TDR Targets

Basic information

Technical information

TDR Targets ID: 740038
Name: 3-(3-methylphenyl)-1-(1-phenylethyl)urea
MW: 254.327 | Formula: C16H18N2O
H donors: 2 H acceptors: 1 LogP: 3.19 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(NC(c1ccccc1)C)Nc1cccc(c1)C
InChi: 1S/C16H18N2O/c1-12-7-6-10-15(11-12)18-16(19)17-13(2)14-8-4-3-5-9-14/h3-11,13H,1-2H3,(H2,17,18,19)
InChiKey: AUYJIGYLBGXGDY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

IVK/0019602

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Hr1 repeat family protein	0.017	0.3071	0.3071
Echinococcus granulosus	dnaJ subfamily B	0.0466	0.904	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0051	0.0687	0.0714
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0206	0.0328
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0022	0.0106	0.0168
Echinococcus granulosus	histone lysine methyltransferase setb	0.002	0.0061	0.0067
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0348	0.6658	0.6647
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0066	0.5
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0344	0.6585	0.989
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0022	0.0106	0.0105
Entamoeba histolytica	p21-activated kinase	0.0022	0.0106	0.0074
Loa Loa (eye worm)	AGC/NDR protein kinase	0.017	0.3071	0.3071
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0019	0.0032	0.005
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0019	0.0032	0.0036
Brugia malayi	Ets-domain containing protein	0.007	0.1071	0.1071
Toxoplasma gondii	hypothetical protein	0.0055	0.0773	0.0803
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.017	0.3071	0.3397
Schistosoma mansoni	zinc finger protein	0.0019	0.0032	0.0036
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0203	0.3745	0.3725
Brugia malayi	Oxysterol binding protein	0.0019	0.0032	0.0032
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0203	0.3745	0.3745
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0745	0.0745
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0022	0.0106	0.016
Trypanosoma cruzi	hypothetical protein, conserved	0.0063	0.0916	0.1375
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0344	0.6585	0.989
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0022	0.0106	0.0158
Echinococcus granulosus	Glutaredoxin protein 5	0.0325	0.6207	0.6866
Schistosoma mansoni	dynamin	0.0019	0.0032	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Echinococcus granulosus	calcium dependent secretion activator 1	0.0019	0.0032	0.0036
Schistosoma mansoni	vav2	0.0019	0.0032	0.0036
Trypanosoma cruzi	PH domain containing protein, putative	0.0019	0.0032	0.0048
Schistosoma mansoni	oxysterol-binding protein 1	0.0019	0.0032	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0106	0.0074
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0022	0.0106	0.0158
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0063	0.0916	0.0886
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0022	0.0106	0.0105
Schistosoma mansoni	serine/threonine protein kinase	0.017	0.3071	0.3397
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0019	0.0032	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0028	0.021	0.0232
Echinococcus multilocularis	isocitrate dehydrogenase	0.0017	0.0001	0.0001
Loa Loa (eye worm)	PHD-finger family protein	0.0023	0.0129	0.0129
Echinococcus granulosus	GRB2 associated binding protein 3	0.0019	0.0032	0.0036
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0051	0.0687	0.076
Brugia malayi	PH domain containing protein	0.0019	0.0032	0.0032
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0206	0.0328
Echinococcus granulosus	protein kinase c iota type	0.017	0.3071	0.3397
Schistosoma mansoni	oxysterol-binding protein 1	0.0019	0.0032	0.0036
Trypanosoma cruzi	hypothetical protein	0.0019	0.0032	0.0048
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0063	0.0916	0.0915
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0019	0.0032	0.0032
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0019	0.0032	0.0032
Brugia malayi	Ets-domain containing protein	0.007	0.1071	0.1071
Trichomonas vaginalis	AGC family protein kinase	0.0513	1	1
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0072	0.1098	0.1215
Echinococcus granulosus	oxysterol binding protein 9	0.0019	0.0032	0.0036
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0019	0.0032	0.0048
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0.0001	0.0001
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0019	0.0032	0.0036
