Detailed information for compound 695179

Basic information

Technical information
  • TDR Targets ID: 695179
  • Name: 9-(2,4-dimethoxyphenyl)-1-methyl-3-(2-methylp ropyl)-7,8-dihydro-6H-purino[8,7-b]pyrimidine -2,4-dione
  • MW: 413.47 | Formula: C21H27N5O4
  • H donors: 0 H acceptors: 3 LogP: 2.92 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)ccc1N1CCCn2c1nc1c2c(=O)n(c(=O)n1C)CC(C)C
  • InChi: 1S/C21H27N5O4/c1-13(2)12-26-19(27)17-18(23(3)21(26)28)22-20-24(9-6-10-25(17)20)15-8-7-14(29-4)11-16(15)30-5/h7-8,11,13H,6,9-10,12H2,1-5H3
  • InChiKey: QABFDKYWAQKYGW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 9-(2,4-dimethoxyphenyl)-3-isobutyl-1-methyl-7,8-dihydro-6H-purino[8,7-b]pyrimidine-2,4-dione
  • 9-(2,4-dimethoxyphenyl)-3-isobutyl-1-methyl-7,8-dihydro-6H-purino[8,7-b]pyrimidine-2,4-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0191 0.041
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0042 0.0142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0198 0.081 0.081
Loa Loa (eye worm) hypothetical protein 0.0145 0.0573 0.1929
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0063 0.0211
Echinococcus multilocularis phd:f box containing protein 0.0029 0.0063 0.0055
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0029 0.0064 0.0774
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0024 0.0016
Trichomonas vaginalis esterase, putative 0.0145 0.0573 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0162 0.0546
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.0042 0.0093
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0024 0.0042 0.0374
Trypanosoma cruzi DNA polymerase eta, putative 0.009 0.0333 0.4902
Mycobacterium ulcerans lipase LipD 0.0145 0.0573 0.1963
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0145 0.0573 0.1929
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0447 0.1503
Onchocerca volvulus 0.0024 0.0042 0.0736
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0024 0.0042 0.0093
Schistosoma mansoni thyroid hormone receptor 0.002 0.0024 0.0024
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0062 0.0207 0.0698
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0124 0.0481 0.7346
Echinococcus granulosus peregrin 0.0089 0.0327 0.0319
Mycobacterium ulcerans hypothetical protein 0.0032 0.0076 0.0123
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0102 0.0384 0.0376
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0638 0.2748 0.6841
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0094 0.0349 0.1175
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0198 0.081 0.0803
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0042 0.0142
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0025 0.0045 0.0142
Schistosoma mansoni ap endonuclease 0.0042 0.0122 0.0122
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0296 0.0939
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0924 0.4004 1
Brugia malayi cytosol aminopeptidase 0.0025 0.0045 0.0152
Schistosoma mansoni lamin 0.0027 0.0055 0.0055
Trypanosoma cruzi DNA polymerase kappa, putative 0.0132 0.0516 0.792
Mycobacterium tuberculosis Conserved protein 0.0145 0.0573 0.1372
Loa Loa (eye worm) hypothetical protein 0.0061 0.0205 0.0691
Schistosoma mansoni cpg binding protein 0.007 0.0244 0.0244
Trypanosoma brucei DNA polymerase IV, putative 0.0124 0.0483 0.7379
Loa Loa (eye worm) jmjC domain-containing protein 0.0183 0.0743 0.25
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0037 0.0029
Echinococcus granulosus leucyl aminopeptidase 0.0025 0.0045 0.0037
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0024 0.0016
Loa Loa (eye worm) hypothetical protein 0.0026 0.0052 0.0175
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0109 0.0417 0.0979
Loa Loa (eye worm) hypothetical protein 0.0089 0.0327 0.1101
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0053 0.0265
Echinococcus multilocularis survival motor neuron protein 1 0.0482 0.2058 0.2051
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0037 0.0272
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0082 0.0296 0.0939
Brugia malayi jmjC domain containing protein 0.0111 0.0426 0.1433
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0285 0.4949
Trypanosoma brucei hypothetical protein, conserved 0.0145 0.0573 0.8866
Brugia malayi ImpB/MucB/SamB family protein 0.016 0.0642 0.216
Echinococcus granulosus insulin receptor 0.022 0.0907 0.0899
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0076 0.0643
Loa Loa (eye worm) beta-lactamase 0.0145 0.0573 0.1929
Echinococcus granulosus beta LACTamase domain containing family member 0.0145 0.0573 0.0566
Echinococcus multilocularis L aminoadipate semialdehyde 0.0094 0.0349 0.0341
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0055 0.0185
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0227 0.0765
Brugia malayi jmjC domain containing protein 0.0291 0.1216 0.4091
Echinococcus granulosus pyruvate kinase 0.0038 0.0102 0.0094
Trypanosoma cruzi DNA damage repair protein, putative 0.0032 0.0076 0.0643
Echinococcus multilocularis dnaJ subfamily B 0.094 0.4076 0.4072
Loa Loa (eye worm) hypothetical protein 0.0026 0.0053 0.0177
Plasmodium falciparum pyruvate kinase 0.0038 0.0102 0.1752
Echinococcus multilocularis dna polymerase eta 0.016 0.0642 0.0634
Echinococcus multilocularis dna polymerase kappa 0.0132 0.0516 0.0508
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0638 0.2748 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0053 0.0039
Loa Loa (eye worm) hypothetical protein 0.0094 0.0349 0.1175
Echinococcus granulosus jumonji domain containing protein 0.0123 0.048 0.0472
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0052 0.0445
Trypanosoma cruzi DNA polymerase kappa, putative 0.0132 0.0516 0.792
