TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 424.408 | Formula: C19H27N3O6P-
H donors: 4 H acceptors: 5 LogP: 1.59 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: CCOP(=O)(N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)CC(C)C)[O-]
InChi: 1S/C19H28N3O6P/c1-4-28-29(26,27)22-16(9-12(2)3)18(23)21-17(19(24)25)10-13-11-20-15-8-6-5-7-14(13)15/h5-8,11-12,16-17,20H,4,9-10H2,1-3H3,(H,21,23)(H,24,25)(H2,22,26,27)/p-1/t16-,17-/m0/s1
InChiKey: BTNRHCBRXWWVAK-IRXDYDNUSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0024	0.0226	0.0117
Plasmodium falciparum	nitric oxide synthase, putative	0.0406	1	1
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0106	0.0106
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0022	0.0165	0.0055
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0696	0.0653
Echinococcus multilocularis	partitioning defective 3	0.002	0.0106	0.0106
Echinococcus granulosus	membrane associated guanylate kinase, WW and PDZ	0.002	0.0106	0.0106
Echinococcus multilocularis	Partitioning defective 3 protein B	0.002	0.0106	0.0106
Loa Loa (eye worm)	PAR-6 protein	0.002	0.0106	0.0106
Entamoeba histolytica	hypothetical protein	0.0024	0.0226	0.0631
Echinococcus multilocularis	membrane associated guanylate kinase, WW and PDZ	0.002	0.0106	0.0106
Echinococcus granulosus	adam 17 protease	0.0018	0.0073	0.0073
Trypanosoma cruzi	p450 reductase, putative	0.0406	1	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Echinococcus granulosus	membrane associated guanylate kinase ww and pdz	0.002	0.0106	0.0106
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0046	0.0787	0.0745
Trypanosoma brucei	hypothetical protein, conserved	0.0024	0.0226	0.0182
Plasmodium falciparum	NADPH--cytochrome P450 reductase, putative	0.0155	0.3581	0.351
Brugia malayi	PDZ domain containing protein	0.002	0.0106	0.0106
Echinococcus granulosus	55 kDa erythrocyte membrane protein	0.002	0.0106	0.0106
Brugia malayi	hypothetical protein	0.002	0.0106	0.0106
Brugia malayi	abnormal cell lineage protein 10 (Protein lin-10), putative	0.002	0.0106	0.0106
Echinococcus granulosus	beta 1 syntrophin	0.002	0.0106	0.0106
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.002	0.0106	0.0106
Mycobacterium tuberculosis	Hypothetical oxidoreductase	0.0046	0.0787	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0833	0.0833
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0833	0.0833
Brugia malayi	hypothetical protein	0.002	0.0106	0.0106
Loa Loa (eye worm)	gopc protein	0.002	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Brugia malayi	rho guanine nucleotide exchange factor 12	0.002	0.0106	0.0106
Onchocerca volvulus		0.002	0.0106	0.0587
Brugia malayi	syntenin	0.002	0.0106	0.0106
Schistosoma mansoni	syntenin	0.002	0.0106	0.0106
Schistosoma mansoni	ap endonuclease	0.002	0.011	0.011
Chlamydia trachomatis	sulfite reductase	0.0251	0.6024	1
Loa Loa (eye worm)	X11 protein	0.002	0.0106	0.0106
Echinococcus multilocularis	SH3 and multiple ankyrin repeat domains protein	0.002	0.0106	0.0106
Brugia malayi	FAD binding domain containing protein	0.0406	1	1
Echinococcus granulosus	syndecan binding protein syntenin	0.002	0.0106	0.0106
Echinococcus granulosus	glutamate receptor interacting protein 1	0.002	0.0106	0.0106
Brugia malayi	hypothetical protein	0.002	0.0106	0.0106
Echinococcus multilocularis	protein piccolo	0.002	0.0106	0.0106
Brugia malayi	FAD binding domain containing protein	0.0251	0.6024	0.6024
Leishmania major	cytochrome-b5 reductase, putative	0.0046	0.0787	0.0684
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0696	0.0653
Echinococcus granulosus	MAGUK p55 subfamily	0.002	0.0106	0.0106
Schistosoma mansoni	syntrophin	0.002	0.0106	0.0106
Onchocerca volvulus		0.002	0.0106	0.0587
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0155	0.3581	0.351
Leishmania major	nitrate reductase, putative	0.0046	0.0787	0.0684
Brugia malayi	hypothetical protein	0.002	0.0106	0.0106
Brugia malayi	Syntrophin-1	0.002	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Echinococcus granulosus	subfamily M12B unassigned peptidase	0.0044	0.0734	0.0734