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0019	0.0032	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0513	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0106	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0513	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0019	0.0032	0.0032
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0066	0.0105
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0106	0.0074
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0019	0.0032	0.0036
Trypanosoma cruzi	PH domain containing protein, putative	0.0019	0.0032	0.0048
Giardia lamblia	Kinase, AGC PKA	0.0329	0.6281	1
Echinococcus granulosus	cytohesin 1	0.0019	0.0032	0.0036
Echinococcus granulosus	oxysterol binding protein 3	0.0019	0.0032	0.0036
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0745	0.0745
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0066	0.0199
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0019	0.0046	0.0051
Echinococcus multilocularis	beta 1 syntrophin	0.0019	0.0032	0.0036
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0163	0.2935	0.4456
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0203	0.3745	0.3725
Schistosoma mansoni	centaurin alpha	0.0019	0.0032	0.0036
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0066	0.0034
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.017	0.3071	0.3071
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0348	0.6658	1
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0203	0.3745	0.3725
Echinococcus multilocularis	Pleckstrin y	0.0019	0.0032	0.0036
Plasmodium vivax	hypothetical protein, conserved	0.0019	0.0032	0.005
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0106	0.0074
Echinococcus granulosus	serine/threonine protein kinase	0.0348	0.6658	0.7365
Echinococcus granulosus	transcription factor Dp 1	0.0041	0.0491	0.0543
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0069	0.1053	0.1165
Leishmania major	hypothetical protein, conserved	0.0027	0.0206	0.0312
Schistosoma mansoni	zinc finger protein	0.0019	0.0032	0.0036
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0206	0.0214
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0168	0.3035	0.3357
Loa Loa (eye worm)	AGC/PKN protein kinase	0.017	0.3071	0.3071
Schistosoma mansoni	serine/threonine-protein kinase	0.0348	0.6658	0.7365
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0066	0.0066
Echinococcus multilocularis	serine threonine protein kinase	0.017	0.3071	0.3397
Echinococcus granulosus	oxysterol binding protein 1	0.0019	0.0032	0.0036
Loa Loa (eye worm)	syntrophin-1	0.0019	0.0032	0.0032
Brugia malayi	PH domain containing protein	0.0019	0.0032	0.0032
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0019	0.0032	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0022	0.0106	0.0158
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0019	0.0032	0.0036
Schistosoma mansoni	hypothetical protein	0.004	0.0469	0.0518
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0745	0.0745
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0019	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0019	0.0032	0.005
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0019	0.0032	0.0036
Echinococcus granulosus	nervana 2	0.0325	0.6207	0.6866
Loa Loa (eye worm)	hypothetical protein	0.005	0.0671	0.0671
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0048	0.063	0.0945
Leishmania major	hypothetical protein, conserved	0.0019	0.0032	0.0048
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.0106	0.0074
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0019	0.0046	0.0051
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0019	0.0032	0.0036
Echinococcus granulosus	Pleckstrin y	0.0019	0.0032	0.0036
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0329	0.6281	0.6948
Brugia malayi	PH domain containing protein	0.0019	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Entamoeba histolytica	hypothetical protein	0.004	0.0469	0.0438
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.014	0.2484	0.7515
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.0106	0.0074
Trypanosoma cruzi	hypothetical protein	0.0019	0.0032	0.0048
Trypanosoma brucei	protein kinase, putative	0.0022	0.0106	0.0105
Trichomonas vaginalis	AGC family protein kinase	0.0513	1	1
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0019	0.0032	0.0036
Echinococcus granulosus	Oxysterol binding protein 11	0.0019	0.0032	0.0036
Echinococcus multilocularis	protein kinase c epsilon type	0.017	0.3071	0.3397
Brugia malayi	PHD-finger family protein	0.0034	0.0346	0.0346
Schistosoma mansoni	syntrophin	0.0019	0.0032	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0106	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0206	0.0206
