Detailed information for compound 695376

Basic information

Technical information
  • TDR Targets ID: 695376
  • Name: 9-(2,4-dimethoxyphenyl)-1-methyl-3-propyl-7,8 -dihydro-6H-purino[8,7-b]pyrimidine-2,4-dione
  • MW: 399.444 | Formula: C20H25N5O4
  • H donors: 0 H acceptors: 3 LogP: 2.48 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1c(=O)n(C)c2c(c1=O)n1CCCN(c1n2)c1ccc(cc1OC)OC
  • InChi: 1S/C20H25N5O4/c1-5-9-25-18(26)16-17(22(2)20(25)27)21-19-23(10-6-11-24(16)19)14-8-7-13(28-3)12-15(14)29-4/h7-8,12H,5-6,9-11H2,1-4H3
  • InChiKey: CGVXSCWTNUSLDU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 9-(2,4-dimethoxyphenyl)-1-methyl-3-propyl-7,8-dihydro-6H-purino[8,7-b]pyrimidine-2,4-quinone
  • STOCK5S-78796
  • BAS 12521574

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0024 0.0042 0.0037
Echinococcus granulosus peregrin 0.0089 0.0327 0.0319
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0053 0.0063
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0037 0.0597
Schistosoma mansoni hypothetical protein 0.0016 0.0008 0.0008
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0327 0.5539
Loa Loa (eye worm) PHD-finger family protein 0.0089 0.0327 0.1101
Schistosoma mansoni phd/f-box containing protein 0.0029 0.0063 0.0063
Brugia malayi steroid hormone receptor 0.002 0.0024 0.0081
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0024 0.0042 0.0093
Schistosoma mansoni hypothetical protein 0.0335 0.1413 0.1413
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0206 0.0198
Giardia lamblia Sgs1 DNA helicase, putative 0.0023 0.0037 0.038
Brugia malayi Furin-like cysteine rich region family protein 0.0689 0.2972 1
Trypanosoma brucei DNA damage repair protein, putative 0.0032 0.0076 0.0643
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0042 0.0122 0.2539
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.0516 0.792
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.0045 0.0142
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0025 0.0045 0.0142
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0206 0.0198
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0124 0.0481 0.1141
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.001 0.0035
Onchocerca volvulus 0.0145 0.0573 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0024 0.0081
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0191 0.041
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0024 0.042
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0147 0.2527
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0024 0.0042 0.0034
Leishmania major DNA damage repair protein, putative 0.0032 0.0076 0.0643
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0025 0.0045 0.0152
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0094 0.0349 0.0349
Onchocerca volvulus 0.0024 0.0042 0.0736
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.0516 0.792
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0145 0.0573 0.1929
Loa Loa (eye worm) heterochromatin protein 1 0.0079 0.0285 0.0959
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0109 0.0417 0.0979
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0285 0.4949
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0024 0.0016
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0037 0.0123
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0037 0.0029
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0024 0.0016
Echinococcus granulosus pyruvate kinase 0.0038 0.0102 0.0094
Mycobacterium tuberculosis Conserved hypothetical protein 0.0102 0.0384 0.0897
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0075 0.1268
Schistosoma mansoni phosphatidylserine receptor 0.0029 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0052 0.0445
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0024 0.042
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0296 0.0997
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0042 0.0122 0.0295
Schistosoma mansoni thyroid hormone receptor 0.002 0.0024 0.0024
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0024 0.0042 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0042 0.0142
Brugia malayi Bromodomain containing protein 0.0089 0.0327 0.1101
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0024 0.0081
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0042 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0207 0.2822
Echinococcus multilocularis pyruvate kinase 0.0019 0.0022 0.0014
Echinococcus granulosus chromobox protein 1 0.0079 0.0285 0.0277
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0037 0.0123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0024 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0227 0.0227
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0198 0.081 0.081
Echinococcus granulosus tar DNA binding protein 0.0066 0.0227 0.022
Brugia malayi CXXC zinc finger family protein 0.0066 0.0227 0.0765
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0024 0.0081
Loa Loa (eye worm) hypothetical protein 0.0082 0.0296 0.0997
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0198 0.081 0.0803
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0024 0.0024
Schistosoma mansoni cpg binding protein 0.0066 0.0227 0.0227
Echinococcus granulosus dnaJ subfamily B 0.094 0.4076 0.4072
Loa Loa (eye worm) hypothetical protein 0.0145 0.0573 0.1929
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0029 0.0063 0.0063
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0008 0.0027
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0061 0.0205 0.3561
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0042 0.0142
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.022 0.0907 0.0899
Loa Loa (eye worm) hypothetical protein 0.0051 0.0162 0.0546