Schistosoma mansoni	hypothetical protein	0.002	0.0106	0.0106
Brugia malayi	Guanylate kinase family protein	0.002	0.0106	0.0106
Loa Loa (eye worm)	PDZ-domain-containing protein scribble	0.002	0.0106	0.0106
Schistosoma mansoni	cytochrome B5	0.0046	0.0787	0.0787
Brugia malayi	diaphorase	0.0046	0.0787	0.0787
Brugia malayi	flavodoxin family protein	0.0155	0.3581	0.3581
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Echinococcus granulosus	adam	0.0058	0.1082	0.1082
Schistosoma mansoni	multiple pdz domain protein	0.002	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Onchocerca volvulus	Arc homolog	0.002	0.0106	0.0587
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0046	0.0787	0.0684
Leishmania major	phosphopantetheinyl transferase-like protein	0.0024	0.0226	0.0117
Echinococcus granulosus	MAGUK p55 subfamily	0.002	0.0106	0.0106
Mycobacterium ulcerans	DNA polymerase IV	0.0043	0.0696	0.0592
Schistosoma mansoni	dishevelled	0.002	0.0106	0.0106
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0024	0.0226	0.025
Echinococcus granulosus	Rho GTPase activating protein 21	0.002	0.0106	0.0106
Echinococcus multilocularis	myeloid:lymphoid or mixed lineage leukemia	0.002	0.0106	0.0106
Echinococcus multilocularis	protein lin 7 B	0.002	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Giardia lamblia	Hypothetical protein	0.036	0.8818	1
Toxoplasma gondii	NADH-cytochrome b5 reductase 1, putative	0.0046	0.0787	0.1455
Echinococcus multilocularis	amyloid beta A4 protein	0.002	0.0106	0.0106
Leishmania major	NADH-dependent fumarate reductase-like protein	0.0046	0.0787	0.0684
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0024	0.0226	0.0202
Echinococcus granulosus	NADH cytochrome b5 reductase 3	0.0046	0.0787	0.0787
Trypanosoma brucei	DNA polymerase IV, putative	0.0043	0.0696	0.0653
Loa Loa (eye worm)	syntrophin-1	0.002	0.0106	0.0106
Echinococcus granulosus	segment polarity protein dishevelled	0.002	0.0106	0.0106
Echinococcus multilocularis	cytochrome b5 reductase 4	0.0046	0.0787	0.0787
Schistosoma mansoni	membrane associated guanylate kinase inverted related	0.002	0.0106	0.0106
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0155	0.3581	0.351
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0696	0.0653
Echinococcus multilocularis	PDZ and LIM domain protein Zasp	0.002	0.0106	0.0106
Trypanosoma brucei	NADH-dependent fumarate reductase	0.0046	0.0787	0.0745
Toxoplasma gondii	flavodoxin domain-containing protein	0.0201	0.4763	1
Schistosoma mansoni	multiple pdz domain protein	0.002	0.0106	0.0106
Schistosoma mansoni	MAGUK homolog	0.002	0.0106	0.0106
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0251	0.6024	0.6024
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0022	0.0165	0.0809
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0043	0.0696	0.0592
Schistosoma mansoni	NADPH flavin oxidoreductase	0.0204	0.4842	0.4842
Loa Loa (eye worm)	PX domain-containing protein	0.002	0.0106	0.0106
Trypanosoma brucei	DNA polymerase IV, putative	0.0036	0.0521	0.0477
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0046	0.0787	0.0745
Echinococcus multilocularis	segment polarity protein dishevelled	0.002	0.0106	0.0106
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0406	1	1
Echinococcus granulosus	rho guanine nucleotide exchange factor 12	0.002	0.0106	0.0106
Mycobacterium ulcerans	flavodoxin oxidoreductase	0.0046	0.0787	0.0684
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Schistosoma mansoni	protein kinase C alpha binding protein	0.002	0.0106	0.0106
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.011	0.011
Trypanosoma cruzi	reductase, putative	0.0046	0.0787	0.0684
Schistosoma mansoni	leucine-rich repeat protein	0.002	0.0106	0.0106
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0833	0.0833
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0086	0.1813	0.1813
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Onchocerca volvulus		0.002	0.0106	0.0587
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0046	0.0787	0.0684