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0053 0.0563
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.001 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0063 0.0211
Brugia malayi nuclear hormone receptor 0.002 0.0024 0.0081
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0102 0.1083
Toxoplasma gondii ABC1 family protein 0.0145 0.0573 1
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0037 0.0123
Loa Loa (eye worm) hypothetical protein 0.0061 0.0205 0.0691
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0024 0.0081
Brugia malayi beta-lactamase family protein 0.0145 0.0573 0.1929
Schistosoma mansoni hypothetical protein 0.0089 0.0327 0.0327
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0082 0.0296 0.0997
Loa Loa (eye worm) RNA binding protein 0.0066 0.0227 0.0765
Onchocerca volvulus 0.0145 0.0573 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0689 0.2972 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0024 0.0016
Leishmania major hypothetical protein, conserved 0.0145 0.0573 0.8866
Toxoplasma gondii ImpB/MucB/SamB family protein 0.009 0.0333 0.5651
Echinococcus multilocularis 0.0213 0.0876 0.0869
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0025 0.0045 0.0037
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0206 0.0693
Onchocerca volvulus 0.0098 0.0369 0.6442
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0032 0.0079 0.0071
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0198 0.081 0.0803
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.0045 0.0142
Trypanosoma brucei aminopeptidase, putative 0.0025 0.0045 0.0142
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0145 0.0573 0.1963
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0102 0.1782
Echinococcus granulosus dual specificity 0.0101 0.0379 0.0372
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0124 0.0481 0.8332
Giardia lamblia Sgs1 DNA helicase, putative 0.0023 0.0037 0.038
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0082 0.1095
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.0063 0.0894
Echinococcus granulosus cpg binding protein 0.007 0.0244 0.0236
Loa Loa (eye worm) hypothetical protein 0.0035 0.009 0.0302
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0024 0.0042 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.0516 0.792
Plasmodium falciparum M17 leucyl aminopeptidase 0.0124 0.0481 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.006 0.0999
Chlamydia trachomatis pyruvate kinase 0.0038 0.0102 0.1155
Mycobacterium tuberculosis Conserved hypothetical protein 0.0117 0.0452 0.1068
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.025 0.025
Echinococcus multilocularis lamin 0.0027 0.0055 0.0047
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0063 0.0211
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0037 0.0123
Plasmodium vivax hypothetical protein, conserved 0.0145 0.0573 1
Mycobacterium leprae conserved hypothetical protein 0.0145 0.0573 0.1963
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0024 0.0042 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0024 0.0081
Mycobacterium leprae Probable pyruvate kinase PykA 0.0038 0.0102 0.0222
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0024 0.0081
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0024 0.0024
Schistosoma mansoni terminal deoxycytidyl transferase 0.0102 0.0384 0.0384
Echinococcus granulosus lysine specific demethylase 6a 0.0029 0.0063 0.0055
Echinococcus granulosus endonuclease exonuclease phosphatase 0.022 0.0907 0.0899
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.0573 1
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0101 0.0379 0.5664
Leishmania major pyruvate kinase 0.0038 0.0102 0.1083
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0045 0.0037
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0227 0.0765
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0102 0.0384 0.1292
Schistosoma mansoni lamin 0.0027 0.0055 0.0055
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0053 0.0039
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0024 0.0016
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0042 0.0142
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0198 0.081 0.0803
Schistosoma mansoni phd/f-box containing protein 0.0029 0.0063 0.0063
Schistosoma mansoni DNA polymerase eta 0.016 0.0642 0.0642
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0122 0.2092
Echinococcus granulosus lysine specific demethylase 5A 0.0111 0.0426 0.0418
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0027
Loa Loa (eye worm) hypothetical protein 0.0054 0.0173 0.0583
Onchocerca volvulus 0.0027 0.0055 0.0955
Loa Loa (eye worm) RecQ helicase 0.0023 0.0037 0.0123
Brugia malayi jmjC domain containing protein 0.0029 0.0063 0.0211
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0037 0.0029
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0198 0.081 0.2725
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0024 0.0042 0.0037
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.022 0.0907 0.0899
Loa Loa (eye worm) hypothetical protein 0.01 0.0377 0.1269
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0145 0.0573 0.1372
Mycobacterium ulcerans esterase/lipase LipP 0.0145 0.0573 0.1963
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0024 0.0081
Onchocerca volvulus 0.0094 0.0349 0.609
Schistosoma mansoni hypothetical protein 0.0071 0.025 0.025
Schistosoma mansoni pyruvate kinase 0.0019 0.0022 0.0022
Brugia malayi beta-lactamase family protein 0.0145 0.0573 0.1929
Entamoeba histolytica acyl-coA synthetase, putative 0.0082 0.0296 0.7471
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0082 0.0296 0.0676
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0042 0.0122 0.2539