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0055 0.0185
Loa Loa (eye worm) CXXC zinc finger family protein 0.0066 0.0227 0.0765
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0037 0.0029
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0099 0.0334
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0227 0.0227
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0024 0.0042 0.0037
Schistosoma mansoni jumonji domain containing protein 0.0231 0.0953 0.0953
Trichomonas vaginalis esterase, putative 0.0145 0.0573 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.0122 0.141
Schistosoma mansoni chromobox protein 0.0079 0.0285 0.0285
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.006 0.0999
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0296 0.4288
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0053 0.0039
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0042 0.0142
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0227 0.0227
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0037 0.0597
Echinococcus multilocularis survival motor neuron protein 1 0.0482 0.2058 0.2051
Loa Loa (eye worm) RNA binding protein 0.0066 0.0227 0.0765
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0124 0.0481 0.7346
Echinococcus multilocularis dna polymerase eta 0.016 0.0642 0.0634
Schistosoma mansoni tyrosine kinase 0.037 0.1567 0.1567
Echinococcus multilocularis peregrin 0.0089 0.0327 0.0319
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0037 0.0123
Giardia lamblia DNA damage repair protein 0.0032 0.0076 0.1364
Schistosoma mansoni microtubule-associated protein tau 0.2286 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0024 0.0081
Loa Loa (eye worm) hypothetical protein 0.0061 0.0205 0.0691
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0573 0.8866
Loa Loa (eye worm) hypothetical protein 0.0026 0.0052 0.0175
Schistosoma mansoni tyrosine kinase 0.022 0.0907 0.0907
Echinococcus multilocularis pyruvate kinase 0.0019 0.0022 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0278 0.3987
Schistosoma mansoni hypothetical protein 0.0029 0.0064 0.0064
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0009 0.0001
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.0042 0.0093
Schistosoma mansoni hypothetical protein 0.0016 0.0008 0.0008
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.0042 0.0093
Schistosoma mansoni hypothetical protein 0.0071 0.025 0.025
Mycobacterium ulcerans DNA polymerase IV 0.0132 0.0516 0.1751
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0045 0.0037
Loa Loa (eye worm) hypothetical protein 0.0029 0.0063 0.0211
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.001 0.0002
Echinococcus granulosus insulin growth factor 1 receptor beta 0.022 0.0907 0.0899
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0296 0.4288
Echinococcus granulosus cpg binding protein 0.007 0.0244 0.0236
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0024 0.038
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Brugia malayi PHD-finger family protein 0.0033 0.0081 0.0272
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0191 0.041
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0132 0.0516 0.8996
Loa Loa (eye worm) hypothetical protein 0.0145 0.0573 0.1929
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0055 0.0185
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0024 0.0042 0.0449
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.0122 0.141
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0042 0.0122 0.0257
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0024 0.0016
Plasmodium vivax JmjC domain containing protein 0.0029 0.0063 0.0745
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0042 0.0093
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.006 0.0999
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0117 0.0452 0.7803
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0145 0.0573 0.1929
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0025 0.0045 0.0142
Loa Loa (eye worm) hypothetical protein 0.0482 0.2058 0.6924
Loa Loa (eye worm) hypothetical protein 0.0145 0.0573 0.1929
Echinococcus granulosus intermediate filament protein 0.0027 0.0055 0.0047
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0379 0.0379
Leishmania major DNA polymerase eta, putative 0.016 0.0642 1
Onchocerca volvulus 0.0145 0.0573 1
Mycobacterium ulcerans leucyl aminopeptidase 0.0124 0.0481 0.1623
Echinococcus granulosus leucine aminopeptidase protein 0.0124 0.0481 0.0474
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0042 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0024 0.0081
Echinococcus multilocularis L aminoadipate semialdehyde 0.0094 0.0349 0.0341
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0024 0.0081
Echinococcus granulosus epidermal growth factor receptor 0.0689 0.2972 0.2966
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0082 0.0296 0.0676
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0124 0.0481 0.7346
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0198 0.081 0.081
Loa Loa (eye worm) oxidoreductase 0.0024 0.0042 0.0142
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0101 0.0379 0.5664
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0206 0.0206
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.0122 0.0114
Loa Loa (eye worm) hypothetical protein 0.0054 0.0173 0.0583
Brugia malayi chromobox protein homolog 3 0.0044 0.0132 0.0444
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0024 0.0042 0.0037
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.025 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0024 0.0081
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0122 0.2183
