TDR Targets

Basic information

Technical information

TDR Targets ID: 794751
Name: 1-(2-methoxyphenyl)-4-(4-methylphenyl)sulfony lpiperazine
MW: 346.444 | Formula: C18H22N2O3S
H donors: 0 H acceptors: 2 LogP: 3 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1N1CCN(CC1)S(=O)(=O)c1ccc(cc1)C
InChi: 1S/C18H22N2O3S/c1-15-7-9-16(10-8-15)24(21,22)20-13-11-19(12-14-20)17-5-3-4-6-18(17)23-2/h3-10H,11-14H2,1-2H3
InChiKey: LGBHNNGNTSGBAA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(2-methoxyphenyl)-4-(4-methylphenyl)sulfonyl-piperazine
83863-44-9
AG-205/36815005
1-(2-Methoxyphenyl)-4-(p-tolylsulphonyl)piperazine
EINECS 281-107-1
1-(2-Methoxy-phenyl)-4-(toluene-4-sulfonyl)-piperazine
BAS 00451426
Oprea1_277459
ZINC00029412
Oprea1_847731
A1271/0058149

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0438	0.0981
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0241	0.0374
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0739	0.8795
Brugia malayi	Sugar transporter family protein	0.0015	0.0241	0.0352
Trichomonas vaginalis	set domain proteins, putative	0.0273	0.6111	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	0.2285	0.3935
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0635	0.1042
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.024	0.5358	0.9323
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0438	0.0438
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.062	0.1016
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Leishmania major	protein kinase, putative	0.0032	0.0635	0.7519
Loa Loa (eye worm)	hypothetical protein	0.0133	0.2931	0.5068
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.0241	0.2665
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0022	0.0396	0.0623
Leishmania major	glucose transporter, lmgt2	0.0032	0.0644	0.7634
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0156	0.0203
Toxoplasma gondii	glycyl-tRNA synthetase	0.0006	0.0041	0.0062
Leishmania major	glucose transporter, lmgt3	0.0032	0.0644	0.7634
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.062	0.6516
Brugia malayi	hypothetical protein	0.0015	0.0241	0.0352
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0174	0.0234
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0241	0.0352
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0147	0.0222
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0644	0.7634
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0012	0.0174	0.1839
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0012	0.0174	0.4486
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0012	0.0174	0.1839
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0022	0.0396	0.0598
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0167	0.3703	0.9046
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0012	0.0174	0.1839
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0739	0.8795
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0012	0.0174	0.1839
Loa Loa (eye worm)	cytochrome P450	0.0012	0.0174	0.0234
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0438	0.5086
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0644	0.7634
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0022	0.0396	0.0623
Plasmodium falciparum	hexose transporter	0.0105	0.2285	0.2285
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0012	0.0174	0.1839
Plasmodium falciparum	protein kinase 7	0.0295	0.6626	0.6626
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.0689	0.1136
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0012	0.0174	0.1839
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0012	0.0174	0.1839
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0644	0.7634
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0015	0.0241	0.6499
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0012	0.0174	0.4486
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0169	0.375	0.5659
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Plasmodium falciparum	proline--tRNA ligase	0.0037	0.0739	0.0739
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0241	1
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0012	0.0174	0.4486
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0241	0.0364
Mycobacterium leprae	putative cytochrome p450	0.0012	0.0174	0.2506
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0037	0.0739	0.1115
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0438	0.0696
Trypanosoma cruzi	hexose transporter	0.0032	0.0644	0.7634
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Schistosoma mansoni	glucose transport protein	0.0105	0.2285	0.5543
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0689	0.1136
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.1098	0.1853
Loa Loa (eye worm)	RecQ helicase	0.0022	0.0396	0.0623
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0012	0.0174	0.1839
Onchocerca volvulus		0.0273	0.6111	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.062	0.1432
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.059	0.0963
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0396	0.0623
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0012	0.0174	0.1839
Trichomonas vaginalis	conserved hypothetical protein	0.0005	0.0025	0.0019
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Brugia malayi	Sugar transporter family protein	0.0105	0.2285	0.3935
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0241	0.0495
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0012	0.0174	0.1839
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0636	0.0636