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0145 0.0573 0.1372
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0122 0.1819
Brugia malayi Bromodomain containing protein 0.0089 0.0327 0.1101
Plasmodium falciparum DNA repair protein REV1, putative 0.0032 0.0076 0.1173
Brugia malayi TAR-binding protein 0.0066 0.0227 0.0765
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0042 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.0516 0.792
Mycobacterium tuberculosis Conserved hypothetical protein 0.0102 0.0384 0.0897
Schistosoma mansoni tyrosine kinase 0.0367 0.155 0.155
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0207 0.2822
Schistosoma mansoni phosphatidylserine receptor 0.0029 0.0063 0.0063
Onchocerca volvulus 0.0082 0.0296 0.5166
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0025 0.0045 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0024 0.0081
Onchocerca volvulus 0.0027 0.0055 0.0955
Brugia malayi Protein kinase domain containing protein 0.0101 0.0379 0.1277
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0025 0.0045 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0024 0.0081
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0227 0.0765
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0042 0.0093
Entamoeba histolytica hypothetical protein 0.0101 0.0379 0.9866
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.025 0.0242
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0029 0.0063 0.0063
Brugia malayi Pyruvate kinase, M2 isozyme 0.0038 0.0102 0.0344
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0207 0.2822
Mycobacterium tuberculosis Probable lipase LipE 0.0145 0.0573 0.1372
Brugia malayi PHD-finger family protein 0.0033 0.0081 0.0272
Loa Loa (eye worm) hypothetical protein 0.0035 0.0091 0.0306
Brugia malayi beta-lactamase 0.0145 0.0573 0.1929
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Entamoeba histolytica protein kinase, putative 0.0101 0.0379 0.9866
Schistosoma mansoni tyrosine kinase 0.022 0.0907 0.0907
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0024 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.0516 0.792
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0206 0.0198
Loa Loa (eye worm) hypothetical protein 0.0038 0.0102 0.0344
Loa Loa (eye worm) hypothetical protein 0.0145 0.0573 0.1929
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0122 0.2092
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Echinococcus multilocularis geminin 0.1291 0.5621 0.5618
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0173 0.0583
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0024 0.042
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0025 0.0045 0.0142
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0102 0.1746
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0025 0.0045 0.0152
Loa Loa (eye worm) hypothetical protein 0.0061 0.0205 0.0691
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0045 0.0037
Entamoeba histolytica acyl-CoA synthetase, putative 0.0082 0.0296 0.7471
Mycobacterium ulcerans beta-lactamase 0.0145 0.0573 0.1963
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0102 0.0344
Schistosoma mansoni survival motor neuron protein 0.0098 0.0369 0.0369
Toxoplasma gondii propionate-CoA ligase 0.0024 0.0042 0.0374
Echinococcus granulosus leucine aminopeptidase protein 0.0124 0.0481 0.0474
Echinococcus multilocularis pyruvate kinase 0.0038 0.0102 0.0094
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0037 0.0029
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0024 0.0024
Schistosoma mansoni pyruvate kinase 0.0038 0.0102 0.0102
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0102 0.1782
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0227 0.0227
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.0122 0.141
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0032 0.0079 0.0071
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0027 0.0019
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0124 0.0481 0.7346
Loa Loa (eye worm) heterochromatin protein 1 0.0079 0.0285 0.0959
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0132 0.2267
Schistosoma mansoni tyrosine kinase 0.037 0.1567 0.1567
Schistosoma mansoni hypothetical protein 0.0016 0.0008 0.0008
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0102 0.0344
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.0122 0.141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0198 0.081 0.081
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0024 0.0042 0.0162
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0147 0.2527
Schistosoma mansoni tyrosine kinase 0.0689 0.2972 0.2972
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0573 1
Onchocerca volvulus 0.0145 0.0573 1
Echinococcus multilocularis pyruvate kinase 0.0038 0.0102 0.0094
Plasmodium vivax acetyl-CoA synthetase, putative 0.0024 0.0042 0.0374
Leishmania major DNA polymerase kappa, putative 0.0032 0.0076 0.0643
Echinococcus multilocularis musashi 0.0027 0.0055 0.0047
Schistosoma mansoni DNA polymerase IV / kappa 0.0032 0.0076 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0417 0.6281
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0024 0.0081
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.006 0.0999
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0101 0.0379 0.1277
Echinococcus multilocularis cpg binding protein 0.007 0.0244 0.0236
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.0516 0.792
Schistosoma mansoni leucine aminopeptidase 0.0025 0.0045 0.0045
Brugia malayi MH2 domain containing protein 0.0116 0.0447 0.1503
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0076 0.0977
Echinococcus multilocularis jumonji domain containing protein 0.0123 0.048 0.0472
