167 0.1167
Schistosoma mansoni neuropeptide F-like receptor 0.0068 0.1167 0.1167
Echinococcus granulosus 7TM GPCR rhodopsin 0.0068 0.1167 0.1167
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Schistosoma mansoni adenoreceptor 0.0068 0.1167 0.1167
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Schistosoma mansoni tubulin subunit alpha 0.0169 0.3218 0.3218
Echinococcus multilocularis tubulin delta chain 0.0053 0.0859 0.0859
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.018 0.0247
Echinococcus multilocularis neuropeptide receptor A26 0.0068 0.1167 0.1167
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0011 0.0014 0.0007
Plasmodium falciparum alpha tubulin 2 0.0169 0.3218 0.7448
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0119
Echinococcus multilocularis neuropeptides capa receptor 0.0068 0.1167 0.1167
Schistosoma mansoni alpha-1 adrenergic receptor 0.0068 0.1167 0.1167
Leishmania major beta tubulin 0.0223 0.4321 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0268 0.0375
Echinococcus granulosus neuropeptide FF receptor 2 0.0068 0.1167 0.1167
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.01 0.1831 0.4217
Trypanosoma brucei alpha tubulin 0.0169 0.3218 0.7448
Giardia lamblia Alpha-tubulin 0.0169 0.3218 0.7435
Trypanosoma brucei tubulin delta chain 0.0053 0.0859 0.1989
Echinococcus granulosus sex peptide receptor 0.0068 0.1167 0.1167
Loa Loa (eye worm) beta-tubulin 0.0223 0.4321 0.625
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0068 0.1167 0.1678
Onchocerca volvulus 0.0068 0.1182 0.314
Toxoplasma gondii alpha-tubulin I, putative 0.0169 0.3218 0.7448
Schistosoma mansoni hypothetical protein 0.0068 0.1167 0.1167
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0068 0.1167 0.1167
Brugia malayi Cathepsin L-like precursor 0.0023 0.0258 0.0357
Loa Loa (eye worm) melatonin receptor type 1A 0.0068 0.1167 0.1678
Echinococcus multilocularis Tubulin beta 2C chain 0.0223 0.4321 0.4321
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0279 0.0279
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0268 0.0681
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.006 0.014
Leishmania major beta tubulin 0.0223 0.4321 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.043 0.043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0258 0.0596
Trichomonas vaginalis tubulin beta chain, putative 0.0169 0.3218 0.7439
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.018 0.0417
Trypanosoma cruzi tubulin delta chain 0.0053 0.0859 0.1989
Mycobacterium tuberculosis Hypothetical protein 0.0093 0.1672 0.4448
Schistosoma mansoni smad1 5 8 and 0.0024 0.0279 0.0279
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0258 0.0565
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0195 0.0451
Schistosoma mansoni amine GPCR 0.0068 0.1167 0.1167
Giardia lamblia Beta tubulin 0.0223 0.4321 1
Echinococcus multilocularis sex peptide receptor 0.0068 0.1167 0.1167
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0708 0.0708
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0023 0.0258 0.0258
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.008 0.1423 0.1423
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0148 0.0397
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0441 0.1021
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0047
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0011 0.002 0.0047
Loa Loa (eye worm) TAR-binding protein 0.0187 0.359 0.519
Echinococcus granulosus RUN 0.002 0.0195 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Entamoeba histolytica hypothetical protein 0.0036 0.0525 0.1214
Leishmania major p-glycoprotein 0.0011 0.0014 0.0033
Mycobacterium ulcerans thymidylate synthase 0.0195 0.374 1
Echinococcus multilocularis orexin receptor type 2 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0017 0.0148 0.0201
Leishmania major beta tubulin 0.0223 0.4321 1
Onchocerca volvulus 0.0068 0.1167 0.31
Loa Loa (eye worm) hypothetical protein 0.0042 0.0638 0.0911
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0195 0.0195
Schistosoma mansoni smad1 5 8 and 0.0024 0.0279 0.0279
Trypanosoma brucei tubulin gamma chain 0.0121 0.2247 0.52
Loa Loa (eye worm) hypothetical protein 0.002 0.0195 0.0268
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0121 0.2247 0.52
Trichomonas vaginalis tubulin, putative 0.0068 0.1182 0.2712
Brugia malayi hypothetical protein 0.0068 0.1167 0.1676
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0258 0.0258
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0011 0.002 0.002
Brugia malayi RE15519p 0.0068 0.1167 0.1676
Trichomonas vaginalis tubulin, putative 0.0053 0.0859 0.1962
Echinococcus multilocularis Tubulin alpha 1 chain 0.0169 0.3218 0.3218
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0047
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.018 0.0417
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.2604 0.2604
Trypanosoma brucei beta tubulin 0.0121 0.2247 0.52
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0195 0.0195
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0258 0.0565
Loa Loa (eye worm) Smad1 0.0024 0.0279 0.0391
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Brugia malayi MH2 domain containing protein 0.0351 0.6908 1
Trypanosoma brucei alpha tubulin, putative 0.0068 0.1182 0.2736
Echinococcus multilocularis hypothetical protein 0.0169 0.3218 0.3218
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0007
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0493 0.1141
Echinococcus multilocularis cysteine protease 0.0023 0.0258 0.0258
Schistosoma mansoni lipoxygenase 0.0083 0.1468 0.1468
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0279 0.0279