Brugia malayi	9ORF binding protein 1	0.002	0.0106	0.0106
Echinococcus granulosus	peripheral plasma membrane protein CASK	0.002	0.0106	0.0106
Schistosoma mansoni	hypothetical protein	0.002	0.0106	0.0106
Echinococcus multilocularis	MAGUK p55 subfamily	0.002	0.0106	0.0106
Echinococcus multilocularis	MAGUK p55 subfamily	0.002	0.0106	0.0106
Schistosoma mansoni	Patj homolog	0.002	0.0106	0.0106
Schistosoma mansoni	hypothetical protein	0.002	0.0106	0.0106
Loa Loa (eye worm)	guanylate kinase	0.002	0.0106	0.0106
Echinococcus granulosus	amyloid beta A4 protein	0.002	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0046	0.0787	0.0684
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0155	0.3581	0.351
Schistosoma mansoni	NADH-cytochrome B5 reductase	0.0046	0.0787	0.0787
Echinococcus granulosus	cytochrome b5 reductase 4	0.0046	0.0787	0.0787
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Echinococcus granulosus	SH3 and multiple ankyrin repeat domains protein	0.002	0.0106	0.0106
Mycobacterium ulcerans	flavodoxin reductase Hmp	0.0046	0.0787	0.0684
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.002	0.0106	0.0106
Onchocerca volvulus	Big bang homolog	0.002	0.0106	0.0587
Brugia malayi	polk-prov protein	0.0032	0.0431	0.0431
Trypanosoma cruzi	nitrate reductase, putative	0.0046	0.0787	0.0684
Trypanosoma brucei	oxidoreductase-protein, putative	0.0046	0.0787	0.0745
Schistosoma mansoni	adam (A disintegrin and metalloprotease	0.0058	0.1082	0.1082
Echinococcus multilocularis	glutamate receptor interacting protein 1	0.002	0.0106	0.0106
Echinococcus multilocularis	pdz domain containing protein	0.002	0.0106	0.0106
Schistosoma mansoni	subfamily M12B unassigned peptidase (M12 family)	0.0044	0.0734	0.0734
Schistosoma mansoni	hypothetical protein	0.002	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Leishmania major	p450 reductase, putative	0.0406	1	1
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.011	0.011
Schistosoma mansoni	maguk P55 subfamily member 26	0.002	0.0106	0.0106
Brugia malayi	hypothetical protein	0.002	0.0106	0.0106
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0406	1	1
Onchocerca volvulus		0.002	0.0106	0.0587
Brugia malayi	PDZ domain containing protein	0.002	0.0106	0.0106
Plasmodium vivax	ferredoxin--NADP reductase, putative	0.0046	0.0787	0.0684
Brugia malayi	Neurabin protein 1	0.002	0.0106	0.0106
Schistosoma mansoni	afadin (af-6 protein)	0.002	0.0106	0.0106
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0833	0.0833
Brugia malayi	cell junction protein LIN-7	0.002	0.0106	0.0106
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0833	0.0833
Brugia malayi	Partitioning defective-6 homolog alpha	0.002	0.0106	0.0106
Echinococcus granulosus	MAGUK p55 subfamily	0.002	0.0106	0.0106
Brugia malayi	Disintegrin family protein	0.0018	0.0073	0.0073
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.002	0.0106	0.0587
Schistosoma mansoni	hypothetical protein	0.002	0.0106	0.0106
Schistosoma mansoni	sh3 and multiple ankyrin repeat domains protein 12 (shank12)	0.002	0.0106	0.0106
Echinococcus multilocularis	rho guanine nucleotide exchange factor 12	0.002	0.0106	0.0106
Schistosoma mansoni	leucine-rich repeat protein	0.002	0.0106	0.0106
Onchocerca volvulus		0.002	0.0106	0.0587
Schistosoma mansoni	discs lost-related	0.002	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Giardia lamblia	Flavohemoprotein lateral transfer candidate	0.0046	0.0787	0.0777
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0086	0.1813	0.1813
Echinococcus multilocularis	SH3 and multiple ankyrin repeat domains protein	0.002	0.0106	0.0106
Echinococcus multilocularis	membrane associated guanylate kinase ww and pdz	0.002	0.0106	0.0106
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.0406	1	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0406	1	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Leishmania major	cytochrome-b5 reductase, putative	0.0046	0.0787	0.0684
Brugia malayi	ADAM-TS Spacer 1 family protein	0.0026	0.0265	0.0265