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0061 0.0205 0.0447
Leishmania major hypothetical protein, conserved 0.0029 0.0063 0.0431
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0278 0.3987
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.0042 0.0093
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0271 0.1132 0.3808
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0024 0.0016
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0145 0.0573 0.1929
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0296 0.0997
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0076 0.0643
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0024 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0573 0.8866
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0024 0.0081
Echinococcus granulosus intermediate filament protein 0.0027 0.0055 0.0047
Plasmodium falciparum acyl-CoA synthetase 0.0061 0.0205 0.3997
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0206 0.0198
Brugia malayi ImpB/MucB/SamB family protein 0.0102 0.0384 0.1292
Trypanosoma cruzi DNA polymerase eta, putative 0.016 0.0642 1
Schistosoma mansoni jumonji domain containing protein 0.0029 0.0063 0.0063
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0102 0.0384 0.0376
Mycobacterium tuberculosis Probable lipase LipD 0.0145 0.0573 0.1372
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Schistosoma mansoni jumonji domain containing protein 0.0231 0.0953 0.0953
Entamoeba histolytica hypothetical protein 0.0071 0.025 0.6139
Echinococcus multilocularis jumonji domain containing 1A 0.0029 0.0063 0.0055
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0061 0.0205 0.3561
Loa Loa (eye worm) hypothetical protein 0.0482 0.2058 0.6924
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0033 0.0082 0.1315
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.0516 0.792
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0296 0.0676
Onchocerca volvulus 0.0024 0.0042 0.0736
Schistosoma mansoni hypothetical protein 0.1291 0.5621 0.5621
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0025 0.0045 0.0152
Schistosoma mansoni hypothetical protein 0.0016 0.0008 0.0008
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0206 0.0198
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0024 0.0081
Echinococcus granulosus L aminoadipate semialdehyde 0.0094 0.0349 0.0341
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0024 0.0016
Echinococcus multilocularis JmjC domain containing protein 4 0.0029 0.0063 0.0055
Echinococcus multilocularis epidermal growth factor receptor 0.037 0.1567 0.1561
Brugia malayi Furin-like cysteine rich region family protein 0.0689 0.2972 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0132 0.0516 0.792
Leishmania major DNA polymerase eta, putative 0.009 0.0333 0.4902
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0198 0.081 0.0803
Brugia malayi RNA binding protein 0.0066 0.0227 0.0765
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0064 0.0458
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0024 0.042
Plasmodium vivax pyruvate kinase, putative 0.0038 0.0102 0.146
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.0573 0.0573
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0076 0.0643
Mycobacterium leprae Probable lipase LipE 0.0145 0.0573 0.1963
Echinococcus granulosus pyruvate kinase 0.0019 0.0022 0.0014
Schistosoma mansoni tyrosine kinase 0.0367 0.155 0.155
Echinococcus granulosus lamin dm0 0.0027 0.0055 0.0047
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0082 0.0296 0.0939
Brugia malayi F/Y-rich N-terminus family protein 0.0049 0.0153 0.0515
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0042 0.0122 0.0237
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0024 0.0016
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.006 0.0999
Schistosoma mansoni protein phosphatase 2C 0.0029 0.0063 0.0063
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0042 0.0122 0.0257
Echinococcus granulosus pyruvate kinase 0.0019 0.0022 0.0014
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0029 0.0464
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0101 0.0379 0.5664
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0198 0.081 0.2725
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.0516 0.792
Echinococcus multilocularis peregrin 0.0089 0.0327 0.0319
Onchocerca volvulus 0.002 0.0024 0.042
Brugia malayi CHD4 protein 0.0017 0.001 0.0035
Giardia lamblia Pyruvate kinase 0.0038 0.0102 0.2038
Trypanosoma brucei DNA polymerase IV, putative 0.0132 0.0516 0.792
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0369 0.1243
Treponema pallidum licC protein (licC) 0.0117 0.0452 1
Leishmania major pyruvate kinase 0.0038 0.0102 0.1083
Schistosoma mansoni hypothetical protein 0.0335 0.1413 0.1413
Brugia malayi steroid hormone receptor 0.002 0.0024 0.0081
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0296 0.0939
Trypanosoma brucei pyruvate kinase 1 0.0038 0.0102 0.1083
Brugia malayi jmjC domain containing protein 0.0029 0.0063 0.0211
Schistosoma mansoni hypothetical protein 0.0098 0.0369 0.0369
Echinococcus granulosus epidermal growth factor receptor 0.037 0.1567 0.1561
Mycobacterium ulcerans DNA polymerase IV 0.0132 0.0516 0.1751
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0008 0.0027
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0037 0.0597
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0038 0.0102 0.0188
Mycobacterium ulcerans hypothetical protein 0.0145 0.0573 0.1963
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0029 0.0464
Plasmodium vivax acyl-CoA synthetase, putative 0.0061 0.0205 0.333
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0024 0.042