Toxoplasma gondii beta-1 tubulin, putative 0.0223 0.4321 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0221 0.4267 0.9875
Plasmodium falciparum phosphodiesterase delta, putative 0.0011 0.002 0.0047
Loa Loa (eye worm) hypothetical protein 0.0019 0.018 0.0247
Trypanosoma cruzi beta tubulin, putative 0.0223 0.4321 1
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0014 0.0014
Schistosoma mansoni DNA polymerase eta 0.0019 0.018 0.018
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0441 0.1021
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Trypanosoma brucei unspecified product 0.0013 0.006 0.014
Trypanosoma brucei beta tubulin 0.0223 0.4321 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0011 0.002 0.0047
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0068 0.1167 0.1167
Brugia malayi beta-NAC-like protein 0.0034 0.0493 0.0698
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Brugia malayi Cathepsin L-like precursor 0.0023 0.0258 0.0357
Leishmania major DNA polymerase kappa, putative 0.0019 0.018 0.0417
Plasmodium falciparum cysteine proteinase falcipain 3 0.0023 0.0258 0.0596
Echinococcus multilocularis tubulin alpha chain 0.0169 0.3218 0.3218
Echinococcus multilocularis thymidylate synthase 0.0195 0.374 0.374
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.1167 0.1167
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0268 0.0372
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1802 0.2596
Echinococcus granulosus Tubulin beta 2C chain 0.0223 0.4321 0.4321
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Trichomonas vaginalis tubulin gamma chain, putative 0.0121 0.2247 0.5184
Echinococcus multilocularis g protein coupled receptor 0.0068 0.1167 0.1167
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0195 0.0195
Echinococcus granulosus tubulin alpha chain 0.0169 0.3218 0.3218
Trypanosoma cruzi zeta tubulin, putative 0.0053 0.0859 0.1989
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Echinococcus multilocularis tubulin subunit beta 0.0223 0.4321 0.4321
Trichomonas vaginalis tubulin epsilon chain, putative 0.0169 0.3218 0.7439
Schistosoma mansoni hypothetical protein 0.0503 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Echinococcus granulosus cathepsin L cysteine protease 0.0023 0.0258 0.0258
Brugia malayi Cathepsin L-like precursor 0.0015 0.0092 0.0117
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0195 0.374 0.8655
Brugia malayi G protein-coupled receptor F59B2.13 0.0068 0.1167 0.1676
Trichomonas vaginalis tubulin alpha chain, putative 0.0068 0.1182 0.2712
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0047
Schistosoma mansoni Smad4 0.0024 0.0279 0.0279
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.0258 0.0565
Loa Loa (eye worm) MH2 domain-containing protein 0.0351 0.6908 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Trichomonas vaginalis tubulin beta chain, putative 0.0169 0.3218 0.7439
Loa Loa (eye worm) transcription factor SMAD2 0.0351 0.6908 1
Schistosoma mansoni smad 0.0024 0.0279 0.0279
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0047
Schistosoma mansoni polycystin 1-related 0.002 0.0195 0.0195
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Echinococcus granulosus neuropeptides capa receptor 0.0068 0.1167 0.1167
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0011 0.002 0.0047
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0068 0.1167 0.1167
Echinococcus granulosus Tubulin alpha 1 chain 0.0169 0.3218 0.3218
Trypanosoma brucei beta tubulin 0.0223 0.4321 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0223 0.4321 0.4321
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0268 0.0621
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0129 0.0308
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0195 0.0195
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.0011 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Brugia malayi beta-tubulin, identical 0.0223 0.4321 0.6249
Leishmania major basic transcription factor 3a, putative 0.0034 0.0493 0.1141
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0011 0.002 0.002
Trichomonas vaginalis tubulin beta chain, putative 0.0068 0.1182 0.2712
Leishmania major beta tubulin 0.0223 0.4321 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0011 0.001 0.001
Echinococcus granulosus tubulin alpha chain 0.0169 0.3218 0.3218
Schistosoma mansoni tar DNA-binding protein 0.0187 0.359 0.359
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1167 0.1167
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Trypanosoma brucei unspecified product 0.0019 0.018 0.0417
Trypanosoma cruzi tubulin gamma chain 0.0121 0.2247 0.52
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0011 0.002 0.0016
Brugia malayi hypothetical protein 0.0068 0.1167 0.1676
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0493 0.1141
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0068 0.1167 0.1167
Schistosoma mansoni neuropeptide receptor 0.0068 0.1167 0.1167
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Leishmania major cathepsin L-like protease 0.0023 0.0258 0.0596
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0017 0.0148 0.0201
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0279 0.0391
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0268 0.0621
Brugia malayi hypothetical protein 0.002 0.0195 0.0266
Plasmodium vivax phosphodiesterase gamma, putative 0.0011 0.002 0.0047
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0016
Echinococcus granulosus transcription factor btf3 0.0034 0.0493 0.0493
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0068 0.1167 0.1167
Echinococcus granulosus tubulin delta chain 0.0053 0.0859 0.0859