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0019	0.0032	0.005
Echinococcus multilocularis	dynamin 1	0.0019	0.0032	0.0036
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0495	0.9623	0.9623
Echinococcus multilocularis	Pleckstrin y	0.0019	0.0032	0.0036
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0069	0.1039	0.108
Echinococcus multilocularis	Oxysterol binding protein 11	0.0019	0.0032	0.0036
Brugia malayi	Dynamin	0.0019	0.0032	0.0032
Brugia malayi	PH domain containing protein	0.0019	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0048	0.063	0.0945
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0019	0.0032	0.005
Echinococcus granulosus	beta 1 syntrophin	0.0019	0.0032	0.0036
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.017	0.3071	0.3397
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0203	0.3745	0.3725
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0203	0.3745	1
Echinococcus granulosus	dynamin 1	0.0019	0.0032	0.0036
Trypanosoma cruzi	hypothetical protein, conserved	0.0063	0.0916	0.1375
Echinococcus granulosus	Pleckstrin y	0.0019	0.0032	0.0036
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0051	0.0687	0.1094
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0019	0.0032	0.0032
Brugia malayi	Cadps2 protein	0.0019	0.0032	0.0032
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0072	0.1098	0.107
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0314	0.0314
Trichomonas vaginalis	AGC family protein kinase	0.017	0.3071	0.3049
Echinococcus multilocularis	pdz domain containing protein	0.0019	0.0032	0.0036
Brugia malayi	hypothetical protein	0.0019	0.0032	0.0032
Leishmania major	mitochondrial DNA polymerase beta	0.0344	0.6585	1
Brugia malayi	Syntrophin-1	0.0019	0.0032	0.0032
Brugia malayi	Bromodomain containing protein	0.0048	0.0615	0.0615
Entamoeba histolytica	acetyltransferase, GNAT family	0.0044	0.0552	0.0521
Toxoplasma gondii	hypothetical protein	0.0019	0.0032	0.0033
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0066	0.0034
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0019	0.0032	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0753	0.0753
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0022	0.0106	0.0105
Trypanosoma cruzi	hypothetical protein	0.0019	0.0032	0.0048
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0072	0.1098	0.1215
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0019	0.0032	0.0036
Brugia malayi	p70 ribosomal S6 kinase beta	0.0495	0.9623	0.9623
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0203	0.3745	0.3725
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0329	0.6281	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0017	0.0001	0.0001
Leishmania major	protein kinase, putative	0.0022	0.0106	0.016
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.017	0.3071	0.3397
Brugia malayi	protein kinase C II.	0.017	0.3071	0.3071
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0106	0.0074
Echinococcus granulosus	histone acetyltransferase KAT2B	0.016	0.2887	0.3194
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Echinococcus multilocularis	protein kinase c iota type	0.017	0.3071	0.3397
Schistosoma mansoni	atypical protein kinase C	0.017	0.3071	0.3397
Entamoeba histolytica	protein kinase 2, putative	0.0329	0.6281	0.6269
Trypanosoma cruzi	Protein kinase B	0.0348	0.6658	1
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0072	0.1098	0.1098
Echinococcus multilocularis	serine:threonine protein kinase 38	0.017	0.3071	0.3397
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.002	0.0061	0.0067
Schistosoma mansoni	ap endonuclease	0.002	0.0066	0.0073
Entamoeba histolytica	hypothetical protein	0.0022	0.0106	0.0074
Schistosoma mansoni	serine/threonine kinase	0.017	0.3071	0.3397
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0325	0.6207	0.6866
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0019	0.0032	0.0036
Trypanosoma cruzi	ISWI complex protein	0.0017	0.0006	0.0008
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.017	0.3071	0.3397
Loa Loa (eye worm)	oxysterol binding protein	0.0019	0.0032	0.0032
Trypanosoma brucei	PH domain containing protein, putative	0.0019	0.0032	0.0032
Brugia malayi	probable spectrin beta chain	0.0019	0.0032	0.0032
Onchocerca volvulus		0.0033	0.0314	0.0759
Brugia malayi	Dynamin	0.0019	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1278	0.1278
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0203	0.3745	0.3725