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0012	0.0174	0.1839
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0241	0.0352
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0012	0.0174	0.4486
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0006	0.0041	0.0192
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0635	0.1042
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0635	0.1042
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0241	0.0364
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0635	0.1042
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	0.2285	0.3935
Schistosoma mansoni	glucose transport protein	0.0105	0.2285	0.5543
Entamoeba histolytica	acetyltransferase, GNAT family	0.0045	0.093	1
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0012	0.0174	0.1839
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0012	0.0174	0.1839
Brugia malayi	Pre-SET motif family protein	0.024	0.5358	0.9323
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0241	0.0352
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0012	0.0174	0.4486
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Brugia malayi	Bloom's syndrome protein homolog	0.0022	0.0396	0.0623
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0012	0.0174	0.1839
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0644	0.1035
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0636	0.0636
Echinococcus granulosus	solute carrier family 22	0.0015	0.0241	0.0352
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0241	0.0374
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0006	0.0041	0.0262
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Schistosoma mansoni	hypothetical protein	0.0184	0.409	1
Entamoeba histolytica	recQ family DNA helicase	0.0011	0.0156	0.168
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0022	0.0396	0.0623
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.2285	0.3935
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.031	0.3512
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0438	0.5086
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0444	1	1
Entamoeba histolytica	recQ family helicase, putative	0.0022	0.0396	0.4259
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0012	0.0174	0.1839
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0049	0.1023	0.1545
Onchocerca volvulus	Huntingtin homolog	0.0133	0.2931	0.4582
Loa Loa (eye worm)	hypothetical protein	0.0031	0.062	0.1016
Schistosoma mansoni	sugar transporter	0.0015	0.0241	0.0495
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0739	0.8795
Leishmania major	hypothetical protein, conserved	0.0015	0.0241	0.2665
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0635	0.1042
Plasmodium vivax	sugar transporter, putative	0.0015	0.0241	0.0241
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0689	0.1601
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0012	0.0174	0.1839
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0049	0.1023	0.1545
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0156	0.0236
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0012	0.0174	0.0263
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0438	0.6932
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0169	0.375	0.375
Giardia lamblia	Sugar-proton symporter	0.0015	0.0241	0.2255
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0241	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0241	0.0352
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0011	0.0156	0.0156
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0012	0.0174	0.4486
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0358	1
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0012	0.0174	0.4486
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0012	0.0174	0.4486
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0241	0.0374
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.062	0.1016
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.062	0.0995
Giardia lamblia	Sgs1 DNA helicase, putative	0.0022	0.0396	0.3995
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0012	0.0174	0.4486
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0241	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0257	0.5744	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0644	0.7634
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.059	0.0963
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0438	0.0661
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0689	0.1601
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0133	0.2931	0.5068
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0358	0.5587
Schistosoma mansoni	glucose transporter	0.0015	0.0241	0.0495
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0012	0.0174	0.4486
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.066	0.1086
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0022	0.0396	0.4573
Leishmania major	threonyl-tRNA synthetase, putative	0.0006	0.0041	0.0192
Onchocerca volvulus	Huntingtin homolog	0.0133	0.2931	0.4582
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0006	0.0041	0.0192
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0644	0.7634
Schistosoma mansoni	protein kinase	0.0032	0.0635	0.1468
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0372	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0635	0.1042
Plasmodium vivax	SET domain protein, putative	0.0034	0.0689	0.0689
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0034	0.0689	0.1601
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0438	0.0696