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0011 0.002 0.002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus granulosus tachykinin peptides receptor 99D 0.0068 0.1167 0.1167
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.018 0.0417
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0011 0.002 0.0047
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0181 0.3458 0.4999
Trypanosoma cruzi zeta tubulin, putative 0.0053 0.0859 0.1989
Brugia malayi CHE-14 protein 0.0042 0.0638 0.0909
Echinococcus granulosus alpha tubulin 0.0169 0.3218 0.3218
Trypanosoma brucei alpha tubulin 0.0169 0.3218 0.7448
Echinococcus multilocularis neuropeptides capa receptor 0.0068 0.1167 0.1167
Leishmania major cAMP-specific phosphodiesterase, putative 0.0011 0.002 0.0047
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Echinococcus multilocularis Tubulin alpha 1 chain 0.0169 0.3218 0.3218
Plasmodium vivax unspecified product 0.0015 0.0092 0.0213
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0068 0.1167 0.1167
Brugia malayi hypothetical protein 0.0068 0.1167 0.1676
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0195 0.0195
Brugia malayi putative neuropeptide receptor 0.0068 0.1167 0.1676
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0268 0.0681
Echinococcus granulosus tubulin epsilon chain 0.0121 0.2247 0.2247
Leishmania major cathepsin L-like protease 0.0023 0.0258 0.0596
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0195 0.374 0.8655
Schistosoma mansoni hypothetical protein 0.0031 0.043 0.043
Echinococcus granulosus neuropeptide Y receptor 0.0068 0.1167 0.1167
Echinococcus granulosus cathepsin L cysteine proteinase 0.0023 0.0258 0.0258
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0023 0.0258 0.0258
Schistosoma mansoni loxhd1 0.002 0.0195 0.0195
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0068 0.1167 0.1167
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0047
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Trichomonas vaginalis tubulin beta chain, putative 0.0169 0.3218 0.7439
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0268 0.0717
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0441 0.0441
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Echinococcus multilocularis G-protein coupled receptor, putative 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Brugia malayi Tubulin beta chain 0.0068 0.1182 0.1698
Echinococcus multilocularis tubulin epsilon chain 0.0121 0.2247 0.2247
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Echinococcus multilocularis protein dispatched 1 0.0048 0.0758 0.0758
Brugia malayi hypothetical protein 0.0093 0.1672 0.2407
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0011 0.002 0.0047
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0011 0.002 0.002
Brugia malayi G-protein coupled receptor 0.0068 0.1167 0.1676
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0268 0.0717
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0708 0.0708
Schistosoma mansoni tubulin subunit beta 0.0223 0.4321 0.4321
Onchocerca volvulus 0.0023 0.0258 0.0661
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Brugia malayi Tubulin alpha-2 chain 0.0169 0.3218 0.465
Entamoeba histolytica tubulin alpha-1 chain 0.0169 0.3218 0.7448
Echinococcus granulosus tubulin beta 1 chain 0.0223 0.4321 0.4321
Brugia malayi GnHR receptor homolog 0.0068 0.1167 0.1676
Loa Loa (eye worm) neuropeptide F receptor 0.0068 0.1167 0.1678
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0023 0.0258 0.036
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Loa Loa (eye worm) hypothetical protein 0.0099 0.1802 0.2598
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0011 0.002 0.0014
Trypanosoma brucei hypothetical protein, conserved 0.0011 0.002 0.0047
Entamoeba histolytica tubulin family protein 0.0223 0.4321 1
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.1167 0.1167
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Onchocerca volvulus 0.0068 0.1167 0.31
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.043 0.0609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Loa Loa (eye worm) multidrug resistance protein 3 0.0011 0.0014 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0268 0.0717
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0023 0.0258 0.036
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Trypanosoma cruzi cruzipain precursor, putative 0.0023 0.0258 0.0596
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0053 0.0859 0.1989
Entamoeba histolytica P-glyco protein 6, putative 0.0011 0.0014 0.0033
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0011 0.002 0.002
Loa Loa (eye worm) BEN-1 protein 0.0223 0.4321 0.625
Loa Loa (eye worm) tubulin beta chain 0.0053 0.0859 0.1232
Brugia malayi Cell division protein ftsZ 0.0053 0.0859 0.123
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0195 0.374 0.8655
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Giardia lamblia Epsilon tubulin 0.0053 0.0859 0.1951
Loa Loa (eye worm) hypothetical protein 0.01 0.1831 0.264
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0011 0.002 0.002
Echinococcus multilocularis protein patched 0.0042 0.0638 0.0638
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0258 0.0565
Leishmania major beta tubulin 0.0223 0.4321 1
Leishmania major cathepsin L-like protease 0.0023 0.0258 0.0596
Leishmania major cathepsin L-like protease 0.0023 0.0258 0.0596
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Trypanosoma cruzi tubulin delta chain 0.0053 0.0859 0.1989
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.006 0.014
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0011 0.002 0.002