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0022	0.0106	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Schistosoma mansoni	myotubularin-related protein	0.0019	0.0032	0.0036
Brugia malayi	Bromodomain containing protein	0.0091	0.1495	0.1495
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0041	0.048	0.053
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0019	0.0032	0.0036
Schistosoma mansoni	serine/threonine protein kinase	0.017	0.3071	0.3397
Loa Loa (eye worm)	hypothetical protein	0.006	0.0866	0.0866
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0106	0.0074
Entamoeba histolytica	hypothetical protein	0.004	0.0469	0.0438
Loa Loa (eye worm)	hypothetical protein	0.002	0.0061	0.0061
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0051	0.0687	0.0657
Brugia malayi	hypothetical protein	0.004	0.0469	0.0469
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0066	0.0066
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0106	0.0074
Entamoeba histolytica	protein kinase, putative	0.0022	0.0106	0.0074
Brugia malayi	Cytohesin 3	0.0019	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Trypanosoma cruzi	hypothetical protein	0.0019	0.0032	0.0048
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0072	0.1098	0.1649
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0022	0.0106	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0163	0.2935	0.4407
Leishmania major	hypothetical protein, conserved	0.0019	0.0032	0.0048
Brugia malayi	hypothetical protein	0.0018	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.017	0.3071	0.3071
Plasmodium falciparum	histone acetyltransferase GCN5	0.0044	0.0552	0.0877
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0019	0.0046	0.0051
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0019	0.0032	0.0036
Entamoeba histolytica	protein kinase, putative	0.0022	0.0106	0.0074
Echinococcus granulosus	Rho GTPase activating protein 24	0.0019	0.0032	0.0036
Schistosoma mansoni	goodpasture antigen-binding protein	0.0019	0.0032	0.0036
Echinococcus granulosus	cpg binding protein	0.0037	0.0395	0.0437
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0022	0.0106	0.011
Echinococcus granulosus	Pleckstrin y	0.0019	0.0032	0.0036
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0051	0.0687	0.0714
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0106	0.0074
Echinococcus granulosus	fetal alzheimer antigen falz	0.0028	0.021	0.0232
Schistosoma mansoni	serine/threonine protein kinase	0.017	0.3071	0.3397
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0019	0.0032	0.0036
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0041	0.048	0.053
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0019	0.0032	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0106	0.0074
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0048	0.063	0.0945
Schistosoma mansoni	rho gtpase activating protein	0.0019	0.0032	0.0036
Trypanosoma brucei	ISWI complex protein	0.0017	0.0006	0.0006
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0001	0.0001
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0106	0.0074
Brugia malayi	Uncoordinated protein 104	0.0019	0.0032	0.0032
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0469	0.0518
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0166	0.2997	0.2975
Trichomonas vaginalis	AGC family protein kinase	0.017	0.3071	0.3049
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0106	0.0074
Echinococcus granulosus	nervana 2	0.0325	0.6207	0.6866
Leishmania major	hypothetical protein, conserved	0.0063	0.0916	0.139
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.017	0.3071	0.3397
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0019	0.0032	0.0036
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0206	0.0309
Schistosoma mansoni	hypothetical protein	0.0019	0.0032	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0106	0.0074
Schistosoma mansoni	cpg binding protein	0.0037	0.0395	0.0437
Trichomonas vaginalis	AGC family protein kinase	0.0188	0.3448	0.3427
Giardia lamblia	Histone acetyltransferase GCN5	0.0044	0.0552	0.0781
Echinococcus multilocularis	rac serine:threonine kinase	0.0348	0.6658	0.7365
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0019	0.0032	0.0036
Brugia malayi	MAX-1A	0.0019	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0745	0.0745
Echinococcus granulosus	protein kinase C gamma type	0.017	0.3071	0.3397
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0206	0.0309
Entamoeba histolytica	protein kinase, putative	0.0022	0.0106	0.0074
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0019	0.0032	0.0036
Entamoeba histolytica	protein kinase, putative	0.0022	0.0106	0.0074