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0033 0.0082 0.1315
Schistosoma mansoni hypothetical protein 0.0035 0.0091 0.0091
Trypanosoma brucei DNA polymerase IV, putative 0.0124 0.0483 0.7379
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0102 0.1083
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.006 0.0999
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Trypanosoma brucei aminopeptidase, putative 0.0025 0.0045 0.0142
Plasmodium falciparum acyl-CoA synthetase 0.0061 0.0205 0.3997
Leishmania major pyruvate kinase 0.0038 0.0102 0.1083
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0417 0.6281
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0296 0.0939
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0064 0.0458
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0082 0.0296 0.0939
Mycobacterium ulcerans lipase LipD 0.0145 0.0573 0.1963
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0053 0.0563
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0082 0.0296 0.0939
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0082 0.0296 0.0939
Brugia malayi jmjC domain containing protein 0.0029 0.0063 0.0211
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0037 0.0123
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0117 0.0452 0.1515
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0045 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.0516 0.792
Echinococcus granulosus phd:f box containing protein 0.0029 0.0063 0.0055
Schistosoma mansoni pyruvate kinase 0.0038 0.0102 0.0102
Mycobacterium ulcerans hypothetical protein 0.0032 0.0076 0.0123
Loa Loa (eye worm) hypothetical protein 0.0061 0.0205 0.0691
Echinococcus granulosus leucyl aminopeptidase 0.0025 0.0045 0.0037
Mycobacterium tuberculosis Probable lipase LipD 0.0145 0.0573 0.1372
Toxoplasma gondii pyruvate kinase PyK1 0.0038 0.0102 0.146
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0024 0.0042 0.0034
Echinococcus granulosus jumonji domain containing 1A 0.0029 0.0063 0.0055
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0089 0.0327 0.0327
Mycobacterium tuberculosis Probable hydrolase 0.0145 0.0573 0.1372
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0109 0.0417 0.6281
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0024 0.0081
Schistosoma mansoni leucine aminopeptidase 0.0025 0.0045 0.0045
Onchocerca volvulus 0.0066 0.0227 0.3965
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0102 0.1746
Schistosoma mansoni mixed-lineage leukemia protein mll 0.014 0.0553 0.0553
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0024 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0191 0.041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0024 0.0016
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0638 0.2748 1
Onchocerca volvulus 0.0094 0.0349 0.609
Trypanosoma cruzi DNA polymerase kappa, putative 0.0132 0.0516 0.792
Loa Loa (eye worm) hypothetical protein 0.01 0.0377 0.1269
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0101 0.0379 0.5664
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0053 0.0563
Loa Loa (eye worm) hypothetical protein 0.0145 0.0573 0.1929
Echinococcus multilocularis pyruvate kinase 0.0038 0.0102 0.0094
Schistosoma mansoni hypothetical protein 0.0098 0.0369 0.0369
Echinococcus multilocularis epidermal growth factor receptor 0.037 0.1567 0.1561
Loa Loa (eye worm) hypothetical protein 0.0061 0.0205 0.0691
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0024 0.0081
Echinococcus granulosus pyruvate kinase 0.0019 0.0022 0.0014
Loa Loa (eye worm) hypothetical protein 0.01 0.0377 0.1269
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0024 0.0081
Brugia malayi ImpB/MucB/SamB family protein 0.016 0.0642 0.216
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0173 0.0173
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0101 0.0379 0.5664
Onchocerca volvulus 0.0027 0.0055 0.0955
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0063 0.0211
Mycobacterium tuberculosis Conserved hypothetical protein 0.0117 0.0452 0.1068
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0173 0.0165
Brugia malayi ecdysteroid receptor 0.002 0.0024 0.0081
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.0122 0.141
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0024 0.0016
Schistosoma mansoni hypothetical protein 0.1291 0.5621 0.5621
Plasmodium vivax acetyl-CoA synthetase, putative 0.0024 0.0042 0.0374
Echinococcus multilocularis lamin dm0 0.0027 0.0055 0.0047
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0271 0.1132 0.3808
Schistosoma mansoni DNA polymerase eta 0.016 0.0642 0.0642
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0102 0.0344
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0206 0.0198
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.0122 0.041
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0173 0.3023
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0573 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0024 0.0016
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0037 0.0272
Brugia malayi mbt repeat family protein 0.0054 0.0173 0.0583
Loa Loa (eye worm) hypothetical protein 0.0035 0.009 0.0302
Loa Loa (eye worm) hypothetical protein 0.0038 0.0102 0.0344
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.0573 0.0573
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0052 0.0175
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Echinococcus multilocularis PHD finger protein rhinoceros 0.0089 0.0327 0.0319
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0173 0.0173
Echinococcus multilocularis lysine specific demethylase 6a 0.0029 0.0063 0.0055
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.006 0.0999
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0029 0.0064 0.0458