Onchocerca volvulus 0.0195 0.374 1
Schistosoma mansoni tubulin subunit beta 0.0053 0.0859 0.0859
Schistosoma mansoni amine GPCR 0.0068 0.1167 0.1167
Mycobacterium ulcerans cell division protein FtsZ 0.0053 0.0859 0.2298
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0258 0.0596
Loa Loa (eye worm) TYRA-2 protein 0.0068 0.1167 0.1678
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.1167 0.1167
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0441 0.0441
Echinococcus granulosus Tubulin alpha 1 chain 0.0169 0.3218 0.3218
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1167 0.1167
Leishmania major cysteine peptidase A (CPA) 0.0023 0.0258 0.0596
Brugia malayi ORL1-like opioid receptor 0.0068 0.1167 0.1676
Schistosoma mansoni neuropeptide receptor 0.0068 0.1167 0.1167
Schistosoma mansoni tubulin subunit alpha 0.0169 0.3218 0.3218
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0068 0.1167 0.1167
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Echinococcus multilocularis multidrug resistance protein 1 0.0011 0.0014 0.0014
Trichomonas vaginalis tubulin epsilon chain, putative 0.0053 0.0859 0.1962
Brugia malayi MH2 domain containing protein 0.0024 0.0279 0.0389
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0441 0.1021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Brugia malayi tubulin alpha chain - mouse 0.0169 0.3218 0.465
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.018 0.0417
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.002 0.0013
Onchocerca volvulus 0.0068 0.1167 0.31
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Brugia malayi MH1 domain containing protein 0.0024 0.0279 0.0389
Brugia malayi alpha-tubulin 0.0169 0.3218 0.465
Trypanosoma cruzi cysteine proteinase, putative 0.0023 0.0258 0.0596
Echinococcus multilocularis neuropeptide receptor 0.0068 0.1167 0.1167
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0638 0.0638
Leishmania major cathepsin L-like protease 0.0023 0.0258 0.0596
Entamoeba histolytica hypothetical protein 0.0034 0.0493 0.1141
Schistosoma mansoni cathepsin s 0.0015 0.0092 0.0092
Echinococcus granulosus allatostatin A receptor 0.0068 0.1167 0.1167
Leishmania major beta tubulin 0.0223 0.4321 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Loa Loa (eye worm) alpha-tubulin 0.0169 0.3218 0.4651
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0129 0.0308
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.1761 0.1761
Brugia malayi MH2 domain containing protein 0.0024 0.0279 0.0389
Schistosoma mansoni tubulin subunit gamma 0.0121 0.2247 0.2247
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Leishmania major beta tubulin 0.0223 0.4321 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0279 0.0279
Trichomonas vaginalis tubulin, putative 0.0068 0.1182 0.2712
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Echinococcus multilocularis tar DNA binding protein 0.0187 0.359 0.359
Schistosoma mansoni biogenic amine receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0525 0.0525
Trichomonas vaginalis tubulin gamma chain, putative 0.0223 0.4321 1
Brugia malayi hypothetical protein 0.0068 0.1167 0.1676
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0195 0.374 0.8655
Schistosoma mansoni lipoxygenase 0.0118 0.2188 0.2188
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.018 0.0417
Brugia malayi Serotonin receptor 0.0068 0.1167 0.1676
Echinococcus multilocularis Tubulin beta 2C chain 0.0223 0.4321 0.4321
Echinococcus multilocularis G protein coupled receptor 139 0.0068 0.1167 0.1167
Brugia malayi MH1 domain containing protein 0.0013 0.0063 0.0075
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0068 0.1167 0.1167
Brugia malayi Dopamine receptor protein 1 0.0068 0.1167 0.1676
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Onchocerca volvulus 0.002 0.0195 0.0492
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.1761 0.1761
Echinococcus granulosus thymidylate synthase 0.0195 0.374 0.374
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.1167 0.1167
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0047
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0047
Schistosoma mansoni tubulin subunit beta 0.0223 0.4321 0.4321
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Leishmania major cathepsin L-like protease 0.0023 0.0258 0.0596
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Echinococcus multilocularis dna polymerase eta 0.0019 0.018 0.018
Echinococcus granulosus beta tubulin 0.0223 0.4321 0.4321
Echinococcus granulosus tubulin alpha chain 0.0169 0.3218 0.3218
Loa Loa (eye worm) hypothetical protein 0.0017 0.0148 0.0201
Brugia malayi RNA recognition motif domain containing protein 0.0187 0.359 0.5189
Echinococcus granulosus hypothetical protein 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Trypanosoma brucei zeta tubulin, putative 0.0053 0.0859 0.1989
Trypanosoma cruzi cruzipain precursor, putative 0.0015 0.0092 0.0213
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Schistosoma mansoni hypothetical protein 0.002 0.0195 0.0195
Leishmania major beta tubulin 0.0223 0.4321 1
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Echinococcus multilocularis multidrug resistance protein 1 0.0011 0.0014 0.0014
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0195 0.374 0.8655
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0258 0.0596
Plasmodium vivax tubulin gamma chain, putative 0.0121 0.2247 0.52
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.002 0.0014
Schistosoma mansoni tubulin subunit alpha 0.0053 0.0859 0.0859
Echinococcus multilocularis ATP binding cassette sub family B 0.0011 0.001 0.001
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0068 0.1167 0.1676