Schistosoma mansoni	serine/threonine protein kinase	0.017	0.3071	0.3397
Echinococcus multilocularis	dnaJ subfamily B	0.0466	0.904	1
Trichomonas vaginalis	AGC family protein kinase	0.0513	1	1
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.017	0.3071	0.3071
Schistosoma mansoni	serine/threonine protein kinase	0.017	0.3071	0.3397
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0019	0.0046	0.0051
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0469	0.0518
Echinococcus granulosus	pdz domain containing protein	0.0019	0.0032	0.0036
Schistosoma mansoni	zinc finger protein	0.0028	0.0223	0.0247
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0536	0.0536
Trypanosoma cruzi	hypothetical protein	0.0019	0.0032	0.0048
Entamoeba histolytica	protein kinase, putative	0.017	0.3071	0.3049
Brugia malayi	Pleckstrin Homology Domain	0.0019	0.0032	0.0032
Loa Loa (eye worm)	cytohesin 3	0.0019	0.0032	0.0032
Entamoeba histolytica	hypothetical protein	0.004	0.0469	0.0438
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0066	0.01
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0106	0.0074
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0325	0.6207	0.6866
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.002	0.0061	0.0067
Brugia malayi	hypothetical protein	0.0027	0.0206	0.0206
Schistosoma mansoni	hypothetical protein	0.0037	0.04	0.0443
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0074	0.1144	0.1265
Entamoeba histolytica	hypothetical protein	0.004	0.0469	0.0438
Echinococcus multilocularis	oxysterol binding protein 9	0.0019	0.0032	0.0036
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0019	0.0032	0.0032
Toxoplasma gondii	Oxysterol-binding protein	0.0019	0.0032	0.0033
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0019	0.0032	0.0032
Brugia malayi	PH domain containing protein	0.0019	0.0032	0.0032
Echinococcus granulosus	GA binding protein alpha chain	0.007	0.1071	0.1185
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0329	0.6281	0.6948
Schistosoma mansoni	growth factor receptor-bound protein	0.0019	0.0032	0.0036
Schistosoma mansoni	serine/threonine-protein kinase	0.0348	0.6658	0.7365
Schistosoma mansoni	serine/threonine protein kinase	0.017	0.3071	0.3397
Brugia malayi	PH domain containing protein	0.0019	0.0032	0.0032
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0072	0.1098	0.1098
Echinococcus multilocularis	cpg binding protein	0.0037	0.0395	0.0437
Trypanosoma cruzi	hypothetical protein	0.0019	0.0032	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0037	0.04	0.04
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0074	0.1144	0.1265
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0001	0.0001
Echinococcus multilocularis	serine:threonine protein kinase N2	0.017	0.3071	0.3397
Entamoeba histolytica	protein kinase, putative	0.0513	1	1
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0022	0.0106	0.0074
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0051	0.0687	0.0657
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0019	0.0032	0.0048
Schistosoma mansoni	ets-related	0.0213	0.3955	0.4375
Loa Loa (eye worm)	bromodomain containing protein	0.0024	0.0142	0.0142
Plasmodium falciparum	PH domain-containing protein, putative	0.0019	0.0032	0.005
Loa Loa (eye worm)	fli-1 protein	0.0213	0.3955	0.3955
Schistosoma mansoni	goodpasture antigen-binding protein	0.0019	0.0032	0.0036
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0348	0.6658	0.6647
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0022	0.0106	0.0158
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0072	0.1098	0.1667
Schistosoma mansoni	hypothetical protein	0.0017	0.0006	0.0007
Echinococcus granulosus	NDR protein kinase	0.017	0.3071	0.3397
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0022	0.0106	0.0158
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0168	0.3035	0.3357
Toxoplasma gondii	exonuclease III APE	0.002	0.0066	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0028	0.021	0.0232
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0106	0.0074
Trypanosoma cruzi	NIMA-related kinase, putative	0.0022	0.0106	0.0158
Brugia malayi	Variant SH3 domain containing protein	0.0019	0.0032	0.0032
Schistosoma mansoni	gabp alpha	0.007	0.1071	0.1185
Brugia malayi	Isocitrate dehydrogenase	0.0017	0.0001	0.0001
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0063	0.0916	0.0886
Plasmodium vivax	PH domain containing protein	0.0019	0.0032	0.005
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0022	0.0106	0.0074
Schistosoma mansoni	hypothetical protein	0.0023	0.0129	0.0142