Loa Loa (eye worm) MBCTL1 0.0061 0.0206 0.0693
Echinococcus multilocularis jumonji domain containing protein 0.0123 0.048 0.0472
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0042 0.0037
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0042 0.0037
Echinococcus multilocularis cpg binding protein 0.007 0.0244 0.0236
Brugia malayi beta-lactamase family protein 0.0145 0.0573 0.1929
Treponema pallidum licC protein (licC) 0.0117 0.0452 1
Plasmodium falciparum DNA repair protein REV1, putative 0.0032 0.0076 0.1173
Trypanosoma cruzi DNA polymerase kappa, putative 0.0132 0.0516 0.792
Echinococcus granulosus pyruvate kinase 0.0038 0.0102 0.0094
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0063 0.0431
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0024 0.0042 0.0037
Trypanosoma brucei DNA polymerase IV, putative 0.0132 0.0516 0.792
Brugia malayi Protein kinase domain containing protein 0.0101 0.0379 0.1277
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0124 0.0481 0.1623
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0173 0.0165
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0198 0.081 0.2725
Trypanosoma brucei DNA polymerase IV, putative 0.0132 0.0516 0.792
Echinococcus granulosus L aminoadipate semialdehyde 0.0094 0.0349 0.0341
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0024 0.0042 0.0037
Echinococcus granulosus endonuclease exonuclease phosphatase 0.022 0.0907 0.0899
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0024 0.0016
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0124 0.0481 0.7346
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.022 0.0907 0.0899
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0102 0.1782
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0076 0.0643
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0024 0.0042 0.0037
Echinococcus multilocularis pyruvate kinase 0.0038 0.0102 0.0094
Giardia lamblia Pyruvate kinase 0.0038 0.0102 0.2038
Loa Loa (eye worm) hypothetical protein 0.0033 0.0081 0.0272
Schistosoma mansoni terminal deoxycytidyl transferase 0.0102 0.0384 0.0384
Brugia malayi RNA binding protein 0.0066 0.0227 0.0765
Brugia malayi PHD-finger family protein 0.0089 0.0327 0.1101
Plasmodium falciparum phd finger protein, putative 0.0089 0.0327 0.6648
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.0071 0.025 0.6139
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0296 0.0997
Echinococcus granulosus geminin 0.1291 0.5621 0.5618
Trypanosoma brucei chrX additional, unordered contigs 0.0032 0.0076 0.0643
Loa Loa (eye worm) hypothetical protein 0.016 0.0642 0.216
Loa Loa (eye worm) TK/INSR protein kinase 0.022 0.0907 0.3051
Giardia lamblia PHD finger protein 15 0.0089 0.0327 0.7733
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0061 0.0205 0.0447
Brugia malayi hypothetical protein 0.0482 0.2058 0.6924
Echinococcus multilocularis insulin receptor 0.022 0.0907 0.0899
Onchocerca volvulus 0.0054 0.0173 0.3023
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0024 0.0016
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0037 0.0029
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0102 0.0384 0.0376
Schistosoma mansoni tyrosine kinase 0.037 0.1567 0.1567
Trypanosoma cruzi DNA damage repair protein, putative 0.0032 0.0076 0.0643
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0024 0.0016
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0227 0.0765
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.025 0.025
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0227 0.0765
Leishmania major 4-coumarate:coa ligase-like protein 0.0082 0.0296 0.4288
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0145 0.0573 0.1963
Loa Loa (eye worm) hypothetical protein 0.0026 0.0053 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0024 0.0081
Toxoplasma gondii leucyl aminopeptidase LAP 0.0124 0.0481 0.8332
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0162 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0132 0.2267
Schistosoma mansoni thyroid hormone receptor 0.002 0.0024 0.0024
Schistosoma mansoni ap endonuclease 0.0042 0.0122 0.0122
Brugia malayi jmjC domain containing protein 0.0029 0.0063 0.0211
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0296 0.0997
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0058 0.0191 0.041
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0009 0.0001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0061 0.0205 0.0603
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0296 0.0939
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0207 0.2822
Toxoplasma gondii propionate-CoA ligase 0.0024 0.0042 0.0374
Loa Loa (eye worm) hypothetical protein 0.0035 0.0091 0.0306
Loa Loa (eye worm) beta-lactamase 0.0145 0.0573 0.1929
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.0042 0.0696
Mycobacterium ulcerans hypothetical protein 0.0117 0.0452 0.1515
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0142
Chlamydia trachomatis pyruvate kinase 0.0038 0.0102 0.1155
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0124 0.0481 0.8332
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0227 0.0227
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0037 0.0597
Mycobacterium tuberculosis Probable esterase LipL 0.0145 0.0573 0.1372
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0063 0.0211
Loa Loa (eye worm) hypothetical protein 0.0029 0.0063 0.0211
Loa Loa (eye worm) hypothetical protein 0.0152 0.0606 0.204
Giardia lamblia DINP protein human, muc B family 0.0109 0.0417 1
Mycobacterium tuberculosis Conserved protein 0.0145 0.0573 0.1372
Entamoeba histolytica acyl-coA synthetase, putative 0.0082 0.0296 0.7471
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0206 0.0693