Schistosoma mansoni hypothetical protein 0.1291 0.5621 0.5621
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0227 0.0227
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0042 0.0122 0.2456
Onchocerca volvulus 0.0035 0.009 0.1565
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0042 0.0037
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0024 0.0081
Mycobacterium ulcerans leucyl aminopeptidase 0.0124 0.0481 0.1623
Schistosoma mansoni tyrosine kinase 0.0367 0.155 0.155
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0191 0.041
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0024 0.0042 0.0037
Plasmodium vivax DNA repair protein REV1, putative 0.0032 0.0076 0.0977
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0024 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0296 0.0939
Schistosoma mansoni hypothetical protein 0.0016 0.0008 0.0008
Toxoplasma gondii pyruvate kinase PyK1 0.0038 0.0102 0.146
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0122 0.2183
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0009 0.0001
Schistosoma mansoni hypothetical protein 0.0029 0.0064 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0198 0.081 0.081
Schistosoma mansoni coup transcription factor 0.002 0.0024 0.0024
Leishmania major DNA polymerase eta, putative 0.016 0.0642 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0296 0.0997
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0042 0.0122 0.0295
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0082 0.0296 0.0939
Brugia malayi intermediate filament protein 0.0027 0.0055 0.0185
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0024 0.0016
Loa Loa (eye worm) hypothetical protein 0.0082 0.0296 0.0997
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0173 0.0165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0024 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0379 0.0379
Brugia malayi mbt repeat family protein 0.0054 0.0173 0.0583
Loa Loa (eye worm) jmjC domain-containing protein 0.0111 0.0426 0.1433
Echinococcus multilocularis lysine specific demethylase 5A 0.0107 0.0409 0.0402
Echinococcus granulosus PHD finger protein rhinoceros 0.0089 0.0327 0.0319
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0009 0.0001
Schistosoma mansoni hypothetical protein 0.094 0.4076 0.4076
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0102 0.0344
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0025 0.0045 0.0142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0024 0.0081
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0037 0.0029
Brugia malayi polk-prov protein 0.0062 0.0207 0.0698
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0173 0.0173
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0037 0.0597
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0117 0.0452 0.7803
Trypanosoma cruzi DNA polymerase kappa, putative 0.0132 0.0516 0.792
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0089 0.0327 0.0327
Echinococcus granulosus dnaJ subfamily B 0.094 0.4076 0.4072
Schistosoma mansoni mixed-lineage leukemia protein mll 0.014 0.0553 0.0553
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0227 0.0227
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0024 0.0016
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0173 0.3023
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0024 0.0016
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0024 0.0024
Trypanosoma brucei unspecified product 0.0124 0.0483 0.7379
Brugia malayi Pyruvate kinase, muscle isozyme 0.0038 0.0102 0.0344
Echinococcus granulosus dna polymerase eta 0.016 0.0642 0.0634
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0162 0.0546
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0296 0.4288
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0024 0.0042 0.0037
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0029 0.0063 0.0745
Brugia malayi follicle stimulating hormone receptor 0.0271 0.1132 0.3808
Entamoeba histolytica hypothetical protein 0.0071 0.025 0.6139
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0053 0.0063
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0024 0.0042 0.0449
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0124 0.0481 0.7346
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0055 0.0185
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.0573 0.0573
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0024 0.0081
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.001 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.006 0.0999
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0296 0.0997
Brugia malayi CXXC zinc finger family protein 0.0066 0.0227 0.0765
Trypanosoma brucei unspecified product 0.007 0.0245 0.3446
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0145 0.0573 0.1372
Giardia lamblia DNA damage repair protein 0.0032 0.0076 0.1364
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0094 0.0349 0.0349
Onchocerca volvulus 0.0066 0.0227 0.3965
Entamoeba histolytica hypothetical protein 0.0026 0.0053 0.0462
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.0122 0.141
Giardia lamblia DINP protein human, muc B family 0.0109 0.0417 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.0573 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.0122 0.041
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0296 0.4288
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0447 0.1503
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0029 0.0063 0.0745
Schistosoma mansoni cpg binding protein 0.0066 0.0227 0.0227
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0042 0.0093
Echinococcus granulosus survival motor neuron protein 1 0.0482 0.2058 0.2051
Brugia malayi Heterochromatin protein 1 0.0079 0.0285 0.0959