Brugia malayi	isocitrate dehydrogenase	0.0017	0.0001	0.0001
Loa Loa (eye worm)	rho-GTPase-activating	0.0019	0.0032	0.0032
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0072	0.1098	0.1649
Schistosoma mansoni	hypothetical protein	0.0019	0.0032	0.0036
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0066	0.0034
Schistosoma mansoni	serine/threonine protein kinase	0.017	0.3071	0.3397
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0314	0.0314
Loa Loa (eye worm)	Plekhf2 protein	0.0019	0.0032	0.0032
Entamoeba histolytica	hypothetical protein	0.0022	0.0106	0.0074
Schistosoma mansoni	cpg binding protein	0.0033	0.0314	0.0347
Leishmania major	protein kinase, putative	0.0022	0.0106	0.016
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0022	0.0106	0.0168
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0022	0.0106	0.016
Echinococcus granulosus	DCC interacting protein 13 beta	0.0019	0.0032	0.0036
Echinococcus granulosus	serine:threonine protein kinase N2	0.017	0.3071	0.3397
Echinococcus multilocularis	cytohesin 1	0.0019	0.0032	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0106	0.0074
Echinococcus multilocularis	Glutaredoxin protein 5	0.0325	0.6207	0.6866
Trichomonas vaginalis	AGC family protein kinase	0.0513	1	1
Loa Loa (eye worm)	PH domain-containing protein	0.0019	0.0032	0.0032
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.007	0.1071	0.1071
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0344	0.6585	0.6585
Schistosoma mansoni	ap endonuclease	0.002	0.0066	0.0073
Echinococcus granulosus	myotubularin protein 13	0.0019	0.0032	0.0036
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.017	0.3071	0.3071
Leishmania major	hypothetical protein, conserved	0.0017	0.0006	0.0008
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0019	0.0032	0.005
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Echinococcus granulosus	zinc finger protein	0.0028	0.0223	0.0247
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.0106	0.0074
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0019	0.0032	0.0036
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0066	0.0099
Brugia malayi	Protein kinase domain containing protein	0.017	0.3071	0.3071
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0106	0.0074
Trypanosoma cruzi	PH domain containing protein, putative	0.0019	0.0032	0.0048
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0019	0.0032	0.005
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0329	0.6281	1
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0066	0.0066
Brugia malayi	Fli-1 protein	0.0213	0.3955	0.3955
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0022	0.0106	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Brugia malayi	Oxysterol-binding protein	0.0019	0.0032	0.0032
Entamoeba histolytica	protein kinase, putative	0.0022	0.0106	0.0074
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0513	1	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0206	0.0328
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0329	0.6281	0.9433
Echinococcus multilocularis	oxysterol binding protein 3	0.0019	0.0032	0.0036
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0066	0.0105
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0019	0.0032	0.0036
Toxoplasma gondii	hypothetical protein	0.0019	0.0032	0.0033
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0203	0.3745	0.3745
Leishmania major	folate/biopterin transporter, putative	0.0022	0.0106	0.016
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.002	0.0061	0.0067
Brugia malayi	acetyltransferase, GNAT family protein	0.0168	0.3035	0.3035
Echinococcus granulosus	Protein kinase C brain isozyme	0.017	0.3071	0.3397
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0059	0.0843	0.1265
Echinococcus granulosus	protein kinase c epsilon type	0.017	0.3071	0.3397
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0072	0.1098	0.1098
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0001	0.0001
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0181	0.3305	1
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0017	0.0001	0.0001
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0106	0.0074
Echinococcus multilocularis	nervana 2	0.0325	0.6207	0.6866
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0019	0.0032	0.0036
Loa Loa (eye worm)	uncoordinated protein 104	0.0019	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Entamoeba histolytica	protein kinase, putative	0.0513	1	1
Plasmodium falciparum	oxysterol-binding protein, putative	0.0019	0.0032	0.005
Echinococcus granulosus	serine threonine protein kinase nrc	0.0329	0.6281	0.6948