Onchocerca volvulus		0.002	0.0106	0.0587
Trypanosoma brucei	NADH-dependent fumarate reductase, putative	0.0046	0.0787	0.0745
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Echinococcus granulosus	PRKCA binding protein	0.002	0.0106	0.0106
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0046	0.0787	0.0745
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.011	0.0307
Mycobacterium tuberculosis	Possible electron transfer protein FdxB	0.0046	0.0787	1
Loa Loa (eye worm)	flavodoxin family protein	0.0155	0.3581	0.3581
Loa Loa (eye worm)	reprolysin	0.0044	0.0734	0.0734
Brugia malayi	PX domain containing protein	0.002	0.0106	0.0106
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.0406	1	1
Schistosoma mansoni	MAGUK homolog	0.002	0.0106	0.0106
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.002	0.0106	0.0106
Entamoeba histolytica	type A flavoprotein, putative	0.0155	0.3581	1
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.0406	1	1
Echinococcus granulosus	Partitioning defective 3 protein B	0.002	0.0106	0.0106
Schistosoma mansoni	rab3 interacting molecule (rim)-related	0.002	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Chlamydia trachomatis	Na(+)-translocating NADH-quinone reductase subunit F	0.0046	0.0787	0.115
Leishmania major	DNA polymerase kappa, putative	0.0022	0.0165	0.0055
Mycobacterium ulcerans	electron transfer protein FdxB	0.0046	0.0787	0.0684
Plasmodium vivax	flavodoxin domain containing protein	0.036	0.8818	0.8805
Echinococcus granulosus	PDZ and LIM domain protein Zasp	0.002	0.0106	0.0106
Onchocerca volvulus		0.002	0.0106	0.0587
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0046	0.0787	0.0684
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.0406	1	1
Brugia malayi	PDZ domain	0.002	0.0106	0.0106
Mycobacterium tuberculosis	Probable monooxygenase	0.0046	0.0787	1
Echinococcus multilocularis	55 kDa erythrocyte membrane protein	0.002	0.0106	0.0106
Loa Loa (eye worm)	AGC/MAST/MAST protein kinase	0.002	0.0106	0.0106
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0043	0.0696	0.0592
Entamoeba histolytica	type A flavoprotein, putative	0.0155	0.3581	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Schistosoma mansoni	dishevelled	0.002	0.0106	0.0106
Brugia malayi	hypothetical protein	0.0058	0.1082	0.1082
Schistosoma mansoni	multiple pdz domain protein	0.002	0.0106	0.0106
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0024	0.0226	0.1717
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0046	0.0787	0.0684
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0833	0.0833
Schistosoma mansoni	lin-7-like proteins	0.002	0.0106	0.0106
Brugia malayi	PDZ domain	0.002	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Echinococcus granulosus	dna polymerase kappa	0.0043	0.0696	0.0696
Loa Loa (eye worm)	PDZ domain-containing protein	0.002	0.0106	0.0106
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0696	0.0653
Echinococcus multilocularis	ligand of numb protein x 2	0.002	0.0106	0.0106
Echinococcus granulosus	multiple pdz domain protein	0.002	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0265	0.0265
Loa Loa (eye worm)	cytochrome b5 reductase 4	0.0046	0.0787	0.0787
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.002	0.0106	0.0106
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0165	0.012
Echinococcus granulosus	cell polarity protein	0.002	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Entamoeba histolytica	type A flavoprotein, putative	0.0155	0.3581	1
Brugia malayi	Hypothetical 13.5 kDa protein C45G9.7 in chromosome III	0.002	0.0106	0.0106
Onchocerca volvulus		0.0046	0.0787	0.4339
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0833	0.0833
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0043	0.0696	0.0592
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.002	0.0106	0.0106
Echinococcus granulosus	3'partial\|membrane associated guanylate kinase ww and pdz	0.002	0.0106	0.0106
Schistosoma mansoni	cell polarity protein	0.002	0.0106	0.0106
Schistosoma mansoni	hypothetical protein	0.002	0.0106	0.0106