Giardia lamblia Beta tubulin 0.0223 0.4321 1
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0053 0.0859 0.1962
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Schistosoma mansoni hypothetical protein 0.0068 0.1167 0.1167
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0441 0.0625
Echinococcus multilocularis tubulin alpha chain 0.0169 0.3218 0.3218
Brugia malayi neuropeptide F receptor 0.0068 0.1167 0.1676
Schistosoma mansoni growth hormone secretagogue receptor 0.0068 0.1167 0.1167
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0011 0.002 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1167 0.1167
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0268 0.0372
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1167 0.1167
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.002 0.002
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0011 0.002 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1167 0.1167
Plasmodium falciparum tubulin beta chain 0.0223 0.4321 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0068 0.1167 0.1676
Brugia malayi Melatonin receptor type 1A 0.0068 0.1167 0.1676
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.018 0.0385
Echinococcus multilocularis cathepsin L 0.0023 0.0258 0.0258
Leishmania major beta tubulin 0.0223 0.4321 1
Loa Loa (eye worm) tubulin alpha 2 0.0048 0.0766 0.1096
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0015 0.0092 0.0117
Leishmania major hypothetical protein, conserved 0.0011 0.002 0.0047
Schistosoma mansoni smad1 5 8 and 0.0024 0.0279 0.0279
Brugia malayi G-protein coupled receptor 0.0068 0.1167 0.1676
Plasmodium vivax unspecified product 0.0221 0.4267 0.9875
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0068 0.1167 0.1167
Schistosoma mansoni transcription factor btf3 0.0034 0.0493 0.0493
Echinococcus granulosus expressed conserved protein 0.0091 0.1642 0.1642
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.1167 0.1167
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0013 0.0063 0.0077
Echinococcus granulosus tubulin alpha 1C chain 0.0169 0.3218 0.3218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.2604 0.2604
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0148 1
Onchocerca volvulus 0.002 0.0195 0.0492
Schistosoma mansoni amine GPCR 0.0068 0.1167 0.1167
Loa Loa (eye worm) G-protein coupled receptor 0.0068 0.1167 0.1678
Schistosoma mansoni tar DNA-binding protein 0.0187 0.359 0.359
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0011 0.002 0.0013
Schistosoma mansoni hypothetical protein 0.0068 0.1167 0.1167
Echinococcus multilocularis dna polymerase kappa 0.0019 0.018 0.018
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.1167 0.1675
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0093 0.1672 0.3868
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.1167 0.1167
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0195 0.0451
Treponema pallidum cell division protein FtsZ 0.0053 0.0859 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.002 0.0195 0.0268
Loa Loa (eye worm) tubulin alpha-3 chain 0.01 0.1831 0.264
Brugia malayi Tubulin beta-1 chain 0.0223 0.4321 0.6249
Echinococcus multilocularis peroxisome assembly protein 26 0.0169 0.3218 0.3218
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus granulosus tubulin alpha chain 0.0169 0.3218 0.3218
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Loa Loa (eye worm) alpha-tubulin 0.0169 0.3218 0.4651
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0091 0.1649 0.2376
Echinococcus granulosus cathepsin L 0.0023 0.0258 0.0258
Echinococcus multilocularis beta tubulin 0.0223 0.4321 0.4321
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0493 0.1111
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0011 0.002 0.0047
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0011 0.002 0.0047
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0258 0.0565
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.043 0.043
Mycobacterium leprae cell division protein FtsZ 0.0053 0.0859 0.1703
Schistosoma mansoni multidrug resistance protein 0.0011 0.0014 0.0014
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0195 0.374 1
Brugia malayi MH1 domain containing protein 0.0024 0.0279 0.0389
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.002 0.0047
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0068 0.1167 0.1676
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.1791 0.1791
Echinococcus granulosus G protein coupled receptor 139 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Entamoeba histolytica tubulin gamma chain 0.0121 0.2247 0.52
Giardia lamblia Alpha-tubulin 0.0169 0.3218 0.7435
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0258 0.0596
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0493 0.1141
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.0011 0.0002
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0091 0.1649 0.3816
Loa Loa (eye worm) tubulin beta-2A chain 0.0223 0.4321 0.625
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0441 0.1021
Echinococcus multilocularis tubulin alpha chain 0.0169 0.3218 0.3218
Plasmodium falciparum tubulin epsilon chain, putative 0.0121 0.2247 0.52
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0023 0.0258 0.0596
Brugia malayi cathepsin F-like cysteine proteinase 0.0015 0.0092 0.0117
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0068 0.1167 0.1167
Plasmodium falciparum tubulin gamma chain 0.0121 0.2247 0.52
Onchocerca volvulus 0.0023 0.0258 0.0661
Loa Loa (eye worm) BEN-1 protein 0.0223 0.4321 0.625
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0007