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0109 0.0417 0.6281
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.037 0.1567 0.1561
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0173 0.0165
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.006 0.0999
Brugia malayi PHD-finger family protein 0.0089 0.0327 0.1101
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0142
Echinococcus multilocularis leucine aminopeptidase protein 0.0124 0.0481 0.0474
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0024 0.038
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0024 0.0081
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0638 0.2748 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0024 0.0016
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0037 0.0029
Trichomonas vaginalis DNA polymerase eta, putative 0.0132 0.0516 0.8996
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0053 0.0563
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0102 0.1746
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.006 0.0999
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0024 0.0024
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0124 0.0481 0.1141
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0082 0.0296 0.0939
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0173 0.0173
Echinococcus granulosus chromobox protein 1 0.0079 0.0285 0.0277
Toxoplasma gondii histone lysine methyltransferase SET1 0.0125 0.0487 0.8442
Echinococcus multilocularis microtubule associated protein 2 0.2286 1 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0037 0.0326
Plasmodium falciparum phd finger protein, putative 0.0089 0.0327 0.6648
Schistosoma mansoni microtubule-associated protein tau 0.2286 1 1
Brugia malayi mbt repeat family protein 0.0054 0.0173 0.0583
Schistosoma mansoni DNA helicase recq1 0.0023 0.0037 0.0037
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0227 0.022
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0053 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0024 0.0081
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0296 0.0997
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0042 0.0037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0024 0.0016
Schistosoma mansoni jumonji/arid domain-containing protein 0.0111 0.0426 0.0426
Leishmania major DNA damage repair protein, putative 0.0032 0.0076 0.0643
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0024 0.0024
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.0122 0.041
Echinococcus multilocularis pyruvate kinase 0.0019 0.0022 0.0014
Echinococcus multilocularis chromobox protein 1 0.0079 0.0285 0.0277
Echinococcus multilocularis pyruvate kinase 0.0019 0.0022 0.0014
Trypanosoma brucei DNA polymerase IV, putative 0.0132 0.0516 0.792
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.0516 0.792
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0091 0.0306
Loa Loa (eye worm) PHD-finger family protein 0.0089 0.0327 0.1101
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0024 0.0081
Echinococcus granulosus epidermal growth factor receptor 0.0689 0.2972 0.2966
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0291 0.1216 0.1209
Echinococcus granulosus phd:f box containing protein 0.0029 0.0063 0.0055
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0123
Loa Loa (eye worm) hypothetical protein 0.0145 0.0573 0.1929
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0075 0.1268
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0053 0.0676
Mycobacterium ulcerans hypothetical protein 0.0117 0.0452 0.1515
Loa Loa (eye worm) hypothetical protein 0.0145 0.0573 0.1929
Onchocerca volvulus Alhambra homolog 0.0089 0.0327 0.5707
Plasmodium vivax hypothetical protein, conserved 0.0089 0.0327 0.5539
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0024 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0278 0.3987
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0024 0.0042 0.0037
Schistosoma mansoni chromobox protein 0.0079 0.0285 0.0285
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0101 0.0379 0.5664
Schistosoma mansoni tyrosine kinase 0.022 0.0907 0.0907
Schistosoma mansoni hypothetical protein 0.0016 0.0008 0.0008
Onchocerca volvulus 0.0145 0.0573 1
Trypanosoma brucei DNA polymerase eta, putative 0.016 0.0642 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.022 0.0907 0.0899
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0573 0.8866
Brugia malayi ecdysteroid receptor 0.002 0.0024 0.0081
Loa Loa (eye worm) hypothetical protein 0.0145 0.0573 0.1929
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0024 0.0081
Echinococcus granulosus JmjC domain containing protein 4 0.0029 0.0063 0.0055
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0024 0.0042 0.0037
Echinococcus granulosus dna polymerase kappa 0.0132 0.0516 0.0508
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0102 0.1083
Brugia malayi hypothetical protein 0.0071 0.025 0.0841
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0042 0.0142
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0024 0.0042 0.0374
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0327 0.5539
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0132 0.2301
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0278 0.3987
Loa Loa (eye worm) CXXC zinc finger family protein 0.0066 0.0227 0.0765
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0053 0.0563
Loa Loa (eye worm) hypothetical protein 0.0152 0.0606 0.204
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0147 0.256
Loa Loa (eye worm) hypothetical protein 0.01 0.0377 0.1269
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0024 0.0081
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0099 0.0334