Echinococcus multilocularis	multiple pdz domain protein	0.002	0.0106	0.0106
Echinococcus multilocularis	NADH cytochrome b5 reductase 3	0.0046	0.0787	0.0787
Brugia malayi	ADAMTS-like protease	0.0026	0.0265	0.0265
Schistosoma mansoni	pdz domain containing protein	0.002	0.0106	0.0106
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0696	0.0653
Schistosoma mansoni	cell polarity protein	0.002	0.0106	0.0106
Echinococcus multilocularis	disintegrin and metalloproteinase	0.0018	0.0073	0.0073
Echinococcus multilocularis	Na(+):H(+) exchange regulatory cofactor NHE RF2	0.002	0.0106	0.0106
Trichomonas vaginalis	sulfite reductase, putative	0.0406	1	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0046	0.0787	1
Loa Loa (eye worm)	DIX domain-containing protein	0.002	0.0106	0.0106
Echinococcus multilocularis	peripheral plasma membrane protein CASK	0.002	0.0106	0.0106
Schistosoma mansoni	cytochrome P450 reductase	0.0406	1	1
Brugia malayi	gopc protein	0.002	0.0106	0.0106
Brugia malayi	hypothetical protein	0.002	0.0106	0.0106
Echinococcus granulosus	neurabin 1	0.002	0.0106	0.0106
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0155	0.3581	0.351
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0046	0.0787	0.0684
Schistosoma mansoni	ap endonuclease	0.002	0.011	0.011
Brugia malayi	Abnormal embryonic partitioning of cytoplasm protein 3	0.002	0.0106	0.0106
Echinococcus granulosus	partitioning defective 3	0.002	0.0106	0.0106
Echinococcus multilocularis	tight junction protein ZO 3	0.002	0.0106	0.0106
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0833	0.0833
Echinococcus multilocularis	beta 1 syntrophin	0.002	0.0106	0.0106
Echinococcus granulosus	multiple pdz domain protein	0.002	0.0106	0.0106
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.0406	1	1
Trichomonas vaginalis	NADPH fad oxidoreductase, putative	0.036	0.8818	0.8805
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0046	0.0787	0.0684
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0046	0.0787	0.0684
Schistosoma mansoni	membrane associated guanylate kinase inverted related	0.002	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0265	0.0265
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0833	0.0833
Schistosoma mansoni	5-methyl tetrahydrofolate-homocysteine methyltransferase reductase	0.0251	0.6024	0.6024
Echinococcus granulosus	segment polarity protein dishevelled	0.002	0.0106	0.0106
Schistosoma mansoni	hypothetical protein	0.002	0.0106	0.0106
Loa Loa (eye worm)	RasGEF domain-containing protein	0.002	0.0106	0.0106
Brugia malayi	Patj homolog	0.002	0.0106	0.0106
Giardia lamblia	Nitric oxide synthase, inducible	0.036	0.8818	1
Mycobacterium tuberculosis	Possible oxygenase	0.0046	0.0787	1
Echinococcus multilocularis	multiple pdz domain protein	0.002	0.0106	0.0106
Schistosoma mansoni	tight junction protein	0.002	0.0106	0.0106
Echinococcus granulosus	methionine synthase reductase	0.0251	0.6024	0.6024
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Schistosoma mansoni	PDZ domain protein	0.002	0.0106	0.0106
Schistosoma mansoni	pdz domain containing protein	0.002	0.0106	0.0106
Echinococcus multilocularis	multiple pdz domain protein	0.002	0.0106	0.0106
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0406	1	1
Echinococcus granulosus	partitioning defective 3	0.002	0.0106	0.0106
Echinococcus granulosus	cytochrome b5 reductase 4	0.0046	0.0787	0.0787
Schistosoma mansoni	maguk P55 subfamily member 35	0.002	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Brugia malayi	Synapse defective protein 1	0.002	0.0106	0.0106
Schistosoma mansoni	hypothetical protein	0.002	0.0106	0.0106
Plasmodium vivax	oxidoreductase NAD-binding domain containing protein	0.0046	0.0787	0.0684
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0696	0.0653
Trypanosoma brucei	NADH-dependent fumarate reductase	0.0046	0.0787	0.0745
Echinococcus multilocularis	SH3 and multiple ankyrin repeat domains protein	0.002	0.0106	0.0106