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0063 0.0211
Mycobacterium leprae conserved hypothetical protein 0.0145 0.0573 0.1963
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0447 0.1503
Echinococcus multilocularis musashi 0.0027 0.0055 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.0516 0.792
Echinococcus granulosus dual specificity 0.0101 0.0379 0.0372
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0638 0.2748 1
Echinococcus multilocularis 0.0213 0.0876 0.0869
Echinococcus multilocularis leucyl aminopeptidase 0.0025 0.0045 0.0037
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0037 0.0272
Entamoeba histolytica hypothetical protein 0.0071 0.025 0.6139
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0024 0.042
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0025 0.0045 0.0037
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.0042 0.0696
Loa Loa (eye worm) histone methyltransferase 0.002 0.0027 0.009
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.0122 0.141
Schistosoma mansoni ap endonuclease 0.0042 0.0122 0.0122
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0024 0.0042 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0132 0.2267
Onchocerca volvulus 0.0098 0.0369 0.6442
Trypanosoma cruzi DNA damage repair protein, putative 0.0032 0.0076 0.0643
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0082 0.0296 0.0939
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0037 0.0029
Brugia malayi nuclear receptor NHR-88 0.002 0.0024 0.0081
Schistosoma mansoni cpg binding protein 0.007 0.0244 0.0244
Toxoplasma gondii histone lysine methyltransferase SET1 0.0125 0.0487 0.8442
Echinococcus multilocularis lysine specific demethylase 5A 0.0107 0.0409 0.0402
Onchocerca volvulus 0.0024 0.0042 0.0736
Toxoplasma gondii ABC1 family protein 0.0145 0.0573 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0101 0.0379 0.5664
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0094 0.0349 0.1175
Leishmania major acetyl-CoA synthetase, putative 0.0024 0.0042 0.0093
Entamoeba histolytica deoxycytidyl transferase, putative 0.0102 0.0384 1
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0285 0.4949
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0029 0.0063 0.0431
Echinococcus granulosus pyruvate kinase 0.0019 0.0022 0.0014
Onchocerca volvulus 0.002 0.0024 0.042
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0024 0.0024
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.0045 0.0142
Trypanosoma brucei pyruvate kinase 1 0.0038 0.0102 0.1083
Brugia malayi nuclear hormone receptor 0.002 0.0024 0.0081
Loa Loa (eye worm) hypothetical protein 0.0061 0.0206 0.0693
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0173 0.0583
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0029 0.0464
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0025 0.0045 0.0045
Mycobacterium ulcerans hypothetical protein 0.0145 0.0573 0.1963
Echinococcus multilocularis microtubule associated protein 2 0.2286 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0082 0.0296 0.0997
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0032 0.0079 0.0071
Echinococcus multilocularis chromobox protein 1 0.0079 0.0285 0.0277
Leishmania major DNA polymerase eta, putative 0.009 0.0333 0.4902
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0024 0.0081
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.025 0.0242
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0025 0.0045 0.0142
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0039 0.0108 0.1571
Echinococcus multilocularis chromobox protein 1 0.0079 0.0285 0.0277
Echinococcus multilocularis dna polymerase kappa 0.0132 0.0516 0.0508
Plasmodium vivax hypothetical protein, conserved 0.0089 0.0327 0.5539
Leishmania major DNA polymerase kappa, putative 0.0109 0.0417 0.6281
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0024 0.0016
Schistosoma mansoni lamin 0.0027 0.0055 0.0055
Entamoeba histolytica hypothetical protein 0.0071 0.025 0.6139
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0025 0.0045 0.0152
Schistosoma mansoni hypothetical protein 0.1291 0.5621 0.5621
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0053 0.0265
Loa Loa (eye worm) hypothetical protein 0.0044 0.0132 0.0444
Entamoeba histolytica protein kinase domain containing protein 0.0101 0.0379 0.9866
Echinococcus multilocularis dnaJ subfamily B 0.094 0.4076 0.4072
Brugia malayi jmjC domain containing protein 0.0029 0.0063 0.0211
Plasmodium vivax pyruvate kinase, putative 0.0038 0.0102 0.146
Schistosoma mansoni survival motor neuron protein 0.0098 0.0369 0.0369
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0132 0.2301
Schistosoma mansoni chromobox protein 0.0079 0.0285 0.0285
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0173 0.0165
Schistosoma mansoni tyrosine kinase 0.0367 0.155 0.155
Mycobacterium ulcerans pyruvate kinase 0.0038 0.0102 0.0222
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0102 0.0344
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0009 0.0001
Brugia malayi hypothetical protein 0.0071 0.025 0.0841
Entamoeba histolytica hypothetical protein 0.0026 0.0053 0.0462
Mycobacterium ulcerans hypothetical protein 0.0117 0.0452 0.1515
Echinococcus multilocularis epidermal growth factor receptor 0.0689 0.2972 0.2966
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0045 0.0137 0.0136
Schistosoma mansoni lamin 0.0027 0.0055 0.0055
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0198 0.081 0.2725
Brugia malayi follicle stimulating hormone receptor 0.0271 0.1132 0.3808
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0162 0.0546
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0042 0.0037
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0064 0.0774