Entamoeba histolytica acyl-CoA synthetase, putative 0.0082 0.0296 0.7471
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0029 0.0063 0.0431
Toxoplasma gondii exonuclease III APE 0.0042 0.0122 0.1819
Echinococcus granulosus chromobox protein 1 0.0079 0.0285 0.0277
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0024 0.0081
Loa Loa (eye worm) hypothetical protein 0.0061 0.0206 0.0693
Schistosoma mansoni chromobox protein 0.0079 0.0285 0.0285
Schistosoma mansoni nuclear hormone receptor 0.002 0.0024 0.0024
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.025 0.0242
Loa Loa (eye worm) TK/INSR protein kinase 0.022 0.0907 0.3051
Echinococcus granulosus tar DNA binding protein 0.0066 0.0227 0.022
Mycobacterium ulcerans pyruvate kinase 0.0038 0.0102 0.0222
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0082 0.0296 0.0939
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0063 0.0431
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.001 0.0002
Mycobacterium tuberculosis Probable hydrolase 0.0145 0.0573 0.1372
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0024 0.0042 0.0142
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0173 0.0173
Trypanosoma brucei DNA damage repair protein, putative 0.0032 0.0076 0.0643
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0124 0.0481 0.1623
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.0042 0.0093
Onchocerca volvulus 0.0054 0.0173 0.3023
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0025 0.0045 0.0152
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0037 0.0326
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0147 0.2527
Loa Loa (eye worm) hypothetical protein 0.0033 0.0081 0.0272
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0008 0.0027
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0052 0.0175
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0053 0.0265
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0037 0.0597
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0291 0.1216 0.1209
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0075 0.1268
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.0122 0.0114
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0173 0.0165
Schistosoma mansoni hypothetical protein 0.0035 0.0091 0.0091
Schistosoma mansoni acetyl-CoA synthetase 0.0024 0.0042 0.0042
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.0122 0.1734
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0024 0.0042 0.0037
Loa Loa (eye worm) hypothetical protein 0.016 0.0642 0.216
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0024 0.0081
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0042 0.0037
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0102 0.1782
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0039 0.0108 0.1571
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.0045 0.0142
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0124 0.0481 0.159
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0162 0.0546
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0206 0.0206
Brugia malayi hypothetical protein 0.0482 0.2058 0.6924
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0327 0.5539
Mycobacterium ulcerans hypothetical protein 0.0082 0.0296 0.0939
Entamoeba histolytica hypothetical protein 0.0071 0.025 0.6139
Mycobacterium ulcerans DNA polymerase IV 0.0132 0.0516 0.1751
Echinococcus multilocularis pyruvate kinase 0.003 0.0067 0.0059
Echinococcus multilocularis epidermal growth factor receptor 0.0689 0.2972 0.2966
Echinococcus multilocularis beta LACTamase domain containing family member 0.0145 0.0573 0.0566
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0573 1
Echinococcus multilocularis insulin receptor 0.022 0.0907 0.0899
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0024 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0042 0.0142
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0009 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.0516 0.792
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.0516 0.792
Echinococcus multilocularis PHD finger protein rhinoceros 0.0089 0.0327 0.0319
Brugia malayi AF-10 protein 0.0029 0.0064 0.0217
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0064 0.0774
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0008 0.0027
Loa Loa (eye worm) hypothetical protein 0.0061 0.0205 0.0691
Plasmodium vivax JmjC domain containing protein 0.0029 0.0063 0.0745
Echinococcus granulosus leucyl aminopeptidase 0.0025 0.0045 0.0037
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0102 0.0384 0.0384
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.006 0.0999
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.0122 0.0114
Echinococcus granulosus pyruvate kinase 0.0038 0.0102 0.0094
Entamoeba histolytica protein kinase domain containing protein 0.0101 0.0379 0.9866
Echinococcus multilocularis chromobox protein 1 0.0079 0.0285 0.0277
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0076 0.0643
Loa Loa (eye worm) MBCTL1 0.0061 0.0206 0.0693
Schistosoma mansoni jumonji/arid domain-containing protein 0.0111 0.0426 0.0426
Toxoplasma gondii leucyl aminopeptidase LAP 0.0124 0.0481 0.8332
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0025 0.0045 0.0142
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0117 0.0452 0.1515
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0037 0.0123
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0037 0.0123
Mycobacterium tuberculosis Conserved hypothetical protein 0.0117 0.0452 0.1068
Brugia malayi chromobox protein homolog 3 0.0044 0.0132 0.0444
Mycobacterium tuberculosis Conserved protein 0.0145 0.0573 0.1372
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0024 0.0016