Brugia malayi	Guanylate kinase family protein	0.002	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Echinococcus granulosus	protein lin 7 B	0.002	0.0106	0.0106
Loa Loa (eye worm)	peripheral plasma membrane protein CASK	0.002	0.0106	0.0106
Trypanosoma brucei	DNA polymerase kappa, putative	0.0032	0.0431	0.0387
Trypanosoma brucei	NADH-dependent fumarate reductase, putative	0.0046	0.0787	0.0745
Mycobacterium ulcerans	oxygenase	0.0046	0.0787	0.0684
Brugia malayi	PDZ domain containing protein	0.002	0.0106	0.0106
Echinococcus multilocularis	partitioning defective protein 6	0.002	0.0106	0.0106
Schistosoma mansoni	cell polarity protein	0.002	0.0106	0.0106
Echinococcus multilocularis	subfamily M12B unassigned peptidase	0.0044	0.0734	0.0734
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0046	0.0787	0.0684
Trypanosoma cruzi	Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative	0.0155	0.3581	0.351
Echinococcus granulosus	pdz domain containing protein	0.002	0.0106	0.0106
Entamoeba histolytica	type A flavoprotein, putative	0.0155	0.3581	1
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0046	0.0787	0.0745
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0431	0.0431
Echinococcus granulosus	membrane associated guanylate kinase ww and pdz	0.002	0.0106	0.0106
Echinococcus multilocularis	neurabin 1	0.002	0.0106	0.0106
Brugia malayi	C2 domain containing protein	0.002	0.0106	0.0106
Echinococcus multilocularis	PDZ domain containing protein GIPC3	0.002	0.0106	0.0106
Echinococcus granulosus	SH3 and multiple ankyrin repeat domains protein	0.002	0.0106	0.0106
Onchocerca volvulus		0.0086	0.1813	1
Schistosoma mansoni	diflavin oxidoreductase	0.0201	0.4763	0.4763
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0734	0.0734
Trypanosoma cruzi	oxidoreductase-protein, putative	0.0046	0.0787	0.0684
Echinococcus multilocularis	pdz domain containing protein	0.002	0.0106	0.0106
Echinococcus multilocularis	Blood coagulation inhibitor, Disintegrin	0.0018	0.0073	0.0073
Treponema pallidum	flavodoxin	0.0155	0.3581	1
Schistosoma mansoni	hypothetical protein	0.002	0.0106	0.0106
Echinococcus multilocularis	pdz domain containing protein	0.002	0.0106	0.0106
Leishmania major	reductase, putative	0.0046	0.0787	0.0684
Brugia malayi	angiogenesis inhibito	0.0026	0.0265	0.0265
Plasmodium falciparum	NADH-cytochrome b5 reductase, putative	0.0046	0.0787	0.0684
Trypanosoma brucei	nitrate reductase, putative	0.0046	0.0787	0.0745
Echinococcus granulosus	multiple pdz domain protein	0.002	0.0106	0.0106
Echinococcus multilocularis	microtubule associated serine:threonine protein	0.002	0.0106	0.0106
Brugia malayi	PDZ-domain protein scribble	0.002	0.0106	0.0106
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0024	0.0226	0.0335
Echinococcus granulosus	tight junction protein ZO 3	0.002	0.0106	0.0106
Schistosoma mansoni	discs large	0.002	0.0106	0.0106
Echinococcus multilocularis	adam	0.0058	0.1082	0.1082
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.0406	1	1
Trypanosoma cruzi	cytochrome-b5 reductase, putative	0.0046	0.0787	0.0684
Trypanosoma brucei	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0155	0.3581	0.3552
Toxoplasma gondii	ferredoxin NADP+ oxidoreductase FNR	0.0046	0.0787	0.1455
Trypanosoma cruzi	NADPH--cytochrome P450 reductase, putative	0.0155	0.3581	0.351
Echinococcus multilocularis	PRKCA binding protein	0.002	0.0106	0.0106
Echinococcus granulosus	ligand of numb protein x 2	0.002	0.0106	0.0106
Echinococcus multilocularis	disks large 1	0.002	0.0106	0.0106
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.002	0.0106	0.0106
Schistosoma mansoni	ATP-dependent RNA Helicase	0.002	0.0106	0.0106
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0046	0.0787	0.0684
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Trypanosoma cruzi	cytochrome-b5 reductase, putative	0.0046	0.0787	0.0684
Echinococcus multilocularis		0.002	0.0106	0.0106
Loa Loa (eye worm)	diaphorase	0.0046	0.0787	0.0787
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0046	0.0787	0.0684
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0406	1	1
Mycobacterium ulcerans	oxidoreductase	0.0046	0.0787	0.0684