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0145 0.0573 0.1372
Loa Loa (eye worm) RecQ helicase 0.0023 0.0037 0.0123
Brugia malayi CHD4 protein 0.0017 0.001 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0075 0.1268
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0055 0.0185
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.0122 0.0114
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0024 0.0016
Echinococcus granulosus survival motor neuron protein 1 0.0482 0.2058 0.2051
Loa Loa (eye worm) hypothetical protein 0.0082 0.0296 0.0997
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0027
Schistosoma mansoni protein phosphatase 2C 0.0029 0.0063 0.0063
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0025 0.0045 0.0152
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0024 0.0081
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0024 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0076 0.0643
Loa Loa (eye worm) hypothetical protein 0.0145 0.0573 0.1929
Schistosoma mansoni intermediate filament proteins 0.0027 0.0055 0.0055
Toxoplasma gondii ImpB/MucB/SamB family protein 0.009 0.0333 0.5651
Loa Loa (eye worm) TK/EGFR protein kinase 0.0689 0.2972 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0024 0.0081
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0024 0.0024
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0027 0.0019
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.001 0.0002
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0291 0.1216 0.1209
Leishmania major pyruvate kinase 0.0038 0.0102 0.1083
Mycobacterium tuberculosis Conserved hypothetical protein 0.0117 0.0452 0.1068
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0198 0.081 0.0803
Schistosoma mansoni DNA helicase recq5 0.0023 0.0037 0.0037
Trypanosoma cruzi DNA polymerase kappa, putative 0.0132 0.0516 0.792
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0024 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0024 0.0081
Loa Loa (eye worm) pyruvate kinase 0.0038 0.0102 0.0344
Trypanosoma brucei DNA polymerase eta, putative 0.016 0.0642 1
Brugia malayi MH2 domain containing protein 0.0116 0.0447 0.1503
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0042 0.0142
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0008 0.0027
Schistosoma mansoni hypothetical protein 0.0089 0.0327 0.0327
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0291 0.1216 0.1209
Echinococcus multilocularis leucine aminopeptidase protein 0.0124 0.0481 0.0474
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Leishmania major DNA polymerase kappa, putative 0.0032 0.0076 0.0643
Brugia malayi Heterochromatin protein 1 0.0079 0.0285 0.0959
Onchocerca volvulus 0.0082 0.0296 0.5166
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0029 0.0464
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0053 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0024 0.0081
Entamoeba histolytica protein kinase, putative 0.0101 0.0379 0.9866
Echinococcus granulosus PHD finger protein rhinoceros 0.0089 0.0327 0.0319
Brugia malayi beta-lactamase 0.0145 0.0573 0.1929
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0278 0.3987
Schistosoma mansoni pyruvate kinase 0.0019 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0081
Schistosoma mansoni hypothetical protein 0.094 0.4076 0.4076
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0124 0.0481 0.159
Trypanosoma cruzi DNA polymerase eta, putative 0.009 0.0333 0.4902
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0076 0.0977
Echinococcus granulosus lysine specific demethylase 6a 0.0029 0.0063 0.0055
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0053 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0198 0.081 0.0803
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.037 0.1567 0.1561
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0042 0.0142
Echinococcus granulosus jumonji domain containing protein 0.0123 0.048 0.0472
Loa Loa (eye worm) hypothetical protein 0.0094 0.0349 0.1175
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.006 0.0999
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.001 0.001
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0053 0.0265
Trypanosoma cruzi DNA polymerase kappa, putative 0.0132 0.0516 0.792
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0924 0.4004 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.0122 0.041
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0024 0.0042 0.0142
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0147 0.2527
Brugia malayi jmjC domain containing protein 0.0291 0.1216 0.4091
Onchocerca volvulus 0.0027 0.0055 0.0955
Echinococcus multilocularis jumonji domain containing 1A 0.0029 0.0063 0.0055
Plasmodium vivax hypothetical protein, conserved 0.0145 0.0573 1
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0082 0.1095
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0024 0.0042 0.0037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0024 0.0016
Loa Loa (eye worm) hypothetical protein 0.0061 0.0205 0.0691
Echinococcus granulosus FTZ F1 alpha 0.002 0.0024 0.0016
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0042 0.0093
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0145 0.0573 0.1372
Schistosoma mansoni cpg binding protein 0.007 0.0244 0.0244
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.006 0.0999
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0145 0.0573 0.1372
Schistosoma mansoni DNA polymerase IV / kappa 0.0032 0.0076 0.0075
Trichomonas vaginalis DNA polymerase eta, putative 0.0132 0.0516 0.8996
Brugia malayi polk-prov protein 0.0062 0.0207 0.0698
Schistosoma mansoni coup transcription factor 0.002 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.0071 0.025 0.6139