Brugia malayi	hypothetical protein	0.0015	0.0241	0.0352
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0011	0.0156	0.1617
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0012	0.0174	0.1839
Brugia malayi	Sugar transporter family protein	0.0015	0.0241	0.0352
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.0689	0.1136
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0636	0.0636
Plasmodium vivax	glycine--tRNA ligase, putative	0.0006	0.0041	0.0041
Entamoeba histolytica	protein kinase, putative	0.0032	0.0635	0.6827
Trypanosoma brucei	cytochrome P450, putative	0.0041	0.0836	1
Entamoeba histolytica	glycyl-tRNA synthetase, putative	0.0006	0.0041	0.0438
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0022	0.0396	0.0396
Entamoeba histolytica	hypothetical protein	0.0023	0.0438	0.4705
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0487	0.0782
Echinococcus multilocularis	General substrate transporter	0.009	0.1951	0.3349
Brugia malayi	major facilitator superfamily protein	0.0015	0.0241	0.0352
Schistosoma mansoni	hypothetical protein	0.0052	0.1098	0.261
Brugia malayi	cytochrome P450	0.0012	0.0174	0.0234
Plasmodium falciparum	histone acetyltransferase GCN5	0.0045	0.093	0.093
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0438	0.0696
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0644	0.7634
Trichomonas vaginalis	DNA helicase recq, putative	0.0022	0.0396	0.0628
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0241	0.0352
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0644	0.1035
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0022	0.0396	0.0396
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0241	0.0352
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0012	0.0174	0.1839
Chlamydia trachomatis	proline--tRNA ligase	0.0011	0.0159	0.2978
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0644	0.7634
Leishmania major	cytochrome p450-like protein	0.0012	0.0174	0.1839
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0012	0.0174	0.1839
Toxoplasma gondii	protein kinase, putative	0.0295	0.6626	1
Echinococcus granulosus	survival motor neuron protein 1	0.0257	0.5744	1
Echinococcus granulosus	General substrate transporter	0.009	0.1951	0.3349
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0005	0.0029	0.0043
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0049	0.1023	0.1023
Echinococcus granulosus	solute carrier family 22	0.0015	0.0241	0.0352
Loa Loa (eye worm)	sugar transporter	0.0105	0.2285	0.3935
Echinococcus multilocularis	bloom syndrome protein	0.0022	0.0396	0.0623
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.02	0.0279
Trichomonas vaginalis	DNA helicase recq1, putative	0.0022	0.0396	0.0628
Schistosoma mansoni	glucose transport protein	0.0105	0.2285	0.5543
Trypanosoma cruzi	cytochrome P450, putative	0.0041	0.0836	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Loa Loa (eye worm)	acetyltransferase	0.0167	0.3703	0.6422
Brugia malayi	hypothetical protein	0.0257	0.5744	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0022	0.0396	0.0623
Plasmodium vivax	hexose transporter	0.0105	0.2285	0.2285
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0241	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0241	0.0352
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0012	0.0174	0.1839
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0012	0.0174	0.1839
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0644	0.7634
Leishmania major	cytochrome p450-like protein	0.0012	0.0174	0.1839
Toxoplasma gondii	facilitative glucose transporter GT1	0.0105	0.2285	0.3449
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0241	0.0352
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0015	0.0241	0.2665
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0241	0.0352
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0438	0.5086
Trypanosoma cruzi	cytochrome P450, putative	0.0041	0.0836	1
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0012	0.0174	0.4486
Schistosoma mansoni	hypothetical protein	0.0184	0.409	1
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0644	0.1035
Entamoeba histolytica	recQ family helicase, putative	0.0011	0.0147	0.1578
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0241	0.0352
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0012	0.0174	0.1839
Trypanosoma brucei	sugar transporter, putative	0.0015	0.0241	0.2665
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0159	1
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.062	0.6669
Schistosoma mansoni	hypothetical protein	0.0012	0.0174	0.033
Loa Loa (eye worm)	cytochrome P450 family protein	0.0041	0.0836	0.1395
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0635	0.102
Trichomonas vaginalis	conserved hypothetical protein	0.0005	0.0025	0.0019
Plasmodium vivax	ATP-dependent DNA helicase Q1, putative	0.0011	0.0147	0.0147
Entamoeba histolytica	protein kinase, putative	0.0032	0.0635	0.6827
Echinococcus granulosus	bloom syndrome protein	0.0022	0.0396	0.0623
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0241	0.0352
Brugia malayi	Cytochrome P450 family protein	0.0041	0.0836	0.1395
Echinococcus granulosus	geminin	0.0184	0.409	0.7099
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0006	0.0041	0.0062
Schistosoma mansoni	protein kinase	0.0032	0.0635	0.1468
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.062	0.1432
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0241	0.0374
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0635	0.1042