Treponema pallidum	ferredoxin-NADP(+) reductase subunit alpha	0.0046	0.0787	0.195
Schistosoma mansoni	multiple pdz domain protein	0.002	0.0106	0.0106
Mycobacterium ulcerans	monooxygenase	0.0046	0.0787	0.0684
Mycobacterium leprae	conserved hypothetical protein	0.0024	0.0226	0.5
Schistosoma mansoni	hypothetical protein	0.002	0.0106	0.0106
Leishmania major	hypothetical protein, conserved	0.0155	0.3581	0.351
Leishmania major	NADH-cytochrome b5 reductase, putative	0.0046	0.0787	0.0684
Trichomonas vaginalis	NADPH cytochrome P450, putative	0.0155	0.3581	0.351
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0024	0.0226	0.0117
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0696	0.0653
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0046	0.0787	0.0745
Echinococcus multilocularis	dna polymerase kappa	0.0043	0.0696	0.0696
Trypanosoma cruzi	NADH-dependent fumarate reductase, putative	0.0046	0.0787	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0073	0.0073
Schistosoma mansoni	hypothetical protein	0.002	0.0106	0.0106
Brugia malayi	Peripheral plasma membrane protein CASK	0.002	0.0106	0.0106
Schistosoma mansoni	pdz and lim domain protein	0.002	0.0106	0.0106
Entamoeba histolytica	type A flavoprotein, putative	0.0155	0.3581	1
Echinococcus multilocularis	PDZ and LIM domain protein Zasp	0.002	0.0106	0.0106
Echinococcus granulosus	pdz domain containing protein	0.002	0.0106	0.0106
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.0406	1	1
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0046	0.0787	0.0684
Plasmodium vivax	hypothetical protein, conserved	0.0155	0.3581	0.351
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0046	0.0787	0.0684
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0024	0.0226	0.025
Brugia malayi	RasGEF domain containing protein	0.002	0.0106	0.0106
Echinococcus granulosus	Blood coagulation inhibitor Disintegrin	0.0018	0.0073	0.0073
Echinococcus granulosus	PDZ and LIM domain protein Zasp	0.002	0.0106	0.0106
Brugia malayi	Ferm domain	0.002	0.0106	0.0106
Echinococcus granulosus	myeloid:lymphoid or mixed lineage leukemia	0.002	0.0106	0.0106
Schistosoma mansoni	lim domain	0.002	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.0406	1	1
Schistosoma mansoni	subfamily M12B unassigned peptidase (M12 family)	0.0044	0.0734	0.0734
Trypanosoma brucei	NADH-cytochrome b5 reductase, putative	0.0046	0.0787	0.0745
Trypanosoma brucei	NADH-cytochrome b5 reductase-like protein	0.0046	0.0787	0.0745
Echinococcus granulosus	disintegrin and metalloproteinase	0.0018	0.0073	0.0073
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.011	0.011
Trypanosoma brucei	DNA polymerase IV, putative	0.0043	0.0696	0.0653
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0086	0.1813	0.1813
Plasmodium falciparum	ferredoxin--NADP reductase	0.0046	0.0787	0.0684
Brugia malayi	microtubule-associated serine/threonine protein kinase 2 (MAST2)	0.002	0.0106	0.0106
Trichomonas vaginalis	DNA polymerase eta, putative	0.0043	0.0696	0.0592
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0696	0.0653
Echinococcus multilocularis	cell polarity protein leucine rich repeat	0.002	0.0106	0.0106
Mycobacterium ulcerans	formate dehydrogenase H FdhF	0.0406	1	1
Echinococcus multilocularis	methionine synthase reductase	0.0251	0.6024	0.6024
Echinococcus multilocularis	Rho GTPase activating protein 21	0.002	0.0106	0.0106
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0696	0.0653
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.0406	1	1
Echinococcus multilocularis	disks large 3	0.002	0.0106	0.0106
Echinococcus granulosus	pdz domain containing protein	0.002	0.0106	0.0106
Echinococcus granulosus	Microtubule-associated serine/threonine-protein kinase	0.002	0.0106	0.0106
Echinococcus multilocularis	syndecan binding protein (syntenin)	0.002	0.0106	0.0106
Trypanosoma cruzi	p450 reductase, putative	0.0046	0.0787	0.0684
Trypanosoma brucei	DNA polymerase kappa, putative	0.0032	0.0431	0.0387
Echinococcus granulosus	pdz domain containing protein	0.002	0.0106	0.0106