Trypanosoma brucei pyruvate kinase 1, putative 0.0038 0.0102 0.1083
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0102 0.0384 0.1292
Trypanosoma brucei unspecified product 0.0124 0.0483 0.7379
Brugia malayi Pyruvate kinase, muscle isozyme 0.0038 0.0102 0.0344
Plasmodium vivax DNA repair protein REV1, putative 0.0032 0.0076 0.0977
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0024 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0573 1
Onchocerca volvulus 0.0035 0.009 0.1565
Brugia malayi cytosol aminopeptidase 0.0025 0.0045 0.0152
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0102 0.1782
Schistosoma mansoni jumonji/arid domain-containing protein 0.0111 0.0426 0.0426
Entamoeba histolytica hypothetical protein 0.0101 0.0379 0.9866
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0042 0.0122 0.0237
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0369 0.1243
Brugia malayi AF-10 protein 0.0029 0.0064 0.0217
Mycobacterium ulcerans esterase/lipase LipP 0.0145 0.0573 0.1963
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0063 0.0431
Mycobacterium ulcerans DNA polymerase IV 0.0132 0.0516 0.1751
Schistosoma mansoni tyrosine kinase 0.022 0.0907 0.0907
Loa Loa (eye worm) hypothetical protein 0.0024 0.0042 0.0142
Schistosoma mansoni tyrosine kinase 0.0689 0.2972 0.2972
Trypanosoma cruzi pyruvate kinase 2, putative 0.0038 0.0102 0.1083
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0447 0.1503
Echinococcus granulosus lamin 0.0027 0.0055 0.0047
Echinococcus multilocularis beta LACTamase domain containing family member 0.0145 0.0573 0.0566
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0024 0.0081
Leishmania major hypothetical protein, conserved 0.0029 0.0063 0.0431
Loa Loa (eye worm) hypothetical protein 0.0027 0.0055 0.0185
Schistosoma mansoni hypothetical protein 0.0016 0.0008 0.0008
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0024 0.0042 0.0093
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0029 0.0064 0.0774
Entamoeba histolytica acyl-CoA synthetase, putative 0.0082 0.0296 0.7471
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0024 0.0024
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0009 0.0001
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0025 0.0045 0.0152
Echinococcus granulosus epidermal growth factor receptor 0.037 0.1567 0.1561
Brugia malayi TAR-binding protein 0.0066 0.0227 0.0765
Chlamydia trachomatis cytosol aminopeptidase 0.0124 0.0481 1
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0173 0.0173
Echinococcus multilocularis lamin 0.0027 0.0055 0.0047
Trichomonas vaginalis pyruvate kinase, putative 0.0038 0.0102 0.1746
Schistosoma mansoni tyrosine kinase 0.0367 0.155 0.155
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.0516 0.792
Echinococcus granulosus insulin receptor 0.022 0.0907 0.0899
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0278 0.3987
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0198 0.081 0.081
Mycobacterium tuberculosis Conserved protein 0.0145 0.0573 0.1372
Brugia malayi mbt repeat family protein 0.0054 0.0173 0.0583
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0038 0.0102 0.0188
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0227 0.022
Loa Loa (eye worm) hypothetical protein 0.0061 0.0205 0.0691
Trypanosoma brucei unspecified product 0.007 0.0245 0.3446
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0025 0.0045 0.0142
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0101 0.0379 0.1277
Loa Loa (eye worm) jmjC domain-containing protein 0.0183 0.0743 0.25
Echinococcus multilocularis phd:f box containing protein 0.0029 0.0063 0.0055
Echinococcus granulosus JmjC domain containing protein 4 0.0029 0.0063 0.0055
Echinococcus granulosus bloom syndrome protein 0.0023 0.0037 0.0029
Mycobacterium ulcerans beta-lactamase 0.0145 0.0573 0.1963
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0024 0.0081
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0042 0.0122 0.2456
Plasmodium falciparum M17 leucyl aminopeptidase 0.0124 0.0481 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0029 0.0063 0.0745
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0102 0.0384 0.0376
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0082 0.0296 0.0939
Trypanosoma brucei unspecified product 0.007 0.0245 0.3446
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0198 0.081 0.0803
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0024 0.0016
Brugia malayi jmjC domain containing protein 0.0111 0.0426 0.1433
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0147 0.256
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0053 0.0676
Toxoplasma gondii exonuclease III APE 0.0042 0.0122 0.1819
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0122 0.2092
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0024 0.0081
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0037 0.0326
Entamoeba histolytica protein kinase, putative 0.0101 0.0379 0.9866
Mycobacterium tuberculosis Conserved protein 0.0145 0.0573 0.1372
Schistosoma mansoni hypothetical protein 0.0016 0.0008 0.0008
Brugia malayi jmjC domain containing protein 0.0029 0.0063 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.0516 0.792
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0638 0.2748 0.6841
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0638 0.2748 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0102 0.0384 0.0384
Loa Loa (eye worm) hypothetical protein 0.0089 0.0327 0.1101
Schistosoma mansoni nuclear hormone receptor 0.002 0.0024 0.0024
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0037 0.0326
Echinococcus multilocularis pyruvate kinase 0.0019 0.0022 0.0014