Toxoplasma gondii	AtPH1 family protein	0.0019	0.0032	0.0033
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0019	0.0032	0.0033
Schistosoma mansoni	hypothetical protein	0.0019	0.0032	0.0036
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.017	0.3071	0.3397
Brugia malayi	TBC domain containing protein	0.0019	0.0032	0.0032
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0206	0.0206
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0019	0.0032	0.0036
Schistosoma mansoni	hypothetical protein	0.0019	0.0032	0.0036
Brugia malayi	PH domain containing protein	0.0019	0.0032	0.0032
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0019	0.0032	0.0036
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0019	0.0032	0.0048
Mycobacterium ulcerans	hypothetical protein	0.0181	0.3305	0.8805
Schistosoma mansoni	hypothetical protein	0.0019	0.0032	0.0036
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0022	0.0106	0.0158
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0066	0.0073
Leishmania major	serine/threonine-protein kinase a, putative	0.0022	0.0106	0.016
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.017	0.3071	0.3397
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.04	0.04
Echinococcus granulosus	pleckstrin y domain containing family A	0.0019	0.0032	0.0036
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0017	0.0001	0.0001
Echinococcus multilocularis	zinc finger protein	0.0028	0.0223	0.0247
Brugia malayi	Protein kinase domain containing protein	0.017	0.3071	0.3071
Trichomonas vaginalis	AGC family protein kinase	0.0513	1	1
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0203	0.3745	0.3725
Brugia malayi	PH domain containing protein	0.0019	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0513	1	1
Echinococcus multilocularis	actin binding protein anillin	0.0019	0.0032	0.0036
Brugia malayi	PH domain containing protein	0.0019	0.0032	0.0032
Trichomonas vaginalis	AGC family protein kinase	0.017	0.3071	0.3049
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0106	0.0074
Trypanosoma cruzi	PH domain containing protein, putative	0.0019	0.0032	0.0048
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0066	0.0073
Trypanosoma cruzi	hypothetical protein	0.0019	0.0032	0.0048
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0022	0.0106	0.0074
Entamoeba histolytica	protein kinase, putative	0.0495	0.9623	0.9622
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0469	0.0518
Trichomonas vaginalis	AGC family protein kinase	0.0022	0.0106	0.0074
Echinococcus multilocularis	Pleckstrin y	0.0019	0.0032	0.0036
Echinococcus multilocularis	transcription factor Dp 1	0.0041	0.0491	0.0543
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0066	0.0099
Schistosoma mansoni	hypothetical protein	0.0466	0.904	1
Loa Loa (eye worm)	acetyltransferase	0.0168	0.3035	0.3035
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0163	0.2935	0.2934
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0203	0.3745	0.3725
Schistosoma mansoni	zinc finger protein	0.0017	0.0006	0.0007
Onchocerca volvulus		0.0203	0.3745	1
Schistosoma mansoni	cpg binding protein	0.0037	0.0395	0.0437
Brugia malayi	Plekhf2 protein	0.0019	0.0032	0.0032
Toxoplasma gondii	protein kinase domain-containing protein	0.0022	0.0106	0.011
Echinococcus multilocularis	GA binding protein alpha chain	0.007	0.1071	0.1185
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0032	0.0032
Schistosoma mansoni	dynamin	0.0019	0.0032	0.0036
Toxoplasma gondii	AGC kinase	0.0495	0.9623	1
Trypanosoma cruzi	ISWI complex protein	0.0017	0.0006	0.0008
Echinococcus multilocularis	nervana 2	0.0325	0.6207	0.6866
Trypanosoma cruzi	NIMA-related kinase, putative	0.0022	0.0106	0.0158
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.017	0.3071	0.3071
Schistosoma mansoni	bromodomain containing protein	0.0078	0.1226	0.1356
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0072	0.1098	0.1215
Echinococcus multilocularis	serine:threonine protein kinase N2	0.017	0.3071	0.3397
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0019	0.0032	0.0036
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0203	0.3745	0.5919
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0066	0.5
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0048	0.063	0.0629
Echinococcus multilocularis	oxysterol binding protein 1	0.0019	0.0032	0.0036
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0019	0.0032	0.0032
Echinococcus multilocularis	myotubularin protein 13	0.0019	0.0032	0.0036

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 740038