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0739	0.8795
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0241	0.0352
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0635	0.1042
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0022	0.0396	0.0623
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0011	0.0156	0.1617
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0006	0.0041	0.0192
Loa Loa (eye worm)	cytochrome P450 family protein	0.0041	0.0836	0.1395
Plasmodium vivax	proline--tRNA ligase, putative	0.0037	0.0739	0.0739
Echinococcus multilocularis	geminin	0.0184	0.409	0.7099
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0241	0.0352
Echinococcus multilocularis	survival motor neuron protein 1	0.0257	0.5744	1
Schistosoma mansoni	hypothetical protein	0.0105	0.2285	0.5543
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0012	0.0174	0.4486
Schistosoma mansoni	protein kinase	0.0032	0.0635	0.1468
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0012	0.0174	0.4486
Schistosoma mansoni	sugar transporter	0.0015	0.0241	0.0495
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0006	0.0041	0.0192
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0438	0.5086
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0241	0.0352
Mycobacterium leprae	Conserved hypothetical protein	0.0012	0.0174	0.2506
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0012	0.0174	0.4486
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0174	0.0234
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0438	1
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0006	0.0041	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0241	0.0352
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0644	0.1035
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0644	0.1035
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0241	0.0374
Onchocerca volvulus		0.0052	0.1098	0.1459
Loa Loa (eye worm)	hypothetical protein	0.0031	0.062	0.1016
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0636	0.0959
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Brugia malayi	acetyltransferase, GNAT family protein	0.0167	0.3703	0.6422
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0241	0.0374
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0167	0.3703	0.6422
Brugia malayi	hypothetical protein	0.0015	0.0241	0.0352
Schistosoma mansoni	sugar transporter	0.0015	0.0241	0.0495
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0689	0.1601
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0174	0.0234
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0006	0.0041	0.0045
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.0689	0.1136
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0012	0.0174	0.4486
Leishmania major	cytochrome p450-like protein	0.0041	0.0836	1
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0015	0.0241	0.0241
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0162	0.3597	0.6235
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0012	0.0174	0.4486
Treponema pallidum	ATP-dependent DNA helicase	0.0011	0.0156	0.9776
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0012	0.0174	0.4486
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0644	0.7634
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0241	0.0352
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0438	0.0696
Schistosoma mansoni	sugar transporter	0.0015	0.0241	0.0495
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0012	0.0174	0.1839
Schistosoma mansoni	DNA helicase recq5	0.0022	0.0396	0.0878
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.2285	0.3935
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0636	0.0636
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0635	0.1042
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0739	0.8795
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0041	0.0836	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.2285	0.3935
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0644	0.7634
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0636	0.0636
Schistosoma mansoni	cytochrome P450	0.0012	0.0174	0.033
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0635	0.7519
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0241	0.0352
Trichomonas vaginalis	conserved hypothetical protein	0.0105	0.2285	0.3725
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0241	0.0352
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0241	0.0352
Echinococcus granulosus	solute carrier family 22	0.0015	0.0241	0.0352
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0644	0.7634
Trypanosoma cruzi	glucose transporter, putative	0.0015	0.0241	0.2665
Echinococcus multilocularis		0.0012	0.0174	0.0234
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0644	0.7634
Giardia lamblia	Histone acetyltransferase GCN5	0.0045	0.093	1
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0022	0.0396	0.0623
Brugia malayi	Cytochrome P450 family protein	0.0041	0.0836	0.1395
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0636	0.0636
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0015	0.0241	0.6499
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0012	0.0174	0.1839
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0241	0.0352
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	0.2285	0.3935
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0636	0.0959
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0022	0.0396	0.4573
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0022	0.0396	0.4573