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.001 0.001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.006 0.0999
Echinococcus multilocularis lysine specific demethylase 6a 0.0029 0.0063 0.0055
Echinococcus multilocularis lamin dm0 0.0027 0.0055 0.0047
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0227 0.0227
Chlamydia trachomatis cytosol aminopeptidase 0.0124 0.0481 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0024 0.0081
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0132 0.0516 0.8996
Echinococcus granulosus lamin 0.0027 0.0055 0.0047
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0045 0.0037
Echinococcus granulosus insulin growth factor 1 receptor beta 0.022 0.0907 0.0899
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0055 0.0185
Mycobacterium tuberculosis Conserved protein 0.0145 0.0573 0.1372
Entamoeba histolytica hypothetical protein 0.0071 0.025 0.6139
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0191 0.041
Brugia malayi jmjC domain containing protein 0.0029 0.0063 0.0211
Entamoeba histolytica deoxycytidyl transferase, putative 0.0102 0.0384 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0227 0.0227
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.0042 0.0093
Mycobacterium tuberculosis Probable esterase LipL 0.0145 0.0573 0.1372
Brugia malayi Protein kinase domain containing protein 0.022 0.0907 0.3051
Schistosoma mansoni tyrosine kinase 0.037 0.1567 0.1567
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0024 0.0081
Trypanosoma brucei pyruvate kinase 1, putative 0.0038 0.0102 0.1083
Loa Loa (eye worm) hypothetical protein 0.0145 0.0573 0.1929
Echinococcus granulosus geminin 0.1291 0.5621 0.5618
Trypanosoma cruzi DNA damage repair protein, putative 0.0032 0.0076 0.0643
Trypanosoma brucei chrX additional, unordered contigs 0.0032 0.0076 0.0643
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0124 0.0481 0.7346
Trypanosoma brucei unspecified product 0.007 0.0245 0.3446
Echinococcus multilocularis dual specificity 0.0101 0.0379 0.0372
Echinococcus granulosus FTZ F1 alpha 0.002 0.0024 0.0016
Giardia lamblia PHD finger protein 15 0.0089 0.0327 0.7733
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0042 0.0093
Loa Loa (eye worm) histone methyltransferase 0.002 0.0027 0.009
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0024 0.0081
Loa Loa (eye worm) hypothetical protein 0.0029 0.0063 0.0211
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0024 0.0016
Loa Loa (eye worm) hypothetical protein 0.0044 0.0132 0.0444
Echinococcus multilocularis pyruvate kinase 0.0019 0.0022 0.0014
Echinococcus granulosus pyruvate kinase 0.0019 0.0022 0.0014
Leishmania major DNA polymerase kappa, putative 0.0109 0.0417 0.6281
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0296 0.4288
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0024 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0132 0.2267
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0009 0.0001
Onchocerca volvulus 0.0024 0.0042 0.0736
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0285 0.4949
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.0042 0.0696
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0191 0.041
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0063 0.0431
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.0045 0.0142
Schistosoma mansoni DNA helicase recq5 0.0023 0.0037 0.0037
Mycobacterium ulcerans hypothetical protein 0.0117 0.0452 0.1515
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0042 0.0037
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0101 0.0379 0.5664
Entamoeba histolytica protein kinase, putative 0.0101 0.0379 0.9866
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0042 0.0142
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0027 0.0019
Schistosoma mansoni thyroid hormone receptor 0.002 0.0024 0.0024
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0037 0.0272
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0638 0.2748 1
Onchocerca volvulus 0.0024 0.0042 0.0736
Loa Loa (eye worm) hypothetical protein 0.0061 0.0205 0.0691
Loa Loa (eye worm) hypothetical protein 0.0029 0.0063 0.0211
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0061 0.0205 0.0603
Schistosoma mansoni intermediate filament proteins 0.0027 0.0055 0.0055
Trypanosoma brucei DNA damage repair protein, putative 0.0032 0.0076 0.0643
Echinococcus granulosus jumonji domain containing 1A 0.0029 0.0063 0.0055
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0162 0.0546
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0064 0.0458
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0573 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.0122 0.141
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0042 0.0142
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0082 0.0296 0.0939
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0173 0.0165
Loa Loa (eye worm) oxidoreductase 0.0024 0.0042 0.0142
Schistosoma mansoni pyruvate kinase 0.0038 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0142
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0024 0.0042 0.0034
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0045 0.0137 0.0136
Schistosoma mansoni cpg binding protein 0.007 0.0244 0.0244
Schistosoma mansoni ap endonuclease 0.0042 0.0122 0.0122
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.0042 0.0696
Echinococcus granulosus bloom syndrome protein 0.0023 0.0037 0.0029
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0206 0.0198
Brugia malayi nuclear receptor NHR-88 0.002 0.0024 0.0081
Loa Loa (eye worm) hypothetical protein 0.0027 0.0055 0.0185
Brugia malayi jmjC domain containing protein 0.0029 0.0063 0.0211

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.