Echinococcus multilocularis tubulin alpha 1C chain 0.0169 0.3218 0.3218
Echinococcus multilocularis geminin 0.0503 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.006 0.014
Entamoeba histolytica cysteine proteinase 2 0.0023 0.0258 0.0596
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Echinococcus granulosus dna polymerase eta 0.0019 0.018 0.018
Echinococcus multilocularis fmrfamide receptor 0.0068 0.1167 0.1167
Echinococcus granulosus g-protein coupled receptor 0.0068 0.1167 0.1167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Echinococcus multilocularis tubulin beta 1 chain 0.0223 0.4321 0.4321
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0091 0.1649 0.1649
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.1167 0.1167
Leishmania major hypothetical protein, conserved 0.0011 0.002 0.0047
Loa Loa (eye worm) ctsf protein 0.0023 0.0258 0.036
Echinococcus granulosus GPCR family 2 0.0031 0.043 0.043
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0011 0.002 0.002
Echinococcus multilocularis beta tubulin 0.0223 0.4321 0.4321
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0258 0.0357
Onchocerca volvulus 0.0068 0.1167 0.31
Echinococcus granulosus tubulin alpha 1C chain 0.0169 0.3218 0.3218
Loa Loa (eye worm) hypothetical protein 0.0017 0.0148 0.0201
Trypanosoma cruzi alpha tubulin, putative 0.0169 0.3218 0.7448
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0195 0.374 0.8655
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.018 0.0417
Leishmania major delta tubulin, putative 0.0053 0.0859 0.1989
Loa Loa (eye worm) hypothetical protein 0.0051 0.0828 0.1187
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.018 0.0245
Echinococcus multilocularis transcription factor btf3 0.0034 0.0493 0.0493
Echinococcus granulosus Tubulin beta 2C chain 0.0223 0.4321 0.4321
Plasmodium falciparum alpha tubulin 1 0.0169 0.3218 0.7448
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0068 0.1167 0.1167
Brugia malayi thymidylate synthase 0.0195 0.374 0.5407
Trichomonas vaginalis tubulin beta chain, putative 0.0169 0.3218 0.7439
Onchocerca volvulus 0.0068 0.1167 0.31
Loa Loa (eye worm) tubulin alpha chain 0.0169 0.3218 0.4651
Schistosoma mansoni hypothetical protein 0.0036 0.0525 0.0525
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0638 0.0911
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0011 0.002 0.002
Echinococcus multilocularis Smad4 0.0024 0.0279 0.0279
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0258 0.0565
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0016
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0014 0.0014
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0279 0.0391
Schistosoma mansoni hypothetical protein 0.0031 0.043 0.043
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0638 0.1449
Echinococcus granulosus serotonin receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0119
Schistosoma mansoni amine GPCR 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Brugia malayi Tubulin alpha-2 chain 0.0169 0.3218 0.465
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.002 0.0014
Entamoeba histolytica P-glycoprotein-2 0.0011 0.0014 0.0033
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.002 0.002
Plasmodium vivax tubulin epsilon chain, putative 0.0121 0.2247 0.52
Loa Loa (eye worm) tubulin alpha chain 0.0169 0.3218 0.4651
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0011 0.0014 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.018 0.0417
Trichomonas vaginalis tubulin gamma chain, putative 0.0053 0.0859 0.1962
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.0011 0.0011
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0047
Schistosoma mansoni tubulin subunit beta 0.0223 0.4321 0.4321
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.018 0.0482
Echinococcus multilocularis neuropeptide FF receptor 2 0.0068 0.1167 0.1167
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0195 0.0195
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0195 0.374 0.374
Schistosoma mansoni tar DNA-binding protein 0.0187 0.359 0.359
Plasmodium vivax unspecified product 0.0206 0.397 0.9187
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Loa Loa (eye worm) hypothetical protein 0.0023 0.0268 0.0375
Brugia malayi Cathepsin L-like precursor 0.0023 0.0258 0.0357
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.008 0.1423 0.2047
Schistosoma mansoni rab6-interacting 0.002 0.0195 0.0195
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.018 0.0417
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0859 0.1962
Brugia malayi Tubulin gamma chain 0.0121 0.2247 0.3242
Echinococcus granulosus tubulin subunit TubB 0.0169 0.3218 0.3218
Loa Loa (eye worm) tubulin alpha-2 chain 0.0169 0.3218 0.4651
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0091 0.1649 0.1649
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0268 0.0717
Schistosoma mansoni amine GPCR 0.0068 0.1167 0.1167
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0708 0.0708
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Trypanosoma cruzi epsilon tubulin, putative 0.0121 0.2247 0.52
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.018 0.0417
Giardia lamblia Gamma tubulin 0.0121 0.2247 0.5177
Trichomonas vaginalis tubulin gamma chain, putative 0.0121 0.2247 0.5184
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0015 0.0092 0.0119
Echinococcus multilocularis expressed conserved protein 0.0091 0.1642 0.1642
Loa Loa (eye worm) tubulin beta chain 0.0223 0.4321 0.625
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0148 0.0344
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0441 0.1021
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.018 0.0417