Echinococcus multilocularis	partitioning defective 3	0.002	0.0106	0.0106
Onchocerca volvulus		0.002	0.0106	0.0587
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0406	1	1
Schistosoma mansoni	membrane associated guanylate kinase inverted related	0.002	0.0106	0.0106
Loa Loa (eye worm)	cell junction protein LIN-7	0.002	0.0106	0.0106
Plasmodium falciparum	S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative	0.0155	0.3581	0.351
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0043	0.0696	0.0592
Onchocerca volvulus		0.002	0.0106	0.0587
Brugia malayi	Protein-tyrosine phosphatase 1	0.002	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Onchocerca volvulus		0.002	0.0106	0.0587
Schistosoma mansoni	hypothetical protein	0.002	0.0106	0.0106
Echinococcus granulosus	SH3 and multiple ankyrin repeat domains protein	0.002	0.0106	0.0106
Trypanosoma cruzi	NADH-cytochrome b5 reductase, putative	0.0046	0.0787	0.0684
Brugia malayi	DIX domain containing protein	0.002	0.0106	0.0106
Brugia malayi	Shank2E	0.002	0.0106	0.0106
Loa Loa (eye worm)	guanylate kinase	0.002	0.0106	0.0106
Onchocerca volvulus		0.002	0.0106	0.0587
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0043	0.0696	0.0592
Echinococcus granulosus	PDZ and LIM domain protein Zasp	0.002	0.0106	0.0106
Schistosoma mansoni	cell polarity protein	0.002	0.0106	0.0106
Loa Loa (eye worm)	9ORF binding protein 1	0.002	0.0106	0.0106
Brugia malayi	Cytochrome b5-like Heme/Steroid binding domain containing protein	0.0046	0.0787	0.0787
Brugia malayi	protein kinase C-binding protein PICK1	0.002	0.0106	0.0106
Schistosoma mansoni	dihydroceramide desaturase	0.0018	0.0073	0.0073
Schistosoma mansoni	multiple pdz domain protein	0.002	0.0106	0.0106
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.002	0.0106	0.0106
Echinococcus multilocularis	glutamate receptor interacting protein 1	0.002	0.0106	0.0106
Leishmania major	cytochrome P450 reductase, putative	0.036	0.8818	0.8805
Echinococcus multilocularis	segment polarity protein dishevelled	0.002	0.0106	0.0106
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.011	0.011
Echinococcus multilocularis	pdz domain containing protein	0.002	0.0106	0.0106
Echinococcus multilocularis	PDZ and LIM domain protein Zasp	0.002	0.0106	0.0106
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0024	0.0226	1
Echinococcus granulosus	disks large 1	0.002	0.0106	0.0106
Mycobacterium ulcerans	DNA polymerase IV	0.0043	0.0696	0.0592
Giardia lamblia	DINP protein human, muc B family	0.0022	0.0165	0.0063
Brugia malayi	Reprolysin	0.0026	0.0266	0.0266
Schistosoma mansoni	amyloid beta A4 protein related	0.002	0.0106	0.0106
Brugia malayi	PDZ domain containing protein	0.002	0.0106	0.0106
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0024	0.0226	0.0117
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0024	0.0226	0.0117
Echinococcus granulosus	L aminoadipate semialdehyde	0.0086	0.1813	0.1813
Brugia malayi	interleukin-16	0.002	0.0106	0.0106
Leishmania major	oxidoreductase-like protein	0.0046	0.0787	0.0684
Trypanosoma brucei	unspecified product	0.0036	0.0521	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1813	0.1813
Schistosoma mansoni	sap-97	0.002	0.0106	0.0106
Brugia malayi	gamma-syntrophin-like protein SYN2	0.002	0.0106	0.0106
Echinococcus granulosus	Na:H exchange regulatory cofactor NHE RF2	0.002	0.0106	0.0106
Echinococcus multilocularis	MAGUK p55 subfamily	0.002	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.002	0.0106	0.0106
Echinococcus granulosus	disks large 3	0.002	0.0106	0.0106
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.011	0.0065
Leishmania major	NADH-dependent fumarate reductase, putative	0.0046	0.0787	0.0684
Toxoplasma gondii	flavodoxin domain-containing protein	0.0201	0.4763	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 109 uM	Inhibition of endothelin converting enzyme in an RIA assay using ET-1 as substrate	ChEMBL.	8421284

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 176157

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 73448