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0024 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.006 0.0999
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0091 0.0306
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0024 0.0081
Echinococcus granulosus lysine specific demethylase 5A 0.0111 0.0426 0.0418
Loa Loa (eye worm) hypothetical protein 0.0062 0.0207 0.0698
Echinococcus multilocularis dual specificity 0.0101 0.0379 0.0372
Mycobacterium tuberculosis Probable lipase LipE 0.0145 0.0573 0.1372
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0076 0.0643
Schistosoma mansoni pyruvate kinase 0.0038 0.0102 0.0102
Onchocerca volvulus 0.0024 0.0042 0.0736
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0032 0.0079 0.0071
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0053 0.0563
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0573 0.8866
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0042 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0145 0.0573 0.1929
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0082 0.0296 0.0939
Trypanosoma brucei DNA damage repair protein, putative 0.0032 0.0076 0.0643
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0027 0.0019
Brugia malayi intermediate filament protein 0.0027 0.0055 0.0185
Schistosoma mansoni jumonji/arid domain-containing protein 0.0111 0.0426 0.0426
Onchocerca volvulus Pyruvate kinase homolog 0.0038 0.0102 0.1782
Schistosoma mansoni jumonji domain containing protein 0.0029 0.0063 0.0063
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0029 0.0063 0.0745
Echinococcus multilocularis geminin 0.1291 0.5621 0.5618
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0024 0.0081
Mycobacterium ulcerans hypothetical protein 0.0082 0.0296 0.0939
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0082 0.0296 0.0676
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.0122 0.1734
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.0516 0.792
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0024 0.0042 0.0093
Plasmodium falciparum pyruvate kinase 0.0038 0.0102 0.1752
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0122 0.2092
Onchocerca volvulus Alhambra homolog 0.0089 0.0327 0.5707
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0162 0.0546
Echinococcus granulosus dna polymerase kappa 0.0132 0.0516 0.0508
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.0063 0.0894
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.006 0.0999
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0024 0.0081
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0227 0.0765
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.0573 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0008 0.0027
Echinococcus granulosus dna polymerase eta 0.016 0.0642 0.0634
Echinococcus multilocularis JmjC domain containing protein 4 0.0029 0.0063 0.0055
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0124 0.0481 0.7346
Mycobacterium leprae Probable pyruvate kinase PykA 0.0038 0.0102 0.0222
Trypanosoma brucei hypothetical protein, conserved 0.0145 0.0573 0.8866
Schistosoma mansoni tyrosine kinase 0.0367 0.155 0.155
Echinococcus granulosus lamin dm0 0.0027 0.0055 0.0047
Schistosoma mansoni acetyl-CoA synthetase 0.0024 0.0042 0.0042
Entamoeba histolytica acyl-CoA synthetase, putative 0.0082 0.0296 0.7471
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.0573 0.0573
Brugia malayi Protein kinase domain containing protein 0.022 0.0907 0.3051
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0206 0.0198
Echinococcus granulosus beta LACTamase domain containing family member 0.0145 0.0573 0.0566
Leishmania major hypothetical protein, conserved 0.0145 0.0573 0.8866
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0024 0.0081
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0123
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0122 0.1819
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0024 0.0024
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0076 0.0643
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0025 0.0045 0.0142
Echinococcus granulosus leucyl aminopeptidase 0.0025 0.0045 0.0037
Mycobacterium leprae Probable lipase LipE 0.0145 0.0573 0.1963
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0024 0.0042 0.0374
Onchocerca volvulus 0.0024 0.0042 0.0736
Plasmodium vivax acyl-CoA synthetase, putative 0.0061 0.0205 0.333
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0037 0.0029
Loa Loa (eye worm) jmjC domain-containing protein 0.0111 0.0426 0.1433
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0573 1
Brugia malayi beta-lactamase family protein 0.0145 0.0573 0.1929
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.0516 0.792
Brugia malayi F/Y-rich N-terminus family protein 0.0049 0.0153 0.0515
Toxoplasma gondii PHD-finger domain-containing protein 0.0089 0.0327 0.5539
Brugia malayi Pyruvate kinase, M2 isozyme 0.0038 0.0102 0.0344
Onchocerca volvulus 0.0145 0.0573 1
Brugia malayi ImpB/MucB/SamB family protein 0.0102 0.0384 0.1292
Trypanosoma brucei DNA polymerase kappa, putative 0.0132 0.0516 0.792
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0024 0.0016
Schistosoma mansoni DNA helicase recq1 0.0023 0.0037 0.0037
Trypanosoma cruzi DNA polymerase eta, putative 0.016 0.0642 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0173 0.0165
Mycobacterium ulcerans acyl-CoA synthetase 0.0082 0.0296 0.0939
Echinococcus granulosus pyruvate kinase 0.0019 0.0022 0.0014
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0042 0.0142
Echinococcus multilocularis pyruvate kinase 0.003 0.0067 0.0059
Echinococcus granulosus chromobox protein 1 0.0079 0.0285 0.0277
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.0573 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.