Onchocerca volvulus Cathepsin F homolog 0.0023 0.0258 0.0661
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0708 0.0708
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0014 0.0014
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0068 0.1167 0.1167
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.018 0.018
Echinococcus granulosus tubulin alpha 0.0121 0.2247 0.2247
Echinococcus granulosus smad 0.0024 0.0279 0.0279
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0053 0.0859 0.5
Echinococcus granulosus tubulin subunit beta 0.0223 0.4321 0.4321
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.002 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Giardia lamblia DINP protein human, muc B family 0.0019 0.018 0.0371
Echinococcus multilocularis Tubulin beta 2C chain 0.0223 0.4321 0.4321
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0708 0.0708
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Schistosoma mansoni tubulin subunit epsilon 0.0121 0.2247 0.2247
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0258 0.0596
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0068 0.1167 0.1167
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0493 0.07
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0068 0.1167 0.1678
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1167 0.1167
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0195 0.374 1
Echinococcus granulosus tubulin alpha chain 0.0169 0.3218 0.3218
Echinococcus multilocularis allatostatin A receptor 0.0068 0.1167 0.1167
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0068 0.1167 0.1678
Echinococcus multilocularis Tubulin alpha 1 chain 0.0169 0.3218 0.3218
Schistosoma mansoni opsin-like receptor 0.0068 0.1167 0.1167
Toxoplasma gondii cathepsin CPL 0.0023 0.0258 0.0596
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0047
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0441 0.0441
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Schistosoma mansoni hypothetical protein 0.004 0.0608 0.0608
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0268 0.0372
Echinococcus multilocularis GPCR, family 2 0.0031 0.043 0.043
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.0011 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.018 0.0417
Brugia malayi Tubulin alpha chain 0.0169 0.3218 0.465
Schistosoma mansoni neuropeptide receptor 0.0068 0.1167 0.1167
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0258 0.0258
Schistosoma mansoni tubulin subunit beta 0.0223 0.4321 0.4321
Schistosoma mansoni Smad4 0.0011 0.0011 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0268 0.0717
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0068 0.1167 0.1167
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0258 0.0565
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0129 0.0308
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.018 0.0482
Echinococcus granulosus Tubulin beta 2C chain 0.0223 0.4321 0.4321
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.018 0.0417
Echinococcus multilocularis tubulin gamma 1 chain 0.0121 0.2247 0.2247
Brugia malayi Smad1 0.0024 0.0279 0.0389
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus granulosus biogenic amine 5HT receptor 0.0068 0.1167 0.1167
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0023 0.0258 0.0596
Plasmodium vivax tubulin alpha chain, putative 0.0169 0.3218 0.7448
Echinococcus granulosus Tubulin beta 2C chain 0.0223 0.4321 0.4321
Loa Loa (eye worm) hypothetical protein 0.0017 0.0148 0.0201
Schistosoma mansoni myosin xvIII 0.0068 0.1167 0.1167
Echinococcus multilocularis neuropeptide Y receptor 0.0068 0.1167 0.1167
Schistosoma mansoni hypothetical protein 0.0068 0.1167 0.1167
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.018 0.0445
Onchocerca volvulus 0.0068 0.1167 0.31
Schistosoma mansoni hypothetical protein 0.004 0.0608 0.0608
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Leishmania major epsilon tubulin, putative 0.0121 0.2247 0.52
Echinococcus granulosus neuropeptide receptor 0.0068 0.1167 0.1167
Schistosoma mansoni tubulin subunit alpha 0.0169 0.3218 0.3218
Brugia malayi Cathepsin L-like precursor 0.0023 0.0258 0.0357
Entamoeba histolytica P-glycoprotein-1 0.0011 0.0014 0.0033
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Brugia malayi multidrug resistance protein 3 0.0011 0.0014 0.0004
Echinococcus granulosus beta tubulin 0.0223 0.4321 0.4321
Onchocerca volvulus Cathepsin L homolog 0.0023 0.0258 0.0661
Schistosoma mansoni hypothetical protein 0.0031 0.043 0.043
Brugia malayi hypothetical protein 0.0068 0.1167 0.1676
Trypanosoma brucei alpha tubulin 0.0169 0.3218 0.7448
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.0258 0.0565
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0011 0.002 0.0014
Echinococcus multilocularis neuropeptide receptor 0.0068 0.1167 0.1167
Echinococcus granulosus tar DNA binding protein 0.0187 0.359 0.359
Trypanosoma brucei beta tubulin 0.0223 0.4321 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Plasmodium vivax tubulin beta chain, putative 0.0223 0.4321 1
Schistosoma mansoni multidrug resistance protein 0.0011 0.0014 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0708 0.0708
Echinococcus granulosus neuropeptide receptor 0.0068 0.1167 0.1167
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0023 0.0258 0.0596
Leishmania major cathepsin L-like protease 0.0023 0.0258 0.0596
Trichomonas vaginalis tubulin alpha chain, putative 0.0068 0.1182 0.2712
Schistosoma mansoni hypothetical protein 0.0031 0.043 0.043
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.1761 0.4075
Schistosoma mansoni tar DNA-binding protein 0.0187 0.359 0.359