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0438	0.0438
Schistosoma mansoni	survival motor neuron protein	0.0052	0.1098	0.261
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0635	0.1468
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0241	0.0364
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0049	0.1023	0.1656
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0105	0.2285	0.3935
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0012	0.0174	0.4486
Brugia malayi	hypothetical protein	0.0133	0.2931	0.5068
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0012	0.0174	0.4486
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.062	0.1016
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.062	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0644	0.7634
Brugia malayi	Cam kinase protein 1	0.0032	0.0635	0.1042
Brugia malayi	Pre-SET motif family protein	0.0034	0.0689	0.1136
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0241	0.0352
Schistosoma mansoni	DNA helicase recq1	0.0022	0.0396	0.0878
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0241	0.0352
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0049	0.1023	0.1723
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0241	0.2665
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Leishmania major	glucose transporter, lmgt1	0.0032	0.0644	0.7634
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0438	0.0696
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0241	0.2665
Brugia malayi	major facilitator superfamily protein	0.0015	0.0241	0.0352
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0006	0.0041	0.0192
Trypanosoma cruzi	sugar transporter, putative	0.0015	0.0241	0.2665
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0022	0.0396	0.0598
Echinococcus granulosus	solute carrier family 22	0.0015	0.0241	0.0352
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0049	0.1023	0.1656
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0438	0.0981
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Mycobacterium ulcerans	sugar transporter	0.0015	0.0241	0.2665
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0644	0.1035
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0635	0.1042
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Plasmodium vivax	threonine--tRNA ligase, putative	0.0006	0.0041	0.0041
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0241	0.0364
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0012	0.0174	0.4486
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0644	0.7634
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0644	0.7634
Trichomonas vaginalis	conserved hypothetical protein	0.0005	0.0025	0.0019
Schistosoma mansoni	blooms syndrome DNA helicase	0.0011	0.0147	0.0262
Toxoplasma gondii	YbaK/proline-tRNA ligase associated domain-containing protein	0.0005	0.0025	0.0038
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Leishmania major	myo-inositol/proton symporter (MIT)	0.0015	0.0241	0.2665
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0636	0.0636
Echinococcus granulosus	cytochrome P450 2K1	0.0012	0.0174	0.0234
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0438	0.4463
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0636	0.0959
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0156	0.0203
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0011	0.0159	0.1649
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0636	0.0636
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0636	0.0636
Schistosoma mansoni	blooms syndrome DNA helicase	0.0011	0.0156	0.0285
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0241	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0241	0.0352
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.062	0.1016
Onchocerca volvulus		0.0034	0.0689	0.0762
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0034	0.0689	0.104
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0169	0.375	0.375
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0438	0.5086
Plasmodium falciparum	threonine--tRNA ligase	0.0006	0.0041	0.0041
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0644	0.7634
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0644	0.7634
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0241	0.0374
Trichomonas vaginalis	DNA helicase recq, putative	0.0022	0.0396	0.0628
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0241	0.0352
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0635	0.1042
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0006	0.0041	0.0192
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0644	0.1035
Plasmodium vivax	SET domain containing protein	0.0005	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0241	0.0352
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0358	1
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0022	0.0396	0.0623
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0012	0.0174	0.1839
Loa Loa (eye worm)	sugar transporter	0.0015	0.0241	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0569	0.0926
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.2285	0.3935
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0241	0.2665
Entamoeba histolytica	threonyl-tRNA synthetase, putative	0.0006	0.0041	0.0438
Loa Loa (eye worm)	CYP4Cod1	0.0041	0.0836	0.1395
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0241	0.0374
Giardia lamblia	Hexose transporter	0.0015	0.0241	0.2255
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0635	0.1042

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 794751