Onchocerca volvulus 0.0068 0.1167 0.31
Echinococcus granulosus neuropeptide s receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis serotonin receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.043 0.043
Mycobacterium ulcerans hypothetical protein 0.0023 0.0268 0.0717
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0258 0.0596
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Loa Loa (eye worm) hypothetical protein 0.0169 0.3218 0.4651
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0068 0.1167 0.1678
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0068 0.1167 0.1167
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0068 0.1167 0.1167
Schistosoma mansoni patched 1 0.0042 0.0638 0.0638
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0011 0.0014 0.0033
Trypanosoma cruzi cysteine proteinase, putative 0.0023 0.0258 0.0596
Brugia malayi follicle stimulating hormone receptor 0.0068 0.1167 0.1676
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0011 0.002 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.1167 0.1167
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.1167 0.1167
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0441 0.1021
Plasmodium vivax vivapain-3 0.0023 0.0258 0.0596
Brugia malayi hypothetical protein 0.002 0.0195 0.0266
Mycobacterium tuberculosis Cell division protein FtsZ 0.0053 0.0859 0.2268
Onchocerca volvulus 0.0023 0.0268 0.0689
Onchocerca volvulus Neuropeptide F receptor homolog 0.0068 0.1167 0.31
Loa Loa (eye worm) hypothetical protein 0.0116 0.2153 0.3108
Loa Loa (eye worm) hypothetical protein 0.0023 0.0268 0.0375
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Loa Loa (eye worm) tubulin beta-4 chain 0.0223 0.4321 0.625
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Giardia lamblia Beta tubulin 0.0223 0.4321 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0258 0.0565
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0169 0.3218 0.7439
Leishmania major zeta tubulin, putative 0.0053 0.0859 0.1989
Echinococcus granulosus 7tm_1 domain containing protein 0.0068 0.1167 0.1167
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0068 0.1167 0.1678
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565
Trichomonas vaginalis tubulin epsilon chain, putative 0.0223 0.4321 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1802 0.2596
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.002 0.0047
Loa Loa (eye worm) G-protein coupled receptor 0.0068 0.1167 0.1678
Leishmania major beta tubulin 0.0223 0.4321 1
Onchocerca volvulus 0.0068 0.1167 0.31
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.018 0.018
Schistosoma mansoni rab6-interacting 0.002 0.0195 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.018 0.0417
Leishmania major alpha tubulin 0.0169 0.3218 0.7448
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0258 0.0565
Echinococcus granulosus Smad4 0.0024 0.0279 0.0279
Echinococcus granulosus cathepsin l cysteine peptidase 0.0023 0.0258 0.0258
Loa Loa (eye worm) RNA binding protein 0.0187 0.359 0.519
Echinococcus granulosus cysteine protease 0.0023 0.0258 0.0258
Brugia malayi G protein-coupled receptor 0.0068 0.1167 0.1676
Entamoeba histolytica P-glycoprotein-5 0.0011 0.0014 0.0033
Brugia malayi neuropeptide F receptor 0.0068 0.1167 0.1676
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.002 0.002
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0441 0.1145
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Brugia malayi Dopamine receptor protein 2 0.0068 0.1167 0.1676
Echinococcus granulosus Tubulin beta 2C chain 0.0223 0.4321 0.4321
Trypanosoma cruzi epsilon tubulin, putative 0.0121 0.2247 0.52
Onchocerca volvulus 0.0068 0.1167 0.31
Echinococcus multilocularis neuropeptide s receptor 0.0068 0.1167 0.1167
Echinococcus multilocularis cysteine protease 0.0023 0.0258 0.0258
Onchocerca volvulus 0.0068 0.1167 0.31
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0859 0.1962
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.2188 0.2188
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0068 0.1167 0.1167
Brugia malayi MH1 domain containing protein 0.0013 0.0063 0.0075
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Echinococcus multilocularis tubulin alpha chain 0.0169 0.3218 0.3218
Brugia malayi ABC transporter family protein 0.0011 0.0014 0.0004
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0011 0.002 0.0014
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.002 0.0013
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0011 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0068 0.1167 0.1678
Entamoeba histolytica cysteine protease, putative 0.0023 0.0258 0.0596
Onchocerca volvulus 0.0011 0.0014 0.0008
Echinococcus multilocularis g protein coupled receptor 0.0068 0.1167 0.1167
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.018 0.0245
Echinococcus granulosus g protein coupled receptor 0.0068 0.1167 0.1167
Plasmodium falciparum multidrug resistance protein 1 0.0011 0.0014 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0258 0.0565

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.03 uM In vitro inhibition of partially purified L1210 thymidylate synthase (TS). ChEMBL. 2033585
IC50 (binding) = 1.03 uM In vitro inhibition of partially purified L1210 thymidylate synthase (TS). ChEMBL. 2033585
IC50 (functional) = 2.7 uM In vitro inhibition of L1210 cell growth in culture. ChEMBL. 2033585
IC50 (functional) = 2.7 uM In vitro inhibition of L1210 cell growth in culture. ChEMBL. 2033585

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 2033585

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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